@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000100030>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000100030> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000100030" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5594> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q1HBJ4> , <https://identifiers.org/uniprot/P28482> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15317730> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/b3596> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28482> , <http://purl.uniprot.org/uniprot/Q1HBJ4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000100030> .

<https://identifiers.org/uniprot/Q14973>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "NTCP" ;
        dc:identifier       <https://identifiers.org/uniprot/Q14973> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q14973" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id83d6f460> , <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100652> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6554> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SLC10A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q14973> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/cbf70> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q14973> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q14973> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/ide951a67>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/ide951a67> ;
        wp:participants   <https://identifiers.org/uniprot/P22455> , <https://identifiers.org/ensembl/ENSG00000162344> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000162344> ;
        wp:target         <https://identifiers.org/uniprot/P22455> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4c64cfdb>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id4c64cfdb> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000073734> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idccdd9e2e> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000073734> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idccdd9e2e> .

<https://identifiers.org/chebi/CHEBI:39026>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "LDL" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:39026> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:39026" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id7aee9551> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:39026> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q28749> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/a1845> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:39026> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id20c4881d>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id20c4881d> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:3098> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/e4575>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/e4575> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:47774> , <https://identifiers.org/chebi/CHEBI:16113> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:16113> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:47774> .

<https://identifiers.org/chebi/CHEBI:47774>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "LDL cholesterol" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:47774> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:47774" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/e4575> , <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:47774> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q75298271> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/f997b> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:47774> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id83d6f460>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id83d6f460> ;
        wp:participants   <https://identifiers.org/uniprot/Q14973> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id20c4881d> ;
        wp:source         <https://identifiers.org/uniprot/Q14973> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id20c4881d> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4389&oldid=140989>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/uniprot/Q12908>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "ASBT" ;
        dc:identifier       <https://identifiers.org/uniprot/Q12908> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q12908" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idd736ccfc> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id5c4dbb0f> , <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000125255> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6555> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SLC10A2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q12908> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/f9d48> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q12908> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q12908> .

<https://identifiers.org/wikipathways/WP197>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "De novo synthesis" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP197> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP197" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idbcdb6027> , <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/ef470> ;
        foaf:page           <https://www.wikipathways.org/instance/WP197> .

<https://identifiers.org/ensembl/ENSG00000114416>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "FXR1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000114416> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000114416" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id39d4d4b1> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idd7ef0789> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id52bc4826> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id29259dc9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000114416> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/8087> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FXR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TNP6> , <https://identifiers.org/uniprot/C9JY20> , <https://identifiers.org/uniprot/C9JZE0> , <https://identifiers.org/uniprot/B4DXZ6> , <https://identifiers.org/uniprot/A0A8V8TMQ1> , <https://identifiers.org/uniprot/E7EU85> , <https://identifiers.org/uniprot/P51114> , <https://identifiers.org/uniprot/C9JYQ6> , <https://identifiers.org/uniprot/C9IZ22> , <https://identifiers.org/uniprot/E9PFF5> , <https://identifiers.org/uniprot/A0A8V8TM97> , <https://identifiers.org/uniprot/C9JAJ4> , <https://identifiers.org/uniprot/C9J5B4> , <https://identifiers.org/uniprot/H7C4S4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18032729> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/b8394> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/d30fa> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TM97> , <http://purl.uniprot.org/uniprot/C9JYQ6> , <http://purl.uniprot.org/uniprot/P51114> , <http://purl.uniprot.org/uniprot/A0A8V8TNP6> , <http://purl.uniprot.org/uniprot/E9PFF5> , <http://purl.uniprot.org/uniprot/E7EU85> , <http://purl.uniprot.org/uniprot/B4DXZ6> , <http://purl.uniprot.org/uniprot/C9JY20> , <http://purl.uniprot.org/uniprot/C9IZ22> , <http://purl.uniprot.org/uniprot/H7C4S4> , <http://purl.uniprot.org/uniprot/C9JZE0> , <http://purl.uniprot.org/uniprot/C9J5B4> , <http://purl.uniprot.org/uniprot/A0A8V8TMQ1> , <http://purl.uniprot.org/uniprot/C9JAJ4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000114416> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idd7ef0789>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/idd7ef0789> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000162344> , <https://identifiers.org/ensembl/ENSG00000114416> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000114416> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000162344> .

<https://identifiers.org/ensembl/ENSG00000138075>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ABCG5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000138075> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000138075" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000138075> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/64240> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ABCG5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9H222> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18045622> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/fed5f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9H222> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000138075> .

<https://identifiers.org/chebi/CHEBI:16113>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Cholesterol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/HVYWMOMLDIMFJA-DPAQBDIFSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:16113> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:16113" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/e4575> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4277b65> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id7aee9551> , <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idbcdb6027> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16113> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5775> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000067> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/HVYWMOMLDIMFJA-DPAQBDIFSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00187> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST01010001> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5997> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q43656> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/f54f0> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST01010001> , <https://swisslipids.org/rdf/SLM_000000287> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16113> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id39d4d4b1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id39d4d4b1> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000114416> , <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000114416> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4277b65>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id4277b65> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:3098> , <https://identifiers.org/chebi/CHEBI:16113> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:16113> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:3098> .

<https://identifiers.org/ensembl/ENSG00000162344>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "FGF19" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000162344> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000162344" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/ide951a67> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idd7ef0789> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000162344> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/9965> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FGF19> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O95750> , <https://identifiers.org/uniprot/A0A7U3L4E7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18034920> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/d2720> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7U3L4E7> , <http://purl.uniprot.org/uniprot/O95750> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000162344> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4389&oldid=140989>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/wikipathways/WP4389>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4389_r140989> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id5c4dbb0f>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id5c4dbb0f> ;
        wp:participants   <https://identifiers.org/uniprot/Q12908> , <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:target         <https://identifiers.org/uniprot/Q12908> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id52bc4826>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id52bc4826> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000114416> , <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000114416> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idbcdb6027>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/idbcdb6027> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:16113> , <https://identifiers.org/wikipathways/WP197> ;
        wp:source         <https://identifiers.org/wikipathways/WP197> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:16113> .

<https://identifiers.org/wikipathways/WP4389_r140989>
        rdf:type                wp:Pathway , skos:Collection ;
        dc:identifier           <https://identifiers.org/wikipathways/WP4389> ;
        dc:source               "WikiPathways" ;
        dc:title                "Bile acid synthesis and enterohepatic circulation "@en ;
        dcterms:description     "Bile Acid Synthesis and Enterohepathic Circulation. \nIn hepatocytes, cholesterol is acquired through de novo synthesis as well as receptor-mediated endocytosis of cholesterol-rich lipoproteins. Cholesterol is eliminated through bile acid synthesis and secretion. The first (and rate-limiting) step in cholesterol conversion  to bile acids is catalyzed by CYP7A1. Bile acids are then secreted into the bile via ABCB11 and released into the small intestine. The majority of bile acids are re-absorbed into the enterocytes via ASBT and transported back to the liver via portal circulation via NTCP.  In the hepatocyte, bile acids activate FXR, which inhibits CYP7A1. In the small intestine, bile acids also activate FXR to induce FGF15, which subsequently binds and activates FGFR4, leading to inhibition of CYP7A1, partially via ERK signaling.\nBased on figure 1 in [Wang et al](https://www.ncbi.nlm.nih.gov/pubmed/29653253).\n\n " ;
        dcterms:identifier      "WP4389" ;
        dcterms:references      <https://identifiers.org/pubmed/29653253> ;
        cito:cites              <https://identifiers.org/pubmed/29653253> ;
        wp:cellTypeOntologyTag  obo:CL_0000584 , obo:CL_0000182 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP4389_r140989> ;
        wp:ontologyTag          obo:CL_0000182 , wp:Curation:ONTOX , obo:CL_0000584 , obo:PW_0000039 , wp:Curation:AnalysisCollection ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000039 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4389&oldid=140989> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4389&oldid=140989> ;
        foaf:page               <http://www.wikipathways.org/instance/WP4389_r140989> .

<https://identifiers.org/ensembl/ENSG00000073734>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ABCB11" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000073734> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000073734" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4c64cfdb> , <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000073734> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/8647> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ABCB11> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O95342> , <https://identifiers.org/uniprot/H7C486> , <https://identifiers.org/uniprot/A0A3B3ISD4> , <https://identifiers.org/uniprot/A0A3B3IS78> , <https://identifiers.org/uniprot/A0A3B3ITV9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/fb374> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H7C486> , <http://purl.uniprot.org/uniprot/A0A3B3ITV9> , <http://purl.uniprot.org/uniprot/A0A3B3ISD4> , <http://purl.uniprot.org/uniprot/A0A3B3IS78> , <http://purl.uniprot.org/uniprot/O95342> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000073734> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id7aee9551>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id7aee9551> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:16113> , <https://identifiers.org/chebi/CHEBI:39026> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:39026> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:16113> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id87048896>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id87048896> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000167910> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4277b65> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000167910> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4277b65> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idccdd9e2e>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/idccdd9e2e> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:3098> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id65b55064>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id65b55064> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000130164> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id7aee9551> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000130164> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id7aee9551> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idd736ccfc>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/idd736ccfc> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:3098> , <https://identifiers.org/uniprot/Q12908> ;
        wp:source         <https://identifiers.org/uniprot/Q12908> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:3098> .

<https://identifiers.org/ensembl/ENSG00000143921>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ABCG8" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000143921> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000143921" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000143921> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/64241> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ABCG8> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9H221> , <https://identifiers.org/uniprot/A0A2R8Y6M1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18045623> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/cc25c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9H221> , <http://purl.uniprot.org/uniprot/A0A2R8Y6M1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000143921> .

<https://identifiers.org/pubmed/29653253>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "29653253" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/29653253> .

<https://identifiers.org/chebi/CHEBI:3098>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Bile acid" , "Bile Acid" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:3098> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:3098" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id5c4dbb0f> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id52bc4826> , <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idd736ccfc> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/idccdd9e2e> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id20c4881d> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id39d4d4b1> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id4277b65> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:3098> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q59191092> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/a9220> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/f2aeb> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/a42f3> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3098> .

<https://identifiers.org/ensembl/ENSG00000167910>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CYP7A1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000167910> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000167910" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id87048896> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id29259dc9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000167910> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1581> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP7A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P22680> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14907373> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/ef30c> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P22680> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000167910> .

<https://identifiers.org/uniprot/P22455>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "FGFR4" ;
        dc:identifier       <https://identifiers.org/uniprot/P22455> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P22455" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/ide951a67> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000160867> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2264> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FGFR4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B5A964> , <https://identifiers.org/uniprot/E7EWF4> , <https://identifiers.org/uniprot/P22455> , <https://identifiers.org/uniprot/D6RG06> , <https://identifiers.org/uniprot/D6R9V0> , <https://identifiers.org/uniprot/D6RJD4> , <https://identifiers.org/uniprot/H0Y9P2> , <https://identifiers.org/uniprot/J3KPQ0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/d8533> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H0Y9P2> , <http://purl.uniprot.org/uniprot/P22455> , <http://purl.uniprot.org/uniprot/J3KPQ0> , <http://purl.uniprot.org/uniprot/B5A964> , <http://purl.uniprot.org/uniprot/E7EWF4> , <http://purl.uniprot.org/uniprot/D6R9V0> , <http://purl.uniprot.org/uniprot/D6RJD4> , <http://purl.uniprot.org/uniprot/D6RG06> ;
        foaf:page           <http://www.uniprot.org/uniprot/P22455> .

<https://identifiers.org/ensembl/ENSG00000102882>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000102882> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000102882" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102882> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YEX6> , <https://identifiers.org/uniprot/E9PBK7> , <https://identifiers.org/uniprot/L7RXH5> , <https://identifiers.org/uniprot/B3KR49> , <https://identifiers.org/uniprot/P27361> , <https://identifiers.org/uniprot/H0YDH9> , <https://identifiers.org/uniprot/E9PRH7> , <https://identifiers.org/uniprot/E9PQW4> , <https://identifiers.org/uniprot/E9PJF0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15328839> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/c3b3e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PQW4> , <http://purl.uniprot.org/uniprot/L7RXH5> , <http://purl.uniprot.org/uniprot/H0YEX6> , <http://purl.uniprot.org/uniprot/H0YDH9> , <http://purl.uniprot.org/uniprot/E9PJF0> , <http://purl.uniprot.org/uniprot/E9PBK7> , <http://purl.uniprot.org/uniprot/P27361> , <http://purl.uniprot.org/uniprot/B3KR49> , <http://purl.uniprot.org/uniprot/E9PRH7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000102882> .

<https://identifiers.org/ensembl/ENSG00000130164>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "LDLR" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000130164> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000130164" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4389_r140989> , <http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id65b55064> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000130164> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3949> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/LDLR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3KMZ9> , <https://identifiers.org/uniprot/A0A024R7D5> , <https://identifiers.org/uniprot/H0YMD1> , <https://identifiers.org/uniprot/H0YM92> , <https://identifiers.org/uniprot/P01130> , <https://identifiers.org/uniprot/H0YMQ3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14872724> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4389_r140989/DataNode/cd9ef> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A024R7D5> , <http://purl.uniprot.org/uniprot/H0YMD1> , <http://purl.uniprot.org/uniprot/P01130> , <http://purl.uniprot.org/uniprot/H0YM92> , <http://purl.uniprot.org/uniprot/J3KMZ9> , <http://purl.uniprot.org/uniprot/H0YMQ3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000130164> .

<http://rdf.wikipathways.org/Pathway/WP4389_r140989/WP/Interaction/id29259dc9>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4389_r140989> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4389_r140989/Interaction/id29259dc9> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000167910> , <https://identifiers.org/ensembl/ENSG00000114416> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000114416> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000167910> .
