@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/chebi/CHEBI:18035>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "DAG" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:18035> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:18035" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/ide0f0dcf0> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id1abd0d9f> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id9f53f011> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00165> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMGL0201> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q161466> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/a767c> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMGL0201> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18035> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id9f53f011>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id9f53f011> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:18035> , <https://identifiers.org/ensembl/ENSG00000182621> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000182621> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:18035> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/idbe4fea9a>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/idbe4fea9a> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000118432> , <https://identifiers.org/chebi/CHEBI:67197> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:67197> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000118432> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id9a8ecce4>
        rdf:type            wp:DirectedInteraction , wp:Interaction , wp:Inhibition ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        dcterms:references  <https://identifiers.org/pubmed/21173082> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id9a8ecce4> ;
        wp:participants     <https://identifiers.org/ensembl/ENSG00000118432> , <https://identifiers.org/chemspider/116> ;
        wp:source           <https://identifiers.org/ensembl/ENSG00000118432> ;
        wp:target           <https://identifiers.org/chemspider/116> .

<https://identifiers.org/ensembl/ENSG00000134780>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "DAG lipase" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000134780> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000134780" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/ide0f0dcf0> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000134780> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/747> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DAGLA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9Y4D2> , <https://identifiers.org/uniprot/F5GY58> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17854281> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/d8ae1> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F5GY58> , <http://purl.uniprot.org/uniprot/Q9Y4D2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000134780> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/ida36b9784>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/ida36b9784> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000110148> , <https://identifiers.org/pubchem.compound/122130> ;
        wp:source         <https://identifiers.org/pubchem.compound/122130> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000110148> .

<https://identifiers.org/chemspider/4209>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "NEM" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/HDFGOPSGAURCEO-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/4209> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "4209" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:44485> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4209> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0255137> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/HDFGOPSGAURCEO-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C02441> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID4362> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q292393> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/c7e6a> ;
        foaf:page           <https://www.chemspider.com/4209> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/ida4f5458d>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/ida4f5458d> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:29108> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id65c80b61>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id65c80b61> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000182621> , <https://identifiers.org/ensembl/ENSG00000156052> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000156052> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000182621> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/iddda8a114>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/iddda8a114> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:67197> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:67197> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:67197> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id9071c85b>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id9071c85b> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:29108> .

<https://identifiers.org/ensembl/ENSG00000156052>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Gq" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000156052> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000156052" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id65c80b61> , <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Complex/bcc43> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000156052> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2776> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GNAQ> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B1AM21> , <https://identifiers.org/uniprot/A0A024R240> , <https://identifiers.org/uniprot/P50148> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18026236> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/b1304> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P50148> , <http://purl.uniprot.org/uniprot/A0A024R240> , <http://purl.uniprot.org/uniprot/B1AM21> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000156052> .

<https://identifiers.org/pubmed/21795548>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "21795548" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/21795548> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/Complex/f4f1f>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Group/f4f1f> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000110148> , <https://identifiers.org/ensembl/ENSG00000127955> .

<https://identifiers.org/ensembl/ENSG00000198626>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RYR2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198626> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198626" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198626> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6262> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RYR2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q92736> , <https://identifiers.org/uniprot/A0A590UKB7> , <https://identifiers.org/uniprot/A0A590UK06> , <https://identifiers.org/uniprot/A0A590UJF6> , <https://identifiers.org/uniprot/A0A590UJZ8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031341> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/d7e98> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/f5bd2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q92736> , <http://purl.uniprot.org/uniprot/A0A590UJZ8> , <http://purl.uniprot.org/uniprot/A0A590UKB7> , <http://purl.uniprot.org/uniprot/A0A590UJF6> , <http://purl.uniprot.org/uniprot/A0A590UK06> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198626> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id1abd0d9f>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id1abd0d9f> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:67197> , <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:67197> .

<https://identifiers.org/ensembl/ENSG00000127955>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Gi/0" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000127955> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000127955" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Complex/f4f1f> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000127955> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2770> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GNAI1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A3B3ITM0> , <https://identifiers.org/uniprot/A0A3B3ITG4> , <https://identifiers.org/uniprot/P63096> , <https://identifiers.org/uniprot/A0A3B3IS42> , <https://identifiers.org/uniprot/A0A3B3IU77> , <https://identifiers.org/uniprot/A0A3B3IUA8> , <https://identifiers.org/uniprot/A0A3B3ITX3> , <https://identifiers.org/uniprot/A0A3B3IRK0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18026220> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/b0440> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A3B3IRK0> , <http://purl.uniprot.org/uniprot/A0A3B3IUA8> , <http://purl.uniprot.org/uniprot/A0A3B3IU77> , <http://purl.uniprot.org/uniprot/A0A3B3ITX3> , <http://purl.uniprot.org/uniprot/A0A3B3ITG4> , <http://purl.uniprot.org/uniprot/A0A3B3ITM0> , <http://purl.uniprot.org/uniprot/A0A3B3IS42> , <http://purl.uniprot.org/uniprot/P63096> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000127955> .

<https://identifiers.org/pubchem.compound/123847>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "cyclic ADPR" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BQOHYSXSASDCEA-KEOHHSTQSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/123847> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "123847" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:31445> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/21403087> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BQOHYSXSASDCEA-KEOHHSTQSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C13050> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID123847> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q2467043> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/aaded> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=123847> .

<https://identifiers.org/chemspider/16736002>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ryanodine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/JJSYXNQGLHBRRK-SFEDZAPPSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/16736002> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "16736002" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:8925> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/16736002> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/JJSYXNQGLHBRRK-SFEDZAPPSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11317883> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q59851226> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/dcf80> ;
        foaf:page           <https://www.chemspider.com/16736002> .

<https://identifiers.org/pubchem.compound/122130>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "YM022" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/YCXFHPUBGMMWJQ-PMERELPUSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/122130> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "122130" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/ida36b9784> , <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/idf65f9f23> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/108930> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/YCXFHPUBGMMWJQ-PMERELPUSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID122130> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27089258> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/fd188> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/a8817> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=122130> .

<https://identifiers.org/ensembl/ENSG00000198838>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RYR3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198838> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198838" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198838> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6263> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RYR3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A1B0GTT7> , <https://identifiers.org/uniprot/Q15413> , <https://identifiers.org/uniprot/A0A1B0GTF2> , <https://identifiers.org/uniprot/A0A1B0GUB0> , <https://identifiers.org/uniprot/A0A1B0GVA9> , <https://identifiers.org/uniprot/A0A0X1KG73> , <https://identifiers.org/uniprot/A0A0U1RRH1> , <https://identifiers.org/uniprot/A0A1B0GU27> , <https://identifiers.org/uniprot/A0A1B0GVS2> , <https://identifiers.org/uniprot/A0A0U1RR54> , <https://identifiers.org/uniprot/A0A0U1RR21> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031342> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/ddb48> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/a3822> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A1B0GVS2> , <http://purl.uniprot.org/uniprot/A0A0X1KG73> , <http://purl.uniprot.org/uniprot/Q15413> , <http://purl.uniprot.org/uniprot/A0A0U1RRH1> , <http://purl.uniprot.org/uniprot/A0A1B0GUB0> , <http://purl.uniprot.org/uniprot/A0A0U1RR54> , <http://purl.uniprot.org/uniprot/A0A1B0GTF2> , <http://purl.uniprot.org/uniprot/A0A1B0GU27> , <http://purl.uniprot.org/uniprot/A0A0U1RR21> , <http://purl.uniprot.org/uniprot/A0A1B0GVA9> , <http://purl.uniprot.org/uniprot/A0A1B0GTT7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198838> .

<https://identifiers.org/pubchem.compound/3081323>
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        rdfs:label          "8-NH2-cADPR" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/WZEWLTIOWBOCDF-XWPVMSEFSA-N> ;
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        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3081323> .

<https://identifiers.org/wikipathways/WP3679_r140517>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP3679> ;
        dc:source               "WikiPathways" ;
        dc:title                "Cell-type dependent selectivity of CCK2R signaling"@en ;
        dcterms:description     "This pathway is based on Figure 7 of \"Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal Parvalbumin-Positive Fast-Spiking Basket Cells.\"(See Bibliography).The neuropeptide cholecystokinin (CCK) acts through its receptor CCK2R to achieve largely different functions in different types of cells. CCK, CCK2R, and CB1R have all been known to have substantial effects on anxiety and other mood disorders, and the PV+ interneurons have also been shown to be involved i na variety of cognitive functions. However,  In PV+ basket cells and CCK+ basket cells, the CCK2 receptor uses different pathways to exert different effects on the two types of basket cells. For CCK+ basket cells, CCK2 receptors in neighboring pyramidal cells act through the Gq pathway to form endocannabinoids, which, through the cannabinoid receptor type 1 on the CCK+ basket cell, inhibit the release of the neurotransmitter GABA. In contrast, for PV+ basket cells, CCK2 receptors act through the pertussin-toxin sensitive Gi pathway to regulate the intracellular Ca²⁺ through ryanodine receptors. This pathway ultimately leads to activation of a non-selective cationic conductance to depolarize the PV+ basket cells." ;
        dcterms:identifier      "WP3679" ;
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        cito:cites              <https://identifiers.org/pubmed/21795548> , <https://identifiers.org/pubmed/21173082> ;
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        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
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        foaf:page               <http://www.wikipathways.org/instance/WP3679_r140517> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/iddcb9dd99>
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        wp:participants   <https://identifiers.org/chebi/CHEBI:29108> .

<https://identifiers.org/ensembl/ENSG00000144935>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TRPC1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000144935> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000144935" ;
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        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TLK5> , <https://identifiers.org/uniprot/H7C508> , <https://identifiers.org/uniprot/P48995> ;
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        owl:sameAs          <http://purl.uniprot.org/uniprot/H7C508> , <http://purl.uniprot.org/uniprot/A0A8V8TLK5> , <http://purl.uniprot.org/uniprot/P48995> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000144935> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/Complex/bcc43>
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Group/bcc43> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000110148> , <https://identifiers.org/ensembl/ENSG00000156052> .

<https://identifiers.org/pubmed/21173082>
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        dc:source           "PubMed" ;
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/21173082> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/ComplexBinding/f4f1f>
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<https://identifiers.org/wikidata/Q27089044>
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        rdfs:label          "U-73122" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/LUFAORPFSVMJIW-ZRJUGLEFSA-N> ;
        dc:identifier       <https://identifiers.org/wikidata/Q27089044> ;
        dc:source           "Wikidata" ;
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        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:90690> ;
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        wp:bdbInChIKey      <https://identifiers.org/inchikey/LUFAORPFSVMJIW-ZRJUGLEFSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID104794> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27089044> ;
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        foaf:page           <https://scholia.toolforge.org/Q27089044> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/idf65f9f23>
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/idf65f9f23> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000110148> , <https://identifiers.org/pubchem.compound/122130> ;
        wp:source         <https://identifiers.org/pubchem.compound/122130> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000110148> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/ide0f0dcf0>
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        wp:participants   <https://identifiers.org/chebi/CHEBI:18035> , <https://identifiers.org/ensembl/ENSG00000134780> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000134780> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:18035> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id32ed8cbf>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id32ed8cbf> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000182621> , <https://identifiers.org/wikidata/Q27089044> ;
        wp:source         <https://identifiers.org/wikidata/Q27089044> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000182621> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/idfc0cf358>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/idfc0cf358> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000150995> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/iddcb9dd99> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000150995> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/iddcb9dd99> .

<https://identifiers.org/ensembl/ENSG00000004468>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ADP-Ribose cyclase" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000004468> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000004468" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000004468> ;
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        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD38> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0Y950> , <https://identifiers.org/uniprot/P28907> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14885119> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/fd9ba> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28907> , <http://purl.uniprot.org/uniprot/H0Y950> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000004468> .

<https://identifiers.org/ensembl/ENSG00000118432>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CB1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000118432> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000118432" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/idbe4fea9a> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id9a8ecce4> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118432> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1268> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CNR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/S5TLS4> , <https://identifiers.org/uniprot/V5KA96> , <https://identifiers.org/uniprot/F8W187> , <https://identifiers.org/uniprot/F8W908> , <https://identifiers.org/uniprot/P21554> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q21163314> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/fc303> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P21554> , <http://purl.uniprot.org/uniprot/F8W908> , <http://purl.uniprot.org/uniprot/S5TLS4> , <http://purl.uniprot.org/uniprot/V5KA96> , <http://purl.uniprot.org/uniprot/F8W187> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000118432> .

<https://identifiers.org/ensembl/ENSG00000182621>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PLCB1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000182621> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000182621" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3679_r140517> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id65c80b61> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id9f53f011> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id32ed8cbf> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000182621> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/23236> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B1AK73> , <https://identifiers.org/uniprot/Q9NQ66> , <https://identifiers.org/uniprot/A0A0D9SG17> , <https://identifiers.org/uniprot/A0A0D9SF51> , <https://identifiers.org/uniprot/A0A1B0GW62> , <https://identifiers.org/uniprot/A0A0D9SFJ4> , <https://identifiers.org/uniprot/A0A1B0GWB6> , <https://identifiers.org/uniprot/Q8IV91> , <https://identifiers.org/uniprot/Q8IV92> , <https://identifiers.org/uniprot/A0A1B0GVC1> , <https://identifiers.org/uniprot/A0A1B0GW45> , <https://identifiers.org/uniprot/H0YCJ2> , <https://identifiers.org/uniprot/A0A1B0GVT0> , <https://identifiers.org/uniprot/A0A0D9SFE7> , <https://identifiers.org/uniprot/A0A1B0GTC7> , <https://identifiers.org/uniprot/A0A0D9SGI7> , <https://identifiers.org/uniprot/A0A0D9SFA6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18037023> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/f5209> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0D9SGI7> , <http://purl.uniprot.org/uniprot/A0A1B0GW45> , <http://purl.uniprot.org/uniprot/A0A0D9SG17> , <http://purl.uniprot.org/uniprot/A0A0D9SFJ4> , <http://purl.uniprot.org/uniprot/Q8IV91> , <http://purl.uniprot.org/uniprot/A0A1B0GVT0> , <http://purl.uniprot.org/uniprot/A0A0D9SFA6> , <http://purl.uniprot.org/uniprot/B1AK73> , <http://purl.uniprot.org/uniprot/A0A1B0GW62> , <http://purl.uniprot.org/uniprot/Q8IV92> , <http://purl.uniprot.org/uniprot/H0YCJ2> , <http://purl.uniprot.org/uniprot/A0A0D9SF51> , <http://purl.uniprot.org/uniprot/A0A1B0GTC7> , <http://purl.uniprot.org/uniprot/Q9NQ66> , <http://purl.uniprot.org/uniprot/A0A1B0GWB6> , <http://purl.uniprot.org/uniprot/A0A0D9SFE7> , <http://purl.uniprot.org/uniprot/A0A1B0GVC1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000182621> .

<https://identifiers.org/ensembl/ENSG00000196218>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RYR1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000196218> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000196218" ;
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        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000196218> ;
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        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RYR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/M0R1U6> , <https://identifiers.org/uniprot/M0R127> , <https://identifiers.org/uniprot/P21817> , <https://identifiers.org/uniprot/M0R0S0> , <https://identifiers.org/uniprot/A0A8I5KUY6> , <https://identifiers.org/uniprot/A0A8I5KSR1> , <https://identifiers.org/uniprot/M0R014> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031340> ;
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        foaf:page           <https://www.ensembl.org/id/ENSG00000196218> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/ComplexBinding/bcc43>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
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<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP3679&oldid=140517>
        rdf:type        foaf:Image ;
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<https://identifiers.org/chebi/CHEBI:29108>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ca²⁺" ;
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        dc:identifier       <https://identifiers.org/chebi/CHEBI:29108> ;
        dc:source           "ChEBI" ;
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        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29108> ;
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        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000464> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00076> ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29108> .

<https://identifiers.org/wikidata/Q4596857>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "2-APB" ;
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        foaf:page           <https://scholia.toolforge.org/Q4596857> .

<https://identifiers.org/pmc/PMC9473477>
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        dc:source           "PubMed Central" ;
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        cito:cites          <https://identifiers.org/wikipathways/WP3679> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9473477> .

<https://identifiers.org/chemspider/116>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "GABA" ;
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        dc:identifier       <https://identifiers.org/chemspider/116> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "116" ;
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        owl:sameAs          <https://www.lipidmaps.org/rdf/LMFA01100039> ;
        foaf:page           <https://www.chemspider.com/116> .

<https://identifiers.org/chebi/CHEBI:67197>
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        rdfs:label          "endocannabinoids" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:67197> ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:67197> .

<https://identifiers.org/chebi/CHEBI:42638>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Flufenamic acid" ;
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        dc:identifier       <https://identifiers.org/chebi/CHEBI:42638> ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:42638> .

<https://identifiers.org/ensembl/ENSG00000110148>
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        rdfs:label          "CCK2R" ;
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        dc:source           "Ensembl" ;
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<https://identifiers.org/pmc/PMC8912249>
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<https://identifiers.org/ensembl/ENSG00000187094>
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        foaf:page           <https://www.ensembl.org/id/ENSG00000187094> .

<https://identifiers.org/wikipathways/WP3679>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP3679_r140517> .

<https://identifiers.org/ensembl/ENSG00000150995>
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        rdfs:label          "IP3 receptor" ;
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        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A3B3IS59> , <http://purl.uniprot.org/uniprot/Q14643> , <http://purl.uniprot.org/uniprot/A0A3B3ITM6> , <http://purl.uniprot.org/uniprot/A0A3B3IU13> , <http://purl.uniprot.org/uniprot/A0A3F2YNW8> , <http://purl.uniprot.org/uniprot/A0A3B3ITQ4> , <http://purl.uniprot.org/uniprot/A0A3B3ISR4> , <http://purl.uniprot.org/uniprot/A0A3B3ISE3> , <http://purl.uniprot.org/uniprot/A0A3B3IU05> , <http://purl.uniprot.org/uniprot/A0A3B3ITU8> , <http://purl.uniprot.org/uniprot/A0A3B3IRT5> , <http://purl.uniprot.org/uniprot/A0A3B3ITM1> , <http://purl.uniprot.org/uniprot/A0A8C8KBY2> , <http://purl.uniprot.org/uniprot/A0A3B3IU04> , <http://purl.uniprot.org/uniprot/B7ZMI3> , <http://purl.uniprot.org/uniprot/A0A3B3ITQ1> , <http://purl.uniprot.org/uniprot/A0A3B3IRP0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000150995> .

<http://rdf.wikipathways.org/Pathway/WP3679_r140517/WP/Interaction/id655e8be6>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3679_r140517> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3679_r140517/Interaction/id655e8be6> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000144935> , <https://identifiers.org/chebi/CHEBI:29108> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:29108> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000144935> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3679&oldid=140517>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/chebi/CHEBI:29101>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Na⁺" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FKNQFGJONOIPTF-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:29101> ;
        dc:source           "ChEBI" ;
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        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29101> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/899> ;
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        wp:bdbInChIKey      <https://identifiers.org/inchikey/FKNQFGJONOIPTF-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01330> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID923> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/de925> , <http://rdf.wikipathways.org/Pathway/WP3679_r140517/DataNode/d22c6> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29101> .
