@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000163737>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PF4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000163737> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000163737" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000163737> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5196> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PF4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P02776> , <https://identifiers.org/uniprot/A0A8I5QJ57> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905359> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/eb84a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P02776> , <http://purl.uniprot.org/uniprot/A0A8I5QJ57> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000163737> .

<https://identifiers.org/uniprot/P16109>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "P-selectin" ;
        dc:identifier       <https://identifiers.org/uniprot/P16109> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P16109" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/da1ab_1> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/da1ab_2> , <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000174175> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6403> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SELP> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5R342> , <https://identifiers.org/uniprot/A0A024R8Y9> , <https://identifiers.org/uniprot/Q5R341> , <https://identifiers.org/uniprot/Q5R349> , <https://identifiers.org/uniprot/F6VVT6> , <https://identifiers.org/uniprot/Q5R345> , <https://identifiers.org/uniprot/P16109> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/b44f5> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/ba960> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A024R8Y9> , <http://purl.uniprot.org/uniprot/Q5R349> , <http://purl.uniprot.org/uniprot/P16109> , <http://purl.uniprot.org/uniprot/Q5R341> , <http://purl.uniprot.org/uniprot/Q5R345> , <http://purl.uniprot.org/uniprot/Q5R342> , <http://purl.uniprot.org/uniprot/F6VVT6> ;
        foaf:page           <http://www.uniprot.org/uniprot/P16109> .

<https://identifiers.org/pmc/PMC12799884>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC12799884" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4462> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC12799884> .

<http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/ida683a118_2>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4462_r139061/Interaction/ida683a118> ;
        wp:participants   <https://identifiers.org/uniprot/P29965> , <https://identifiers.org/ensembl/ENSG00000101017> ;
        wp:source         <https://identifiers.org/uniprot/P29965> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000101017> .

<http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/f0546_2>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4462_r139061/Interaction/f0546> ;
        wp:participants   <https://identifiers.org/uniprot/P25942> , <https://identifiers.org/ensembl/ENSG00000102245> ;
        wp:source         <https://identifiers.org/uniprot/P25942> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000102245> .

<https://identifiers.org/uniprot/B2R9N9>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "TLR7" ;
        dc:identifier       <https://identifiers.org/uniprot/B2R9N9> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "B2R9N9" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000196664> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/51284> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TLR7> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9NYK1> , <https://identifiers.org/uniprot/B2R9N9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/fad18> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9NYK1> , <http://purl.uniprot.org/uniprot/B2R9N9> ;
        foaf:page           <http://www.uniprot.org/uniprot/B2R9N9> .

<https://identifiers.org/pubmed/29348254>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "29348254" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/29348254> .

<https://identifiers.org/uniprot/O60603>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "TLR2" ;
        dc:identifier       <https://identifiers.org/uniprot/O60603> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "O60603" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137462> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7097> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TLR2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A2R8Y4N9> , <https://identifiers.org/uniprot/A0A0S2Z4S4> , <https://identifiers.org/uniprot/A0A0S2Z4L7> , <https://identifiers.org/uniprot/A0A2R8Y7R7> , <https://identifiers.org/uniprot/A0A2R8YHF6> , <https://identifiers.org/uniprot/O60603> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/cdc58> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A0S2Z4L7> , <http://purl.uniprot.org/uniprot/A0A2R8YHF6> , <http://purl.uniprot.org/uniprot/A0A0S2Z4S4> , <http://purl.uniprot.org/uniprot/O60603> , <http://purl.uniprot.org/uniprot/A0A2R8Y7R7> , <http://purl.uniprot.org/uniprot/A0A2R8Y4N9> ;
        foaf:page           <http://www.uniprot.org/uniprot/O60603> .

<https://identifiers.org/ensembl/ENSG00000007908>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "SELE" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000007908> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000007908" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000007908> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6401> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SELE> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5TI74> , <https://identifiers.org/uniprot/P16581> , <https://identifiers.org/uniprot/Q5TI72> , <https://identifiers.org/uniprot/Q5TI75> , <https://identifiers.org/uniprot/V9GYI4> , <https://identifiers.org/uniprot/Q5TI73> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20970089> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/b3aac> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5TI75> , <http://purl.uniprot.org/uniprot/P16581> , <http://purl.uniprot.org/uniprot/Q5TI73> , <http://purl.uniprot.org/uniprot/V9GYI4> , <http://purl.uniprot.org/uniprot/Q5TI74> , <http://purl.uniprot.org/uniprot/Q5TI72> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000007908> .

<http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/ida683a118_1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4462_r139061/Interaction/ida683a118> ;
        wp:participants   <https://identifiers.org/uniprot/P29965> , <https://identifiers.org/ensembl/ENSG00000101017> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000101017> ;
        wp:target         <https://identifiers.org/uniprot/P29965> .

<https://identifiers.org/pmc/PMC9154116>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC9154116" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4462> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9154116> .

<http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/f0546_1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4462_r139061/Interaction/f0546> ;
        wp:participants   <https://identifiers.org/uniprot/P25942> , <https://identifiers.org/ensembl/ENSG00000102245> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000102245> ;
        wp:target         <https://identifiers.org/uniprot/P25942> .

<https://identifiers.org/ensembl/ENSG00000102245>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CD40LG" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000102245> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000102245" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/f0546_1> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/f0546_2> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102245> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/959> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD40LG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q3L8U2> , <https://identifiers.org/uniprot/A0A8Q3WKP2> , <https://identifiers.org/uniprot/P29965> , <https://identifiers.org/uniprot/A0A8Q3WL88> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14897851> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/d96f8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8Q3WKP2> , <http://purl.uniprot.org/uniprot/P29965> , <http://purl.uniprot.org/uniprot/A0A8Q3WL88> , <http://purl.uniprot.org/uniprot/Q3L8U2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000102245> .

<https://identifiers.org/uniprot/O00206>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "TLR4" ;
        dc:identifier       <https://identifiers.org/uniprot/O00206> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "O00206" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136869> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7099> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TLR4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O00206> , <https://identifiers.org/uniprot/A0A2R8Y7P4> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/b145d> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/e088a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A2R8Y7P4> , <http://purl.uniprot.org/uniprot/O00206> ;
        foaf:page           <http://www.uniprot.org/uniprot/O00206> .

<https://identifiers.org/chebi/CHEBI:28790>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Serotonin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/QZAYGJVTTNCVMB-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:28790> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:28790" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:28790> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5013> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000259> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/QZAYGJVTTNCVMB-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00780> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5202> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q167934> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/c3a75> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28790> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4462&oldid=139061>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/pmc/PMC8431385>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC8431385" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4462> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC8431385> .

<https://identifiers.org/uniprot/Q14242>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "PSGL1" ;
        dc:identifier       <https://identifiers.org/uniprot/Q14242> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q14242" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/da1ab_1> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/da1ab_2> , <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000110876> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6404> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SELPLG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q14242> , <https://identifiers.org/uniprot/A0A0C4DFY0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/a92b1> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/e9ecb> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/a8f68> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q14242> , <http://purl.uniprot.org/uniprot/A0A0C4DFY0> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q14242> .

<http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/da1ab_2>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4462_r139061/Interaction/da1ab> ;
        wp:participants   <https://identifiers.org/uniprot/P16109> , <https://identifiers.org/uniprot/Q14242> ;
        wp:source         <https://identifiers.org/uniprot/P16109> ;
        wp:target         <https://identifiers.org/uniprot/Q14242> .

<https://identifiers.org/uniprot/P25942>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "CD40" ;
        dc:identifier       <https://identifiers.org/uniprot/P25942> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P25942" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/f0546_1> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/f0546_2> , <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000101017> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/958> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD40> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P25942> , <https://identifiers.org/uniprot/A0A8Q3SI60> , <https://identifiers.org/uniprot/A0A0S2Z3C7> , <https://identifiers.org/uniprot/A0A8Q3WKP7> , <https://identifiers.org/uniprot/H0YE23> , <https://identifiers.org/uniprot/A0A8Q3WKP3> , <https://identifiers.org/uniprot/A0A087X1D0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/b6449> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8Q3SI60> , <http://purl.uniprot.org/uniprot/A0A0S2Z3C7> , <http://purl.uniprot.org/uniprot/A0A8Q3WKP7> , <http://purl.uniprot.org/uniprot/A0A087X1D0> , <http://purl.uniprot.org/uniprot/P25942> , <http://purl.uniprot.org/uniprot/A0A8Q3WKP3> , <http://purl.uniprot.org/uniprot/H0YE23> ;
        foaf:page           <http://www.uniprot.org/uniprot/P25942> .

<https://identifiers.org/wikipathways/WP4462>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4462_r139061> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4462&oldid=139061>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/uniprot/P29965>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "CD40-L" ;
        dc:identifier       <https://identifiers.org/uniprot/P29965> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P29965" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/ida683a118_1> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/ida683a118_2> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102245> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/959> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD40LG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q3L8U2> , <https://identifiers.org/uniprot/A0A8Q3WKP2> , <https://identifiers.org/uniprot/A0A8Q3WL88> , <https://identifiers.org/uniprot/P29965> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/e3b9d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8Q3WKP2> , <http://purl.uniprot.org/uniprot/Q3L8U2> , <http://purl.uniprot.org/uniprot/A0A8Q3WL88> , <http://purl.uniprot.org/uniprot/P29965> ;
        foaf:page           <http://www.uniprot.org/uniprot/P29965> .

<https://identifiers.org/wikipathways/WP4462_r139061>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP4462> ;
        dc:source               "WikiPathways" ;
        dc:title                "Platelet-mediated interactions with vascular and circulating cells"@en ;
        dcterms:description     "This pathway describes platelet-mediated interactions with vascular or circulating cells. It is adapted from figure 2 in [Koupenova et al](https://www.ncbi.nlm.nih.gov/pubmed/29348254), in collaboration with Dr. Milka Koupenova. \n\nPlatelets interact with endothelial and immune cells in the circulation, and control the response to microbes, inflammatory stimuli, and vessel damage. \nThrough their TLRs or inflammatory signals, platelets can change their surface expression and release their granule content and in that way interact with different immune cells.\nPlatelets form heterotypic aggregates with other immune cells and initiate innate immune responses in the presence of TLR agonists and viruses (encephalomyocarditis virus, coxsackievirus B, dengue, flu and HIV). \nPlatelets can also interact with dendritic cells through P-selectin, and activate them to become antigen-presenting through their CD154. \nPlatelets engage the adaptive immune response by releasing their granule content which leads to IgG production and control of T-cell function. \nSimilarly, platelets are able to activate the endothelium, make it more permeable, and mediate leukocyte trafficking to the inflamed endothelium. \n\nDescription is adapted from Koupenova et al.\n" ;
        dcterms:identifier      "WP4462" ;
        dcterms:references      <https://identifiers.org/pubmed/29348254> ;
        cito:cites              <https://identifiers.org/pubmed/29348254> ;
        wp:cellTypeOntologyTag  obo:CL_0000233 , obo:CL_0000738 , obo:CL_0000775 , obo:CL_0000084 , obo:CL_0000145 , obo:CL_0000771 , obo:CL_0000576 , obo:CL_0000115 , obo:CL_0000451 , obo:CL_0000623 , obo:CL_0000236 ;
        wp:diseaseOntologyTag   obo:DOID_0060903 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP4462_r139061> ;
        wp:ontologyTag          obo:CL_0000451 , obo:CL_0000738 , obo:CL_0000084 , obo:CL_0000775 , obo:DOID_0060903 , obo:CL_0000115 , obo:CL_0000236 , obo:CL_0000233 , obo:CL_0000771 , wp:Curation:AnalysisCollection , obo:CL_0000145 , obo:CL_0000623 , wp:Curation:ExRNA , obo:CL_0000576 , obo:PW_0000475 ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000475 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4462&oldid=139061> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4462&oldid=139061> ;
        foaf:page               <http://www.wikipathways.org/instance/WP4462_r139061> .

<https://identifiers.org/ensembl/ENSG00000162692>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "VCAM1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000162692> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000162692" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000162692> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7412> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/VCAM1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PDD2> , <https://identifiers.org/uniprot/P19320> , <https://identifiers.org/uniprot/A0A3B3ISS8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14901827> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/bc301> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A3B3ISS8> , <http://purl.uniprot.org/uniprot/P19320> , <http://purl.uniprot.org/uniprot/E9PDD2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000162692> .

<https://identifiers.org/pmc/PMC7665362>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC7665362" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4462> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC7665362> .

<http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/da1ab_1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4462_r139061/Interaction/da1ab> ;
        wp:participants   <https://identifiers.org/uniprot/P16109> , <https://identifiers.org/uniprot/Q14242> ;
        wp:source         <https://identifiers.org/uniprot/Q14242> ;
        wp:target         <https://identifiers.org/uniprot/P16109> .

<https://identifiers.org/ensembl/ENSG00000105329>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TGFB1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105329> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105329" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105329> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7040> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V5Z9> , <https://identifiers.org/uniprot/A0A7I2YQL8> , <https://identifiers.org/uniprot/A0A499FJK2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14904613> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/d9587> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A499FJK2> , <http://purl.uniprot.org/uniprot/A0A7I2YQL8> , <http://purl.uniprot.org/uniprot/A0A7I2V5Z9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105329> .

<https://identifiers.org/ensembl/ENSG00000090339>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ICAM1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000090339> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000090339" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000090339> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3383> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ICAM1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P05362> , <https://identifiers.org/uniprot/E7ESS4> , <https://identifiers.org/uniprot/A0A384MEK5> , <https://identifiers.org/uniprot/K7EKL8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14891079> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/b1d0f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A384MEK5> , <http://purl.uniprot.org/uniprot/E7ESS4> , <http://purl.uniprot.org/uniprot/P05362> , <http://purl.uniprot.org/uniprot/K7EKL8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000090339> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/ensembl/ENSG00000101017>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CD40" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000101017> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000101017" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/ida683a118_2> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/WP/Interaction/ida683a118_1> , <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000101017> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/958> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD40> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P25942> , <https://identifiers.org/uniprot/A0A0S2Z3C7> , <https://identifiers.org/uniprot/H0YE23> , <https://identifiers.org/uniprot/A0A087X1D0> , <https://identifiers.org/uniprot/A0A8Q3WKP3> , <https://identifiers.org/uniprot/A0A8Q3WKP7> , <https://identifiers.org/uniprot/A0A8Q3SI60> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17859635> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/f4649> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087X1D0> , <http://purl.uniprot.org/uniprot/A0A8Q3WKP3> , <http://purl.uniprot.org/uniprot/A0A8Q3WKP7> , <http://purl.uniprot.org/uniprot/H0YE23> , <http://purl.uniprot.org/uniprot/P25942> , <http://purl.uniprot.org/uniprot/A0A0S2Z3C7> , <http://purl.uniprot.org/uniprot/A0A8Q3SI60> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000101017> .

<https://identifiers.org/ensembl/ENSG00000271503>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CCL5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000271503> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000271503" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000271503> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6352> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CCL5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D0EI67> , <https://identifiers.org/uniprot/A0A494C1Q1> , <https://identifiers.org/uniprot/P13501> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/a7ea3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D0EI67> , <http://purl.uniprot.org/uniprot/A0A494C1Q1> , <http://purl.uniprot.org/uniprot/P13501> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000271503> .

<https://identifiers.org/ensembl/ENSG00000119699>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TGFB3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000119699> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000119699" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000119699> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7043> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFB3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P10600> , <https://identifiers.org/uniprot/A0A6Q8PGK5> , <https://identifiers.org/uniprot/A5YM40> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031970> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/de71a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A6Q8PGK5> , <http://purl.uniprot.org/uniprot/A5YM40> , <http://purl.uniprot.org/uniprot/P10600> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000119699> .

<https://identifiers.org/ensembl/ENSG00000125538>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "IL1B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000125538> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000125538" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3553> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IL1B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JVK0> , <https://identifiers.org/uniprot/C9JWV2> , <https://identifiers.org/uniprot/C9JSC2> , <https://identifiers.org/uniprot/P01584> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14916410> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/d0c31> , <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/fb596> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9JSC2> , <http://purl.uniprot.org/uniprot/C9JVK0> , <http://purl.uniprot.org/uniprot/C9JWV2> , <http://purl.uniprot.org/uniprot/P01584> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000125538> .

<https://identifiers.org/ensembl/ENSG00000092969>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TGFB2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000092969> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000092969" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000092969> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7042> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TGFB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P61812> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14908050> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/a0454> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P61812> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000092969> .

<https://identifiers.org/ensembl/ENSG00000108691>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CCL2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000108691> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000108691" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4462_r139061> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000108691> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6347> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CCL2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3KRT7> , <https://identifiers.org/uniprot/P13500> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14885645> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4462_r139061/DataNode/aafdd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P13500> , <http://purl.uniprot.org/uniprot/J3KRT7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000108691> .
