@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/chebi/CHEBI:15756>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Palmitate" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/IPCSVZSSVZVIGE-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15756> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:15756" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idcbb4b83c> , <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8d212565> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15756> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/960> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000220> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/IPCSVZSSVZVIGE-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00249> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMFA01010001> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135369651> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID985> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q209727> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/d8185> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a82e0> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMFA01010001> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15756> .

<https://identifiers.org/ensembl/ENSG00000107643>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MAPK8" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000107643> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000107643" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000107643> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5599> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK8> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A3B3IRW7> , <https://identifiers.org/uniprot/A1L4K2> , <https://identifiers.org/uniprot/C9JWQ4> , <https://identifiers.org/uniprot/P45983> , <https://identifiers.org/uniprot/C9J762> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18255755> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a1fba> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A1L4K2> , <http://purl.uniprot.org/uniprot/A0A3B3IRW7> , <http://purl.uniprot.org/uniprot/C9JWQ4> , <http://purl.uniprot.org/uniprot/P45983> , <http://purl.uniprot.org/uniprot/C9J762> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000107643> .

<https://identifiers.org/uniprot/P16671>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "CD36/FAT" ;
        dc:identifier       <https://identifiers.org/uniprot/P16671> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P16671" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id273e207> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id7f36fda6> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135218> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/948> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CD36> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YEE7> , <https://identifiers.org/uniprot/E7EVU1> , <https://identifiers.org/uniprot/E9PC45> , <https://identifiers.org/uniprot/E7EWI4> , <https://identifiers.org/uniprot/E9PLT1> , <https://identifiers.org/uniprot/E7EX47> , <https://identifiers.org/uniprot/P16671> , <https://identifiers.org/uniprot/E7ERZ9> , <https://identifiers.org/uniprot/E9PJX8> , <https://identifiers.org/uniprot/E7EU05> , <https://identifiers.org/uniprot/A4D1B1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/b4348> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E7EWI4> , <http://purl.uniprot.org/uniprot/E7EU05> , <http://purl.uniprot.org/uniprot/E7ERZ9> , <http://purl.uniprot.org/uniprot/H0YEE7> , <http://purl.uniprot.org/uniprot/A4D1B1> , <http://purl.uniprot.org/uniprot/E7EX47> , <http://purl.uniprot.org/uniprot/P16671> , <http://purl.uniprot.org/uniprot/E9PJX8> , <http://purl.uniprot.org/uniprot/E9PC45> , <http://purl.uniprot.org/uniprot/E7EVU1> , <http://purl.uniprot.org/uniprot/E9PLT1> ;
        foaf:page           <http://www.uniprot.org/uniprot/P16671> .

<https://identifiers.org/uniprot/Q9UGI9>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "AMPK" ;
        dc:identifier       <https://identifiers.org/uniprot/Q9UGI9> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q9UGI9" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id7eb7eaa6> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id89d104c1> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id199b5058> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/24037260> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115592> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/53632> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKAG3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9UGI9> , <https://identifiers.org/uniprot/B4DUK8> , <https://identifiers.org/uniprot/C9JIC7> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/bc8de> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9UGI9> , <http://purl.uniprot.org/uniprot/B4DUK8> , <http://purl.uniprot.org/uniprot/C9JIC7> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q9UGI9> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1d6e1933>
        rdf:type            wp:DirectedInteraction , wp:Interaction , wp:Stimulation ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33738905> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id1d6e1933> ;
        wp:participants     <https://identifiers.org/ensembl/ENSG00000142208> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id56c45eff> ;
        wp:source           <https://identifiers.org/ensembl/ENSG00000142208> ;
        wp:target           <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id56c45eff> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8475b052>
        rdf:type            wp:DirectedInteraction , wp:Conversion , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33738905> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id8475b052> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:52639> , <https://identifiers.org/chebi/CHEBI:89490> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:89490> ;
        wp:target           <https://identifiers.org/chebi/CHEBI:52639> .

<https://identifiers.org/wikipathways/WP408>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "Oxidative stress response" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP408> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP408" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/iddc5b3e79> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/d40b1> ;
        foaf:page           <https://www.wikipathways.org/instance/WP408> .

<https://identifiers.org/uniprot/P14672>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "GLUT4" ;
        dc:identifier       <https://identifiers.org/uniprot/P14672> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P14672" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id2bff242a> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id56c45eff> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000181856> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6517> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SLC2A4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/I3L2R4> , <https://identifiers.org/uniprot/P14672> , <https://identifiers.org/uniprot/I3L1S2> , <https://identifiers.org/uniprot/F5H081> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/f6fe3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/I3L2R4> , <http://purl.uniprot.org/uniprot/P14672> , <http://purl.uniprot.org/uniprot/F5H081> , <http://purl.uniprot.org/uniprot/I3L1S2> ;
        foaf:page           <http://www.uniprot.org/uniprot/P14672> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idfd9a9ea2>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/idfd9a9ea2> ;
        wp:participants   <https://identifiers.org/wikipathways/WP1422> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idb04bf414> ;
        wp:source         <https://identifiers.org/wikipathways/WP1422> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idb04bf414> .

<https://identifiers.org/uniprot/P52945>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PDX1" ;
        dc:identifier       <https://identifiers.org/uniprot/P52945> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P52945" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/25814122> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000139515> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3651> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PDX1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P52945> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/d3784> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P52945> ;
        foaf:page           <http://www.uniprot.org/uniprot/P52945> .

<https://identifiers.org/pubmed/23329830>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "23329830" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id290e8371> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/23329830> .

<https://identifiers.org/pubmed/19553926>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "19553926" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/Q92523> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/19553926> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5181&oldid=134495>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id290e8371>
        rdf:type            wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/23329830> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id290e8371> ;
        wp:participants     <https://identifiers.org/uniprot/Q92523> , <https://identifiers.org/hmdb/HMDB0000207> ;
        wp:source           <https://identifiers.org/hmdb/HMDB0000207> ;
        wp:target           <https://identifiers.org/uniprot/Q92523> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id21cf08df>
        rdf:type            wp:DirectedInteraction , wp:Stimulation , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33738905> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id21cf08df> ;
        wp:participants     <https://identifiers.org/ensembl/ENSG00000142208> , <https://identifiers.org/uniprot/P27986> ;
        wp:source           <https://identifiers.org/uniprot/P27986> ;
        wp:target           <https://identifiers.org/ensembl/ENSG00000142208> .

<https://identifiers.org/pubmed/4722436>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "4722436" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id91de6a48> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/4722436> .

<https://identifiers.org/chebi/CHEBI:17234>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "glucose" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:17234> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:17234" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id2bff242a> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:17234> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q37525> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/e98a0> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17234> .

<https://identifiers.org/uniprot/Q9NY59>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "nSMase2" ;
        dc:identifier       <https://identifiers.org/uniprot/Q9NY59> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q9NY59" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/ida0702410> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id4caa4577> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33738905> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000103056> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/55512> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/SMPD3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H3BTM0> , <https://identifiers.org/uniprot/H3BS51> , <https://identifiers.org/uniprot/Q9NY59> , <https://identifiers.org/uniprot/I3L228> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/da30b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/I3L228> , <http://purl.uniprot.org/uniprot/H3BS51> , <http://purl.uniprot.org/uniprot/H3BTM0> , <http://purl.uniprot.org/uniprot/Q9NY59> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q9NY59> .

<https://identifiers.org/pubmed/24037260>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "24037260" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/Q9UGI9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/24037260> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8a68d7ee>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id8a68d7ee> ;
        wp:participants   <https://identifiers.org/uniprot/P06213> , <https://identifiers.org/uniprot/P01308> .

<https://identifiers.org/wikipathways/WP143>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "Fatty Acid Oxidation" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP143> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP143" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id5bc1f579> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/f3339> ;
        foaf:page           <https://www.wikipathways.org/instance/WP143> .

<https://identifiers.org/pubmed/33738905>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "33738905" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id989a1f67> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id4caa4577> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1d6e1933> , <https://identifiers.org/uniprot/Q9NY59> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id21cf08df> , <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8475b052> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/33738905> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id7eb7eaa6>
        rdf:type            wp:Interaction , wp:DirectedInteraction , wp:Stimulation ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/29290500> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id7eb7eaa6> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:15525> , <https://identifiers.org/uniprot/Q9UGI9> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:15525> ;
        wp:target           <https://identifiers.org/uniprot/Q9UGI9> .

<https://identifiers.org/uniprot/P35568>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "IRS-1" ;
        dc:identifier       <https://identifiers.org/uniprot/P35568> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P35568" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/20182627> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000169047> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3667> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IRS1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P35568> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/e5f13> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/cb1dc> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P35568> ;
        foaf:page           <http://www.uniprot.org/uniprot/P35568> .

<https://identifiers.org/uniprot/P67775>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "PP2A" ;
        dc:identifier       <https://identifiers.org/uniprot/P67775> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P67775" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000113575> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5515> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PPP2CA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TRB3> , <https://identifiers.org/uniprot/A0A8V8TQU8> , <https://identifiers.org/uniprot/B3KUN1> , <https://identifiers.org/uniprot/B3KQ51> , <https://identifiers.org/uniprot/P67775> , <https://identifiers.org/uniprot/E7ESG8> , <https://identifiers.org/uniprot/A0A8V8TRA6> , <https://identifiers.org/uniprot/A0A8V8TQA1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/b9b0d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TRA6> , <http://purl.uniprot.org/uniprot/A0A8V8TRB3> , <http://purl.uniprot.org/uniprot/E7ESG8> , <http://purl.uniprot.org/uniprot/A0A8V8TQA1> , <http://purl.uniprot.org/uniprot/B3KUN1> , <http://purl.uniprot.org/uniprot/A0A8V8TQU8> , <http://purl.uniprot.org/uniprot/P67775> , <http://purl.uniprot.org/uniprot/B3KQ51> ;
        foaf:page           <http://www.uniprot.org/uniprot/P67775> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/ida0702410>
        rdf:type            wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33033337> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/ida0702410> ;
        wp:participants     <https://identifiers.org/uniprot/Q9NY59> , <https://identifiers.org/uniprot/P19438> ;
        wp:source           <https://identifiers.org/uniprot/P19438> ;
        wp:target           <https://identifiers.org/uniprot/Q9NY59> .

<https://identifiers.org/uniprot/P19438>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "TNFR" ;
        dc:identifier       <https://identifiers.org/uniprot/P19438> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P19438" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/ida0702410> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id4683a483> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000067182> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7132> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TNFRSF1A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5H7N1> , <https://identifiers.org/uniprot/F5GWJ4> , <https://identifiers.org/uniprot/F5H8A6> , <https://identifiers.org/uniprot/F5H6Z2> , <https://identifiers.org/uniprot/A0A8V8TLL5> , <https://identifiers.org/uniprot/P19438> , <https://identifiers.org/uniprot/F5H6V7> , <https://identifiers.org/uniprot/F5H4T5> , <https://identifiers.org/uniprot/F5H061> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/ad5ed> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F5H6V7> , <http://purl.uniprot.org/uniprot/F5H061> , <http://purl.uniprot.org/uniprot/F5H4T5> , <http://purl.uniprot.org/uniprot/F5H8A6> , <http://purl.uniprot.org/uniprot/F5H6Z2> , <http://purl.uniprot.org/uniprot/P19438> , <http://purl.uniprot.org/uniprot/A0A8V8TLL5> , <http://purl.uniprot.org/uniprot/F5H7N1> , <http://purl.uniprot.org/uniprot/F5GWJ4> ;
        foaf:page           <http://www.uniprot.org/uniprot/P19438> .

<https://identifiers.org/wikipathways/WP5181_r134495>
        rdf:type                wp:Pathway , skos:Collection ;
        dc:identifier           <https://identifiers.org/wikipathways/WP5181> ;
        dc:source               "WikiPathways" ;
        dc:title                "Roles of ceramides in development of insulin resistance"@en ;
        dcterms:description     "Ceramides and insulin resistance are connectedd. Ceramides are accumulated in tissues due to an excess of saturated fatty acids. In obese subjects, the amount of ceramides found in skeletal muscles is nearly double that of healthy subjects. \n\nCeramides are produced mostly by the sphingolipid pathway. Besides the sphingolipid pathway, ceramides are also produced by the hydrolysis of sphingomyelin with the catalysis of nSMase2. \n\nIn the cell, ceramides play a role in insulin resistance. Ceramides inhibit the binding of PDX-1 and MAFA transcription factors to insulin promoter. Ceramides cause ER stress, which activates extracellular signal-regulated kinase MAPK8 and EIF2AK2. This leads to the upregulation of serine phosphorylation while downregulating tyrosine phosphorylation of IRS-1. That, in turn, leads to the inhibition of recruitment and activation of PI3K. This leads to a downregulation in AKT1, an enzyme that stimulates the translocation of GLUT4. Ceramides also impair mitochondria functions and inhibit fatty acid oxidation, eventually leading to ROS and inflammation. Ceramides activate protein PP2A, which promotes the dephosphorylation of AKT1. PKCζ is also activated by ceramides to inhibit the activity of AKT1. \n\nMoreover, palmitoyl-CoA downregulates the phosphorylation of AMPK, which leads to the increase of ER stress in the cell and decreases in fatty acid oxidation. \n\nOn the other hand, oleic acid inhibits the downregulation of AMPK caused by palmitoyl-CoA. Oleic acid also increases the expression of CPT1B, stimulating the fatty acid oxidation to reduce the inflammation in the cell. \n" ;
        dcterms:identifier      "WP5181" ;
        dcterms:references      <https://identifiers.org/pubmed/26078196> , <https://identifiers.org/pubmed/29290500> , <https://identifiers.org/pubmed/23349544> , <https://identifiers.org/pubmed/33738905> ;
        cito:cites              <https://identifiers.org/pubmed/25814122> , <https://identifiers.org/pubmed/29290500> , <https://identifiers.org/pubmed/26078196> , <https://identifiers.org/pubmed/23349544> , <https://identifiers.org/pubmed/33738905> , <https://identifiers.org/pubmed/33033337> , <https://identifiers.org/pubmed/24037260> , <https://identifiers.org/pubmed/19553926> , <https://identifiers.org/pubmed/20182627> , <https://identifiers.org/pubmed/4722436> , <https://identifiers.org/pubmed/23329830> ;
        wp:cellTypeOntologyTag  obo:CL_0000188 ;
        wp:diseaseOntologyTag   obo:DOID_9351 , obo:DOID_1936 , obo:DOID_9970 ;
        wp:isAbout              <http://rdf.wikipathways.org/Pathway/WP5181_r134495> ;
        wp:ontologyTag          wp:Curation:AnalysisCollection , obo:PW_0000208 , obo:DOID_1936 , obo:CL_0000188 , obo:DOID_9970 , obo:PW_0000143 , obo:DOID_9351 ;
        wp:organism             obo:NCBITaxon_9606 ;
        wp:organismName         "Homo sapiens" ;
        wp:pathwayOntologyTag   obo:PW_0000208 , obo:PW_0000143 ;
        foaf:img                <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5181&oldid=134495> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5181&oldid=134495> ;
        foaf:page               <http://www.wikipathways.org/instance/WP5181_r134495> .

<https://identifiers.org/wikipathways/WP2777>
        rdf:type            wp:DataNode , wp:Pathway ;
        rdfs:label          "GLUT4 translocation" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP2777> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP2777" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id56c45eff> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/bc8a2> ;
        foaf:page           <https://www.wikipathways.org/instance/WP2777> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id4683a483>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id4683a483> ;
        wp:participants   <https://identifiers.org/uniprot/P19438> , <https://identifiers.org/uniprot/P01375> ;
        wp:source         <https://identifiers.org/uniprot/P01375> ;
        wp:target         <https://identifiers.org/uniprot/P19438> .

<https://identifiers.org/uniprot/Q8NHW3>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "MAFA" ;
        dc:identifier       <https://identifiers.org/uniprot/Q8NHW3> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q8NHW3" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/25814122> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000182759> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/389692> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAFA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q8NHW3> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/de399> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q8NHW3> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q8NHW3> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id89d104c1>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id89d104c1> ;
        wp:participants   <https://identifiers.org/uniprot/P23443> , <https://identifiers.org/uniprot/Q9UGI9> ;
        wp:source         <https://identifiers.org/uniprot/Q9UGI9> ;
        wp:target         <https://identifiers.org/uniprot/P23443> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id989a1f67>
        rdf:type            wp:Interaction , wp:DirectedInteraction , wp:Conversion ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33738905> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id989a1f67> ;
        wp:participants     <https://identifiers.org/chebi/CHEBI:52639> , <https://identifiers.org/chebi/CHEBI:89490> ;
        wp:source           <https://identifiers.org/chebi/CHEBI:52639> ;
        wp:target           <https://identifiers.org/chebi/CHEBI:89490> .

<https://identifiers.org/uniprot/P06213>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "INSR" ;
        dc:identifier       <https://identifiers.org/uniprot/P06213> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P06213" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8a68d7ee> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171105> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3643> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/INSR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/M0R3E6> , <https://identifiers.org/uniprot/P06213> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/e5d84> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/M0R3E6> , <http://purl.uniprot.org/uniprot/P06213> ;
        foaf:page           <http://www.uniprot.org/uniprot/P06213> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8d212565>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id8d212565> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:15756> .

<https://identifiers.org/uniprot/Q13077>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "TRAF1" ;
        dc:identifier       <https://identifiers.org/uniprot/Q13077> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q13077" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/26078196> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000056558> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7185> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TRAF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q13077> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a6074> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q13077> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q13077> .

<https://identifiers.org/pubmed/29290500>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "29290500" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id7eb7eaa6> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id199b5058> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/29290500> .

<https://identifiers.org/pubmed/26078196>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "26078196" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/O75460> , <https://identifiers.org/uniprot/Q13077> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/26078196> .

<https://identifiers.org/uniprot/Q92523>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "CPT1B" ;
        dc:identifier       <https://identifiers.org/uniprot/Q92523> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q92523" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id290e8371> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id199b5058> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id5bc1f579> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/19553926> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000205560> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1375> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CPT1B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q92523> , <https://identifiers.org/uniprot/A0A024R4W7> , <https://identifiers.org/uniprot/H7C0S1> , <https://identifiers.org/uniprot/C9J7C3> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/d788a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A024R4W7> , <http://purl.uniprot.org/uniprot/Q92523> , <http://purl.uniprot.org/uniprot/H7C0S1> , <http://purl.uniprot.org/uniprot/C9J7C3> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q92523> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/iddc5b3e79>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/iddc5b3e79> ;
        wp:participants   <https://identifiers.org/wikipathways/WP408> , <https://identifiers.org/chebi/CHEBI:26523> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:26523> ;
        wp:target         <https://identifiers.org/wikipathways/WP408> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id56c45eff>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id56c45eff> ;
        wp:participants   <https://identifiers.org/wikipathways/WP2777> , <https://identifiers.org/uniprot/P14672> ;
        wp:source         <https://identifiers.org/uniprot/P14672> ;
        wp:target         <https://identifiers.org/wikipathways/WP2777> .

<https://identifiers.org/uniprot/P23443>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "RPS6KB1" ;
        dc:identifier       <https://identifiers.org/uniprot/P23443> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P23443" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id89d104c1> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000108443> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/6198> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RPS6KB1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/K7ER06> , <https://identifiers.org/uniprot/K7EMM2> , <https://identifiers.org/uniprot/K7EIM2> , <https://identifiers.org/uniprot/P23443> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/b3f7b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/K7EMM2> , <http://purl.uniprot.org/uniprot/K7ER06> , <http://purl.uniprot.org/uniprot/P23443> , <http://purl.uniprot.org/uniprot/K7EIM2> ;
        foaf:page           <http://www.uniprot.org/uniprot/P23443> .

<https://identifiers.org/chebi/CHEBI:52639>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "ceramide" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:52639> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:52639" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8475b052> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id72aabc73> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idb04bf414> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id989a1f67> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:52639> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMSP02010000> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q60537688> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/f0789> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMSP02010000> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:52639> .

<https://identifiers.org/uniprot/P01308>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "Insulin" ;
        dc:identifier       <https://identifiers.org/uniprot/P01308> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P01308" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8a68d7ee> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000254647> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3630> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/INS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A6XGL2> , <https://identifiers.org/uniprot/P01308> , <https://identifiers.org/uniprot/I3WAC9> , <https://identifiers.org/uniprot/C9JNR5> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/fea12> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A6XGL2> , <http://purl.uniprot.org/uniprot/C9JNR5> , <http://purl.uniprot.org/uniprot/P01308> , <http://purl.uniprot.org/uniprot/I3WAC9> ;
        foaf:page           <http://www.uniprot.org/uniprot/P01308> .

<https://identifiers.org/uniprot/P27986>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "PI3K" ;
        dc:identifier       <https://identifiers.org/uniprot/P27986> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P27986" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id21cf08df> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000145675> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5295> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P27986> , <https://identifiers.org/uniprot/B3KWZ7> , <https://identifiers.org/uniprot/A0A8V8TL14> , <https://identifiers.org/uniprot/E5RGI8> , <https://identifiers.org/uniprot/E5RK66> , <https://identifiers.org/uniprot/E5RHI0> , <https://identifiers.org/uniprot/A0A8V8TME9> , <https://identifiers.org/uniprot/A0A8V8TMF4> , <https://identifiers.org/uniprot/A0A8V8TL10> , <https://identifiers.org/uniprot/E5RJY0> , <https://identifiers.org/uniprot/H0YB27> , <https://identifiers.org/uniprot/A0A8V8TLE6> , <https://identifiers.org/uniprot/A0A8V8TMF9> , <https://identifiers.org/uniprot/H0YBC2> , <https://identifiers.org/uniprot/A0A8V8TL31> , <https://identifiers.org/uniprot/A0A8V8TLF7> , <https://identifiers.org/uniprot/A0A8V8TLF1> , <https://identifiers.org/uniprot/A0A2X0SFG1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/d6da3> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E5RK66> , <http://purl.uniprot.org/uniprot/P27986> , <http://purl.uniprot.org/uniprot/B3KWZ7> , <http://purl.uniprot.org/uniprot/A0A8V8TLF1> , <http://purl.uniprot.org/uniprot/A0A8V8TL10> , <http://purl.uniprot.org/uniprot/A0A8V8TMF4> , <http://purl.uniprot.org/uniprot/A0A8V8TL14> , <http://purl.uniprot.org/uniprot/A0A8V8TME9> , <http://purl.uniprot.org/uniprot/A0A8V8TLE6> , <http://purl.uniprot.org/uniprot/A0A2X0SFG1> , <http://purl.uniprot.org/uniprot/E5RHI0> , <http://purl.uniprot.org/uniprot/E5RGI8> , <http://purl.uniprot.org/uniprot/H0YBC2> , <http://purl.uniprot.org/uniprot/E5RJY0> , <http://purl.uniprot.org/uniprot/A0A8V8TMF9> , <http://purl.uniprot.org/uniprot/H0YB27> , <http://purl.uniprot.org/uniprot/A0A8V8TL31> , <http://purl.uniprot.org/uniprot/A0A8V8TLF7> ;
        foaf:page           <http://www.uniprot.org/uniprot/P27986> .

<https://identifiers.org/chebi/CHEBI:15525>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Palmitoyl-CoA" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/MNBKLUUYKPBKDU-BBECNAHFSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:15525> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:15525" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id7eb7eaa6> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idb04bf414> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idcbb4b83c> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:15525> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/559149> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001338> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/MNBKLUUYKPBKDU-BBECNAHFSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00154> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMFA07050360> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID644109> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q28797916> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/db9eb> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMFA07050360> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15525> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id72aabc73>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id72aabc73> ;
        wp:participants   <https://identifiers.org/uniprot/Q05513> , <https://identifiers.org/chebi/CHEBI:52639> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:52639> ;
        wp:target         <https://identifiers.org/uniprot/Q05513> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idcbb4b83c>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/idcbb4b83c> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:15525> , <https://identifiers.org/chebi/CHEBI:15756> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:15756> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:15525> .

<https://identifiers.org/pubmed/33033337>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "33033337" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/ida0702410> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/33033337> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id199b5058>
        rdf:type            wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/29290500> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id199b5058> ;
        wp:participants     <https://identifiers.org/uniprot/Q92523> , <https://identifiers.org/uniprot/Q9UGI9> ;
        wp:source           <https://identifiers.org/uniprot/Q9UGI9> ;
        wp:target           <https://identifiers.org/uniprot/Q92523> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id2bff242a>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id2bff242a> ;
        wp:participants   <https://identifiers.org/uniprot/P14672> , <https://identifiers.org/chebi/CHEBI:17234> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:17234> ;
        wp:target         <https://identifiers.org/uniprot/P14672> .

<https://identifiers.org/uniprot/Q05513>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "PKCzeta" ;
        dc:identifier       <https://identifiers.org/uniprot/Q05513> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q05513" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id72aabc73> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000067606> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5590> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PRKCZ> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D6RBD4> , <https://identifiers.org/uniprot/D6RJG4> , <https://identifiers.org/uniprot/Q05513> , <https://identifiers.org/uniprot/D6RD31> , <https://identifiers.org/uniprot/D6RDM0> , <https://identifiers.org/uniprot/D6RG01> , <https://identifiers.org/uniprot/D6RGG1> , <https://identifiers.org/uniprot/E9PBE1> , <https://identifiers.org/uniprot/D6RAU1> , <https://identifiers.org/uniprot/D6RAN5> , <https://identifiers.org/uniprot/D6RCN4> , <https://identifiers.org/uniprot/F2Z2H9> , <https://identifiers.org/uniprot/F2Z3C5> , <https://identifiers.org/uniprot/J3KRP7> , <https://identifiers.org/uniprot/D6RC84> , <https://identifiers.org/uniprot/D6REZ8> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/aa9f0> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D6RDM0> , <http://purl.uniprot.org/uniprot/F2Z3C5> , <http://purl.uniprot.org/uniprot/D6RAU1> , <http://purl.uniprot.org/uniprot/D6RGG1> , <http://purl.uniprot.org/uniprot/F2Z2H9> , <http://purl.uniprot.org/uniprot/D6REZ8> , <http://purl.uniprot.org/uniprot/D6RJG4> , <http://purl.uniprot.org/uniprot/E9PBE1> , <http://purl.uniprot.org/uniprot/D6RC84> , <http://purl.uniprot.org/uniprot/D6RAN5> , <http://purl.uniprot.org/uniprot/D6RCN4> , <http://purl.uniprot.org/uniprot/Q05513> , <http://purl.uniprot.org/uniprot/D6RG01> , <http://purl.uniprot.org/uniprot/D6RBD4> , <http://purl.uniprot.org/uniprot/D6RD31> , <http://purl.uniprot.org/uniprot/J3KRP7> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q05513> .

<https://identifiers.org/pubmed/20182627>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "20182627" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/P35568> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/20182627> .

<https://identifiers.org/ensembl/ENSG00000142208>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "AKT1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000142208> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000142208" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1d6e1933> , <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id21cf08df> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000142208> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/207> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V2I6> , <https://identifiers.org/uniprot/A0A804HJM6> , <https://identifiers.org/uniprot/A0A087WY56> , <https://identifiers.org/uniprot/G3V3X1> , <https://identifiers.org/uniprot/B0LPE5> , <https://identifiers.org/uniprot/P31749> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17816452> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a1c81> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V3X1> , <http://purl.uniprot.org/uniprot/G3V2I6> , <http://purl.uniprot.org/uniprot/A0A087WY56> , <http://purl.uniprot.org/uniprot/P31749> , <http://purl.uniprot.org/uniprot/A0A804HJM6> , <http://purl.uniprot.org/uniprot/B0LPE5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000142208> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idb04bf414>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/idb04bf414> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:52639> , <https://identifiers.org/chebi/CHEBI:15525> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:15525> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:52639> .

<https://identifiers.org/uniprot/P33121>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "ACSL1" ;
        dc:identifier       <https://identifiers.org/uniprot/P33121> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P33121" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id91de6a48> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000151726> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2180> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ACSL1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P33121> , <https://identifiers.org/uniprot/E7EPM6> , <https://identifiers.org/uniprot/D6RG07> , <https://identifiers.org/uniprot/A0A994J7S4> , <https://identifiers.org/uniprot/B7Z3Z9> , <https://identifiers.org/uniprot/H0Y9U7> , <https://identifiers.org/uniprot/D6RER0> , <https://identifiers.org/uniprot/H0Y9Z9> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/aa5c6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E7EPM6> , <http://purl.uniprot.org/uniprot/P33121> , <http://purl.uniprot.org/uniprot/B7Z3Z9> , <http://purl.uniprot.org/uniprot/H0Y9U7> , <http://purl.uniprot.org/uniprot/D6RER0> , <http://purl.uniprot.org/uniprot/H0Y9Z9> , <http://purl.uniprot.org/uniprot/A0A994J7S4> , <http://purl.uniprot.org/uniprot/D6RG07> ;
        foaf:page           <http://www.uniprot.org/uniprot/P33121> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id7f36fda6>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id7f36fda6> ;
        wp:participants   <https://identifiers.org/uniprot/P16671> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1fc4543> ;
        wp:source         <https://identifiers.org/uniprot/P16671> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1fc4543> .

<https://identifiers.org/wikipathways/WP1422>
        rdf:type            wp:Pathway , wp:DataNode ;
        rdfs:label          "Sphingolipid pathway" ;
        dc:identifier       <https://identifiers.org/wikipathways/WP1422> ;
        dc:source           "WikiPathways" ;
        dcterms:identifier  "WP1422" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idfd9a9ea2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/cde18> ;
        foaf:page           <https://www.wikipathways.org/instance/WP1422> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id5bc1f579>
        rdf:type          wp:Stimulation , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id5bc1f579> ;
        wp:participants   <https://identifiers.org/wikipathways/WP143> , <https://identifiers.org/uniprot/Q92523> ;
        wp:source         <https://identifiers.org/uniprot/Q92523> ;
        wp:target         <https://identifiers.org/wikipathways/WP143> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id91de6a48>
        rdf:type            wp:Catalysis , wp:Interaction , wp:DirectedInteraction ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/4722436> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id91de6a48> ;
        wp:participants     <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idcbb4b83c> , <https://identifiers.org/uniprot/P33121> ;
        wp:source           <https://identifiers.org/uniprot/P33121> ;
        wp:target           <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/idcbb4b83c> .

<https://identifiers.org/hmdb/HMDB0000207>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "OA" , "Oleic acid" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ZQPPMHVWECSIRJ-KTKRTIGZSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0000207> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0000207" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id290e8371> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1fc4543> , <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:16196> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/393217> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000207> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ZQPPMHVWECSIRJ-KTKRTIGZSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00712> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMFA01030002> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID445639> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q207688> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/c388a> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a7b36> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMFA01030002> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0000207> .

<https://identifiers.org/wikipathways/WP5181>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP5181_r134495> .

<https://identifiers.org/uniprot/O75460>
        rdf:type            wp:Protein , wp:DataNode ;
        rdfs:label          "ERN1" ;
        dc:identifier       <https://identifiers.org/uniprot/O75460> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "O75460" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/26078196> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000178607> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2081> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ERN1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A7P0TA38> , <https://identifiers.org/uniprot/O75460> , <https://identifiers.org/uniprot/A0A7P0TAB0> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/cb578> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O75460> , <http://purl.uniprot.org/uniprot/A0A7P0TA38> , <http://purl.uniprot.org/uniprot/A0A7P0TAB0> ;
        foaf:page           <http://www.uniprot.org/uniprot/O75460> .

<https://identifiers.org/pubmed/25814122>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "25814122" ;
        dcterms:isPartOf    <https://identifiers.org/uniprot/P52945> , <https://identifiers.org/uniprot/Q8NHW3> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/25814122> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id4caa4577>
        rdf:type            wp:Interaction , wp:DirectedInteraction , wp:Catalysis ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        dcterms:references  <https://identifiers.org/pubmed/33738905> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id4caa4577> ;
        wp:participants     <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8475b052> , <https://identifiers.org/uniprot/Q9NY59> ;
        wp:source           <https://identifiers.org/uniprot/Q9NY59> ;
        wp:target           <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8475b052> .

<https://identifiers.org/ensembl/ENSG00000055332>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "EIF2AK2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000055332> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000055332" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000055332> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5610> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EIF2AK2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P19525> , <https://identifiers.org/uniprot/A0A7P0Z4M0> , <https://identifiers.org/uniprot/A0A7P0TAL9> , <https://identifiers.org/uniprot/A0A7P0TBA9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14905690> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a1bf8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A7P0TBA9> , <http://purl.uniprot.org/uniprot/A0A7P0Z4M0> , <http://purl.uniprot.org/uniprot/A0A7P0TAL9> , <http://purl.uniprot.org/uniprot/P19525> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000055332> .

<https://identifiers.org/chebi/CHEBI:26523>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "ROS" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:26523> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "26523" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/iddc5b3e79> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:26523> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q424361> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/a3352> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26523> .

<https://identifiers.org/uniprot/P01375>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "TNF-alpha" ;
        dc:identifier       <https://identifiers.org/uniprot/P01375> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "P01375" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id4683a483> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000232810> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/7124> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/TNF> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TNL2> , <https://identifiers.org/uniprot/Q5STB3> , <https://identifiers.org/uniprot/P01375> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/d9b95> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q5STB3> , <http://purl.uniprot.org/uniprot/P01375> , <http://purl.uniprot.org/uniprot/A0A8V8TNL2> ;
        foaf:page           <http://www.uniprot.org/uniprot/P01375> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5181&oldid=134495>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id273e207>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id273e207> ;
        wp:participants   <https://identifiers.org/uniprot/P16671> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8d212565> ;
        wp:source         <https://identifiers.org/uniprot/P16671> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8d212565> .

<https://identifiers.org/chebi/CHEBI:89490>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Sphingomyelin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/FONAXCRWZQFJHY-JCGOJSMZSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:89490> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:89490" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id989a1f67> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id8475b052> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:89490> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/24846880> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0012091> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/FONAXCRWZQFJHY-JCGOJSMZSA-N> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMSP03010022> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID44260132> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27161682> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/c1453> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMSP03010022> , <https://swisslipids.org/rdf/SLM_000395859> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:89490> .

<http://rdf.wikipathways.org/Pathway/WP5181_r134495/WP/Interaction/id1fc4543>
        rdf:type          wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5181_r134495/Interaction/id1fc4543> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0000207> .

<https://identifiers.org/pubmed/23349544>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "23349544" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/23349544> .

<https://identifiers.org/uniprot/Q9Y4H2>
        rdf:type            wp:DataNode , wp:Protein ;
        rdfs:label          "IRS-2" ;
        dc:identifier       <https://identifiers.org/uniprot/Q9Y4H2> ;
        dc:source           "UniProtKB" ;
        dcterms:identifier  "Q9Y4H2" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5181_r134495> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000185950> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/8660> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IRS2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q9Y4H2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/c9ba5> , <http://rdf.wikipathways.org/Pathway/WP5181_r134495/DataNode/db3b9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9Y4H2> ;
        foaf:page           <http://www.uniprot.org/uniprot/Q9Y4H2> .
