@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id17f347d2>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/id17f347d2> ;
        wp:participants   <https://identifiers.org/ncbigene/80142> , <https://identifiers.org/chebi/CHEBI:15843> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:15843> ;
        wp:target         <https://identifiers.org/ncbigene/80142> .

<https://identifiers.org/ncbigene/2099>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ESR1" ;
        dc:identifier       <https://identifiers.org/ncbigene/2099> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2099" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e25b9> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b3a5a> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b10f7> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000091831> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2099> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ESR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9H2M1> , <https://identifiers.org/uniprot/B0QYW7> , <https://identifiers.org/uniprot/P03372> , <https://identifiers.org/uniprot/H0Y4W6> , <https://identifiers.org/uniprot/Q9H2M2> , <https://identifiers.org/uniprot/G4XH65> , <https://identifiers.org/uniprot/Q9UE35> , <https://identifiers.org/uniprot/Q5T5H8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9UE35> , <http://purl.uniprot.org/uniprot/Q9H2M2> , <http://purl.uniprot.org/uniprot/B0QYW7> , <http://purl.uniprot.org/uniprot/P03372> , <http://purl.uniprot.org/uniprot/H0Y4W6> , <http://purl.uniprot.org/uniprot/Q9H2M1> , <http://purl.uniprot.org/uniprot/G4XH65> , <http://purl.uniprot.org/uniprot/Q5T5H8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2099> .

<https://identifiers.org/ncbigene/5291>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PI3KB" ;
        dc:identifier       <https://identifiers.org/ncbigene/5291> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5291" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c4a2d> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000051382> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5291> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C5C3> , <https://identifiers.org/uniprot/H7C565> , <https://identifiers.org/uniprot/H0Y871> , <https://identifiers.org/uniprot/H7C527> , <https://identifiers.org/uniprot/F8WDJ8> , <https://identifiers.org/uniprot/Q68DL0> , <https://identifiers.org/uniprot/C9JYX0> , <https://identifiers.org/uniprot/P42338> , <https://identifiers.org/uniprot/C9J345> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H7C5C3> , <http://purl.uniprot.org/uniprot/C9JYX0> , <http://purl.uniprot.org/uniprot/Q68DL0> , <http://purl.uniprot.org/uniprot/P42338> , <http://purl.uniprot.org/uniprot/C9J345> , <http://purl.uniprot.org/uniprot/H7C565> , <http://purl.uniprot.org/uniprot/H7C527> , <http://purl.uniprot.org/uniprot/F8WDJ8> , <http://purl.uniprot.org/uniprot/H0Y871> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5291> .

<https://identifiers.org/ncbiprotein/P01133>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "EGF" ;
        dc:identifier       <https://identifiers.org/ncbiprotein/P01133> ;
        dc:source           "NCBI Protein" ;
        dcterms:identifier  "P01133" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/ida5958e07> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/e2be2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/protein/P01133> .

<https://identifiers.org/ncbigene/5734>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PTGER4" ;
        dc:identifier       <https://identifiers.org/ncbigene/5734> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5734" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c6965> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171522> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5734> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTGER4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P35408> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/c2527> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P35408> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5734> .

<https://identifiers.org/ncbigene/207>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT1" ;
        dc:identifier       <https://identifiers.org/ncbigene/207> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "207" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e8651> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000142208> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/207> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P31749> , <https://identifiers.org/uniprot/A0A804HJM6> , <https://identifiers.org/uniprot/B0LPE5> , <https://identifiers.org/uniprot/G3V2I6> , <https://identifiers.org/uniprot/A0A087WY56> , <https://identifiers.org/uniprot/G3V3X1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V2I6> , <http://purl.uniprot.org/uniprot/B0LPE5> , <http://purl.uniprot.org/uniprot/A0A804HJM6> , <http://purl.uniprot.org/uniprot/A0A087WY56> , <http://purl.uniprot.org/uniprot/P31749> , <http://purl.uniprot.org/uniprot/G3V3X1> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/207> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idb444734d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/idb444734d> ;
        wp:participants   <https://identifiers.org/ncbigene/5743> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id17f347d2> ;
        wp:source         <https://identifiers.org/ncbigene/5743> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id17f347d2> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/e25b9>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/e25b9> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:606564> , <https://identifiers.org/ncbigene/2099> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e25b9> .

<https://identifiers.org/pmc/PMC12448840>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC12448840" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4483> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC12448840> .

<https://identifiers.org/ncbigene/10000>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT3" ;
        dc:identifier       <https://identifiers.org/ncbigene/10000> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "10000" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e8651> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000117020> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10000> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A5K1VW74> , <https://identifiers.org/uniprot/Q9Y243> , <https://identifiers.org/uniprot/A0A7P0TB29> , <https://identifiers.org/uniprot/A0A5F9ZHA9> , <https://identifiers.org/uniprot/A0A7P0TBJ6> , <https://identifiers.org/uniprot/A0A7P0TB32> , <https://identifiers.org/uniprot/A0A5F9ZGZ4> , <https://identifiers.org/uniprot/A0A5F9ZGY0> , <https://identifiers.org/uniprot/A0A5F9ZHU3> , <https://identifiers.org/uniprot/A0A7P0T872> , <https://identifiers.org/uniprot/A0A7P0T8T9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0TB29> , <http://purl.uniprot.org/uniprot/Q9Y243> , <http://purl.uniprot.org/uniprot/A0A5F9ZHA9> , <http://purl.uniprot.org/uniprot/A0A5F9ZGY0> , <http://purl.uniprot.org/uniprot/A0A7P0T872> , <http://purl.uniprot.org/uniprot/A0A7P0TBJ6> , <http://purl.uniprot.org/uniprot/A0A7P0TB32> , <http://purl.uniprot.org/uniprot/A0A7P0T8T9> , <http://purl.uniprot.org/uniprot/A0A5K1VW74> , <http://purl.uniprot.org/uniprot/A0A5F9ZGZ4> , <http://purl.uniprot.org/uniprot/A0A5F9ZHU3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/10000> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/a8560>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/a8560> ;
        wp:participants   <https://identifiers.org/ncbigene/4893> , <https://identifiers.org/ncbigene/3265> , <https://identifiers.org/ncbigene/3845> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/a8560> .

<https://identifiers.org/wikipathways/WP4483_r134778>
        rdf:type               wp:Pathway , skos:Collection ;
        dc:identifier          <https://identifiers.org/wikipathways/WP4483> ;
        dc:source              "WikiPathways" ;
        dc:title               "Relationship between inflammation, COX-2 and EGFR"@en ;
        dcterms:description    "Arachidonic acid metabolic pathway can be activated by inflammation (stimulus). Arachidonic acid is released from membrane phospholipids by a phospholipase A2 (PLA-2) enzyme and converted to bioactive PGE-2 by COX-2. PGE2 induces transactivation of the EGFR by triggering Src and PGE2, an important regulator of CYP19A1 gene expression, stimulates CYP19A1 activity to increase localized estrogen 17-beta-estradiol (E2). The E2 binds to the classical ER to promote its dimerization and translocation to the nucleus where it modulates the expression of estrogen target genes (COX-2). The interaction of E2 with ER-alpha also activates signaling cascades that promote cell proliferation, such as the activation of c-Src tyrosine kinase (Src). Src activation stimulates a matrix metalloproteinase cascade that culminates in liberating the EGF. The free EGF ligand binds to EGFR family receptors that activate ERK signaling cascade. Cytosolic phospholipase A2 (cPLA) is a substrate for ERK and phosphorylation of cPLA (cPLAp), promoting its association with intracellular membranes such as those of the endoplasmic reticulum and mitochondria releasing lysophospholipids and arachidonic acid from these membranes. COX-2 catalyzes the conversion of arachidonic acid into PGE-2. \n\nThese key molecules and pathways that connect chronic inflammation with inflammation-associated oncogenic transformation could be targeted by drugs or natural products for novel preventive and therapeutic strategies for malignant mesothelioma." ;
        dcterms:identifier     "WP4483" ;
        dcterms:references     <https://identifiers.org/pubmed/23729401> ;
        cito:cites             <https://identifiers.org/pubmed/23729401> ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP4483_r134778> ;
        wp:ontologyTag         wp:Curation:ONTOX , wp:Curation:AnalysisCollection , obo:PW_0000460 ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000460 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4483&oldid=134778> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4483&oldid=134778> ;
        foaf:page              <http://www.wikipathways.org/instance/WP4483_r134778> .

<https://identifiers.org/ncbigene/1956>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "EGFR" ;
        dc:identifier       <https://identifiers.org/ncbigene/1956> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1956" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000146648> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1956> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EGFR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JYS6> , <https://identifiers.org/uniprot/A0A8V8TPW8> , <https://identifiers.org/uniprot/Q504U8> , <https://identifiers.org/uniprot/P00533> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/f2e05> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TPW8> , <http://purl.uniprot.org/uniprot/Q504U8> , <http://purl.uniprot.org/uniprot/C9JYS6> , <http://purl.uniprot.org/uniprot/P00533> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1956> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idd481f113>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/idd481f113> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:606564> , <https://identifiers.org/ncbigene/1588> ;
        wp:source         <https://identifiers.org/ncbigene/1588> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:606564> .

<https://identifiers.org/ncbigene/5290>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PI3KA" ;
        dc:identifier       <https://identifiers.org/ncbigene/5290> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5290" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c4a2d> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000121879> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5290> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A2R8Y2F6> , <https://identifiers.org/uniprot/A0A6Q8PGN9> , <https://identifiers.org/uniprot/A0A6Q8PGV1> , <https://identifiers.org/uniprot/C9JAM9> , <https://identifiers.org/uniprot/C9J951> , <https://identifiers.org/uniprot/P42336> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/dcd86> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A6Q8PGN9> , <http://purl.uniprot.org/uniprot/A0A6Q8PGV1> , <http://purl.uniprot.org/uniprot/P42336> , <http://purl.uniprot.org/uniprot/C9JAM9> , <http://purl.uniprot.org/uniprot/A0A2R8Y2F6> , <http://purl.uniprot.org/uniprot/C9J951> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5290> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id69510ebc>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/id69510ebc> ;
        wp:participants   <https://identifiers.org/ncbigene/80142> , <https://identifiers.org/chebi/CHEBI:15843> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:15843> ;
        wp:target         <https://identifiers.org/ncbigene/80142> .

<https://identifiers.org/ncbigene/5733>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PTGER3" ;
        dc:identifier       <https://identifiers.org/ncbigene/5733> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5733" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c6965> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000050628> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5733> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTGER3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0B4J204> , <https://identifiers.org/uniprot/P43115> , <https://identifiers.org/uniprot/O00325> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P43115> , <http://purl.uniprot.org/uniprot/A0A0B4J204> , <http://purl.uniprot.org/uniprot/O00325> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5733> .

<https://identifiers.org/ncbigene/5595>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ERK1" ;
        dc:identifier       <https://identifiers.org/ncbigene/5595> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5595" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/db1ad> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102882> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PQW4> , <https://identifiers.org/uniprot/H0YDH9> , <https://identifiers.org/uniprot/H0YEX6> , <https://identifiers.org/uniprot/B3KR49> , <https://identifiers.org/uniprot/E9PRH7> , <https://identifiers.org/uniprot/L7RXH5> , <https://identifiers.org/uniprot/E9PJF0> , <https://identifiers.org/uniprot/E9PBK7> , <https://identifiers.org/uniprot/P27361> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PBK7> , <http://purl.uniprot.org/uniprot/B3KR49> , <http://purl.uniprot.org/uniprot/L7RXH5> , <http://purl.uniprot.org/uniprot/H0YDH9> , <http://purl.uniprot.org/uniprot/E9PJF0> , <http://purl.uniprot.org/uniprot/E9PQW4> , <http://purl.uniprot.org/uniprot/P27361> , <http://purl.uniprot.org/uniprot/H0YEX6> , <http://purl.uniprot.org/uniprot/E9PRH7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5595> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/c6965>
        rdf:type          wp:Interaction , wp:Binding , wp:ComplexBinding ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/c6965> ;
        wp:participants   <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c6965> , <https://identifiers.org/ncbigene/5734> , <https://identifiers.org/ncbigene/5731> , <https://identifiers.org/ncbigene/5733> , <https://identifiers.org/ncbigene/5732> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b10f7>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/b10f7> ;
        wp:participants   <https://identifiers.org/ncbigene/2099> , <https://identifiers.org/chebi/CHEBI:606564> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b3a5a>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/b3a5a> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:606564> , <https://identifiers.org/ncbigene/2099> .

<https://identifiers.org/ncbigene/51365>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "cPLA" ;
        dc:identifier       <https://identifiers.org/ncbigene/51365> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "51365" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000144837> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/51365> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLA1A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G5E9W0> , <https://identifiers.org/uniprot/Q53H76> , <https://identifiers.org/uniprot/H7C4H1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/dac41> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H7C4H1> , <http://purl.uniprot.org/uniprot/G5E9W0> , <http://purl.uniprot.org/uniprot/Q53H76> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/51365> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/ida5958e07>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/ida5958e07> ;
        wp:participants   <https://identifiers.org/ncbiprotein/P01133> , <https://identifiers.org/ncbigene/4312> ;
        wp:source         <https://identifiers.org/ncbigene/4312> ;
        wp:target         <https://identifiers.org/ncbiprotein/P01133> .

<https://identifiers.org/chebi/CHEBI:606564>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "E2" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XEYBRNLFEZDVAW-ARSRFYASSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:606564> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:606564" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e25b9> , <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idd481f113> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id5fba6787> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b10f7> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b3a5a> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:606564> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/10039756> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XEYBRNLFEZDVAW-ARSRFYASSA-M> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11865423> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27225783> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/fe5c4> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/d33e3> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/f72e5> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/d0019> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/a5de1> ;
        owl:sameAs          <https://swisslipids.org/rdf/SLM_000000916> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:606564> .

<https://identifiers.org/ncbigene/5732>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PTGER2" ;
        dc:identifier       <https://identifiers.org/ncbigene/5732> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5732" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c6965> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000125384> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5732> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTGER2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P43116> , <https://identifiers.org/uniprot/G3V2Y6> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P43116> , <http://purl.uniprot.org/uniprot/G3V2Y6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5732> .

<https://identifiers.org/ncbigene/5594>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ERK2" ;
        dc:identifier       <https://identifiers.org/ncbigene/5594> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5594" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/db1ad> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5594> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q1HBJ4> , <https://identifiers.org/uniprot/P28482> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28482> , <http://purl.uniprot.org/uniprot/Q1HBJ4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5594> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4483&oldid=134778>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/e8651>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/e8651> ;
        wp:participants   <https://identifiers.org/ncbigene/10000> , <https://identifiers.org/ncbigene/208> , <https://identifiers.org/ncbigene/207> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e8651> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/a8560>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/a8560> ;
        wp:participants   <https://identifiers.org/ncbigene/4893> , <https://identifiers.org/ncbigene/3265> , <https://identifiers.org/ncbigene/3845> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/ncbigene/673>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "BRAF" ;
        dc:identifier       <https://identifiers.org/ncbigene/673> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "673" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000157764> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/673> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BRAF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C4S5> , <https://identifiers.org/uniprot/H7C5K3> , <https://identifiers.org/uniprot/A0A2R8Y679> , <https://identifiers.org/uniprot/A0A2R8Y8E0> , <https://identifiers.org/uniprot/P15056> , <https://identifiers.org/uniprot/H7C560> , <https://identifiers.org/uniprot/A0A2R8YES9> , <https://identifiers.org/uniprot/A0A2R8Y492> , <https://identifiers.org/uniprot/A0A2U3TZI2> , <https://identifiers.org/uniprot/A0A2R8YDP5> , <https://identifiers.org/uniprot/A0A2R8Y467> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/d23ee> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A2R8Y467> , <http://purl.uniprot.org/uniprot/A0A2R8Y8E0> , <http://purl.uniprot.org/uniprot/H7C560> , <http://purl.uniprot.org/uniprot/A0A2R8YDP5> , <http://purl.uniprot.org/uniprot/A0A2R8YES9> , <http://purl.uniprot.org/uniprot/P15056> , <http://purl.uniprot.org/uniprot/H7C4S5> , <http://purl.uniprot.org/uniprot/A0A2R8Y679> , <http://purl.uniprot.org/uniprot/H7C5K3> , <http://purl.uniprot.org/uniprot/A0A2R8Y492> , <http://purl.uniprot.org/uniprot/A0A2U3TZI2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/673> .

<https://identifiers.org/ncbigene/5294>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PI3KG" ;
        dc:identifier       <https://identifiers.org/ncbigene/5294> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5294" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c4a2d> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105851> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5294> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P48736> , <https://identifiers.org/uniprot/A0A024R720> , <https://identifiers.org/uniprot/E9PDN7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P48736> , <http://purl.uniprot.org/uniprot/A0A024R720> , <http://purl.uniprot.org/uniprot/E9PDN7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5294> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/db1ad>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/db1ad> ;
        wp:participants   <https://identifiers.org/ncbigene/5595> , <https://identifiers.org/ncbigene/5594> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/db1ad> .

<https://identifiers.org/wikipathways/WP4483>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4483_r134778> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c6965>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/c6965> ;
        wp:participants   <https://identifiers.org/ncbigene/5731> , <https://identifiers.org/ncbigene/5732> , <https://identifiers.org/ncbigene/5734> , <https://identifiers.org/ncbigene/5733> .

<https://identifiers.org/ncbigene/4312>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MMP1" ;
        dc:identifier       <https://identifiers.org/ncbigene/4312> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4312" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idfe1f5cfb> , <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/ida5958e07> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000196611> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4312> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MMP1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P03956> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/fc4d6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P03956> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4312> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/c4a2d>
        rdf:type          wp:Binding , wp:Interaction , wp:ComplexBinding ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/c4a2d> ;
        wp:participants   <https://identifiers.org/ncbigene/5293> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c4a2d> , <https://identifiers.org/ncbigene/5290> , <https://identifiers.org/ncbigene/5291> , <https://identifiers.org/ncbigene/5294> .

<https://identifiers.org/ncbigene/5731>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PTGER1" ;
        dc:identifier       <https://identifiers.org/ncbigene/5731> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5731" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c6965> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000160951> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5731> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTGER1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P34995> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P34995> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5731> .

<https://identifiers.org/ncbigene/4893>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NRAS" ;
        dc:identifier       <https://identifiers.org/ncbigene/4893> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4893" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/a8560> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000213281> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4893> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01111> , <https://identifiers.org/uniprot/Q5U091> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01111> , <http://purl.uniprot.org/uniprot/Q5U091> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4893> .

<https://identifiers.org/ncbigene/1588>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CYP19A1" ;
        dc:identifier       <https://identifiers.org/ncbigene/1588> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1588" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id5fba6787> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idd481f113> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137869> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1588> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP19A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E7EQ08> , <https://identifiers.org/uniprot/H0YK57> , <https://identifiers.org/uniprot/A0A024R5S8> , <https://identifiers.org/uniprot/H0YKN1> , <https://identifiers.org/uniprot/H0YNJ7> , <https://identifiers.org/uniprot/E9PGZ6> , <https://identifiers.org/uniprot/H0YLS2> , <https://identifiers.org/uniprot/H0YLP1> , <https://identifiers.org/uniprot/P11511> , <https://identifiers.org/uniprot/E7EPL6> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/b9e58> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E7EPL6> , <http://purl.uniprot.org/uniprot/E7EQ08> , <http://purl.uniprot.org/uniprot/A0A024R5S8> , <http://purl.uniprot.org/uniprot/E9PGZ6> , <http://purl.uniprot.org/uniprot/H0YK57> , <http://purl.uniprot.org/uniprot/H0YLS2> , <http://purl.uniprot.org/uniprot/H0YKN1> , <http://purl.uniprot.org/uniprot/H0YNJ7> , <http://purl.uniprot.org/uniprot/H0YLP1> , <http://purl.uniprot.org/uniprot/P11511> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1588> .

<https://identifiers.org/ncbigene/3845>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "KRAS" ;
        dc:identifier       <https://identifiers.org/ncbigene/3845> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "3845" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/a8560> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000133703> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3845> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KQ21> , <https://identifiers.org/uniprot/A0A8I5KYH6> , <https://identifiers.org/uniprot/P01116> , <https://identifiers.org/uniprot/A0A8I5KUB5> , <https://identifiers.org/uniprot/A0A8I5KXN3> , <https://identifiers.org/uniprot/A0A8I5KR86> , <https://identifiers.org/uniprot/A0A8I5KQU3> , <https://identifiers.org/uniprot/G3V4K2> , <https://identifiers.org/uniprot/A0A024RAV5> , <https://identifiers.org/uniprot/L7RSL8> , <https://identifiers.org/uniprot/G3V5T7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KYH6> , <http://purl.uniprot.org/uniprot/A0A8I5KR86> , <http://purl.uniprot.org/uniprot/A0A024RAV5> , <http://purl.uniprot.org/uniprot/A0A8I5KQU3> , <http://purl.uniprot.org/uniprot/G3V5T7> , <http://purl.uniprot.org/uniprot/L7RSL8> , <http://purl.uniprot.org/uniprot/G3V4K2> , <http://purl.uniprot.org/uniprot/A0A8I5KQ21> , <http://purl.uniprot.org/uniprot/A0A8I5KXN3> , <http://purl.uniprot.org/uniprot/P01116> , <http://purl.uniprot.org/uniprot/A0A8I5KUB5> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/3845> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4483&oldid=134778>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e25b9>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/e25b9> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:606564> , <https://identifiers.org/ncbigene/2099> .

<https://identifiers.org/ncbigene/5293>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PI3KD" ;
        dc:identifier       <https://identifiers.org/ncbigene/5293> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5293" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c4a2d> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171608> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5293> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CD> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TML5> , <https://identifiers.org/uniprot/B7ZM44> , <https://identifiers.org/uniprot/O00329> , <https://identifiers.org/uniprot/A0A8V8TMM0> , <https://identifiers.org/uniprot/A0A2K8FKV1> , <https://identifiers.org/uniprot/A0A8V8TNW9> , <https://identifiers.org/uniprot/A0A8V8TNP1> , <https://identifiers.org/uniprot/F8W9P4> , <https://identifiers.org/uniprot/A0A8V8TM62> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F8W9P4> , <http://purl.uniprot.org/uniprot/O00329> , <http://purl.uniprot.org/uniprot/A0A8V8TMM0> , <http://purl.uniprot.org/uniprot/A0A8V8TML5> , <http://purl.uniprot.org/uniprot/A0A2K8FKV1> , <http://purl.uniprot.org/uniprot/A0A8V8TM62> , <http://purl.uniprot.org/uniprot/B7ZM44> , <http://purl.uniprot.org/uniprot/A0A8V8TNW9> , <http://purl.uniprot.org/uniprot/A0A8V8TNP1> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5293> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e8651>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/e8651> ;
        wp:participants   <https://identifiers.org/ncbigene/10000> , <https://identifiers.org/ncbigene/208> , <https://identifiers.org/ncbigene/207> .

<https://identifiers.org/ncbigene/5743>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "COX-2" ;
        dc:identifier       <https://identifiers.org/ncbigene/5743> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5743" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idb444734d> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000073756> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5743> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTGS2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P35354> , <https://identifiers.org/uniprot/Q6ZYK7> , <https://identifiers.org/uniprot/A0A7P0T828> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/ef113> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0T828> , <http://purl.uniprot.org/uniprot/Q6ZYK7> , <http://purl.uniprot.org/uniprot/P35354> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5743> .

<https://identifiers.org/pubmed/23729401>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "23729401" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/23729401> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/b3a5a>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/b3a5a> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:606564> , <https://identifiers.org/ncbigene/2099> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b3a5a> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id5fba6787>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/id5fba6787> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:606564> , <https://identifiers.org/ncbigene/1588> ;
        wp:source         <https://identifiers.org/ncbigene/1588> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:606564> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/db1ad>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/db1ad> ;
        wp:participants   <https://identifiers.org/ncbigene/5595> , <https://identifiers.org/ncbigene/5594> .

<https://identifiers.org/ncbigene/6714>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Src" ;
        dc:identifier       <https://identifiers.org/ncbigene/6714> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6714" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idfe1f5cfb> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000197122> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6714> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SRC> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KYU4> , <https://identifiers.org/uniprot/P12931> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/fd3c8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P12931> , <http://purl.uniprot.org/uniprot/A0A8I5KYU4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6714> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/c4a2d>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/c4a2d> ;
        wp:participants   <https://identifiers.org/ncbigene/5294> , <https://identifiers.org/ncbigene/5293> , <https://identifiers.org/ncbigene/5291> , <https://identifiers.org/ncbigene/5290> .

<https://identifiers.org/ncbigene/208>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT2" ;
        dc:identifier       <https://identifiers.org/ncbigene/208> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "208" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/e8651> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105221> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/208> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A8MX96> , <https://identifiers.org/uniprot/M0R275> , <https://identifiers.org/uniprot/J3KSY8> , <https://identifiers.org/uniprot/P31751> , <https://identifiers.org/uniprot/J3QLS6> , <https://identifiers.org/uniprot/J3QKW1> , <https://identifiers.org/uniprot/E7EVP8> , <https://identifiers.org/uniprot/M0QZW8> , <https://identifiers.org/uniprot/J3KRI8> , <https://identifiers.org/uniprot/J3KT31> , <https://identifiers.org/uniprot/M0R283> , <https://identifiers.org/uniprot/C9JIJ1> , <https://identifiers.org/uniprot/A0A5F9ZHJ8> , <https://identifiers.org/uniprot/M0QZK3> , <https://identifiers.org/uniprot/C9JHS6> , <https://identifiers.org/uniprot/J3QL45> , <https://identifiers.org/uniprot/A0A0A0MRF1> , <https://identifiers.org/uniprot/C9JIF6> , <https://identifiers.org/uniprot/J3KTC6> , <https://identifiers.org/uniprot/C9J258> , <https://identifiers.org/uniprot/M0R0P9> , <https://identifiers.org/uniprot/A0A1B0GXA2> , <https://identifiers.org/uniprot/C9JC83> , <https://identifiers.org/uniprot/J3KTP4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3KRI8> , <http://purl.uniprot.org/uniprot/J3KT31> , <http://purl.uniprot.org/uniprot/C9JHS6> , <http://purl.uniprot.org/uniprot/C9J258> , <http://purl.uniprot.org/uniprot/A0A5F9ZHJ8> , <http://purl.uniprot.org/uniprot/A0A0A0MRF1> , <http://purl.uniprot.org/uniprot/C9JC83> , <http://purl.uniprot.org/uniprot/J3KSY8> , <http://purl.uniprot.org/uniprot/M0R275> , <http://purl.uniprot.org/uniprot/M0R0P9> , <http://purl.uniprot.org/uniprot/P31751> , <http://purl.uniprot.org/uniprot/C9JIJ1> , <http://purl.uniprot.org/uniprot/J3QL45> , <http://purl.uniprot.org/uniprot/J3KTP4> , <http://purl.uniprot.org/uniprot/A0A1B0GXA2> , <http://purl.uniprot.org/uniprot/A8MX96> , <http://purl.uniprot.org/uniprot/J3KTC6> , <http://purl.uniprot.org/uniprot/J3QLS6> , <http://purl.uniprot.org/uniprot/M0QZW8> , <http://purl.uniprot.org/uniprot/C9JIF6> , <http://purl.uniprot.org/uniprot/J3QKW1> , <http://purl.uniprot.org/uniprot/M0QZK3> , <http://purl.uniprot.org/uniprot/M0R283> , <http://purl.uniprot.org/uniprot/E7EVP8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/208> .

<https://identifiers.org/ncbigene/3265>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "HRAS" ;
        dc:identifier       <https://identifiers.org/ncbigene/3265> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "3265" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/a8560> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000174775> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3265> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A804HKM6> , <https://identifiers.org/uniprot/A0A804HJ06> , <https://identifiers.org/uniprot/X5D945> , <https://identifiers.org/uniprot/P01112> , <https://identifiers.org/uniprot/A0A8C8MQR2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/null> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8C8MQR2> , <http://purl.uniprot.org/uniprot/X5D945> , <http://purl.uniprot.org/uniprot/P01112> , <http://purl.uniprot.org/uniprot/A0A804HJ06> , <http://purl.uniprot.org/uniprot/A0A804HKM6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/3265> .

<https://identifiers.org/chebi/CHEBI:15843>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Arachidonic acid" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/YZXBAPSDXZZRGB-DOFZRALJSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15843> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:15843" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4483_r134778> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id69510ebc> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id17f347d2> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15843> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/392692> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001043> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/YZXBAPSDXZZRGB-DOFZRALJSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00219> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMFA01030001> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID444899> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q407699> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/f4bbf> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/d62cc> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMFA01030001> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15843> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/ComplexBinding/b10f7>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Group/b10f7> ;
        wp:participants   <https://identifiers.org/ncbigene/2099> , <https://identifiers.org/chebi/CHEBI:606564> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Complex/b10f7> .

<http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/idfe1f5cfb>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4483_r134778/Interaction/idfe1f5cfb> ;
        wp:participants   <https://identifiers.org/ncbigene/4312> , <https://identifiers.org/ncbigene/6714> ;
        wp:source         <https://identifiers.org/ncbigene/6714> ;
        wp:target         <https://identifiers.org/ncbigene/4312> .

<https://identifiers.org/ncbigene/80142>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PGE2" ;
        dc:identifier       <https://identifiers.org/ncbigene/80142> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "80142" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id69510ebc> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/WP/Interaction/id17f347d2> , <https://identifiers.org/wikipathways/WP4483_r134778> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000148334> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/80142> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTGES2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/X6RJ95> , <https://identifiers.org/uniprot/A0A7I2V308> , <https://identifiers.org/uniprot/A0A7I2V5T7> , <https://identifiers.org/uniprot/Q9H7Z7> , <https://identifiers.org/uniprot/A0A7I2V4L3> , <https://identifiers.org/uniprot/A0A7I2YQ70> , <https://identifiers.org/uniprot/A6NHH0> , <https://identifiers.org/uniprot/A0A7I2V5X6> , <https://identifiers.org/uniprot/A0A7I2V460> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/d0b06> , <http://rdf.wikipathways.org/Pathway/WP4483_r134778/DataNode/a9129> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A6NHH0> , <http://purl.uniprot.org/uniprot/A0A7I2YQ70> , <http://purl.uniprot.org/uniprot/A0A7I2V460> , <http://purl.uniprot.org/uniprot/Q9H7Z7> , <http://purl.uniprot.org/uniprot/A0A7I2V4L3> , <http://purl.uniprot.org/uniprot/A0A7I2V308> , <http://purl.uniprot.org/uniprot/A0A7I2V5X6> , <http://purl.uniprot.org/uniprot/A0A7I2V5T7> , <http://purl.uniprot.org/uniprot/X6RJ95> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/80142> .
