@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000149782>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCB3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000149782> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000149782" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000149782> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5331> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCB3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q01970> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030581> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/ec30e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q01970> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000149782> .

<https://identifiers.org/ensembl/ENSG00000197943>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCG2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000197943> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000197943" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000197943> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5336> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCG2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TL51> , <https://identifiers.org/uniprot/H3BPZ3> , <https://identifiers.org/uniprot/A0A8V8TMP2> , <https://identifiers.org/uniprot/A0A8V8TLH5> , <https://identifiers.org/uniprot/P16885> , <https://identifiers.org/uniprot/A0A8V8TL55> , <https://identifiers.org/uniprot/A0A8V8TLG6> , <https://identifiers.org/uniprot/A0A8V8TMG4> , <https://identifiers.org/uniprot/A0A8V8TMQ0> , <https://identifiers.org/uniprot/H3BMT7> , <https://identifiers.org/uniprot/A0A8V8TL29> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030586> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/b5b09> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TMG4> , <http://purl.uniprot.org/uniprot/A0A8V8TL29> , <http://purl.uniprot.org/uniprot/A0A8V8TL55> , <http://purl.uniprot.org/uniprot/H3BMT7> , <http://purl.uniprot.org/uniprot/A0A8V8TMP2> , <http://purl.uniprot.org/uniprot/H3BPZ3> , <http://purl.uniprot.org/uniprot/A0A8V8TL51> , <http://purl.uniprot.org/uniprot/A0A8V8TLH5> , <http://purl.uniprot.org/uniprot/A0A8V8TMQ0> , <http://purl.uniprot.org/uniprot/P16885> , <http://purl.uniprot.org/uniprot/A0A8V8TLG6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000197943> .

<https://identifiers.org/pmc/PMC8912249>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC8912249" ;
        cito:cites          <https://identifiers.org/wikipathways/WP3958> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC8912249> .

<https://identifiers.org/ensembl/ENSG00000088256>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GNA11" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000088256> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000088256" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000088256> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2767> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GNA11> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P29992> , <https://identifiers.org/uniprot/K7EL62> , <https://identifiers.org/uniprot/A0A087WVZ3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18026212> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/de8cc> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P29992> , <http://purl.uniprot.org/uniprot/K7EL62> , <http://purl.uniprot.org/uniprot/A0A087WVZ3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000088256> .

<https://identifiers.org/ensembl/ENSG00000187091>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCD1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000187091> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000187091" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000187091> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5333> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCD1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P51178> , <https://identifiers.org/uniprot/A0A384MR47> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030583> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/ce8d6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A384MR47> , <http://purl.uniprot.org/uniprot/P51178> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000187091> .

<http://rdf.wikipathways.org/Pathway/WP3958_r140057/WP/Interaction/idd9c2dd2>
        rdf:type            wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        dcterms:references  <https://identifiers.org/pubmed/23631851> , <https://identifiers.org/pubmed/24051395> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/Interaction/idd9c2dd2> ;
        wp:participants     <https://identifiers.org/ensembl/ENSG00000008710> , <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:target           <https://identifiers.org/ensembl/ENSG00000008710> .

<https://identifiers.org/wikipathways/WP3958>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP3958_r140057> .

<https://identifiers.org/pmc/PMC9154116>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC9154116" ;
        cito:cites          <https://identifiers.org/wikipathways/WP3958> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9154116> .

<https://identifiers.org/ensembl/ENSG00000138193>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PLCE1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000138193> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000138193" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000138193> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/51196> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCE1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A6Q8PGT4> , <https://identifiers.org/uniprot/A0A8I5KQ92> , <https://identifiers.org/uniprot/B7ZM61> , <https://identifiers.org/uniprot/A0A8I5KXT2> , <https://identifiers.org/uniprot/Q9P212> , <https://identifiers.org/uniprot/A0A6Q8PFG0> , <https://identifiers.org/uniprot/A0A8I5KV08> , <https://identifiers.org/uniprot/A0A6Q8PHN3> , <https://identifiers.org/uniprot/A0A6Q8PHP9> , <https://identifiers.org/uniprot/A0A8I5KVG7> , <https://identifiers.org/uniprot/A0A7I2PPM5> , <https://identifiers.org/uniprot/A0A6Q8PH04> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18040087> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/ea286> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KXT2> , <http://purl.uniprot.org/uniprot/A0A6Q8PHP9> , <http://purl.uniprot.org/uniprot/Q9P212> , <http://purl.uniprot.org/uniprot/A0A6Q8PH04> , <http://purl.uniprot.org/uniprot/A0A6Q8PGT4> , <http://purl.uniprot.org/uniprot/A0A7I2PPM5> , <http://purl.uniprot.org/uniprot/A0A8I5KQ92> , <http://purl.uniprot.org/uniprot/A0A6Q8PFG0> , <http://purl.uniprot.org/uniprot/B7ZM61> , <http://purl.uniprot.org/uniprot/A0A6Q8PHN3> , <http://purl.uniprot.org/uniprot/A0A8I5KVG7> , <http://purl.uniprot.org/uniprot/A0A8I5KV08> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000138193> .

<https://identifiers.org/ensembl/ENSG00000161714>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PLCD3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000161714> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000161714" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000161714> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/113026> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCD3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5GXC1> , <https://identifiers.org/uniprot/Q8N3E9> , <https://identifiers.org/uniprot/H0YGF8> , <https://identifiers.org/uniprot/K7EQF2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18048885> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/b3675> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q8N3E9> , <http://purl.uniprot.org/uniprot/F5GXC1> , <http://purl.uniprot.org/uniprot/H0YGF8> , <http://purl.uniprot.org/uniprot/K7EQF2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000161714> .

<https://identifiers.org/ensembl/ENSG00000115896>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCL1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000115896> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000115896" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115896> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5334> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCL1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q15111> , <https://identifiers.org/uniprot/F8WAR2> , <https://identifiers.org/uniprot/H3BUD4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030584> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/eb2be> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F8WAR2> , <http://purl.uniprot.org/uniprot/Q15111> , <http://purl.uniprot.org/uniprot/H3BUD4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000115896> .

<https://identifiers.org/ensembl/ENSG00000008710>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PKD1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000008710> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000008710" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3958_r140057/WP/Interaction/idd9c2dd2> , <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000008710> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5310> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PKD1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BTE0> , <https://identifiers.org/uniprot/H3BV77> , <https://identifiers.org/uniprot/H3BSE8> , <https://identifiers.org/uniprot/I3L4N0> , <https://identifiers.org/uniprot/P98161> , <https://identifiers.org/uniprot/H3BQF4> , <https://identifiers.org/uniprot/H3BSE9> , <https://identifiers.org/uniprot/H3BTG3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14914567> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/c032b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H3BQF4> , <http://purl.uniprot.org/uniprot/H3BTE0> , <http://purl.uniprot.org/uniprot/P98161> , <http://purl.uniprot.org/uniprot/H3BV77> , <http://purl.uniprot.org/uniprot/H3BTG3> , <http://purl.uniprot.org/uniprot/H3BSE9> , <http://purl.uniprot.org/uniprot/H3BSE8> , <http://purl.uniprot.org/uniprot/I3L4N0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000008710> .

<http://rdf.wikipathways.org/Pathway/WP3958_r140057/WP/Interaction/id37a0d4b2>
        rdf:type            wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        dcterms:references  <https://identifiers.org/pubmed/23631851> , <https://identifiers.org/pubmed/24051395> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/Interaction/id37a0d4b2> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:29108> , <https://identifiers.org/ensembl/ENSG00000096433> ;
        wp:source           <https://identifiers.org/ensembl/ENSG00000096433> ;
        wp:target           <https://identifiers.org/chebi/CHEBI:29108> .

<https://identifiers.org/chebi/CHEBI:29108>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ca²⁺" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:29108> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:29108" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3958_r140057/WP/Interaction/id37a0d4b2> , <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29108> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/266> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000464> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00076> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID271> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q23905776> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/d72fe> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29108> .

<https://identifiers.org/ensembl/ENSG00000124181>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCG1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000124181> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000124181" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000124181> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5335> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCG1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/V9GY63> , <https://identifiers.org/uniprot/M0QX77> , <https://identifiers.org/uniprot/V9GYH5> , <https://identifiers.org/uniprot/P19174> , <https://identifiers.org/uniprot/A0A0D9SEK2> , <https://identifiers.org/uniprot/V9GY71> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030585> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/fac49> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/V9GYH5> , <http://purl.uniprot.org/uniprot/V9GY71> , <http://purl.uniprot.org/uniprot/A0A0D9SEK2> , <http://purl.uniprot.org/uniprot/P19174> , <http://purl.uniprot.org/uniprot/M0QX77> , <http://purl.uniprot.org/uniprot/V9GY63> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000124181> .

<https://identifiers.org/chebi/CHEBI:18035>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "DAG" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:18035> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:18035" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> , <http://rdf.wikipathways.org/Pathway/WP3958_r140057/WP/Interaction/idd9c2dd2> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00165> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMGL0201> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q161466> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/b2db0> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMGL0201> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18035> .

<https://identifiers.org/ensembl/ENSG00000137841>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCB2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000137841> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000137841" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3958_r140057> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137841> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5330> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9BVT6> , <https://identifiers.org/uniprot/H0YKR9> , <https://identifiers.org/uniprot/Q00722> , <https://identifiers.org/uniprot/H0YNI4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030580> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3958_r140057/DataNode/eb68c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q00722> , <http://purl.uniprot.org/uniprot/H0YKR9> , <http://purl.uniprot.org/uniprot/H0YNI4> , <http://purl.uniprot.org/uniprot/Q9BVT6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000137841> .

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<https://identifiers.org/wikipathways/WP3958_r140057>
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        dc:title                "GPR40 role in insulin secretion"@en ;
        dcterms:description     "G-protein-coupled receptor GPR40 (also known as Free fatty acid receptor 1, FFAR1) is a seven trans-membrane domain receptor which is predominantly expressed in pancreatic beta cells. It plays an essential role in fatty acid amplification of glucose-induced insulin secretion. GPR40 agonists are in second phase of preclinical trials for treatment of diabetes because of their role in improved glucose control. \n \nBinding of free fatty acids to GPR40 initiates a downstream signaling cascade which involves activation of a transducer protein, guanine nucleotide-binding protein subunit alpha-11 (GNA11). Next, phospholipase C (PLC) hormone is activated.  This hydrolyzes membrane phospholipids such as phosphatidylinositol-4-5-biphosphate into second messenger molecules inositol-1-4-5-triphosphate (IP3) and diacylglycerol (DAG). \n\nIP3 initiates calcium efflux from endoplasmic reticulum and increase intracellular calcium concentration.  Increased intracellular calcium concentration is involved in activating the insulin exocytosis machinery. DAG on the other hand activates PKD1. PKD1 initiates F-actin remodeling and supports the second phase of insulin exocytosis." ;
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<https://identifiers.org/ensembl/ENSG00000139151>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PLCZ1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000139151> ;
        dc:source           "Ensembl" ;
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        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000139151> ;
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        foaf:page           <https://www.ensembl.org/id/ENSG00000139151> .

<https://identifiers.org/ensembl/ENSG00000126266>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "GPR40" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000126266> ;
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<https://identifiers.org/ensembl/ENSG00000114805>
        rdf:type            wp:DataNode , wp:GeneProduct ;
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obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/chebi/CHEBI:16595>
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        dc:source           "ChEBI" ;
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        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16595> ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16595> .

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        rdf:type        foaf:Image ;
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<https://identifiers.org/pubmed/23631851>
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<https://identifiers.org/pubmed/24051395>
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<https://identifiers.org/ensembl/ENSG00000182621>
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        foaf:page           <https://www.ensembl.org/id/ENSG00000182621> .
