@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/chebi/CHEBI:18035>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "DAG" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:18035> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:18035" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00165> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMGL0201> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q161466> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a8065> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMGL0201> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18035> .

<https://identifiers.org/ensembl/ENSG00000100030>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000100030> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000100030" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5594> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q1HBJ4> , <https://identifiers.org/uniprot/P28482> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15317730> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f96f7> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28482> , <http://purl.uniprot.org/uniprot/Q1HBJ4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000100030> .

<https://identifiers.org/hmdb/HMDB0249821>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "ceritinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/VERWOWGGCGHDQE-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0249821> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0249821" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/38375734> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:78432> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/29315053> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0249821> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/VERWOWGGCGHDQE-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID57379345> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q21011233> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a8e8c> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0249821> .

<https://identifiers.org/ensembl/ENSG00000130222>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "GADD45G" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000130222> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000130222" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130222> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10912> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GADD45G> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O95257> , <https://identifiers.org/uniprot/Q5VZ88> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18035942> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c8ba4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5VZ88> , <http://purl.uniprot.org/uniprot/O95257> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000130222> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idc5593e8>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/idc5593e8> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000133703> , <https://identifiers.org/hgnc.symbol/VEGFR2> ;
        wp:source         <https://identifiers.org/hgnc.symbol/VEGFR2> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000133703> .

<https://identifiers.org/ensembl/ENSG00000157764>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "BRAF" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000157764> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000157764" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000157764> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/673> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BRAF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P15056> , <https://identifiers.org/uniprot/H7C4S5> , <https://identifiers.org/uniprot/H7C560> , <https://identifiers.org/uniprot/A0A2R8Y679> , <https://identifiers.org/uniprot/A0A2R8Y467> , <https://identifiers.org/uniprot/A0A2R8Y8E0> , <https://identifiers.org/uniprot/H7C5K3> , <https://identifiers.org/uniprot/A0A2R8YDP5> , <https://identifiers.org/uniprot/A0A2R8Y492> , <https://identifiers.org/uniprot/A0A2U3TZI2> , <https://identifiers.org/uniprot/A0A2R8YES9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17853226> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/fe5d7> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A2R8Y467> , <http://purl.uniprot.org/uniprot/H7C4S5> , <http://purl.uniprot.org/uniprot/A0A2R8Y679> , <http://purl.uniprot.org/uniprot/H7C560> , <http://purl.uniprot.org/uniprot/A0A2R8YDP5> , <http://purl.uniprot.org/uniprot/P15056> , <http://purl.uniprot.org/uniprot/A0A2R8Y492> , <http://purl.uniprot.org/uniprot/H7C5K3> , <http://purl.uniprot.org/uniprot/A0A2U3TZI2> , <http://purl.uniprot.org/uniprot/A0A2R8YES9> , <http://purl.uniprot.org/uniprot/A0A2R8Y8E0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000157764> .

<https://identifiers.org/ensembl/ENSG00000105810>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CDK6" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105810> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105810" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105810> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1021> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDK6> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q00534> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911762> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f2882> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q00534> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105810> .

<https://identifiers.org/hmdb/HMDB0250539>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Crizotinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/KTEIFNKAUNYNJU-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0250539> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0250539" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idbf6d5582> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/20979469> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:77562> , <https://identifiers.org/chebi/CHEBI:77563> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/9772331> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0250539> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/KTEIFNKAUNYNJU-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11597571> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q82296813> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b11b2> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0250539> .

<https://identifiers.org/ensembl/ENSG00000143320>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CRABP2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000143320> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000143320" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000143320> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1382> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CRABP2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5SYZ4> , <https://identifiers.org/uniprot/P29373> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17909216> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c899d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5SYZ4> , <http://purl.uniprot.org/uniprot/P29373> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000143320> .

<https://identifiers.org/ensembl/ENSG00000266094>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RASSF5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000266094> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000266094" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id3782c246> , <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id1bbfd20d> ;
        dcterms:references  <https://identifiers.org/pubmed/15948711> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000266094> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/83593> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RASSF5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A075B763> , <https://identifiers.org/uniprot/Q8TEK8> , <https://identifiers.org/uniprot/Q8WWW0> , <https://identifiers.org/uniprot/A0A1B0GTG4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18047199> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/eedf3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A1B0GTG4> , <http://purl.uniprot.org/uniprot/A0A075B763> , <http://purl.uniprot.org/uniprot/Q8WWW0> , <http://purl.uniprot.org/uniprot/Q8TEK8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000266094> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id531ac1cd>
        rdf:type            wp:Interaction , wp:Inhibition , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/12024041> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id531ac1cd> ;
        wp:participants     <https://identifiers.org/ensembl/ENSG00000110092> , <https://identifiers.org/ensembl/ENSG00000068028> ;
        wp:source           <https://identifiers.org/ensembl/ENSG00000068028> ;
        wp:target           <https://identifiers.org/ensembl/ENSG00000110092> .

<https://identifiers.org/ensembl/ENSG00000051382>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PIK3CB" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000051382> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000051382" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000051382> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5291> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C565> , <https://identifiers.org/uniprot/H7C5C3> , <https://identifiers.org/uniprot/H0Y871> , <https://identifiers.org/uniprot/C9JYX0> , <https://identifiers.org/uniprot/H7C527> , <https://identifiers.org/uniprot/C9J345> , <https://identifiers.org/uniprot/P42338> , <https://identifiers.org/uniprot/F8WDJ8> , <https://identifiers.org/uniprot/Q68DL0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030549> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ddd41> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P42338> , <http://purl.uniprot.org/uniprot/Q68DL0> , <http://purl.uniprot.org/uniprot/H7C527> , <http://purl.uniprot.org/uniprot/H7C565> , <http://purl.uniprot.org/uniprot/H7C5C3> , <http://purl.uniprot.org/uniprot/C9J345> , <http://purl.uniprot.org/uniprot/H0Y871> , <http://purl.uniprot.org/uniprot/C9JYX0> , <http://purl.uniprot.org/uniprot/F8WDJ8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000051382> .

<https://identifiers.org/pubmed/19629074>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "19629074" ;
        dcterms:isPartOf    <https://identifiers.org/hgnc.symbol/VEGFR2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/19629074> .

<https://identifiers.org/ensembl/ENSG00000121879>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PIK3CA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000121879> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000121879" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000121879> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5290> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P42336> , <https://identifiers.org/uniprot/A0A2R8Y2F6> , <https://identifiers.org/uniprot/A0A6Q8PGV1> , <https://identifiers.org/uniprot/C9JAM9> , <https://identifiers.org/uniprot/C9J951> , <https://identifiers.org/uniprot/A0A6Q8PGN9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14887700> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a3d85> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9J951> , <http://purl.uniprot.org/uniprot/C9JAM9> , <http://purl.uniprot.org/uniprot/P42336> , <http://purl.uniprot.org/uniprot/A0A2R8Y2F6> , <http://purl.uniprot.org/uniprot/A0A6Q8PGV1> , <http://purl.uniprot.org/uniprot/A0A6Q8PGN9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000121879> .

<https://identifiers.org/wikidata/Q19903515>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Binimetinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ACWZRVQXLIRSDF-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/wikidata/Q19903515> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q19903515" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/38357801> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:145371> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/8463660> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304890> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ACWZRVQXLIRSDF-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID10288191> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q19903515> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cd6a5> ;
        foaf:page           <https://scholia.toolforge.org/Q19903515> .

<https://identifiers.org/ensembl/ENSG00000064012>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CASP8" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000064012> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000064012" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/f1a38> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a49fb> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000064012> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/841> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CASP8> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F8WF39> , <https://identifiers.org/uniprot/E7ETB7> , <https://identifiers.org/uniprot/A0A8Q3WKY8> , <https://identifiers.org/uniprot/A0A8Q3SI66> , <https://identifiers.org/uniprot/E7EQ06> , <https://identifiers.org/uniprot/Q14790> , <https://identifiers.org/uniprot/C9JB29> , <https://identifiers.org/uniprot/H7C0E2> , <https://identifiers.org/uniprot/A0A024R3Z8> , <https://identifiers.org/uniprot/E7EQ01> , <https://identifiers.org/uniprot/A0A8Q3SID9> , <https://identifiers.org/uniprot/E7EVN1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911965> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/caca3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E7ETB7> , <http://purl.uniprot.org/uniprot/E7EVN1> , <http://purl.uniprot.org/uniprot/C9JB29> , <http://purl.uniprot.org/uniprot/E7EQ06> , <http://purl.uniprot.org/uniprot/Q14790> , <http://purl.uniprot.org/uniprot/F8WF39> , <http://purl.uniprot.org/uniprot/A0A8Q3SI66> , <http://purl.uniprot.org/uniprot/H7C0E2> , <http://purl.uniprot.org/uniprot/E7EQ01> , <http://purl.uniprot.org/uniprot/A0A8Q3WKY8> , <http://purl.uniprot.org/uniprot/A0A024R3Z8> , <http://purl.uniprot.org/uniprot/A0A8Q3SID9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000064012> .

<https://identifiers.org/ensembl/ENSG00000118689>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FOXO3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000118689> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000118689" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118689> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2309> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FOXO3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A856PRE8> , <https://identifiers.org/uniprot/O43524> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17928794> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b83c7> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O43524> , <http://purl.uniprot.org/uniprot/A0A856PRE8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000118689> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a49fb>
        rdf:type            wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/17328863> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/a49fb> ;
        wp:participants     <https://identifiers.org/ensembl/ENSG00000064012> , <https://identifiers.org/ensembl/ENSG00000189283> ;
        wp:source           <https://identifiers.org/ensembl/ENSG00000189283> ;
        wp:target           <https://identifiers.org/ensembl/ENSG00000064012> .

<https://identifiers.org/ensembl/ENSG00000143924>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "EML4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000143924> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000143924" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000143924> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/27436> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EML4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9HC35> , <https://identifiers.org/uniprot/B5MBZ0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18038810> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a5d6d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9HC35> , <http://purl.uniprot.org/uniprot/B5MBZ0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000143924> .

<https://identifiers.org/ensembl/ENSG00000147889>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CDKN2A/ p16 INK4A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000147889> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000147889" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000147889> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1029> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDKN2A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q8N726> , <https://identifiers.org/uniprot/P42771> , <https://identifiers.org/uniprot/K7PML8> , <https://identifiers.org/uniprot/J3QRG6> , <https://identifiers.org/uniprot/K7ES20> , <https://identifiers.org/uniprot/K7ENC6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q5009957> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ce782> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/K7ENC6> , <http://purl.uniprot.org/uniprot/P42771> , <http://purl.uniprot.org/uniprot/J3QRG6> , <http://purl.uniprot.org/uniprot/K7PML8> , <http://purl.uniprot.org/uniprot/Q8N726> , <http://purl.uniprot.org/uniprot/K7ES20> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000147889> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4255&oldid=142399>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/wikipathways/WP707>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "p53 signaling" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP707> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP707" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/edb61> ;
        foaf:page           <https://www.wikipathways.org/instance/WP707> .

<https://identifiers.org/ensembl/ENSG00000068028>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RASSF1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000068028> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000068028" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idbdba7f13> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id3782c246> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id531ac1cd> ;
        dcterms:references  <https://identifiers.org/pubmed/17878233> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000068028> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/11186> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RASSF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9NS23> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18036269> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cfd51> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9NS23> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000068028> .

<https://identifiers.org/ensembl/ENSG00000007968>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "E2F2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000007968> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000007968" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000007968> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1870> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/E2F2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q14209> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/eb8d4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q14209> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000007968> .

<https://identifiers.org/ensembl/ENSG00000213281>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000213281> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000213281" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000213281> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4893> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5U091> , <https://identifiers.org/uniprot/P01111> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030215> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e8e0c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01111> , <http://purl.uniprot.org/uniprot/Q5U091> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000213281> .

<https://identifiers.org/ensembl/ENSG00000133703>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000133703> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000133703" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idbdba7f13> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idfe3b52ac> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idc5593e8> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000133703> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3845> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V4K2> , <https://identifiers.org/uniprot/G3V5T7> , <https://identifiers.org/uniprot/L7RSL8> , <https://identifiers.org/uniprot/A0A024RAV5> , <https://identifiers.org/uniprot/A0A8I5KUB5> , <https://identifiers.org/uniprot/A0A8I5KYH6> , <https://identifiers.org/uniprot/A0A8I5KQU3> , <https://identifiers.org/uniprot/A0A8I5KR86> , <https://identifiers.org/uniprot/A0A8I5KXN3> , <https://identifiers.org/uniprot/P01116> , <https://identifiers.org/uniprot/A0A8I5KQ21> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20969980> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e4f56> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c74da> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KUB5> , <http://purl.uniprot.org/uniprot/L7RSL8> , <http://purl.uniprot.org/uniprot/P01116> , <http://purl.uniprot.org/uniprot/A0A8I5KXN3> , <http://purl.uniprot.org/uniprot/G3V4K2> , <http://purl.uniprot.org/uniprot/A0A8I5KYH6> , <http://purl.uniprot.org/uniprot/A0A8I5KR86> , <http://purl.uniprot.org/uniprot/A0A024RAV5> , <http://purl.uniprot.org/uniprot/A0A8I5KQU3> , <http://purl.uniprot.org/uniprot/A0A8I5KQ21> , <http://purl.uniprot.org/uniprot/G3V5T7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000133703> .

<https://identifiers.org/ensembl/ENSG00000154229>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PRKCA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000154229> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000154229" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000154229> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5578> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKCA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/L7RSM7> , <https://identifiers.org/uniprot/J3KN97> , <https://identifiers.org/uniprot/P17252> , <https://identifiers.org/uniprot/J3KRN5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14912643> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e25a9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/L7RSM7> , <http://purl.uniprot.org/uniprot/P17252> , <http://purl.uniprot.org/uniprot/J3KN97> , <http://purl.uniprot.org/uniprot/J3KRN5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000154229> .

<https://identifiers.org/hgnc.symbol/RET>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RET" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/RET> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "RET" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSSSCG00000010199> , <https://identifiers.org/ensembl/ENSOANG00000046180> , <https://identifiers.org/ensembl/ENSG00000165731> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/100155053> , <https://identifiers.org/ncbigene/100076319> , <https://identifiers.org/ncbigene/5979> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RET> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A804HL71> , <https://identifiers.org/uniprot/A0A804HIK7> , <https://identifiers.org/uniprot/A0A024R7T2> , <https://identifiers.org/uniprot/A0A1W2PSA1> , <https://identifiers.org/uniprot/F1RG22> , <https://identifiers.org/uniprot/P07949> , <https://identifiers.org/uniprot/C9JYL6> , <https://identifiers.org/uniprot/A0A5F9ZHR6> , <https://identifiers.org/uniprot/A0A087WWB1> , <https://identifiers.org/uniprot/A0A5F9ZHB7> , <https://identifiers.org/uniprot/A0A5G2R607> , <https://identifiers.org/uniprot/A0A1W2PPN7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d7162> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P07949> , <http://purl.uniprot.org/uniprot/A0A5F9ZHB7> , <http://purl.uniprot.org/uniprot/A0A1W2PPN7> , <http://purl.uniprot.org/uniprot/A0A087WWB1> , <http://purl.uniprot.org/uniprot/C9JYL6> , <http://purl.uniprot.org/uniprot/A0A1W2PSA1> , <http://purl.uniprot.org/uniprot/A0A5G2R607> , <http://purl.uniprot.org/uniprot/A0A5F9ZHR6> , <http://purl.uniprot.org/uniprot/A0A024R7T2> , <http://purl.uniprot.org/uniprot/A0A804HIK7> , <http://purl.uniprot.org/uniprot/F1RG22> , <http://purl.uniprot.org/uniprot/A0A804HL71> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/RET> .

<https://identifiers.org/ensembl/ENSG00000077092>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RARB" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000077092> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000077092" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000077092> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5915> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RARB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KXD0> , <https://identifiers.org/uniprot/A0A8I5KNZ0> , <https://identifiers.org/uniprot/P10826> , <https://identifiers.org/uniprot/F1D8S6> , <https://identifiers.org/uniprot/D6RBI3> , <https://identifiers.org/uniprot/A0A8I5KVP8> , <https://identifiers.org/uniprot/A0A8I5KVJ9> , <https://identifiers.org/uniprot/A0A8I5KWP3> , <https://identifiers.org/uniprot/A0A8I5KUH8> , <https://identifiers.org/uniprot/Q5QHG3> , <https://identifiers.org/uniprot/A0A8I5KSR9> , <https://identifiers.org/uniprot/A0A8I5KQX3> , <https://identifiers.org/uniprot/A0A8I5KVN9> , <https://identifiers.org/uniprot/A0A8I5KXT3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031041> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ec14d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KVJ9> , <http://purl.uniprot.org/uniprot/A0A8I5KVN9> , <http://purl.uniprot.org/uniprot/D6RBI3> , <http://purl.uniprot.org/uniprot/A0A8I5KXT3> , <http://purl.uniprot.org/uniprot/A0A8I5KSR9> , <http://purl.uniprot.org/uniprot/Q5QHG3> , <http://purl.uniprot.org/uniprot/A0A8I5KQX3> , <http://purl.uniprot.org/uniprot/P10826> , <http://purl.uniprot.org/uniprot/F1D8S6> , <http://purl.uniprot.org/uniprot/A0A8I5KWP3> , <http://purl.uniprot.org/uniprot/A0A8I5KVP8> , <http://purl.uniprot.org/uniprot/A0A8I5KNZ0> , <http://purl.uniprot.org/uniprot/A0A8I5KXD0> , <http://purl.uniprot.org/uniprot/A0A8I5KUH8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000077092> .

<https://identifiers.org/wikidata/Q7833138>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Trametinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/LIRYPHYGHXZJBZ-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/wikidata/Q7833138> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q7833138" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/29438093> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:75998> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/9881833> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/LIRYPHYGHXZJBZ-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11707110> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q7833138> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d7c86> ;
        foaf:page           <https://scholia.toolforge.org/Q7833138> .

<https://identifiers.org/wikipathways/WP4172>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "PI3K-Akt signaling" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP4172> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP4172" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e820c> ;
        foaf:page           <https://www.wikipathways.org/instance/WP4172> .

<https://identifiers.org/ensembl/ENSG00000189283>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FHIT" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000189283> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000189283" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a49fb> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/17328863> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000189283> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2272> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FHIT> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P49789> , <https://identifiers.org/uniprot/E9PBZ0> , <https://identifiers.org/uniprot/A0A024R366> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17928393> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e8b06> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P49789> , <http://purl.uniprot.org/uniprot/A0A024R366> , <http://purl.uniprot.org/uniprot/E9PBZ0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000189283> .

<https://identifiers.org/wikipathways/WP4255_r142399>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP4255> ;
        dc:source               "WikiPathways" ;
        dc:title                "Non-small cell lung cancer"@en ;
        dcterms:description     "Non-small cell lung cancer (NSCLC) represents 85% of lung cancer and is defined as any type of epithelial lung cancer that is _not_ small cell carcinoma, including squamous cell (SCC), adeno (AC) and large-cell carcinoma. \nMutations in NSCLC:\nKRAS (mutated in ~29% of NSCLC patients) inactivates its GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. \nMutations or overexpression of EGFR (~22% of NSCLC patients) leads to increased proliferation. \nThe abnormal fusion of EML4-ALK (~5% of NSCLC patients) leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. \nInactivating mutation of p53 (~50% of NSCLC patients) leads to reduced apoptosis and proliferation. \nThe protein encoded by the p16INK4a, CDKN2A, inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. p16INK4a is mutated in ~12% of NSCLC patients, which leads to a loss of this inhibitory effect.\n\nRARB is a nuclear retinoic acid receptor whose function is often lost in NSCLC, leading to a loss of cell growth control. \n\nThis pathway was developed based on [KEGG](https://www.kegg.jp/dbget-bin/www_bget?pathway+map05223). Phosphorylation sites were added based on information from [PhosphoSitePlus (R)](https://www.phosphosite.org)." ;
        dcterms:identifier      "WP4255" ;
        dcterms:references      <https://identifiers.org/pubmed/28572459> , <https://identifiers.org/pubmed/25514926> ;
        cito:cites              <https://identifiers.org/pubmed/15948711> , <https://identifiers.org/pubmed/39983053> , <https://identifiers.org/pubmed/17328863> , <https://identifiers.org/pubmed/29128428> , <https://identifiers.org/pubmed/19629074> , <https://identifiers.org/pubmed/23322901> , <https://identifiers.org/pubmed/12024041> , <https://identifiers.org/pubmed/38357801> , <https://identifiers.org/pubmed/20979469> , <https://identifiers.org/pubmed/17878233> , <https://identifiers.org/pubmed/25514926> , <https://identifiers.org/pubmed/28675058> , <https://identifiers.org/pubmed/34118197> , <https://identifiers.org/pubmed/29438093> , <https://identifiers.org/pubmed/28572459> , <https://identifiers.org/pubmed/38375734> ;
        wp:cellTypeOntologyTag  obo:CL_0002328 ;
        wp:diseaseOntologyTag   obo:DOID_3910 , obo:DOID_1324 , obo:DOID_1749 , obo:DOID_3908 , obo:DOID_4556 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP4255_r142399> ;
        wp:ontologyTag          obo:PW_0000703 , obo:DOID_4556 , obo:PW_0000605 , obo:DOID_1749 , obo:CL_0002328 , obo:PW_0000013 , obo:DOID_3908 , obo:DOID_3910 , wp:Curation:CPTAC , wp:Curation:AnalysisCollection , wp:Curation:Diseases , obo:DOID_1324 ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000013 , obo:PW_0000605 , obo:PW_0000703 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4255&oldid=142399> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4255&oldid=142399> ;
        foaf:page               <http://www.wikipathways.org/instance/WP4255_r142399> .

<https://identifiers.org/ensembl/ENSG00000139687>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RB1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000139687> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000139687" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idb6bdd1ca> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000139687> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5925> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A024RDV3> , <https://identifiers.org/uniprot/A0A3B3IS71> , <https://identifiers.org/uniprot/Q92728> , <https://identifiers.org/uniprot/P06400> , <https://identifiers.org/uniprot/A0A2R8YFL6> , <https://identifiers.org/uniprot/A0A2R8Y743> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q40108> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cc883> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P06400> , <http://purl.uniprot.org/uniprot/A0A2R8Y743> , <http://purl.uniprot.org/uniprot/A0A3B3IS71> , <http://purl.uniprot.org/uniprot/A0A2R8YFL6> , <http://purl.uniprot.org/uniprot/A0A024RDV3> , <http://purl.uniprot.org/uniprot/Q92728> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000139687> .

<https://identifiers.org/hmdb/HMDB0254164>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Lorlatinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/IIXWYSCJSQVBQM-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0254164> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0254164" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/38375734> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/35143249> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0254164> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/IIXWYSCJSQVBQM-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID78162481> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b1207> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0254164> .

<https://identifiers.org/ensembl/ENSG00000101412>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "E2F1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000101412> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000101412" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000101412> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1869> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/E2F1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q01094> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15333016> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f11f2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q01094> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000101412> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id3fb0862b>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id3fb0862b> ;
        wp:participants   <https://identifiers.org/hgnc.symbol/MET> , <https://identifiers.org/hgnc.symbol/HGF> ;
        wp:source         <https://identifiers.org/hgnc.symbol/HGF> ;
        wp:target         <https://identifiers.org/hgnc.symbol/MET> .

<https://identifiers.org/ensembl/ENSG00000166501>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PRKCB" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000166501> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000166501" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000166501> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5579> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKCB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/I3L148> , <https://identifiers.org/uniprot/H3BV73> , <https://identifiers.org/uniprot/I3L1Z0> , <https://identifiers.org/uniprot/P05771> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030771> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d9602> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/I3L148> , <http://purl.uniprot.org/uniprot/I3L1Z0> , <http://purl.uniprot.org/uniprot/P05771> , <http://purl.uniprot.org/uniprot/H3BV73> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000166501> .

<https://identifiers.org/wikipathways/WP4223>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "Ras signaling" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP4223> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP4223" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e38e7> ;
        foaf:page           <https://www.wikipathways.org/instance/WP4223> .

<https://identifiers.org/chebi/CHEBI:16595>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "IP3" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MMWCIQZXVOZEGG-XJTPDSDZSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:16595> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:16595" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16595> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388562> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001498> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MMWCIQZXVOZEGG-XJTPDSDZSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01245> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439456> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q26998374> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dd770> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16595> .

<https://identifiers.org/pubmed/29128428>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "29128428" ;
        dcterms:isPartOf    <https://identifiers.org/hgnc.symbol/KIF5A> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/29128428> .

<https://identifiers.org/ensembl/ENSG00000146648>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "EGFR" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000146648> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000146648" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000146648> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1956> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EGFR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JYS6> , <https://identifiers.org/uniprot/P00533> , <https://identifiers.org/uniprot/A0A8V8TPW8> , <https://identifiers.org/uniprot/Q504U8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14865565> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d1936> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P00533> , <http://purl.uniprot.org/uniprot/A0A8V8TPW8> , <http://purl.uniprot.org/uniprot/C9JYS6> , <http://purl.uniprot.org/uniprot/Q504U8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000146648> .

<https://identifiers.org/pubmed/28572459>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "28572459" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/28572459> .

<https://identifiers.org/ensembl/ENSG00000173757>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "STAT5B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000173757> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000173757" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000173757> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6777> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STAT5B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9J4I3> , <https://identifiers.org/uniprot/A0A8V8TP00> , <https://identifiers.org/uniprot/A0A8V8TM84> , <https://identifiers.org/uniprot/A0A8V8TP21> , <https://identifiers.org/uniprot/A0A8V8TMR0> , <https://identifiers.org/uniprot/A0A8V8TMP4> , <https://identifiers.org/uniprot/P51692> , <https://identifiers.org/uniprot/A0A8V8TM91> , <https://identifiers.org/uniprot/A0A8V8TP16> , <https://identifiers.org/uniprot/A0A8V8TMQ6> , <https://identifiers.org/uniprot/A0A8V8TMA6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031752> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f7f2a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TMP4> , <http://purl.uniprot.org/uniprot/A0A8V8TM91> , <http://purl.uniprot.org/uniprot/A0A8V8TM84> , <http://purl.uniprot.org/uniprot/A0A8V8TMR0> , <http://purl.uniprot.org/uniprot/C9J4I3> , <http://purl.uniprot.org/uniprot/A0A8V8TMA6> , <http://purl.uniprot.org/uniprot/P51692> , <http://purl.uniprot.org/uniprot/A0A8V8TP16> , <http://purl.uniprot.org/uniprot/A0A8V8TMQ6> , <http://purl.uniprot.org/uniprot/A0A8V8TP21> , <http://purl.uniprot.org/uniprot/A0A8V8TP00> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000173757> .

<https://identifiers.org/ensembl/ENSG00000099860>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GADD45B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000099860> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000099860" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000099860> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4616> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GADD45B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q6IX74> , <https://identifiers.org/uniprot/K7EM97> , <https://identifiers.org/uniprot/O75293> , <https://identifiers.org/uniprot/K7EPQ8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18029722> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e51ed> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O75293> , <http://purl.uniprot.org/uniprot/Q6IX74> , <http://purl.uniprot.org/uniprot/K7EM97> , <http://purl.uniprot.org/uniprot/K7EPQ8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000099860> .

<https://identifiers.org/hmdb/HMDB0304855>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Pralsetinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/GBLBJPZSROAGMF-BATDWUPUSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0304855> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0304855" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/39983053> , <https://identifiers.org/pubmed/34118197> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/71060332> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304855> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/GBLBJPZSROAGMF-BATDWUPUSA-N> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/fcd5e> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0304855> .

<https://identifiers.org/pubmed/29438093>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "29438093" ;
        dcterms:isPartOf    <https://identifiers.org/chebi/CHEBI:75045> , <https://identifiers.org/wikidata/Q7833138> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/29438093> .

<https://identifiers.org/chebi/CHEBI:16618>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "PIP3" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/RQQIRMLGKSPXSE-UQPICLANSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:16618> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:16618" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id15d33a28> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16618> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/34980938> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0004249> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/RQQIRMLGKSPXSE-UQPICLANSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C05981> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMGP09010000> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q28797898> , <http://www.wikidata.org/entity/Q130305209> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c2ceb> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMGP09010000> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16618> .

<https://identifiers.org/pubmed/39983053>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "39983053" ;
        dcterms:isPartOf    <https://identifiers.org/hmdb/HMDB0304855> , <https://identifiers.org/hmdb/HMDB0304865> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/39983053> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4255&oldid=142399>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/e4130>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/e4130> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000164305> , <https://identifiers.org/ensembl/ENSG00000132906> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000132906> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000164305> .

<https://identifiers.org/pubmed/12024041>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "12024041" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id531ac1cd> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/12024041> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idbdba7f13>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/idbdba7f13> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000068028> , <https://identifiers.org/ensembl/ENSG00000133703> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000133703> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000068028> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/f1a38>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/f1a38> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000015475> , <https://identifiers.org/ensembl/ENSG00000064012> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000064012> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000015475> .

<https://identifiers.org/hgnc.symbol/MET>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MET" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/MET> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "MET" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idbf6d5582> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/e1eea> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id3fb0862b> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105976> , <https://identifiers.org/ensembl/ENSSSCG00000024351> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/654328> , <https://identifiers.org/ncbigene/4233> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MET> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C130> , <https://identifiers.org/uniprot/F1SJC6> , <https://identifiers.org/uniprot/K7GPY4> , <https://identifiers.org/uniprot/H7C174> , <https://identifiers.org/uniprot/A0A024R728> , <https://identifiers.org/uniprot/A0A024R759> , <https://identifiers.org/uniprot/C9JKM5> , <https://identifiers.org/uniprot/Q2QLE0> , <https://identifiers.org/uniprot/E6Y365> , <https://identifiers.org/uniprot/P08581> , <https://identifiers.org/uniprot/A0A4X1W4M3> , <https://identifiers.org/uniprot/A0A4X1W479> , <https://identifiers.org/uniprot/A0A5G2QT81> , <https://identifiers.org/uniprot/A0A4X1W3C9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/bb94a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A4X1W3C9> , <http://purl.uniprot.org/uniprot/H7C174> , <http://purl.uniprot.org/uniprot/A0A5G2QT81> , <http://purl.uniprot.org/uniprot/A0A4X1W479> , <http://purl.uniprot.org/uniprot/K7GPY4> , <http://purl.uniprot.org/uniprot/E6Y365> , <http://purl.uniprot.org/uniprot/H7C130> , <http://purl.uniprot.org/uniprot/Q2QLE0> , <http://purl.uniprot.org/uniprot/A0A024R759> , <http://purl.uniprot.org/uniprot/A0A024R728> , <http://purl.uniprot.org/uniprot/F1SJC6> , <http://purl.uniprot.org/uniprot/A0A4X1W4M3> , <http://purl.uniprot.org/uniprot/C9JKM5> , <http://purl.uniprot.org/uniprot/P08581> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/MET> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idb6bdd1ca>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/idb6bdd1ca> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000139687> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/ensembl/ENSG00000186350>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RXRA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000186350> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000186350" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000186350> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6256> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RXRA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F1D8Q5> , <https://identifiers.org/uniprot/A0A3B3IS44> , <https://identifiers.org/uniprot/P19793> , <https://identifiers.org/uniprot/A0A5F9ZHH6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17516011> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a46d2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P19793> , <http://purl.uniprot.org/uniprot/A0A3B3IS44> , <http://purl.uniprot.org/uniprot/A0A5F9ZHH6> , <http://purl.uniprot.org/uniprot/F1D8Q5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000186350> .

<https://identifiers.org/pubmed/38357801>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "38357801" ;
        dcterms:isPartOf    <https://identifiers.org/hmdb/HMDB0304887> , <https://identifiers.org/wikidata/Q19903515> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/38357801> .

<https://identifiers.org/ensembl/ENSG00000002330>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "BAD" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000002330> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000002330" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000002330> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/572> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BAD> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q92934> , <https://identifiers.org/uniprot/F5H3B1> , <https://identifiers.org/uniprot/A8MXU7> , <https://identifiers.org/uniprot/F5H1R6> , <https://identifiers.org/uniprot/F5GYS3> , <https://identifiers.org/uniprot/A0A024R562> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14907705> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/caa11> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q92934> , <http://purl.uniprot.org/uniprot/F5H1R6> , <http://purl.uniprot.org/uniprot/F5GYS3> , <http://purl.uniprot.org/uniprot/A8MXU7> , <http://purl.uniprot.org/uniprot/F5H3B1> , <http://purl.uniprot.org/uniprot/A0A024R562> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000002330> .

<https://identifiers.org/ensembl/ENSG00000126934>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MAP2K2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000126934> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000126934" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000126934> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5605> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAP2K2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/M0R1B6> , <https://identifiers.org/uniprot/P36507> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030794> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dd9ad> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/M0R1B6> , <http://purl.uniprot.org/uniprot/P36507> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000126934> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id15d33a28>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id15d33a28> ;
        wp:participants   <https://identifiers.org/hgnc.symbol/PDPK1> , <https://identifiers.org/chebi/CHEBI:16618> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:16618> ;
        wp:target         <https://identifiers.org/hgnc.symbol/PDPK1> .

<https://identifiers.org/ensembl/ENSG00000087088>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "BAX" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000087088> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000087088" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000087088> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/581> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BAX> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YA56> , <https://identifiers.org/uniprot/I6LPK7> , <https://identifiers.org/uniprot/Q07812> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905392> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c39a7> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H0YA56> , <http://purl.uniprot.org/uniprot/Q07812> , <http://purl.uniprot.org/uniprot/I6LPK7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000087088> .

<https://identifiers.org/ensembl/ENSG00000015475>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "BID" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000015475> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000015475" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a9afe> , <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/f1a38> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000015475> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/637> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BID> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B2ZP79> , <https://identifiers.org/uniprot/P55957> , <https://identifiers.org/uniprot/A8ASI8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18247971> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f105a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/B2ZP79> , <http://purl.uniprot.org/uniprot/P55957> , <http://purl.uniprot.org/uniprot/A8ASI8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000015475> .

<https://identifiers.org/hgnc.symbol/KIF5C>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "KIF5C" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/KIF5C> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "KIF5C" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSOANG00000011829> , <https://identifiers.org/ensembl/ENSSSCG00000022919> , <https://identifiers.org/ensembl/ENSG00000168280> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3800> , <https://identifiers.org/ncbigene/100622102> , <https://identifiers.org/ncbigene/100088788> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KIF5C> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V581> , <https://identifiers.org/uniprot/A0A7I2V352> , <https://identifiers.org/uniprot/I3LUB8> , <https://identifiers.org/uniprot/A0A7I2V4K6> , <https://identifiers.org/uniprot/A0A480PZV2> , <https://identifiers.org/uniprot/A0A7I2V3V4> , <https://identifiers.org/uniprot/A0A4X1THT2> , <https://identifiers.org/uniprot/O60282> , <https://identifiers.org/uniprot/F7ART1> , <https://identifiers.org/uniprot/A0A7I2YQQ7> , <https://identifiers.org/uniprot/A0A7I2YQB4> , <https://identifiers.org/uniprot/A0A7I2V492> , <https://identifiers.org/uniprot/A0A7I2V3N5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cc6ad> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2V581> , <http://purl.uniprot.org/uniprot/A0A4X1THT2> , <http://purl.uniprot.org/uniprot/A0A7I2V492> , <http://purl.uniprot.org/uniprot/A0A7I2V4K6> , <http://purl.uniprot.org/uniprot/O60282> , <http://purl.uniprot.org/uniprot/A0A7I2V3V4> , <http://purl.uniprot.org/uniprot/A0A480PZV2> , <http://purl.uniprot.org/uniprot/F7ART1> , <http://purl.uniprot.org/uniprot/A0A7I2YQB4> , <http://purl.uniprot.org/uniprot/A0A7I2V352> , <http://purl.uniprot.org/uniprot/A0A7I2YQQ7> , <http://purl.uniprot.org/uniprot/I3LUB8> , <http://purl.uniprot.org/uniprot/A0A7I2V3N5> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/KIF5C> .

<https://identifiers.org/ensembl/ENSG00000124762>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CDKN1A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000124762> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000124762" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000124762> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1026> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDKN1A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P38936> , <https://identifiers.org/uniprot/A0A024RCX5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14902453> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c9c87> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P38936> , <http://purl.uniprot.org/uniprot/A0A024RCX5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000124762> .

<https://identifiers.org/pubmed/17878233>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "17878233" ;
        dcterms:isPartOf    <https://identifiers.org/ensembl/ENSG00000068028> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17878233> .

<https://identifiers.org/pubmed/17328863>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "17328863" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a49fb> , <https://identifiers.org/ensembl/ENSG00000189283> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17328863> .

<https://identifiers.org/ensembl/ENSG00000204231>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RXRB" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000204231> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000204231" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000204231> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6257> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RXRB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PK75> , <https://identifiers.org/uniprot/Q5STP9> , <https://identifiers.org/uniprot/P28702> , <https://identifiers.org/uniprot/A0A0S2Z570> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f4669> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28702> , <http://purl.uniprot.org/uniprot/A0A0S2Z570> , <http://purl.uniprot.org/uniprot/Q5STP9> , <http://purl.uniprot.org/uniprot/E9PK75> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000204231> .

<https://identifiers.org/ensembl/ENSG00000171094>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ALK" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000171094> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000171094" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171094> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/238> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ALK> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A087WZL3> , <https://identifiers.org/uniprot/E7EPW7> , <https://identifiers.org/uniprot/H7BZ33> , <https://identifiers.org/uniprot/Q9UM73> , <https://identifiers.org/uniprot/A0A0K2YUJ3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17824987> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cbd14> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087WZL3> , <http://purl.uniprot.org/uniprot/H7BZ33> , <http://purl.uniprot.org/uniprot/E7EPW7> , <http://purl.uniprot.org/uniprot/A0A0K2YUJ3> , <http://purl.uniprot.org/uniprot/Q9UM73> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000171094> .

<https://identifiers.org/ensembl/ENSG00000126583>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PRKCG" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000126583> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000126583" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000126583> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5582> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKCG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A804HHY0> , <https://identifiers.org/uniprot/M0R0I9> , <https://identifiers.org/uniprot/H7BZ60> , <https://identifiers.org/uniprot/P05129> , <https://identifiers.org/uniprot/M0R0Z4> , <https://identifiers.org/uniprot/A0A804HIU5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030774> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/bdf74> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/M0R0Z4> , <http://purl.uniprot.org/uniprot/A0A804HHY0> , <http://purl.uniprot.org/uniprot/A0A804HIU5> , <http://purl.uniprot.org/uniprot/M0R0I9> , <http://purl.uniprot.org/uniprot/P05129> , <http://purl.uniprot.org/uniprot/H7BZ60> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000126583> .

<https://identifiers.org/pubmed/28675058>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "28675058" ;
        dcterms:isPartOf    <https://identifiers.org/chebi/CHEBI:90227> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/28675058> .

<https://identifiers.org/pmc/PMC12174437>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC12174437" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4255> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC12174437> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idbf6d5582>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/idbf6d5582> ;
        wp:participants   <https://identifiers.org/hgnc.symbol/MET> , <https://identifiers.org/hmdb/HMDB0250539> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0250539> ;
        wp:target         <https://identifiers.org/hgnc.symbol/MET> .

<https://identifiers.org/ensembl/ENSG00000166426>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CRABP1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000166426> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000166426" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000166426> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1381> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CRABP1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P29762> , <https://identifiers.org/uniprot/F1T0F7> , <https://identifiers.org/uniprot/B5MCB5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17909215> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a3f77> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/B5MCB5> , <http://purl.uniprot.org/uniprot/F1T0F7> , <http://purl.uniprot.org/uniprot/P29762> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000166426> .

<https://identifiers.org/wikipathways/WP4255>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4255_r142399> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/e1eea>
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        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/e1eea> ;
        wp:participants   <https://identifiers.org/hgnc.symbol/GRB2> , <https://identifiers.org/hgnc.symbol/MET> ;
        wp:source         <https://identifiers.org/hgnc.symbol/MET> ;
        wp:target         <https://identifiers.org/hgnc.symbol/GRB2> .

<https://identifiers.org/pmc/PMC9614744>
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        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC9614744" ;
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        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9614744> .

<https://identifiers.org/ensembl/ENSG00000169032>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000169032> ;
        dc:source           "Ensembl" ;
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        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000169032> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5604> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAP2K1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5QJC1> , <https://identifiers.org/uniprot/A4QPA9> , <https://identifiers.org/uniprot/A0A8I5QJL9> , <https://identifiers.org/uniprot/A0A8I5KXN4> , <https://identifiers.org/uniprot/B4DFY5> , <https://identifiers.org/uniprot/A0A8I5QJP8> , <https://identifiers.org/uniprot/Q02750> , <https://identifiers.org/uniprot/H3BRW9> , <https://identifiers.org/uniprot/A0A8I5QJ96> , <https://identifiers.org/uniprot/A0A8I5KYB4> , <https://identifiers.org/uniprot/A0A8I5KRX5> , <https://identifiers.org/uniprot/A0A8I5KYS7> , <https://identifiers.org/uniprot/A0A8I5KVF6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030793> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ff402> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KXN4> , <http://purl.uniprot.org/uniprot/A0A8I5KVF6> , <http://purl.uniprot.org/uniprot/A0A8I5KRX5> , <http://purl.uniprot.org/uniprot/A0A8I5QJ96> , <http://purl.uniprot.org/uniprot/A0A8I5QJL9> , <http://purl.uniprot.org/uniprot/A0A8I5KYS7> , <http://purl.uniprot.org/uniprot/A0A8I5QJC1> , <http://purl.uniprot.org/uniprot/H3BRW9> , <http://purl.uniprot.org/uniprot/B4DFY5> , <http://purl.uniprot.org/uniprot/A0A8I5QJP8> , <http://purl.uniprot.org/uniprot/A4QPA9> , <http://purl.uniprot.org/uniprot/A0A8I5KYB4> , <http://purl.uniprot.org/uniprot/Q02750> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000169032> .

<https://identifiers.org/ensembl/ENSG00000101109>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "STK4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000101109> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000101109" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id1bbfd20d> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/15948711> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000101109> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6789> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STK4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5H5B4> , <https://identifiers.org/uniprot/A0A087WVN8> , <https://identifiers.org/uniprot/Q13043> , <https://identifiers.org/uniprot/A0A8V8TLK1> , <https://identifiers.org/uniprot/A0A8V8TLH7> , <https://identifiers.org/uniprot/A0A8V8TM13> , <https://identifiers.org/uniprot/A0A8V8TNA0> , <https://identifiers.org/uniprot/A0A8V8TN08> , <https://identifiers.org/uniprot/A0A087WYT4> , <https://identifiers.org/uniprot/A0A8V8TM18> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031761> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e2fe6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TM18> , <http://purl.uniprot.org/uniprot/F5H5B4> , <http://purl.uniprot.org/uniprot/A0A8V8TLH7> , <http://purl.uniprot.org/uniprot/A0A087WYT4> , <http://purl.uniprot.org/uniprot/Q13043> , <http://purl.uniprot.org/uniprot/A0A087WVN8> , <http://purl.uniprot.org/uniprot/A0A8V8TLK1> , <http://purl.uniprot.org/uniprot/A0A8V8TN08> , <http://purl.uniprot.org/uniprot/A0A8V8TNA0> , <http://purl.uniprot.org/uniprot/A0A8V8TM13> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000101109> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a9afe>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/a9afe> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000172115> , <https://identifiers.org/ensembl/ENSG00000015475> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000015475> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000172115> .

<https://identifiers.org/ensembl/ENSG00000122008>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "POLK" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000122008> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000122008" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000122008> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/51426> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/POLK> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D6RDX9> , <https://identifiers.org/uniprot/D6R9M8> , <https://identifiers.org/uniprot/D6RAE5> , <https://identifiers.org/uniprot/Q9UBT6> , <https://identifiers.org/uniprot/A0A024RAP4> , <https://identifiers.org/uniprot/D6RAI7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18040278> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c7e30> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D6RAE5> , <http://purl.uniprot.org/uniprot/D6RAI7> , <http://purl.uniprot.org/uniprot/A0A024RAP4> , <http://purl.uniprot.org/uniprot/Q9UBT6> , <http://purl.uniprot.org/uniprot/D6RDX9> , <http://purl.uniprot.org/uniprot/D6R9M8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000122008> .

<https://identifiers.org/hmdb/HMDB0249380>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Brigatinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/AILRADAXUVEEIR-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0249380> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0249380" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/38375734> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:232810> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/34982928> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0249380> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/AILRADAXUVEEIR-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID68165256> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27456393> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c3e97> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0249380> .

<https://identifiers.org/ensembl/ENSG00000105221>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105221> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105221" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105221> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/208> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3KT31> , <https://identifiers.org/uniprot/M0QZW8> , <https://identifiers.org/uniprot/M0R0P9> , <https://identifiers.org/uniprot/J3KSY8> , <https://identifiers.org/uniprot/J3KRI8> , <https://identifiers.org/uniprot/M0R283> , <https://identifiers.org/uniprot/E7EVP8> , <https://identifiers.org/uniprot/M0R275> , <https://identifiers.org/uniprot/J3QLS6> , <https://identifiers.org/uniprot/C9JC83> , <https://identifiers.org/uniprot/J3KTP4> , <https://identifiers.org/uniprot/A0A1B0GXA2> , <https://identifiers.org/uniprot/A0A5F9ZHJ8> , <https://identifiers.org/uniprot/J3QL45> , <https://identifiers.org/uniprot/M0QZK3> , <https://identifiers.org/uniprot/J3KTC6> , <https://identifiers.org/uniprot/A0A0A0MRF1> , <https://identifiers.org/uniprot/J3QKW1> , <https://identifiers.org/uniprot/C9J258> , <https://identifiers.org/uniprot/P31751> , <https://identifiers.org/uniprot/A8MX96> , <https://identifiers.org/uniprot/C9JHS6> , <https://identifiers.org/uniprot/C9JIF6> , <https://identifiers.org/uniprot/C9JIJ1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q4652205> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d3a0e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/M0QZW8> , <http://purl.uniprot.org/uniprot/M0R0P9> , <http://purl.uniprot.org/uniprot/J3QL45> , <http://purl.uniprot.org/uniprot/J3QLS6> , <http://purl.uniprot.org/uniprot/C9JIJ1> , <http://purl.uniprot.org/uniprot/A0A5F9ZHJ8> , <http://purl.uniprot.org/uniprot/J3KRI8> , <http://purl.uniprot.org/uniprot/C9JC83> , <http://purl.uniprot.org/uniprot/M0R283> , <http://purl.uniprot.org/uniprot/A0A1B0GXA2> , <http://purl.uniprot.org/uniprot/P31751> , <http://purl.uniprot.org/uniprot/C9JIF6> , <http://purl.uniprot.org/uniprot/M0R275> , <http://purl.uniprot.org/uniprot/J3KT31> , <http://purl.uniprot.org/uniprot/M0QZK3> , <http://purl.uniprot.org/uniprot/C9JHS6> , <http://purl.uniprot.org/uniprot/J3KSY8> , <http://purl.uniprot.org/uniprot/J3KTC6> , <http://purl.uniprot.org/uniprot/C9J258> , <http://purl.uniprot.org/uniprot/J3QKW1> , <http://purl.uniprot.org/uniprot/A8MX96> , <http://purl.uniprot.org/uniprot/A0A0A0MRF1> , <http://purl.uniprot.org/uniprot/E7EVP8> , <http://purl.uniprot.org/uniprot/J3KTP4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105221> .

<https://identifiers.org/ensembl/ENSG00000105639>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "JAK3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105639> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105639" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105639> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3718> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/JAK3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P52333> , <https://identifiers.org/uniprot/A0A024R7M7> , <https://identifiers.org/uniprot/A0A0S2Z4R7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14914496> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d1a63> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0S2Z4R7> , <http://purl.uniprot.org/uniprot/A0A024R7M7> , <http://purl.uniprot.org/uniprot/P52333> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105639> .

<https://identifiers.org/ensembl/ENSG00000030110>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "BAK1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000030110> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000030110" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000030110> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/578> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BAK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0S2Z391> , <https://identifiers.org/uniprot/Q16611> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14907689> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/aa2c5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q16611> , <http://purl.uniprot.org/uniprot/A0A0S2Z391> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000030110> .

<https://identifiers.org/ensembl/ENSG00000141736>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ERBB2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000141736> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000141736" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000141736> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2064> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ERBB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3QRX1> , <https://identifiers.org/uniprot/J3QLU9> , <https://identifiers.org/uniprot/J3QRJ7> , <https://identifiers.org/uniprot/J3KTI5> , <https://identifiers.org/uniprot/J3QLV2> , <https://identifiers.org/uniprot/X5DNK3> , <https://identifiers.org/uniprot/F5H1T4> , <https://identifiers.org/uniprot/B4DTR1> , <https://identifiers.org/uniprot/J3QL83> , <https://identifiers.org/uniprot/P04626> , <https://identifiers.org/uniprot/J3KRI9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14877486> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c95e2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3QL83> , <http://purl.uniprot.org/uniprot/J3KTI5> , <http://purl.uniprot.org/uniprot/X5DNK3> , <http://purl.uniprot.org/uniprot/J3QRX1> , <http://purl.uniprot.org/uniprot/J3QLU9> , <http://purl.uniprot.org/uniprot/F5H1T4> , <http://purl.uniprot.org/uniprot/J3KRI9> , <http://purl.uniprot.org/uniprot/P04626> , <http://purl.uniprot.org/uniprot/B4DTR1> , <http://purl.uniprot.org/uniprot/J3QRJ7> , <http://purl.uniprot.org/uniprot/J3QLV2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000141736> .

<https://identifiers.org/pubmed/20979469>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "20979469" ;
        dcterms:isPartOf    <https://identifiers.org/hmdb/HMDB0250539> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/20979469> .

<https://identifiers.org/hmdb/HMDB0304887>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Encorafenib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/CMJCXYNUCSMDBY-ZDUSSCGKSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0304887> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0304887" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/38357801> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/28536139> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304887> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/CMJCXYNUCSMDBY-ZDUSSCGKSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID50922675> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15409405> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ca9aa> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0304887> .

<https://identifiers.org/ensembl/ENSG00000174775>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "HRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000174775> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000174775" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000174775> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3265> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01112> , <https://identifiers.org/uniprot/A0A804HJ06> , <https://identifiers.org/uniprot/X5D945> , <https://identifiers.org/uniprot/A0A804HKM6> , <https://identifiers.org/uniprot/A0A8C8MQR2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c4f4d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/X5D945> , <http://purl.uniprot.org/uniprot/P01112> , <http://purl.uniprot.org/uniprot/A0A804HJ06> , <http://purl.uniprot.org/uniprot/A0A804HKM6> , <http://purl.uniprot.org/uniprot/A0A8C8MQR2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000174775> .

<https://identifiers.org/ensembl/ENSG00000171608>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3CD" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000171608> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000171608" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171608> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5293> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CD> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B7ZM44> , <https://identifiers.org/uniprot/A0A8V8TNP1> , <https://identifiers.org/uniprot/O00329> , <https://identifiers.org/uniprot/A0A8V8TMM0> , <https://identifiers.org/uniprot/A0A8V8TM62> , <https://identifiers.org/uniprot/A0A8V8TNW9> , <https://identifiers.org/uniprot/A0A2K8FKV1> , <https://identifiers.org/uniprot/F8W9P4> , <https://identifiers.org/uniprot/A0A8V8TML5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14887732> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b26ae> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TNW9> , <http://purl.uniprot.org/uniprot/A0A8V8TMM0> , <http://purl.uniprot.org/uniprot/B7ZM44> , <http://purl.uniprot.org/uniprot/O00329> , <http://purl.uniprot.org/uniprot/A0A8V8TM62> , <http://purl.uniprot.org/uniprot/F8W9P4> , <http://purl.uniprot.org/uniprot/A0A8V8TNP1> , <http://purl.uniprot.org/uniprot/A0A2K8FKV1> , <http://purl.uniprot.org/uniprot/A0A8V8TML5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000171608> .

<https://identifiers.org/hgnc.symbol/KIF5B>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KIF5B" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/KIF5B> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "KIF5B" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000170759> , <https://identifiers.org/ensembl/ENSOANG00000006056> , <https://identifiers.org/ensembl/ENSSSCG00000011027> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3799> , <https://identifiers.org/ncbigene/100076805> , <https://identifiers.org/ncbigene/595132> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KIF5B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F1RWC5> , <https://identifiers.org/uniprot/A0A287A1V7> , <https://identifiers.org/uniprot/V9HW29> , <https://identifiers.org/uniprot/A0A4X1UEK6> , <https://identifiers.org/uniprot/F6PPG1> , <https://identifiers.org/uniprot/P33176> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e11a0> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F1RWC5> , <http://purl.uniprot.org/uniprot/V9HW29> , <http://purl.uniprot.org/uniprot/A0A4X1UEK6> , <http://purl.uniprot.org/uniprot/P33176> , <http://purl.uniprot.org/uniprot/A0A287A1V7> , <http://purl.uniprot.org/uniprot/F6PPG1> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/KIF5B> .

<https://identifiers.org/ensembl/ENSG00000078061>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ARAF" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000078061> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000078061" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000078061> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/369> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ARAF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A024R178> , <https://identifiers.org/uniprot/P10398> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q4653545> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dfde7> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P10398> , <http://purl.uniprot.org/uniprot/A0A024R178> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000078061> .

<https://identifiers.org/ensembl/ENSG00000141510>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TP53" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000141510> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000141510" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000141510> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7157> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TP53> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A087X1Q1> , <https://identifiers.org/uniprot/E7ESS1> , <https://identifiers.org/uniprot/H2EHT1> , <https://identifiers.org/uniprot/E9PFT5> , <https://identifiers.org/uniprot/A0A0U1RQC9> , <https://identifiers.org/uniprot/E9PCY9> , <https://identifiers.org/uniprot/I3L0W9> , <https://identifiers.org/uniprot/K7PPA8> , <https://identifiers.org/uniprot/J3KP33> , <https://identifiers.org/uniprot/S4R334> , <https://identifiers.org/uniprot/A0A087WXZ1> , <https://identifiers.org/uniprot/P04637> , <https://identifiers.org/uniprot/E7EMR6> , <https://identifiers.org/uniprot/A0A087WT22> , <https://identifiers.org/uniprot/E7EQX7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14818098> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ffc98> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P04637> , <http://purl.uniprot.org/uniprot/E7EQX7> , <http://purl.uniprot.org/uniprot/E7EMR6> , <http://purl.uniprot.org/uniprot/E9PCY9> , <http://purl.uniprot.org/uniprot/E9PFT5> , <http://purl.uniprot.org/uniprot/K7PPA8> , <http://purl.uniprot.org/uniprot/S4R334> , <http://purl.uniprot.org/uniprot/A0A087WXZ1> , <http://purl.uniprot.org/uniprot/A0A087X1Q1> , <http://purl.uniprot.org/uniprot/I3L0W9> , <http://purl.uniprot.org/uniprot/A0A087WT22> , <http://purl.uniprot.org/uniprot/A0A0U1RQC9> , <http://purl.uniprot.org/uniprot/J3KP33> , <http://purl.uniprot.org/uniprot/E7ESS1> , <http://purl.uniprot.org/uniprot/H2EHT1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000141510> .

<https://identifiers.org/ensembl/ENSG00000163235>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TGFA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000163235> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000163235" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000163235> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7039> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F8WA74> , <https://identifiers.org/uniprot/P01135> , <https://identifiers.org/uniprot/F8VNR3> , <https://identifiers.org/uniprot/E7EPT6> , <https://identifiers.org/uniprot/H0Y6S5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14908037> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b4fea> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H0Y6S5> , <http://purl.uniprot.org/uniprot/F8WA74> , <http://purl.uniprot.org/uniprot/F8VNR3> , <http://purl.uniprot.org/uniprot/P01135> , <http://purl.uniprot.org/uniprot/E7EPT6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000163235> .

<https://identifiers.org/ensembl/ENSG00000143171>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RXRG" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000143171> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000143171" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000143171> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6258> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RXRG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F1D8Q7> , <https://identifiers.org/uniprot/A0A087WZ88> , <https://identifiers.org/uniprot/P48443> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031338> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/be959> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P48443> , <http://purl.uniprot.org/uniprot/F1D8Q7> , <http://purl.uniprot.org/uniprot/A0A087WZ88> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000143171> .

<https://identifiers.org/ensembl/ENSG00000100485>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SOS2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000100485> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000100485" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100485> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6655> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SOS2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q07890> , <https://identifiers.org/uniprot/A0A087X277> , <https://identifiers.org/uniprot/G3V5W3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031647> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cacda> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087X277> , <http://purl.uniprot.org/uniprot/Q07890> , <http://purl.uniprot.org/uniprot/G3V5W3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000100485> .

<https://identifiers.org/ensembl/ENSG00000142208>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "AKT1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000142208> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000142208" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000142208> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/207> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V2I6> , <https://identifiers.org/uniprot/A0A804HJM6> , <https://identifiers.org/uniprot/A0A087WY56> , <https://identifiers.org/uniprot/G3V3X1> , <https://identifiers.org/uniprot/B0LPE5> , <https://identifiers.org/uniprot/P31749> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17816452> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/bc676> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V3X1> , <http://purl.uniprot.org/uniprot/G3V2I6> , <http://purl.uniprot.org/uniprot/A0A087WY56> , <http://purl.uniprot.org/uniprot/P31749> , <http://purl.uniprot.org/uniprot/A0A804HJM6> , <http://purl.uniprot.org/uniprot/B0LPE5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000142208> .

<https://identifiers.org/ensembl/ENSG00000138798>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "EGF" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000138798> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000138798" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000138798> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1950> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EGF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01133> , <https://identifiers.org/uniprot/A0A494C018> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14864695> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a0bdd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A494C018> , <http://purl.uniprot.org/uniprot/P01133> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000138798> .

<https://identifiers.org/ensembl/ENSG00000132906>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CASP9" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000132906> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000132906" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/e4130> , <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/af454> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000132906> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/842> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CASP9> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0Y3S8> , <https://identifiers.org/uniprot/Q5JRU8> , <https://identifiers.org/uniprot/F8VWA5> , <https://identifiers.org/uniprot/Q5JRU2> , <https://identifiers.org/uniprot/H0Y6Y2> , <https://identifiers.org/uniprot/A0A087WX72> , <https://identifiers.org/uniprot/P55211> , <https://identifiers.org/uniprot/F8VVS7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14907714> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/aae4d> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b85bf> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5JRU8> , <http://purl.uniprot.org/uniprot/H0Y3S8> , <http://purl.uniprot.org/uniprot/H0Y6Y2> , <http://purl.uniprot.org/uniprot/F8VWA5> , <http://purl.uniprot.org/uniprot/P55211> , <http://purl.uniprot.org/uniprot/F8VVS7> , <http://purl.uniprot.org/uniprot/A0A087WX72> , <http://purl.uniprot.org/uniprot/Q5JRU2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000132906> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id1fc75a0a>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id1fc75a0a> .

<https://identifiers.org/wikipathways/WP45>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "G1 to S progression" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP45> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP45" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/aa0d6> ;
        foaf:page           <https://www.wikipathways.org/instance/WP45> .

<https://identifiers.org/ensembl/ENSG00000110092>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CCND1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000110092> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000110092" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id531ac1cd> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000110092> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CCND1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5H437> , <https://identifiers.org/uniprot/P24385> , <https://identifiers.org/uniprot/Q6FI00> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15311861> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d4031> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ee43a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q6FI00> , <http://purl.uniprot.org/uniprot/P24385> , <http://purl.uniprot.org/uniprot/F5H437> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000110092> .

<https://identifiers.org/ensembl/ENSG00000117020>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000117020> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000117020" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000117020> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10000> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A5F9ZGY0> , <https://identifiers.org/uniprot/A0A5F9ZHU3> , <https://identifiers.org/uniprot/A0A5K1VW74> , <https://identifiers.org/uniprot/A0A5F9ZGZ4> , <https://identifiers.org/uniprot/A0A7P0T872> , <https://identifiers.org/uniprot/A0A5F9ZHA9> , <https://identifiers.org/uniprot/A0A7P0T8T9> , <https://identifiers.org/uniprot/A0A7P0TBJ6> , <https://identifiers.org/uniprot/A0A7P0TB29> , <https://identifiers.org/uniprot/Q9Y243> , <https://identifiers.org/uniprot/A0A7P0TB32> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18034943> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a2ca5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A5F9ZHU3> , <http://purl.uniprot.org/uniprot/Q9Y243> , <http://purl.uniprot.org/uniprot/A0A5K1VW74> , <http://purl.uniprot.org/uniprot/A0A5F9ZGY0> , <http://purl.uniprot.org/uniprot/A0A5F9ZHA9> , <http://purl.uniprot.org/uniprot/A0A7P0TBJ6> , <http://purl.uniprot.org/uniprot/A0A7P0TB32> , <http://purl.uniprot.org/uniprot/A0A5F9ZGZ4> , <http://purl.uniprot.org/uniprot/A0A7P0TB29> , <http://purl.uniprot.org/uniprot/A0A7P0T8T9> , <http://purl.uniprot.org/uniprot/A0A7P0T872> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000117020> .

<https://identifiers.org/chebi/CHEBI:29108>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ca²⁺" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:29108> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:29108" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29108> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/266> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000464> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00076> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID271> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q23905776> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ce6e9> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29108> .

<https://identifiers.org/pmc/PMC9114890>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC9114890" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4255> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9114890> .

<https://identifiers.org/ensembl/ENSG00000168610>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "STAT3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000168610> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000168610" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000168610> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6774> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STAT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V444> , <https://identifiers.org/uniprot/A0A7I2V552> , <https://identifiers.org/uniprot/A0A7I2YQI1> , <https://identifiers.org/uniprot/A0A7I2V4F6> , <https://identifiers.org/uniprot/A0A7I2V4R2> , <https://identifiers.org/uniprot/A0A7I2V4C8> , <https://identifiers.org/uniprot/G8JLH9> , <https://identifiers.org/uniprot/A0A7I2V395> , <https://identifiers.org/uniprot/A0A7I2V3V0> , <https://identifiers.org/uniprot/A0A7I2V5N9> , <https://identifiers.org/uniprot/P40763> , <https://identifiers.org/uniprot/A0A7I2V2T1> , <https://identifiers.org/uniprot/A0A7I2V4R3> , <https://identifiers.org/uniprot/A0A7I2V2G1> , <https://identifiers.org/uniprot/A0A7I2YQR5> , <https://identifiers.org/uniprot/A0A7I2YQD2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14912019> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f6482> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2YQI1> , <http://purl.uniprot.org/uniprot/P40763> , <http://purl.uniprot.org/uniprot/A0A7I2V552> , <http://purl.uniprot.org/uniprot/A0A7I2V444> , <http://purl.uniprot.org/uniprot/A0A7I2YQD2> , <http://purl.uniprot.org/uniprot/A0A7I2V4R2> , <http://purl.uniprot.org/uniprot/A0A7I2V3V0> , <http://purl.uniprot.org/uniprot/A0A7I2V2G1> , <http://purl.uniprot.org/uniprot/A0A7I2V395> , <http://purl.uniprot.org/uniprot/A0A7I2V4C8> , <http://purl.uniprot.org/uniprot/A0A7I2V5N9> , <http://purl.uniprot.org/uniprot/A0A7I2YQR5> , <http://purl.uniprot.org/uniprot/A0A7I2V4R3> , <http://purl.uniprot.org/uniprot/A0A7I2V2T1> , <http://purl.uniprot.org/uniprot/A0A7I2V4F6> , <http://purl.uniprot.org/uniprot/G8JLH9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000168610> .

<https://identifiers.org/ensembl/ENSG00000135446>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CDK4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000135446> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000135446" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135446> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1019> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDK4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q96BE9> , <https://identifiers.org/uniprot/F8VYY1> , <https://identifiers.org/uniprot/F8VTV8> , <https://identifiers.org/uniprot/F8VZ51> , <https://identifiers.org/uniprot/F8VWX7> , <https://identifiers.org/uniprot/P11802> , <https://identifiers.org/uniprot/F8VYH9> , <https://identifiers.org/uniprot/F8W1L8> , <https://identifiers.org/uniprot/F8VZ13> , <https://identifiers.org/uniprot/F8VZZ0> , <https://identifiers.org/uniprot/F8VXD2> , <https://identifiers.org/uniprot/A0A024RBB6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911754> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/fc7cd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F8VZ51> , <http://purl.uniprot.org/uniprot/F8W1L8> , <http://purl.uniprot.org/uniprot/F8VYH9> , <http://purl.uniprot.org/uniprot/F8VYY1> , <http://purl.uniprot.org/uniprot/F8VTV8> , <http://purl.uniprot.org/uniprot/F8VWX7> , <http://purl.uniprot.org/uniprot/Q96BE9> , <http://purl.uniprot.org/uniprot/P11802> , <http://purl.uniprot.org/uniprot/F8VZ13> , <http://purl.uniprot.org/uniprot/F8VZZ0> , <http://purl.uniprot.org/uniprot/F8VXD2> , <http://purl.uniprot.org/uniprot/A0A024RBB6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000135446> .

<https://identifiers.org/ensembl/ENSG00000126561>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "STAT5A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000126561> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000126561" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000126561> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6776> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STAT5A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2YQF1> , <https://identifiers.org/uniprot/A0A7I2YQY3> , <https://identifiers.org/uniprot/P42229> , <https://identifiers.org/uniprot/K7EK35> , <https://identifiers.org/uniprot/A0A7I2V380> , <https://identifiers.org/uniprot/K7EIF9> , <https://identifiers.org/uniprot/A0A384N5W4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031751> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a1058> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A384N5W4> , <http://purl.uniprot.org/uniprot/A0A7I2V380> , <http://purl.uniprot.org/uniprot/A0A7I2YQY3> , <http://purl.uniprot.org/uniprot/A0A7I2YQF1> , <http://purl.uniprot.org/uniprot/K7EIF9> , <http://purl.uniprot.org/uniprot/P42229> , <http://purl.uniprot.org/uniprot/K7EK35> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000126561> .

<https://identifiers.org/pubmed/23322901>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "23322901" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id560a2d23> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/23322901> .

<https://identifiers.org/chebi/CHEBI:90227>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Selumetinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/CYOHGALHFOKKQC-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:90227> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:90227" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/28675058> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:90227> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/8303141> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304858> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/CYOHGALHFOKKQC-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID10127622> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q7448840> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e5e99> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:90227> .

<https://identifiers.org/hgnc.symbol/PDPK1>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PDPK1" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/PDPK1> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "PDPK1" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id15d33a28> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000140992> , <https://identifiers.org/ensembl/ENSMMUG00000011459> , <https://identifiers.org/ensembl/ENSSSCG00000037719> , <https://identifiers.org/ensembl/ENSOANG00000002330> , <https://identifiers.org/ensembl/ENSBTAG00000034436> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/100089083> , <https://identifiers.org/ncbigene/100138102> , <https://identifiers.org/ncbigene/5170> , <https://identifiers.org/ncbigene/100192445> , <https://identifiers.org/ncbigene/697523> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PDPK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F1SUH3> , <https://identifiers.org/uniprot/A0A4X1VU11> , <https://identifiers.org/uniprot/H3BPW1> , <https://identifiers.org/uniprot/A0A5G2R5E7> , <https://identifiers.org/uniprot/A0A4X1VUK9> , <https://identifiers.org/uniprot/O15530> , <https://identifiers.org/uniprot/F1MQJ7> , <https://identifiers.org/uniprot/A0A5G2QD73> , <https://identifiers.org/uniprot/H9ESX9> , <https://identifiers.org/uniprot/A0A287AST6> , <https://identifiers.org/uniprot/F6YZV2> , <https://identifiers.org/uniprot/H3BPR5> , <https://identifiers.org/uniprot/A0A1D5RKG7> , <https://identifiers.org/uniprot/H3BQ10> , <https://identifiers.org/uniprot/F7B364> , <https://identifiers.org/uniprot/A0A8D1MFA9> , <https://identifiers.org/uniprot/A0A5G2QWA6> , <https://identifiers.org/uniprot/A0A286ZV67> , <https://identifiers.org/uniprot/H3BQA3> , <https://identifiers.org/uniprot/E9PER6> , <https://identifiers.org/uniprot/A0A8D2BVM8> , <https://identifiers.org/uniprot/A0A5G2QJE8> , <https://identifiers.org/uniprot/H3BNV5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cb3f3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A1D5RKG7> , <http://purl.uniprot.org/uniprot/H9ESX9> , <http://purl.uniprot.org/uniprot/A0A5G2QD73> , <http://purl.uniprot.org/uniprot/A0A5G2R5E7> , <http://purl.uniprot.org/uniprot/H3BPR5> , <http://purl.uniprot.org/uniprot/E9PER6> , <http://purl.uniprot.org/uniprot/F1MQJ7> , <http://purl.uniprot.org/uniprot/F1SUH3> , <http://purl.uniprot.org/uniprot/A0A8D1MFA9> , <http://purl.uniprot.org/uniprot/H3BQ10> , <http://purl.uniprot.org/uniprot/H3BPW1> , <http://purl.uniprot.org/uniprot/A0A287AST6> , <http://purl.uniprot.org/uniprot/A0A4X1VU11> , <http://purl.uniprot.org/uniprot/A0A5G2QWA6> , <http://purl.uniprot.org/uniprot/F6YZV2> , <http://purl.uniprot.org/uniprot/F7B364> , <http://purl.uniprot.org/uniprot/A0A5G2QJE8> , <http://purl.uniprot.org/uniprot/A0A286ZV67> , <http://purl.uniprot.org/uniprot/A0A8D2BVM8> , <http://purl.uniprot.org/uniprot/H3BNV5> , <http://purl.uniprot.org/uniprot/H3BQA3> , <http://purl.uniprot.org/uniprot/A0A4X1VUK9> , <http://purl.uniprot.org/uniprot/O15530> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/PDPK1> .

<https://identifiers.org/pubmed/25514926>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "25514926" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/25514926> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/af454>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/af454> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000132906> , <https://identifiers.org/ensembl/ENSG00000172115> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000172115> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000132906> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id560a2d23>
        rdf:type            wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/23322901> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id560a2d23> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:6067> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:6067> ;
        wp:target           <https://identifiers.org/chebi/CHEBI:6067> .

<https://identifiers.org/hgnc.symbol/VEGFR2>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "VEGFR" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/VEGFR2> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "VEGFR2" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idc5593e8> ;
        dcterms:references  <https://identifiers.org/pubmed/19629074> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/VEGFR2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d0c10> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/VEGFR2> .

<https://identifiers.org/ensembl/ENSG00000172115>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CYCS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000172115> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000172115" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/af454> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/a9afe> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000172115> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/54205> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYCS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JFR7> , <https://identifiers.org/uniprot/P99999> , <https://identifiers.org/uniprot/G4XXL9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14819361> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ba305> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P99999> , <http://purl.uniprot.org/uniprot/G4XXL9> , <http://purl.uniprot.org/uniprot/C9JFR7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000172115> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id3782c246>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id3782c246> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000068028> , <https://identifiers.org/ensembl/ENSG00000266094> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id1bbfd20d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/id1bbfd20d> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000101109> , <https://identifiers.org/ensembl/ENSG00000266094> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000266094> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000101109> .

<https://identifiers.org/hmdb/HMDB0304845>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Sotorasib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/NXQKSXLFSAEQCZ-SFHVURJKSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0304845> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0304845" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idfe3b52ac> ;
        dcterms:references  <https://identifiers.org/pubmed/38375734> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:178199> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/72380148> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304845> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/NXQKSXLFSAEQCZ-SFHVURJKSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID137278711> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q75175937> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d89d6> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0304845> .

<https://identifiers.org/pubmed/34118197>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "34118197" ;
        dcterms:isPartOf    <https://identifiers.org/hmdb/HMDB0304855> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/34118197> .

<https://identifiers.org/ensembl/ENSG00000116717>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GADD45A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000116717> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000116717" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000116717> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1647> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GADD45A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P24522> , <https://identifiers.org/uniprot/A0A3B3ITF9> , <https://identifiers.org/uniprot/A0A087WZQ0> , <https://identifiers.org/uniprot/A5JUZ3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17913576> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b4419> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P24522> , <http://purl.uniprot.org/uniprot/A5JUZ3> , <http://purl.uniprot.org/uniprot/A0A087WZQ0> , <http://purl.uniprot.org/uniprot/A0A3B3ITF9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000116717> .

<https://identifiers.org/hgnc.symbol/KIF5A>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KIF5A" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/KIF5A> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "KIF5A" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/29128428> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSOANG00000046887> , <https://identifiers.org/ensembl/ENSG00000155980> , <https://identifiers.org/ensembl/ENSSSCG00000000439> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3798> , <https://identifiers.org/ncbigene/100519957> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KIF5A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A6Q8PH72> , <https://identifiers.org/uniprot/A0A6Q8PGG7> , <https://identifiers.org/uniprot/A0A287BQM1> , <https://identifiers.org/uniprot/A0A6Q8PHA9> , <https://identifiers.org/uniprot/A0A6Q8PGP0> , <https://identifiers.org/uniprot/A0A6Q8PEZ8> , <https://identifiers.org/uniprot/A0A4X1W0B5> , <https://identifiers.org/uniprot/A0A286ZIR2> , <https://identifiers.org/uniprot/I3LTF9> , <https://identifiers.org/uniprot/A0A6Q8PFB8> , <https://identifiers.org/uniprot/A0A6Q8PFR6> , <https://identifiers.org/uniprot/A0A287B7W7> , <https://identifiers.org/uniprot/A0A8D1C9Q8> , <https://identifiers.org/uniprot/A0A6Q8PGT2> , <https://identifiers.org/uniprot/A0A6Q8PFQ3> , <https://identifiers.org/uniprot/A0A6Q8PFG5> , <https://identifiers.org/uniprot/A0A6Q8PFD6> , <https://identifiers.org/uniprot/A0A6Q8PGN1> , <https://identifiers.org/uniprot/Q12840> , <https://identifiers.org/uniprot/A0A6Q8PFV6> , <https://identifiers.org/uniprot/F1SKH3> , <https://identifiers.org/uniprot/J3KNA1> , <https://identifiers.org/uniprot/A0A6Q8PGJ3> , <https://identifiers.org/uniprot/A0A4X1W599> , <https://identifiers.org/uniprot/A0A6Q8PH74> , <https://identifiers.org/uniprot/A0A6Q8PH22> , <https://identifiers.org/uniprot/A0A6Q8PGP8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/e7068> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A4X1W0B5> , <http://purl.uniprot.org/uniprot/A0A286ZIR2> , <http://purl.uniprot.org/uniprot/J3KNA1> , <http://purl.uniprot.org/uniprot/A0A6Q8PH72> , <http://purl.uniprot.org/uniprot/A0A287BQM1> , <http://purl.uniprot.org/uniprot/A0A6Q8PGP0> , <http://purl.uniprot.org/uniprot/A0A6Q8PEZ8> , <http://purl.uniprot.org/uniprot/A0A6Q8PFD6> , <http://purl.uniprot.org/uniprot/A0A6Q8PGP8> , <http://purl.uniprot.org/uniprot/A0A6Q8PGT2> , <http://purl.uniprot.org/uniprot/I3LTF9> , <http://purl.uniprot.org/uniprot/A0A6Q8PGN1> , <http://purl.uniprot.org/uniprot/A0A6Q8PHA9> , <http://purl.uniprot.org/uniprot/A0A6Q8PGG7> , <http://purl.uniprot.org/uniprot/F1SKH3> , <http://purl.uniprot.org/uniprot/A0A4X1W599> , <http://purl.uniprot.org/uniprot/A0A6Q8PFG5> , <http://purl.uniprot.org/uniprot/A0A6Q8PH22> , <http://purl.uniprot.org/uniprot/A0A6Q8PFR6> , <http://purl.uniprot.org/uniprot/A0A287B7W7> , <http://purl.uniprot.org/uniprot/A0A6Q8PH74> , <http://purl.uniprot.org/uniprot/A0A6Q8PFQ3> , <http://purl.uniprot.org/uniprot/A0A6Q8PFB8> , <http://purl.uniprot.org/uniprot/A0A6Q8PGJ3> , <http://purl.uniprot.org/uniprot/A0A8D1C9Q8> , <http://purl.uniprot.org/uniprot/Q12840> , <http://purl.uniprot.org/uniprot/A0A6Q8PFV6> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/KIF5A> .

<https://identifiers.org/ensembl/ENSG00000134574>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "DDB2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000134574> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000134574" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000134574> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1643> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DDB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A087WYT8> , <https://identifiers.org/uniprot/A0A087WTQ7> , <https://identifiers.org/uniprot/A0A087WV56> , <https://identifiers.org/uniprot/A0A087WW71> , <https://identifiers.org/uniprot/Q92466> , <https://identifiers.org/uniprot/A0A087X0X5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17913462> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b09ef> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087WYT8> , <http://purl.uniprot.org/uniprot/A0A087X0X5> , <http://purl.uniprot.org/uniprot/A0A087WV56> , <http://purl.uniprot.org/uniprot/A0A087WW71> , <http://purl.uniprot.org/uniprot/Q92466> , <http://purl.uniprot.org/uniprot/A0A087WTQ7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000134574> .

<https://identifiers.org/chebi/CHEBI:75045>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Dabrafenib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BFSMGDJOXZAERB-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:75045> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:75045" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/29438093> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:75045> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/25948204> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0250818> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BFSMGDJOXZAERB-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID44462760> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q3011604> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dd8da> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:75045> .

<https://identifiers.org/wikipathways/WP179>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "Cell cycle" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP179> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP179" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/ef039> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/a7484> ;
        foaf:page           <https://www.wikipathways.org/instance/WP179> .

<https://identifiers.org/pubmed/15948711>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "15948711" ;
        dcterms:isPartOf    <https://identifiers.org/ensembl/ENSG00000266094> , <https://identifiers.org/ensembl/ENSG00000101109> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/15948711> .

<https://identifiers.org/ensembl/ENSG00000115904>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SOS1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000115904> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000115904" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115904> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6654> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SOS1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q07889> , <https://identifiers.org/uniprot/A0A8I5KP47> , <https://identifiers.org/uniprot/G5E9C8> , <https://identifiers.org/uniprot/A0A8I5QJD1> , <https://identifiers.org/uniprot/A0A8I5KV97> , <https://identifiers.org/uniprot/A0A8I5QJ77> , <https://identifiers.org/uniprot/A0A8I5KY52> , <https://identifiers.org/uniprot/A0A8I5KWL0> , <https://identifiers.org/uniprot/C9K0N6> , <https://identifiers.org/uniprot/A0A8I5QJF3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14908123> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f6ace> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5QJF3> , <http://purl.uniprot.org/uniprot/C9K0N6> , <http://purl.uniprot.org/uniprot/A0A8I5QJ77> , <http://purl.uniprot.org/uniprot/Q07889> , <http://purl.uniprot.org/uniprot/A0A8I5KWL0> , <http://purl.uniprot.org/uniprot/G5E9C8> , <http://purl.uniprot.org/uniprot/A0A8I5KV97> , <http://purl.uniprot.org/uniprot/A0A8I5KP47> , <http://purl.uniprot.org/uniprot/A0A8I5KY52> , <http://purl.uniprot.org/uniprot/A0A8I5QJD1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000115904> .

<https://identifiers.org/ensembl/ENSG00000102882>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000102882> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000102882" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102882> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YEX6> , <https://identifiers.org/uniprot/E9PBK7> , <https://identifiers.org/uniprot/L7RXH5> , <https://identifiers.org/uniprot/B3KR49> , <https://identifiers.org/uniprot/P27361> , <https://identifiers.org/uniprot/H0YDH9> , <https://identifiers.org/uniprot/E9PRH7> , <https://identifiers.org/uniprot/E9PQW4> , <https://identifiers.org/uniprot/E9PJF0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15328839> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dafc8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PQW4> , <http://purl.uniprot.org/uniprot/L7RXH5> , <http://purl.uniprot.org/uniprot/H0YEX6> , <http://purl.uniprot.org/uniprot/H0YDH9> , <http://purl.uniprot.org/uniprot/E9PJF0> , <http://purl.uniprot.org/uniprot/E9PBK7> , <http://purl.uniprot.org/uniprot/P27361> , <http://purl.uniprot.org/uniprot/B3KR49> , <http://purl.uniprot.org/uniprot/E9PRH7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000102882> .

<https://identifiers.org/ensembl/ENSG00000197943>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCG2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000197943> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000197943" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000197943> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5336> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCG2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TL51> , <https://identifiers.org/uniprot/H3BPZ3> , <https://identifiers.org/uniprot/A0A8V8TMP2> , <https://identifiers.org/uniprot/A0A8V8TLH5> , <https://identifiers.org/uniprot/P16885> , <https://identifiers.org/uniprot/A0A8V8TL55> , <https://identifiers.org/uniprot/A0A8V8TLG6> , <https://identifiers.org/uniprot/A0A8V8TMG4> , <https://identifiers.org/uniprot/A0A8V8TMQ0> , <https://identifiers.org/uniprot/H3BMT7> , <https://identifiers.org/uniprot/A0A8V8TL29> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030586> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/bb23c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TMG4> , <http://purl.uniprot.org/uniprot/A0A8V8TL29> , <http://purl.uniprot.org/uniprot/A0A8V8TL55> , <http://purl.uniprot.org/uniprot/H3BMT7> , <http://purl.uniprot.org/uniprot/A0A8V8TMP2> , <http://purl.uniprot.org/uniprot/H3BPZ3> , <http://purl.uniprot.org/uniprot/A0A8V8TL51> , <http://purl.uniprot.org/uniprot/A0A8V8TLH5> , <http://purl.uniprot.org/uniprot/A0A8V8TMQ0> , <http://purl.uniprot.org/uniprot/P16885> , <http://purl.uniprot.org/uniprot/A0A8V8TLG6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000197943> .

<https://identifiers.org/ensembl/ENSG00000164305>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CASP3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000164305> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000164305" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/e4130> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000164305> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/836> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CASP3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TPU5> , <https://identifiers.org/uniprot/A8MVM1> , <https://identifiers.org/uniprot/C9JXR7> , <https://identifiers.org/uniprot/P42574> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14914370> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d88fd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TPU5> , <http://purl.uniprot.org/uniprot/C9JXR7> , <http://purl.uniprot.org/uniprot/A8MVM1> , <http://purl.uniprot.org/uniprot/P42574> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000164305> .

<https://identifiers.org/hgnc.symbol/HGF>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "HGF" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/HGF> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "HGF" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id3fb0862b> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSOANG00000003484> , <https://identifiers.org/ensembl/ENSG00000019991> , <https://identifiers.org/ensembl/ENSSSCG00000015403> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/100074892> , <https://identifiers.org/ncbigene/100525120> , <https://identifiers.org/ncbigene/3082> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HGF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A480SZ19> , <https://identifiers.org/uniprot/P14210> , <https://identifiers.org/uniprot/C9JDP4> , <https://identifiers.org/uniprot/A0A4X1SJC0> , <https://identifiers.org/uniprot/C9WSJ4> , <https://identifiers.org/uniprot/F1SB93> , <https://identifiers.org/uniprot/C9WSJ3> , <https://identifiers.org/uniprot/A0A2R8YEI1> , <https://identifiers.org/uniprot/A0A5G2QP08> , <https://identifiers.org/uniprot/F7FSI1> , <https://identifiers.org/uniprot/A0A287BRN0> , <https://identifiers.org/uniprot/C9JS80> , <https://identifiers.org/uniprot/A0A8D1V5H5> , <https://identifiers.org/uniprot/F7FSH7> , <https://identifiers.org/uniprot/A0A8D1PS51> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d73ec> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A4X1SJC0> , <http://purl.uniprot.org/uniprot/F7FSI1> , <http://purl.uniprot.org/uniprot/A0A480SZ19> , <http://purl.uniprot.org/uniprot/C9JDP4> , <http://purl.uniprot.org/uniprot/F1SB93> , <http://purl.uniprot.org/uniprot/P14210> , <http://purl.uniprot.org/uniprot/A0A8D1V5H5> , <http://purl.uniprot.org/uniprot/C9WSJ3> , <http://purl.uniprot.org/uniprot/A0A5G2QP08> , <http://purl.uniprot.org/uniprot/A0A2R8YEI1> , <http://purl.uniprot.org/uniprot/A0A287BRN0> , <http://purl.uniprot.org/uniprot/C9JS80> , <http://purl.uniprot.org/uniprot/C9WSJ4> , <http://purl.uniprot.org/uniprot/F7FSH7> , <http://purl.uniprot.org/uniprot/A0A8D1PS51> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/HGF> .

<https://identifiers.org/hgnc.symbol/GRB2>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GRB2" ;
        dc:identifier       <https://identifiers.org/hgnc.symbol/GRB2> ;
        dc:source           "HGNC" ;
        dcterms:identifier  "GRB2" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/e1eea> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000177885> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2885> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GRB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3QLF6> , <https://identifiers.org/uniprot/P62993> , <https://identifiers.org/uniprot/B0LPF3> , <https://identifiers.org/uniprot/J3KT38> , <https://identifiers.org/uniprot/J3QRL5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/c12ca> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P62993> , <http://purl.uniprot.org/uniprot/B0LPF3> , <http://purl.uniprot.org/uniprot/J3QLF6> , <http://purl.uniprot.org/uniprot/J3KT38> , <http://purl.uniprot.org/uniprot/J3QRL5> ;
        foaf:page           <https://www.genenames.org/data/gene-symbol-report/#!/symbol/GRB2> .

<https://identifiers.org/hmdb/HMDB0304865>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Selpercatinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XIIOFHFUYBLOLW-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0304865> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0304865" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/39983053> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/72379991> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0304865> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XIIOFHFUYBLOLW-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID134436906> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q96405266> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/f3a83> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0304865> .

<https://identifiers.org/ensembl/ENSG00000132155>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RAF1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000132155> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000132155" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000132155> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5894> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RAF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KSM4> , <https://identifiers.org/uniprot/A0A8I5KWS9> , <https://identifiers.org/uniprot/A0A8I5KQV4> , <https://identifiers.org/uniprot/A0A8I5KSB0> , <https://identifiers.org/uniprot/A0A8I5KTK4> , <https://identifiers.org/uniprot/A0A8I5KSV6> , <https://identifiers.org/uniprot/P04049> , <https://identifiers.org/uniprot/H7C155> , <https://identifiers.org/uniprot/A0A8I5KYC4> , <https://identifiers.org/uniprot/A0A8I5KR46> , <https://identifiers.org/uniprot/A0A8I5KWA9> , <https://identifiers.org/uniprot/A0A8I5QJG5> , <https://identifiers.org/uniprot/A0A8I5KS16> , <https://identifiers.org/uniprot/A0A8I5KSI1> , <https://identifiers.org/uniprot/A0A8I5KTA5> , <https://identifiers.org/uniprot/A0A0B4J1W9> , <https://identifiers.org/uniprot/A0A8I5QKZ6> , <https://identifiers.org/uniprot/A0A8I5KW44> , <https://identifiers.org/uniprot/A0A8I5KRD1> , <https://identifiers.org/uniprot/A0A8I5QKU8> , <https://identifiers.org/uniprot/L7RRS6> , <https://identifiers.org/uniprot/A0A8I5KQ33> , <https://identifiers.org/uniprot/A0A0S2Z559> , <https://identifiers.org/uniprot/A0A8I5KYP5> , <https://identifiers.org/uniprot/A0A8I5KWF7> , <https://identifiers.org/uniprot/A0A8I5KUW4> , <https://identifiers.org/uniprot/A0A8I5KT32> , <https://identifiers.org/uniprot/A0A8I5KX50> , <https://identifiers.org/uniprot/A0A0S2Z4L5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14903573> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/d3f2c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KTK4> , <http://purl.uniprot.org/uniprot/A0A8I5KQ33> , <http://purl.uniprot.org/uniprot/A0A8I5QKZ6> , <http://purl.uniprot.org/uniprot/A0A8I5KYP5> , <http://purl.uniprot.org/uniprot/H7C155> , <http://purl.uniprot.org/uniprot/A0A8I5KSI1> , <http://purl.uniprot.org/uniprot/A0A8I5KWA9> , <http://purl.uniprot.org/uniprot/A0A0S2Z559> , <http://purl.uniprot.org/uniprot/A0A8I5KSM4> , <http://purl.uniprot.org/uniprot/A0A8I5KSV6> , <http://purl.uniprot.org/uniprot/A0A8I5KWF7> , <http://purl.uniprot.org/uniprot/A0A8I5KUW4> , <http://purl.uniprot.org/uniprot/A0A8I5QJG5> , <http://purl.uniprot.org/uniprot/A0A0S2Z4L5> , <http://purl.uniprot.org/uniprot/A0A0B4J1W9> , <http://purl.uniprot.org/uniprot/L7RRS6> , <http://purl.uniprot.org/uniprot/A0A8I5KYC4> , <http://purl.uniprot.org/uniprot/A0A8I5KS16> , <http://purl.uniprot.org/uniprot/P04049> , <http://purl.uniprot.org/uniprot/A0A8I5KTA5> , <http://purl.uniprot.org/uniprot/A0A8I5KRD1> , <http://purl.uniprot.org/uniprot/A0A8I5KT32> , <http://purl.uniprot.org/uniprot/A0A8I5QKU8> , <http://purl.uniprot.org/uniprot/A0A8I5KWS9> , <http://purl.uniprot.org/uniprot/A0A8I5KSB0> , <http://purl.uniprot.org/uniprot/A0A8I5KR46> , <http://purl.uniprot.org/uniprot/A0A8I5KX50> , <http://purl.uniprot.org/uniprot/A0A8I5KW44> , <http://purl.uniprot.org/uniprot/A0A8I5KQV4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000132155> .

<https://identifiers.org/chebi/CHEBI:6067>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Retinoic acid" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/SHGAZHPCJJPHSC-XFYACQKRSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:6067> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:6067" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/id560a2d23> , <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:6067> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4445539> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0006219> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/SHGAZHPCJJPHSC-XFYACQKRSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C07058> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMPR01090021> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5282379> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q287029> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dbe52> , <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/cc06f> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMPR01090021> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6067> .

<https://identifiers.org/hmdb/HMDB0248129>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Alectinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/KDGFLJKFZUIJMX-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0248129> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0248129" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        dcterms:references  <https://identifiers.org/pubmed/38375734> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:90936> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/26326738> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0248129> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/KDGFLJKFZUIJMX-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID49806720> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q21099132> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/dd28d> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0248129> .

<https://identifiers.org/ensembl/ENSG00000112242>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "E2F3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000112242> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000112242" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000112242> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1871> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/E2F3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O00716> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17915118> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/df980> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O00716> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000112242> .

<https://identifiers.org/ensembl/ENSG00000124181>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLCG1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000124181> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000124181" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000124181> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5335> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCG1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/V9GY63> , <https://identifiers.org/uniprot/M0QX77> , <https://identifiers.org/uniprot/V9GYH5> , <https://identifiers.org/uniprot/P19174> , <https://identifiers.org/uniprot/A0A0D9SEK2> , <https://identifiers.org/uniprot/V9GY71> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030585> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4255_r142399/DataNode/b644b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/V9GYH5> , <http://purl.uniprot.org/uniprot/V9GY71> , <http://purl.uniprot.org/uniprot/A0A0D9SEK2> , <http://purl.uniprot.org/uniprot/P19174> , <http://purl.uniprot.org/uniprot/M0QX77> , <http://purl.uniprot.org/uniprot/V9GY63> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000124181> .

<http://rdf.wikipathways.org/Pathway/WP4255_r142399/WP/Interaction/idfe3b52ac>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4255_r142399> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4255_r142399/Interaction/idfe3b52ac> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000133703> , <https://identifiers.org/hmdb/HMDB0304845> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0304845> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000133703> .

<https://identifiers.org/pubmed/38375734>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "38375734" ;
        dcterms:isPartOf    <https://identifiers.org/hmdb/HMDB0254164> , <https://identifiers.org/hmdb/HMDB0249380> , <https://identifiers.org/hmdb/HMDB0248129> , <https://identifiers.org/hmdb/HMDB0249821> , <https://identifiers.org/hmdb/HMDB0304845> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/38375734> .
