@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/e43ba>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/e43ba> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0004246> , <https://identifiers.org/ncbigene/424957> ;
        wp:source         <https://identifiers.org/ncbigene/424957> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0004246> .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/cfa86>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/cfa86> ;
        wp:participants   <https://identifiers.org/ncbigene/428906> , <https://identifiers.org/hmdb/HMDB0004246> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0004246> ;
        wp:target         <https://identifiers.org/ncbigene/428906> .

<https://identifiers.org/hmdb/HMDB0001035>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin II" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/CZGUSIXMZVURDU-JZXHSEFVSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0001035> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0001035" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/fb225> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/da140> , <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:2719> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/150504> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/CZGUSIXMZVURDU-JZXHSEFVSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C02135> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID172198> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q412999> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/ff099> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0001035> .

<https://identifiers.org/kegg.compound/C01780>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Aldosterone" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/PQSUYGKTWSAVDQ-ZVIOFETBSA-N> ;
        dc:identifier       <https://identifiers.org/kegg.compound/C01780> ;
        dc:source           "KEGG Compound" ;
        dcterms:identifier  "C01780" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/b6d55> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:27584> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/5633> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0000037> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/PQSUYGKTWSAVDQ-ZVIOFETBSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C01780> ;
        wp:bdbLipidMaps     <https://identifiers.org/lipidmaps/LMST02030026> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5839> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q184564> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/e48f5> ;
        owl:sameAs          <https://www.lipidmaps.org/rdf/LMST02030026> , <https://swisslipids.org/rdf/SLM_000485683> ;
        foaf:page           <http://www.genome.jp/dbget-bin/www_bget?cpd:C01780> .

obo:NCBITaxon_9031  obo:NCIT_C179773  "9031" .

<https://identifiers.org/pubmed/17464936>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "17464936" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/17464936> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP801&oldid=117188>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/d17d9>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/d17d9> ;
        wp:participants   <https://identifiers.org/ncbigene/419953> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/da140> ;
        wp:source         <https://identifiers.org/ncbigene/419953> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/da140> .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/da140>
        rdf:type          wp:Conversion , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/da140> ;
        wp:participants   <https://identifiers.org/hmdb/HMDB0001035> , <https://identifiers.org/pubchem.compound/3081372> ;
        wp:source         <https://identifiers.org/pubchem.compound/3081372> ;
        wp:target         <https://identifiers.org/hmdb/HMDB0001035> .

<https://identifiers.org/ncbigene/396065>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AGTR1" ;
        dc:identifier       <https://identifiers.org/ncbigene/396065> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "396065" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/fb225> , <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSGALG00010017056> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/396065> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P79785> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/bb8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P79785> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/396065> .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/b6d55>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/b6d55> ;
        wp:participants   <https://identifiers.org/kegg.compound/C01780> , <https://identifiers.org/ncbigene/428708> ;
        wp:source         <https://identifiers.org/ncbigene/428708> ;
        wp:target         <https://identifiers.org/kegg.compound/C01780> .

<https://identifiers.org/ncbigene/424957>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KNG1" ;
        dc:identifier       <https://identifiers.org/ncbigene/424957> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "424957" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/e43ba> , <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSGALG00010016206> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/424957> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KNG1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/ac4> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/424957> .

<https://identifiers.org/pubchem.compound/3081372>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Angiotensin I" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/ORWYRWWVDCYOMK-HBZPZAIKSA-N> ;
        dc:identifier       <https://identifiers.org/pubchem.compound/3081372> ;
        dc:source           "PubChem-compound" ;
        dcterms:identifier  "3081372" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/eebe1> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/da140> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:2718> , <https://identifiers.org/chebi/CHEBI:147350> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/23150106> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0061196> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/ORWYRWWVDCYOMK-HBZPZAIKSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00873> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID90657349> , <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3081372> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q539799> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/b0bb0> ;
        foaf:page           <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3081372> .

<https://identifiers.org/wikipathways/WP801_r117188>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP801> ;
        dc:source              "WikiPathways" ;
        dc:title               "ACE inhibitor pathway"@en ;
        dcterms:description    "The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists.\nSource: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)" ;
        dcterms:identifier     "WP801" ;
        dcterms:references     <https://identifiers.org/pubmed/17464936> ;
        cito:cites             <https://identifiers.org/pubmed/17464936> ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP801_r117188> ;
        wp:ontologyTag         wp:Curation:Homology_Converted , obo:PW_0001228 , wp:Curation:AnalysisCollection ;
        wp:organism            obo:NCBITaxon_9031 ;
        wp:organismName        "Gallus gallus" ;
        wp:pathwayOntologyTag  obo:PW_0001228 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP801&oldid=117188> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP801&oldid=117188> ;
        foaf:page              <http://www.wikipathways.org/instance/WP801_r117188> .

<https://identifiers.org/ncbigene/419953>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "ACE" ;
        dc:identifier       <https://identifiers.org/ncbigene/419953> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "419953" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/d17d9> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSGALG00010023369> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/419953> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/c6c> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/ab9> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/419953> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP801&oldid=117188>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/eebe1>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/eebe1> ;
        wp:participants   <https://identifiers.org/pubchem.compound/3081372> , <https://identifiers.org/ncbigene/421543> ;
        wp:source         <https://identifiers.org/ncbigene/421543> ;
        wp:target         <https://identifiers.org/pubchem.compound/3081372> .

<http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/fb225>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP801_r117188/Interaction/fb225> ;
        wp:participants   <https://identifiers.org/ncbigene/396065> , <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:source         <https://identifiers.org/hmdb/HMDB0001035> ;
        wp:target         <https://identifiers.org/ncbigene/396065> .

<https://identifiers.org/ncbigene/421543>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AGT" ;
        dc:identifier       <https://identifiers.org/ncbigene/421543> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "421543" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/eebe1> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSGALG00010007759> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/421543> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/a57> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/421543> .

<https://identifiers.org/hmdb/HMDB0004246>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Bradykinin" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/QXZGBUJJYSLZLT-FDISYFBBSA-N> ;
        dc:identifier       <https://identifiers.org/hmdb/HMDB0004246> ;
        dc:source           "HMDB" ;
        dcterms:identifier  "HMDB0004246" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/cfa86> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/e43ba> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:3165> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/388341> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0004246> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/QXZGBUJJYSLZLT-FDISYFBBSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C00306> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439201> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q24745328> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/f0af8> ;
        foaf:page           <http://www.hmdb.ca/metabolites/HMDB0004246> .

<https://identifiers.org/ncbigene/428708>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AGTR2" ;
        dc:identifier       <https://identifiers.org/ncbigene/428708> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "428708" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/b6d55> , <https://identifiers.org/wikipathways/WP801_r117188> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSGALG00010018860> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/428708> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AGTR2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/d4b> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/428708> .

<https://identifiers.org/ncbigene/428906>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "BDKRB2" ;
        dc:identifier       <https://identifiers.org/ncbigene/428906> ;
        dc:source           "Entrez Gene" ;
        dcterms:identifier  "428906" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP801_r117188> , <http://rdf.wikipathways.org/Pathway/WP801_r117188/WP/Interaction/cfa86> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSGALG00010015588> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/428906> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP801_r117188/DataNode/ede> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/gene/428906> .

<https://identifiers.org/wikipathways/WP801>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP801_r117188> .
