@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/pubmed/16510598>
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        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/16510598> .

<https://identifiers.org/chemspider/5193>
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        rdfs:label          "Tegafur" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/WFWLQNSHRPWKFK-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/5193> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "5193" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:32188> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5193> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0246215> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/WFWLQNSHRPWKFK-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C12673> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5386> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q413370> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/c3c32> ;
        foaf:page           <https://www.chemspider.com/5193> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1601&oldid=142310>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/ncbigene/1066>
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        rdfs:label          "CES1" ;
        dc:identifier       <https://identifiers.org/ncbigene/1066> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1066" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198848> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1066> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CES1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BQV8> , <https://identifiers.org/uniprot/H3BQR4> , <https://identifiers.org/uniprot/H3BSU0> , <https://identifiers.org/uniprot/P23141> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/ddbcb> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H3BSU0> , <http://purl.uniprot.org/uniprot/H3BQV8> , <http://purl.uniprot.org/uniprot/H3BQR4> , <http://purl.uniprot.org/uniprot/P23141> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1066> .

<https://identifiers.org/pubmed/12724731>
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        dcterms:isPartOf    <https://identifiers.org/pubchem.compound/121997> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/12724731> .

<https://identifiers.org/pubmed/18992248>
        rdf:type            wp:PublicationReference ;
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18992248> .

<https://identifiers.org/pubmed/18035049>
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        dcterms:isPartOf    <https://identifiers.org/pubchem.compound/135403648> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18035049> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/idc4a8efbd>
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/idc4a8efbd> ;
        wp:participants   <https://identifiers.org/pubchem.compound/8642> .

<https://identifiers.org/pubmed/17549067>
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        dc:source           "PubMed" ;
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        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1805> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17549067> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/a56c3>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/a56c3> ;
        wp:participants   <https://identifiers.org/pubchem.compound/10255482> .

<https://identifiers.org/pubmed/15638735>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "15638735" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/7298> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/15638735> .

<https://identifiers.org/pubmed/14555507>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "14555507" ;
        dcterms:isPartOf    <https://identifiers.org/pubchem.compound/121997> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/14555507> .

<https://doi.org/10.1211%2F0022357055966>
        dc:source           "DOI" ;
        dcterms:identifier  "10.1211/0022357055966" .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/ida6d98cef>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/ida6d98cef> ;
        wp:participants   <https://identifiers.org/ncbigene/1890> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/ec0cc> ;
        wp:source         <https://identifiers.org/ncbigene/1890> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/ec0cc> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/idc86511af>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/idc86511af> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:46345> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id95afb06>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/id95afb06> ;
        wp:participants   <https://identifiers.org/ncbigene/10864> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id12aaa43> ;
        wp:source         <https://identifiers.org/ncbigene/10864> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id12aaa43> .

<https://identifiers.org/ncbigene/8824>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CES2" ;
        dc:identifier       <https://identifiers.org/ncbigene/8824> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "8824" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000172831> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/8824> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CES2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3QSC0> , <https://identifiers.org/uniprot/J3QLP1> , <https://identifiers.org/uniprot/H3BUN5> , <https://identifiers.org/uniprot/O00748> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/fffc8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3QLP1> , <http://purl.uniprot.org/uniprot/O00748> , <http://purl.uniprot.org/uniprot/H3BUN5> , <http://purl.uniprot.org/uniprot/J3QSC0> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/8824> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/af4d8>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/af4d8> ;
        wp:participants   <https://identifiers.org/pubchem.compound/151244> , <https://identifiers.org/pubchem.compound/121997> ;
        wp:source         <https://identifiers.org/pubchem.compound/121997> ;
        wp:target         <https://identifiers.org/pubchem.compound/151244> .

<https://identifiers.org/pubmed/18607850>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "18607850" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/7298> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18607850> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/a4d67>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/a4d67> ;
        wp:participants   <https://identifiers.org/cas/796-66-7> , <https://identifiers.org/chebi/CHEBI:46345> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:46345> ;
        wp:target         <https://identifiers.org/cas/796-66-7> .

<https://identifiers.org/ncbigene/6241>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RRM2" ;
        dc:identifier       <https://identifiers.org/ncbigene/6241> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6241" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171848> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6241> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RRM2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P31350> , <https://identifiers.org/uniprot/A0A2R8Y837> , <https://identifiers.org/uniprot/A0A7P0SBL1> , <https://identifiers.org/uniprot/A0A286YFD6> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/ec794> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P31350> , <http://purl.uniprot.org/uniprot/A0A286YFD6> , <http://purl.uniprot.org/uniprot/A0A7P0SBL1> , <http://purl.uniprot.org/uniprot/A0A2R8Y837> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6241> .

<https://identifiers.org/pubmed/11956089>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "11956089" ;
        dcterms:isPartOf    <https://identifiers.org/wikidata/Q1253473> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/11956089> .

<https://identifiers.org/pubchem.compound/121997>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "DHFU" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/RAIRJKWTBBDDAR-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/121997> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "121997" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id687eee0a> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/af4d8> , <https://identifiers.org/wikipathways/WP1601_r142310> ;
        dcterms:references  <https://identifiers.org/pubmed/12724731> , <https://identifiers.org/pubmed/14555507> , <https://identifiers.org/pubmed/18075467> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:80624> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/108825> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0060402> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/RAIRJKWTBBDDAR-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C16630> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID121997> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27149672> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/fde63> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=121997> .

<https://identifiers.org/pubchem.compound/13351>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "FBAL" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/OJQNRNQELNLWHH-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/13351> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "13351" ;
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        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:80626> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/12782> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/OJQNRNQELNLWHH-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C16632> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID13351> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27149674> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/df25b> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=13351> .

<https://identifiers.org/ncbigene/151531>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "UPP2" ;
        dc:identifier       <https://identifiers.org/ncbigene/151531> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "151531" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000007001> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/151531> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/UPP2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0S2Z634> , <https://identifiers.org/uniprot/O95045> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/c67ea> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/f6b42> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O95045> , <http://purl.uniprot.org/uniprot/A0A0S2Z634> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/151531> .

<https://identifiers.org/pubmed/18820913>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "18820913" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/9429> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18820913> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id33e21efd>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/id33e21efd> ;
        wp:participants   <https://identifiers.org/ncbigene/51733> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/b6257> ;
        wp:source         <https://identifiers.org/ncbigene/51733> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/b6257> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1601&oldid=142310>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/pubchem.compound/151244>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "FUPA" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FKTHAKABFGARQH-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/151244> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "151244" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/b6257> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/af4d8> , <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:80625> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/133299> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0060435> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/FKTHAKABFGARQH-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C16631> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID151244> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27149673> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/ae234> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=151244> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id76e83284>
        rdf:type            wp:DirectedInteraction , wp:Interaction , wp:Inhibition ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        dcterms:references  <https://identifiers.org/pubmed/18390668> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/id76e83284> ;
        wp:participants     <https://identifiers.org/ncbigene/6996> , <https://identifiers.org/ensembl/ENSG00000284214> ;
        wp:source           <https://identifiers.org/ensembl/ENSG00000284214> ;
        wp:target           <https://identifiers.org/ncbigene/6996> .

<https://identifiers.org/ncbigene/2356>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FPGS" ;
        dc:identifier       <https://identifiers.org/ncbigene/2356> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2356" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136877> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2356> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FPGS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5JU21> , <https://identifiers.org/uniprot/Q5JU23> , <https://identifiers.org/uniprot/Q5JU20> , <https://identifiers.org/uniprot/Q05932> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/cfb65> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q05932> , <http://purl.uniprot.org/uniprot/Q5JU21> , <http://purl.uniprot.org/uniprot/Q5JU23> , <http://purl.uniprot.org/uniprot/Q5JU20> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2356> .

<https://identifiers.org/ncbigene/7517>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "XRCC3" ;
        dc:identifier       <https://identifiers.org/ncbigene/7517> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7517" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000126215> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7517> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/XRCC3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V2P3> , <https://identifiers.org/uniprot/G3V2L7> , <https://identifiers.org/uniprot/G3V3H9> , <https://identifiers.org/uniprot/G3V3Q2> , <https://identifiers.org/uniprot/G3V5K0> , <https://identifiers.org/uniprot/G3V399> , <https://identifiers.org/uniprot/Q53XC8> , <https://identifiers.org/uniprot/O43542> , <https://identifiers.org/uniprot/G3V3C8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/d9c06> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V399> , <http://purl.uniprot.org/uniprot/G3V2P3> , <http://purl.uniprot.org/uniprot/G3V3Q2> , <http://purl.uniprot.org/uniprot/G3V3H9> , <http://purl.uniprot.org/uniprot/G3V3C8> , <http://purl.uniprot.org/uniprot/O43542> , <http://purl.uniprot.org/uniprot/G3V5K0> , <http://purl.uniprot.org/uniprot/G3V2L7> , <http://purl.uniprot.org/uniprot/Q53XC8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7517> .

<https://identifiers.org/ncbigene/83549>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "UCK1" ;
        dc:identifier       <https://identifiers.org/ncbigene/83549> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "83549" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130717> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/83549> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/UCK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9HA47> , <https://identifiers.org/uniprot/G3V170> , <https://identifiers.org/uniprot/A0A024R8E7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/d9856> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V170> , <http://purl.uniprot.org/uniprot/A0A024R8E7> , <http://purl.uniprot.org/uniprot/Q9HA47> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/83549> .

<https://identifiers.org/ncbigene/1807>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "DPYS" ;
        dc:identifier       <https://identifiers.org/ncbigene/1807> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1807" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id851cbe0e> , <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000147647> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1807> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DPYS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q14117> , <https://identifiers.org/uniprot/E5RG28> , <https://identifiers.org/uniprot/H0YEV7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/d356e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E5RG28> , <http://purl.uniprot.org/uniprot/Q14117> , <http://purl.uniprot.org/uniprot/H0YEV7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1807> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/b6257>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/b6257> ;
        wp:participants   <https://identifiers.org/pubchem.compound/13351> , <https://identifiers.org/pubchem.compound/151244> ;
        wp:source         <https://identifiers.org/pubchem.compound/151244> ;
        wp:target         <https://identifiers.org/pubchem.compound/13351> .

<https://identifiers.org/pubmed/19144510>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/19144510> .

<https://identifiers.org/wikipathways/WP1601_r142310>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP1601> ;
        dc:source               "WikiPathways" ;
        dc:title                "Fluoropyrimidine activity"@en ;
        dcterms:description     "The main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP), which inhibits the enzyme thymidylate synthase (TYMS). TYMS is an important part of the folate-homocysteine cycle and purine and pyrimidine synthesis. The conversion of 5-FU to FdUMP can occur via thymidylate phosphorylase (TYMP) to fluorodeoxyuridine (FUDR) and then by the action of thymidine kinase to FdUMP; or indirectly via fluorouridine monophosphate (FUMP) or fluroridine (FUR) to fluorouridine diphosphate (FUDP) and then ribonucleotide reductase action to FdUDP and FdUMP. FUDP and FdUDP can also be converted to FUTP and FdUTP and incorporated into RNA and DNA respectively which also contributes to the pharmacodynamic actions of fluoropyrimidines.\n\nSources: [PharmGKB:Fluoropyrimidine Pharmacokinetics](https://www.pharmgkb.org/pathway/PA150653776), [PharmGKB:Fluoropyrimidine Pharmacodynamics](https://www.pharmgkb.org/pathway/PA165291507), [Wikipedia:Fluorouracil](http://en.wikipedia.org/wiki/Fluorouracil).\n\nProteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP1601)." ;
        dcterms:identifier      "WP1601" ;
        dcterms:references      <https://identifiers.org/pubmed/16510598> , <https://identifiers.org/pubmed/19339911> , <https://identifiers.org/pubmed/19383847> , <https://identifiers.org/pubmed/8996164> , <https://identifiers.org/pubmed/15548681> , <https://identifiers.org/pubmed/19219653> , <https://identifiers.org/pubmed/15814641> , <https://identifiers.org/pubmed/16709241> , <https://identifiers.org/pubmed/16785472> , <https://identifiers.org/pubmed/19302291> , <https://identifiers.org/pubmed/19144510> , <https://identifiers.org/pubmed/2656050> ;
        cito:cites              <https://identifiers.org/pubmed/9849491> , <https://identifiers.org/pubmed/8996164> , <https://identifiers.org/pubmed/18820913> , <https://identifiers.org/pubmed/16510598> , <https://identifiers.org/pubmed/16709241> , <https://identifiers.org/pubmed/18035049> , <https://identifiers.org/pubmed/14555507> , <https://identifiers.org/pubmed/18075467> , <https://identifiers.org/pubmed/16785472> , <https://identifiers.org/pubmed/16267625> , <https://identifiers.org/pubmed/19339911> , <https://identifiers.org/pubmed/18267032> , <https://identifiers.org/pubmed/17283124> , <https://identifiers.org/pubmed/17549067> , <https://identifiers.org/pubmed/15548681> , <https://identifiers.org/pubmed/19302291> , <https://identifiers.org/pubmed/17695509> , <https://identifiers.org/pubmed/15814641> , <https://identifiers.org/pubmed/18607850> , <https://identifiers.org/pubmed/19093176> , <https://identifiers.org/pubmed/18837291> , <https://identifiers.org/pubmed/15638735> , <https://identifiers.org/pubmed/18992248> , <https://identifiers.org/pubmed/15901346> , <https://identifiers.org/pubmed/18390668> , <https://identifiers.org/pubmed/12724731> , <https://identifiers.org/pubmed/18498133> , <https://identifiers.org/pubmed/19144510> , <https://identifiers.org/pubmed/19383847> , <https://identifiers.org/pubmed/18357466> , <https://identifiers.org/pubmed/11956089> , <https://identifiers.org/pubmed/17716232> , <https://identifiers.org/pubmed/19402749> , <https://identifiers.org/pubmed/19219653> , <https://identifiers.org/pubmed/2656050> ;
        wp:cellTypeOntologyTag  obo:CL_0000182 ;
        wp:diseaseOntologyTag   obo:DOID_162 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP1601_r142310> ;
        wp:ontologyTag          wp:Curation:Diseases , wp:Curation:AnalysisCollection , wp:Curation:ExRNA , obo:DOID_162 , obo:PW_0000754 , obo:CL_0000182 , obo:PW_0000605 , wp:Curation:CPTAC ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000754 , obo:PW_0000605 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1601&oldid=142310> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1601&oldid=142310> ;
        foaf:page               <http://www.wikipathways.org/instance/WP1601_r142310> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id12aaa43>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/id12aaa43> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:46345> .

<https://identifiers.org/pubchem.compound/46936877>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "FUDP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/WLQBZMZTRNPUDL-BBVRLYRLSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/46936877> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "46936877" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/e34e6> , <https://identifiers.org/wikipathways/WP1601_r142310> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/abb6a> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/a234c> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/26330191> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/WLQBZMZTRNPUDL-BBVRLYRLSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID46936877> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27094920> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/d9509> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46936877> .

<https://identifiers.org/hmdb/HMDB0001409>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "dUMP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/JSRLJPSBLDHEIO-SHYZEUOFSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001409> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001409" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id72ecb3bd> , <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17622> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/58574> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001409> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/JSRLJPSBLDHEIO-SHYZEUOFSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00365> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID65063> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q2741362> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/d2ec5> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0001409> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/ec0cc>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/ec0cc> ;
        wp:participants   <https://identifiers.org/wikidata/Q5462356> , <https://identifiers.org/chebi/CHEBI:46345> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:46345> ;
        wp:target         <https://identifiers.org/wikidata/Q5462356> .

<https://identifiers.org/ncbigene/8836>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "GGH" ;
        dc:identifier       <https://identifiers.org/ncbigene/8836> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "8836" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137563> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/8836> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GGH> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2YQQ3> , <https://identifiers.org/uniprot/A0A7I2V5M0> , <https://identifiers.org/uniprot/Q92820> , <https://identifiers.org/uniprot/A0A7I2V5X9> , <https://identifiers.org/uniprot/A0A7I2V431> , <https://identifiers.org/uniprot/A0A7I2V5P2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/e259d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q92820> , <http://purl.uniprot.org/uniprot/A0A7I2V431> , <http://purl.uniprot.org/uniprot/A0A7I2YQQ3> , <http://purl.uniprot.org/uniprot/A0A7I2V5P2> , <http://purl.uniprot.org/uniprot/A0A7I2V5X9> , <http://purl.uniprot.org/uniprot/A0A7I2V5M0> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/8836> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/a234c>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/a234c> ;
        wp:participants   <https://identifiers.org/pubchem.compound/53882537> , <https://identifiers.org/pubchem.compound/46936877> ;
        wp:source         <https://identifiers.org/pubchem.compound/46936877> ;
        wp:target         <https://identifiers.org/pubchem.compound/53882537> .

<https://identifiers.org/ncbigene/2030>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SLC29A1" ;
        dc:identifier       <https://identifiers.org/ncbigene/2030> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2030" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> , <http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id459d15de> ;
        dcterms:references  <https://identifiers.org/pubmed/18992248> , <https://identifiers.org/pubmed/17695509> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000112759> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2030> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SLC29A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A2U3TZM5> , <https://identifiers.org/uniprot/A0A2R8YFB9> , <https://identifiers.org/uniprot/A0A2R8Y6D1> , <https://identifiers.org/uniprot/A0A2R8Y567> , <https://identifiers.org/uniprot/A0A2R8YFI6> , <https://identifiers.org/uniprot/A0A2R8Y801> , <https://identifiers.org/uniprot/A0A2U3TZM6> , <https://identifiers.org/uniprot/A0A2U3TZJ7> , <https://identifiers.org/uniprot/A0A2R8YEH8> , <https://identifiers.org/uniprot/Q99808> , <https://identifiers.org/uniprot/A0A2R8Y854> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/f3966> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A2U3TZM6> , <http://purl.uniprot.org/uniprot/A0A2R8YEH8> , <http://purl.uniprot.org/uniprot/Q99808> , <http://purl.uniprot.org/uniprot/A0A2R8Y567> , <http://purl.uniprot.org/uniprot/A0A2R8YFB9> , <http://purl.uniprot.org/uniprot/A0A2U3TZM5> , <http://purl.uniprot.org/uniprot/A0A2R8Y854> , <http://purl.uniprot.org/uniprot/A0A2U3TZJ7> , <http://purl.uniprot.org/uniprot/A0A2R8YFI6> , <http://purl.uniprot.org/uniprot/A0A2R8Y801> , <http://purl.uniprot.org/uniprot/A0A2R8Y6D1> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2030> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/d6b11>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/d6b11> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:46345> .

<https://identifiers.org/ncbigene/6240>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RRM1" ;
        dc:identifier       <https://identifiers.org/ncbigene/6240> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6240" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000167325> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6240> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RRM1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P23921> , <https://identifiers.org/uniprot/H0YCY7> , <https://identifiers.org/uniprot/E9PP77> , <https://identifiers.org/uniprot/E9PRY9> , <https://identifiers.org/uniprot/E9PJ62> , <https://identifiers.org/uniprot/E9PL69> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/d55e6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PRY9> , <http://purl.uniprot.org/uniprot/E9PP77> , <http://purl.uniprot.org/uniprot/E9PL69> , <http://purl.uniprot.org/uniprot/H0YCY7> , <http://purl.uniprot.org/uniprot/E9PJ62> , <http://purl.uniprot.org/uniprot/P23921> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6240> .

<https://identifiers.org/wikipathways/WP176>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "Folate Cycle" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP176> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP176" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1601_r142310> ;
        dcterms:references  <https://identifiers.org/pubmed/19093176> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1601_r142310/DataNode/db298> ;
        foaf:page           <https://www.wikipathways.org/instance/WP176> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/id1d1d218d>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1601_r142310> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1601_r142310/Interaction/id1d1d218d> ;
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        wp:source         <https://identifiers.org/pubchem.compound/8642> ;
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<https://identifiers.org/ncbigene/7372>
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<https://identifiers.org/pmc/PMC9015122>
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9015122> .

<https://identifiers.org/pubmed/18837291>
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18837291> .

<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/b7bd5>
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<https://identifiers.org/hmdb/HMDB0001056>
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<https://identifiers.org/wikipathways/WP1601>
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<https://identifiers.org/ensembl/ENSG00000284214>
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<https://identifiers.org/chemspider/97272>
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<https://identifiers.org/ncbigene/51733>
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<https://doi.org/10.3390%2Fcancers16122260>
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<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/ida833b0dc>
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<http://rdf.wikipathways.org/Pathway/WP1601_r142310/WP/Interaction/e34e6>
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<https://identifiers.org/wikipathways/WP1805>
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        rdfs:label          "DNA Repair" ;
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        foaf:page           <https://www.wikipathways.org/instance/WP1805> .

<https://identifiers.org/ncbigene/7083>
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        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7083> .
