@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/wikipathways/WP4585_r141030>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP4585> ;
        dc:source               "WikiPathways" ;
        dc:title                "Cancer immunotherapy by PD-1 blockade"@en ;
        dcterms:description     "Immune checkpoints are hardwired into the immune system and are crucial for maintaining self-tolerance. Tumors can use these checkpoints to protect themselves from immune system attacks. \nOne such immune checkpoint is PD-1 (programmed cell death 1 protein), which binds to its ligand PD-L1 and inhibits immune cell activity, including T cell activity. By upregulating PD-L1, cancer cells can inhibit T cells that might otherwise attack.  One strategy for cancer immunotherapy is to block this kind of negative feedback, thereby increasing anti-cancer T-cell activity. For the PD-1 checkpoint, cancer immunotherapeutics block either the PD-1 receptor, or the PD-L1 ligand.\nThe [2018 Nobel prize in Physiology or Medicine](https://www.nobelprize.org/prizes/medicine/2018/summary/) was awarded to jointly to James Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.\n\nBased on and figure 4B in the review by [Pardoll](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856023/) and figure 1 in the review by [Sharpe and Pauken](https://www.ncbi.nlm.nih.gov/pubmed/28990585).\n" ;
        dcterms:identifier      "WP4585" ;
        dcterms:references      <https://identifiers.org/pubmed/30511409> , <https://identifiers.org/pubmed/22437870> , <https://identifiers.org/pubmed/28990585> , <https://identifiers.org/pubmed/25514926> ;
        cito:cites              <https://identifiers.org/pubmed/28990585> , <https://identifiers.org/pubmed/30511409> , <https://identifiers.org/pubmed/22437870> , <https://identifiers.org/pubmed/25514926> ;
        wp:cellTypeOntologyTag  obo:CL_0001063 , obo:CL_0000084 ;
        wp:diseaseOntologyTag   obo:DOID_162 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP4585_r141030> ;
        wp:ontologyTag          obo:PW_0000605 , wp:Curation:CPTAC , obo:CL_0001063 , obo:DOID_162 , wp:Curation:AnalysisCollection , obo:CL_0000084 , obo:PW_0000235 ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000605 , obo:PW_0000235 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4585&oldid=141030> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4585&oldid=141030> ;
        foaf:page               <http://www.wikipathways.org/instance/WP4585_r141030> .

<https://identifiers.org/ensembl/ENSG00000131196>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NFATC1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000131196> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000131196" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000131196> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4772> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFATC1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5H4S8> , <https://identifiers.org/uniprot/K7ER53> , <https://identifiers.org/uniprot/O95644> , <https://identifiers.org/uniprot/K7EQ04> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030068> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/f9482> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F5H4S8> , <http://purl.uniprot.org/uniprot/K7ER53> , <http://purl.uniprot.org/uniprot/K7EQ04> , <http://purl.uniprot.org/uniprot/O95644> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000131196> .

<https://identifiers.org/pubmed/28990585>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "28990585" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/28990585> .

<https://identifiers.org/wikidata/Q13896859>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Pembrolizumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q13896859> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q13896859" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID254741536> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q13896859> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ac967> ;
        foaf:page           <https://scholia.toolforge.org/Q13896859> .

<https://identifiers.org/ensembl/ENSG00000101096>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NFATC2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000101096> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000101096" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000101096> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4773> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFATC2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q13469> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030071> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/c5fef> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q13469> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000101096> .

<https://identifiers.org/wikidata/Q7041828>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Nivolumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q7041828> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q7041828" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q7041828> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/cc867> ;
        foaf:page           <https://scholia.toolforge.org/Q7041828> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id233b9269>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/id233b9269> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000188389> , <https://identifiers.org/ensembl/ENSG00000120217> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000120217> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000188389> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4585&oldid=141030>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/wikipathways/WP4585>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4585_r141030> .

<https://identifiers.org/ensembl/ENSG00000160654>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CD3G" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000160654> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000160654" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000160654> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/917> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD3G> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B0YIY5> , <https://identifiers.org/uniprot/P09693> , <https://identifiers.org/uniprot/A0A3B3IUD8> , <https://identifiers.org/uniprot/A8MUH3> , <https://identifiers.org/uniprot/J3KNA5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17857730> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/d8903> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3KNA5> , <http://purl.uniprot.org/uniprot/B0YIY5> , <http://purl.uniprot.org/uniprot/A8MUH3> , <http://purl.uniprot.org/uniprot/A0A3B3IUD8> , <http://purl.uniprot.org/uniprot/P09693> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000160654> .

<https://identifiers.org/pubmed/30511409>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "30511409" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/30511409> .

<https://identifiers.org/ensembl/ENSG00000206503>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "MHC I" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000206503> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000206503" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/cf5ce> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000206503> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3105> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HLA-A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A238TQ66> , <https://identifiers.org/uniprot/B1PKY1> , <https://identifiers.org/uniprot/Q5SRN7> , <https://identifiers.org/uniprot/P04439> , <https://identifiers.org/uniprot/A0A1W2PS24> , <https://identifiers.org/uniprot/Q5SRN5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/cf68e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A238TQ66> , <http://purl.uniprot.org/uniprot/Q5SRN5> , <http://purl.uniprot.org/uniprot/B1PKY1> , <http://purl.uniprot.org/uniprot/A0A1W2PS24> , <http://purl.uniprot.org/uniprot/Q5SRN7> , <http://purl.uniprot.org/uniprot/P04439> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000206503> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id7ed4b1c1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/id7ed4b1c1> ;
        wp:participants   <https://identifiers.org/wikipathways/WP4223> , <https://identifiers.org/ensembl/ENSG00000115085> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000115085> ;
        wp:target         <https://identifiers.org/wikipathways/WP4223> .

<https://identifiers.org/pubmed/22437870>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "22437870" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/22437870> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id3dfabd77>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/id3dfabd77> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000156127> , <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000156127> .

<https://identifiers.org/wikipathways/WP4172>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "PI3K signaling" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP4172> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP4172" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id52d664a5> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/idfba37d0> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/deab0> ;
        foaf:page           <https://www.wikipathways.org/instance/WP4172> .

<https://identifiers.org/wikidata/Q7191298>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Pidilizumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q7191298> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q7191298" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q7191298> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/d9d18> ;
        foaf:page           <https://scholia.toolforge.org/Q7191298> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Group/ac0b9> ;
        wp:participants   <https://identifiers.org/ncbigene/6955> , <https://identifiers.org/ensembl/ENSG00000160654> , <https://identifiers.org/ncbigene/6957> , <https://identifiers.org/ensembl/ENSG00000198851> , <https://identifiers.org/ensembl/ENSG00000167286> .

<https://identifiers.org/ensembl/ENSG00000188389>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PDCD1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000188389> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000188389" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id233b9269> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/ide1f72d6e> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000188389> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5133> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PDCD1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0M3M0G7> , <https://identifiers.org/uniprot/Q15116> , <https://identifiers.org/uniprot/E7ER21> , <https://identifiers.org/uniprot/H0Y2W6> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/fb005> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q15116> , <http://purl.uniprot.org/uniprot/E7ER21> , <http://purl.uniprot.org/uniprot/A0A0M3M0G7> , <http://purl.uniprot.org/uniprot/H0Y2W6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000188389> .

<https://identifiers.org/wikipathways/WP4223>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "Ras signaling" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP4223> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP4223" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id7ed4b1c1> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/d1188> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ca322> ;
        foaf:page           <https://www.wikipathways.org/instance/WP4223> .

<https://identifiers.org/ensembl/ENSG00000072736>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "NFATC3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000072736> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000072736" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000072736> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4775> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFATC3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BU30> , <https://identifiers.org/uniprot/B5B2S0> , <https://identifiers.org/uniprot/I3L3K7> , <https://identifiers.org/uniprot/F8VPH9> , <https://identifiers.org/uniprot/Q12968> , <https://identifiers.org/uniprot/H3BRS1> , <https://identifiers.org/uniprot/B5B2S1> , <https://identifiers.org/uniprot/H3BRM3> , <https://identifiers.org/uniprot/H3BR83> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030077> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/d3001> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/B5B2S1> , <http://purl.uniprot.org/uniprot/Q12968> , <http://purl.uniprot.org/uniprot/H3BU30> , <http://purl.uniprot.org/uniprot/H3BRS1> , <http://purl.uniprot.org/uniprot/H3BR83> , <http://purl.uniprot.org/uniprot/F8VPH9> , <http://purl.uniprot.org/uniprot/H3BRM3> , <http://purl.uniprot.org/uniprot/B5B2S0> , <http://purl.uniprot.org/uniprot/I3L3K7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000072736> .

<https://identifiers.org/ensembl/ENSG00000109320>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "NFKB1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000109320> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000109320" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000109320> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4790> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFKB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TLB2> , <https://identifiers.org/uniprot/D6RC45> , <https://identifiers.org/uniprot/A0A494C157> , <https://identifiers.org/uniprot/P19838> , <https://identifiers.org/uniprot/D6RH30> , <https://identifiers.org/uniprot/A0A494C1E9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15317427> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ce83f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A494C1E9> , <http://purl.uniprot.org/uniprot/A0A494C157> , <http://purl.uniprot.org/uniprot/D6RC45> , <http://purl.uniprot.org/uniprot/A0A8V8TLB2> , <http://purl.uniprot.org/uniprot/P19838> , <http://purl.uniprot.org/uniprot/D6RH30> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000109320> .

<https://identifiers.org/ensembl/ENSG00000177606>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "JUN" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000177606> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000177606" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000177606> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3725> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/JUN> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P05412> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911907> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/e2c2e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P05412> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000177606> .

<https://identifiers.org/ensembl/ENSG00000115085>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ZAP70" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000115085> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000115085" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id12ce76b1> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id7ed4b1c1> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id52d664a5> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115085> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7535> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ZAP70> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P43403> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14907110> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ef0fd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P43403> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000115085> .

<https://identifiers.org/ensembl/ENSG00000179295>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PTPN11" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000179295> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000179295" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id3dfabd77> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/idfba37d0> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id9baa23b1> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id12ce76b1> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/d1188> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5781> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTPN11> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5QL30> , <https://identifiers.org/uniprot/A0A8I5KRZ3> , <https://identifiers.org/uniprot/A0A8I5KW48> , <https://identifiers.org/uniprot/H0YF12> , <https://identifiers.org/uniprot/A0A1W2PPU4> , <https://identifiers.org/uniprot/A0A8I5KVS6> , <https://identifiers.org/uniprot/A0A0U1RRI0> , <https://identifiers.org/uniprot/A0A8I5QJ58> , <https://identifiers.org/uniprot/Q06124> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905494> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/fb739> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KVS6> , <http://purl.uniprot.org/uniprot/A0A0U1RRI0> , <http://purl.uniprot.org/uniprot/A0A1W2PPU4> , <http://purl.uniprot.org/uniprot/A0A8I5KRZ3> , <http://purl.uniprot.org/uniprot/A0A8I5QL30> , <http://purl.uniprot.org/uniprot/Q06124> , <http://purl.uniprot.org/uniprot/A0A8I5KW48> , <http://purl.uniprot.org/uniprot/A0A8I5QJ58> , <http://purl.uniprot.org/uniprot/H0YF12> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000179295> .

<https://identifiers.org/ensembl/ENSG00000102908>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NFAT5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000102908> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000102908" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102908> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10725> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFAT5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A499FJX5> , <https://identifiers.org/uniprot/O94916> , <https://identifiers.org/uniprot/J3QKS5> , <https://identifiers.org/uniprot/J3KRL6> , <https://identifiers.org/uniprot/H3BP21> , <https://identifiers.org/uniprot/A0A494C020> , <https://identifiers.org/uniprot/A0A499FIS8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18035626> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/b49a8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O94916> , <http://purl.uniprot.org/uniprot/H3BP21> , <http://purl.uniprot.org/uniprot/A0A499FJX5> , <http://purl.uniprot.org/uniprot/A0A499FIS8> , <http://purl.uniprot.org/uniprot/J3QKS5> , <http://purl.uniprot.org/uniprot/A0A494C020> , <http://purl.uniprot.org/uniprot/J3KRL6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000102908> .

<https://identifiers.org/wikidata/Q21083261>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Avelumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q21083261> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q21083261" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q21083261> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/e9da1> ;
        foaf:page           <https://scholia.toolforge.org/Q21083261> .

<https://identifiers.org/ncbigene/6957>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TRB" ;
        dc:identifier       <https://identifiers.org/ncbigene/6957> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6957" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6957> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/c44ef> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6957> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/idfba37d0>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/idfba37d0> ;
        wp:participants   <https://identifiers.org/wikipathways/WP4172> , <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:target         <https://identifiers.org/wikipathways/WP4172> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/pmc/PMC8751594>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC8751594" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4585> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC8751594> .

<https://identifiers.org/ensembl/ENSG00000197646>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PDCD1LG2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000197646> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000197646" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/ide1f72d6e> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000197646> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/80380> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PDCD1LG2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9BQ51> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18046737> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/c29ad> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9BQ51> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000197646> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id9baa23b1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/id9baa23b1> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000111537> , <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000111537> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id52d664a5>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/id52d664a5> ;
        wp:participants   <https://identifiers.org/wikipathways/WP4172> , <https://identifiers.org/ensembl/ENSG00000115085> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000115085> ;
        wp:target         <https://identifiers.org/wikipathways/WP4172> .

<https://identifiers.org/ensembl/ENSG00000153563>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CD8A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000153563> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000153563" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000153563> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/925> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD8A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01732> , <https://identifiers.org/uniprot/B8ZZZ4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17858344> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ad5ee> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01732> , <http://purl.uniprot.org/uniprot/B8ZZZ4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000153563> .

<https://identifiers.org/ensembl/ENSG00000120217>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CD274" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000120217> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000120217" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/iddb7061af> , <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id233b9269> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000120217> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/29126> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD274> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9NZQ7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18039630> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ae75d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9NZQ7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000120217> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/iddd6753bb>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/iddd6753bb> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000168610> , <https://identifiers.org/ensembl/ENSG00000111537> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000111537> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000168610> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/idfbed420c>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/idfbed420c> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000156127> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000156127> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000156127> .

<https://identifiers.org/ensembl/ENSG00000111537>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "IFNG" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000111537> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000111537" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/iddd6753bb> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id9baa23b1> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000111537> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3458> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IFNG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01579> , <https://identifiers.org/uniprot/A0A7R8GUN6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18027639> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/bbd24> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7R8GUN6> , <http://purl.uniprot.org/uniprot/P01579> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000111537> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/d1188>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/d1188> ;
        wp:participants   <https://identifiers.org/wikipathways/WP4223> , <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:target         <https://identifiers.org/wikipathways/WP4223> .

<https://identifiers.org/wikidata/Q19904005>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Durvalumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q19904005> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q19904005" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q19904005> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/e67ee> ;
        foaf:page           <https://scholia.toolforge.org/Q19904005> .

<https://identifiers.org/ensembl/ENSG00000172116>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CD8B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000172116> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000172116" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000172116> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/926> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD8B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PD41> , <https://identifiers.org/uniprot/P10966> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17858387> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/c5d3d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PD41> , <http://purl.uniprot.org/uniprot/P10966> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000172116> .

<https://identifiers.org/ensembl/ENSG00000196126>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "MHC II" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000196126> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000196126" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/cf5ce> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000196126> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3123> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HLA-DRB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/X5DNQ0> , <https://identifiers.org/uniprot/A0A8Q3WLF4> , <https://identifiers.org/uniprot/D7RIH8> , <https://identifiers.org/uniprot/P01911> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/eba63> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/X5DNQ0> , <http://purl.uniprot.org/uniprot/P01911> , <http://purl.uniprot.org/uniprot/D7RIH8> , <http://purl.uniprot.org/uniprot/A0A8Q3WLF4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000196126> .

<https://identifiers.org/wikidata/Q20707748>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Atezolizumab" ;
        dc:identifier       <https://identifiers.org/wikidata/Q20707748> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q20707748" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20707748> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/e9dc5> ;
        foaf:page           <https://scholia.toolforge.org/Q20707748> .

<https://identifiers.org/ensembl/ENSG00000156127>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "BATF" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000156127> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000156127" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id3dfabd77> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/idfbed420c> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000156127> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10538> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BATF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q16520> , <https://identifiers.org/uniprot/G3V266> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18035466> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ad8ad> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/e8b31> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q16520> , <http://purl.uniprot.org/uniprot/G3V266> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000156127> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/iddb7061af>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/iddb7061af> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000120217> , <https://identifiers.org/ensembl/ENSG00000168610> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000168610> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000120217> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/id12ce76b1>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/id12ce76b1> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000115085> , <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000115085> .

<https://identifiers.org/ensembl/ENSG00000198851>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CD3E" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198851> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198851" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198851> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/916> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD3E> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PSH8> , <https://identifiers.org/uniprot/P07766> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17857659> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/de57b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PSH8> , <http://purl.uniprot.org/uniprot/P07766> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198851> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/cf5ce>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Group/cf5ce> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000206503> , <https://identifiers.org/ensembl/ENSG00000196126> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/ComplexBinding/ac0b9>
        rdf:type          wp:Interaction , wp:ComplexBinding , wp:Binding ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Group/ac0b9> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000160654> , <https://identifiers.org/ncbigene/6957> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9> , <https://identifiers.org/ncbigene/6955> , <https://identifiers.org/ensembl/ENSG00000198851> , <https://identifiers.org/ensembl/ENSG00000167286> .

<https://identifiers.org/ensembl/ENSG00000168610>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "STAT3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000168610> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000168610" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/iddd6753bb> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/iddb7061af> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000168610> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6774> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STAT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V444> , <https://identifiers.org/uniprot/A0A7I2V552> , <https://identifiers.org/uniprot/A0A7I2YQI1> , <https://identifiers.org/uniprot/A0A7I2V4F6> , <https://identifiers.org/uniprot/A0A7I2V4R2> , <https://identifiers.org/uniprot/A0A7I2V4C8> , <https://identifiers.org/uniprot/G8JLH9> , <https://identifiers.org/uniprot/A0A7I2V395> , <https://identifiers.org/uniprot/A0A7I2V3V0> , <https://identifiers.org/uniprot/A0A7I2V5N9> , <https://identifiers.org/uniprot/P40763> , <https://identifiers.org/uniprot/A0A7I2V2T1> , <https://identifiers.org/uniprot/A0A7I2V4R3> , <https://identifiers.org/uniprot/A0A7I2V2G1> , <https://identifiers.org/uniprot/A0A7I2YQR5> , <https://identifiers.org/uniprot/A0A7I2YQD2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14912019> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/d1337> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2YQI1> , <http://purl.uniprot.org/uniprot/P40763> , <http://purl.uniprot.org/uniprot/A0A7I2V552> , <http://purl.uniprot.org/uniprot/A0A7I2V444> , <http://purl.uniprot.org/uniprot/A0A7I2YQD2> , <http://purl.uniprot.org/uniprot/A0A7I2V4R2> , <http://purl.uniprot.org/uniprot/A0A7I2V3V0> , <http://purl.uniprot.org/uniprot/A0A7I2V2G1> , <http://purl.uniprot.org/uniprot/A0A7I2V395> , <http://purl.uniprot.org/uniprot/A0A7I2V4C8> , <http://purl.uniprot.org/uniprot/A0A7I2V5N9> , <http://purl.uniprot.org/uniprot/A0A7I2YQR5> , <http://purl.uniprot.org/uniprot/A0A7I2V4R3> , <http://purl.uniprot.org/uniprot/A0A7I2V2T1> , <http://purl.uniprot.org/uniprot/A0A7I2V4F6> , <http://purl.uniprot.org/uniprot/G8JLH9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000168610> .

<https://identifiers.org/ncbigene/6955>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TRA" ;
        dc:identifier       <https://identifiers.org/ncbigene/6955> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6955" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6955> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/dedef> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6955> .

<https://identifiers.org/pubmed/25514926>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "25514926" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/25514926> .

<https://identifiers.org/ensembl/ENSG00000167286>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CD3D" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000167286> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000167286" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/ac0b9> , <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000167286> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/915> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD3D> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B0YIY4> , <https://identifiers.org/uniprot/E9PMT5> , <https://identifiers.org/uniprot/P04234> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17857590> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/ee1ad> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P04234> , <http://purl.uniprot.org/uniprot/B0YIY4> , <http://purl.uniprot.org/uniprot/E9PMT5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000167286> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/WP/Interaction/ide1f72d6e>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Interaction/ide1f72d6e> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000188389> , <https://identifiers.org/ensembl/ENSG00000197646> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000197646> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000188389> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4585&oldid=141030>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/ensembl/ENSG00000100968>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NFATC4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000100968> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000100968" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100968> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4776> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFATC4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V5H0> , <https://identifiers.org/uniprot/Q14934> , <https://identifiers.org/uniprot/G3V4K1> , <https://identifiers.org/uniprot/G3V4U6> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/dd28d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q14934> , <http://purl.uniprot.org/uniprot/G3V5H0> , <http://purl.uniprot.org/uniprot/G3V4K1> , <http://purl.uniprot.org/uniprot/G3V4U6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000100968> .

<http://rdf.wikipathways.org/Pathway/WP4585_r141030/ComplexBinding/cf5ce>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Group/cf5ce> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000206503> , <https://identifiers.org/ensembl/ENSG00000196126> , <http://rdf.wikipathways.org/Pathway/WP4585_r141030/Complex/cf5ce> .

<https://identifiers.org/ensembl/ENSG00000182866>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "LCK" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000182866> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000182866" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000182866> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3932> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/LCK> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PJ92> , <https://identifiers.org/uniprot/A0A8V8TM09> , <https://identifiers.org/uniprot/E9PKQ8> , <https://identifiers.org/uniprot/A0A0S2Z3T3> , <https://identifiers.org/uniprot/E9PQ10> , <https://identifiers.org/uniprot/E9PI33> , <https://identifiers.org/uniprot/E9PAP0> , <https://identifiers.org/uniprot/A0A8V8TKX3> , <https://identifiers.org/uniprot/P06239> , <https://identifiers.org/uniprot/A0A0S2Z3Y8> , <https://identifiers.org/uniprot/F8W6B9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14885202> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/f1abb> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PJ92> , <http://purl.uniprot.org/uniprot/E9PQ10> , <http://purl.uniprot.org/uniprot/E9PKQ8> , <http://purl.uniprot.org/uniprot/A0A8V8TKX3> , <http://purl.uniprot.org/uniprot/A0A8V8TM09> , <http://purl.uniprot.org/uniprot/P06239> , <http://purl.uniprot.org/uniprot/A0A0S2Z3Y8> , <http://purl.uniprot.org/uniprot/F8W6B9> , <http://purl.uniprot.org/uniprot/E9PI33> , <http://purl.uniprot.org/uniprot/E9PAP0> , <http://purl.uniprot.org/uniprot/A0A0S2Z3T3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000182866> .

<https://identifiers.org/kegg.drug/D11487>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Tislelizumab" ;
        dc:identifier       <https://identifiers.org/kegg.drug/D11487> ;
        dc:source           "KEGG Drug" ;
        dcterms:identifier  "D11487" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4585_r141030> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q28209583> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4585_r141030/DataNode/fdb08> ;
        foaf:page           <http://www.genome.jp/dbget-bin/www_bget?dr:D11487> .
