@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP3991_r92555/WP/Interaction/id2b0f2d35>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Interaction/id2b0f2d35> ;
        wp:participants   <https://identifiers.org/ensembl/ENSMUSG00000024563> ;
        wp:source         <https://identifiers.org/ensembl/ENSMUSG00000024563> ;
        wp:target         <https://identifiers.org/ensembl/ENSMUSG00000024563> .

<http://rdf.wikipathways.org/Pathway/WP3991_r92555/ComplexBinding/ca013>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Group/ca013> ;
        wp:participants   <https://identifiers.org/ensembl/ENSMUSG00000024563> , <https://identifiers.org/ensembl/ENSMUSG00000024515> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/ca013> .

<http://rdf.wikipathways.org/Pathway/WP3991_r92555/ComplexBinding/b84ee>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Group/b84ee> ;
        wp:participants   <https://identifiers.org/ensembl/ENSMUSG00000024563> , <https://identifiers.org/ensembl/ENSMUSG00000024515> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/b84ee> .

<https://identifiers.org/wikipathways/WP3991>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP3991_r92555> .

<https://identifiers.org/ensembl/ENSMUSG00000026124>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Cfc1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000026124> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000026124" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000026124> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/12627> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P97766> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q21839603> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/ef972> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P97766> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000026124> .

<https://identifiers.org/ensembl/ENSMUSG00000024515>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Smad4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000024515> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000024515" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/b84ee> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/ca013> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000024515> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/17128> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P97471> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14904155> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/d2463> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/a0cc6> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/c0deb> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P97471> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000024515> .

<https://identifiers.org/ensembl/ENSMUSG00000066652>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Lefty2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000066652> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000066652" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3991_r92555/WP/Interaction/id595b45b9> , <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000066652> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/320202> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P57785> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18301877> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/a8a2a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P57785> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000066652> .

<https://identifiers.org/pubmed/27072135>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "27072135" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/27072135> .

<https://identifiers.org/ncbigene/20997>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "T" ;
        dc:identifier       <https://identifiers.org/ncbigene/20997> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "20997" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000062327> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/21331> , <https://identifiers.org/ncbigene/20997> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BKU2> , <https://identifiers.org/uniprot/Q78ZW9> , <https://identifiers.org/uniprot/D3Z1X4> , <https://identifiers.org/uniprot/P20293> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/df89b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H3BKU2> , <http://purl.uniprot.org/uniprot/D3Z1X4> , <http://purl.uniprot.org/uniprot/Q78ZW9> , <http://purl.uniprot.org/uniprot/P20293> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/20997> .

<https://identifiers.org/ensembl/ENSMUSG00000037025>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Foxa2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000037025> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000037025" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000037025> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/15376> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P35583> , <https://identifiers.org/uniprot/G3UYH0> , <https://identifiers.org/uniprot/G5E8P5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18251249> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/b1efe> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3UYH0> , <http://purl.uniprot.org/uniprot/P35583> , <http://purl.uniprot.org/uniprot/G5E8P5> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000037025> .

<https://identifiers.org/ensembl/ENSMUSG00000037171>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Nodal" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000037171> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000037171" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000037171> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/18119> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P43021> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18252678> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/fb162> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P43021> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000037171> .

<https://identifiers.org/wikipathways/WP3991_r92555>
        rdf:type                wp:Pathway , skos:Collection ;
        dc:identifier           <https://identifiers.org/wikipathways/WP3991> ;
        dc:source               "WikiPathways" ;
        dc:title                "miR-127 in mesendoderm differentiation"@en ;
        dcterms:description     "Schematic representation depicts the mechanism of miR-127 in accelerating mesendoderm differentiation. miR-127, through the complementary pairing, suppresses the expression of Lefty2, which is referred to as antagonist to the nodal pathway. Thus, miR-127 induces p-Smad2 expression and finally up-regulates expression of mesendoderm markers." ;
        dcterms:identifier      "WP3991" ;
        dcterms:references      <https://identifiers.org/pubmed/27072135> ;
        cito:cites              <https://identifiers.org/pubmed/27072135> ;
        wp:cellTypeOntologyTag  obo:CL_0002322 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP3991_r92555> ;
        wp:ontologyTag          wp:Curation:AnalysisCollection , obo:CL_0002322 , wp:Curation:ExRNA , obo:PW_0000650 ;
        wp:organism             obo:NCBITaxon_10090 ;
        wp:organismName         "Mus musculus" ;
        wp:pathwayOntologyTag   obo:PW_0000650 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3991&oldid=92555> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3991&oldid=92555> ;
        foaf:page               <http://www.wikipathways.org/instance/WP3991_r92555> .

<https://identifiers.org/ensembl/ENSMUSG00000026836>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Acvr1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000026836> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000026836" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000026836> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/11477> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B1AW87> , <https://identifiers.org/uniprot/P37172> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905143> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/e09e9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P37172> , <http://purl.uniprot.org/uniprot/B1AW87> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000026836> .

<https://identifiers.org/ensembl/ENSMUSG00000070076>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mir127" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000070076> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000070076" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/WP/Interaction/id595b45b9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000070076> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/387146> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18304037> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/dd7b7> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000070076> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3991&oldid=92555>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3991&oldid=92555>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP3991_r92555/WP/Interaction/id595b45b9>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Interaction/id595b45b9> ;
        wp:participants   <https://identifiers.org/ensembl/ENSMUSG00000066652> , <https://identifiers.org/ensembl/ENSMUSG00000070076> ;
        wp:source         <https://identifiers.org/ensembl/ENSMUSG00000070076> ;
        wp:target         <https://identifiers.org/ensembl/ENSMUSG00000066652> .

obo:NCBITaxon_10090  obo:NCIT_C179773  "10090" .

<https://identifiers.org/ensembl/ENSMUSG00000052155>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Acvr2a" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000052155> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000052155" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000052155> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/11480> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P27038> , <https://identifiers.org/uniprot/A2AI38> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905171> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/bc4a9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A2AI38> , <http://purl.uniprot.org/uniprot/P27038> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000052155> .

<http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/ca013>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Group/ca013> ;
        wp:participants   <https://identifiers.org/ensembl/ENSMUSG00000024563> , <https://identifiers.org/ensembl/ENSMUSG00000024515> .

<http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/b84ee>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3991_r92555> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Group/b84ee> ;
        wp:participants   <https://identifiers.org/ensembl/ENSMUSG00000024563> , <https://identifiers.org/ensembl/ENSMUSG00000024515> .

<https://identifiers.org/ensembl/ENSMUSG00000024563>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Smad2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSMUSG00000024563> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSMUSG00000024563" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3991_r92555/WP/Interaction/id2b0f2d35> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/ca013> , <https://identifiers.org/wikipathways/WP3991_r92555> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/Complex/b84ee> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSMUSG00000024563> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/17126> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PZV6> , <https://identifiers.org/uniprot/E9PXA8> , <https://identifiers.org/uniprot/Q62432> , <https://identifiers.org/uniprot/E9Q5P9> , <https://identifiers.org/uniprot/E9Q3M0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14903947> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/d2eac> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/b7e0c> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/ffcac> , <http://rdf.wikipathways.org/Pathway/WP3991_r92555/DataNode/def20> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9Q3M0> , <http://purl.uniprot.org/uniprot/E9Q5P9> , <http://purl.uniprot.org/uniprot/E9PXA8> , <http://purl.uniprot.org/uniprot/Q62432> , <http://purl.uniprot.org/uniprot/E9PZV6> ;
        foaf:page           <https://www.ensembl.org/id/ENSMUSG00000024563> .
