@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/a4271>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/a4271> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000105835> , <https://identifiers.org/ensembl/ENSG00000118689> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000118689> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000105835> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP3630&oldid=138896>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/ensembl/ENSG00000108064>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "TFAM" , "TORC2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000108064> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000108064" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3630_r138896> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/idd9b01f7> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000108064> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7019> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TFAM> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E5KSU5> , <https://identifiers.org/uniprot/H7BYN3> , <https://identifiers.org/uniprot/Q00059> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18031951> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/abfa0> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/c0597> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/fa463> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E5KSU5> , <http://purl.uniprot.org/uniprot/Q00059> , <http://purl.uniprot.org/uniprot/H7BYN3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000108064> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/ide61fe032>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/ide61fe032> .

<https://identifiers.org/ensembl/ENSG00000118689>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "FOXO3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000118689> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000118689" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3630_r138896> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/a4271> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118689> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2309> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FOXO3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A856PRE8> , <https://identifiers.org/uniprot/O43524> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17928794> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/d3b0f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O43524> , <http://purl.uniprot.org/uniprot/A0A856PRE8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000118689> .

<https://identifiers.org/pubmed/19470756>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "19470756" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/iddb37003a> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/19470756> .

<https://identifiers.org/ensembl/ENSG00000143799>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PARP1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000143799> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000143799" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/id1549585d> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/iddb37003a> , <https://identifiers.org/wikipathways/WP3630_r138896> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/e2982> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000143799> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/142> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PARP1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V625> , <https://identifiers.org/uniprot/A0A024R3T8> , <https://identifiers.org/uniprot/A0A7I2V5E9> , <https://identifiers.org/uniprot/P09874> , <https://identifiers.org/uniprot/A0A7I2V384> , <https://identifiers.org/uniprot/A0A7I2V3E1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17710375> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/a1e1d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2V3E1> , <http://purl.uniprot.org/uniprot/P09874> , <http://purl.uniprot.org/uniprot/A0A7I2V5E9> , <http://purl.uniprot.org/uniprot/A0A024R3T8> , <http://purl.uniprot.org/uniprot/A0A7I2V625> , <http://purl.uniprot.org/uniprot/A0A7I2V384> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000143799> .

<https://identifiers.org/ensembl/ENSG00000142082>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "SIRT3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000142082> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000142082" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/idd9b01f7> , <https://identifiers.org/wikipathways/WP3630_r138896> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/ae3ab> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000142082> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/23410> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SIRT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PM75> , <https://identifiers.org/uniprot/E9PJS6> , <https://identifiers.org/uniprot/B7WNN4> , <https://identifiers.org/uniprot/E9PK80> , <https://identifiers.org/uniprot/E9PIT6> , <https://identifiers.org/uniprot/E9PM52> , <https://identifiers.org/uniprot/Q9NTG7> , <https://identifiers.org/uniprot/E9PR48> , <https://identifiers.org/uniprot/E9PN58> , <https://identifiers.org/uniprot/E9PNA0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18037158> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/bdb6e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9NTG7> , <http://purl.uniprot.org/uniprot/B7WNN4> , <http://purl.uniprot.org/uniprot/E9PR48> , <http://purl.uniprot.org/uniprot/E9PM75> , <http://purl.uniprot.org/uniprot/E9PN58> , <http://purl.uniprot.org/uniprot/E9PK80> , <http://purl.uniprot.org/uniprot/E9PIT6> , <http://purl.uniprot.org/uniprot/E9PJS6> , <http://purl.uniprot.org/uniprot/E9PM52> , <http://purl.uniprot.org/uniprot/E9PNA0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000142082> .

<https://identifiers.org/ensembl/ENSG00000105835>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "NAMPT" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105835> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105835" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/a4271> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/id68473c22> , <https://identifiers.org/wikipathways/WP3630_r138896> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/idba629f1a> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105835> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10135> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NAMPT> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7P0T8Z3> , <https://identifiers.org/uniprot/A0A0C4DFS8> , <https://identifiers.org/uniprot/A0A7P0T8D2> , <https://identifiers.org/uniprot/A0A7P0Z466> , <https://identifiers.org/uniprot/A0A7P0TBB7> , <https://identifiers.org/uniprot/A0A7P0TAZ2> , <https://identifiers.org/uniprot/A0A7P0TAI8> , <https://identifiers.org/uniprot/A0A7P0TAS5> , <https://identifiers.org/uniprot/A0A7P0T862> , <https://identifiers.org/uniprot/A0A024R718> , <https://identifiers.org/uniprot/A0A7P0TA73> , <https://identifiers.org/uniprot/A0A7P0T9F0> , <https://identifiers.org/uniprot/A0A7P0Z4L4> , <https://identifiers.org/uniprot/B7Z8W6> , <https://identifiers.org/uniprot/A0A7P0TB17> , <https://identifiers.org/uniprot/A0A7P0T973> , <https://identifiers.org/uniprot/A0A7P0Z437> , <https://identifiers.org/uniprot/A0A7P0T931> , <https://identifiers.org/uniprot/A0A7P0T941> , <https://identifiers.org/uniprot/C9JG65> , <https://identifiers.org/uniprot/A0A7P0T895> , <https://identifiers.org/uniprot/A0A7P0T8L3> , <https://identifiers.org/uniprot/A0A7P0Z4N0> , <https://identifiers.org/uniprot/A0A7P0T8R4> , <https://identifiers.org/uniprot/P43490> , <https://identifiers.org/uniprot/C9JF35> , <https://identifiers.org/uniprot/A0A7P0T9I9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18035058> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/b74eb> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0TAZ2> , <http://purl.uniprot.org/uniprot/P43490> , <http://purl.uniprot.org/uniprot/A0A7P0T8Z3> , <http://purl.uniprot.org/uniprot/A0A7P0Z4L4> , <http://purl.uniprot.org/uniprot/A0A7P0TB17> , <http://purl.uniprot.org/uniprot/A0A7P0TAI8> , <http://purl.uniprot.org/uniprot/A0A7P0TA73> , <http://purl.uniprot.org/uniprot/C9JF35> , <http://purl.uniprot.org/uniprot/A0A7P0Z4N0> , <http://purl.uniprot.org/uniprot/A0A7P0TBB7> , <http://purl.uniprot.org/uniprot/A0A7P0T8L3> , <http://purl.uniprot.org/uniprot/A0A7P0T931> , <http://purl.uniprot.org/uniprot/A0A7P0Z437> , <http://purl.uniprot.org/uniprot/A0A7P0TAS5> , <http://purl.uniprot.org/uniprot/A0A7P0T8D2> , <http://purl.uniprot.org/uniprot/A0A7P0T8R4> , <http://purl.uniprot.org/uniprot/A0A7P0T9I9> , <http://purl.uniprot.org/uniprot/A0A7P0T941> , <http://purl.uniprot.org/uniprot/A0A7P0T973> , <http://purl.uniprot.org/uniprot/A0A024R718> , <http://purl.uniprot.org/uniprot/A0A7P0T9F0> , <http://purl.uniprot.org/uniprot/A0A7P0T895> , <http://purl.uniprot.org/uniprot/B7Z8W6> , <http://purl.uniprot.org/uniprot/A0A0C4DFS8> , <http://purl.uniprot.org/uniprot/A0A7P0Z466> , <http://purl.uniprot.org/uniprot/C9JG65> , <http://purl.uniprot.org/uniprot/A0A7P0T862> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105835> .

<https://identifiers.org/pubmed/16628003>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "16628003" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/iddb37003a> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/16628003> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/idba629f1a>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/idba629f1a> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000105835> , <https://identifiers.org/ensembl/ENSG00000150907> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000150907> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000105835> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/idedd953c8>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/idedd953c8> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0000902> , <https://identifiers.org/hmdb/HMDB0000855> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0000855> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0000902> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/id3c940720>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/id3c940720> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000096717> , <https://identifiers.org/hmdb/HMDB0000902> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0000902> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000096717> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/id647ea175>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/id647ea175> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000109320> , <https://identifiers.org/ensembl/ENSG00000096717> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000096717> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000109320> .

<https://identifiers.org/ensembl/ENSG00000109320>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "NFKB1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000109320> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000109320" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP3630_r138896> , <http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/id647ea175> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000109320> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4790> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFKB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TLB2> , <https://identifiers.org/uniprot/D6RC45> , <https://identifiers.org/uniprot/A0A494C157> , <https://identifiers.org/uniprot/P19838> , <https://identifiers.org/uniprot/D6RH30> , <https://identifiers.org/uniprot/A0A494C1E9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15317427> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP3630_r138896/DataNode/b1532> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A494C1E9> , <http://purl.uniprot.org/uniprot/A0A494C157> , <http://purl.uniprot.org/uniprot/D6RC45> , <http://purl.uniprot.org/uniprot/A0A8V8TLB2> , <http://purl.uniprot.org/uniprot/P19838> , <http://purl.uniprot.org/uniprot/D6RH30> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000109320> .

<https://identifiers.org/wikipathways/WP3630>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP3630_r138896> .

<https://identifiers.org/pmc/PMC12301734>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC12301734" ;
        cito:cites          <https://identifiers.org/wikipathways/WP3630> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC12301734> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/idd9b01f7>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/idd9b01f7> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000108064> , <https://identifiers.org/ensembl/ENSG00000142082> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000142082> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000108064> .

<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/e2982>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP3630_r138896> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP3630_r138896/Interaction/e2982> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000143799> , <https://identifiers.org/chebi/CHEBI:83766> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:83766> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000143799> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/hmdb/HMDB0000902>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "NAD" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BAWFJGJZGIEFAR-NNYOXOHSSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000902> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000902" ;
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        foaf:page           <https://commonchemistry.cas.org/detail?cas_rn=501-36-0> .

<https://identifiers.org/ensembl/ENSG00000150907>
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<https://identifiers.org/hmdb/HMDB0000855>
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<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/ide7a6c22>
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<https://identifiers.org/ensembl/ENSG00000096717>
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<https://identifiers.org/pubmed/26785480>
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        dc:source              "WikiPathways" ;
        dc:title               "NAD metabolism, sirtuins and aging"@en ;
        dcterms:description    "A model for DNA damage, inflammation, NAD+, and aging.\nTwo key events, the activation of PARP by DNA damage and the decreased NAMPT expression associated with inflammation, lead to decreased SIRT1 and SIRT3 activity in the nucleus and mitochondria, respectively. Decreased SIRT1 activity is associated with further PARP activation and increased DNA damage. Decreased SIRT1 also leads to NF-kB activation and decreased FOXO3a activity, two factors that lead to increased inflammation. These contribute to the establishment of two parallel feed-forward self reinforcing loops that further accelerate the aging process. This process is initiated earlier and faster in patients with DNA damage repair defects (such as CS, XPA, and AT). Mitochondrial function is diminished as a result of decreased SIRT3 activity, leading to mitochondrial protein hyperacetylation, whereas decreased SIRT1 is associated with decreased TFAM (necessary for mitochondrial DNA replication and transcription) and decreased PGC-1a (necessary for mitochondrial biogenesis). Possible therapeutic interventions to restore NAD+ levels are illustrated for each of the key enzymes (red arrows). Based on fig 4 from [Verdin](http://science.sciencemag.org/content/350/6265/1208.long).\n\nProteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3630)." ;
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<http://rdf.wikipathways.org/Pathway/WP3630_r138896/WP/Interaction/id68473c22>
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        rdf:type        foaf:Image ;
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<https://identifiers.org/chebi/CHEBI:83766>
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<https://identifiers.org/pmc/PMC9293528>
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<https://identifiers.org/ensembl/ENSG00000132170>
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        rdfs:label          "PPARG" ;
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        foaf:page           <https://www.ensembl.org/id/ENSG00000132170> .
