@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/chebi/CHEBI:18035>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "DAG" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:18035> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:18035" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idbab35e73> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idb05e238a> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00165> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMGL0201> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q161466> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/f5707> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMGL0201> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18035> .

<https://identifiers.org/pubmed/30886364>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "30886364" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/30886364> .

<https://identifiers.org/ncbigene/1081>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TSH" ;
        dc:identifier       <https://identifiers.org/ncbigene/1081> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "1081" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/dca29> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/f9073> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135346> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1081> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CGA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A087WYZ4> , <https://identifiers.org/uniprot/A0A0D9SGA7> , <https://identifiers.org/uniprot/Q6I9S8> , <https://identifiers.org/uniprot/P01215> , <https://identifiers.org/uniprot/A0A0D9SFJ6> , <https://identifiers.org/uniprot/A0A0R4J2F0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/abd53> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087WYZ4> , <http://purl.uniprot.org/uniprot/A0A0D9SGA7> , <http://purl.uniprot.org/uniprot/Q6I9S8> , <http://purl.uniprot.org/uniprot/A0A0R4J2F0> , <http://purl.uniprot.org/uniprot/P01215> , <http://purl.uniprot.org/uniprot/A0A0D9SFJ6> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/1081> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id17eabccc>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id17eabccc> ;
        wp:participants   <https://identifiers.org/ncbigene/7173> , <https://identifiers.org/chebi/CHEBI:16240> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:16240> ;
        wp:target         <https://identifiers.org/ncbigene/7173> .

<https://identifiers.org/wikipathways/WP1981>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP1981_r139940> .

<https://identifiers.org/ncbigene/7200>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TRH" ;
        dc:identifier       <https://identifiers.org/ncbigene/7200> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7200" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/dca29> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000170893> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7200> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TRH> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P20396> , <https://identifiers.org/uniprot/D6RFM1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/adcdb> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P20396> , <http://purl.uniprot.org/uniprot/D6RFM1> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7200> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/f9073>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/f9073> ;
        wp:participants   <https://identifiers.org/ncbigene/7253> , <https://identifiers.org/ncbigene/1081> ;
        wp:source         <https://identifiers.org/ncbigene/1081> ;
        wp:target         <https://identifiers.org/ncbigene/7253> .

<https://identifiers.org/ensembl/ENSG00000131620>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ANO1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000131620> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000131620" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000131620> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/55107> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ANO1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5XXA6> , <https://identifiers.org/uniprot/E9PP68> , <https://identifiers.org/uniprot/E9PS90> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18041552> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/c0401> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PS90> , <http://purl.uniprot.org/uniprot/E9PP68> , <http://purl.uniprot.org/uniprot/Q5XXA6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000131620> .

<https://identifiers.org/hmdb/HMDB0001532>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "ATP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/SUYVUBYJARFZHO-RRKCRQDMSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001532> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001532" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id3e42b5d9> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16284> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/15194> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001532> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/SUYVUBYJARFZHO-RRKCRQDMSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00131> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID15993> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q201090> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/d27b7> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0001532> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id45568e9d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id45568e9d> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:29108> , <https://identifiers.org/chebi/CHEBI:138527> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:138527> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:29108> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idb05e238a>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/idb05e238a> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:18035> , <https://identifiers.org/chebi/CHEBI:83416> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:83416> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:18035> .

<https://identifiers.org/chemspider/5707>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Triiodothyronine (T3)" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/AUYYCJSJGJYCDS-LBPRGKRZSA-N> ;
        dc:identifier       <https://identifiers.org/chemspider/5707> ;
        dc:source           "Chemspider" ;
        dcterms:identifier  "5707" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:533015> , <https://identifiers.org/chebi/CHEBI:18258> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5707> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000265> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/AUYYCJSJGJYCDS-LBPRGKRZSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7048703> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5920> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q327362> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/fcff2> ;
        foaf:page           <https://www.chemspider.com/5707> .

<https://identifiers.org/hmdb/HMDB0012238>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "127 Iodide" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XMBWDFGMSWQBCA-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0012238> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0012238" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16382> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/28015> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0012238> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XMBWDFGMSWQBCA-UHFFFAOYSA-M> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00708> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID30165> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q407654> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/f3eaa> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/f82ce> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/bed55> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0012238> .

<https://identifiers.org/chebi/CHEBI:138527>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Ins(1,4,5)P3" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/PVEVFIAVCISJSO-FOJCDXFYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:138527> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:138527" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/iddb5ca020> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id45568e9d> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:138527> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/PVEVFIAVCISJSO-FOJCDXFYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID10486214> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q106030447> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/a6a71> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:138527> .

<https://identifiers.org/pubmed/7871153>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "7871153" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/7871153> .

<https://identifiers.org/chebi/CHEBI:83416>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "PtdIns(4,5)P2" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ANFYVAHJWGJYAT-QLCNXWICSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:83416> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:83416" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/iddb5ca020> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idb05e238a> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:83416> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ANFYVAHJWGJYAT-QLCNXWICSA-G> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27156808> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/df9e0> ;
        owl:sameAs          <https://swisslipids.org/rdf/SLM_000443628> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:83416> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/ida5f6ca67>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/ida5f6ca67> ;
        wp:participants   <https://identifiers.org/ncbigene/2002> , <https://identifiers.org/ncbigene/5595> ;
        wp:source         <https://identifiers.org/ncbigene/5595> ;
        wp:target         <https://identifiers.org/ncbigene/2002> .

<https://identifiers.org/ncbigene/5595>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ERK1" ;
        dc:identifier       <https://identifiers.org/ncbigene/5595> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5595" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/ida5f6ca67> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102882> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PQW4> , <https://identifiers.org/uniprot/H0YDH9> , <https://identifiers.org/uniprot/H0YEX6> , <https://identifiers.org/uniprot/B3KR49> , <https://identifiers.org/uniprot/E9PRH7> , <https://identifiers.org/uniprot/L7RXH5> , <https://identifiers.org/uniprot/E9PJF0> , <https://identifiers.org/uniprot/E9PBK7> , <https://identifiers.org/uniprot/P27361> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/ddbf4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PBK7> , <http://purl.uniprot.org/uniprot/B3KR49> , <http://purl.uniprot.org/uniprot/L7RXH5> , <http://purl.uniprot.org/uniprot/H0YDH9> , <http://purl.uniprot.org/uniprot/E9PJF0> , <http://purl.uniprot.org/uniprot/E9PQW4> , <http://purl.uniprot.org/uniprot/P27361> , <http://purl.uniprot.org/uniprot/H0YEX6> , <http://purl.uniprot.org/uniprot/E9PRH7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5595> .

<https://identifiers.org/uniprot/P19838>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "NF-KB" ;
        dc:identifier       <https://identifiers.org/uniprot/P19838> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P19838" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id6d2597b1> , <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id843a87eb> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000109320> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4790> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFKB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D6RC45> , <https://identifiers.org/uniprot/A0A8V8TLB2> , <https://identifiers.org/uniprot/P19838> , <https://identifiers.org/uniprot/D6RH30> , <https://identifiers.org/uniprot/A0A494C157> , <https://identifiers.org/uniprot/A0A494C1E9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/d9409> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TLB2> , <http://purl.uniprot.org/uniprot/A0A494C1E9> , <http://purl.uniprot.org/uniprot/D6RH30> , <http://purl.uniprot.org/uniprot/A0A494C157> , <http://purl.uniprot.org/uniprot/D6RC45> , <http://purl.uniprot.org/uniprot/P19838> ;
        foaf:page           <http://www.uniprot.org/uniprot/P19838> .

<https://identifiers.org/ensembl/ENSG00000154229>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PRKCA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000154229> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000154229" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idbab35e73> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id6d2597b1> , <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idded89963> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000154229> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5578> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKCA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/L7RSM7> , <https://identifiers.org/uniprot/J3KN97> , <https://identifiers.org/uniprot/P17252> , <https://identifiers.org/uniprot/J3KRN5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14912643> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/c2d9e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/L7RSM7> , <http://purl.uniprot.org/uniprot/P17252> , <http://purl.uniprot.org/uniprot/J3KN97> , <http://purl.uniprot.org/uniprot/J3KRN5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000154229> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id93d57e1c>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id93d57e1c> ;
        wp:participants   <https://identifiers.org/ncbigene/7173> .

<https://identifiers.org/pubchem.compound/167195>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "131 Iodide" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XMBWDFGMSWQBCA-RNFDNDRNSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/167195> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "167195" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/146281> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XMBWDFGMSWQBCA-RNFDNDRNSA-M> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID167195> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27259563> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/af9f2> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/fb5f6> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/e01d0> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=167195> .

<https://identifiers.org/ncbigene/7253>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TSHR" ;
        dc:identifier       <https://identifiers.org/ncbigene/7253> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7253" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/f9073> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000165409> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7253> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TSHR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A1B0GUJ5> , <https://identifiers.org/uniprot/P16473> , <https://identifiers.org/uniprot/A0A2R8Y709> , <https://identifiers.org/uniprot/G3V381> , <https://identifiers.org/uniprot/A0A0A0MTJ0> , <https://identifiers.org/uniprot/Q0VAP8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/dbcc5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A1B0GUJ5> , <http://purl.uniprot.org/uniprot/A0A2R8Y709> , <http://purl.uniprot.org/uniprot/P16473> , <http://purl.uniprot.org/uniprot/A0A0A0MTJ0> , <http://purl.uniprot.org/uniprot/G3V381> , <http://purl.uniprot.org/uniprot/Q0VAP8> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7253> .

<https://identifiers.org/pubmed/221813>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "221813" ;
        dcterms:isPartOf    <https://identifiers.org/ncbigene/7038> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/221813> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id6d2597b1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id6d2597b1> ;
        wp:participants   <https://identifiers.org/uniprot/P19838> , <https://identifiers.org/ensembl/ENSG00000154229> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154229> ;
        wp:target         <https://identifiers.org/uniprot/P19838> .

<https://identifiers.org/ncbigene/2002>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ELK1" ;
        dc:identifier       <https://identifiers.org/ncbigene/2002> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "2002" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/ida5f6ca67> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000126767> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2002> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ELK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P19419> , <https://identifiers.org/uniprot/A0A024R1A7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/a84bc> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P19419> , <http://purl.uniprot.org/uniprot/A0A024R1A7> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/2002> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/e58fe>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/e58fe> ;
        wp:participants   <https://identifiers.org/ncbigene/7173> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/a5bbe> ;
        wp:source         <https://identifiers.org/ncbigene/7173> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/a5bbe> .

<https://identifiers.org/uniprot/P04049>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RAF1" ;
        dc:identifier       <https://identifiers.org/uniprot/P04049> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P04049" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idded89963> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000132155> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5894> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RAF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KS16> , <https://identifiers.org/uniprot/A0A8I5KUW4> , <https://identifiers.org/uniprot/A0A8I5KTK4> , <https://identifiers.org/uniprot/A0A0B4J1W9> , <https://identifiers.org/uniprot/A0A8I5KT32> , <https://identifiers.org/uniprot/A0A8I5KX50> , <https://identifiers.org/uniprot/A0A8I5KWF7> , <https://identifiers.org/uniprot/A0A8I5KWS9> , <https://identifiers.org/uniprot/A0A8I5KW44> , <https://identifiers.org/uniprot/A0A8I5KQV4> , <https://identifiers.org/uniprot/A0A8I5KSV6> , <https://identifiers.org/uniprot/A0A8I5KYC4> , <https://identifiers.org/uniprot/A0A8I5KR46> , <https://identifiers.org/uniprot/A0A8I5KWA9> , <https://identifiers.org/uniprot/P04049> , <https://identifiers.org/uniprot/A0A8I5KQ33> , <https://identifiers.org/uniprot/A0A8I5KTA5> , <https://identifiers.org/uniprot/A0A8I5KSB0> , <https://identifiers.org/uniprot/A0A8I5QKZ6> , <https://identifiers.org/uniprot/H7C155> , <https://identifiers.org/uniprot/A0A0S2Z4L5> , <https://identifiers.org/uniprot/A0A8I5KSM4> , <https://identifiers.org/uniprot/A0A8I5QJG5> , <https://identifiers.org/uniprot/A0A8I5QKU8> , <https://identifiers.org/uniprot/A0A0S2Z559> , <https://identifiers.org/uniprot/A0A8I5KRD1> , <https://identifiers.org/uniprot/L7RRS6> , <https://identifiers.org/uniprot/A0A8I5KYP5> , <https://identifiers.org/uniprot/A0A8I5KSI1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/bf17e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0S2Z4L5> , <http://purl.uniprot.org/uniprot/A0A0S2Z559> , <http://purl.uniprot.org/uniprot/A0A8I5KYC4> , <http://purl.uniprot.org/uniprot/A0A8I5KSB0> , <http://purl.uniprot.org/uniprot/A0A8I5KQV4> , <http://purl.uniprot.org/uniprot/A0A8I5KX50> , <http://purl.uniprot.org/uniprot/A0A8I5KSM4> , <http://purl.uniprot.org/uniprot/A0A8I5KT32> , <http://purl.uniprot.org/uniprot/A0A8I5KSV6> , <http://purl.uniprot.org/uniprot/A0A8I5KS16> , <http://purl.uniprot.org/uniprot/A0A8I5KWF7> , <http://purl.uniprot.org/uniprot/A0A8I5KR46> , <http://purl.uniprot.org/uniprot/A0A8I5QJG5> , <http://purl.uniprot.org/uniprot/A0A8I5KUW4> , <http://purl.uniprot.org/uniprot/A0A8I5KSI1> , <http://purl.uniprot.org/uniprot/A0A8I5KTK4> , <http://purl.uniprot.org/uniprot/A0A8I5KYP5> , <http://purl.uniprot.org/uniprot/H7C155> , <http://purl.uniprot.org/uniprot/A0A8I5QKZ6> , <http://purl.uniprot.org/uniprot/A0A8I5KWS9> , <http://purl.uniprot.org/uniprot/A0A8I5KWA9> , <http://purl.uniprot.org/uniprot/A0A8I5KQ33> , <http://purl.uniprot.org/uniprot/A0A8I5KW44> , <http://purl.uniprot.org/uniprot/A0A0B4J1W9> , <http://purl.uniprot.org/uniprot/L7RRS6> , <http://purl.uniprot.org/uniprot/A0A8I5KRD1> , <http://purl.uniprot.org/uniprot/P04049> , <http://purl.uniprot.org/uniprot/A0A8I5KTA5> , <http://purl.uniprot.org/uniprot/A0A8I5QKU8> ;
        foaf:page           <http://www.uniprot.org/uniprot/P04049> .

<https://identifiers.org/ncbigene/7038>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "Thyruglobulin (Tg)" ;
        dc:identifier       <https://identifiers.org/ncbigene/7038> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7038" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/a5bbe> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        dcterms:references  <https://identifiers.org/pubmed/221813> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000042832> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7038> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01266> , <https://identifiers.org/uniprot/H0YBJ2> , <https://identifiers.org/uniprot/E5RG33> , <https://identifiers.org/uniprot/H0YBQ6> , <https://identifiers.org/uniprot/H0YBR7> , <https://identifiers.org/uniprot/E7EVM0> , <https://identifiers.org/uniprot/H0YBC5> , <https://identifiers.org/uniprot/H0YB42> , <https://identifiers.org/uniprot/H0YBY1> , <https://identifiers.org/uniprot/H0YBL4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/d7d5b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E7EVM0> , <http://purl.uniprot.org/uniprot/H0YBY1> , <http://purl.uniprot.org/uniprot/E5RG33> , <http://purl.uniprot.org/uniprot/H0YBL4> , <http://purl.uniprot.org/uniprot/H0YBR7> , <http://purl.uniprot.org/uniprot/H0YBQ6> , <http://purl.uniprot.org/uniprot/H0YB42> , <http://purl.uniprot.org/uniprot/H0YBC5> , <http://purl.uniprot.org/uniprot/P01266> , <http://purl.uniprot.org/uniprot/H0YBJ2> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7038> .

<https://identifiers.org/uniprot/P61224>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RAP1B" ;
        dc:identifier       <https://identifiers.org/uniprot/P61224> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P61224" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000127314> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5908> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RAP1B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5GZG1> , <https://identifiers.org/uniprot/F5GYB5> , <https://identifiers.org/uniprot/F5GX62> , <https://identifiers.org/uniprot/F5H7Y6> , <https://identifiers.org/uniprot/F5H491> , <https://identifiers.org/uniprot/B7ZB78> , <https://identifiers.org/uniprot/F5GYH7> , <https://identifiers.org/uniprot/F5H4H0> , <https://identifiers.org/uniprot/A0A024RB87> , <https://identifiers.org/uniprot/P61224> , <https://identifiers.org/uniprot/F5GWU8> , <https://identifiers.org/uniprot/E7ESV4> , <https://identifiers.org/uniprot/F5H0B7> , <https://identifiers.org/uniprot/F5H500> , <https://identifiers.org/uniprot/F5H6R7> , <https://identifiers.org/uniprot/F5H004> , <https://identifiers.org/uniprot/F5H823> , <https://identifiers.org/uniprot/F8WBC0> , <https://identifiers.org/uniprot/F5H077> , <https://identifiers.org/uniprot/F5H0S2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/a05c9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F5H0B7> , <http://purl.uniprot.org/uniprot/F5H500> , <http://purl.uniprot.org/uniprot/P61224> , <http://purl.uniprot.org/uniprot/F5GZG1> , <http://purl.uniprot.org/uniprot/B7ZB78> , <http://purl.uniprot.org/uniprot/F5H7Y6> , <http://purl.uniprot.org/uniprot/F5GWU8> , <http://purl.uniprot.org/uniprot/F5H077> , <http://purl.uniprot.org/uniprot/F8WBC0> , <http://purl.uniprot.org/uniprot/F5H6R7> , <http://purl.uniprot.org/uniprot/F5H4H0> , <http://purl.uniprot.org/uniprot/F5GYH7> , <http://purl.uniprot.org/uniprot/F5H823> , <http://purl.uniprot.org/uniprot/F5GYB5> , <http://purl.uniprot.org/uniprot/E7ESV4> , <http://purl.uniprot.org/uniprot/F5H004> , <http://purl.uniprot.org/uniprot/F5H491> , <http://purl.uniprot.org/uniprot/F5GX62> , <http://purl.uniprot.org/uniprot/F5H0S2> , <http://purl.uniprot.org/uniprot/A0A024RB87> ;
        foaf:page           <http://www.uniprot.org/uniprot/P61224> .

<https://identifiers.org/ensembl/ENSG00000162409>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PRKAAK2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000162409> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000162409" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000162409> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5563> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKAA2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P54646> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030757> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/eef2f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P54646> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000162409> .

<https://identifiers.org/ensembl/ENSG00000225697>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SLC26A6" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000225697> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000225697" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000225697> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/65010> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SLC26A6> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C291> , <https://identifiers.org/uniprot/C9J6Y3> , <https://identifiers.org/uniprot/C9JKR6> , <https://identifiers.org/uniprot/A0A0C4DFT5> , <https://identifiers.org/uniprot/Q9BXS9> , <https://identifiers.org/uniprot/G3XAC1> , <https://identifiers.org/uniprot/H7BZJ6> , <https://identifiers.org/uniprot/H7BZB1> , <https://identifiers.org/uniprot/H7BZ36> , <https://identifiers.org/uniprot/F8W9I8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q7390822> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/bd79b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9BXS9> , <http://purl.uniprot.org/uniprot/C9JKR6> , <http://purl.uniprot.org/uniprot/C9J6Y3> , <http://purl.uniprot.org/uniprot/H7BZB1> , <http://purl.uniprot.org/uniprot/H7BZJ6> , <http://purl.uniprot.org/uniprot/A0A0C4DFT5> , <http://purl.uniprot.org/uniprot/F8W9I8> , <http://purl.uniprot.org/uniprot/G3XAC1> , <http://purl.uniprot.org/uniprot/H7C291> , <http://purl.uniprot.org/uniprot/H7BZ36> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000225697> .

<https://identifiers.org/ncbigene/5594>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ERK2" ;
        dc:identifier       <https://identifiers.org/ncbigene/5594> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "5594" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5594> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q1HBJ4> , <https://identifiers.org/uniprot/P28482> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/ed379> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28482> , <http://purl.uniprot.org/uniprot/Q1HBJ4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/5594> .

<https://identifiers.org/ncbigene/7173>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "Thyroidperoxidase" ;
        dc:identifier       <https://identifiers.org/ncbigene/7173> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "7173" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id17eabccc> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/e58fe> , <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id93d57e1c> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115705> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7173> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TPO> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C5B6> , <https://identifiers.org/uniprot/H7C1F5> , <https://identifiers.org/uniprot/C9J511> , <https://identifiers.org/uniprot/E9PFM6> , <https://identifiers.org/uniprot/P07202> , <https://identifiers.org/uniprot/H0Y6H4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/a85d9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9J511> , <http://purl.uniprot.org/uniprot/H0Y6H4> , <http://purl.uniprot.org/uniprot/H7C1F5> , <http://purl.uniprot.org/uniprot/H7C5B6> , <http://purl.uniprot.org/uniprot/E9PFM6> , <http://purl.uniprot.org/uniprot/P07202> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/7173> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1981&oldid=139940>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/hmdb/HMDB0000158>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "L-Tyrosine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/OUYCCCASQSFEME-QMMMGPOBSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000158> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000158" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/a5bbe> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17895> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5833> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000158> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/OUYCCCASQSFEME-QMMMGPOBSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00082> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6057> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q188017> , <http://www.wikidata.org/entity/Q106345477> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/bfddd> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000158> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/ensembl/ENSG00000126934>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MAP2K2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000126934> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000126934" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000126934> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5605> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAP2K2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/M0R1B6> , <https://identifiers.org/uniprot/P36507> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030794> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/c1479> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/M0R1B6> , <http://purl.uniprot.org/uniprot/P36507> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000126934> .

<https://identifiers.org/hmdb/HMDB0000058>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "cAMP" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/IVOMOUWHDPKRLL-KQYNXXCUSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000058> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000058" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id3e42b5d9> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17489> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5851> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000058> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/IVOMOUWHDPKRLL-KQYNXXCUSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00575> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6076> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q210041> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/d9939> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000058> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idded89963>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/idded89963> ;
        wp:participants   <https://identifiers.org/uniprot/P04049> , <https://identifiers.org/ensembl/ENSG00000154229> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000154229> ;
        wp:target         <https://identifiers.org/uniprot/P04049> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/dca29>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/dca29> ;
        wp:participants   <https://identifiers.org/ncbigene/1081> , <https://identifiers.org/ncbigene/7200> ;
        wp:source         <https://identifiers.org/ncbigene/7200> ;
        wp:target         <https://identifiers.org/ncbigene/1081> .

<https://identifiers.org/ensembl/ENSG00000243989>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ADCY1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000243989> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000243989" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000243989> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/95> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACY1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A1B0GU86> , <https://identifiers.org/uniprot/A0A1B0GVZ3> , <https://identifiers.org/uniprot/Q03154> , <https://identifiers.org/uniprot/A0A1B0GUZ4> , <https://identifiers.org/uniprot/A0A1B0GVG0> , <https://identifiers.org/uniprot/A0A1B0GU36> , <https://identifiers.org/uniprot/F8WC59> , <https://identifiers.org/uniprot/A0A1B0GVF7> , <https://identifiers.org/uniprot/C9JYZ0> , <https://identifiers.org/uniprot/A0A1B0GTG3> , <https://identifiers.org/uniprot/V9HWA0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17080560> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/ae67b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A1B0GTG3> , <http://purl.uniprot.org/uniprot/A0A1B0GU86> , <http://purl.uniprot.org/uniprot/A0A1B0GUZ4> , <http://purl.uniprot.org/uniprot/A0A1B0GVZ3> , <http://purl.uniprot.org/uniprot/Q03154> , <http://purl.uniprot.org/uniprot/V9HWA0> , <http://purl.uniprot.org/uniprot/F8WC59> , <http://purl.uniprot.org/uniprot/A0A1B0GU36> , <http://purl.uniprot.org/uniprot/C9JYZ0> , <http://purl.uniprot.org/uniprot/A0A1B0GVF7> , <http://purl.uniprot.org/uniprot/A0A1B0GVG0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000243989> .

<https://identifiers.org/chebi/CHEBI:16240>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "H202" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MHAJPDPJQMAIIY-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:16240> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:16240" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id17eabccc> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16240> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/763> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0003125> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MHAJPDPJQMAIIY-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00027> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID784> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID22326046> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q171877> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/d89ce> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16240> .

<https://identifiers.org/wikipathways/WP1981_r139940>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP1981> ;
        dc:source              "WikiPathways" ;
        dc:title               "Thyroxine (thyroid hormone) production"@en ;
        dcterms:description    "Thyroxine hormone is produced in the thyroid gland from tyrosine and iodine. Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus. It stimulates the production of thyroid-stimulating hormone (TSH) in the anterior pituitary gland, which affects the thyroid-stimulating hormone receptor (TSHR). Iodine is captured by a hydrogen peroxide trap procuced by thyroid peroxidase and added to the 3' and 5' postitions of tyrosine. This can either be free tyrosine or a tyrosine residue in thyroglobuline. After the multiple iodination steps this produces T3 and T4. \nThe production of the thyroid hormones thyroxine (T4),tri-iodothyronine (T3) and reverse T3 (rT3) is dependent on the organification of iodine into thyroglobulin (Tg), the major protein product of the thyroid (2). This involves thyroid peroxidase catalyzed iodination of tyrosine residues in Tg to form mono- and di-iodotyrosines and their subsequent crosslinking to form the iodothyronines T3 and T4.\n\nIodine 131 is an important radioactive fallout product. It was released in the atmosphere after nuclear tests and after nuclear incidents like at Tchernobyl and Fukushima. Since the iodine is concentrated in the thyroid glant as a substrate for the process described here non-radioactive iodine 127 is given as competitor to people exposed." ;
        dcterms:identifier     "WP1981" ;
        dcterms:references     <https://identifiers.org/pubmed/7871153> , <https://identifiers.org/pubmed/30886364> ;
        cito:cites             <https://identifiers.org/pubmed/30886364> , <https://identifiers.org/pubmed/221813> , <https://identifiers.org/pubmed/7871153> ;
        wp:diseaseOntologyTag  obo:DOID_50 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP1981_r139940> ;
        wp:ontologyTag         obo:DOID_50 , obo:PW_0000501 , wp:Curation:AnalysisCollection , wp:Curation:Micronutrients ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000501 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1981&oldid=139940> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1981&oldid=139940> ;
        foaf:page              <http://www.wikipathways.org/instance/WP1981_r139940> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/a5bbe>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/a5bbe> ;
        wp:participants   <https://identifiers.org/ncbigene/7038> , <https://identifiers.org/hmdb/HMDB0000158> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0000158> ;
        wp:target         <https://identifiers.org/ncbigene/7038> .

<https://identifiers.org/ensembl/ENSG00000140279>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "DUOX2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000140279> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000140279" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Complex/c97d4> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000140279> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/50506> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DUOX2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/X6RAN8> , <https://identifiers.org/uniprot/Q9NRD8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18039811> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/e9983> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9NRD8> , <http://purl.uniprot.org/uniprot/X6RAN8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000140279> .

<https://identifiers.org/ensembl/ENSG00000171365>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CLC5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000171365> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000171365" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171365> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1184> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CLCN5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P51795> , <https://identifiers.org/uniprot/V9GYG7> , <https://identifiers.org/uniprot/A0A2R8YF14> , <https://identifiers.org/uniprot/A0A2R8YGW0> , <https://identifiers.org/uniprot/A0A2R8Y6C4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17862044> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/fd218> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A2R8YF14> , <http://purl.uniprot.org/uniprot/P51795> , <http://purl.uniprot.org/uniprot/V9GYG7> , <http://purl.uniprot.org/uniprot/A0A2R8YGW0> , <http://purl.uniprot.org/uniprot/A0A2R8Y6C4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000171365> .

<https://identifiers.org/uniprot/P62834>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RAP1A" ;
        dc:identifier       <https://identifiers.org/uniprot/P62834> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P62834" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000116473> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5906> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RAP1A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A8KAH9> , <https://identifiers.org/uniprot/P62834> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/ded77> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A8KAH9> , <http://purl.uniprot.org/uniprot/P62834> ;
        foaf:page           <http://www.uniprot.org/uniprot/P62834> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/ComplexBinding/c97d4>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Group/c97d4> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000140279> , <https://identifiers.org/ensembl/ENSG00000137857> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Complex/c97d4> .

<https://identifiers.org/ensembl/ENSG00000169032>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000169032> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000169032" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000169032> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5604> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAP2K1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5QJC1> , <https://identifiers.org/uniprot/A4QPA9> , <https://identifiers.org/uniprot/A0A8I5QJL9> , <https://identifiers.org/uniprot/A0A8I5KXN4> , <https://identifiers.org/uniprot/B4DFY5> , <https://identifiers.org/uniprot/A0A8I5QJP8> , <https://identifiers.org/uniprot/Q02750> , <https://identifiers.org/uniprot/H3BRW9> , <https://identifiers.org/uniprot/A0A8I5QJ96> , <https://identifiers.org/uniprot/A0A8I5KYB4> , <https://identifiers.org/uniprot/A0A8I5KRX5> , <https://identifiers.org/uniprot/A0A8I5KYS7> , <https://identifiers.org/uniprot/A0A8I5KVF6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030793> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/dbc4b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KXN4> , <http://purl.uniprot.org/uniprot/A0A8I5KVF6> , <http://purl.uniprot.org/uniprot/A0A8I5KRX5> , <http://purl.uniprot.org/uniprot/A0A8I5QJ96> , <http://purl.uniprot.org/uniprot/A0A8I5QJL9> , <http://purl.uniprot.org/uniprot/A0A8I5KYS7> , <http://purl.uniprot.org/uniprot/A0A8I5QJC1> , <http://purl.uniprot.org/uniprot/H3BRW9> , <http://purl.uniprot.org/uniprot/B4DFY5> , <http://purl.uniprot.org/uniprot/A0A8I5QJP8> , <http://purl.uniprot.org/uniprot/A4QPA9> , <http://purl.uniprot.org/uniprot/A0A8I5KYB4> , <http://purl.uniprot.org/uniprot/Q02750> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000169032> .

<https://identifiers.org/uniprot/P51178>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PLC" ;
        dc:identifier       <https://identifiers.org/uniprot/P51178> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P51178" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000187091> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5333> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PLCD1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P51178> , <https://identifiers.org/uniprot/A0A384MR47> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/f3466> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P51178> , <http://purl.uniprot.org/uniprot/A0A384MR47> ;
        foaf:page           <http://www.uniprot.org/uniprot/P51178> .

<https://identifiers.org/uniprot/P16220>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CREB1" ;
        dc:identifier       <https://identifiers.org/uniprot/P16220> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P16220" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id6803f11c> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118260> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1385> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CREB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E7EWP8> , <https://identifiers.org/uniprot/C9J4L5> , <https://identifiers.org/uniprot/C9JCI4> , <https://identifiers.org/uniprot/C9J276> , <https://identifiers.org/uniprot/Q5U0J5> , <https://identifiers.org/uniprot/C9J896> , <https://identifiers.org/uniprot/H7C1R5> , <https://identifiers.org/uniprot/Q53X93> , <https://identifiers.org/uniprot/P16220> , <https://identifiers.org/uniprot/H7C3I0> , <https://identifiers.org/uniprot/C9JBT4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/b5967> , <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/f59e4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9J276> , <http://purl.uniprot.org/uniprot/P16220> , <http://purl.uniprot.org/uniprot/E7EWP8> , <http://purl.uniprot.org/uniprot/C9JCI4> , <http://purl.uniprot.org/uniprot/H7C1R5> , <http://purl.uniprot.org/uniprot/Q53X93> , <http://purl.uniprot.org/uniprot/C9J4L5> , <http://purl.uniprot.org/uniprot/H7C3I0> , <http://purl.uniprot.org/uniprot/C9JBT4> , <http://purl.uniprot.org/uniprot/Q5U0J5> , <http://purl.uniprot.org/uniprot/C9J896> ;
        foaf:page           <http://www.uniprot.org/uniprot/P16220> .

<https://identifiers.org/ensembl/ENSG00000132356>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PRKAA1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000132356> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000132356" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000132356> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5562> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKAA1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q96E92> , <https://identifiers.org/uniprot/Q13131> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030756> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/fc743> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q96E92> , <http://purl.uniprot.org/uniprot/Q13131> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000132356> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id6803f11c>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id6803f11c> ;
        wp:participants   <https://identifiers.org/uniprot/P16220> ;
        wp:source         <https://identifiers.org/uniprot/P16220> ;
        wp:target         <https://identifiers.org/uniprot/P16220> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/iddb5ca020>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/iddb5ca020> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:138527> , <https://identifiers.org/chebi/CHEBI:83416> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:83416> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:138527> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id843a87eb>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id843a87eb> ;
        wp:participants   <https://identifiers.org/uniprot/P19838> .

<https://identifiers.org/ncbigene/6528>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "SLC5A5" ;
        dc:identifier       <https://identifiers.org/ncbigene/6528> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "6528" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105641> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6528> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SLC5A5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q92911> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/d0c57> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q92911> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/6528> .

<https://identifiers.org/chebi/CHEBI:29108>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ca²⁺" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:29108> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:29108" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id45568e9d> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:29108> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/266> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000464> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BHPQYMZQTOCNFJ-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00076> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID271> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q23905776> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/a6aef> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29108> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/idbab35e73>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/idbab35e73> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000154229> , <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:18035> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000154229> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/Complex/c97d4>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Group/c97d4> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000140279> , <https://identifiers.org/ensembl/ENSG00000137857> .

<https://identifiers.org/ensembl/ENSG00000137857>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "DUOX1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000137857> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000137857" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Complex/c97d4> , <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137857> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/53905> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/DUOX1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YK19> , <https://identifiers.org/uniprot/H0YNR5> , <https://identifiers.org/uniprot/Q9NRD9> , <https://identifiers.org/uniprot/A0A804HKN9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18040723> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/e010b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A804HKN9> , <http://purl.uniprot.org/uniprot/Q9NRD9> , <http://purl.uniprot.org/uniprot/H0YNR5> , <http://purl.uniprot.org/uniprot/H0YK19> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000137857> .

<https://identifiers.org/hmdb/HMDB0000248>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Thyroxine (T4)" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XUIIKFGFIJCVMT-LBPRGKRZSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000248> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000248" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:18332> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5614> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000248> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XUIIKFGFIJCVMT-LBPRGKRZSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01829> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5819> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID25201348> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q773449> , <http://www.wikidata.org/entity/Q106345689> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP1981_r139940/DataNode/f95aa> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000248> .

<http://rdf.wikipathways.org/Pathway/WP1981_r139940/WP/Interaction/id3e42b5d9>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP1981_r139940> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP1981_r139940/Interaction/id3e42b5d9> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0000058> , <https://identifiers.org/hmdb/HMDB0001532> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0001532> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0000058> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1981&oldid=139940>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .
