@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c4468>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/c4468> ;
        wp:participants   <https://identifiers.org/ncbigene/185> , <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:target         <https://identifiers.org/ncbigene/185> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/d74bc>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/d74bc> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0001035> , <https://identifiers.org/pubchem.compound/3081372> ;
        wp:source         <https://identifiers.org/pubchem.compound/3081372> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0001035> .

<https://identifiers.org/pubmed/18729003>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "18729003" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/4306> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18729003> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c353b>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/c353b> ;
        wp:participants   <https://identifiers.org/ncbigene/1636> , <https://identifiers.org/chebi/CHEBI:35457> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:35457> ;
        wp:target         <https://identifiers.org/ncbigene/1636> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a21fb>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/a21fb> ;
        wp:participants   <https://identifiers.org/ncbigene/4306> , <https://identifiers.org/hmdb/HMDB0000037> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0000037> ;
        wp:target         <https://identifiers.org/ncbigene/4306> .

<https://identifiers.org/kegg.compound/C15852>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ang 1-5" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/UVPBVMCAVNABKX-GXYVSGTKSA-N> ;
        dc:identifier       <https://identifiers.org/kegg.compound/C15852> ;
        dc:source           "KEGG Compound" ;
        dcterms:identifier  "C15852" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f8c76> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:147375> , <https://identifiers.org/chebi/CHEBI:80129> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/UVPBVMCAVNABKX-GXYVSGTKSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C15852> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID146026575> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9874518> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q58310855> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/b298c> ;
        foaf:page           <http://www.genome.jp/dbget-bin/www_bget?cpd:C15852> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f0f9a>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/f0f9a> ;
        wp:participants   <https://identifiers.org/ncbigene/59272> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a24b1> ;
        wp:source         <https://identifiers.org/ncbigene/59272> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a24b1> .

<https://identifiers.org/pubmed/15174896>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "15174896" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/1636> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/15174896> .

<https://identifiers.org/ncbigene/1585>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CYP11B2" ;
        dc:identifier       <https://identifiers.org/ncbigene/1585> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1585" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/bb339> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        dcterms:references  <https://identifiers.org/pubmed/15134803> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000179142> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1585> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP11B2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P19099> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/e14ac> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P19099> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1585> .

<https://identifiers.org/ncbigene/3827>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "KNG1" ;
        dc:identifier       <https://identifiers.org/ncbigene/3827> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "3827" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/aa8ff> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000113889> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3827> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KNG1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01042> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/cc0b4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01042> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/3827> .

<https://identifiers.org/ncbigene/1636>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ACE" ;
        dc:identifier       <https://identifiers.org/ncbigene/1636> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1636" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f744e> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/d5bc3> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c353b> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f3f2e> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        dcterms:references  <https://identifiers.org/pubmed/15174896> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000159640> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1636> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACE> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3QLR4> , <https://identifiers.org/uniprot/J3QSC7> , <https://identifiers.org/uniprot/J3KS28> , <https://identifiers.org/uniprot/J3KRH5> , <https://identifiers.org/uniprot/P12821> , <https://identifiers.org/uniprot/J3KTB8> , <https://identifiers.org/uniprot/J3KTH9> , <https://identifiers.org/uniprot/J3KSQ5> , <https://identifiers.org/uniprot/A0A0A0MSN4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/d046f> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/d6f1e> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/ef1f3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0A0MSN4> , <http://purl.uniprot.org/uniprot/J3KTB8> , <http://purl.uniprot.org/uniprot/P12821> , <http://purl.uniprot.org/uniprot/J3KRH5> , <http://purl.uniprot.org/uniprot/J3KSQ5> , <http://purl.uniprot.org/uniprot/J3KTH9> , <http://purl.uniprot.org/uniprot/J3QSC7> , <http://purl.uniprot.org/uniprot/J3KS28> , <http://purl.uniprot.org/uniprot/J3QLR4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1636> .

<https://identifiers.org/ncbigene/183>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AGT" ;
        dc:identifier       <https://identifiers.org/ncbigene/183> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "183" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a76b3> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135744> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/183> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AGT> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7P0TA52> , <https://identifiers.org/uniprot/P01019> , <https://identifiers.org/uniprot/A0A7P0T9S6> , <https://identifiers.org/uniprot/A0A7P0T8D1> , <https://identifiers.org/uniprot/A0A7P0TAP4> , <https://identifiers.org/uniprot/A0A7P0Z441> , <https://identifiers.org/uniprot/A0A7P0TBH1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/e89d5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0TBH1> , <http://purl.uniprot.org/uniprot/A0A7P0T8D1> , <http://purl.uniprot.org/uniprot/P01019> , <http://purl.uniprot.org/uniprot/A0A7P0TAP4> , <http://purl.uniprot.org/uniprot/A0A7P0TA52> , <http://purl.uniprot.org/uniprot/A0A7P0Z441> , <http://purl.uniprot.org/uniprot/A0A7P0T9S6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/183> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/bf0c1>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/bf0c1> ;
        wp:participants   <https://identifiers.org/ncbigene/186> , <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:target         <https://identifiers.org/ncbigene/186> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f3f2e>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/f3f2e> ;
        wp:participants   <https://identifiers.org/ncbigene/1636> , <https://identifiers.org/chebi/CHEBI:35457> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:35457> ;
        wp:target         <https://identifiers.org/ncbigene/1636> .

<https://identifiers.org/ncbigene/10159>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ATP6AP2" ;
        dc:identifier       <https://identifiers.org/ncbigene/10159> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "10159" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/ec371> ;
        dcterms:references  <https://identifiers.org/pubmed/18417113> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000182220> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10159> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ATP6AP2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A1B0GTU8> , <https://identifiers.org/uniprot/A0A1B0GW13> , <https://identifiers.org/uniprot/A0A1B0GVZ1> , <https://identifiers.org/uniprot/A0A1B0GUV3> , <https://identifiers.org/uniprot/A0A1B0GUT7> , <https://identifiers.org/uniprot/A0A1B0GVB9> , <https://identifiers.org/uniprot/B7Z1I9> , <https://identifiers.org/uniprot/A0A1B0GVC7> , <https://identifiers.org/uniprot/A0A1B0GVW0> , <https://identifiers.org/uniprot/H7C240> , <https://identifiers.org/uniprot/B7Z413> , <https://identifiers.org/uniprot/A0A1B0GU12> , <https://identifiers.org/uniprot/A0A1B0GTB0> , <https://identifiers.org/uniprot/A0A1B0GWJ8> , <https://identifiers.org/uniprot/A0A1C7CYW4> , <https://identifiers.org/uniprot/A0A1B0GWD6> , <https://identifiers.org/uniprot/H7C3E1> , <https://identifiers.org/uniprot/A0A1B0GV60> , <https://identifiers.org/uniprot/A0A1B0GVI9> , <https://identifiers.org/uniprot/O75787> , <https://identifiers.org/uniprot/A0A1B0GV24> , <https://identifiers.org/uniprot/A0A1B0GTD6> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/ee619> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A1B0GUV3> , <http://purl.uniprot.org/uniprot/A0A1B0GVI9> , <http://purl.uniprot.org/uniprot/A0A1B0GW13> , <http://purl.uniprot.org/uniprot/O75787> , <http://purl.uniprot.org/uniprot/H7C240> , <http://purl.uniprot.org/uniprot/A0A1B0GTB0> , <http://purl.uniprot.org/uniprot/B7Z1I9> , <http://purl.uniprot.org/uniprot/A0A1B0GVB9> , <http://purl.uniprot.org/uniprot/H7C3E1> , <http://purl.uniprot.org/uniprot/A0A1B0GVW0> , <http://purl.uniprot.org/uniprot/A0A1B0GU12> , <http://purl.uniprot.org/uniprot/A0A1B0GWJ8> , <http://purl.uniprot.org/uniprot/A0A1B0GVC7> , <http://purl.uniprot.org/uniprot/A0A1B0GTD6> , <http://purl.uniprot.org/uniprot/A0A1B0GUT7> , <http://purl.uniprot.org/uniprot/A0A1C7CYW4> , <http://purl.uniprot.org/uniprot/B7Z413> , <http://purl.uniprot.org/uniprot/A0A1B0GTU8> , <http://purl.uniprot.org/uniprot/A0A1B0GVZ1> , <http://purl.uniprot.org/uniprot/A0A1B0GWD6> , <http://purl.uniprot.org/uniprot/A0A1B0GV24> , <http://purl.uniprot.org/uniprot/A0A1B0GV60> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/10159> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a0cae>
        rdf:type            wp:Interaction , wp:Catalysis , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> ;
        dcterms:references  <https://identifiers.org/pubmed/18035185> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/a0cae> ;
        wp:participants     <https://identifiers.org/ncbigene/1215> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a45d0> ;
        wp:source           <https://identifiers.org/ncbigene/1215> ;
        wp:target           <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a45d0> .

<https://identifiers.org/kegg.compound/C15851>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Ang 1-9" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/LJXGOQOPNPFXFT-JWRYNVNRSA-N> ;
        dc:identifier       <https://identifiers.org/kegg.compound/C15851> ;
        dc:source           "KEGG Compound" ;
        dcterms:identifier  "C15851" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/dd7bd> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a24b1> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:80128> , <https://identifiers.org/chebi/CHEBI:147351> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/LJXGOQOPNPFXFT-JWRYNVNRSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C15851> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID71745056> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID146026568> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q58310864> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/fbc8b> ;
        foaf:page           <http://www.genome.jp/dbget-bin/www_bget?cpd:C15851> .

<https://identifiers.org/ncbigene/4142>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAS1" ;
        dc:identifier       <https://identifiers.org/ncbigene/4142> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4142" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/ef46a> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        dcterms:references  <https://identifiers.org/pubmed/18449520> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130368> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4142> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAS1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/W8W3P4> , <https://identifiers.org/uniprot/P04201> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/e3012> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/W8W3P4> , <http://purl.uniprot.org/uniprot/P04201> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4142> .

<https://identifiers.org/pubchem.compound/114805>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Prostacyclin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/KAQKFAOMNZTLHT-IJCBKZNRSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/114805> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "114805" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c6bfc> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/102770> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/KAQKFAOMNZTLHT-IJCBKZNRSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID114805> ;
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<https://identifiers.org/wikipathways/WP554>
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        wp:target         <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/eaace> .

<https://identifiers.org/chemspider/110354>
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<https://identifiers.org/ncbigene/59272>
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        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/59272> .

<https://identifiers.org/pubmed/18417113>
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18417113> .

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        wp:source         <https://identifiers.org/chebi/CHEBI:35457> ;
        wp:target         <https://identifiers.org/ncbigene/1636> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP554&oldid=139872>
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<https://identifiers.org/hmdb/HMDB0000016>
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        rdfs:label          "Deoxycorticosterone" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZESRJSPZRDMNHY-YFWFAHHUSA-N> ;
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        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C03205> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST02030087> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6166> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q948846> ;
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        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST02030087> , <https://swisslipids.org/rdf/SLM_000485330> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000016> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/d8d51>
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        wp:source         <https://identifiers.org/ncbigene/5972> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a76b3> .

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<https://identifiers.org/ncbigene/186>
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        dc:identifier       <https://identifiers.org/ncbigene/186> ;
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        dcterms:references  <https://identifiers.org/pubmed/18035185> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/b1122> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P50052> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/186> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f744e>
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        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/f744e> ;
        wp:participants   <https://identifiers.org/ncbigene/1636> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/aa8ff> ;
        wp:source         <https://identifiers.org/ncbigene/1636> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/aa8ff> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/aa8ff>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/aa8ff> ;
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        wp:source         <https://identifiers.org/ncbigene/3827> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0004246> .

<https://identifiers.org/pmc/PMC7982796>
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        dcterms:identifier  "PMC7982796" ;
        cito:cites          <https://identifiers.org/wikipathways/WP554> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC7982796> .

<https://identifiers.org/ncbigene/623>
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        rdfs:label          "BDKRB1" ;
        dc:identifier       <https://identifiers.org/ncbigene/623> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "623" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a6f8b> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100739> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/623> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BDKRB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P46663> , <https://identifiers.org/uniprot/G3V4Y2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/b4349> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V4Y2> , <http://purl.uniprot.org/uniprot/P46663> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/623> .

<https://identifiers.org/hmdb/HMDB0004246>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Bradykinin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/QXZGBUJJYSLZLT-FDISYFBBSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0004246> ;
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        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:3165> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388341> ;
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        wp:bdbInChIKey      <https://identifiers.org/inchikey/QXZGBUJJYSLZLT-FDISYFBBSA-N> ;
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        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439201> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/c496e> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0004246> .

<https://identifiers.org/pubmed/17464936>
        rdf:type            wp:PublicationReference ;
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        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17464936> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f3a74>
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/f3a74> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0001035> , <https://identifiers.org/pubchem.compound/3081372> ;
        wp:source         <https://identifiers.org/pubchem.compound/3081372> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0001035> .

<https://identifiers.org/hmdb/HMDB0001035>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin II" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/CZGUSIXMZVURDU-JZXHSEFVSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001035> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001035" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/bf0c1> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c4468> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/d4ea3> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f3a74> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/d74bc> , <https://identifiers.org/wikipathways/WP554_r139872> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a45d0> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:2719> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/150504> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/CZGUSIXMZVURDU-JZXHSEFVSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C02135> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID172198> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q412999> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/ca3ad> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0001035> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f8c76>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/f8c76> ;
        wp:participants   <https://identifiers.org/kegg.compound/C15852> , <https://identifiers.org/chemspider/110354> ;
        wp:source         <https://identifiers.org/chemspider/110354> ;
        wp:target         <https://identifiers.org/kegg.compound/C15852> .

<https://identifiers.org/chebi/CHEBI:35457>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "ACE inhibitor" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:35457> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:35457" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP554_r139872> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/d5bc3> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c353b> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/f3f2e> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:35457> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q288280> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/d9620> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35457> .

<https://identifiers.org/ncbigene/185>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "AGTR1" ;
        dc:identifier       <https://identifiers.org/ncbigene/185> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "185" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c4468> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000144891> ;
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        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AGTR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P30556> , <https://identifiers.org/uniprot/D3DNG8> , <https://identifiers.org/uniprot/A0A0A0MSE3> , <https://identifiers.org/uniprot/Q53YY0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/b4811> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P30556> , <http://purl.uniprot.org/uniprot/D3DNG8> , <http://purl.uniprot.org/uniprot/Q53YY0> , <http://purl.uniprot.org/uniprot/A0A0A0MSE3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/185> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/c6bfc>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/c6bfc> ;
        wp:participants   <https://identifiers.org/pubchem.compound/114805> , <https://identifiers.org/ncbigene/624> ;
        wp:source         <https://identifiers.org/ncbigene/624> ;
        wp:target         <https://identifiers.org/pubchem.compound/114805> .

<https://identifiers.org/wikipathways/WP554_r139872>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP554> ;
        dc:source               "WikiPathways" ;
        dc:title                "ACE inhibitor pathway"@en ;
        dcterms:description     "The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure.\n\nSource: PharmGKB (https://www.pharmgkb.org/pathway/PA2023)\n\nProteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP554)" ;
        dcterms:identifier      "WP554" ;
        dcterms:references      <https://identifiers.org/pubmed/17464936> ;
        cito:cites              <https://identifiers.org/pubmed/15174896> , <https://identifiers.org/pubmed/17464936> , <https://identifiers.org/pubmed/18449520> , <https://identifiers.org/pubmed/18729003> , <https://identifiers.org/pubmed/18417113> , <https://identifiers.org/pubmed/15134803> , <https://identifiers.org/pubmed/16374430> , <https://identifiers.org/pubmed/18035185> ;
        wp:cellTypeOntologyTag  obo:CL_0000650 ;
        wp:diseaseOntologyTag   obo:DOID_10763 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP554_r139872> ;
        wp:ontologyTag          obo:PW_0000003 , wp:Curation:Renal_Genomics , wp:Curation:ONTOX , obo:PW_0001228 , obo:CL_0000650 , obo:PW_0000245 , wp:Curation:AnalysisCollection , obo:DOID_10763 ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000245 , obo:PW_0000003 , obo:PW_0001228 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP554&oldid=139872> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP554&oldid=139872> ;
        foaf:page               <http://www.wikipathways.org/instance/WP554_r139872> .

<https://identifiers.org/pubmed/18035185>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "18035185" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/e54f1> , <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/a0cae> , <https://identifiers.org/ncbigene/186> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18035185> .

<https://identifiers.org/pmc/PMC10775474>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC10775474" ;
        cito:cites          <https://identifiers.org/wikipathways/WP554> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC10775474> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/bed79>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/bed79> ;
        wp:participants   <https://identifiers.org/ncbigene/624> , <https://identifiers.org/hmdb/HMDB0004246> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0004246> ;
        wp:target         <https://identifiers.org/ncbigene/624> .

<http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/ef46a>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP554_r139872/Interaction/ef46a> ;
        wp:participants   <https://identifiers.org/ncbigene/4142> , <https://identifiers.org/chemspider/110354> ;
        wp:source         <https://identifiers.org/chemspider/110354> ;
        wp:target         <https://identifiers.org/ncbigene/4142> .

<https://identifiers.org/ncbigene/1511>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CTSG" ;
        dc:identifier       <https://identifiers.org/ncbigene/1511> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1511" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP554_r139872/WP/Interaction/e54f1> , <https://identifiers.org/wikipathways/WP554_r139872> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100448> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1511> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CTSG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P08311> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP554_r139872/DataNode/c9ca8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P08311> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1511> .
