@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ncbigene/59>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ACTA2" ;
        dc:identifier       <https://identifiers.org/ncbigene/59> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "59" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000107796> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/59> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACTA2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P62736> , <https://identifiers.org/uniprot/D2JYH4> , <https://identifiers.org/uniprot/F6QUT6> , <https://identifiers.org/uniprot/F6UVQ4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/e42a5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F6UVQ4> , <http://purl.uniprot.org/uniprot/P62736> , <http://purl.uniprot.org/uniprot/F6QUT6> , <http://purl.uniprot.org/uniprot/D2JYH4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/59> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/fba40>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/fba40> ;
        wp:participants   <https://identifiers.org/ncbigene/4088> , <https://identifiers.org/ncbigene/7042> ;
        wp:source         <https://identifiers.org/ncbigene/7042> ;
        wp:target         <https://identifiers.org/ncbigene/4088> .

<https://identifiers.org/ncbigene/4088>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "SMAD3" ;
        dc:identifier       <https://identifiers.org/ncbigene/4088> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4088" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/fba40> , <https://identifiers.org/wikipathways/WP5545_r139134> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id11bd7f2> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id1ec4c874> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000166949> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4088> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SMAD3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BQ00> , <https://identifiers.org/uniprot/H3BP09> , <https://identifiers.org/uniprot/H0YL71> , <https://identifiers.org/uniprot/H0YMY0> , <https://identifiers.org/uniprot/H0YNV1> , <https://identifiers.org/uniprot/H0YKE2> , <https://identifiers.org/uniprot/A0A024R5Z3> , <https://identifiers.org/uniprot/H0YMP2> , <https://identifiers.org/uniprot/H3BVD1> , <https://identifiers.org/uniprot/P84022> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/cdeea> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H0YMY0> , <http://purl.uniprot.org/uniprot/H0YKE2> , <http://purl.uniprot.org/uniprot/H0YNV1> , <http://purl.uniprot.org/uniprot/H0YL71> , <http://purl.uniprot.org/uniprot/P84022> , <http://purl.uniprot.org/uniprot/H3BQ00> , <http://purl.uniprot.org/uniprot/H3BP09> , <http://purl.uniprot.org/uniprot/H3BVD1> , <http://purl.uniprot.org/uniprot/H0YMP2> , <http://purl.uniprot.org/uniprot/A0A024R5Z3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4088> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/idc2941205>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/idc2941205> ;
        wp:participants   <https://identifiers.org/ncbigene/4018> , <https://identifiers.org/ncbigene/5168> ;
        wp:source         <https://identifiers.org/ncbigene/5168> ;
        wp:target         <https://identifiers.org/ncbigene/4018> .

<https://identifiers.org/uniprot/Q8GYT9>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "SIS3" ;
        dc:identifier       <https://identifiers.org/uniprot/Q8GYT9> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q8GYT9" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id1ec4c874> , <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/AT3G47990> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/823954> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A178VFR3> , <https://identifiers.org/uniprot/A0A1I9LMR7> , <https://identifiers.org/uniprot/Q8GYT9> , <https://identifiers.org/uniprot/A0A5S9XIX1> , <https://identifiers.org/uniprot/A0A1I9LMR5> , <https://identifiers.org/uniprot/A0A654FFP7> , <https://identifiers.org/uniprot/A0A178VH98> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/e448a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A178VFR3> , <http://purl.uniprot.org/uniprot/A0A1I9LMR7> , <http://purl.uniprot.org/uniprot/A0A5S9XIX1> , <http://purl.uniprot.org/uniprot/A0A178VH98> , <http://purl.uniprot.org/uniprot/A0A1I9LMR5> , <http://purl.uniprot.org/uniprot/A0A654FFP7> , <http://purl.uniprot.org/uniprot/Q8GYT9> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q8GYT9> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id782dadbb>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/id782dadbb> ;
        wp:participants   <https://identifiers.org/ncbigene/6774> , <https://identifiers.org/ncbigene/7043> ;
        wp:source         <https://identifiers.org/ncbigene/7043> ;
        wp:target         <https://identifiers.org/ncbigene/6774> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5545&oldid=139134>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/ncbigene/6774>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "STAT3" ;
        dc:identifier       <https://identifiers.org/ncbigene/6774> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6774" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/e2dfe> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id782dadbb> , <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000168610> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6774> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STAT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V4F6> , <https://identifiers.org/uniprot/A0A7I2YQI1> , <https://identifiers.org/uniprot/A0A7I2V2T1> , <https://identifiers.org/uniprot/A0A7I2V3V0> , <https://identifiers.org/uniprot/A0A7I2V4R2> , <https://identifiers.org/uniprot/A0A7I2V395> , <https://identifiers.org/uniprot/A0A7I2V5N9> , <https://identifiers.org/uniprot/P40763> , <https://identifiers.org/uniprot/A0A7I2V444> , <https://identifiers.org/uniprot/A0A7I2V4C8> , <https://identifiers.org/uniprot/A0A7I2V4R3> , <https://identifiers.org/uniprot/A0A7I2V552> , <https://identifiers.org/uniprot/A0A7I2YQR5> , <https://identifiers.org/uniprot/A0A7I2V2G1> , <https://identifiers.org/uniprot/G8JLH9> , <https://identifiers.org/uniprot/A0A7I2YQD2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/e25da> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2YQI1> , <http://purl.uniprot.org/uniprot/P40763> , <http://purl.uniprot.org/uniprot/A0A7I2V5N9> , <http://purl.uniprot.org/uniprot/G8JLH9> , <http://purl.uniprot.org/uniprot/A0A7I2V4R3> , <http://purl.uniprot.org/uniprot/A0A7I2V3V0> , <http://purl.uniprot.org/uniprot/A0A7I2V4F6> , <http://purl.uniprot.org/uniprot/A0A7I2V444> , <http://purl.uniprot.org/uniprot/A0A7I2V395> , <http://purl.uniprot.org/uniprot/A0A7I2V2T1> , <http://purl.uniprot.org/uniprot/A0A7I2V4R2> , <http://purl.uniprot.org/uniprot/A0A7I2YQR5> , <http://purl.uniprot.org/uniprot/A0A7I2V552> , <http://purl.uniprot.org/uniprot/A0A7I2V4C8> , <http://purl.uniprot.org/uniprot/A0A7I2V2G1> , <http://purl.uniprot.org/uniprot/A0A7I2YQD2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6774> .

<https://identifiers.org/ncbigene/2335>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FN1" ;
        dc:identifier       <https://identifiers.org/ncbigene/2335> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2335" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115414> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2335> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FN1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0Y7Z1> , <https://identifiers.org/uniprot/P02751> , <https://identifiers.org/uniprot/H0Y4K8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/bce60> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P02751> , <http://purl.uniprot.org/uniprot/H0Y7Z1> , <http://purl.uniprot.org/uniprot/H0Y4K8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2335> .

<https://identifiers.org/pubmed/36139071>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "36139071" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/36139071> .

<https://identifiers.org/ncbigene/7043>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TGFB3" ;
        dc:identifier       <https://identifiers.org/ncbigene/7043> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7043" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id782dadbb> , <https://identifiers.org/wikipathways/WP5545_r139134> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/dc49e> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/a9943> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000119699> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7043> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFB3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P10600> , <https://identifiers.org/uniprot/A5YM40> , <https://identifiers.org/uniprot/A0A6Q8PGK5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/c5db2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A6Q8PGK5> , <http://purl.uniprot.org/uniprot/P10600> , <http://purl.uniprot.org/uniprot/A5YM40> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7043> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/e2dfe>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/e2dfe> ;
        wp:participants   <https://identifiers.org/ncbigene/5168> , <https://identifiers.org/ncbigene/6774> ;
        wp:source         <https://identifiers.org/ncbigene/6774> ;
        wp:target         <https://identifiers.org/ncbigene/5168> .

<https://identifiers.org/ncbigene/6010>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RHO" ;
        dc:identifier       <https://identifiers.org/ncbigene/6010> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6010" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/e8366> , <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000163914> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6010> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RHO> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P08100> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/a3e09> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P08100> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6010> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id11bd7f2>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/id11bd7f2> ;
        wp:participants   <https://identifiers.org/ncbigene/5168> , <https://identifiers.org/ncbigene/4088> ;
        wp:source         <https://identifiers.org/ncbigene/4088> ;
        wp:target         <https://identifiers.org/ncbigene/5168> .

<https://identifiers.org/ncbigene/7042>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TGFB2" ;
        dc:identifier       <https://identifiers.org/ncbigene/7042> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7042" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/dc49e> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/fba40> , <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000092969> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7042> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P61812> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/aaf88> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P61812> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7042> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/a9943>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/a9943> ;
        wp:participants   <https://identifiers.org/ncbigene/7040> , <https://identifiers.org/ncbigene/7043> ;
        wp:source         <https://identifiers.org/ncbigene/7043> ;
        wp:target         <https://identifiers.org/ncbigene/7040> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/dc49e>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/dc49e> ;
        wp:participants   <https://identifiers.org/ncbigene/7042> , <https://identifiers.org/ncbigene/7043> ;
        wp:source         <https://identifiers.org/ncbigene/7043> ;
        wp:target         <https://identifiers.org/ncbigene/7042> .

<https://identifiers.org/ncbigene/1490>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CCN2" ;
        dc:identifier       <https://identifiers.org/ncbigene/1490> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1490" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118523> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1490> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CCN2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P29279> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/c4dbe> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P29279> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1490> .

<https://identifiers.org/ncbigene/5602>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MAPK10" ;
        dc:identifier       <https://identifiers.org/ncbigene/5602> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5602" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000109339> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5602> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK10> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A286YFI3> , <https://identifiers.org/uniprot/A0A286YEV5> , <https://identifiers.org/uniprot/A0A286YF35> , <https://identifiers.org/uniprot/D6RDG1> , <https://identifiers.org/uniprot/A0A286YFJ6> , <https://identifiers.org/uniprot/A0A286YEW9> , <https://identifiers.org/uniprot/A0A286YFC3> , <https://identifiers.org/uniprot/A0A286YF85> , <https://identifiers.org/uniprot/A0A286YFJ4> , <https://identifiers.org/uniprot/F8W9R5> , <https://identifiers.org/uniprot/A0A286YFJ0> , <https://identifiers.org/uniprot/A0A286YEQ0> , <https://identifiers.org/uniprot/A0A286YF83> , <https://identifiers.org/uniprot/A0A1W2PPZ3> , <https://identifiers.org/uniprot/D6RBH2> , <https://identifiers.org/uniprot/D6RFX8> , <https://identifiers.org/uniprot/A0A286YF02> , <https://identifiers.org/uniprot/A0A286YES9> , <https://identifiers.org/uniprot/A0A286YEY2> , <https://identifiers.org/uniprot/A0A286YEV8> , <https://identifiers.org/uniprot/A0A286YFA7> , <https://identifiers.org/uniprot/A0A1W2PNF5> , <https://identifiers.org/uniprot/A0A286YFE2> , <https://identifiers.org/uniprot/A0A286YF53> , <https://identifiers.org/uniprot/A0A1W2PQX4> , <https://identifiers.org/uniprot/A0A286YF43> , <https://identifiers.org/uniprot/A0A286YFB7> , <https://identifiers.org/uniprot/A0A286YEW4> , <https://identifiers.org/uniprot/A0A286YF80> , <https://identifiers.org/uniprot/D6R9C1> , <https://identifiers.org/uniprot/A0A1P0B7D2> , <https://identifiers.org/uniprot/A0A286YES0> , <https://identifiers.org/uniprot/A0A286YF19> , <https://identifiers.org/uniprot/A0A286YEZ1> , <https://identifiers.org/uniprot/A0A286YFA3> , <https://identifiers.org/uniprot/D6RC26> , <https://identifiers.org/uniprot/A0A286YFB6> , <https://identifiers.org/uniprot/A0A286YF95> , <https://identifiers.org/uniprot/A0A286YFK3> , <https://identifiers.org/uniprot/A0A1W2PPW1> , <https://identifiers.org/uniprot/A0A286YEY0> , <https://identifiers.org/uniprot/A0A286YES8> , <https://identifiers.org/uniprot/D6RJF9> , <https://identifiers.org/uniprot/A0A286YFA6> , <https://identifiers.org/uniprot/A8MPV1> , <https://identifiers.org/uniprot/A0A286YEQ7> , <https://identifiers.org/uniprot/A0A286YEV3> , <https://identifiers.org/uniprot/A0A1W2PPM4> , <https://identifiers.org/uniprot/A0A286YFC0> , <https://identifiers.org/uniprot/D6RAJ0> , <https://identifiers.org/uniprot/A0A1W2PQ03> , <https://identifiers.org/uniprot/A0A286YF04> , <https://identifiers.org/uniprot/A0A286YFN2> , <https://identifiers.org/uniprot/D6RCB1> , <https://identifiers.org/uniprot/A0A286YFD9> , <https://identifiers.org/uniprot/A0A286YF62> , <https://identifiers.org/uniprot/A0A1W2PRZ2> , <https://identifiers.org/uniprot/A0A286YFM6> , <https://identifiers.org/uniprot/A0A1W2PRF2> , <https://identifiers.org/uniprot/A0A1W2PRG9> , <https://identifiers.org/uniprot/A0A286YF97> , <https://identifiers.org/uniprot/A0A286YEX7> , <https://identifiers.org/uniprot/P53779> , <https://identifiers.org/uniprot/D6RFZ7> , <https://identifiers.org/uniprot/A0A286YFD7> , <https://identifiers.org/uniprot/A0A286YFE9> , <https://identifiers.org/uniprot/A0A286YFH4> , <https://identifiers.org/uniprot/A0A286YEN5> , <https://identifiers.org/uniprot/D6RAU3> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/fa1e0> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D6RFZ7> , <http://purl.uniprot.org/uniprot/A0A286YF35> , <http://purl.uniprot.org/uniprot/A0A286YFH4> , <http://purl.uniprot.org/uniprot/A0A286YFM6> , <http://purl.uniprot.org/uniprot/A0A1P0B7D2> , <http://purl.uniprot.org/uniprot/A0A1W2PPW1> , <http://purl.uniprot.org/uniprot/D6RAU3> , <http://purl.uniprot.org/uniprot/A0A286YF80> , <http://purl.uniprot.org/uniprot/A0A286YF02> , <http://purl.uniprot.org/uniprot/A0A286YFC3> , <http://purl.uniprot.org/uniprot/A0A286YES8> , <http://purl.uniprot.org/uniprot/A0A286YFA7> , <http://purl.uniprot.org/uniprot/A0A286YEY2> , <http://purl.uniprot.org/uniprot/A0A286YFD7> , <http://purl.uniprot.org/uniprot/A0A286YES9> , <http://purl.uniprot.org/uniprot/A0A1W2PNF5> , <http://purl.uniprot.org/uniprot/D6RBH2> , <http://purl.uniprot.org/uniprot/A0A286YF53> , <http://purl.uniprot.org/uniprot/A0A286YES0> , <http://purl.uniprot.org/uniprot/A0A286YEN5> , <http://purl.uniprot.org/uniprot/A0A1W2PRZ2> , <http://purl.uniprot.org/uniprot/A0A286YF43> , <http://purl.uniprot.org/uniprot/A0A286YEZ1> , <http://purl.uniprot.org/uniprot/A0A286YFA3> , <http://purl.uniprot.org/uniprot/A0A286YF83> , <http://purl.uniprot.org/uniprot/A0A286YFJ4> , <http://purl.uniprot.org/uniprot/A0A286YFE9> , <http://purl.uniprot.org/uniprot/A0A1W2PQX4> , <http://purl.uniprot.org/uniprot/A0A286YFB7> , <http://purl.uniprot.org/uniprot/A0A286YFK3> , <http://purl.uniprot.org/uniprot/A0A286YF95> , <http://purl.uniprot.org/uniprot/A0A286YF85> , <http://purl.uniprot.org/uniprot/D6RCB1> , <http://purl.uniprot.org/uniprot/A0A286YFB6> , <http://purl.uniprot.org/uniprot/A0A1W2PPZ3> , <http://purl.uniprot.org/uniprot/A0A286YF04> , <http://purl.uniprot.org/uniprot/A0A286YFE2> , <http://purl.uniprot.org/uniprot/A0A1W2PRF2> , <http://purl.uniprot.org/uniprot/A0A286YF97> , <http://purl.uniprot.org/uniprot/A0A286YEX7> , <http://purl.uniprot.org/uniprot/A0A286YFD9> , <http://purl.uniprot.org/uniprot/D6R9C1> , <http://purl.uniprot.org/uniprot/A0A286YFJ0> , <http://purl.uniprot.org/uniprot/F8W9R5> , <http://purl.uniprot.org/uniprot/P53779> , <http://purl.uniprot.org/uniprot/A0A286YFI3> , <http://purl.uniprot.org/uniprot/A0A286YEV3> , <http://purl.uniprot.org/uniprot/A0A1W2PQ03> , <http://purl.uniprot.org/uniprot/A0A286YEQ7> , <http://purl.uniprot.org/uniprot/A0A286YEY0> , <http://purl.uniprot.org/uniprot/A0A286YFJ6> , <http://purl.uniprot.org/uniprot/A0A286YFA6> , <http://purl.uniprot.org/uniprot/D6RJF9> , <http://purl.uniprot.org/uniprot/A0A286YEW4> , <http://purl.uniprot.org/uniprot/D6RDG1> , <http://purl.uniprot.org/uniprot/D6RFX8> , <http://purl.uniprot.org/uniprot/A8MPV1> , <http://purl.uniprot.org/uniprot/A0A286YEW9> , <http://purl.uniprot.org/uniprot/A0A286YFC0> , <http://purl.uniprot.org/uniprot/A0A286YEV5> , <http://purl.uniprot.org/uniprot/A0A286YF62> , <http://purl.uniprot.org/uniprot/A0A286YF19> , <http://purl.uniprot.org/uniprot/A0A1W2PPM4> , <http://purl.uniprot.org/uniprot/A0A286YEV8> , <http://purl.uniprot.org/uniprot/D6RAJ0> , <http://purl.uniprot.org/uniprot/A0A286YEQ0> , <http://purl.uniprot.org/uniprot/A0A286YFN2> , <http://purl.uniprot.org/uniprot/D6RC26> , <http://purl.uniprot.org/uniprot/A0A1W2PRG9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5602> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id1ec4c874>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/id1ec4c874> ;
        wp:participants   <https://identifiers.org/ncbigene/4088> , <https://identifiers.org/uniprot/Q8GYT9> ;
        wp:source         <https://identifiers.org/uniprot/Q8GYT9> ;
        wp:target         <https://identifiers.org/ncbigene/4088> .

<https://identifiers.org/wikipathways/WP5545_r139134>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP5545> ;
        dc:source               "WikiPathways" ;
        dc:title                "Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor"@en ;
        dcterms:description     "This pathway visualises the potential mechanisms of TGF-β3-mediated ENPP2 (or ATX) expression and fibrotic changes in HTM cells. This pathway was created using the PFOCR project, based on [these results](https://pfocr.wikipathways.org/figures/PMC9496180__biomolecules-12-01231-g008.html)." ;
        dcterms:identifier      "WP5545" ;
        dcterms:references      <https://identifiers.org/pubmed/36139071> ;
        cito:cites              <https://identifiers.org/pubmed/36139071> ;
        wp:cellTypeOntologyTag  obo:CL_0002367 ;
        wp:diseaseOntologyTag   obo:DOID_1686 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP5545_r139134> ;
        wp:ontologyTag          wp:Curation:AnalysisCollection , obo:PW_0000206 , obo:CL_0002367 , obo:PW_0000003 , obo:DOID_1686 ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000206 , obo:PW_0000003 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5545&oldid=139134> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5545&oldid=139134> ;
        foaf:page               <http://www.wikipathways.org/instance/WP5545_r139134> .

<https://identifiers.org/ncbigene/4018>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "LPA" ;
        dc:identifier       <https://identifiers.org/ncbigene/4018> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4018" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/idc2941205> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/e8366> , <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198670> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4018> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/LPA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P08519> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/bf517> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P08519> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4018> .

<https://identifiers.org/ncbigene/5599>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK8" ;
        dc:identifier       <https://identifiers.org/ncbigene/5599> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5599" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000107643> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5599> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK8> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A3B3IRW7> , <https://identifiers.org/uniprot/C9J762> , <https://identifiers.org/uniprot/A1L4K2> , <https://identifiers.org/uniprot/C9JWQ4> , <https://identifiers.org/uniprot/P45983> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/c8496> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9JWQ4> , <http://purl.uniprot.org/uniprot/C9J762> , <http://purl.uniprot.org/uniprot/A0A3B3IRW7> , <http://purl.uniprot.org/uniprot/P45983> , <http://purl.uniprot.org/uniprot/A1L4K2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5599> .

<https://identifiers.org/ncbigene/5168>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ENPP2" ;
        dc:identifier       <https://identifiers.org/ncbigene/5168> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5168" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/id11bd7f2> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/idc2941205> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/e2dfe> , <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136960> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5168> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ENPP2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E5RIA2> , <https://identifiers.org/uniprot/Q13822> , <https://identifiers.org/uniprot/E7EUF1> , <https://identifiers.org/uniprot/E5RJ49> , <https://identifiers.org/uniprot/E5RIB9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/d0135> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E5RJ49> , <http://purl.uniprot.org/uniprot/Q13822> , <http://purl.uniprot.org/uniprot/E5RIA2> , <http://purl.uniprot.org/uniprot/E7EUF1> , <http://purl.uniprot.org/uniprot/E5RIB9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5168> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/wikipathways/WP5545>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP5545_r139134> .

<https://identifiers.org/ncbigene/7040>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TGFB1" ;
        dc:identifier       <https://identifiers.org/ncbigene/7040> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7040" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> , <http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/a9943> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105329> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7040> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A499FJK2> , <https://identifiers.org/uniprot/A0A7I2V5Z9> , <https://identifiers.org/uniprot/A0A7I2YQL8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/d7a95> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2YQL8> , <http://purl.uniprot.org/uniprot/A0A7I2V5Z9> , <http://purl.uniprot.org/uniprot/A0A499FJK2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7040> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5545&oldid=139134>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/ncbigene/5601>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK9" ;
        dc:identifier       <https://identifiers.org/ncbigene/5601> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5601" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000050748> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5601> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK9> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P45984> , <https://identifiers.org/uniprot/D7R525> , <https://identifiers.org/uniprot/D7R528> , <https://identifiers.org/uniprot/E5RJ57> , <https://identifiers.org/uniprot/J3KNK1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/c9771> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E5RJ57> , <http://purl.uniprot.org/uniprot/D7R525> , <http://purl.uniprot.org/uniprot/J3KNK1> , <http://purl.uniprot.org/uniprot/P45984> , <http://purl.uniprot.org/uniprot/D7R528> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5601> .

<http://rdf.wikipathways.org/Pathway/WP5545_r139134/WP/Interaction/e8366>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5545_r139134/Interaction/e8366> ;
        wp:participants   <https://identifiers.org/ncbigene/6010> , <https://identifiers.org/ncbigene/4018> ;
        wp:source         <https://identifiers.org/ncbigene/4018> ;
        wp:target         <https://identifiers.org/ncbigene/6010> .

<https://identifiers.org/ncbigene/1277>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "COL1A1" ;
        dc:identifier       <https://identifiers.org/ncbigene/1277> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1277" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5545_r139134> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000108821> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1277> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/COL1A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/I3L3H7> , <https://identifiers.org/uniprot/P02452> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5545_r139134/DataNode/f8cee> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/I3L3H7> , <http://purl.uniprot.org/uniprot/P02452> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1277> .
