@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ncbigene/6750>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SST" ;
        dc:identifier       <https://identifiers.org/ncbigene/6750> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6750" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id2f512d1> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000157005> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6750> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SST> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P61278> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/e0ed5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P61278> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6750> .

<https://identifiers.org/ncbiprotein/3972>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "LHB" ;
        dc:identifier       <https://identifiers.org/ncbiprotein/3972> ;
        dc:source           "NCBI Protein" ;
        dcterms:identifier  "3972" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id12ceef46> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id4932c3c9> , <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/e6ee0> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/protein/3972> .

<https://identifiers.org/chebi/CHEBI:50114>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Estrogens" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:50114> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:50114" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id46b63bd4> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id382a6039> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id12ceef46> , <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id5d5ecc9> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:50114> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q277954> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/f3e2e> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50114> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id30267f0c>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id30267f0c> ;
        wp:participants   <https://identifiers.org/ncbigene/3479> , <https://identifiers.org/ncbigene/2688> ;
        wp:source         <https://identifiers.org/ncbigene/2688> ;
        wp:target         <https://identifiers.org/ncbigene/3479> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4194&oldid=142017>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/wikipathways/WP4194_r142017>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP4194> ;
        dc:source              "WikiPathways" ;
        dc:title               "Hormonal control of pubertal growth spurt"@en ;
        dcterms:description    "This pathway shows the regulation and action of the GH-IGF-1 axis. Chondrogenesis in the growth plate is the biological process that drives height gain. The Growth hormone (GH) insulin-like growth factor 1 (IGF-1) axis is one of many regulatory systems that control chondrogenesis. Other hormones (estrogens, androgens), paracrine factors, extracellular matrix molecules and intracellular proteins regulate the activity of growth plate chondrocytes as well. Estrogen is critical for epiphyseal fusion in both young women, as well as men. This pathway describes how the growth plate lengthens until the epypheseal plate closure occurs. GH is released by the anterior pituitary gland due to the GRH. This activates IGF-1 in muscles and bones, and promotes lengthening of the growth plate. Also, GnRH in the hypothalamus stimulates LH and FSH in the anterior pituitary which stimulate gonads to produce sex hormones, such as estrogen." ;
        dcterms:identifier     "WP4194" ;
        dcterms:references     <https://identifiers.org/pubmed/12955018> ;
        cito:cites             <https://identifiers.org/pubmed/12955018> ;
        wp:diseaseOntologyTag  obo:DOID_6255 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP4194_r142017> ;
        wp:ontologyTag         wp:Curation:AnalysisCollection , obo:PW_0000238 , obo:PW_0000168 , obo:DOID_6255 ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000238 , obo:PW_0000168 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4194&oldid=142017> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4194&oldid=142017> ;
        foaf:page              <http://www.wikipathways.org/instance/WP4194_r142017> .

<https://identifiers.org/wikipathways/WP4194>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4194_r142017> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id64688f52>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id64688f52> ;
        wp:participants   <https://identifiers.org/ncbiprotein/449322> , <https://identifiers.org/ncbigene/2796> ;
        wp:source         <https://identifiers.org/ncbigene/2796> ;
        wp:target         <https://identifiers.org/ncbiprotein/449322> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id382a6039>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id382a6039> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:50114> , <https://identifiers.org/ncbiprotein/449322> ;
        wp:source         <https://identifiers.org/ncbiprotein/449322> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:50114> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id5d5ecc9>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id5d5ecc9> ;
        wp:participants   <https://identifiers.org/ncbigene/2688> , <https://identifiers.org/chebi/CHEBI:50114> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:50114> ;
        wp:target         <https://identifiers.org/ncbigene/2688> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id12ceef46>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id12ceef46> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:50114> , <https://identifiers.org/ncbiprotein/3972> ;
        wp:source         <https://identifiers.org/ncbiprotein/3972> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:50114> .

<https://identifiers.org/ncbigene/3479>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "IGF1" ;
        dc:identifier       <https://identifiers.org/ncbigene/3479> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "3479" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id30267f0c> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000017427> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3479> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IGF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P05019> , <https://identifiers.org/uniprot/Q5U743> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/a4244> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/c6b73> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5U743> , <http://purl.uniprot.org/uniprot/P05019> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/3479> .

<https://identifiers.org/ncbiprotein/449322>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "FSH" ;
        dc:identifier       <https://identifiers.org/ncbiprotein/449322> ;
        dc:source           "NCBI Protein" ;
        dcterms:identifier  "449322" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id64688f52> , <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id382a6039> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/a505b> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/protein/449322> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id7b083e52>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id7b083e52> ;
        wp:participants   <https://identifiers.org/ncbigene/2688> , <https://identifiers.org/ncbigene/2691> ;
        wp:source         <https://identifiers.org/ncbigene/2691> ;
        wp:target         <https://identifiers.org/ncbigene/2688> .

<https://identifiers.org/ncbigene/2688>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "GH1" ;
        dc:identifier       <https://identifiers.org/ncbigene/2688> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2688" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id5d5ecc9> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id2f512d1> , <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id7b083e52> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id30267f0c> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000259384> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2688> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GH1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B1A4G7> , <https://identifiers.org/uniprot/B1A4G6> , <https://identifiers.org/uniprot/B1A4G9> , <https://identifiers.org/uniprot/B1A4H0> , <https://identifiers.org/uniprot/P01241> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/a2306> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01241> , <http://purl.uniprot.org/uniprot/B1A4H0> , <http://purl.uniprot.org/uniprot/B1A4G6> , <http://purl.uniprot.org/uniprot/B1A4G9> , <http://purl.uniprot.org/uniprot/B1A4G7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2688> .

<https://identifiers.org/ncbigene/2691>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GHRH" ;
        dc:identifier       <https://identifiers.org/ncbigene/2691> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2691" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id7b083e52> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id46b63bd4> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118702> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2691> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GHRH> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01286> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/a62a8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01286> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2691> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id2f512d1>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id2f512d1> ;
        wp:participants   <https://identifiers.org/ncbigene/2688> , <https://identifiers.org/ncbigene/6750> ;
        wp:source         <https://identifiers.org/ncbigene/6750> ;
        wp:target         <https://identifiers.org/ncbigene/2688> .

<https://identifiers.org/ncbigene/2796>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GNRH1" ;
        dc:identifier       <https://identifiers.org/ncbigene/2796> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2796" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id64688f52> , <https://identifiers.org/wikipathways/WP4194_r142017> , <http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id4932c3c9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000147437> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2796> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GNRH1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01148> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4194_r142017/DataNode/d3d80> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01148> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2796> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id4932c3c9>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id4932c3c9> ;
        wp:participants   <https://identifiers.org/ncbiprotein/3972> , <https://identifiers.org/ncbigene/2796> ;
        wp:source         <https://identifiers.org/ncbigene/2796> ;
        wp:target         <https://identifiers.org/ncbiprotein/3972> .

<http://rdf.wikipathways.org/Pathway/WP4194_r142017/WP/Interaction/id46b63bd4>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4194_r142017> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4194_r142017/Interaction/id46b63bd4> ;
        wp:participants   <https://identifiers.org/ncbigene/2691> , <https://identifiers.org/chebi/CHEBI:50114> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:50114> ;
        wp:target         <https://identifiers.org/ncbigene/2691> .

<https://identifiers.org/pubmed/12955018>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "12955018" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4194_r142017> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/12955018> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4194&oldid=142017>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .
