@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ncbigene/25331>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Mat1a" ;
        dc:identifier       <https://identifiers.org/ncbigene/25331> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "25331" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000011351> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/25331> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F1LZ34> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a0b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F1LZ34> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/25331> .

<https://identifiers.org/ncbigene/89833>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Ftcd" ;
        dc:identifier       <https://identifiers.org/ncbigene/89833> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "89833" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e36> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ad22d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e26c9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000001261> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/89833> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O88618> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d37> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c5a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O88618> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/89833> .

<https://identifiers.org/chebi/CHEBI:17015>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "vitamin B2" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/AUNGANRZJHBGPY-SCRDCRAPSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:17015> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:17015" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17015> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/431981> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000244> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/AUNGANRZJHBGPY-SCRDCRAPSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00255> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID493570> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q130365> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/f13> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17015> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/da294>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/da294> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/abd23> ;
        wp:participants   <https://identifiers.org/ncbigene/64300> , <https://identifiers.org/chebi/CHEBI:12071> , <https://identifiers.org/cas/7444-29-3> ;
        wp:source         <https://identifiers.org/ncbigene/64300> , <https://identifiers.org/cas/7444-29-3> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:12071> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/cc64f>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/e5b6f> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/cc64f> ;
        wp:participants   <https://identifiers.org/cas/4033-27-6> , <https://identifiers.org/ncbigene/24312> , <https://identifiers.org/cas/59-30-3> ;
        wp:source         <https://identifiers.org/ncbigene/24312> , <https://identifiers.org/cas/59-30-3> ;
        wp:target         <https://identifiers.org/cas/4033-27-6> .

<https://identifiers.org/ncbigene/64392>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ALDH1L1" ;
        dc:identifier       <https://identifiers.org/ncbigene/64392> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "64392" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000047023> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/64392> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/M0R8T2> , <https://identifiers.org/uniprot/A0A8I6GG93> , <https://identifiers.org/uniprot/A0A0G2K0D8> , <https://identifiers.org/uniprot/P28037> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/cb2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I6GG93> , <http://purl.uniprot.org/uniprot/A0A0G2K0D8> , <http://purl.uniprot.org/uniprot/P28037> , <http://purl.uniprot.org/uniprot/M0R8T2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/64392> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/af47c>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/af47c> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/f4991> ;
        wp:participants   <https://identifiers.org/ncbigene/64365> , <https://identifiers.org/chemspider/21403073> , <https://identifiers.org/chemspider/24921423> ;
        wp:source         <https://identifiers.org/chemspider/24921423> , <https://identifiers.org/ncbigene/64365> ;
        wp:target         <https://identifiers.org/chemspider/21403073> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/a18c0>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/a18c0> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/f6828> ;
        wp:participants   <https://identifiers.org/ncbigene/362657> , <https://identifiers.org/chebi/CHEBI:12071> , <https://identifiers.org/cas/134-35-0> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:12071> , <https://identifiers.org/ncbigene/362657> ;
        wp:target         <https://identifiers.org/cas/134-35-0> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e79>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/cd618> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c9e79> ;
        wp:participants   <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/cas/134-35-0> ;
        wp:source         <https://identifiers.org/cas/134-35-0> ;
        wp:target         <https://identifiers.org/cas/135-16-0> .

<https://identifiers.org/cas/107-43-7>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Betaine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/KWIUHFFTVRNATP-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/cas/107-43-7> ;
        dc:source           "CAS" ;
        dcterms:identifier  "107-43-7" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b555e> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17750> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/242> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/KWIUHFFTVRNATP-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00719> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID247> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q10860583> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/aeb> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=107-43-7> .

<https://identifiers.org/cas/25513-46-6>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Polyglutamate" ;
        dc:identifier       <https://identifiers.org/cas/25513-46-6> ;
        dc:source           "CAS" ;
        dcterms:identifier  "25513-46-6" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ac4c5> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:53374> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q26995368> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/fed> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=25513-46-6> .

<https://identifiers.org/ncbigene/444985>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Dnmt3b" ;
        dc:identifier       <https://identifiers.org/ncbigene/444985> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "444985" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000010625> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/444985> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0G2JYR2> , <https://identifiers.org/uniprot/A0A8I6AVL3> , <https://identifiers.org/uniprot/A0A8J8XG14> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c78> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0G2JYR2> , <http://purl.uniprot.org/uniprot/A0A8J8XG14> , <http://purl.uniprot.org/uniprot/A0A8I6AVL3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/444985> .

<https://identifiers.org/cas/59-30-3>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Monoglutamate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/OVBPIULPVIDEAO-LBPRGKRZSA-N> ;
        dc:identifier       <https://identifiers.org/cas/59-30-3> ;
        dc:source           "CAS" ;
        dcterms:identifier  "59-30-3" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ac4c5> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c71ae> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/cc64f> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:27470> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5815> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000121> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/OVBPIULPVIDEAO-LBPRGKRZSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00504> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135398658> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6037> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q127060> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/ccf> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=59-30-3> .

<https://identifiers.org/chemspider/315142>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Deoxythymidine monophosphate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/WVNRRNJFRREKAR-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/315142> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "315142" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f0d65> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/315142> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0250899> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/WVNRRNJFRREKAR-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID355024> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q42403291> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c8c> ;
        foaf:page           <https://www.chemspider.com/315142> .

<https://identifiers.org/ncbigene/315763>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mtfmt" ;
        dc:identifier       <https://identifiers.org/ncbigene/315763> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "315763" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/315763> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/b1b> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/315763> .

<https://identifiers.org/ncbigene/300886>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mthfs" ;
        dc:identifier       <https://identifiers.org/ncbigene/300886> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "300886" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b27c7> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/300886> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a74> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/300886> .

<https://identifiers.org/ncbigene/689330>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mat2b" ;
        dc:identifier       <https://identifiers.org/ncbigene/689330> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "689330" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/689330> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d10> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/689330> .

<https://identifiers.org/ncbigene/362657>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Mthfr" ;
        dc:identifier       <https://identifiers.org/ncbigene/362657> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "362657" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/a18c0> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000008553> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/362657> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I6A5Q6> , <https://identifiers.org/uniprot/A0A8I6A4C5> , <https://identifiers.org/uniprot/D4A7E8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c0a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I6A4C5> , <http://purl.uniprot.org/uniprot/D4A7E8> , <http://purl.uniprot.org/uniprot/A0A8I6A5Q6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/362657> .

<https://identifiers.org/cas/29908-03-0>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "S-Adenosylmethionine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MEFKEPWMEQBLKI-AIRLBKTGSA-N> ;
        dc:identifier       <https://identifiers.org/cas/29908-03-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "29908-03-0" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fb18d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/aeb0d> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:67040> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/31982> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MEFKEPWMEQBLKI-AIRLBKTGSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00019> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID34755> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27135598> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/dd1> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=29908-03-0> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fd2f4>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/bcc27> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/fd2f4> ;
        wp:participants   <https://identifiers.org/cas/6027-13-0> , <https://identifiers.org/cas/979-92-0> ;
        wp:source         <https://identifiers.org/cas/979-92-0> ;
        wp:target         <https://identifiers.org/cas/6027-13-0> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/cb47d>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/cb47d> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:30879> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ac4c5> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:30879> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ac4c5> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fb535>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/aa565> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/fb535> ;
        wp:participants   <https://identifiers.org/cas/7444-29-3> , <https://identifiers.org/cas/2800-34-2> ;
        wp:source         <https://identifiers.org/cas/2800-34-2> ;
        wp:target         <https://identifiers.org/cas/7444-29-3> .

<https://identifiers.org/ncbigene/29261>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Tyms" ;
        dc:identifier       <https://identifiers.org/ncbigene/29261> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "29261" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f0d65> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e11c5> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/29261> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/df4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/29261> .

<https://identifiers.org/chemspider/24921423>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Cobalamin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/RMRCNWBMXRMIRW-WZHZPDAFSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/24921423> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "24921423" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/dcdb7> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/af47c> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17439> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/24921423> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/RMRCNWBMXRMIRW-WZHZPDAFSA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID166596686> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a603d> ;
        foaf:page           <https://www.chemspider.com/24921423> .

<https://identifiers.org/cas/134-35-0>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "5-Methyl Tetrahydrofolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZNOVTXRBGFNYRX-ZGTCLIOFSA-N> , <https://identifiers.org/inchikey/ZNOVTXRBGFNYRX-ABLWVSNPSA-N> ;
        dc:identifier       <https://identifiers.org/cas/134-35-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "134-35-0" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/a18c0> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e79> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15641> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388371> , <https://identifiers.org/chemspider/8001181> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001396> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ZNOVTXRBGFNYRX-ABLWVSNPSA-N> , <https://identifiers.org/inchikey/ZNOVTXRBGFNYRX-ZGTCLIOFSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00440> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135415868> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9825434> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439234> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27290485> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a42> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=134-35-0> .

<https://identifiers.org/ncbigene/444984>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Dnmt3a" ;
        dc:identifier       <https://identifiers.org/ncbigene/444984> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "444984" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000026649> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/444984> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q1LZ53> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/eb3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q1LZ53> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/444984> .

<https://identifiers.org/chebi/CHEBI:27306>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "vitamin B6" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:27306> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:27306" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:27306> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q205130> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/e73> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27306> .

<https://identifiers.org/ncbigene/361472>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mthfd1l" ;
        dc:identifier       <https://identifiers.org/ncbigene/361472> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "361472" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000019582> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/361472> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B2GUZ3> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c1d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/aa1> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/e94> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/B2GUZ3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/361472> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b555e>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/b555e> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c29b8> ;
        wp:participants   <https://identifiers.org/cas/6027-13-0> , <https://identifiers.org/ncbigene/81508> , <https://identifiers.org/cas/107-43-7> ;
        wp:source         <https://identifiers.org/cas/107-43-7> , <https://identifiers.org/ncbigene/81508> ;
        wp:target         <https://identifiers.org/cas/6027-13-0> .

<https://identifiers.org/ncbigene/299857>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Shmt2" ;
        dc:identifier       <https://identifiers.org/ncbigene/299857> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "299857" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/299857> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/e55> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/299857> .

<https://identifiers.org/cas/4033-27-6>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Dihydrofolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/OZRNSSUDZOLUSN-LBPRGKRZSA-N> ;
        dc:identifier       <https://identifiers.org/cas/4033-27-6> ;
        dc:source           "CAS" ;
        dcterms:identifier  "4033-27-6" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5f7d> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/cc64f> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e11c5> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15633> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/89228> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001056> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/OZRNSSUDZOLUSN-LBPRGKRZSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00415> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135398604> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID98792> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q192367> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d00> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=4033-27-6> .

<https://identifiers.org/ncbigene/84350>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Dnmt1" ;
        dc:identifier       <https://identifiers.org/ncbigene/84350> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "84350" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/84350> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/b3b> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/84350> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c71ae>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/b2d32> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c71ae> ;
        wp:participants   <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/cas/59-30-3> , <https://identifiers.org/ncbigene/24312> ;
        wp:source         <https://identifiers.org/cas/59-30-3> , <https://identifiers.org/ncbigene/24312> ;
        wp:target         <https://identifiers.org/cas/135-16-0> .

<https://identifiers.org/cas/7444-29-3>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "5,10-Methenyl Tetrahydrofolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MEANFMOQMXYMCT-OLZOCXBDSA-N> ;
        dc:identifier       <https://identifiers.org/cas/7444-29-3> ;
        dc:source           "CAS" ;
        dcterms:identifier  "7444-29-3" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/da294> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e36> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fb535> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b27c7> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e53e6> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5e46> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15636> , <https://identifiers.org/chebi/CHEBI:15638> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/559356> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001354> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MEANFMOQMXYMCT-OLZOCXBDSA-N> , <https://identifiers.org/inchikey/MEANFMOQMXYMCT-OLZOCXBDSA-O> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00445> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135450599> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID137250216> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135405047> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q2823228> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c07> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=7444-29-3> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5e46>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c6029> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c5e46> ;
        wp:participants   <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/cas/7444-29-3> , <https://identifiers.org/ncbigene/288259> ;
        wp:source         <https://identifiers.org/cas/7444-29-3> , <https://identifiers.org/ncbigene/288259> ;
        wp:target         <https://identifiers.org/cas/135-16-0> .

<https://identifiers.org/wikipathways/WP1292_r138043>
        rdf:type               wp:Pathway , skos:Collection ;
        dc:identifier          <https://identifiers.org/wikipathways/WP1292> ;
        dc:source              "WikiPathways" ;
        dc:title               "One-carbon metabolism"@en ;
        dcterms:description    "This one-carbon metabolism pathway is centered around folate. Folate has two key carbon-carbon double bonds. Saturating one of them yields dihydrofolate (DHF) and adding an additional molecule of hydrogen across the second yields tetrahydrofolate (THF). Folates serve as donors of single carbons in any one of three oxidation states: 5-methyl-THF (CH3THF; reduced), 5,10 methylene-THF (CH2THF; intermediate) and 10-formyl-THF (CHOTHF; oxidized). The single carbon donor CH3THF is used to convert homocysteine into methionine which can then be used to methylate DNA, the donor CH2THF is used (along with a molecule of hydrogen at the site of one of the double bonds) to convert dUMP (deoxyuridylate) into dTMP (thymidylate) and the donor CHOTHF is used to set up ring closure reactions in de novo purine synthesis. CH3THF is the primary methyl-group donor for processes such as DNA methylation reactions. Purines are used both in RNA synthesis and in DNA synthesis and dTMP is synthesized srtictly for DNA synthesis, be it for DNA repair or DNA replication.\nThe folate pathway is central to any study related to DNA methylation, dTMP synthesis or purine synthesis.\n\nDifferential methylation (e.g. hypermethylation of tumor suppressors) as well as disturbances in nucleotide synthesis and repair, are associated with several forms of cancer. There are also indications that hypermethylation is involved in the progression of adenomas to cancer.  " ;
        dcterms:identifier     "WP1292" ;
        cito:cites             <https://identifiers.org/pubmed/17389618> ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP1292_r138043> ;
        wp:ontologyTag         obo:PW_0000189 , wp:Curation:AnalysisCollection , wp:Curation:Micronutrients , wp:Curation:Homology_Converted ;
        wp:organism            obo:NCBITaxon_10116 ;
        wp:organismName        "Rattus norvegicus" ;
        wp:pathwayOntologyTag  obo:PW_0000189 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1292&oldid=138043> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1292&oldid=138043> ;
        foaf:page              <http://www.wikipathways.org/instance/WP1292_r138043> .

<https://identifiers.org/cas/135-16-0>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Tetrahydrofolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MSTNYGQPCMXVAQ-KIYNQFGBSA-N> , <https://identifiers.org/inchikey/MSTNYGQPCMXVAQ-PXYINDEMSA-N> ;
        dc:identifier       <https://identifiers.org/cas/135-16-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "135-16-0" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e26c9> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5f7d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e002d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c71ae> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5e46> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/af59a> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e79> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ad22d> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:20506> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/82572> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304496> , <https://identifiers.org/hmdb/HMDB0001846> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MSTNYGQPCMXVAQ-PXYINDEMSA-N> , <https://identifiers.org/inchikey/MSTNYGQPCMXVAQ-KIYNQFGBSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00101> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID91443> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135444742> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q53668656> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a19> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=135-16-0> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e36>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/fd2d2> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c9e36> ;
        wp:participants   <https://identifiers.org/ncbigene/89833> , <https://identifiers.org/cas/7444-29-3> , <https://identifiers.org/chebi/CHEBI:15639> ;
        wp:source         <https://identifiers.org/ncbigene/89833> , <https://identifiers.org/chebi/CHEBI:15639> ;
        wp:target         <https://identifiers.org/cas/7444-29-3> .

<https://identifiers.org/chebi/CHEBI:15639>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "5-Formimino Tetrahydrafolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/YCWUVLPMLLBDCU-STQMWFEESA-N> , <https://identifiers.org/inchikey/YCWUVLPMLLBDCU-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15639> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:15639" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c9e36> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ad22d> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15639> ;
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        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135398659> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID530> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5459780> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/f6f> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15639> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ad22d>
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        wp:source         <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/ncbigene/89833> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:15639> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1292&oldid=138043>
        rdf:type        foaf:Image ;
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<https://identifiers.org/chemspider/21403073>
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        rdfs:label          "Methyl-cobalamin" ;
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        dc:identifier       <https://identifiers.org/chemspider/21403073> ;
        dc:source           "Chemspider" ;
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        wp:bdbChemspider    <https://identifiers.org/chemspider/21403073> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/UKAOQJHGJIMJQJ-WZHZPDAFSA-L> ;
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        foaf:page           <https://www.chemspider.com/21403073> .

<https://identifiers.org/ncbigene/288259>
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        rdfs:label          "Gart" ;
        dc:identifier       <https://identifiers.org/ncbigene/288259> ;
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        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V918> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/288259> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/af59a>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
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        wp:participants   <https://identifiers.org/cas/2800-34-2> , <https://identifiers.org/cas/135-16-0> ;
        wp:source         <https://identifiers.org/cas/135-16-0> ;
        wp:target         <https://identifiers.org/cas/2800-34-2> .

<https://identifiers.org/ncbigene/312192>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Ahcyl2" ;
        dc:identifier       <https://identifiers.org/ncbigene/312192> ;
        dc:source           "Entrez Gene" ;
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        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000039300> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/312192> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D3ZWL6> , <https://identifiers.org/uniprot/A0A8I6ABA9> , <https://identifiers.org/uniprot/A0A8I5ZKU2> , <https://identifiers.org/uniprot/A0A8I6A7Z2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/ca3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I6A7Z2> , <http://purl.uniprot.org/uniprot/A0A8I6ABA9> , <http://purl.uniprot.org/uniprot/D3ZWL6> , <http://purl.uniprot.org/uniprot/A0A8I5ZKU2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/312192> .

<https://identifiers.org/ncbigene/64300>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Mthfd1" ;
        dc:identifier       <https://identifiers.org/ncbigene/64300> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "64300" ;
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        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/64300> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/e02> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a92> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/ba6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/64300> .

<https://identifiers.org/ncbigene/81508>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Bhmt" ;
        dc:identifier       <https://identifiers.org/ncbigene/81508> ;
        dc:source           "Entrez Gene" ;
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        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000011200> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/81508> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0G2JSK9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a0c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0G2JSK9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/81508> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e11c5>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/a7eff> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/e11c5> ;
        wp:participants   <https://identifiers.org/cas/4033-27-6> , <https://identifiers.org/ncbigene/29261> , <https://identifiers.org/chebi/CHEBI:12071> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:12071> , <https://identifiers.org/ncbigene/29261> ;
        wp:target         <https://identifiers.org/cas/4033-27-6> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e26c9>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/d326e> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/e26c9> ;
        wp:participants   <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/ncbigene/89833> , <https://identifiers.org/chebi/CHEBI:57457> ;
        wp:source         <https://identifiers.org/ncbigene/89833> , <https://identifiers.org/cas/135-16-0> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:57457> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/aeb0d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/ce6b4> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/aeb0d> ;
        wp:participants   <https://identifiers.org/cas/29908-03-0> , <https://identifiers.org/cas/63-68-3> ;
        wp:source         <https://identifiers.org/cas/63-68-3> ;
        wp:target         <https://identifiers.org/cas/29908-03-0> .

<https://identifiers.org/ncbigene/81643>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Atic" ;
        dc:identifier       <https://identifiers.org/ncbigene/81643> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "81643" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/81643> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/ef6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/81643> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ac4c5>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/ac4c5> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/e3b76> ;
        wp:participants   <https://identifiers.org/cas/59-30-3> , <https://identifiers.org/cas/25513-46-6> , <https://identifiers.org/ncbigene/85309> ;
        wp:source         <https://identifiers.org/cas/25513-46-6> , <https://identifiers.org/ncbigene/85309> ;
        wp:target         <https://identifiers.org/cas/59-30-3> .

<https://identifiers.org/ncbigene/306586>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Amt" ;
        dc:identifier       <https://identifiers.org/ncbigene/306586> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "306586" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e53e6> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/306586> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d76> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/cc5> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/306586> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e002d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/d9ac0> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/e002d> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:12071> , <https://identifiers.org/cas/135-16-0> ;
        wp:source         <https://identifiers.org/cas/135-16-0> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:12071> .

<https://identifiers.org/chebi/CHEBI:12071>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "5,10-Methylene Tetrahydrofolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/QYNUQALWYRSVHF-ABLWVSNPSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:12071> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:12071" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e11c5> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e002d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/da294> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/a18c0> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:12071> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/10140306> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/QYNUQALWYRSVHF-ABLWVSNPSA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11966313> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135510647> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27108922> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d13> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:12071> .

<https://identifiers.org/cas/63-68-3>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Methionine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FFEARJCKVFRZRR-BYPYZUCNSA-N> ;
        dc:identifier       <https://identifiers.org/cas/63-68-3> ;
        dc:source           "CAS" ;
        dcterms:identifier  "63-68-3" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/aeb0d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f9d95> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16643> , <https://identifiers.org/chebi/CHEBI:57844> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5907> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000696> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/FFEARJCKVFRZRR-BYPYZUCNSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00073> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6992087> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6137> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q106345486> , <http://www.wikidata.org/entity/Q22124685> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d31> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=63-68-3> .

<https://identifiers.org/cas/2800-34-2>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "10-Formyl Tetrahydrofolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/AUFGTPPARQZWDO-YUZLPWPTSA-N> ;
        dc:identifier       <https://identifiers.org/cas/2800-34-2> ;
        dc:source           "CAS" ;
        dcterms:identifier  "2800-34-2" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fb535> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/af59a> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15637> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/109092> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000972> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/AUFGTPPARQZWDO-YUZLPWPTSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00234> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID122347> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135450591> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q47459238> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c01> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=2800-34-2> .

<https://identifiers.org/cas/979-92-0>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "S-adenosylhomocysteine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZJUKTBDSGOFHSH-WFMPWKQPSA-N> ;
        dc:identifier       <https://identifiers.org/cas/979-92-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "979-92-0" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fb18d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fd2f4> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:57856> , <https://identifiers.org/chebi/CHEBI:16680> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388301> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000939> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ZJUKTBDSGOFHSH-WFMPWKQPSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00021> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID25246222> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439155> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q307434> , <http://www.wikidata.org/entity/Q106345616> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d97> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=979-92-0> .

<https://identifiers.org/ncbigene/287379>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Shmt1" ;
        dc:identifier       <https://identifiers.org/ncbigene/287379> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "287379" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000005275> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/287379> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q6TXG7> , <https://identifiers.org/uniprot/A0A8I5ZKU9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/d3d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q6TXG7> , <http://purl.uniprot.org/uniprot/A0A8I5ZKU9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/287379> .

<https://identifiers.org/ncbigene/81522>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mtr" ;
        dc:identifier       <https://identifiers.org/ncbigene/81522> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "81522" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000017593> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/81522> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V8A4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/c04> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V8A4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/81522> .

<https://identifiers.org/wikipathways/WP1292>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP1292_r138043> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1292&oldid=138043>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/ncbigene/290947>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Mtrr" ;
        dc:identifier       <https://identifiers.org/ncbigene/290947> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "290947" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000017826> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/290947> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q498R1> , <https://identifiers.org/uniprot/A0A8L2QCU1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/ccb> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q498R1> , <http://purl.uniprot.org/uniprot/A0A8L2QCU1> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/290947> .

<https://identifiers.org/ncbigene/29443>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Ahcy" ;
        dc:identifier       <https://identifiers.org/ncbigene/29443> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "29443" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000017777> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/29443> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5ZM95> , <https://identifiers.org/uniprot/P10760> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/fa9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5ZM95> , <http://purl.uniprot.org/uniprot/P10760> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/29443> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c10cf>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c10cf> ;
        wp:participants   <https://identifiers.org/chemspider/5736> , <https://identifiers.org/chemspider/730> ;
        wp:source         <https://identifiers.org/chemspider/730> ;
        wp:target         <https://identifiers.org/chemspider/5736> .

<https://identifiers.org/chemspider/730>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Glycine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/DHMQDGOQFOQNFH-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/730> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "730" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c10cf> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:57305> , <https://identifiers.org/chebi/CHEBI:15428> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/730> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000123> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/DHMQDGOQFOQNFH-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00037> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5257127> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID750> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q620730> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/ff7> ;
        foaf:page           <https://www.chemspider.com/730> .

<https://identifiers.org/chebi/CHEBI:57457>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "5-Formyl Tetrahydrafolate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/VVIAGPKUTFNRDU-STQMWFEESA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:57457> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:57457" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b27c7> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e26c9> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e53e6> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:57457> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5028014> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/VVIAGPKUTFNRDU-STQMWFEESA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135398558> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6560146> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27124703> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a00> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57457> .

<https://identifiers.org/ncbigene/680308>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Mthfd2" ;
        dc:identifier       <https://identifiers.org/ncbigene/680308> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "680308" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000010833> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/680308> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I6GID3> , <https://identifiers.org/uniprot/D4A1Y5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/f83> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a7b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I6GID3> , <http://purl.uniprot.org/uniprot/D4A1Y5> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/680308> .

<https://identifiers.org/chebi/CHEBI:27551>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "DNA 5-methylcytosine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/LRSASMSXMSNRBT-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:27551> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:27551" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:27551> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/58551> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0002894> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/LRSASMSXMSNRBT-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C02376> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID65040> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q238563> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a84> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27551> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b27c7>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c9336> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/b27c7> ;
        wp:participants   <https://identifiers.org/cas/7444-29-3> , <https://identifiers.org/ncbigene/300886> , <https://identifiers.org/chebi/CHEBI:57457> ;
        wp:source         <https://identifiers.org/ncbigene/300886> , <https://identifiers.org/chebi/CHEBI:57457> ;
        wp:target         <https://identifiers.org/cas/7444-29-3> .

<https://identifiers.org/pubmed/17389618>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "17389618" ;
        dcterms:isPartOf    <https://identifiers.org/cas/63-68-3> , <https://identifiers.org/cas/134-35-0> , <https://identifiers.org/ncbigene/81522> , <https://identifiers.org/ncbigene/81643> , <https://identifiers.org/ncbigene/84350> , <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/chebi/CHEBI:12071> , <https://identifiers.org/cas/107-43-7> , <https://identifiers.org/ncbigene/287379> , <https://identifiers.org/ncbigene/64365> , <https://identifiers.org/ncbigene/64392> , <https://identifiers.org/cas/6027-13-0> , <https://identifiers.org/cas/59-30-3> , <https://identifiers.org/cas/2800-34-2> , <https://identifiers.org/ncbigene/64300> , <https://identifiers.org/ncbigene/288259> , <https://identifiers.org/cas/979-92-0> , <https://identifiers.org/ncbigene/362657> , <https://identifiers.org/ncbigene/85309> , <https://identifiers.org/ncbigene/81508> , <https://identifiers.org/cas/25513-46-6> , <https://identifiers.org/cas/29908-03-0> , <https://identifiers.org/cas/4033-27-6> , <https://identifiers.org/ncbigene/290947> , <https://identifiers.org/cas/7444-29-3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17389618> .

<https://identifiers.org/ncbigene/24312>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Dhfr" ;
        dc:identifier       <https://identifiers.org/ncbigene/24312> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "24312" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/cc64f> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5f7d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c71ae> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000013521> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/24312> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B0BMV8> , <https://identifiers.org/uniprot/Q920D2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a74c2> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/fe0c8> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/fea> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/B0BMV8> , <http://purl.uniprot.org/uniprot/Q920D2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/24312> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fb18d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/bedc2> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/fb18d> ;
        wp:participants   <https://identifiers.org/cas/979-92-0> , <https://identifiers.org/cas/29908-03-0> ;
        wp:source         <https://identifiers.org/cas/29908-03-0> ;
        wp:target         <https://identifiers.org/cas/979-92-0> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f9d95>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/a49b1> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/f9d95> ;
        wp:participants   <https://identifiers.org/cas/63-68-3> , <https://identifiers.org/cas/6027-13-0> ;
        wp:source         <https://identifiers.org/cas/6027-13-0> ;
        wp:target         <https://identifiers.org/cas/63-68-3> .

<https://identifiers.org/ncbigene/64365>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Tcn2" ;
        dc:identifier       <https://identifiers.org/ncbigene/64365> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "64365" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/dcdb7> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/af47c> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000004280> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/64365> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V6K1> , <https://identifiers.org/uniprot/A0A8I5YCJ2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/fc6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5YCJ2> , <http://purl.uniprot.org/uniprot/G3V6K1> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/64365> .

<https://identifiers.org/chebi/CHEBI:17622>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Deoxyuridine monophosphate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/JSRLJPSBLDHEIO-SHYZEUOFSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:17622> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:17622" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f0d65> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17622> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/58574> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001409> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/JSRLJPSBLDHEIO-SHYZEUOFSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00365> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID65063> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q2741362> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/a47> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17622> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/e53e6>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c77aa> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/e53e6> ;
        wp:participants   <https://identifiers.org/cas/7444-29-3> , <https://identifiers.org/chebi/CHEBI:57457> , <https://identifiers.org/ncbigene/306586> ;
        wp:source         <https://identifiers.org/ncbigene/306586> , <https://identifiers.org/cas/7444-29-3> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:57457> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c5f7d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/c5f7d> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/d681f> ;
        wp:participants   <https://identifiers.org/cas/135-16-0> , <https://identifiers.org/ncbigene/24312> , <https://identifiers.org/cas/4033-27-6> ;
        wp:source         <https://identifiers.org/cas/4033-27-6> , <https://identifiers.org/ncbigene/24312> ;
        wp:target         <https://identifiers.org/cas/135-16-0> .

obo:NCBITaxon_10116  obo:NCIT_C179773  "10116" .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/dcdb7>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/df4c3> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/dcdb7> ;
        wp:participants   <https://identifiers.org/chemspider/21403073> , <https://identifiers.org/chemspider/24921423> , <https://identifiers.org/ncbigene/64365> ;
        wp:source         <https://identifiers.org/chemspider/24921423> , <https://identifiers.org/ncbigene/64365> ;
        wp:target         <https://identifiers.org/chemspider/21403073> .

<https://identifiers.org/ncbigene/85309>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FOLH1" ;
        dc:identifier       <https://identifiers.org/ncbigene/85309> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "85309" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/ac4c5> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSRNOG00000013770> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/85309> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V7S0> , <https://identifiers.org/uniprot/A0A8I6ABM7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/adf> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I6ABM7> , <http://purl.uniprot.org/uniprot/G3V7S0> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/85309> .

<http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f0d65>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/f0d65> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/Interaction/a316f> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:17622> , <https://identifiers.org/ncbigene/29261> , <https://identifiers.org/chemspider/315142> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:17622> , <https://identifiers.org/ncbigene/29261> ;
        wp:target         <https://identifiers.org/chemspider/315142> .

<https://identifiers.org/chemspider/5736>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Serine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MTCFGRXMJLQNBG-REOHCLBHSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/5736> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "5736" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/c10cf> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17115> , <https://identifiers.org/chebi/CHEBI:33384> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5736> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000187> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MTCFGRXMJLQNBG-REOHCLBHSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00065> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6857581> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5951> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q183290> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/b93> ;
        foaf:page           <https://www.chemspider.com/5736> .

<https://identifiers.org/cas/6027-13-0>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Homocysteine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FFFHZYDWPBMWHY-VKHMYHEASA-N> ;
        dc:identifier       <https://identifiers.org/cas/6027-13-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "6027-13-0" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/fd2f4> , <https://identifiers.org/wikipathways/WP1292_r138043> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/f9d95> , <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/b555e> ;
        dcterms:references  <https://identifiers.org/pubmed/17389618> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:58199> , <https://identifiers.org/chebi/CHEBI:17588> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/82666> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000742> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/FFFHZYDWPBMWHY-VKHMYHEASA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00155> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID91552> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6971015> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q26992833> , <http://www.wikidata.org/entity/Q106345493> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/f77> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=6027-13-0> .

<https://identifiers.org/chebi/CHEBI:30879>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "alcohol" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:30879> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:30879" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1292_r138043/WP/Interaction/cb47d> , <https://identifiers.org/wikipathways/WP1292_r138043> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:30879> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q156> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1292_r138043/DataNode/e0300> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30879> .
