@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id4ec3ed81/Point/cc13397e8040cba488d9ef2e97c0373d>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id4ec3ed81> ;
        gpml:graphRef     "cdf04" ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "-1.0"^^xsd:double ;
        gpml:x            "134.79554539226234"^^xsd:double ;
        gpml:y            "155.21573858557792"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ide473476>
        rdf:type            gpml:Interaction ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:color          "0" ;
        gpml:connectorType  "Straight" ;
        gpml:graphId        "ide473476" ;
        gpml:hasPoint       <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ide473476/Point/6833ea167c272e9411685b9f1affdf78> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ide473476/Point/17ece6d7131461bf9a8c714950f48eed> ;
        gpml:lineStyle      "Solid" ;
        gpml:lineThickness  "1.0"^^xsd:double ;
        gpml:zorder         "12288"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ided3a768c>
        rdf:type                 gpml:Interaction ;
        dcterms:isPartOf         <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:biopaxRef           "db5" ;
        gpml:color               "0" ;
        gpml:connectorType       "Elbow" ;
        gpml:graphId             "ided3a768c" ;
        gpml:hasComment          <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/f7416e1849532d88335a75959acfd0b4> ;
        gpml:hasPoint            <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ided3a768c/Point/35832b00dbcac11cf6435c6bf20d79d5> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ided3a768c/Point/bfe91c862409a7b72b81fa17c23450cb> ;
        gpml:hasPublicationXref  <https://identifiers.org/pubmed/16778732> ;
        gpml:lineStyle           "Solid" ;
        gpml:lineThickness       "1.0"^^xsd:double ;
        gpml:zorder              "12288"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id1add93cf/Point/60ea1e359d6c8de45c571e10ec3d0b8>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id1add93cf> ;
        gpml:graphRef     "fb7ba" ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "0.0"^^xsd:double ;
        gpml:x            "350.4334054745662"^^xsd:double ;
        gpml:y            "228.89475093125708"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/InfoBox/dbfae1c01633896a29f8d4e379eab83>
        rdf:type          gpml:InfoBox ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:centerX      "0.0"^^xsd:double ;
        gpml:centerY      "0.0"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/cdf04>
        rdf:type             gpml:DataNode ;
        dcterms:isPartOf     <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:align           "Center" ;
        gpml:centerX         "134.79554539226234"^^xsd:double ;
        gpml:centerY         "165.21573858557792"^^xsd:double ;
        gpml:color           "ff" ;
        gpml:fillColor       "ffffff" ;
        gpml:fontDecoration  "Normal" ;
        gpml:fontName        "Arial" ;
        gpml:fontSize        "10.0"^^xsd:double ;
        gpml:fontStrikethru  "Normal" ;
        gpml:fontStyle       "Normal" ;
        gpml:fontWeight      "Normal" ;
        gpml:graphId         "cdf04" ;
        gpml:height          "20.0"^^xsd:double ;
        gpml:lineStyle       "Solid" ;
        gpml:lineThickness   "1.0"^^xsd:double ;
        gpml:shapeType       "Rectangle" ;
        gpml:textlabel       "heroin" ;
        gpml:type            "Metabolite" ;
        gpml:valign          "Middle" ;
        gpml:width           "80.0"^^xsd:double ;
        gpml:xrefDataSource  "ChEBI" ;
        gpml:xrefId          "CHEBI:27808" ;
        gpml:zorder          "32768"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id294e530e/Point/9f13d9849e5632d18ae8ae877f04519f>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id294e530e> ;
        gpml:graphRef     "c446d" ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "-1.0"^^xsd:double ;
        gpml:x            "236.62682111242663"^^xsd:double ;
        gpml:y            "218.31038879133942"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/idee25ceb0/Point/593f1b15fd4b1d1801979be75fef2a46>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/idee25ceb0> ;
        gpml:graphRef     "cfe59" ;
        gpml:relX         "-1.0"^^xsd:double ;
        gpml:relY         "0.0"^^xsd:double ;
        gpml:x            "296.9334054745662"^^xsd:double ;
        gpml:y            "165.21573858557792"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id8f564c1a>
        rdf:type            gpml:Interaction ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:color          "0" ;
        gpml:connectorType  "Straight" ;
        gpml:graphId        "id8f564c1a" ;
        gpml:hasPoint       <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id8f564c1a/Point/e050aeb4a24feb91129b2694366e6aee> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id8f564c1a/Point/8790f516c7a6e62ac582bf70899eec8a> ;
        gpml:lineStyle      "Solid" ;
        gpml:lineThickness  "1.0"^^xsd:double ;
        gpml:zorder         "12288"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/1ed071423f270ddf8bce181155ab14d3>
        rdf:type          gpml:Comment ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/fe3b3> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/ec2c5> ;
        gpml:commentText  "catalyzed in liver; catalytic efficiency is substantially greater for hCE-2 compared to other esterases." .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/b4932>
        rdf:type                 gpml:DataNode ;
        dcterms:isPartOf         <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:align               "Center" ;
        gpml:biopaxRef           "db5" ;
        gpml:centerX             "236.62682111242663"^^xsd:double ;
        gpml:centerY             "54.0"^^xsd:double ;
        gpml:color               "0" ;
        gpml:fillColor           "ffffff" ;
        gpml:fontDecoration      "Normal" ;
        gpml:fontName            "Arial" ;
        gpml:fontSize            "12.0"^^xsd:double ;
        gpml:fontStrikethru      "Normal" ;
        gpml:fontStyle           "Normal" ;
        gpml:fontWeight          "Normal" ;
        gpml:graphId             "b4932" ;
        gpml:hasComment          <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/e31e2bbf4d0756299ff4cb1f89a23d0f> ;
        gpml:hasPublicationXref  <https://identifiers.org/pubmed/16778732> ;
        gpml:height              "25.0"^^xsd:double ;
        gpml:lineStyle           "Solid" ;
        gpml:lineThickness       "1.0"^^xsd:double ;
        gpml:shapeType           "Rectangle" ;
        gpml:textlabel           "Pseudo-ChE" ;
        gpml:type                "Protein" ;
        gpml:valign              "Middle" ;
        gpml:width               "90.0"^^xsd:double ;
        gpml:xrefDataSource      "Ensembl" ;
        gpml:xrefId              "ENSG00000114200" ;
        gpml:zorder              "32768"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id4ec3ed81/Point/cd403f6e9fee232caa1965dfccc0a43e>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id4ec3ed81> ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "0.0"^^xsd:double ;
        gpml:x            "242.61447543341427"^^xsd:double ;
        gpml:y            "90.0"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id294e530e/Point/fd4c456982cb05d64d60d00e31e822e0>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id294e530e> ;
        gpml:graphRef     "fd293" ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "0.0"^^xsd:double ;
        gpml:x            "236.5089703143742"^^xsd:double ;
        gpml:y            "165.21573858557792"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id8f564c1a/Point/8790f516c7a6e62ac582bf70899eec8a>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id8f564c1a> ;
        gpml:graphRef     "be981" ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "1.0"^^xsd:double ;
        gpml:x            "350.4334054745662"^^xsd:double ;
        gpml:y            "289.21573858557804"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/247d6f5458c3d7a9bbfbf43b20871a95>
        rdf:type          gpml:Comment ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/cfe59> ;
        gpml:commentText  "6-monoacetylmorphine" .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/e31e2bbf4d0756299ff4cb1f89a23d0f>
        rdf:type          gpml:Comment ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/b4932> ;
        gpml:commentText  "pseudocholinesterase; catalysation takes place in serum" .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/c446d>
        rdf:type                 gpml:DataNode ;
        dcterms:isPartOf         <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:align               "Center" ;
        gpml:biopaxRef           "c81" ;
        gpml:centerX             "236.62682111242663"^^xsd:double ;
        gpml:centerY             "228.31038879133942"^^xsd:double ;
        gpml:color               "0" ;
        gpml:fillColor           "ffffff" ;
        gpml:fontDecoration      "Normal" ;
        gpml:fontName            "Arial" ;
        gpml:fontSize            "10.0"^^xsd:double ;
        gpml:fontStrikethru      "Normal" ;
        gpml:fontStyle           "Normal" ;
        gpml:fontWeight          "Normal" ;
        gpml:graphId             "c446d" ;
        gpml:hasComment          <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/7aaa8589fb7dd8b4490f96fa8bde3509> ;
        gpml:hasPublicationXref  <https://identifiers.org/pubmed/12773168> ;
        gpml:height              "20.0"^^xsd:double ;
        gpml:lineStyle           "Solid" ;
        gpml:lineThickness       "1.0"^^xsd:double ;
        gpml:shapeType           "Rectangle" ;
        gpml:textlabel           "CES1" ;
        gpml:type                "GeneProduct" ;
        gpml:valign              "Middle" ;
        gpml:width               "80.0"^^xsd:double ;
        gpml:xrefDataSource      "Ensembl" ;
        gpml:xrefId              "ENSG00000198848" ;
        gpml:zorder              "32768"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/fe3b3>
        rdf:type                 gpml:DataNode ;
        dcterms:isPartOf         <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:align               "Center" ;
        gpml:biopaxRef           "db5" ;
        gpml:centerX             "451.6268211124266"^^xsd:double ;
        gpml:centerY             "196.75483323578385"^^xsd:double ;
        gpml:color               "cc00" ;
        gpml:fillColor           "ffffff" ;
        gpml:fontDecoration      "Normal" ;
        gpml:fontName            "Arial" ;
        gpml:fontSize            "10.0"^^xsd:double ;
        gpml:fontStrikethru      "Normal" ;
        gpml:fontStyle           "Normal" ;
        gpml:fontWeight          "Normal" ;
        gpml:graphId             "fe3b3" ;
        gpml:hasComment          <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/1ed071423f270ddf8bce181155ab14d3> ;
        gpml:hasPublicationXref  <https://identifiers.org/pubmed/16778732> ;
        gpml:height              "20.0"^^xsd:double ;
        gpml:lineStyle           "Solid" ;
        gpml:lineThickness       "1.0"^^xsd:double ;
        gpml:shapeType           "Rectangle" ;
        gpml:textlabel           "CES2" ;
        gpml:type                "GeneProduct" ;
        gpml:valign              "Middle" ;
        gpml:width               "80.0"^^xsd:double ;
        gpml:xrefDataSource      "Ensembl" ;
        gpml:xrefId              "ENSG00000172831" ;
        gpml:zorder              "32770"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ide473476/Point/6833ea167c272e9411685b9f1affdf78>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/ide473476> ;
        gpml:graphRef     "c446d" ;
        gpml:relX         "1.0"^^xsd:double ;
        gpml:relY         "0.0"^^xsd:double ;
        gpml:x            "276.6268211124266"^^xsd:double ;
        gpml:y            "228.31038879133942"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/f1e6651957b55afc9c142fa8db00ab5f>
        rdf:type          gpml:Comment ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/a5b38> ;
        gpml:commentText  "pseudocholinesterase" .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/idee25ceb0>
        rdf:type                 gpml:Interaction ;
        dcterms:isPartOf         <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:biopaxRef           "ca0" ;
        gpml:color               "0" ;
        gpml:connectorType       "Straight" ;
        gpml:graphId             "idee25ceb0" ;
        gpml:hasAnchor           <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/idee25ceb0/Anchor/fd293> ;
        gpml:hasPoint            <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/idee25ceb0/Point/593f1b15fd4b1d1801979be75fef2a46> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/idee25ceb0/Point/8a6518d8d1eb2d223097b13c79a0d189> ;
        gpml:hasPublicationXref  <https://identifiers.org/pubmed/20649590> ;
        gpml:lineStyle           "Solid" ;
        gpml:lineThickness       "1.0"^^xsd:double ;
        gpml:zorder              "12288"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id3ad34204/Anchor/fb7ba>
        rdf:type          gpml:Anchor ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id3ad34204> ;
        gpml:graphId      "fb7ba" ;
        gpml:position     "0.5710533228263731"^^xsd:double ;
        gpml:shape        "None" .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Comment/7aaa8589fb7dd8b4490f96fa8bde3509>
        rdf:type          gpml:Comment ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/c446d> ;
        gpml:commentText  "catalyzed in liver" .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/DataNode/be981>
        rdf:type             gpml:DataNode ;
        dcterms:isPartOf     <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:align           "Center" ;
        gpml:centerX         "350.4334054745662"^^xsd:double ;
        gpml:centerY         "279.21573858557804"^^xsd:double ;
        gpml:color           "ff" ;
        gpml:fillColor       "ffffff" ;
        gpml:fontDecoration  "Normal" ;
        gpml:fontName        "Arial" ;
        gpml:fontSize        "10.0"^^xsd:double ;
        gpml:fontStrikethru  "Normal" ;
        gpml:fontStyle       "Normal" ;
        gpml:fontWeight      "Normal" ;
        gpml:graphId         "be981" ;
        gpml:height          "20.0"^^xsd:double ;
        gpml:lineStyle       "Solid" ;
        gpml:lineThickness   "1.0"^^xsd:double ;
        gpml:shapeType       "Rectangle" ;
        gpml:textlabel       "morphine" ;
        gpml:type            "Metabolite" ;
        gpml:valign          "Middle" ;
        gpml:width           "80.0"^^xsd:double ;
        gpml:xrefDataSource  "ChEBI" ;
        gpml:xrefId          "CHEBI:17303" ;
        gpml:zorder          "32768"^^xsd:long .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id295fda1b/Point/c1cc9446085c4cae045f26cf77525212>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id295fda1b> ;
        gpml:graphRef     "cdf04" ;
        gpml:relX         "0.5"^^xsd:double ;
        gpml:relY         "-1.0"^^xsd:double ;
        gpml:x            "154.79554539226234"^^xsd:double ;
        gpml:y            "155.21573858557792"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id4ec3ed81/Anchor/db077>
        rdf:type          gpml:Anchor ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id4ec3ed81> ;
        gpml:graphId      "db077" ;
        gpml:position     "0.48088684919065844"^^xsd:double ;
        gpml:shape        "None" .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id827ed290/Point/97b6d8f4be3056556197fb5410447e25>
        rdf:type          gpml:Point ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP2645_r139960> , <http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id827ed290> ;
        gpml:graphRef     "ec2c5" ;
        gpml:relX         "0.0"^^xsd:double ;
        gpml:relY         "-1.0"^^xsd:double ;
        gpml:x            "234.62682111242663"^^xsd:double ;
        gpml:y            "132.75483323578388"^^xsd:double .

<http://rdf.wikipathways.org/Pathway/WP2645_r139960/Interaction/id827ed290>
        rdf:type            gpml:Interaction ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2645_r139960> ;
        gpml:color          "0" ;
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