@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/pubmed/29438108>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "29438108" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5428_r141656> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/29438108> .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id2196a4aa>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Interaction/id2196a4aa> ;
        wp:participants   <https://identifiers.org/uniprot/P40763> .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id7e4af476>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Interaction/id7e4af476> ;
        wp:participants   <https://identifiers.org/uniprot/P22301> .

<https://identifiers.org/pubmed/26675719>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "26675719" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/P22455> , <https://identifiers.org/wikipathways/WP5428_r141656> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/26675719> .

<https://identifiers.org/wikipathways/WP5428_r141656>
        rdf:type                skos:Collection , wp:Pathway ;
        dc:identifier           <https://identifiers.org/wikipathways/WP5428> ;
        dc:source               "WikiPathways" ;
        dc:title                "FGFR4 p.G388R signaling"@en ;
        dcterms:description     "A germline variant, rs351855-G/A, in FGFR (c.1162G>A, p.Gly388Arg), activates the proximal STAT3 signaling pathway. This germline receptor variant, FGFR p.Gly388Arg, recruits STAT3 to inner cell membranes, resulting in increased levels of STAT3 tyrosine phosphorylation. This heritable variant-specific signaling pathway enhances both tumor-intrinsic proliferation and tumor-extrinsic immune evasion within the tumor microenvironment.\nThe tumor-intrinsic molecular function is driven by elevated levels of tyrosine-phosphorylated STAT3 in tumor cells, promoting cell division and enhancing proliferation. Meanwhile, the tumor-extrinsic molecular function is influenced by increased levels of tyrosine-phosphorylated STAT3 in regulatory T cells and CD8 T cells. This activates the STAT3 signaling pathway predominantly in Tregs and alters the Treg/CD8 T cell ratio in lymphoid organs, thereby limiting immune surveillance within the tumor microenvironment." ;
        dcterms:identifier      "WP5428" ;
        dcterms:references      <https://identifiers.org/pubmed/27314095> , <https://identifiers.org/pubmed/26675719> , <https://identifiers.org/pubmed/29438108> ;
        cito:cites              <https://identifiers.org/pubmed/26675719> , <https://identifiers.org/pubmed/11244051> , <https://identifiers.org/pubmed/17186030> , <https://identifiers.org/pubmed/29438108> , <https://identifiers.org/pubmed/27314095> ;
        wp:cellTypeOntologyTag  obo:CL_0000815 , obo:CL_0001064 , obo:CL_0001050 , obo:CL_0001063 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP5428_r141656> ;
        wp:ontologyTag          obo:PW_0000328 , obo:CL_0001064 , obo:CL_0001050 , obo:CL_0000815 , obo:PW_0000605 , obo:CL_0001063 , wp:Curation:AnalysisCollection ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000605 , obo:PW_0000328 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5428&oldid=141656> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5428&oldid=141656> ;
        foaf:page               <http://www.wikipathways.org/instance/WP5428_r141656> .

<https://identifiers.org/pubmed/17186030>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "17186030" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/P40763> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17186030> .

<https://identifiers.org/pubmed/27314095>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "27314095" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5428_r141656> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/27314095> .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id3fe4d585>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Interaction/id3fe4d585> ;
        wp:participants   <https://identifiers.org/uniprot/P40763> .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/d8594>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Interaction/d8594> ;
        wp:participants   <https://identifiers.org/uniprot/P40763> .

<https://identifiers.org/uniprot/P40763>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "STAT3" ;
        dc:identifier       <https://identifiers.org/uniprot/P40763> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P40763" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/d8594> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id2196a4aa> , <https://identifiers.org/wikipathways/WP5428_r141656> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/e69af> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Complex/c6ad9> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id3fe4d585> ;
        dcterms:references  <https://identifiers.org/pubmed/17186030> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000168610> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6774> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/STAT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7I2V3V0> , <https://identifiers.org/uniprot/A0A7I2V4R2> , <https://identifiers.org/uniprot/A0A7I2V552> , <https://identifiers.org/uniprot/A0A7I2YQD2> , <https://identifiers.org/uniprot/A0A7I2V444> , <https://identifiers.org/uniprot/A0A7I2V4R3> , <https://identifiers.org/uniprot/A0A7I2V4F6> , <https://identifiers.org/uniprot/A0A7I2V5N9> , <https://identifiers.org/uniprot/A0A7I2V395> , <https://identifiers.org/uniprot/G8JLH9> , <https://identifiers.org/uniprot/A0A7I2V2G1> , <https://identifiers.org/uniprot/A0A7I2V2T1> , <https://identifiers.org/uniprot/P40763> , <https://identifiers.org/uniprot/A0A7I2V4C8> , <https://identifiers.org/uniprot/A0A7I2YQR5> , <https://identifiers.org/uniprot/A0A7I2YQI1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/c8326> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/a73f6> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/ee0eb> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/ed5bf> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/c73af> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/a0784> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/d68d9> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/c2008> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G8JLH9> , <http://purl.uniprot.org/uniprot/A0A7I2V5N9> , <http://purl.uniprot.org/uniprot/A0A7I2V395> , <http://purl.uniprot.org/uniprot/A0A7I2V444> , <http://purl.uniprot.org/uniprot/A0A7I2V4R2> , <http://purl.uniprot.org/uniprot/A0A7I2V4F6> , <http://purl.uniprot.org/uniprot/A0A7I2V552> , <http://purl.uniprot.org/uniprot/A0A7I2YQR5> , <http://purl.uniprot.org/uniprot/A0A7I2V3V0> , <http://purl.uniprot.org/uniprot/A0A7I2YQI1> , <http://purl.uniprot.org/uniprot/P40763> , <http://purl.uniprot.org/uniprot/A0A7I2V2T1> , <http://purl.uniprot.org/uniprot/A0A7I2YQD2> , <http://purl.uniprot.org/uniprot/A0A7I2V4C8> , <http://purl.uniprot.org/uniprot/A0A7I2V4R3> , <http://purl.uniprot.org/uniprot/A0A7I2V2G1> ;
        foaf:page           <http://www.uniprot.org/uniprot/P40763> .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id103ac82b>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Interaction/id103ac82b> ;
        wp:participants   <https://identifiers.org/wikipathways/WP179> , <https://identifiers.org/uniprot/P22301> ;
        wp:source         <https://identifiers.org/uniprot/P22301> ;
        wp:target         <https://identifiers.org/wikipathways/WP179> .

<https://identifiers.org/uniprot/P22455>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "CD334" ;
        dc:identifier       <https://identifiers.org/uniprot/P22455> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P22455" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5428_r141656> ;
        dcterms:references  <https://identifiers.org/pubmed/26675719> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000160867> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2264> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/FGFR4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B5A964> , <https://identifiers.org/uniprot/E7EWF4> , <https://identifiers.org/uniprot/P22455> , <https://identifiers.org/uniprot/D6RG06> , <https://identifiers.org/uniprot/D6R9V0> , <https://identifiers.org/uniprot/D6RJD4> , <https://identifiers.org/uniprot/H0Y9P2> , <https://identifiers.org/uniprot/J3KPQ0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/dc77e> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/f4b1f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H0Y9P2> , <http://purl.uniprot.org/uniprot/P22455> , <http://purl.uniprot.org/uniprot/J3KPQ0> , <http://purl.uniprot.org/uniprot/B5A964> , <http://purl.uniprot.org/uniprot/E7EWF4> , <http://purl.uniprot.org/uniprot/D6R9V0> , <http://purl.uniprot.org/uniprot/D6RJD4> , <http://purl.uniprot.org/uniprot/D6RG06> ;
        foaf:page           <http://www.uniprot.org/uniprot/P22455> .

<https://doi.org/10.1146%2FANNUREV.IMMUNOL.19.1.683>
        dc:source           "DOI" ;
        dcterms:identifier  "10.1146/ANNUREV.IMMUNOL.19.1.683" .

<https://identifiers.org/wikipathways/WP5428>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP5428_r141656> .

<https://identifiers.org/ensembl/ENSG00000136634>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "IL10" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000136634> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000136634" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136634> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3586> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IL10> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P22301> , <https://identifiers.org/uniprot/A0A286YEX3> , <https://identifiers.org/uniprot/Q6FGW4> , <https://identifiers.org/uniprot/A0A590UK12> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14864464> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/dda73> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q6FGW4> , <http://purl.uniprot.org/uniprot/A0A590UK12> , <http://purl.uniprot.org/uniprot/A0A286YEX3> , <http://purl.uniprot.org/uniprot/P22301> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000136634> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5428&oldid=141656>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/e69af>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Interaction/e69af> ;
        wp:participants   <https://identifiers.org/uniprot/P40763> .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/Complex/c6ad9>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Group/c6ad9> ;
        wp:participants   <https://identifiers.org/uniprot/P40763> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<https://identifiers.org/pubmed/11244051>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "11244051" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/P22301> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q24290912> ;
        owl:sameAs          <https://doi.org/10.1146%2FANNUREV.IMMUNOL.19.1.683> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/11244051> .

<https://identifiers.org/uniprot/P22301>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "IL10" ;
        dc:identifier       <https://identifiers.org/uniprot/P22301> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P22301" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id103ac82b> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id7e4af476> , <https://identifiers.org/wikipathways/WP5428_r141656> ;
        dcterms:references  <https://identifiers.org/pubmed/11244051> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000136634> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3586> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IL10> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A590UK12> , <https://identifiers.org/uniprot/P22301> , <https://identifiers.org/uniprot/Q6FGW4> , <https://identifiers.org/uniprot/A0A286YEX3> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/c0bb9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A590UK12> , <http://purl.uniprot.org/uniprot/Q6FGW4> , <http://purl.uniprot.org/uniprot/P22301> , <http://purl.uniprot.org/uniprot/A0A286YEX3> ;
        foaf:page           <http://www.uniprot.org/uniprot/P22301> .

<https://identifiers.org/wikipathways/WP179>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "Cell cycle progression" , "Proliferation" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP179> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP179" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5428_r141656/WP/Interaction/id103ac82b> , <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/bd269> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/d30f9> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/DataNode/c15ac> ;
        foaf:page           <https://www.wikipathways.org/instance/WP179> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5428&oldid=141656>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP5428_r141656/ComplexBinding/c6ad9>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5428_r141656> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Group/c6ad9> ;
        wp:participants   <https://identifiers.org/uniprot/P40763> , <http://rdf.wikipathways.org/Pathway/WP5428_r141656/Complex/c6ad9> .
