@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000103490>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ASC" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000103490> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000103490" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/f1f54> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000103490> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/29108> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PYCARD> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BP42> , <https://identifiers.org/uniprot/Q9ULZ3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18039614> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/bbb80> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9ULZ3> , <http://purl.uniprot.org/uniprot/H3BP42> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000103490> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/f1f54>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Group/f1f54> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000137752> , <https://identifiers.org/ensembl/ENSG00000103490> , <https://identifiers.org/ensembl/ENSG00000162711> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/ComplexBinding/d72a0>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Group/d72a0> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000109320> , <https://identifiers.org/ensembl/ENSG00000173039> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/d72a0> .

<https://doi.org/10.1097%2FMD.0000000000033917>
        rdf:type            wp:PublicationReference ;
        dc:source           "DOI" ;
        dcterms:identifier  "10.1097/MD.0000000000033917" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4876> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/idaa5a11ed>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/idaa5a11ed> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000125538> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/d72a0>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Group/d72a0> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000109320> , <https://identifiers.org/ensembl/ENSG00000173039> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4876&oldid=140856>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<https://identifiers.org/wikidata/Q422438>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Chloroquine" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/WHTVZRBIWZFKQO-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/wikidata/Q422438> ;
        dc:source           "Wikidata" ;
        dcterms:identifier  "Q422438" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id37038832> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:3638> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/2618> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0014746> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/WHTVZRBIWZFKQO-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C07625> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID2719> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q422438> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/d8fdf> ;
        foaf:page           <https://scholia.toolforge.org/Q422438> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ide5852d1c>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/ide5852d1c> ;
        wp:participants   <https://identifiers.org/wikipathways/WP5257> , <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:target         <https://identifiers.org/wikipathways/WP5257> .

<https://identifiers.org/ensembl/ENSG00000173039>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RELA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000173039> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000173039" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/d72a0> , <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000173039> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5970> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RELA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PJZ9> , <https://identifiers.org/uniprot/E9PJR1> , <https://identifiers.org/uniprot/Q2TAM5> , <https://identifiers.org/uniprot/E9PRX2> , <https://identifiers.org/uniprot/H0YCB4> , <https://identifiers.org/uniprot/Q04206> , <https://identifiers.org/uniprot/E9PKV4> , <https://identifiers.org/uniprot/E9PKH5> , <https://identifiers.org/uniprot/E9PSE4> , <https://identifiers.org/uniprot/E9PNV4> , <https://identifiers.org/uniprot/E9PNK5> , <https://identifiers.org/uniprot/A0A087X0W8> , <https://identifiers.org/uniprot/E9PMD5> , <https://identifiers.org/uniprot/E9PM47> , <https://identifiers.org/uniprot/E9PI38> , <https://identifiers.org/uniprot/E9PQS6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15326052> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/fe12b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PM47> , <http://purl.uniprot.org/uniprot/E9PNV4> , <http://purl.uniprot.org/uniprot/A0A087X0W8> , <http://purl.uniprot.org/uniprot/E9PI38> , <http://purl.uniprot.org/uniprot/E9PNK5> , <http://purl.uniprot.org/uniprot/E9PJZ9> , <http://purl.uniprot.org/uniprot/E9PKH5> , <http://purl.uniprot.org/uniprot/E9PKV4> , <http://purl.uniprot.org/uniprot/H0YCB4> , <http://purl.uniprot.org/uniprot/E9PMD5> , <http://purl.uniprot.org/uniprot/E9PQS6> , <http://purl.uniprot.org/uniprot/E9PRX2> , <http://purl.uniprot.org/uniprot/Q2TAM5> , <http://purl.uniprot.org/uniprot/Q04206> , <http://purl.uniprot.org/uniprot/E9PJR1> , <http://purl.uniprot.org/uniprot/E9PSE4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000173039> .

<https://identifiers.org/wikipathways/WP4876>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP4876_r140856> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id3a35678b> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/idad3dc034> , <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Group/b6589> ;
        wp:participants   <https://identifiers.org/refseq/YP_009724391> , <https://identifiers.org/ensembl/ENSG00000131323> .

<https://identifiers.org/wikipathways/WP4876_r140856>
        rdf:type               wp:Pathway , skos:Collection ;
        dc:identifier          <https://identifiers.org/wikipathways/WP4876> ;
        dc:source              "WikiPathways" ;
        dc:title               "Activation of NLRP3 inflammasome by SARS-CoV-2"@en ;
        dcterms:description    "Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome. The activation occurs at two points. First, by ubiquinating NF-kB (p105) to stimulate its proteolytic processing into mature NF-kB (p50), which can then go on to promote the transcription of pro-IL-1B together with RELA (p65). And second, by ubiquitinating ASC (PYCARD) in the NLRP3 inflammasome, which leads to its degradtion and the activation of caspase-1 (CASP1) that goes on to catalyze the production of mature IL-1B, leading to a cytokine storm. While Orf3a of SARS-CoV-2 only has 72.7% sequence identity with that of SARS-CoV, the TRAF3 binding motif PxQxS is 100% conserved (https://alexanderpico.github.io/SARS-CoV-2_Alignments/#Orf3a). Chloroquine, a multi-functional antiviral, decreases the production of IL-1B by affecting \"the processing of primary transcripts in the nucleus, the transport of processed mRNA to the cytosol, and the degradation of mRNA.\" (Jang 2006)" ;
        dcterms:identifier     "WP4876" ;
        dcterms:references     <https://identifiers.org/pubmed/31034780> ;
        cito:cites             <https://identifiers.org/pubmed/31034780> ;
        wp:diseaseOntologyTag  obo:DOID_2945 , obo:DOID_934 , obo:DOID_0080600 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP4876_r140856> ;
        wp:ontologyTag         obo:DOID_2945 , obo:DOID_0080600 , obo:DOID_934 , obo:PW_0000883 , obo:PW_0000004 , wp:Curation:COVID19 , wp:Curation:AnalysisCollection ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000883 , obo:PW_0000004 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP4876&oldid=140856> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4876&oldid=140856> ;
        foaf:page              <http://www.wikipathways.org/instance/WP4876_r140856> .

<https://identifiers.org/pmc/PMC9154116>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed Central" ;
        dcterms:identifier  "PMC9154116" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4876> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/PMC9154116> .

<https://identifiers.org/ensembl/ENSG00000137752>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CASP1" , "pro-CASP1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000137752> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000137752" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id38c72c84> , <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/f1f54> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id7ef1c6cf> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137752> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/834> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CASP1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YEC7> , <https://identifiers.org/uniprot/A0A8Q3SI00> , <https://identifiers.org/uniprot/A0A8Q3SIY2> , <https://identifiers.org/uniprot/G3V169> , <https://identifiers.org/uniprot/P29466> , <https://identifiers.org/uniprot/B4DVD8> , <https://identifiers.org/uniprot/Q5FBZ0> , <https://identifiers.org/uniprot/A0A8Q3SI67> , <https://identifiers.org/uniprot/B4DKN4> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14901964> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/a2318> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/b43c2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5FBZ0> , <http://purl.uniprot.org/uniprot/B4DKN4> , <http://purl.uniprot.org/uniprot/G3V169> , <http://purl.uniprot.org/uniprot/A0A8Q3SI00> , <http://purl.uniprot.org/uniprot/H0YEC7> , <http://purl.uniprot.org/uniprot/B4DVD8> , <http://purl.uniprot.org/uniprot/P29466> , <http://purl.uniprot.org/uniprot/A0A8Q3SIY2> , <http://purl.uniprot.org/uniprot/A0A8Q3SI67> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000137752> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP4876&oldid=140856>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id3a35678b>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/id3a35678b> ;
        wp:participants   <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id7ef1c6cf> ;
        wp:source         <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id7ef1c6cf> .

<https://doi.org/10.1159%2F000529687>
        rdf:type            wp:PublicationReference ;
        dc:source           "DOI" ;
        dcterms:identifier  "10.1159/000529687" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4876> .

<https://doi.org/10.1016%2Fj.humgen.2022.201135>
        rdf:type            wp:PublicationReference ;
        dc:source           "DOI" ;
        dcterms:identifier  "10.1016/j.humgen.2022.201135" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4876> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ed3f9>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/ed3f9> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000125538> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id7ef1c6cf>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/id7ef1c6cf> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000137752> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000137752> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000137752> .

<https://identifiers.org/ensembl/ENSG00000162711>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NLRP3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000162711> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000162711" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/f1f54> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000162711> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/114548> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NLRP3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A2R8YEG7> , <https://identifiers.org/uniprot/A0A7I2PMC6> , <https://identifiers.org/uniprot/A0A7I2R3P8> , <https://identifiers.org/uniprot/A0A7I2UNQ2> , <https://identifiers.org/uniprot/A0A7I2PRX0> , <https://identifiers.org/uniprot/A0A7I2YME5> , <https://identifiers.org/uniprot/A0A7I2PJH0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905618> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/e1fdf> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7I2PRX0> , <http://purl.uniprot.org/uniprot/A0A7I2UNQ2> , <http://purl.uniprot.org/uniprot/A0A2R8YEG7> , <http://purl.uniprot.org/uniprot/A0A7I2PMC6> , <http://purl.uniprot.org/uniprot/A0A7I2R3P8> , <http://purl.uniprot.org/uniprot/A0A7I2YME5> , <http://purl.uniprot.org/uniprot/A0A7I2PJH0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000162711> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id38c72c84>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/id38c72c84> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000137752> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ed3f9> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000137752> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ed3f9> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/ComplexBinding/b6589>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Group/b6589> ;
        wp:participants   <https://identifiers.org/refseq/YP_009724391> , <https://identifiers.org/ensembl/ENSG00000131323> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> .

<https://doi.org/10.3389%2Ffcimb.2022.888582>
        rdf:type            wp:PublicationReference ;
        dc:source           "DOI" ;
        dcterms:identifier  "10.3389/fcimb.2022.888582" ;
        cito:cites          <https://identifiers.org/wikipathways/WP4876> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/idad3dc034>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/idad3dc034> ;
        wp:participants   <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id56c2671f> ;
        wp:source         <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id56c2671f> .

<https://identifiers.org/refseq/YP_009724391>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "orf3a" ;
        dc:identifier       <https://identifiers.org/refseq/YP_009724391> ;
        dc:source           "RefSeq" ;
        dcterms:identifier  "YP_009724391" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/dc9ef> ;
        foaf:page           <https://www.ncbi.nlm.nih.gov/protein/YP_009724391> .

<https://identifiers.org/wikipathways/WP5257>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "Cytokine storm" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP5257> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP5257" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ide5852d1c> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/dd226> ;
        foaf:page           <https://www.wikipathways.org/instance/WP5257> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id56c2671f>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/id56c2671f> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000109320> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000109320> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000109320> .

<https://identifiers.org/pubmed/31034780>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "31034780" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/31034780> .

<https://identifiers.org/ensembl/ENSG00000109320>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "NFKB1" , "NFKB1 p105" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000109320> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000109320" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/d72a0> , <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id56c2671f> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000109320> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4790> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NFKB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TLB2> , <https://identifiers.org/uniprot/D6RC45> , <https://identifiers.org/uniprot/A0A494C157> , <https://identifiers.org/uniprot/P19838> , <https://identifiers.org/uniprot/D6RH30> , <https://identifiers.org/uniprot/A0A494C1E9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15317427> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/dc151> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/ae8f7> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A494C1E9> , <http://purl.uniprot.org/uniprot/A0A494C157> , <http://purl.uniprot.org/uniprot/D6RC45> , <http://purl.uniprot.org/uniprot/A0A8V8TLB2> , <http://purl.uniprot.org/uniprot/P19838> , <http://purl.uniprot.org/uniprot/D6RH30> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000109320> .

<https://identifiers.org/ensembl/ENSG00000125538>
        rdf:type            wp:DataNode , wp:GeneProduct , wp:Rna ;
        rdfs:label          "pro-IL1B" , "IL1B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000125538> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000125538" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/idaa5a11ed> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id37038832> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ed3f9> , <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/ide5852d1c> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000125538> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3553> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IL1B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JVK0> , <https://identifiers.org/uniprot/C9JWV2> , <https://identifiers.org/uniprot/C9JSC2> , <https://identifiers.org/uniprot/P01584> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14916410> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/b860a> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/d3559> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/a1e57> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9JSC2> , <http://purl.uniprot.org/uniprot/C9JVK0> , <http://purl.uniprot.org/uniprot/C9JWV2> , <http://purl.uniprot.org/uniprot/P01584> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000125538> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/WP/Interaction/id37038832>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Interaction/id37038832> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000125538> , <https://identifiers.org/wikidata/Q422438> ;
        wp:source         <https://identifiers.org/wikidata/Q422438> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000125538> .

<https://identifiers.org/ensembl/ENSG00000131323>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "TRAF3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000131323> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000131323" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP4876_r140856> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/b6589> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000131323> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7187> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TRAF3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YMI8> , <https://identifiers.org/uniprot/A6NHG8> , <https://identifiers.org/uniprot/H0YL26> , <https://identifiers.org/uniprot/H0YL25> , <https://identifiers.org/uniprot/Q13114> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18032095> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP4876_r140856/DataNode/efb77> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A6NHG8> , <http://purl.uniprot.org/uniprot/H0YL26> , <http://purl.uniprot.org/uniprot/Q13114> , <http://purl.uniprot.org/uniprot/H0YL25> , <http://purl.uniprot.org/uniprot/H0YMI8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000131323> .

<http://rdf.wikipathways.org/Pathway/WP4876_r140856/ComplexBinding/f1f54>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP4876_r140856> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Group/f1f54> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000137752> , <https://identifiers.org/ensembl/ENSG00000103490> , <https://identifiers.org/ensembl/ENSG00000162711> , <http://rdf.wikipathways.org/Pathway/WP4876_r140856/Complex/f1f54> .
