@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/wikipathways/WP5076>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP5076_r137800> .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id5f19df3b>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/id5f19df3b> ;
        wp:participants   <https://identifiers.org/wikidata/Q106020256> .

<https://identifiers.org/ensembl/ENSG00000151694>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ADAM17" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000151694> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000151694" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idea3369fd> , <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000151694> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6868> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ADAM17> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A8K1B4> , <https://identifiers.org/uniprot/A0A3B3IST4> , <https://identifiers.org/uniprot/B2RNB2> , <https://identifiers.org/uniprot/A0A8V8TNK2> , <https://identifiers.org/uniprot/A0A8V8TNK7> , <https://identifiers.org/uniprot/A0A3B3ITB5> , <https://identifiers.org/uniprot/A0A8V8TPV7> , <https://identifiers.org/uniprot/A0A8V8TN27> , <https://identifiers.org/uniprot/A0A3B3ITW9> , <https://identifiers.org/uniprot/A0A8V8TPG8> , <https://identifiers.org/uniprot/A0A3B3ISQ1> , <https://identifiers.org/uniprot/P78536> , <https://identifiers.org/uniprot/A6H8L4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14907942> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/fc900> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A6H8L4> , <http://purl.uniprot.org/uniprot/A0A3B3ITW9> , <http://purl.uniprot.org/uniprot/A0A8V8TNK7> , <http://purl.uniprot.org/uniprot/A0A8V8TPV7> , <http://purl.uniprot.org/uniprot/A0A3B3ITB5> , <http://purl.uniprot.org/uniprot/P78536> , <http://purl.uniprot.org/uniprot/A0A3B3ISQ1> , <http://purl.uniprot.org/uniprot/A0A8V8TNK2> , <http://purl.uniprot.org/uniprot/A0A3B3IST4> , <http://purl.uniprot.org/uniprot/A0A8V8TN27> , <http://purl.uniprot.org/uniprot/A8K1B4> , <http://purl.uniprot.org/uniprot/A0A8V8TPG8> , <http://purl.uniprot.org/uniprot/B2RNB2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000151694> .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idf2233645>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/idf2233645> ;
        wp:participants   <https://identifiers.org/wikidata/Q106020256> .

<https://identifiers.org/ensembl/ENSG00000130234>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "sACE2" , "ACE2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000130234> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000130234" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id7040e5c9> , <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130234> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/59272> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACE2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V2E9> , <https://identifiers.org/uniprot/A0A7I2V5W5> , <https://identifiers.org/uniprot/A0A7I2V4H0> , <https://identifiers.org/uniprot/Q9BYF1> , <https://identifiers.org/uniprot/A0A7I2V3X6> , <https://identifiers.org/uniprot/A0A7I2V3N4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14875321> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/a86a2> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/faf44> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/d5a00> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/e6ff7> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/b70c4> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/e16f6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2V4H0> , <http://purl.uniprot.org/uniprot/A0A7I2V3X6> , <http://purl.uniprot.org/uniprot/Q9BYF1> , <http://purl.uniprot.org/uniprot/A0A7I2V3N4> , <http://purl.uniprot.org/uniprot/A0A7I2V5W5> , <http://purl.uniprot.org/uniprot/A0A7I2V2E9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000130234> .

<https://identifiers.org/hmdb/HMDB0001980>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Vasopressin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BJFIDCADFRDPIO-ZCCHBGLBSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001980> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001980" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001980> , <https://identifiers.org/hmdb/HMDB01980> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BJFIDCADFRDPIO-ZCCHBGLBSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00840> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID53477739> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q60496436> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/c696f> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/fec48> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/d63a3> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB01980> .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idea3369fd>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/idea3369fd> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000151694> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id7040e5c9> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000151694> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id7040e5c9> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5076&oldid=137800>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idbda85ec8>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/idbda85ec8> ;
        wp:participants   <https://identifiers.org/wikidata/Q106020256> .

<https://identifiers.org/wikipathways/WP5076_r137800>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP5076> ;
        dc:source              "WikiPathways" ;
        dc:title               "Soluble ACE2-mediated cell entry of SARS-CoV-2"@en ;
        dcterms:description    "ACE2 is a regulator of the renin-angiotensin system. To perform this function, ACE2 is transported to the cell surface, where it is cleaved by disintegrin and ADAM17 to produce an enzymatically active soluble form of ACE2. This soluble form retains the SARS-CoV-2 binding site. SARS-CoV-2 bound to either soluble ACE2 or soluble ACE2 and vasopressin then uses receptor-mediated endocytosis by through either AT1 or AVPR1B, respectively. \n\nThis figure is based on the graphical abstract from [Yeung et al.](https://www.cell.com/cell/fulltext/S0092-8674(21)00283-X)." ;
        dcterms:identifier     "WP5076" ;
        dcterms:references     <https://identifiers.org/pubmed/33713620> ;
        cito:cites             <https://identifiers.org/pubmed/33713620> ;
        wp:diseaseOntologyTag  obo:DOID_2945 , obo:DOID_0080600 , obo:DOID_934 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP5076_r137800> ;
        wp:ontologyTag         obo:DOID_934 , wp:Curation:AnalysisCollection , obo:DOID_2945 , wp:Curation:COVID19 , obo:DOID_0080600 , obo:PW_0000281 ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000281 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5076&oldid=137800> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5076&oldid=137800> ;
        foaf:page              <http://www.wikipathways.org/instance/WP5076_r137800> .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idc8983763>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/idc8983763> ;
        wp:participants   <https://identifiers.org/wikidata/Q106020256> .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id5e025fa9>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/id5e025fa9> ;
        wp:participants   <https://identifiers.org/wikidata/Q106020256> .

<https://identifiers.org/ensembl/ENSG00000144891>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AGTR1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000144891> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000144891" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000144891> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/185> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AGTR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D3DNG8> , <https://identifiers.org/uniprot/P30556> , <https://identifiers.org/uniprot/A0A0A0MSE3> , <https://identifiers.org/uniprot/Q53YY0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15332826> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/fcbf8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P30556> , <http://purl.uniprot.org/uniprot/D3DNG8> , <http://purl.uniprot.org/uniprot/A0A0A0MSE3> , <http://purl.uniprot.org/uniprot/Q53YY0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000144891> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5076&oldid=137800>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/wikidata/Q106020256>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "S1" ;
        dc:identifier       <https://identifiers.org/wikidata/Q106020256> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q106020256" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idf2233645> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id5e025fa9> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idc8983763> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idbda85ec8> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idadc90074> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id5f19df3b> , <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P0DTC2-PRO_0000449647> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q106020256> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/f39b1> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/e3dda> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/adc3a> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/e6625> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/d6ca7> , <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/e3b14> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P0DTC2-PRO_0000449647> ;
        foaf:page           <https://scholia.toolforge.org/Q106020256> .

<https://identifiers.org/pubmed/33713620>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "33713620" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5076_r137800> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/33713620> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/id7040e5c9>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/id7040e5c9> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130234> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000130234> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000130234> .

<https://identifiers.org/ensembl/ENSG00000198049>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "AVPR1B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198049> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198049" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198049> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/553> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AVPR1B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P47901> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14890030> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5076_r137800/DataNode/b6ae4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P47901> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198049> .

<http://rdf.wikipathways.org/Pathway/WP5076_r137800/WP/Interaction/idadc90074>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5076_r137800> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5076_r137800/Interaction/idadc90074> ;
        wp:participants   <https://identifiers.org/wikidata/Q106020256> .
