@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ncbigene/1636>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "ACE" ;
        dc:identifier       <https://identifiers.org/ncbigene/1636> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1636" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id3739bd1> , <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000159640> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1636> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACE> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3QLR4> , <https://identifiers.org/uniprot/J3QSC7> , <https://identifiers.org/uniprot/J3KS28> , <https://identifiers.org/uniprot/J3KRH5> , <https://identifiers.org/uniprot/P12821> , <https://identifiers.org/uniprot/J3KTB8> , <https://identifiers.org/uniprot/J3KTH9> , <https://identifiers.org/uniprot/J3KSQ5> , <https://identifiers.org/uniprot/A0A0A0MSN4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/e5d6d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0A0MSN4> , <http://purl.uniprot.org/uniprot/J3KTB8> , <http://purl.uniprot.org/uniprot/P12821> , <http://purl.uniprot.org/uniprot/J3KRH5> , <http://purl.uniprot.org/uniprot/J3KSQ5> , <http://purl.uniprot.org/uniprot/J3KTH9> , <http://purl.uniprot.org/uniprot/J3QSC7> , <http://purl.uniprot.org/uniprot/J3KS28> , <http://purl.uniprot.org/uniprot/J3QLR4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1636> .

<https://doi.org/10.1007%2FS00134-020-05985-9>
        dc:source           "DOI" ;
        dcterms:identifier  "10.1007/S00134-020-05985-9" .

<https://doi.org/10.1186%2Fs40001-024-01951-z>
        rdf:type            wp:PublicationReference ;
        dc:source           "DOI" ;
        dcterms:identifier  "10.1186/s40001-024-01951-z" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4883> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id695320d0>
        rdf:type            wp:DirectedInteraction , wp:Interaction , wp:Conversion ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32125455> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id695320d0> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:2718> , <https://identifiers.org/ncbigene/183> ;
        wp:source           <https://identifiers.org/ncbigene/183> ;
        wp:target           <https://identifiers.org/chebi/CHEBI:2718> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id965b8019>
        rdf:type            wp:DirectedInteraction , wp:Interaction , wp:Binding ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32125455> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id965b8019> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:55438> , <https://identifiers.org/ncbigene/4142> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:55438> ;
        wp:target           <https://identifiers.org/ncbigene/4142> .

<https://identifiers.org/chebi/CHEBI:35222>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "TMPRSS2 inhibitor" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:35222> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:35222" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:35222> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q163767> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/a45e2> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35222> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id3739bd1>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id3739bd1> ;
        wp:participants   <https://identifiers.org/ncbigene/1636> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id45cf6f5e> ;
        wp:source         <https://identifiers.org/ncbigene/1636> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id45cf6f5e> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id45cf6f5e>
        rdf:type            wp:Conversion , wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32125455> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id45cf6f5e> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:2718> , <https://identifiers.org/chebi/CHEBI:2719> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:2718> ;
        wp:target           <https://identifiers.org/chebi/CHEBI:2719> .

<https://doi.org/10.1016%2FJ.CELL.2020.02.052>
        dc:source           "DOI" ;
        dcterms:identifier  "10.1016/J.CELL.2020.02.052" .

<https://identifiers.org/ncbigene/4142>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAS1" ;
        dc:identifier       <https://identifiers.org/ncbigene/4142> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "4142" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id501a4bdc> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id965b8019> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130368> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4142> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAS1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/W8W3P4> , <https://identifiers.org/uniprot/P04201> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/c93ee> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/W8W3P4> , <http://purl.uniprot.org/uniprot/P04201> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/4142> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4883&oldid=137250>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/chebi/CHEBI:80128>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin 1-9" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/LJXGOQOPNPFXFT-JWRYNVNRSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:80128> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:80128" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id501a4bdc> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:147351> , <https://identifiers.org/chebi/CHEBI:80128> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/LJXGOQOPNPFXFT-JWRYNVNRSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C15851> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID146026568> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID71745056> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q58310864> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/a0555> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:80128> .

<https://identifiers.org/pubmed/32142651>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "32142651" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/idc649fb6a> , <https://identifiers.org/ensembl/ENSG00000184012> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q88292103> ;
        owl:sameAs          <https://doi.org/10.1016%2FJ.CELL.2020.02.052> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/32142651> .

<https://identifiers.org/wikipathways/WP4883_r137250>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP4883> ;
        dc:source              "WikiPathways" ;
        dc:title               "SARS-CoV-2 and ACE2 receptor: molecular mechanisms"@en ;
        dcterms:description    "For initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, the large viral Spike (S) protein needs to be primed by host proteases. For SARS-CoV-2 that is the serine protease TMPRSS2. After binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2), the virus undergoes endocytosis. After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin 2 accumulation. Local activation of the angiotensin pathway system may mediate lung injury responses to viral insults. \nACE denotes angiotensin-converting enzyme and ARB angiotensin-receptor blocker.\n" ;
        dcterms:identifier     "WP4883" ;
        dcterms:references     <https://doi.org/10.1056/NEJMsr2005760> , <https://identifiers.org/pubmed/32125455> ;
        cito:cites             <https://identifiers.org/pubmed/32125455> , <https://identifiers.org/pubmed/32142651> , <https://doi.org/10.1056/NEJMsr2005760> ;
        wp:diseaseOntologyTag  obo:DOID_0080600 , obo:DOID_934 , obo:DOID_2945 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP4883_r137250> ;
        wp:ontologyTag         obo:DOID_2945 , wp:Curation:AnalysisCollection , obo:DOID_0080600 , obo:DOID_934 , obo:PW_0000245 , wp:Curation:COVID19 ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000245 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4883&oldid=137250> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4883&oldid=137250> ;
        foaf:page              <http://www.wikipathways.org/instance/WP4883_r137250> .

<https://identifiers.org/chebi/CHEBI:90710>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "ARBs surface  receptor blocker" , "ACE2 surface  receptor blocker" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:90710> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:90710" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:90710> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q25098750> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/d2e3a> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/cf757> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:90710> .

<https://identifiers.org/ncbigene/185>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "AT1R" ;
        dc:identifier       <https://identifiers.org/ncbigene/185> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "185" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id7114ee4c> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000144891> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/185> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AGTR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P30556> , <https://identifiers.org/uniprot/D3DNG8> , <https://identifiers.org/uniprot/A0A0A0MSE3> , <https://identifiers.org/uniprot/Q53YY0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/f6bb2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P30556> , <http://purl.uniprot.org/uniprot/D3DNG8> , <http://purl.uniprot.org/uniprot/Q53YY0> , <http://purl.uniprot.org/uniprot/A0A0A0MSE3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/185> .

<https://identifiers.org/ncbigene/5972>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "REN" ;
        dc:identifier       <https://identifiers.org/ncbigene/5972> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5972" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id4093d262> , <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000143839> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5972> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/REN> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P00797> , <https://identifiers.org/uniprot/A0A1B0GUZ2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/c91b1> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P00797> , <http://purl.uniprot.org/uniprot/A0A1B0GUZ2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5972> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4883&oldid=137250>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id7114ee4c>
        rdf:type            wp:Binding , wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32125455> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id7114ee4c> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:2719> , <https://identifiers.org/ncbigene/185> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:2719> ;
        wp:target           <https://identifiers.org/ncbigene/185> .

<https://identifiers.org/chebi/CHEBI:2719>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin 2" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/CZGUSIXMZVURDU-JZXHSEFVSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:2719> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "2719" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id45cf6f5e> , <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id7114ee4c> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:2719> , <https://identifiers.org/chebi/CHEBI:58506> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/150504> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/CZGUSIXMZVURDU-JZXHSEFVSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C02135> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID45266664> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID172198> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q412999> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/d23b7> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=2719> .

<https://identifiers.org/wikipathways/WP4883>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4883_r137250> .

<https://identifiers.org/pubmed/32125455>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "32125455" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/idc649fb6a> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id45cf6f5e> , <https://identifiers.org/ensembl/ENSG00000184012> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id7114ee4c> , <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id501a4bdc> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id695320d0> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id965b8019> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q88291889> ;
        owl:sameAs          <https://doi.org/10.1007%2FS00134-020-05985-9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/32125455> .

<https://doi.org/10.1056/NEJMsr2005760>
        rdf:type          wp:PublicationReference ;
        dc:source         "DOI" ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4883_r137250> ;
        foaf:page         <https://doi.org/10.1056/NEJMsr2005760> .

<https://identifiers.org/ncbigene/59272>
        rdf:type            wp:Protein , wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Soluble ACE2" , "ACE2" ;
        dc:identifier       <https://identifiers.org/ncbigene/59272> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "59272" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/idc649fb6a> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130234> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/59272> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACE2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V4H0> , <https://identifiers.org/uniprot/A0A7I2V3X6> , <https://identifiers.org/uniprot/Q9BYF1> , <https://identifiers.org/uniprot/A0A7I2V5W5> , <https://identifiers.org/uniprot/A0A7I2V2E9> , <https://identifiers.org/uniprot/A0A7I2V3N4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/bf1a9> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/b2ec5> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/dac5e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9BYF1> , <http://purl.uniprot.org/uniprot/A0A7I2V4H0> , <http://purl.uniprot.org/uniprot/A0A7I2V3N4> , <http://purl.uniprot.org/uniprot/A0A7I2V2E9> , <http://purl.uniprot.org/uniprot/A0A7I2V5W5> , <http://purl.uniprot.org/uniprot/A0A7I2V3X6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/59272> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id4093d262>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id4093d262> ;
        wp:participants   <https://identifiers.org/ncbigene/5972> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id695320d0> ;
        wp:source         <https://identifiers.org/ncbigene/5972> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id695320d0> .

<https://identifiers.org/chebi/CHEBI:2718>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin 1" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ORWYRWWVDCYOMK-HBZPZAIKSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:2718> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "2718" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id45cf6f5e> , <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id695320d0> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:2718> , <https://identifiers.org/chebi/CHEBI:147350> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/23150106> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0061196> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ORWYRWWVDCYOMK-HBZPZAIKSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00873> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3081372> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID90657349> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q539799> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/d391a> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=2718> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/ensembl/ENSG00000184012>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TMPRSS2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000184012> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000184012" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32142651> , <https://identifiers.org/pubmed/32125455> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000184012> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/124905021> , <https://identifiers.org/ncbigene/7113> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TMPRSS2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V474> , <https://identifiers.org/uniprot/A0A7I2V509> , <https://identifiers.org/uniprot/A0A7I2V650> , <https://identifiers.org/uniprot/A0A7I2YQ98> , <https://identifiers.org/uniprot/A0A7I2V3D1> , <https://identifiers.org/uniprot/C9JKZ3> , <https://identifiers.org/uniprot/C9J5Y1> , <https://identifiers.org/uniprot/A0A7I2V5F9> , <https://identifiers.org/uniprot/O15393> , <https://identifiers.org/uniprot/A0A7I2V5N2> , <https://identifiers.org/uniprot/C9JB05> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18032025> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/b141b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2V5N2> , <http://purl.uniprot.org/uniprot/A0A7I2V3D1> , <http://purl.uniprot.org/uniprot/A0A7I2V5F9> , <http://purl.uniprot.org/uniprot/A0A7I2YQ98> , <http://purl.uniprot.org/uniprot/C9JB05> , <http://purl.uniprot.org/uniprot/A0A7I2V650> , <http://purl.uniprot.org/uniprot/C9J5Y1> , <http://purl.uniprot.org/uniprot/A0A7I2V474> , <http://purl.uniprot.org/uniprot/A0A7I2V509> , <http://purl.uniprot.org/uniprot/C9JKZ3> , <http://purl.uniprot.org/uniprot/O15393> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000184012> .

<https://identifiers.org/ncbigene/183>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AGT" ;
        dc:identifier       <https://identifiers.org/ncbigene/183> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "183" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id695320d0> , <https://identifiers.org/wikipathways/WP4883_r137250> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135744> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/183> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AGT> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7P0TA52> , <https://identifiers.org/uniprot/P01019> , <https://identifiers.org/uniprot/A0A7P0T9S6> , <https://identifiers.org/uniprot/A0A7P0T8D1> , <https://identifiers.org/uniprot/A0A7P0TAP4> , <https://identifiers.org/uniprot/A0A7P0Z441> , <https://identifiers.org/uniprot/A0A7P0TBH1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/f53bd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0TBH1> , <http://purl.uniprot.org/uniprot/A0A7P0T8D1> , <http://purl.uniprot.org/uniprot/P01019> , <http://purl.uniprot.org/uniprot/A0A7P0TAP4> , <http://purl.uniprot.org/uniprot/A0A7P0TA52> , <http://purl.uniprot.org/uniprot/A0A7P0Z441> , <http://purl.uniprot.org/uniprot/A0A7P0T9S6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/183> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id501a4bdc>
        rdf:type            wp:Interaction , wp:Binding , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32125455> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/id501a4bdc> ;
        wp:participants     <https://identifiers.org/ncbigene/4142> , <https://identifiers.org/chebi/CHEBI:80128> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:80128> ;
        wp:target           <https://identifiers.org/ncbigene/4142> .

<http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/idc649fb6a>
        rdf:type            wp:DirectedInteraction , wp:Interaction , wp:TranscriptionTranslation ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> ;
        dcterms:references  <https://identifiers.org/pubmed/32125455> , <https://identifiers.org/pubmed/32142651> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/Interaction/idc649fb6a> ;
        wp:participants     <https://identifiers.org/ncbigene/59272> ;
        wp:source           <https://identifiers.org/ncbigene/59272> ;
        wp:target           <https://identifiers.org/ncbigene/59272> .

<https://identifiers.org/chebi/CHEBI:55438>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin 1-7" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/PVHLMTREZMEJCG-GDTLVBQBSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:55438> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:55438" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4883_r137250> , <http://rdf.wikipathways.org/Pathway/WP4883_r137250/WP/Interaction/id965b8019> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:58922> , <https://identifiers.org/chebi/CHEBI:55438> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/110354> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/PVHLMTREZMEJCG-GDTLVBQBSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C15850> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID46878481> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID123805> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18480216> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4883_r137250/DataNode/cfdf4> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:55438> .
