@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3408&oldid=140811>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/ensembl/ENSG00000169174>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PCSK9" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000169174> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000169174" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/c6f4a> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/ffd3e> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id63132f7> , <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000169174> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/255738> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PCSK9> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A669KBG0> , <https://identifiers.org/uniprot/A0A669KAY4> , <https://identifiers.org/uniprot/A0A669KB81> , <https://identifiers.org/uniprot/Q8NBP7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q3359612> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/b152d> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/a3c40> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/c2f49> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A669KB81> , <http://purl.uniprot.org/uniprot/Q8NBP7> , <http://purl.uniprot.org/uniprot/A0A669KBG0> , <http://purl.uniprot.org/uniprot/A0A669KAY4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000169174> .

<https://doi.org/10.1211/PJ.2015.20068181>
        rdf:type          wp:PublicationReference ;
        dc:source         "DOI" ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        foaf:page         <https://doi.org/10.1211/PJ.2015.20068181> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/c6f4a>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Group/c6f4a> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130164> , <https://identifiers.org/chebi/CHEBI:47774> , <https://identifiers.org/ensembl/ENSG00000169174> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3408&oldid=140811>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/ComplexBinding/c6f4a>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Group/c6f4a> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130164> , <https://identifiers.org/chebi/CHEBI:47774> , <https://identifiers.org/ensembl/ENSG00000169174> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/c6f4a> .

<https://identifiers.org/wikipathways/WP3408>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP3408_r140811> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id16f07fa9>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Interaction/id16f07fa9> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130164> , <https://identifiers.org/chebi/CHEBI:47774> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:47774> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000130164> .

<https://identifiers.org/chebi/CHEBI:47774>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "LDL-C" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:47774> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:47774" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id81b28f13> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/bc284> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/c6f4a> , <https://identifiers.org/wikipathways/WP3408_r140811> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id16f07fa9> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:47774> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q75298271> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/b7c27> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/abfed> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/b3120> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/e17dd> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/be1bb> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:47774> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/bc284>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Group/bc284> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:47774> , <https://identifiers.org/ensembl/ENSG00000130164> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/ffd3e>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Group/ffd3e> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000169174> , <https://identifiers.org/ensembl/ENSG00000130164> .

<https://identifiers.org/wikipathways/WP3408_r140811>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP3408> ;
        dc:source               "WikiPathways" ;
        dc:title                "Evolocumab mechanism to reduce LDL cholesterol"@en ;
        dcterms:description     "Evolocumab (Repatha) is an injectable monoclonal antibody that reduces LDL cholesterol levels. A limited quantity of LDL cholesterol is extracted from circulative blood when PCSK9-bound LDLR is degraded upon internalization in liver cells. Evolocumab competitively binds PCSK9 away from LDLR complexes, which allows LDLR to be recycled, returning to the surface and clearing additional molecules of LDL cholesterol. " ;
        dcterms:identifier      "WP3408" ;
        dcterms:references      <https://doi.org/10.1211/PJ.2015.20068181> ;
        cito:cites              <https://doi.org/10.1211/PJ.2015.20068181> ;
        wp:cellTypeOntologyTag  obo:CL_0000182 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP3408_r140811> ;
        wp:ontologyTag          obo:PW_0000752 , obo:PW_0001347 , wp:Curation:AnalysisCollection , obo:PW_0000754 , obo:CL_0000182 , wp:Curation:Diseases ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0001347 , obo:PW_0000752 , obo:PW_0000754 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3408&oldid=140811> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3408&oldid=140811> ;
        foaf:page               <http://www.wikipathways.org/instance/WP3408_r140811> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/ComplexBinding/bc284>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Group/bc284> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:47774> , <https://identifiers.org/ensembl/ENSG00000130164> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/bc284> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id81b28f13>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Interaction/id81b28f13> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130164> , <https://identifiers.org/chebi/CHEBI:47774> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:47774> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000130164> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/ComplexBinding/ffd3e>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Group/ffd3e> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000169174> , <https://identifiers.org/ensembl/ENSG00000130164> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/ffd3e> .

<https://identifiers.org/wikidata/Q15623825>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Evolocumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q15623825> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q15623825" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id63132f7> , <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15623825> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/e93fb> ;
        foaf:page           <https://scholia.toolforge.org/Q15623825> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id9b84540a>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Interaction/id9b84540a> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130164> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000130164> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000130164> .

<http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id63132f7>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3408_r140811> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Interaction/id63132f7> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000169174> , <https://identifiers.org/wikidata/Q15623825> ;
        wp:source         <https://identifiers.org/wikidata/Q15623825> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000169174> .

<https://identifiers.org/ensembl/ENSG00000130164>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "LDLR" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000130164> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000130164" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/ffd3e> , <https://identifiers.org/wikipathways/WP3408_r140811> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id9b84540a> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/c6f4a> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/Complex/bc284> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id81b28f13> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/WP/Interaction/id16f07fa9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130164> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3949> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/LDLR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3KMZ9> , <https://identifiers.org/uniprot/A0A024R7D5> , <https://identifiers.org/uniprot/H0YMD1> , <https://identifiers.org/uniprot/H0YM92> , <https://identifiers.org/uniprot/P01130> , <https://identifiers.org/uniprot/H0YMQ3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14872724> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/d062f> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/be154> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/f97b1> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/d8784> , <http://rdf.wikipathways.org/Pathway/WP3408_r140811/DataNode/b27bc> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A024R7D5> , <http://purl.uniprot.org/uniprot/H0YMD1> , <http://purl.uniprot.org/uniprot/P01130> , <http://purl.uniprot.org/uniprot/H0YM92> , <http://purl.uniprot.org/uniprot/J3KMZ9> , <http://purl.uniprot.org/uniprot/H0YMQ3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000130164> .
