@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000198975>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7A2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198975> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198975" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198975> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406882> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7A2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18057999> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/ef82d> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198975> .

<https://identifiers.org/ensembl/ENSG00000181449>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SOX2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000181449> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000181449" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000181449> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6657> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SOX2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0U3FYV6> , <https://identifiers.org/uniprot/P48431> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031649> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/b6609> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0U3FYV6> , <http://purl.uniprot.org/uniprot/P48431> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000181449> .

<http://rdf.wikipathways.org/Pathway/WP3299_r88676/WP/Interaction/id38497fad>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3299_r88676/Interaction/id38497fad> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000120738> , <https://identifiers.org/ensembl/ENSG00000206557> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000206557> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000120738> .

<https://identifiers.org/ensembl/ENSG00000199072>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7F1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000199072> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000199072" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000199072> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406888> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7F1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058005> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/f9266> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000199072> .

<https://identifiers.org/ensembl/ENSG00000136997>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "c-MYC" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000136997> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000136997" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136997> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4609> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MYC> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q16591> , <https://identifiers.org/uniprot/P01106> , <https://identifiers.org/uniprot/A0A0B4J1R1> , <https://identifiers.org/uniprot/H0YBG3> , <https://identifiers.org/uniprot/A0A494C1T8> , <https://identifiers.org/uniprot/Q14899> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20969939> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/abe25> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A494C1T8> , <http://purl.uniprot.org/uniprot/H0YBG3> , <http://purl.uniprot.org/uniprot/Q16591> , <http://purl.uniprot.org/uniprot/Q14899> , <http://purl.uniprot.org/uniprot/A0A0B4J1R1> , <http://purl.uniprot.org/uniprot/P01106> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000136997> .

<https://identifiers.org/ensembl/ENSG00000136826>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KLF4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000136826> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000136826" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136826> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/9314> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KLF4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B7ZBT2> , <https://identifiers.org/uniprot/O43474> , <https://identifiers.org/uniprot/A0A087X0S4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18033993> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/b2c8e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/B7ZBT2> , <http://purl.uniprot.org/uniprot/A0A087X0S4> , <http://purl.uniprot.org/uniprot/O43474> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000136826> .

<https://identifiers.org/pmc/PMC7982796>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC7982796" ;
        cito:cites          <https://identifiers.org/wikipathways/WP3299> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC7982796> .

<https://identifiers.org/ensembl/ENSG00000120738>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "EGR1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000120738> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000120738" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> , <http://rdf.wikipathways.org/Pathway/WP3299_r88676/WP/Interaction/id38497fad> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000120738> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1958> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EGR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P18146> , <https://identifiers.org/uniprot/Q546S1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14864821> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/ec30f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P18146> , <http://purl.uniprot.org/uniprot/Q546S1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000120738> .

<https://identifiers.org/ensembl/ENSG00000199133>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7D" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000199133> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000199133" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000199133> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406886> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7D> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058003> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/b5037> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000199133> .

<https://identifiers.org/ensembl/ENSG00000206557>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "LIN-41" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000206557> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000206557" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> , <http://rdf.wikipathways.org/Pathway/WP3299_r88676/WP/Interaction/id38497fad> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000206557> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/131405> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TRIM71> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q2Q1W2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18050104> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/c610c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q2Q1W2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000206557> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3299&oldid=88676>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/ensembl/ENSG00000199150>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7G" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000199150> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000199150" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000199150> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406890> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7G> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058008> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/b3b74> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000199150> .

<https://identifiers.org/ensembl/ENSG00000198972>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7E" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198972> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198972" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198972> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406887> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7E> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058004> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/bacae> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198972> .

<https://identifiers.org/ensembl/ENSG00000208012>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MIRLET7F2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000208012> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000208012" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000208012> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406889> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7F2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058006> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/d78e1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000208012> .

<https://identifiers.org/ensembl/ENSG00000199165>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7A1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000199165> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000199165" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000199165> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406881> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7A1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18057998> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/e09d2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000199165> .

<https://doi.org/10.1038%2Fs41598-024-70629-7>
        rdf:type            wp:PublicationReference ;
        dc:source           "DOI" ;
        dcterms:identifier  "10.1038/s41598-024-70629-7" ;
        cito:cites          <https://identifiers.org/wikipathways/WP3299> .

<https://identifiers.org/ncbigene/5460>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "OCT4" ;
        dc:identifier       <https://identifiers.org/ncbigene/5460> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5460" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000204531> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5460> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/POU5F1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F2Z381> , <https://identifiers.org/uniprot/M1S623> , <https://identifiers.org/uniprot/D2IYK3> , <https://identifiers.org/uniprot/Q01860> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/d5da0> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F2Z381> , <http://purl.uniprot.org/uniprot/M1S623> , <http://purl.uniprot.org/uniprot/D2IYK3> , <http://purl.uniprot.org/uniprot/Q01860> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5460> .

<https://identifiers.org/wikipathways/WP3299>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP3299_r88676> .

<https://identifiers.org/wikipathways/WP3299_r88676>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP3299> ;
        dc:source              "WikiPathways" ;
        dc:title               "let-7 inhibition of ES cell reprogramming"@en ;
        dcterms:description    "Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)" ;
        dcterms:identifier     "WP3299" ;
        dcterms:references     <https://identifiers.org/pubmed/24239284> ;
        cito:cites             <https://identifiers.org/pubmed/24239284> ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP3299_r88676> ;
        wp:ontologyTag         obo:PW_0000004 , wp:Curation:AnalysisCollection ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000004 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3299&oldid=88676> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3299&oldid=88676> ;
        foaf:page              <http://www.wikipathways.org/instance/WP3299_r88676> .

<https://identifiers.org/ensembl/ENSG00000198986>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MIRLET7A3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198986> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198986" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198986> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/c5527> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198986> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/ensembl/ENSG00000199179>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MIRLET7I" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000199179> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000199179" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000199179> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406891> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7I> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058009> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/c3961> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000199179> .

<https://identifiers.org/pubmed/24239284>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "24239284" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/24239284> .

<https://identifiers.org/ensembl/ENSG00000199030>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MIRLET7C" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000199030> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000199030" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3299_r88676> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000199030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/406885> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MIRLET7C> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18058002> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3299_r88676/DataNode/dce25> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000199030> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3299&oldid=88676>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .
