@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/pubmed/20541252>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "20541252" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/1717> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/20541252> .

<https://identifiers.org/chebi/CHEBI:8403>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Previtamin D3" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/YUGCAAVRZWBXEQ-WHTXLNIXSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:8403> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:8403" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id879db83f> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id44f7d0a6> , <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:8403> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4444516> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/YUGCAAVRZWBXEQ-WHTXLNIXSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C07711> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST03020222> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5281058> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q139299> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/b7c22> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST03020222> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8403> .

<https://identifiers.org/ncbigene/1593>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CYP27A1" ;
        dc:identifier       <https://identifiers.org/ncbigene/1593> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1593" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        dcterms:references  <https://identifiers.org/pubmed/7690968> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135929> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1593> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP27A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F8WD90> , <https://identifiers.org/uniprot/C9J1K5> , <https://identifiers.org/uniprot/Q02318> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/bfa93> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q02318> , <http://purl.uniprot.org/uniprot/C9J1K5> , <http://purl.uniprot.org/uniprot/F8WD90> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1593> .

<https://doi.org/10.1073%2FPNAS.0402490101>
        dc:source           "DOI" ;
        dcterms:identifier  "10.1073/PNAS.0402490101" .

<https://identifiers.org/pubmed/11111101>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "11111101" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/1717> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/11111101> .

<https://identifiers.org/pubmed/20418485>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "20418485" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/1717> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/20418485> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idaf407315>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/idaf407315> ;
        wp:participants   <https://identifiers.org/ncbigene/1717> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idc015bca4> ;
        wp:source         <https://identifiers.org/ncbigene/1717> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idc015bca4> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/ac27b>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/ac27b> ;
        wp:participants   <https://identifiers.org/ncbigene/2638> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3edf95c8> ;
        wp:source         <https://identifiers.org/ncbigene/2638> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3edf95c8> .

<https://identifiers.org/ncbigene/5741>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PTH" ;
        dc:identifier       <https://identifiers.org/ncbigene/5741> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5741" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id402e7170> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idba7e735a> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000152266> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5741> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PTH> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01270> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/b3aa4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01270> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5741> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1531&oldid=142319>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/hmdb/HMDB0001903>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Calcitriol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/GMRQFYUYWCNGIN-NKMMMXOESA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001903> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001903" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id646fbe27> , <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3a3d310> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3edf95c8> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17823> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4444108> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001903> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/GMRQFYUYWCNGIN-NKMMMXOESA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01673> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST03020258> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5280453> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q139195> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/ba01d> ;
        owl:sameAs          <https://swisslipids.org/rdf/SLM_000000475> , <https://www.lipidmaps.org/rdf/LMST03020258> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0001903> .

<https://identifiers.org/hmdb/HMDB0000067>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Cholesterol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/HVYWMOMLDIMFJA-DPAQBDIFSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000067> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000067" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idc015bca4> , <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16113> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5775> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000067> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/HVYWMOMLDIMFJA-DPAQBDIFSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00187> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST01010001> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5997> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q43656> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/de7a4> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST01010001> , <https://swisslipids.org/rdf/SLM_000000287> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000067> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id867ef92>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/id867ef92> ;
        wp:participants   <https://identifiers.org/ncbigene/1594> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3a3d310> ;
        wp:source         <https://identifiers.org/ncbigene/1594> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3a3d310> .

<https://identifiers.org/pubmed/18689389>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "18689389" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/18689389> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idba7e735a>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/idba7e735a> ;
        wp:participants   <https://identifiers.org/ncbigene/1594> , <https://identifiers.org/ncbigene/5741> ;
        wp:source         <https://identifiers.org/ncbigene/5741> ;
        wp:target         <https://identifiers.org/ncbigene/1594> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id6c5af5d8>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/id6c5af5d8> ;
        wp:participants   <https://identifiers.org/ncbigene/1591> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3306118f> ;
        wp:source         <https://identifiers.org/ncbigene/1591> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3306118f> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idc015bca4>
        rdf:type            wp:Conversion , wp:Interaction , wp:DirectedInteraction ;
        dc:source           "Rhea" ;
        dcterms:identifier  "23986" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbRhea          <https://identifiers.org/rhea/23986> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/idc015bca4> ;
        wp:participants     <https://identifiers.org/hmdb/HMDB0000067> , <https://identifiers.org/hmdb/HMDB0000032> ;
        wp:source           <https://identifiers.org/hmdb/HMDB0000032> ;
        wp:target           <https://identifiers.org/hmdb/HMDB0000067> ;
        owl:sameAs          <http://rhea-db.org/rhea/23986> .

<https://identifiers.org/hmdb/HMDB0003550>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Calcidiol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/JWUBBDSIWDLEOM-DTOXIADCSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0003550> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0003550" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3306118f> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3a3d310> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idb2536244> , <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/ide926490f> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17933> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4446820> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0003550> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/JWUBBDSIWDLEOM-DTOXIADCSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01561> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST03020246> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5283731> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q139307> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/a5036> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/a51a5> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST03020246> , <https://swisslipids.org/rdf/SLM_000000474> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0003550> .

<https://identifiers.org/ncbigene/1591>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CYP24A1" ;
        dc:identifier       <https://identifiers.org/ncbigene/1591> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1591" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id646fbe27> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id402e7170> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id6c5af5d8> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000019186> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1591> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP24A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q07973> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/e26ee> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q07973> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1591> .

<https://identifiers.org/hmdb/HMDB0001429>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Pi" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/NBIIXXVUZAFLBC-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001429> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001429" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:26078> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/979> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001429> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/NBIIXXVUZAFLBC-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00009> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1004> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q184782> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/bbd6c> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0001429> .

<https://identifiers.org/hmdb/HMDB0000032>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "7-Dehydro- cholesterol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/UCTLRSWJYQTBFZ-DDPQNLDTSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000032> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000032" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id879db83f> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idc015bca4> , <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17759> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388534> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000032> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/UCTLRSWJYQTBFZ-DDPQNLDTSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01164> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST01010069> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439423> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q139350> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/fd693> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST01010069> , <https://swisslipids.org/rdf/SLM_000000042> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000032> .

<https://identifiers.org/wikipathways/WP1531>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP1531_r142319> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/pmc/PMC4270790>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC4270790" ;
        cito:cites          <https://identifiers.org/wikipathways/WP1531> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC4270790> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idb2536244>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/idb2536244> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0003550> .

<https://identifiers.org/wikipathways/WP1531_r142319>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP1531> ;
        dc:source               "WikiPathways" ;
        dc:title                "Vitamin D metabolism"@en ;
        dcterms:description     "Photochemical synthesis of vitamin D3 (cholecalciferol, D3) occurs cutaneously where pro-vitamin D3 (7-dehydrocholesterol) is converted to pre-vitamin D3 (pre-D3) in response to ultraviolet B (sunlight) exposure. DHCR7 encodes the enzyme 7-dehydrocholesterol (7-DHC) reductase, which converts 7-DHC to cholesterol, thereby removing the substrate from the synthetic pathway of vitamin D3, a precursor of 25-hydroxyvitamin D3.The finding that common variants at DHCR7 are strongly associated with circulating 25-hydroxyvitamin D concentrations suggests that this enzyme could have a larger role in regulation of vitamin D status than has previously been recognised. Vitamin D3, obtained from the isomerization of pre-vitamin D3 in the epidermal basal layers or intestinal absorption of natural and fortified foods and supplements, binds to vitamin D-binding protein (DBP) in the bloodstream, and is transported to the liver. D3 is hydroxylated by liver 25-hydroxylases (25-OHase). The resultant 25-hydroxycholecalciferol (25(OH)D3) is 1-hydroxylated in the kidney by 25-hydroxyvitamin D3-1 -hydroxylase (1-OHase). This yields the active secosteroid 1 ,25(OH)2D3 (calcitriol), which has different effects on various target tissues. The synthesis of 1,25(OH)2D3 from 25(OH)D3 is stimulated by parathyroid hormone (PTH) and suppressed by Ca2+, Pi and 1,25(OH)2D3 itself. The rate-limiting step in catabolism is the degradation of 25(OH)D3 and 1,25(OH)2D3 to 24,25(OH)D3 and 1,24,25(OH)2D3, respectively,which occurs through 24-hydroxylation by 25-hydroxyvitamin D 24-hydroxylase (24-OHase), encoded by the CYP24A1 gene. 24,25(OH)D3 and 1,24,25(OH)2D3 are consequently excreted. Vitamin D activity is mediated through binding of 1,25(OH)2D3 to the vitamin D receptor (VDR), which can regulate transcription of other genes involved in cell regulation, growth, and immunity. VDR modulates the expression of genes by forming a heterodimer complex with retinoid-X-receptors (RXR).\n\nProteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP1531)." ;
        dcterms:identifier      "WP1531" ;
        dcterms:references      <https://identifiers.org/pubmed/18689389> ;
        cito:cites              <https://identifiers.org/pubmed/11111101> , <https://identifiers.org/pubmed/18689389> , <https://identifiers.org/pubmed/7690968> , <https://identifiers.org/pubmed/15128933> , <https://identifiers.org/pubmed/20541252> , <https://identifiers.org/pubmed/20418485> ;
        wp:cellTypeOntologyTag  obo:CL_0002620 , obo:CL_0000182 , obo:CL_1000497 ;
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        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0001011 , obo:PW_0000135 ;
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        foaf:page               <http://www.wikipathways.org/instance/WP1531_r142319> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id879db83f>
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        wp:participants   <https://identifiers.org/chebi/CHEBI:8403> , <https://identifiers.org/hmdb/HMDB0000032> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0000032> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:8403> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id402e7170>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
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        wp:source         <https://identifiers.org/ncbigene/5741> ;
        wp:target         <https://identifiers.org/ncbigene/1591> .

<https://identifiers.org/hmdb/HMDB0000464>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ca" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000464> ;
        dc:source           "HMDB" ;
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        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID271> ;
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        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000464> .

<https://identifiers.org/ncbigene/120227>
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        rdfs:label          "CYP2R1" ;
        dc:identifier       <https://identifiers.org/ncbigene/120227> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "120227" ;
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        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP2R1> ;
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        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PS56> , <http://purl.uniprot.org/uniprot/E9PJT9> , <http://purl.uniprot.org/uniprot/K7EMQ4> , <http://purl.uniprot.org/uniprot/Q6VVX0> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/120227> .

<https://identifiers.org/wikidata/Q2440935>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Alpha globulin" ;
        dc:identifier       <https://identifiers.org/wikidata/Q2440935> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q2440935" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idd3589337> , <https://identifiers.org/wikipathways/WP1531_r142319> ;
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        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/d140a> ;
        foaf:page           <https://scholia.toolforge.org/Q2440935> .

<https://identifiers.org/hmdb/HMDB0000876>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Cholecalciferol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/QYSXJUFSXHHAJI-YRZJJWOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000876> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000876" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id44f7d0a6> , <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/ide926490f> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:28940> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4444353> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000876> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/QYSXJUFSXHHAJI-YRZJJWOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C05443> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST03020001> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5280795> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q139347> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/dc335> ;
        owl:sameAs          <https://swisslipids.org/rdf/SLM_000000473> , <https://www.lipidmaps.org/rdf/LMST03020001> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000876> .

<https://identifiers.org/hmdb/HMDB0000430>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Inactive 24,25-OH- vitamin D" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FCKJYANJHNLEEP-OIMXRAFZSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000430> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000430" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3306118f> , <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:89324> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/17215953> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000430> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/FCKJYANJHNLEEP-OIMXRAFZSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID12895043> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27161510> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/a3330> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000430> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1531&oldid=142319>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/ide926490f>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/becb8> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/ide926490f> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0003550> , <https://identifiers.org/hmdb/HMDB0000876> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0000876> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0003550> .

<https://identifiers.org/ncbigene/6257>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RXRB" ;
        dc:identifier       <https://identifiers.org/ncbigene/6257> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6257" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000204231> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6257> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RXRB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0S2Z570> , <https://identifiers.org/uniprot/E9PK75> , <https://identifiers.org/uniprot/P28702> , <https://identifiers.org/uniprot/Q5STP9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/d14a3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28702> , <http://purl.uniprot.org/uniprot/A0A0S2Z570> , <http://purl.uniprot.org/uniprot/Q5STP9> , <http://purl.uniprot.org/uniprot/E9PK75> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6257> .

<https://identifiers.org/pubmed/7690968>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "7690968" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/1593> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/7690968> .

<https://identifiers.org/pmc/PMC12532006>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC12532006" ;
        cito:cites          <https://identifiers.org/wikipathways/WP1531> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC12532006> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3a3d310>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
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        wp:participants   <https://identifiers.org/hmdb/HMDB0001903> , <https://identifiers.org/hmdb/HMDB0003550> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0003550> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0001903> .

<https://identifiers.org/ncbigene/2638>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Vitamin D  binding protein" ;
        dc:identifier       <https://identifiers.org/ncbigene/2638> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2638" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/ac27b> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000145321> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2638> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GC> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D6RF20> , <https://identifiers.org/uniprot/D6RF35> , <https://identifiers.org/uniprot/D6RBJ7> , <https://identifiers.org/uniprot/P02774> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/c72dd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D6RF35> , <http://purl.uniprot.org/uniprot/D6RBJ7> , <http://purl.uniprot.org/uniprot/D6RF20> , <http://purl.uniprot.org/uniprot/P02774> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2638> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id44f7d0a6>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/b6cd3> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/id44f7d0a6> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0000876> , <https://identifiers.org/chebi/CHEBI:8403> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:8403> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0000876> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3edf95c8>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
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        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/id3edf95c8> ;
        wp:participants   <https://identifiers.org/ncbigene/7421> , <https://identifiers.org/hmdb/HMDB0001903> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0001903> ;
        wp:target         <https://identifiers.org/ncbigene/7421> .

<https://identifiers.org/ncbigene/1594>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CYP27B1" ;
        dc:identifier       <https://identifiers.org/ncbigene/1594> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1594" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idba7e735a> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id867ef92> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000111012> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1594> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP27B1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F8VWR7> , <https://identifiers.org/uniprot/O15528> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/e42dc> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O15528> , <http://purl.uniprot.org/uniprot/F8VWR7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1594> .

<https://identifiers.org/uniprot/P02774>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "Vitamin D binding protein" ;
        dc:identifier       <https://identifiers.org/uniprot/P02774> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P02774" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000145321> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2638> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/GC> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D6RF35> , <https://identifiers.org/uniprot/D6RBJ7> , <https://identifiers.org/uniprot/D6RF20> , <https://identifiers.org/uniprot/P02774> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/f687e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D6RF20> , <http://purl.uniprot.org/uniprot/D6RBJ7> , <http://purl.uniprot.org/uniprot/D6RF35> , <http://purl.uniprot.org/uniprot/P02774> ;
        foaf:page           <http://www.uniprot.org/uniprot/P02774> .

<https://identifiers.org/ncbigene/6256>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RXRA" ;
        dc:identifier       <https://identifiers.org/ncbigene/6256> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6256" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000186350> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6256> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RXRA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A3B3IS44> , <https://identifiers.org/uniprot/F1D8Q5> , <https://identifiers.org/uniprot/A0A5F9ZHH6> , <https://identifiers.org/uniprot/P19793> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/a4a3c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F1D8Q5> , <http://purl.uniprot.org/uniprot/P19793> , <http://purl.uniprot.org/uniprot/A0A3B3IS44> , <http://purl.uniprot.org/uniprot/A0A5F9ZHH6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6256> .

<https://identifiers.org/ncbigene/1717>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "DHCR7" ;
        dc:identifier       <https://identifiers.org/ncbigene/1717> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1717" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idaf407315> ;
        dcterms:references  <https://identifiers.org/pubmed/20418485> , <https://identifiers.org/pubmed/11111101> , <https://identifiers.org/pubmed/20541252> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000172893> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1717> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DHCR7> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A804HJQ7> , <https://identifiers.org/uniprot/H0YE57> , <https://identifiers.org/uniprot/B4E1K5> , <https://identifiers.org/uniprot/A0A804HL56> , <https://identifiers.org/uniprot/E9PJ54> , <https://identifiers.org/uniprot/H0YEJ5> , <https://identifiers.org/uniprot/E9PM00> , <https://identifiers.org/uniprot/Q9UBM7> , <https://identifiers.org/uniprot/E9PQ71> , <https://identifiers.org/uniprot/H0YCS7> , <https://identifiers.org/uniprot/A0A804HI25> , <https://identifiers.org/uniprot/A0A8I5KRR9> , <https://identifiers.org/uniprot/E9PIP9> , <https://identifiers.org/uniprot/E9PRL8> , <https://identifiers.org/uniprot/A0A804HJI8> , <https://identifiers.org/uniprot/E9PLZ2> , <https://identifiers.org/uniprot/A0A024R5F7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/bcdc9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PLZ2> , <http://purl.uniprot.org/uniprot/A0A8I5KRR9> , <http://purl.uniprot.org/uniprot/A0A804HL56> , <http://purl.uniprot.org/uniprot/H0YE57> , <http://purl.uniprot.org/uniprot/A0A024R5F7> , <http://purl.uniprot.org/uniprot/E9PQ71> , <http://purl.uniprot.org/uniprot/E9PRL8> , <http://purl.uniprot.org/uniprot/A0A804HJQ7> , <http://purl.uniprot.org/uniprot/B4E1K5> , <http://purl.uniprot.org/uniprot/A0A804HJI8> , <http://purl.uniprot.org/uniprot/H0YEJ5> , <http://purl.uniprot.org/uniprot/Q9UBM7> , <http://purl.uniprot.org/uniprot/A0A804HI25> , <http://purl.uniprot.org/uniprot/E9PM00> , <http://purl.uniprot.org/uniprot/H0YCS7> , <http://purl.uniprot.org/uniprot/E9PJ54> , <http://purl.uniprot.org/uniprot/E9PIP9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1717> .

<https://identifiers.org/ncbigene/7421>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "VDR" ;
        dc:identifier       <https://identifiers.org/ncbigene/7421> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7421" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1531_r142319> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3edf95c8> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000111424> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7421> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/VDR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F8VVY8> , <https://identifiers.org/uniprot/F8VRJ4> , <https://identifiers.org/uniprot/F1D8P8> , <https://identifiers.org/uniprot/F8VXQ9> , <https://identifiers.org/uniprot/P11473> , <https://identifiers.org/uniprot/F8VPF8> , <https://identifiers.org/uniprot/A0A5K1VW50> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1531_r142319/DataNode/d69a4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P11473> , <http://purl.uniprot.org/uniprot/F8VPF8> , <http://purl.uniprot.org/uniprot/A0A5K1VW50> , <http://purl.uniprot.org/uniprot/F8VVY8> , <http://purl.uniprot.org/uniprot/F8VXQ9> , <http://purl.uniprot.org/uniprot/F8VRJ4> , <http://purl.uniprot.org/uniprot/F1D8P8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7421> .

<https://identifiers.org/pmc/PMC10775474>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC10775474" ;
        cito:cites          <https://identifiers.org/wikipathways/WP1531> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC10775474> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idd3589337>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/idd3589337> ;
        wp:participants   <https://identifiers.org/wikidata/Q2440935> , <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idb2536244> ;
        wp:source         <https://identifiers.org/wikidata/Q2440935> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/idb2536244> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id646fbe27>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/id646fbe27> ;
        wp:participants   <https://identifiers.org/ncbigene/1591> , <https://identifiers.org/hmdb/HMDB0001903> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0001903> ;
        wp:target         <https://identifiers.org/ncbigene/1591> .

<https://identifiers.org/pubmed/15128933>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "15128933" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/120227> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q24562083> ;
        owl:sameAs          <https://doi.org/10.1073%2FPNAS.0402490101> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/15128933> .

<http://rdf.wikipathways.org/Pathway/WP1531_r142319/WP/Interaction/id3306118f>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1531_r142319> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1531_r142319/Interaction/id3306118f> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0000430> , <https://identifiers.org/hmdb/HMDB0003550> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0003550> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0000430> .
