@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/wikipathways/WP92>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "de novo biosynthesis of  pyrimidine ribonucleotides" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP92> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP92" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/id22afc2bd> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/e41f5> ;
        foaf:page           <https://www.wikipathways.org/instance/WP92> .

<https://identifiers.org/cas/372-75-8>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "citrulline" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/RHGKLRLOHDJJDR-BYPYZUCNSA-N> ;
        dc:identifier       <https://identifiers.org/cas/372-75-8> ;
        dc:source           "CAS" ;
        dcterms:identifier  "372-75-8" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16349> , <https://identifiers.org/chebi/CHEBI:57743> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/9367> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000904> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/RHGKLRLOHDJJDR-BYPYZUCNSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00327> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9750> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6992098> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q408641> , <http://www.wikidata.org/entity/Q106345633> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/cee> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=372-75-8> .

<https://identifiers.org/chebi/CHEBI:15377>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "H₂O" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XLYOFNOQVPJJNP-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15377> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "15377" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15377> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/937> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0002111> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XLYOFNOQVPJJNP-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00001> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID962> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID22247451> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q283> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/b043f> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/c55a8> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=15377> .

<https://identifiers.org/sgd/S000005829>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CPA1" ;
        dc:identifier       <https://identifiers.org/sgd/S000005829> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000005829" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YOR303W> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/854479> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P07258> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/c6832> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P07258> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000005829> .

<http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/id22afc2bd>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP275_r140629/Interaction/id22afc2bd> ;
        wp:participants   <https://identifiers.org/wikipathways/WP92> , <https://identifiers.org/chebi/CHEBI:58228> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:58228> ;
        wp:target         <https://identifiers.org/wikipathways/WP92> .

<http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/idb9ed8e4c>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP275_r140629/Interaction/idb9ed8e4c> ;
        wp:participants   <https://identifiers.org/cas/56-86-0> , <https://identifiers.org/wikipathways/WP191> ;
        wp:source         <https://identifiers.org/wikipathways/WP191> ;
        wp:target         <https://identifiers.org/cas/56-86-0> .

<https://identifiers.org/cas/58-64-0>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "ADP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XTWYTFMLZFPYCI-KQYNXXCUSA-N> ;
        dc:identifier       <https://identifiers.org/cas/58-64-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "58-64-0" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16761> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5800> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001341> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XTWYTFMLZFPYCI-KQYNXXCUSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00008> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6022> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q185253> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/ddba4> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/a2e> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=58-64-0> .

<https://identifiers.org/cas/70-26-8>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "L-ornithine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/AHLPHDHHMVZTML-BYPYZUCNSA-N> ;
        dc:identifier       <https://identifiers.org/cas/70-26-8> ;
        dc:source           "CAS" ;
        dcterms:identifier  "70-26-8" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15729> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/6026> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000214> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/AHLPHDHHMVZTML-BYPYZUCNSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00077> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6262> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID88747248> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q410198> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/c0c> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=70-26-8> .

obo:NCBITaxon_4932  obo:NCIT_C179773  "4932" .

<https://identifiers.org/cas/2466-09-3>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "pyrophosphate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XPPKVPWEQAFLFU-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/cas/2466-09-3> ;
        dc:source           "CAS" ;
        dcterms:identifier  "2466-09-3" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29888> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/996> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000250> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XPPKVPWEQAFLFU-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00013> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID21961011> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1023> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q411092> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/e7d> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=2466-09-3> .

<https://identifiers.org/chebi/CHEBI:57805>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "N-alpha-acetylornithine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/JRLGPAXAGHMNOL-LURJTMIESA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:57805> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "57805" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/id5941ffc5> , <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:57805> , <https://identifiers.org/chebi/CHEBI:16543> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388369> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0003357> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/JRLGPAXAGHMNOL-LURJTMIESA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00437> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439232> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6992102> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q26690116> , <http://www.wikidata.org/entity/Q106345492> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/ed359> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=57805> .

<https://identifiers.org/chebi/CHEBI:30616>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "ATP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZKHQWZAMYRWXGA-KQYNXXCUSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:30616> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "30616" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:30616> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4574455> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ZKHQWZAMYRWXGA-KQYNXXCUSA-J> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5461108> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27113900> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/b2ab8> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=30616> .

<https://identifiers.org/sgd/S000001060>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ARG4" ;
        dc:identifier       <https://identifiers.org/sgd/S000001060> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000001060" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YHR018C> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/856411> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P04076> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/a5f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P04076> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000001060> .

<https://identifiers.org/chebi/CHEBI:456215>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "AMP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/UDMBCSSLTHHNCD-KQYNXXCUSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:456215> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "456215" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:456215> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/10239183> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/UDMBCSSLTHHNCD-KQYNXXCUSA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID15938965> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27225747> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/ce95c> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=456215> .

<https://identifiers.org/chebi/CHEBI:58359>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "L-glutamine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZDXPYRJPNDTMRX-VKHMYHEASA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:58359> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "58359" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:58359> , <https://identifiers.org/chebi/CHEBI:18050> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5746> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000641> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ZDXPYRJPNDTMRX-VKHMYHEASA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00064> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5961> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6992086> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q181619> , <http://www.wikidata.org/entity/Q106345471> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/fb4da> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=58359> .

<https://identifiers.org/sgd/S000003870>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CPA2" ;
        dc:identifier       <https://identifiers.org/sgd/S000003870> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000003870" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YJR109C> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/853573> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P03965> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/b4dae> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P03965> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000003870> .

<https://identifiers.org/wikipathways/WP191>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "glutamate biosynthesis from ammonia" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP191> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP191" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/idb9ed8e4c> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/e4f79> ;
        foaf:page           <https://www.wikipathways.org/instance/WP191> .

<https://identifiers.org/sgd/S000003607>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ARG2" ;
        dc:identifier       <https://identifiers.org/sgd/S000003607> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000003607" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YJL071W> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/853374> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P40360> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/aba> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P40360> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000003607> .

<https://identifiers.org/cas/72-89-9>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "acetyl-CoA" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZSLZBFCDCINBPY-ZSJPKINUSA-N> ;
        dc:identifier       <https://identifiers.org/cas/72-89-9> ;
        dc:source           "CAS" ;
        dcterms:identifier  "72-89-9" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15351> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/392413> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001206> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ZSLZBFCDCINBPY-ZSJPKINUSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00024> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMFA07050281> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID444493> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q715317> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/b2e> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMFA07050281> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=72-89-9> .

<https://identifiers.org/pubmed/12603335>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "12603335" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/12603335> .

<https://identifiers.org/sgd/S000000871>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ARG5,6" ;
        dc:identifier       <https://identifiers.org/sgd/S000000871> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000000871" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YER069W> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/856800> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q01217> ;
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<https://identifiers.org/pubmed/11553611>
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        dc:title               "Arginine biosynthesis"@en ;
        dcterms:description    "The first five steps of arginine biosynthesis in S. cerevisiae take place in the mitochondrion (CITS: [11553611])(CITS: [Hinnebusch]). This part of the pathway is known as the acetylated derivatives cycle because the acetyl group that is added to L-glutamate in the first step of the pathway is recycled via N-acetylglutamate generated in the fifth step. The enzymes that catalyze the second and third steps are encoded by a single gene (ARG5,6) that is translated into a pre-protein which is imported into mitochondria and cleaved there to yield two enzymes, N-acetylglutamate kinase and N-acetylglutamyl-phosphate reductase (CITS: [1649049]). These enzymes form a complex with each other and with N-acetylglutamate synthase, the first enzyme in the pathway, which may have implications for regulation of their activity (CITS: [11553611]).  The mitochondrial steps of the arginine biosynthesis pathway result in the formation of ornithine, which is exported to the cytoplasm by the transporter Ort1p (CITS: [8798783]). In the cytoplasm, L-ornithine is converted to L-arginine in three reactions mediated by ornithine carbamoyltransferase, arginosuccinate synthase, and argininosuccinate lyase.  Transcription of genes of the arginine biosynthetic pathway, as well as of other amino acid biosynthetic pathways, is activated by the transcription factor Gcn4p under conditions of amino acid starvation (CITS: [11390663])(CITS: [Hinnebusch]). Transcription of ARG1, ARG3, ARG5,6, and ARG8 is also repressed in the presence of arginine by the ArgR/Mcm1p complex, which consists of Arg80p, Arg81p, Arg82p, and Mcm1p (CITS: [14563547]). The transcriptional activator Gcn4p interacts with subunits of the ArgR/Mcm1p repressor, allowing for fine-tuning of transcriptional control in response to arginine availability (CITS: [15289616]). \nSOURCE: [SGD pathways](http://pathway.yeastgenome.org/server.html)." ;
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<https://identifiers.org/cas/1927-31-7>
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<https://identifiers.org/chebi/CHEBI:17544>
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=17544> .

<http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/id5941ffc5>
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<https://identifiers.org/sgd/S000005500>
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        foaf:page           <http://www.yeastgenome.org/locus/S000005500> .

<https://identifiers.org/sgd/S000005419>
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        owl:sameAs          <http://purl.uniprot.org/uniprot/P22768> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000005419> .

<https://identifiers.org/chebi/CHEBI:57936>
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        rdfs:label          "N-acetylglutamyl-phosphate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FCVIHFVSXHOPSW-YFKPBYRVSA-N> ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=57936> .

<https://identifiers.org/chebi/CHEBI:16810>
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        rdfs:label          "2-oxoglutarate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/KPGXRSRHYNQIFN-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:16810> ;
        dc:source           "ChEBI" ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/d1d82> ;
        owl:sameAs          <https://swisslipids.org/rdf/SLM_000389931> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16810> .

<https://identifiers.org/cas/56-86-0>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "L-glutamate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/WHUUTDBJXJRKMK-VKHMYHEASA-N> ;
        dc:identifier       <https://identifiers.org/cas/56-86-0> ;
        dc:source           "CAS" ;
        dcterms:identifier  "56-86-0" ;
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        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID33032> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID88747398> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID44272391> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/f99> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/f6a> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/be1> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=56-86-0> .

<https://identifiers.org/cas/74-79-3>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "L-arginine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ODKSFYDXXFIFQN-BYPYZUCNSA-N> ;
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        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=74-79-3> .

<https://identifiers.org/chebi/CHEBI:29123>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "N-acetylglutamate semialdehyde" ;
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        dc:identifier       <https://identifiers.org/chebi/CHEBI:29123> ;
        dc:source           "ChEBI" ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=29123> .

<https://identifiers.org/chebi/CHEBI:57472>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "L-arginino-succinate" ;
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        dc:identifier       <https://identifiers.org/chebi/CHEBI:57472> ;
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        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=57472> .

<https://identifiers.org/cas/14265-44-2>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "phosphate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/NBIIXXVUZAFLBC-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/cas/14265-44-2> ;
        dc:source           "CAS" ;
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        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=14265-44-2> .

<https://identifiers.org/chebi/CHEBI:58349>
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        rdfs:label          "NADP" ;
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<https://identifiers.org/cas/64885-97-8>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Coenzyme A" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XXFFZHQKSZLLIT-NALJQGANSA-N> ;
        dc:identifier       <https://identifiers.org/cas/64885-97-8> ;
        dc:source           "CAS" ;
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        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=64885-97-8> .

<https://identifiers.org/cas/53-57-6>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "NADPH" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ACFIXJIJDZMPPO-NNYOXOHSSA-N> ;
        dc:identifier       <https://identifiers.org/cas/53-57-6> ;
        dc:source           "CAS" ;
        dcterms:identifier  "53-57-6" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16474> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5673> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000221> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ACFIXJIJDZMPPO-NNYOXOHSSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00005> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5884> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q26841327> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/e07> ;
        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=53-57-6> .

<https://identifiers.org/chebi/CHEBI:29806>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "fumarate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/VZCYOOQTPOCHFL-OWOJBTEDSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:29806> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:29806" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29806> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4573886> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/VZCYOOQTPOCHFL-OWOJBTEDSA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5460307> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q28529698> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/ffb28> ;
        owl:sameAs          <https://swisslipids.org/rdf/SLM_000389686> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29806> .

<https://identifiers.org/chebi/CHEBI:15378>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "H⁺" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/GPRLSGONYQIRFK-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15378> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "15378" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15378> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/1010> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0059597> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/GPRLSGONYQIRFK-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00080> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1038> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q506710> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/deb4a> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/fce3e> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/ac6cf> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/a6f97> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=15378> .

<https://identifiers.org/chebi/CHEBI:58228>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "carbamoyl phosphate" , "carbamoyl-phosphate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FFQKYPRQEYGKAF-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:58228> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "58228" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/id22afc2bd> , <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:58228> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/2666990> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/FFQKYPRQEYGKAF-UHFFFAOYSA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID101501054> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3423467> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27125628> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/d4b35> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/c3975> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=58228> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP275&oldid=140629>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/chebi/CHEBI:44337>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "N-acetyl-L-glutamate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/RFMMMVDNIPUKGG-YFKPBYRVSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:44337> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:44337" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/WP/Interaction/id5941ffc5> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:44337> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/1266066> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/RFMMMVDNIPUKGG-YFKPBYRVSA-L> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1549099> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27104528> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/bf516> , <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/a4dd6> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44337> .

<https://identifiers.org/sgd/S000004666>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ARG7" ;
        dc:identifier       <https://identifiers.org/sgd/S000004666> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000004666" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YMR062C> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/855084> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q04728> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/e52> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q04728> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000004666> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP275&oldid=140629>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/sgd/S000003624>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ARG3" ;
        dc:identifier       <https://identifiers.org/sgd/S000003624> ;
        dc:source           "SGD" ;
        dcterms:identifier  "S000003624" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP275_r140629> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/YJL088W> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/853357> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P05150> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP275_r140629/DataNode/e47> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P05150> ;
        foaf:page           <http://www.yeastgenome.org/locus/S000003624> .
