@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000157764>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "BRAF" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000157764> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000157764" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000157764> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/673> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/BRAF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P15056> , <https://identifiers.org/uniprot/H7C4S5> , <https://identifiers.org/uniprot/H7C560> , <https://identifiers.org/uniprot/A0A2R8Y679> , <https://identifiers.org/uniprot/A0A2R8Y467> , <https://identifiers.org/uniprot/A0A2R8Y8E0> , <https://identifiers.org/uniprot/H7C5K3> , <https://identifiers.org/uniprot/A0A2R8YDP5> , <https://identifiers.org/uniprot/A0A2R8Y492> , <https://identifiers.org/uniprot/A0A2U3TZI2> , <https://identifiers.org/uniprot/A0A2R8YES9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17853226> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/fef72> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A2R8Y467> , <http://purl.uniprot.org/uniprot/H7C4S5> , <http://purl.uniprot.org/uniprot/A0A2R8Y679> , <http://purl.uniprot.org/uniprot/H7C560> , <http://purl.uniprot.org/uniprot/A0A2R8YDP5> , <http://purl.uniprot.org/uniprot/P15056> , <http://purl.uniprot.org/uniprot/A0A2R8Y492> , <http://purl.uniprot.org/uniprot/H7C5K3> , <http://purl.uniprot.org/uniprot/A0A2U3TZI2> , <http://purl.uniprot.org/uniprot/A0A2R8YES9> , <http://purl.uniprot.org/uniprot/A0A2R8Y8E0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000157764> .

<https://identifiers.org/ensembl/ENSG00000196712>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NF1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000196712> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000196712" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000196712> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4763> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A1W2PPA7> , <https://identifiers.org/uniprot/A0A8Q3WL04> , <https://identifiers.org/uniprot/A0A8I5KSC3> , <https://identifiers.org/uniprot/P21359> , <https://identifiers.org/uniprot/A0A8Q3WL11> , <https://identifiers.org/uniprot/J3QLS2> , <https://identifiers.org/uniprot/A0A8I5KV71> , <https://identifiers.org/uniprot/J3QQN8> , <https://identifiers.org/uniprot/J3KSX8> , <https://identifiers.org/uniprot/A0A8I5KWT7> , <https://identifiers.org/uniprot/A0A8I5KSM3> , <https://identifiers.org/uniprot/K7EJE7> , <https://identifiers.org/uniprot/A0A8Q3WL49> , <https://identifiers.org/uniprot/A0A8I5KYK6> , <https://identifiers.org/uniprot/H0Y465> , <https://identifiers.org/uniprot/J3KSB5> , <https://identifiers.org/uniprot/J3QSG6> , <https://identifiers.org/uniprot/A0A1W2PS74> , <https://identifiers.org/uniprot/J3KRT8> , <https://identifiers.org/uniprot/A0A8I5KWR6> , <https://identifiers.org/uniprot/K7ENT2> , <https://identifiers.org/uniprot/K7EID4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20782771> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/f3f73> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KSC3> , <http://purl.uniprot.org/uniprot/P21359> , <http://purl.uniprot.org/uniprot/K7ENT2> , <http://purl.uniprot.org/uniprot/A0A8Q3WL04> , <http://purl.uniprot.org/uniprot/A0A8Q3WL11> , <http://purl.uniprot.org/uniprot/A0A8I5KV71> , <http://purl.uniprot.org/uniprot/A0A8I5KWT7> , <http://purl.uniprot.org/uniprot/J3QSG6> , <http://purl.uniprot.org/uniprot/K7EID4> , <http://purl.uniprot.org/uniprot/J3KRT8> , <http://purl.uniprot.org/uniprot/A0A8I5KWR6> , <http://purl.uniprot.org/uniprot/A0A8I5KSM3> , <http://purl.uniprot.org/uniprot/K7EJE7> , <http://purl.uniprot.org/uniprot/A0A1W2PPA7> , <http://purl.uniprot.org/uniprot/A0A8Q3WL49> , <http://purl.uniprot.org/uniprot/J3QQN8> , <http://purl.uniprot.org/uniprot/J3KSX8> , <http://purl.uniprot.org/uniprot/A0A1W2PS74> , <http://purl.uniprot.org/uniprot/H0Y465> , <http://purl.uniprot.org/uniprot/A0A8I5KYK6> , <http://purl.uniprot.org/uniprot/J3QLS2> , <http://purl.uniprot.org/uniprot/J3KSB5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000196712> .

<https://identifiers.org/ensembl/ENSG00000179295>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PTPN11" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000179295> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000179295" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/dc8f3> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000179295> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5781> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTPN11> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5QL30> , <https://identifiers.org/uniprot/A0A8I5KRZ3> , <https://identifiers.org/uniprot/A0A8I5KW48> , <https://identifiers.org/uniprot/H0YF12> , <https://identifiers.org/uniprot/A0A1W2PPU4> , <https://identifiers.org/uniprot/A0A8I5KVS6> , <https://identifiers.org/uniprot/A0A0U1RRI0> , <https://identifiers.org/uniprot/A0A8I5QJ58> , <https://identifiers.org/uniprot/Q06124> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905494> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/e9996> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KVS6> , <http://purl.uniprot.org/uniprot/A0A0U1RRI0> , <http://purl.uniprot.org/uniprot/A0A1W2PPU4> , <http://purl.uniprot.org/uniprot/A0A8I5KRZ3> , <http://purl.uniprot.org/uniprot/A0A8I5QL30> , <http://purl.uniprot.org/uniprot/Q06124> , <http://purl.uniprot.org/uniprot/A0A8I5KW48> , <http://purl.uniprot.org/uniprot/A0A8I5QJ58> , <http://purl.uniprot.org/uniprot/H0YF12> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000179295> .

<https://identifiers.org/wikipathways/WP422>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "MAPK cascade" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP422> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP422" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/WP/Interaction/id90ae3bc1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/c142a> ;
        foaf:page           <https://www.wikipathways.org/instance/WP422> .

<https://identifiers.org/ensembl/ENSG00000174775>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "HRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000174775> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000174775" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/a384d> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/cead2> , <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000174775> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3265> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01112> , <https://identifiers.org/uniprot/A0A804HJ06> , <https://identifiers.org/uniprot/X5D945> , <https://identifiers.org/uniprot/A0A804HKM6> , <https://identifiers.org/uniprot/A0A8C8MQR2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/deb89> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/b379f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/X5D945> , <http://purl.uniprot.org/uniprot/P01112> , <http://purl.uniprot.org/uniprot/A0A804HJ06> , <http://purl.uniprot.org/uniprot/A0A804HKM6> , <http://purl.uniprot.org/uniprot/A0A8C8MQR2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000174775> .

<https://identifiers.org/ensembl/ENSG00000213281>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000213281> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000213281" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/cead2> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/a384d> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000213281> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4893> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5U091> , <https://identifiers.org/uniprot/P01111> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030215> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/c96a8> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/f68bc> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01111> , <http://purl.uniprot.org/uniprot/Q5U091> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000213281> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/a384d>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Group/a384d> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000213281> , <https://identifiers.org/ensembl/ENSG00000133703> , <https://identifiers.org/ensembl/ENSG00000174775> , <https://identifiers.org/hmdb/HMDB0000960> .

<https://identifiers.org/ensembl/ENSG00000132155>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RAF1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000132155> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000132155" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000132155> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5894> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RAF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KSM4> , <https://identifiers.org/uniprot/A0A8I5KWS9> , <https://identifiers.org/uniprot/A0A8I5KQV4> , <https://identifiers.org/uniprot/A0A8I5KSB0> , <https://identifiers.org/uniprot/A0A8I5KTK4> , <https://identifiers.org/uniprot/A0A8I5KSV6> , <https://identifiers.org/uniprot/P04049> , <https://identifiers.org/uniprot/H7C155> , <https://identifiers.org/uniprot/A0A8I5KYC4> , <https://identifiers.org/uniprot/A0A8I5KR46> , <https://identifiers.org/uniprot/A0A8I5KWA9> , <https://identifiers.org/uniprot/A0A8I5QJG5> , <https://identifiers.org/uniprot/A0A8I5KS16> , <https://identifiers.org/uniprot/A0A8I5KSI1> , <https://identifiers.org/uniprot/A0A8I5KTA5> , <https://identifiers.org/uniprot/A0A0B4J1W9> , <https://identifiers.org/uniprot/A0A8I5QKZ6> , <https://identifiers.org/uniprot/A0A8I5KW44> , <https://identifiers.org/uniprot/A0A8I5KRD1> , <https://identifiers.org/uniprot/A0A8I5QKU8> , <https://identifiers.org/uniprot/L7RRS6> , <https://identifiers.org/uniprot/A0A8I5KQ33> , <https://identifiers.org/uniprot/A0A0S2Z559> , <https://identifiers.org/uniprot/A0A8I5KYP5> , <https://identifiers.org/uniprot/A0A8I5KWF7> , <https://identifiers.org/uniprot/A0A8I5KUW4> , <https://identifiers.org/uniprot/A0A8I5KT32> , <https://identifiers.org/uniprot/A0A8I5KX50> , <https://identifiers.org/uniprot/A0A0S2Z4L5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14903573> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/df578> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KTK4> , <http://purl.uniprot.org/uniprot/A0A8I5KQ33> , <http://purl.uniprot.org/uniprot/A0A8I5QKZ6> , <http://purl.uniprot.org/uniprot/A0A8I5KYP5> , <http://purl.uniprot.org/uniprot/H7C155> , <http://purl.uniprot.org/uniprot/A0A8I5KSI1> , <http://purl.uniprot.org/uniprot/A0A8I5KWA9> , <http://purl.uniprot.org/uniprot/A0A0S2Z559> , <http://purl.uniprot.org/uniprot/A0A8I5KSM4> , <http://purl.uniprot.org/uniprot/A0A8I5KSV6> , <http://purl.uniprot.org/uniprot/A0A8I5KWF7> , <http://purl.uniprot.org/uniprot/A0A8I5KUW4> , <http://purl.uniprot.org/uniprot/A0A8I5QJG5> , <http://purl.uniprot.org/uniprot/A0A0S2Z4L5> , <http://purl.uniprot.org/uniprot/A0A0B4J1W9> , <http://purl.uniprot.org/uniprot/L7RRS6> , <http://purl.uniprot.org/uniprot/A0A8I5KYC4> , <http://purl.uniprot.org/uniprot/A0A8I5KS16> , <http://purl.uniprot.org/uniprot/P04049> , <http://purl.uniprot.org/uniprot/A0A8I5KTA5> , <http://purl.uniprot.org/uniprot/A0A8I5KRD1> , <http://purl.uniprot.org/uniprot/A0A8I5KT32> , <http://purl.uniprot.org/uniprot/A0A8I5QKU8> , <http://purl.uniprot.org/uniprot/A0A8I5KWS9> , <http://purl.uniprot.org/uniprot/A0A8I5KSB0> , <http://purl.uniprot.org/uniprot/A0A8I5KR46> , <http://purl.uniprot.org/uniprot/A0A8I5KX50> , <http://purl.uniprot.org/uniprot/A0A8I5KW44> , <http://purl.uniprot.org/uniprot/A0A8I5KQV4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000132155> .

<https://identifiers.org/wikipathways/WP5471>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RTK" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP5471> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP5471" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/WP/Interaction/id90ae3bc1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/f8fc1> ;
        foaf:page           <https://www.wikipathways.org/instance/WP5471> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/ComplexBinding/dc8f3>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Group/dc8f3> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000179295> , <https://identifiers.org/ensembl/ENSG00000115904> , <https://identifiers.org/ensembl/ENSG00000177885> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/dc8f3> .

<https://identifiers.org/pmc/PMC12448840>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC12448840" ;
        cito:cites          <https://identifiers.org/wikipathways/WP2253> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC12448840> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/dc8f3>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Group/dc8f3> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000179295> , <https://identifiers.org/ensembl/ENSG00000115904> , <https://identifiers.org/ensembl/ENSG00000177885> .

<https://identifiers.org/wikipathways/WP2253>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP2253_r137724> .

<https://identifiers.org/chebi/CHEBI:15996>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "GTP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XKMLYUALXHKNFT-UUOKFMHZSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15996> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:15996" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/cead2> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15996> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/6569> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001273> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XKMLYUALXHKNFT-UUOKFMHZSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00044> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135398633> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6830> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q392227> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/d6b4f> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15996> .

<https://identifiers.org/pmc/PMC10913609>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC10913609" ;
        cito:cites          <https://identifiers.org/wikipathways/WP2253> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC10913609> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/ComplexBinding/a384d>
        rdf:type          wp:Interaction , wp:Binding , wp:ComplexBinding ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Group/a384d> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000133703> , <https://identifiers.org/hmdb/HMDB0000960> , <https://identifiers.org/ensembl/ENSG00000174775> , <https://identifiers.org/ensembl/ENSG00000213281> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/a384d> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP2253&oldid=137724>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/ensembl/ENSG00000115904>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SOS1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000115904> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000115904" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/dc8f3> , <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115904> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6654> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SOS1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q07889> , <https://identifiers.org/uniprot/A0A8I5KP47> , <https://identifiers.org/uniprot/G5E9C8> , <https://identifiers.org/uniprot/A0A8I5QJD1> , <https://identifiers.org/uniprot/A0A8I5KV97> , <https://identifiers.org/uniprot/A0A8I5QJ77> , <https://identifiers.org/uniprot/A0A8I5KY52> , <https://identifiers.org/uniprot/A0A8I5KWL0> , <https://identifiers.org/uniprot/C9K0N6> , <https://identifiers.org/uniprot/A0A8I5QJF3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14908123> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/d3463> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5QJF3> , <http://purl.uniprot.org/uniprot/C9K0N6> , <http://purl.uniprot.org/uniprot/A0A8I5QJ77> , <http://purl.uniprot.org/uniprot/Q07889> , <http://purl.uniprot.org/uniprot/A0A8I5KWL0> , <http://purl.uniprot.org/uniprot/G5E9C8> , <http://purl.uniprot.org/uniprot/A0A8I5KV97> , <http://purl.uniprot.org/uniprot/A0A8I5KP47> , <http://purl.uniprot.org/uniprot/A0A8I5KY52> , <http://purl.uniprot.org/uniprot/A0A8I5QJD1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000115904> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/cead2>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Group/cead2> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000213281> , <https://identifiers.org/ensembl/ENSG00000133703> , <https://identifiers.org/ensembl/ENSG00000174775> , <https://identifiers.org/chebi/CHEBI:15996> .

<https://identifiers.org/ec-code/2.7.12.2>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MEK" ;
        dc:identifier       <https://identifiers.org/ec-code/2.7.12.2> ;
        dc:source           "Enzyme Nomenclature" ;
        dcterms:identifier  "2.7.12.2" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/WP/Interaction/idedaaa89d> ;
        wp:bdbRhea          <https://identifiers.org/rhea/46608> , <https://identifiers.org/rhea/17989> , <https://identifiers.org/rhea/10596> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/e45b8> ;
        owl:sameAs          <http://rhea-db.org/rhea/10596> , <http://rhea-db.org/rhea/17989> , <http://rhea-db.org/rhea/46608> ;
        foaf:page           <http://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=2.7.12.2> .

<https://identifiers.org/pubmed/19363522>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "19363522" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/19363522> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/WP/Interaction/idedaaa89d>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Interaction/idedaaa89d> ;
        wp:participants   <https://identifiers.org/interpro/IPR008350> , <https://identifiers.org/ec-code/2.7.12.2> ;
        wp:source         <https://identifiers.org/ec-code/2.7.12.2> ;
        wp:target         <https://identifiers.org/interpro/IPR008350> .

<https://identifiers.org/hmdb/HMDB0000960>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "GDP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/CIKGWCTVFSRMJU-KVQBGUIXSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000960> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000960" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/a384d> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:28862> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388359> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000960> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/CIKGWCTVFSRMJU-KVQBGUIXSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00361> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439220> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27103932> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/a7b56> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000960> .

<https://identifiers.org/wikipathways/WP2253_r137724>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP2253> ;
        dc:source              "WikiPathways" ;
        dc:title               "Pilocytic astrocytoma"@en ;
        dcterms:description    "This pathway shows the relationship between BRAF signaling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation. \n\nBRAF is related in two alternative mechanisms in MAPK activation. The first is oncogenic fusion between SRGAP3 and RAF1, highlighted in yellow.  The second is a 3 basepair insertion in BRAF (KIAA1549), also highlighted in yellow. \n\nThis pathway is based on Figure 3 \"An overview of MAPK pathway alterations in PAs\" from [Jones et al](https://doi.org/10.1038/onc.2009.73)." ;
        dcterms:identifier     "WP2253" ;
        dcterms:references     <https://identifiers.org/pubmed/19363522> ;
        cito:cites             <https://identifiers.org/pubmed/19363522> ;
        wp:diseaseOntologyTag  obo:DOID_4851 , obo:DOID_3069 , obo:DOID_162 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP2253_r137724> ;
        wp:ontologyTag         wp:Curation:CPTAC , wp:Curation:AnalysisCollection , obo:DOID_3069 , wp:Curation:Diseases , obo:DOID_4851 , obo:PW_0000007 , obo:DOID_162 , obo:PW_0000711 ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000007 , obo:PW_0000711 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP2253&oldid=137724> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP2253&oldid=137724> ;
        foaf:page              <http://www.wikipathways.org/instance/WP2253_r137724> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP2253&oldid=137724>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/ComplexBinding/cead2>
        rdf:type          wp:ComplexBinding , wp:Interaction , wp:Binding ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Group/cead2> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000174775> , <https://identifiers.org/ensembl/ENSG00000133703> , <https://identifiers.org/ensembl/ENSG00000213281> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/cead2> , <https://identifiers.org/chebi/CHEBI:15996> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/interpro/IPR008350>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ERK" ;
        dc:identifier       <https://identifiers.org/interpro/IPR008350> ;
        dc:source           "InterPro" ;
        dcterms:identifier  "IPR008350" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP2253_r137724> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/WP/Interaction/idedaaa89d> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/c82b8> ;
        foaf:page           <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR008350> .

<http://rdf.wikipathways.org/Pathway/WP2253_r137724/WP/Interaction/id90ae3bc1>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Interaction/id90ae3bc1> ;
        wp:participants   <https://identifiers.org/wikipathways/WP5471> , <https://identifiers.org/wikipathways/WP422> ;
        wp:source         <https://identifiers.org/wikipathways/WP422> ;
        wp:target         <https://identifiers.org/wikipathways/WP5471> .

<https://identifiers.org/ensembl/ENSG00000133703>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000133703> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000133703" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/cead2> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/a384d> , <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000133703> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3845> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V4K2> , <https://identifiers.org/uniprot/G3V5T7> , <https://identifiers.org/uniprot/L7RSL8> , <https://identifiers.org/uniprot/A0A024RAV5> , <https://identifiers.org/uniprot/A0A8I5KUB5> , <https://identifiers.org/uniprot/A0A8I5KYH6> , <https://identifiers.org/uniprot/A0A8I5KQU3> , <https://identifiers.org/uniprot/A0A8I5KR86> , <https://identifiers.org/uniprot/A0A8I5KXN3> , <https://identifiers.org/uniprot/P01116> , <https://identifiers.org/uniprot/A0A8I5KQ21> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20969980> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/d2efa> , <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/cb337> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KUB5> , <http://purl.uniprot.org/uniprot/L7RSL8> , <http://purl.uniprot.org/uniprot/P01116> , <http://purl.uniprot.org/uniprot/A0A8I5KXN3> , <http://purl.uniprot.org/uniprot/G3V4K2> , <http://purl.uniprot.org/uniprot/A0A8I5KYH6> , <http://purl.uniprot.org/uniprot/A0A8I5KR86> , <http://purl.uniprot.org/uniprot/A0A024RAV5> , <http://purl.uniprot.org/uniprot/A0A8I5KQU3> , <http://purl.uniprot.org/uniprot/A0A8I5KQ21> , <http://purl.uniprot.org/uniprot/G3V5T7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000133703> .

<https://identifiers.org/ensembl/ENSG00000177885>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "GRB2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000177885> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000177885" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP2253_r137724/Complex/dc8f3> , <https://identifiers.org/wikipathways/WP2253_r137724> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000177885> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2885> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GRB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P62993> , <https://identifiers.org/uniprot/J3KT38> , <https://identifiers.org/uniprot/B0LPF3> , <https://identifiers.org/uniprot/J3QLF6> , <https://identifiers.org/uniprot/J3QRL5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905188> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP2253_r137724/DataNode/dc7bd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3QRL5> , <http://purl.uniprot.org/uniprot/B0LPF3> , <http://purl.uniprot.org/uniprot/P62993> , <http://purl.uniprot.org/uniprot/J3QLF6> , <http://purl.uniprot.org/uniprot/J3KT38> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000177885> .
