@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idd8cb5782>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idd8cb5782> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000116106> , <https://identifiers.org/ensembl/ENSG00000188095> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000188095> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000116106> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id9c98b82e>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id9c98b82e> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000149922> , <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000149922> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id96bcac66>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id96bcac66> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000114315> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000114315> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000114315> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idc4fa6cb7>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idc4fa6cb7> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000154342> .

<https://identifiers.org/ensembl/ENSG00000198719>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "DLL1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198719> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198719" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2d1ddc5c> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idfc8bc572> , <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idafe51d16> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198719> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/28514> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DLL1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0D9SF76> , <https://identifiers.org/uniprot/A0A384P5C6> , <https://identifiers.org/uniprot/O00548> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/d8973> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/f4710> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0D9SF76> , <http://purl.uniprot.org/uniprot/A0A384P5C6> , <http://purl.uniprot.org/uniprot/O00548> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198719> .

<https://identifiers.org/ensembl/ENSG00000106003>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "LFNG" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000106003> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000106003" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2e4fdeec> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2e7833e1> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id16cc8e0> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id3777b293> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000106003> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3955> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/LFNG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q8NES3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18028520> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/e7a60> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q8NES3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000106003> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id7d9535d0>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id7d9535d0> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000188095> , <https://identifiers.org/ncbigene/4851> ;
        wp:source         <https://identifiers.org/ncbigene/4851> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000188095> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idf9ba1782>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idf9ba1782> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000148400> , <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000148400> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP2854&oldid=141756>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2e4fdeec>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id2e4fdeec> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000106003> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000106003> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id9b749d6d>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id9b749d6d> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000154342> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idbfd493dd>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idbfd493dd> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000179111> , <https://identifiers.org/ncbigene/4851> ;
        wp:source         <https://identifiers.org/ncbigene/4851> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000179111> .

<https://identifiers.org/ensembl/ENSG00000203877>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RIPPLY2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000203877> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000203877" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idcc767638> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/ida2964802> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id8d07267b> , <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000203877> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/134701> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RIPPLY2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5TAB7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18050526> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/bb2e5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5TAB7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000203877> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id20315a91>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id20315a91> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000107831> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id3777b293>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id3777b293> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000106003> , <https://identifiers.org/ncbigene/4851> ;
        wp:source         <https://identifiers.org/ncbigene/4851> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000106003> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50>
        rdf:type          wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id1cd12f50> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id9602c9d1> ;
        wp:participants   <https://identifiers.org/ncbigene/4851> , <https://identifiers.org/ensembl/ENSG00000148400> , <https://identifiers.org/ensembl/ENSG00000198719> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000198719> , <https://identifiers.org/ensembl/ENSG00000148400> ;
        wp:target         <https://identifiers.org/ncbigene/4851> .

<https://identifiers.org/ensembl/ENSG00000148400>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NOTCH1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000148400> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000148400" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idf9ba1782> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id6c4a9b88> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> , <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000148400> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4851> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NOTCH1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7P0T9V1> , <https://identifiers.org/uniprot/A0A7P0Z4H9> , <https://identifiers.org/uniprot/A0A7P0TBG2> , <https://identifiers.org/uniprot/A0A7P0TB20> , <https://identifiers.org/uniprot/A0A7P0T8U6> , <https://identifiers.org/uniprot/A0A7P0TA56> , <https://identifiers.org/uniprot/P46531> , <https://identifiers.org/uniprot/A0A7P0TAK8> , <https://identifiers.org/uniprot/A0A7P0T8W1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18252685> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/a24b5> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/cf313> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P46531> , <http://purl.uniprot.org/uniprot/A0A7P0TB20> , <http://purl.uniprot.org/uniprot/A0A7P0TAK8> , <http://purl.uniprot.org/uniprot/A0A7P0TBG2> , <http://purl.uniprot.org/uniprot/A0A7P0T9V1> , <http://purl.uniprot.org/uniprot/A0A7P0TA56> , <http://purl.uniprot.org/uniprot/A0A7P0T8U6> , <http://purl.uniprot.org/uniprot/A0A7P0T8W1> , <http://purl.uniprot.org/uniprot/A0A7P0Z4H9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000148400> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/ida2964802>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/ida2964802> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000188095> , <https://identifiers.org/ensembl/ENSG00000203877> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000203877> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000188095> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idafe51d16>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idafe51d16> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000198719> , <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000198719> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2d1ddc5c>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id2d1ddc5c> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000198719> , <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000198719> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/pubmed/22761566>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "22761566" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2854_r141756> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/22761566> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id16cc8e0>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id16cc8e0> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000106003> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000106003> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> .

<https://identifiers.org/ensembl/ENSG00000154342>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "WNT3A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000154342> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000154342" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idfc8bc572> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id9b749d6d> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idc4fa6cb7> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idf9ba1782> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id6c4a9b88> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id9c98b82e> , <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/89780> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/WNT3A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P56704> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18048098> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/c5d2f> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/bef68> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P56704> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000154342> .

<https://identifiers.org/ensembl/ENSG00000114315>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "HES1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000114315> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000114315" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2a4d9be6> , <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id96bcac66> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000114315> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3280> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HES1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q14469> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18027301> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/eae0c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q14469> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000114315> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/iddc90ec24>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/iddc90ec24> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000188095> , <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000188095> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id8d07267b>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id8d07267b> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000203877> , <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000203877> .

<https://identifiers.org/ensembl/ENSG00000188095>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MESP2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000188095> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000188095" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/ida2964802> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idd8cb5782> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id7d9535d0> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/iddc90ec24> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idcc767638> , <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/ideab33fe> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000188095> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/145873> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MESP2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q0VG99> , <https://identifiers.org/uniprot/H0YKZ5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18051421> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/d39d8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H0YKZ5> , <http://purl.uniprot.org/uniprot/Q0VG99> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000188095> .

<https://identifiers.org/ensembl/ENSG00000116106>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "EPHA4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000116106> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000116106" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idd8cb5782> , <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000116106> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2043> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EPHA4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JIX8> , <https://identifiers.org/uniprot/H7C1N8> , <https://identifiers.org/uniprot/C9JFX5> , <https://identifiers.org/uniprot/H7C2W7> , <https://identifiers.org/uniprot/C9JEM6> , <https://identifiers.org/uniprot/A1MA61> , <https://identifiers.org/uniprot/F5GZZ5> , <https://identifiers.org/uniprot/P54764> , <https://identifiers.org/uniprot/E9PG71> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18250397> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/ea522> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PG71> , <http://purl.uniprot.org/uniprot/C9JIX8> , <http://purl.uniprot.org/uniprot/C9JFX5> , <http://purl.uniprot.org/uniprot/A1MA61> , <http://purl.uniprot.org/uniprot/F5GZZ5> , <http://purl.uniprot.org/uniprot/C9JEM6> , <http://purl.uniprot.org/uniprot/H7C2W7> , <http://purl.uniprot.org/uniprot/H7C1N8> , <http://purl.uniprot.org/uniprot/P54764> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000116106> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/ideab33fe>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/ideab33fe> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000188095> , <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000188095> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id139ec6a6>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id139ec6a6> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000107831> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2e7833e1>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id2e7833e1> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000106003> , <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000106003> .

<https://identifiers.org/ncbigene/4851>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NICD" ;
        dc:identifier       <https://identifiers.org/ncbigene/4851> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4851" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id1cd12f50> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2a4d9be6> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id3777b293> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idbfd493dd> , <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id7d9535d0> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000148400> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4851> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NOTCH1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7P0Z4H9> , <https://identifiers.org/uniprot/P46531> , <https://identifiers.org/uniprot/A0A7P0TAK8> , <https://identifiers.org/uniprot/A0A7P0TBG2> , <https://identifiers.org/uniprot/A0A7P0T8U6> , <https://identifiers.org/uniprot/A0A7P0TA56> , <https://identifiers.org/uniprot/A0A7P0T9V1> , <https://identifiers.org/uniprot/A0A7P0T8W1> , <https://identifiers.org/uniprot/A0A7P0TB20> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/d6e0b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0TA56> , <http://purl.uniprot.org/uniprot/A0A7P0T8U6> , <http://purl.uniprot.org/uniprot/A0A7P0TBG2> , <http://purl.uniprot.org/uniprot/A0A7P0TB20> , <http://purl.uniprot.org/uniprot/A0A7P0Z4H9> , <http://purl.uniprot.org/uniprot/A0A7P0T9V1> , <http://purl.uniprot.org/uniprot/A0A7P0T8W1> , <http://purl.uniprot.org/uniprot/P46531> , <http://purl.uniprot.org/uniprot/A0A7P0TAK8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4851> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id63e5ba7d>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id63e5ba7d> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000179111> .

<https://identifiers.org/ensembl/ENSG00000179111>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "HES7" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000179111> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000179111" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2d1ddc5c> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idbfd493dd> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id63e5ba7d> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2e7833e1> , <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000179111> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/84667> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HES7> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3KSH6> , <https://identifiers.org/uniprot/Q9BYE0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18047711> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/c11f9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9BYE0> , <http://purl.uniprot.org/uniprot/J3KSH6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000179111> .

<https://identifiers.org/ensembl/ENSG00000107831>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FGF8" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000107831> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000107831" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id139ec6a6> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/iddc90ec24> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idc151bef8> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id20315a91> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2253> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FGF8> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P55075> , <https://identifiers.org/uniprot/R4GMQ3> , <https://identifiers.org/uniprot/A0A087X1S5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17927891> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/eb1fd> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/cbb2f> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/bd6ad> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087X1S5> , <http://purl.uniprot.org/uniprot/R4GMQ3> , <http://purl.uniprot.org/uniprot/P55075> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000107831> .

<https://identifiers.org/wikipathways/WP2854>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP2854_r141756> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id6c4a9b88>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id6c4a9b88> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000148400> , <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000148400> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idc151bef8>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idc151bef8> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000107831> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000107831> .

<https://identifiers.org/ensembl/ENSG00000149922>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TBX6" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000149922> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000149922" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idafe51d16> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id9c98b82e> , <https://identifiers.org/wikipathways/WP2854_r141756> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id8d07267b> , <http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/ideab33fe> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000149922> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6911> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TBX6> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O95947> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031854> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2854_r141756/DataNode/ca8ee> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O95947> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000149922> .

<https://identifiers.org/wikipathways/WP2854_r141756>
        rdf:type               wp:Pathway , skos:Collection ;
        dc:identifier          <https://identifiers.org/wikipathways/WP2854> ;
        dc:source              "WikiPathways" ;
        dc:title               "Gene regulatory network modeling somitogenesis "@en ;
        dcterms:description    "Reaction scheme of the proposed gene regulatory network (GRN).\n\nThe scheme details the full GRN for one cell and part of a neighboring cell for those reactions that involve ligand-receptor interactions like in Delta-Notch signaling or input from the Fgf8 or Wnt3a signal transduction pathways. Color-coded circular areas for each gene symbolize mRNA and protein. For fast changing gene products the transport of mRNA or protein between cytoplasm and nucleus or between cytoplasm and membrane is explicitly simulated, which is indicated by dividing each half-area of the circle again. Regulatory interactions are shown as activating or repressing arrows. Broken lines indicate that the interaction is simulated only in an even more course-grained manner than the other gene regulatory reactions. NICD, which originates through cleavage reactions following DLL1 ligand binding to the NOTCH1 receptor, was assigned a separate symbol to clarify that only the intracellular domain of the Notch receptor acts in the nucleus as a transcription (co)-factor. The (weak) modulating action of LFNG on D/N signaling is shown as dashed lines - (red for the case of inhibiting action, green for the case of a positive effect on the D/N reaction rate.) Arrows pointing to the symbol for the empty set designate decay reactions of a species. We suppressed them for all species' decays except for those decay rates that we assume as controlled by signal transduction pathways. This applies also to the removal of DLL1 and NOTCH1 from the membrane after their binding, resulting in NOTCH1 cleavage and NICD split-off.\n\nProteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2854)." ;
        dcterms:identifier     "WP2854" ;
        dcterms:references     <https://identifiers.org/pubmed/22761566> ;
        cito:cites             <https://identifiers.org/pubmed/22761566> ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP2854_r141756> ;
        wp:ontologyTag         wp:Curation:ONTOX , obo:PW_0000004 , wp:Curation:AnalysisCollection ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000004 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP2854&oldid=141756> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP2854&oldid=141756> ;
        foaf:page              <http://www.wikipathways.org/instance/WP2854_r141756> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idcc767638>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idcc767638> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000203877> , <https://identifiers.org/ensembl/ENSG00000188095> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000188095> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000203877> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/id2a4d9be6>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/id2a4d9be6> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000114315> , <https://identifiers.org/ncbigene/4851> ;
        wp:source         <https://identifiers.org/ncbigene/4851> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000114315> .

<http://rdf.wikipathways.org/Pathway/WP2854_r141756/WP/Interaction/idfc8bc572>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2854_r141756> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2854_r141756/Interaction/idfc8bc572> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000198719> , <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154342> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000198719> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP2854&oldid=141756>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .
