@prefix biopax:  <http://www.biopax.org/release/biopax-level3.owl#> .
@prefix cito:    <http://purl.org/spar/cito/> .
@prefix dc:      <http://purl.org/dc/elements/1.1/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .
@prefix freq:    <http://purl.org/cld/freq/> .
@prefix gpml:    <http://vocabularies.wikipathways.org/gpml#> .
@prefix obo:     <http://purl.obolibrary.org/obo/> .
@prefix owl:     <http://www.w3.org/2002/07/owl#> .
@prefix pav:     <http://purl.org/pav/> .
@prefix prov:    <http://www.w3.org/ns/prov#> .
@prefix rdf:     <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos:    <http://www.w3.org/2004/02/skos/core#> .
@prefix void:    <http://rdfs.org/ns/void#> .
@prefix wp:      <http://vocabularies.wikipathways.org/wp#> .
@prefix wprdf:   <http://rdf.wikipathways.org/> .
@prefix xsd:     <http://www.w3.org/2001/XMLSchema#> .

<https://identifiers.org/ensembl/ENSG00000100030>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000100030> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000100030" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000100030> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5594> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q1HBJ4> , <https://identifiers.org/uniprot/P28482> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15317730> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ea366> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P28482> , <http://purl.uniprot.org/uniprot/Q1HBJ4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000100030> .

<https://identifiers.org/ensembl/ENSG00000118907>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K7" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000118907> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000118907" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000118907> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/deb7c> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000118907> .

<https://identifiers.org/chebi/CHEBI:132893>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Fangchinoline" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/IIQSJHUEZBTSAT-VMPREFPWSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:132893> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:132893" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/fdafd> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:132893> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/66173> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/IIQSJHUEZBTSAT-VMPREFPWSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID73481> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15410976> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e1419> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:132893> .

<https://identifiers.org/ensembl/ENSG00000111276>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CDKN1B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000111276> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000111276" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000111276> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1027> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDKN1B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C2T1> , <https://identifiers.org/uniprot/P46527> , <https://identifiers.org/uniprot/E7ES52> , <https://identifiers.org/uniprot/Q6I9V6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20969983> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e9f8e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/H7C2T1> , <http://purl.uniprot.org/uniprot/Q6I9V6> , <http://purl.uniprot.org/uniprot/P46527> , <http://purl.uniprot.org/uniprot/E7ES52> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000111276> .

<https://identifiers.org/drugbank/DB01006>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Letrozole" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/HPJKCIUCZWXJDR-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB01006> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB01006" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:6413> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/3765> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0015141> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/HPJKCIUCZWXJDR-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C08163> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3902> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q194974> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f8115> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB01006> .

<https://identifiers.org/ensembl/ENSG00000105810>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CDK6" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105810> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105810" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/e0d74> , <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105810> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1021> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDK6> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q00534> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911762> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b0a41> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q00534> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105810> .

<https://identifiers.org/wikipathways/WP5497_r142315>
        rdf:type               skos:Collection , wp:Pathway ;
        dc:identifier          <https://identifiers.org/wikipathways/WP5497> ;
        dc:source              "WikiPathways" ;
        dc:title               "Cyclin-dependent kinase 4/6 inhibitors in breast cancer"@en ;
        dcterms:description    "\"Signaling pathways associated with tumorigenesis and combined treatments that alleviate drug resistance. Pharmaceutical CDK4/6 inhibitors palbociclib, ribociclib, and abemaciclib directly inhibit CDK4/6 activity. Moreover, the upstream mitogenic forces, including the canonical RAS-RAF-MEK-ERK pathway, heightened activity of the HER2-PI3K-AKT-mTOR axis, increase the cyclin D1 levels, activating CDK4/6 and promoting cellular progression to the S phase. Because of this foundation, PI3K, mTOR and MEK inhibitors induce synergistic anti-proliferative and pro-apoptotic effects, which lead to more durable cell cycle arrest and a delay to the onset of resistance. The Aromatase Inhibitors (AI), which inhibit the transformation of androgen into estradiol, thereby suppress breast cancer cell growth. Selective estrogen receptor modulator (SERM) and selective estrogen receptor downregulator (SERD) can affect estrogen receptors to produce the same inhibitory effect on tumor cells. ALT can keep p27 in a non-phosphorylated state, which is a stable form, and reduce both CDK2 and CDK4 activity. BMP4 and Fangchinoline can upregulate p21. Fangchinoline not only increases the level of CKIs (p21 and p27), but also inhibits cyclin D1/D3/E and CDK2/4/6. The ALT, BMP4 and Fangchinoline are still under preclinical study. In addition, clinical studies on the combination of CDK4/6 inhibitors with anti-HER2 therapy and immunotherapy are under way.\"  Source: Figure F2 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775706.  Derived from https://pfocr.wikipathways.org/figures/PMC6775706__jcav10p5504g002.html." ;
        dcterms:identifier     "WP5497" ;
        dcterms:references     <https://identifiers.org/pubmed/31632494> ;
        cito:cites             <https://identifiers.org/pubmed/31632494> ;
        wp:diseaseOntologyTag  obo:DOID_1612 ;
        wp:isAbout             <http://rdf.wikipathways.org/Pathway/WP5497_r142315> ;
        wp:ontologyTag         wp:Curation:AnalysisCollection , obo:PW_0000624 , wp:Curation:CPTAC , obo:DOID_1612 , obo:PW_0002367 , obo:PW_0000754 ;
        wp:organism            obo:NCBITaxon_9606 ;
        wp:organismName        "Homo sapiens" ;
        wp:pathwayOntologyTag  obo:PW_0000624 , obo:PW_0002367 , obo:PW_0000754 ;
        foaf:img               <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5497&oldid=142315> , <https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5497&oldid=142315> ;
        foaf:page              <http://www.wikipathways.org/instance/WP5497_r142315> .

<https://identifiers.org/ensembl/ENSG00000105173>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CCNE1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105173> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105173" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/fef50> , <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105173> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/898> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CCNE1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/I3L1Q9> , <https://identifiers.org/uniprot/C9J2U0> , <https://identifiers.org/uniprot/P24864> , <https://identifiers.org/uniprot/I3L413> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q5198275> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/d4811> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/I3L413> , <http://purl.uniprot.org/uniprot/I3L1Q9> , <http://purl.uniprot.org/uniprot/P24864> , <http://purl.uniprot.org/uniprot/C9J2U0> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105173> .

<https://identifiers.org/drugbank/DB00539>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Toremifene" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/XFCLJVABOIYOMF-QPLCGJKRSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB00539> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB00539" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:9635> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/2275722> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0014679> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/XFCLJVABOIYOMF-QPLCGJKRSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C08166> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID3005573> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q3993743> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ee968> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB00539> .

<https://identifiers.org/ensembl/ENSG00000105851>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3CG" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105851> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105851" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105851> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5294> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CG> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P48736> , <https://identifiers.org/uniprot/A0A024R720> , <https://identifiers.org/uniprot/E9PDN7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030551> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/bf31a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P48736> , <http://purl.uniprot.org/uniprot/A0A024R720> , <http://purl.uniprot.org/uniprot/E9PDN7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105851> .

<https://identifiers.org/ensembl/ENSG00000141506>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PIK3R5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000141506> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000141506" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000141506> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/23533> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R5> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/L7RT34> , <https://identifiers.org/uniprot/J3KT66> , <https://identifiers.org/uniprot/Q8WYR1> , <https://identifiers.org/uniprot/J3KRE9> , <https://identifiers.org/uniprot/J3KSW1> , <https://identifiers.org/uniprot/X6R3K3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18037249> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b306a> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3KT66> , <http://purl.uniprot.org/uniprot/J3KSW1> , <http://purl.uniprot.org/uniprot/Q8WYR1> , <http://purl.uniprot.org/uniprot/L7RT34> , <http://purl.uniprot.org/uniprot/J3KRE9> , <http://purl.uniprot.org/uniprot/X6R3K3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000141506> .

<https://identifiers.org/ensembl/ENSG00000276231>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3R6" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000276231> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000276231" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000276231> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/146850> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R6> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5UE93> , <https://identifiers.org/uniprot/A0A087X1F3> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18051483> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c416b> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087X1F3> , <http://purl.uniprot.org/uniprot/Q5UE93> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000276231> .

<https://identifiers.org/ensembl/ENSG00000011405>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3C2A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000011405> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000011405" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000011405> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5286> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3C2A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A0C4DGF9> , <https://identifiers.org/uniprot/O00443> , <https://identifiers.org/uniprot/E9PPP3> , <https://identifiers.org/uniprot/L7RRS0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030545> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/bb870> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c9660> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PPP3> , <http://purl.uniprot.org/uniprot/O00443> , <http://purl.uniprot.org/uniprot/L7RRS0> , <http://purl.uniprot.org/uniprot/A0A0C4DGF9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000011405> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/ee192>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/ee192> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000198793> , <https://identifiers.org/ensembl/ENSG00000141564> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idbcd6a84e>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/idbcd6a84e> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:23965> , <https://identifiers.org/chebi/CHEBI:50113> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:50113> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:23965> .

<https://identifiers.org/ensembl/ENSG00000051382>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PIK3CB" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000051382> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000051382" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000051382> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5291> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CB> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H7C565> , <https://identifiers.org/uniprot/H7C5C3> , <https://identifiers.org/uniprot/H0Y871> , <https://identifiers.org/uniprot/C9JYX0> , <https://identifiers.org/uniprot/H7C527> , <https://identifiers.org/uniprot/C9J345> , <https://identifiers.org/uniprot/P42338> , <https://identifiers.org/uniprot/F8WDJ8> , <https://identifiers.org/uniprot/Q68DL0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030549> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f6c9d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P42338> , <http://purl.uniprot.org/uniprot/Q68DL0> , <http://purl.uniprot.org/uniprot/H7C527> , <http://purl.uniprot.org/uniprot/H7C565> , <http://purl.uniprot.org/uniprot/H7C5C3> , <http://purl.uniprot.org/uniprot/C9J345> , <http://purl.uniprot.org/uniprot/H0Y871> , <http://purl.uniprot.org/uniprot/C9JYX0> , <http://purl.uniprot.org/uniprot/F8WDJ8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000051382> .

<https://identifiers.org/ensembl/ENSG00000121879>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PIK3CA" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000121879> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000121879" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000121879> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5290> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CA> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P42336> , <https://identifiers.org/uniprot/A0A2R8Y2F6> , <https://identifiers.org/uniprot/A0A6Q8PGV1> , <https://identifiers.org/uniprot/C9JAM9> , <https://identifiers.org/uniprot/C9J951> , <https://identifiers.org/uniprot/A0A6Q8PGN9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14887700> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ee2f2> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/C9J951> , <http://purl.uniprot.org/uniprot/C9JAM9> , <http://purl.uniprot.org/uniprot/P42336> , <http://purl.uniprot.org/uniprot/A0A2R8Y2F6> , <http://purl.uniprot.org/uniprot/A0A6Q8PGV1> , <http://purl.uniprot.org/uniprot/A0A6Q8PGN9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000121879> .

<https://identifiers.org/ensembl/ENSG00000138015>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K5" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000138015> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000138015" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000138015> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/d8635> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000138015> .

<https://identifiers.org/ensembl/ENSG00000107356>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000107356> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000107356" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000107356> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/fb04a> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000107356> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/fdafd>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/fdafd> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000124762> , <https://identifiers.org/chebi/CHEBI:132893> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:132893> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000124762> .

<https://identifiers.org/drugbank/DB01259>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Lapatinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BCFGMOOMADDAQU-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB01259> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB01259" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:49603> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/181006> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0015388> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BCFGMOOMADDAQU-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID208908> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q420323> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/db07a> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB01259> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/e0d74>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/e0d74> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000110092> , <https://identifiers.org/ensembl/ENSG00000105810> .

<https://identifiers.org/ensembl/ENSG00000213281>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "NRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000213281> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000213281" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000213281> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/4893> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/NRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5U091> , <https://identifiers.org/uniprot/P01111> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030215> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a30ae> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01111> , <http://purl.uniprot.org/uniprot/Q5U091> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000213281> .

<https://identifiers.org/ensembl/ENSG00000133703>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "KRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000133703> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000133703" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000133703> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3845> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/KRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V4K2> , <https://identifiers.org/uniprot/G3V5T7> , <https://identifiers.org/uniprot/L7RSL8> , <https://identifiers.org/uniprot/A0A024RAV5> , <https://identifiers.org/uniprot/A0A8I5KUB5> , <https://identifiers.org/uniprot/A0A8I5KYH6> , <https://identifiers.org/uniprot/A0A8I5KQU3> , <https://identifiers.org/uniprot/A0A8I5KR86> , <https://identifiers.org/uniprot/A0A8I5KXN3> , <https://identifiers.org/uniprot/P01116> , <https://identifiers.org/uniprot/A0A8I5KQ21> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20969980> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c5d53> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KUB5> , <http://purl.uniprot.org/uniprot/L7RSL8> , <http://purl.uniprot.org/uniprot/P01116> , <http://purl.uniprot.org/uniprot/A0A8I5KXN3> , <http://purl.uniprot.org/uniprot/G3V4K2> , <http://purl.uniprot.org/uniprot/A0A8I5KYH6> , <http://purl.uniprot.org/uniprot/A0A8I5KR86> , <http://purl.uniprot.org/uniprot/A0A024RAV5> , <http://purl.uniprot.org/uniprot/A0A8I5KQU3> , <http://purl.uniprot.org/uniprot/A0A8I5KQ21> , <http://purl.uniprot.org/uniprot/G3V5T7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000133703> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/ComplexBinding/fef50>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/fef50> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000105173> , <https://identifiers.org/ensembl/ENSG00000123374> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/fef50> .

<https://identifiers.org/ensembl/ENSG00000101418>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000101418> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000101418" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000101418> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b2abf> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000101418> .

<https://identifiers.org/wikipathways/WP5497>
        pav:hasVersion  <https://identifiers.org/wikipathways/WP5497_r142315> .

<https://identifiers.org/ensembl/ENSG00000169047>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "IRS1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000169047> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000169047" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idba62686d> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000169047> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3667> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IRS1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P35568> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15334084> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f057d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P35568> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000169047> .

<https://identifiers.org/drugbank/DB11730>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Ribociclib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/RHXHGRAEPCAFML-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB11730> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB11730" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:230905> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/30798107> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0257211> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/RHXHGRAEPCAFML-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID44631912> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q27088552> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/eb5a2> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB11730> .

<https://identifiers.org/drugbank/DBCAT005750>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "PI3Ki" ;
        dc:identifier       <https://identifiers.org/drugbank/DBCAT005750> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DBCAT005750" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f3fd7> ;
        foaf:page           <http://www.drugbank.ca/drugs/DBCAT005750> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/ec38f>
        rdf:type          wp:Inhibition , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/ec38f> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:23965> , <https://identifiers.org/drugbank/DB00947> ;
        wp:source         <https://identifiers.org/drugbank/DB00947> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:23965> .

<https://identifiers.org/drugbank/DB11828>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Neratinib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/JWNPDZNEKVCWMY-VQHVLOKHSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB11828> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB11828" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:61397> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/8091392> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/JWNPDZNEKVCWMY-VQHVLOKHSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9915743> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q6995920> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b618f> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB11828> .

<https://identifiers.org/ensembl/ENSG00000146648>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "EGFR" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000146648> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000146648" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000146648> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1956> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/EGFR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/C9JYS6> , <https://identifiers.org/uniprot/P00533> , <https://identifiers.org/uniprot/A0A8V8TPW8> , <https://identifiers.org/uniprot/Q504U8> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14865565> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e04d2> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c23e6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P00533> , <http://purl.uniprot.org/uniprot/A0A8V8TPW8> , <http://purl.uniprot.org/uniprot/C9JYS6> , <http://purl.uniprot.org/uniprot/Q504U8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000146648> .

<https://identifiers.org/drugbank/DB01217>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Anastrozole" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/YBBLVLTVTVSKRW-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB01217> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB01217" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:2704> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/2102> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0015348> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/YBBLVLTVTVSKRW-UHFFFAOYSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C08159> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID2187> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q419143> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/bdda2> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB01217> .

<https://identifiers.org/pubmed/31632494>
        rdf:type            wp:PublicationReference ;
        dc:source           "PubMed" ;
        dcterms:identifier  "31632494" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        foaf:page           <http://www.ncbi.nlm.nih.gov/pubmed/31632494> .

<https://identifiers.org/ensembl/ENSG00000196455>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3R4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000196455> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000196455" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000196455> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/30849> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/D6RJ98> , <https://identifiers.org/uniprot/D6RAC3> , <https://identifiers.org/uniprot/D6RBB7> , <https://identifiers.org/uniprot/Q99570> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18039795> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b8705> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/D6RAC3> , <http://purl.uniprot.org/uniprot/Q99570> , <http://purl.uniprot.org/uniprot/D6RJ98> , <http://purl.uniprot.org/uniprot/D6RBB7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000196455> .

<https://identifiers.org/ensembl/ENSG00000115669>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MAP2K4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000115669> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000115669" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000115669> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/aa278> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000115669> .

<https://identifiers.org/ensembl/ENSG00000091831>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ESR1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000091831> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000091831" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/b006d> , <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000091831> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2099> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ESR1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0Y4W6> , <https://identifiers.org/uniprot/Q9H2M2> , <https://identifiers.org/uniprot/Q9H2M1> , <https://identifiers.org/uniprot/B0QYW7> , <https://identifiers.org/uniprot/Q5T5H8> , <https://identifiers.org/uniprot/Q9UE35> , <https://identifiers.org/uniprot/G4XH65> , <https://identifiers.org/uniprot/P03372> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14902310> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e61b1> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q9H2M2> , <http://purl.uniprot.org/uniprot/B0QYW7> , <http://purl.uniprot.org/uniprot/Q9H2M1> , <http://purl.uniprot.org/uniprot/G4XH65> , <http://purl.uniprot.org/uniprot/Q9UE35> , <http://purl.uniprot.org/uniprot/P03372> , <http://purl.uniprot.org/uniprot/H0Y4W6> , <http://purl.uniprot.org/uniprot/Q5T5H8> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000091831> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idf1a1fb9f>
        rdf:type          wp:Catalysis , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/idf1a1fb9f> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000137869> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idbcd6a84e> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000137869> ;
        wp:target         <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idbcd6a84e> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/fef50>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/fef50> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000105173> , <https://identifiers.org/ensembl/ENSG00000123374> .

obo:NCBITaxon_9606  obo:NCIT_C179773  "9606" .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idba62686d>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/idba62686d> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000169047> , <https://identifiers.org/ensembl/ENSG00000140443> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000140443> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000169047> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP5497&oldid=142315>
        rdf:type        foaf:Image ;
        dcterms:format  "image/svg+xml" .

<https://identifiers.org/ensembl/ENSG00000124762>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CDKN1A" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000124762> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000124762" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/fdafd> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000124762> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1026> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDKN1A> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P38936> , <https://identifiers.org/uniprot/A0A024RCX5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14902453> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/af042> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P38936> , <http://purl.uniprot.org/uniprot/A0A024RCX5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000124762> .

<https://identifiers.org/drugbank/DB09073>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Palbociclib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/AHJRHEGDXFFMBM-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB09073> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB09073" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:85993> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/4487437> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0256084> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/AHJRHEGDXFFMBM-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5330286> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15269707> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b899b> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB09073> .

<https://identifiers.org/ensembl/ENSG00000105647>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3R2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105647> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105647" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105647> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5296> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O00459> , <https://identifiers.org/uniprot/A0A7I2U3A3> , <https://identifiers.org/uniprot/A0A087X257> , <https://identifiers.org/uniprot/A0A5F9ZHY3> , <https://identifiers.org/uniprot/V9GYJ4> , <https://identifiers.org/uniprot/E9PFP1> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/fe9b8> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O00459> , <http://purl.uniprot.org/uniprot/V9GYJ4> , <http://purl.uniprot.org/uniprot/A0A5F9ZHY3> , <http://purl.uniprot.org/uniprot/E9PFP1> , <http://purl.uniprot.org/uniprot/A0A087X257> , <http://purl.uniprot.org/uniprot/A0A7I2U3A3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105647> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/b006d>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/b006d> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:23965> , <https://identifiers.org/ensembl/ENSG00000091831> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000091831> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:23965> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/ComplexBinding/f5215>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/f5215> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000135446> , <https://identifiers.org/ensembl/ENSG00000110092> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/f5215> .

<https://identifiers.org/ensembl/ENSG00000198793>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MTOR" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000198793> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000198793" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/ee192> , <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000198793> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2475> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MTOR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TRG9> , <https://identifiers.org/uniprot/A0A8V8TR74> , <https://identifiers.org/uniprot/A0A8V8TQN3> , <https://identifiers.org/uniprot/A0A8V8TQM6> , <https://identifiers.org/uniprot/A0A8V8TQ52> , <https://identifiers.org/uniprot/P42345> , <https://identifiers.org/uniprot/A0A8V8TQP2> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14876086> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e0763> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P42345> , <http://purl.uniprot.org/uniprot/A0A8V8TQP2> , <http://purl.uniprot.org/uniprot/A0A8V8TQ52> , <http://purl.uniprot.org/uniprot/A0A8V8TQM6> , <http://purl.uniprot.org/uniprot/A0A8V8TRG9> , <http://purl.uniprot.org/uniprot/A0A8V8TR74> , <http://purl.uniprot.org/uniprot/A0A8V8TQN3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000198793> .

<https://identifiers.org/ensembl/ENSG00000107958>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAP2K3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000107958> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000107958" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000107958> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/dcbb7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000107958> .

<https://identifiers.org/ensembl/ENSG00000145675>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "PIK3R1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000145675> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000145675" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000145675> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5295> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B3KWZ7> , <https://identifiers.org/uniprot/E5RK66> , <https://identifiers.org/uniprot/H0YBC2> , <https://identifiers.org/uniprot/A0A8V8TMF9> , <https://identifiers.org/uniprot/H0YB27> , <https://identifiers.org/uniprot/P27986> , <https://identifiers.org/uniprot/A0A8V8TL14> , <https://identifiers.org/uniprot/E5RHI0> , <https://identifiers.org/uniprot/A0A8V8TMF4> , <https://identifiers.org/uniprot/A0A8V8TL10> , <https://identifiers.org/uniprot/A0A8V8TLF1> , <https://identifiers.org/uniprot/A0A8V8TME9> , <https://identifiers.org/uniprot/A0A8V8TL31> , <https://identifiers.org/uniprot/A0A8V8TLE6> , <https://identifiers.org/uniprot/E5RJY0> , <https://identifiers.org/uniprot/A0A2X0SFG1> , <https://identifiers.org/uniprot/E5RGI8> , <https://identifiers.org/uniprot/A0A8V8TLF7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q20969988> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/acd9f> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E5RK66> , <http://purl.uniprot.org/uniprot/A0A8V8TMF9> , <http://purl.uniprot.org/uniprot/A0A8V8TMF4> , <http://purl.uniprot.org/uniprot/B3KWZ7> , <http://purl.uniprot.org/uniprot/A0A8V8TL10> , <http://purl.uniprot.org/uniprot/A0A8V8TL14> , <http://purl.uniprot.org/uniprot/A0A2X0SFG1> , <http://purl.uniprot.org/uniprot/A0A8V8TME9> , <http://purl.uniprot.org/uniprot/E5RHI0> , <http://purl.uniprot.org/uniprot/H0YBC2> , <http://purl.uniprot.org/uniprot/E5RJY0> , <http://purl.uniprot.org/uniprot/A0A8V8TL31> , <http://purl.uniprot.org/uniprot/A0A8V8TLF1> , <http://purl.uniprot.org/uniprot/A0A8V8TLE6> , <http://purl.uniprot.org/uniprot/A0A8V8TLF7> , <http://purl.uniprot.org/uniprot/E5RGI8> , <http://purl.uniprot.org/uniprot/H0YB27> , <http://purl.uniprot.org/uniprot/P27986> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000145675> .

<https://identifiers.org/drugbank/DB12001>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Abemaciclib" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/UZWDCWONPYILKI-UHFFFAOYSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB12001> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB12001" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:233362> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/29340700> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0247749> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/UZWDCWONPYILKI-UHFFFAOYSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID46220502> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q23901483> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e2c9b> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB12001> .

<https://identifiers.org/ensembl/ENSG00000117461>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3R3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000117461> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000117461" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000117461> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/8503> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3R3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q5T4P3> , <https://identifiers.org/uniprot/Q92569> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18032990> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/df8e5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q92569> , <http://purl.uniprot.org/uniprot/Q5T4P3> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000117461> .

<https://identifiers.org/ensembl/ENSG00000141736>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "ERBB2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000141736> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000141736" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000141736> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/2064> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/ERBB2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3QRX1> , <https://identifiers.org/uniprot/J3QLU9> , <https://identifiers.org/uniprot/J3QRJ7> , <https://identifiers.org/uniprot/J3KTI5> , <https://identifiers.org/uniprot/J3QLV2> , <https://identifiers.org/uniprot/X5DNK3> , <https://identifiers.org/uniprot/F5H1T4> , <https://identifiers.org/uniprot/B4DTR1> , <https://identifiers.org/uniprot/J3QL83> , <https://identifiers.org/uniprot/P04626> , <https://identifiers.org/uniprot/J3KRI9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14877486> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/d78f6> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f0aa9> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/J3QL83> , <http://purl.uniprot.org/uniprot/J3KTI5> , <http://purl.uniprot.org/uniprot/X5DNK3> , <http://purl.uniprot.org/uniprot/J3QRX1> , <http://purl.uniprot.org/uniprot/J3QLU9> , <http://purl.uniprot.org/uniprot/F5H1T4> , <http://purl.uniprot.org/uniprot/J3KRI9> , <http://purl.uniprot.org/uniprot/P04626> , <http://purl.uniprot.org/uniprot/B4DTR1> , <http://purl.uniprot.org/uniprot/J3QRJ7> , <http://purl.uniprot.org/uniprot/J3QLV2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000141736> .

<https://identifiers.org/ensembl/ENSG00000105221>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000105221> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000105221" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000105221> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/208> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/J3KT31> , <https://identifiers.org/uniprot/M0QZW8> , <https://identifiers.org/uniprot/M0R0P9> , <https://identifiers.org/uniprot/J3KSY8> , <https://identifiers.org/uniprot/J3KRI8> , <https://identifiers.org/uniprot/M0R283> , <https://identifiers.org/uniprot/E7EVP8> , <https://identifiers.org/uniprot/M0R275> , <https://identifiers.org/uniprot/J3QLS6> , <https://identifiers.org/uniprot/C9JC83> , <https://identifiers.org/uniprot/J3KTP4> , <https://identifiers.org/uniprot/A0A1B0GXA2> , <https://identifiers.org/uniprot/A0A5F9ZHJ8> , <https://identifiers.org/uniprot/J3QL45> , <https://identifiers.org/uniprot/M0QZK3> , <https://identifiers.org/uniprot/J3KTC6> , <https://identifiers.org/uniprot/A0A0A0MRF1> , <https://identifiers.org/uniprot/J3QKW1> , <https://identifiers.org/uniprot/C9J258> , <https://identifiers.org/uniprot/P31751> , <https://identifiers.org/uniprot/A8MX96> , <https://identifiers.org/uniprot/C9JHS6> , <https://identifiers.org/uniprot/C9JIF6> , <https://identifiers.org/uniprot/C9JIJ1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q4652205> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/d77b5> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/M0QZW8> , <http://purl.uniprot.org/uniprot/M0R0P9> , <http://purl.uniprot.org/uniprot/J3QL45> , <http://purl.uniprot.org/uniprot/J3QLS6> , <http://purl.uniprot.org/uniprot/C9JIJ1> , <http://purl.uniprot.org/uniprot/A0A5F9ZHJ8> , <http://purl.uniprot.org/uniprot/J3KRI8> , <http://purl.uniprot.org/uniprot/C9JC83> , <http://purl.uniprot.org/uniprot/M0R283> , <http://purl.uniprot.org/uniprot/A0A1B0GXA2> , <http://purl.uniprot.org/uniprot/P31751> , <http://purl.uniprot.org/uniprot/C9JIF6> , <http://purl.uniprot.org/uniprot/M0R275> , <http://purl.uniprot.org/uniprot/J3KT31> , <http://purl.uniprot.org/uniprot/M0QZK3> , <http://purl.uniprot.org/uniprot/C9JHS6> , <http://purl.uniprot.org/uniprot/J3KSY8> , <http://purl.uniprot.org/uniprot/J3KTC6> , <http://purl.uniprot.org/uniprot/C9J258> , <http://purl.uniprot.org/uniprot/J3QKW1> , <http://purl.uniprot.org/uniprot/A8MX96> , <http://purl.uniprot.org/uniprot/A0A0A0MRF1> , <http://purl.uniprot.org/uniprot/E7EVP8> , <http://purl.uniprot.org/uniprot/J3KTP4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000105221> .

<https://identifiers.org/drugbank/DB06366>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Pertuzumab" ;
        dc:identifier       <https://identifiers.org/drugbank/DB06366> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB06366" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q1998021> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/d3871> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB06366> .

<https://identifiers.org/ensembl/ENSG00000174775>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "HRAS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000174775> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000174775" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000174775> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3265> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/HRAS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01112> , <https://identifiers.org/uniprot/A0A804HJ06> , <https://identifiers.org/uniprot/X5D945> , <https://identifiers.org/uniprot/A0A804HKM6> , <https://identifiers.org/uniprot/A0A8C8MQR2> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/b2029> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/X5D945> , <http://purl.uniprot.org/uniprot/P01112> , <http://purl.uniprot.org/uniprot/A0A804HJ06> , <http://purl.uniprot.org/uniprot/A0A804HKM6> , <http://purl.uniprot.org/uniprot/A0A8C8MQR2> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000174775> .

<https://identifiers.org/drugbank/DB00072>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Trastuzumab" ;
        dc:identifier       <https://identifiers.org/drugbank/DB00072> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB00072" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q412616> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/bfb25> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB00072> .

<https://identifiers.org/ensembl/ENSG00000171608>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3CD" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000171608> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000171608" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000171608> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5293> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3CD> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/B7ZM44> , <https://identifiers.org/uniprot/A0A8V8TNP1> , <https://identifiers.org/uniprot/O00329> , <https://identifiers.org/uniprot/A0A8V8TMM0> , <https://identifiers.org/uniprot/A0A8V8TM62> , <https://identifiers.org/uniprot/A0A8V8TNW9> , <https://identifiers.org/uniprot/A0A2K8FKV1> , <https://identifiers.org/uniprot/F8W9P4> , <https://identifiers.org/uniprot/A0A8V8TML5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14887732> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f48cd> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8V8TNW9> , <http://purl.uniprot.org/uniprot/A0A8V8TMM0> , <http://purl.uniprot.org/uniprot/B7ZM44> , <http://purl.uniprot.org/uniprot/O00329> , <http://purl.uniprot.org/uniprot/A0A8V8TM62> , <http://purl.uniprot.org/uniprot/F8W9P4> , <http://purl.uniprot.org/uniprot/A0A8V8TNP1> , <http://purl.uniprot.org/uniprot/A0A2K8FKV1> , <http://purl.uniprot.org/uniprot/A0A8V8TML5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000171608> .

<https://identifiers.org/chebi/CHEBI:23965>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Estradiol" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/VOXZDWNPVJITMN-WKUFJEKOSA-N> ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:23965> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:23965" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idbcd6a84e> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/b006d> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/a2cbc> , <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/ec38f> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:23965> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/7987537> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/VOXZDWNPVJITMN-WKUFJEKOSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9811784> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q12415847> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e523e> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ec137> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:23965> .

<https://identifiers.org/ensembl/ENSG00000133056>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3C2B" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000133056> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000133056" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000133056> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5287> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3C2B> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/O00750> , <https://identifiers.org/uniprot/Q5SWA0> , <https://identifiers.org/uniprot/F5GWN5> , <https://identifiers.org/uniprot/A2RUF7> , <https://identifiers.org/uniprot/Q5SW97> , <https://identifiers.org/uniprot/Q5SW98> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030546> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ce649> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/O00750> , <http://purl.uniprot.org/uniprot/Q5SWA0> , <http://purl.uniprot.org/uniprot/Q5SW98> , <http://purl.uniprot.org/uniprot/Q5SW97> , <http://purl.uniprot.org/uniprot/A2RUF7> , <http://purl.uniprot.org/uniprot/F5GWN5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000133056> .

<https://identifiers.org/ensembl/ENSG00000129652>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "MAP2K6" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000129652> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000129652" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000129652> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a89ed> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000129652> .

<https://identifiers.org/drugbank/DB05773>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Trastuzumab emtansine" ;
        dc:identifier       <https://identifiers.org/drugbank/DB05773> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB05773" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q3997863> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a526f> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB05773> .

<https://identifiers.org/ensembl/ENSG00000141564>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "RPTOR" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000141564> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000141564" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/ee192> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000141564> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/57521> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RPTOR> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8V8TMD9> , <https://identifiers.org/uniprot/I3L2I3> , <https://identifiers.org/uniprot/I3L436> , <https://identifiers.org/uniprot/Q8N122> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18043110> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a1422> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q8N122> , <http://purl.uniprot.org/uniprot/I3L2I3> , <http://purl.uniprot.org/uniprot/I3L436> , <http://purl.uniprot.org/uniprot/A0A8V8TMD9> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000141564> .

<https://identifiers.org/ensembl/ENSG00000142208>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "AKT1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000142208> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000142208" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000142208> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/207> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/G3V2I6> , <https://identifiers.org/uniprot/A0A804HJM6> , <https://identifiers.org/uniprot/A0A087WY56> , <https://identifiers.org/uniprot/G3V3X1> , <https://identifiers.org/uniprot/B0LPE5> , <https://identifiers.org/uniprot/P31749> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q17816452> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f29ad> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/G3V3X1> , <http://purl.uniprot.org/uniprot/G3V2I6> , <http://purl.uniprot.org/uniprot/A0A087WY56> , <http://purl.uniprot.org/uniprot/P31749> , <http://purl.uniprot.org/uniprot/A0A804HJM6> , <http://purl.uniprot.org/uniprot/B0LPE5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000142208> .

<https://identifiers.org/ensembl/ENSG00000254647>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "INS" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000254647> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000254647" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/f7f26> , <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000254647> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3630> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/INS> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P01308> , <https://identifiers.org/uniprot/I3WAC9> , <https://identifiers.org/uniprot/A6XGL2> , <https://identifiers.org/uniprot/C9JNR5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q21163221> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c129d> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P01308> , <http://purl.uniprot.org/uniprot/A6XGL2> , <http://purl.uniprot.org/uniprot/I3WAC9> , <http://purl.uniprot.org/uniprot/C9JNR5> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000254647> .

<https://identifiers.org/ensembl/ENSG00000110092>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CCND1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000110092> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000110092" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/f5215> , <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/e0d74> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000110092> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CCND1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5H437> , <https://identifiers.org/uniprot/P24385> , <https://identifiers.org/uniprot/Q6FI00> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15311861> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/f756c> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a539e> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/Q6FI00> , <http://purl.uniprot.org/uniprot/P24385> , <http://purl.uniprot.org/uniprot/F5H437> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000110092> .

<https://identifiers.org/ensembl/ENSG00000117020>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "AKT3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000117020> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000117020" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000117020> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/10000> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/AKT3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A5F9ZGY0> , <https://identifiers.org/uniprot/A0A5F9ZHU3> , <https://identifiers.org/uniprot/A0A5K1VW74> , <https://identifiers.org/uniprot/A0A5F9ZGZ4> , <https://identifiers.org/uniprot/A0A7P0T872> , <https://identifiers.org/uniprot/A0A5F9ZHA9> , <https://identifiers.org/uniprot/A0A7P0T8T9> , <https://identifiers.org/uniprot/A0A7P0TBJ6> , <https://identifiers.org/uniprot/A0A7P0TB29> , <https://identifiers.org/uniprot/Q9Y243> , <https://identifiers.org/uniprot/A0A7P0TB32> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18034943> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a0979> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A5F9ZHU3> , <http://purl.uniprot.org/uniprot/Q9Y243> , <http://purl.uniprot.org/uniprot/A0A5K1VW74> , <http://purl.uniprot.org/uniprot/A0A5F9ZGY0> , <http://purl.uniprot.org/uniprot/A0A5F9ZHA9> , <http://purl.uniprot.org/uniprot/A0A7P0TBJ6> , <http://purl.uniprot.org/uniprot/A0A7P0TB32> , <http://purl.uniprot.org/uniprot/A0A5F9ZGZ4> , <http://purl.uniprot.org/uniprot/A0A7P0TB29> , <http://purl.uniprot.org/uniprot/A0A7P0T8T9> , <http://purl.uniprot.org/uniprot/A0A7P0T872> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000117020> .

<https://identifiers.org/drugbank/DBCAT005740>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "MEKi" ;
        dc:identifier       <https://identifiers.org/drugbank/DBCAT005740> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DBCAT005740" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ce300> ;
        foaf:page           <http://www.drugbank.ca/drugs/DBCAT005740> .

<https://identifiers.org/ensembl/ENSG00000135446>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "CDK4" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000135446> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000135446" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/f5215> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000135446> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1019> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDK4> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/Q96BE9> , <https://identifiers.org/uniprot/F8VYY1> , <https://identifiers.org/uniprot/F8VTV8> , <https://identifiers.org/uniprot/F8VZ51> , <https://identifiers.org/uniprot/F8VWX7> , <https://identifiers.org/uniprot/P11802> , <https://identifiers.org/uniprot/F8VYH9> , <https://identifiers.org/uniprot/F8W1L8> , <https://identifiers.org/uniprot/F8VZ13> , <https://identifiers.org/uniprot/F8VZZ0> , <https://identifiers.org/uniprot/F8VXD2> , <https://identifiers.org/uniprot/A0A024RBB6> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911754> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c9e81> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/F8VZ51> , <http://purl.uniprot.org/uniprot/F8W1L8> , <http://purl.uniprot.org/uniprot/F8VYH9> , <http://purl.uniprot.org/uniprot/F8VYY1> , <http://purl.uniprot.org/uniprot/F8VTV8> , <http://purl.uniprot.org/uniprot/F8VWX7> , <http://purl.uniprot.org/uniprot/Q96BE9> , <http://purl.uniprot.org/uniprot/P11802> , <http://purl.uniprot.org/uniprot/F8VZ13> , <http://purl.uniprot.org/uniprot/F8VZZ0> , <http://purl.uniprot.org/uniprot/F8VXD2> , <http://purl.uniprot.org/uniprot/A0A024RBB6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000135446> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/f5215>
        rdf:type          wp:Complex , wp:DataNode ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/f5215> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000135446> , <https://identifiers.org/ensembl/ENSG00000110092> .

<https://identifiers.org/ensembl/ENSG00000139144>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "PIK3C2G" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000139144> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000139144" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000139144> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5288> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/PIK3C2G> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/F5GWG6> , <https://identifiers.org/uniprot/A0A087WV31> , <https://identifiers.org/uniprot/F5H369> , <https://identifiers.org/uniprot/O75747> , <https://identifiers.org/uniprot/F5H7Y7> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q18030547> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c41f4> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A087WV31> , <http://purl.uniprot.org/uniprot/F5H7Y7> , <http://purl.uniprot.org/uniprot/F5GWG6> , <http://purl.uniprot.org/uniprot/F5H369> , <http://purl.uniprot.org/uniprot/O75747> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000139144> .

<https://identifiers.org/drugbank/DB00990>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Exemestane" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/BFYIZQONLCFLEV-DAELLWKTSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB00990> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB00990" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:4953> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/54278> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0015125> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/BFYIZQONLCFLEV-DAELLWKTSA-N> ;
        wp:bdbKeggCompound  <https://identifiers.org/kegg.compound/C08162> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID60198> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q418819> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e5c44> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB00990> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/f7f26>
        rdf:type          wp:Binding , wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/f7f26> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000140443> , <https://identifiers.org/ensembl/ENSG00000254647> ;
        wp:source         <https://identifiers.org/ensembl/ENSG00000254647> ;
        wp:target         <https://identifiers.org/ensembl/ENSG00000140443> .

<https://identifiers.org/drugbank/DB01590>
        rdf:type            wp:DataNode , wp:Metabolite ;
        rdfs:label          "Everolimus" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/HKVAMNSJSFKALM-GKUWKFKPSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB01590> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB01590" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:68478> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/21106307> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0015529> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/HKVAMNSJSFKALM-GKUWKFKPSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6442177> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q421052> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c3f24> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB01590> .

<https://identifiers.org/drugbank/DB00947>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Fulvestrant" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/VWUXBMIQPBEWFH-WCCTWKNTSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB00947> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB00947" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/ec38f> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:31638> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/94553> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/VWUXBMIQPBEWFH-WCCTWKNTSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID104741> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q5508491> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c8e12> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB00947> .

<https://identifiers.org/ensembl/ENSG00000102882>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "MAPK3" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000102882> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000102882" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000102882> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5595> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/MAPK3> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/H0YEX6> , <https://identifiers.org/uniprot/E9PBK7> , <https://identifiers.org/uniprot/L7RXH5> , <https://identifiers.org/uniprot/B3KR49> , <https://identifiers.org/uniprot/P27361> , <https://identifiers.org/uniprot/H0YDH9> , <https://identifiers.org/uniprot/E9PRH7> , <https://identifiers.org/uniprot/E9PQW4> , <https://identifiers.org/uniprot/E9PJF0> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q15328839> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/eb802> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E9PQW4> , <http://purl.uniprot.org/uniprot/L7RXH5> , <http://purl.uniprot.org/uniprot/H0YEX6> , <http://purl.uniprot.org/uniprot/H0YDH9> , <http://purl.uniprot.org/uniprot/E9PJF0> , <http://purl.uniprot.org/uniprot/E9PBK7> , <http://purl.uniprot.org/uniprot/P27361> , <http://purl.uniprot.org/uniprot/B3KR49> , <http://purl.uniprot.org/uniprot/E9PRH7> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000102882> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/ComplexBinding/ee192>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/ee192> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000198793> , <https://identifiers.org/ensembl/ENSG00000141564> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/ee192> .

<https://identifiers.org/chebi/CHEBI:50113>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Androgen" ;
        dc:identifier       <https://identifiers.org/chebi/CHEBI:50113> ;
        dc:source           "ChEBI" ;
        dcterms:identifier  "CHEBI:50113" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idbcd6a84e> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:50113> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q62614> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/ebbde> ;
        foaf:page           <https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50113> .

<https://identifiers.org/drugbank/DB00675>
        rdf:type            wp:Metabolite , wp:DataNode ;
        rdfs:label          "Tamoxifen" ;
        rdfs:seeAlso        <https://identifiers.org/inchikey/NKANXQFJJICGDU-QPLCGJKRSA-N> ;
        dc:identifier       <https://identifiers.org/drugbank/DB00675> ;
        dc:source           "DrugBank" ;
        dcterms:identifier  "DB00675" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbChEBI         <https://identifiers.org/chebi/CHEBI:41774> ;
        wp:bdbChemspider    <https://identifiers.org/chemspider/2015313> ;
        wp:bdbHmdb          <https://identifiers.org/hmdb/HMDB0014813> ;
        wp:bdbInChIKey      <https://identifiers.org/inchikey/NKANXQFJJICGDU-QPLCGJKRSA-N> ;
        wp:bdbPubChem       <http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID2733526> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q412178> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/fea91> ;
        foaf:page           <http://www.drugbank.ca/drugs/DB00675> .

<https://identifiers.org/ensembl/ENSG00000140443>
        rdf:type            wp:DataNode , wp:GeneProduct ;
        rdfs:label          "IGF1R" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000140443> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000140443" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/f7f26> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idba62686d> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000140443> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/3480> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/IGF1R> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/P08069> , <https://identifiers.org/uniprot/H0YMJ5> , <https://identifiers.org/uniprot/H3BSZ8> , <https://identifiers.org/uniprot/H0YNR0> , <https://identifiers.org/uniprot/C9J5X1> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14901457> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/e9791> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/P08069> , <http://purl.uniprot.org/uniprot/H3BSZ8> , <http://purl.uniprot.org/uniprot/H0YMJ5> , <http://purl.uniprot.org/uniprot/H0YNR0> , <http://purl.uniprot.org/uniprot/C9J5X1> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000140443> .

<https://identifiers.org/ensembl/ENSG00000132155>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "RAF1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000132155> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000132155" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000132155> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/5894> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/RAF1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A8I5KSM4> , <https://identifiers.org/uniprot/A0A8I5KWS9> , <https://identifiers.org/uniprot/A0A8I5KQV4> , <https://identifiers.org/uniprot/A0A8I5KSB0> , <https://identifiers.org/uniprot/A0A8I5KTK4> , <https://identifiers.org/uniprot/A0A8I5KSV6> , <https://identifiers.org/uniprot/P04049> , <https://identifiers.org/uniprot/H7C155> , <https://identifiers.org/uniprot/A0A8I5KYC4> , <https://identifiers.org/uniprot/A0A8I5KR46> , <https://identifiers.org/uniprot/A0A8I5KWA9> , <https://identifiers.org/uniprot/A0A8I5QJG5> , <https://identifiers.org/uniprot/A0A8I5KS16> , <https://identifiers.org/uniprot/A0A8I5KSI1> , <https://identifiers.org/uniprot/A0A8I5KTA5> , <https://identifiers.org/uniprot/A0A0B4J1W9> , <https://identifiers.org/uniprot/A0A8I5QKZ6> , <https://identifiers.org/uniprot/A0A8I5KW44> , <https://identifiers.org/uniprot/A0A8I5KRD1> , <https://identifiers.org/uniprot/A0A8I5QKU8> , <https://identifiers.org/uniprot/L7RRS6> , <https://identifiers.org/uniprot/A0A8I5KQ33> , <https://identifiers.org/uniprot/A0A0S2Z559> , <https://identifiers.org/uniprot/A0A8I5KYP5> , <https://identifiers.org/uniprot/A0A8I5KWF7> , <https://identifiers.org/uniprot/A0A8I5KUW4> , <https://identifiers.org/uniprot/A0A8I5KT32> , <https://identifiers.org/uniprot/A0A8I5KX50> , <https://identifiers.org/uniprot/A0A0S2Z4L5> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14903573> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c9fbf> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A8I5KTK4> , <http://purl.uniprot.org/uniprot/A0A8I5KQ33> , <http://purl.uniprot.org/uniprot/A0A8I5QKZ6> , <http://purl.uniprot.org/uniprot/A0A8I5KYP5> , <http://purl.uniprot.org/uniprot/H7C155> , <http://purl.uniprot.org/uniprot/A0A8I5KSI1> , <http://purl.uniprot.org/uniprot/A0A8I5KWA9> , <http://purl.uniprot.org/uniprot/A0A0S2Z559> , <http://purl.uniprot.org/uniprot/A0A8I5KSM4> , <http://purl.uniprot.org/uniprot/A0A8I5KSV6> , <http://purl.uniprot.org/uniprot/A0A8I5KWF7> , <http://purl.uniprot.org/uniprot/A0A8I5KUW4> , <http://purl.uniprot.org/uniprot/A0A8I5QJG5> , <http://purl.uniprot.org/uniprot/A0A0S2Z4L5> , <http://purl.uniprot.org/uniprot/A0A0B4J1W9> , <http://purl.uniprot.org/uniprot/L7RRS6> , <http://purl.uniprot.org/uniprot/A0A8I5KYC4> , <http://purl.uniprot.org/uniprot/A0A8I5KS16> , <http://purl.uniprot.org/uniprot/P04049> , <http://purl.uniprot.org/uniprot/A0A8I5KTA5> , <http://purl.uniprot.org/uniprot/A0A8I5KRD1> , <http://purl.uniprot.org/uniprot/A0A8I5KT32> , <http://purl.uniprot.org/uniprot/A0A8I5QKU8> , <http://purl.uniprot.org/uniprot/A0A8I5KWS9> , <http://purl.uniprot.org/uniprot/A0A8I5KSB0> , <http://purl.uniprot.org/uniprot/A0A8I5KR46> , <http://purl.uniprot.org/uniprot/A0A8I5KX50> , <http://purl.uniprot.org/uniprot/A0A8I5KW44> , <http://purl.uniprot.org/uniprot/A0A8I5KQV4> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000132155> .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/a2cbc>
        rdf:type          wp:DirectedInteraction , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Interaction/a2cbc> ;
        wp:participants   <https://identifiers.org/chebi/CHEBI:23965> ;
        wp:source         <https://identifiers.org/chebi/CHEBI:23965> ;
        wp:target         <https://identifiers.org/chebi/CHEBI:23965> .

<https://identifiers.org/ensembl/ENSG00000123374>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CDK2" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000123374> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000123374" ;
        dcterms:isPartOf    <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/fef50> , <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000123374> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1017> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CDK2> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/A0A024RB77> , <https://identifiers.org/uniprot/G3V317> , <https://identifiers.org/uniprot/P24941> , <https://identifiers.org/uniprot/A0A024RB10> , <https://identifiers.org/uniprot/E7ESI2> , <https://identifiers.org/uniprot/G3V5T9> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14911732> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/a7cd6> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/A0A024RB10> , <http://purl.uniprot.org/uniprot/G3V5T9> , <http://purl.uniprot.org/uniprot/E7ESI2> , <http://purl.uniprot.org/uniprot/G3V317> , <http://purl.uniprot.org/uniprot/P24941> , <http://purl.uniprot.org/uniprot/A0A024RB77> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000123374> .

<https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP5497&oldid=142315>
        rdf:type        foaf:Image ;
        dcterms:format  "image/png" .

<http://rdf.wikipathways.org/Pathway/WP5497_r142315/ComplexBinding/e0d74>
        rdf:type          wp:ComplexBinding , wp:Binding , wp:Interaction ;
        dcterms:isPartOf  <https://identifiers.org/wikipathways/WP5497_r142315> ;
        wp:isAbout        <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Group/e0d74> ;
        wp:participants   <https://identifiers.org/ensembl/ENSG00000110092> , <https://identifiers.org/ensembl/ENSG00000105810> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/Complex/e0d74> .

<https://identifiers.org/ensembl/ENSG00000137869>
        rdf:type            wp:GeneProduct , wp:DataNode ;
        rdfs:label          "CYP19A1" ;
        dc:identifier       <https://identifiers.org/ensembl/ENSG00000137869> ;
        dc:source           "Ensembl" ;
        dcterms:identifier  "ENSG00000137869" ;
        dcterms:isPartOf    <https://identifiers.org/wikipathways/WP5497_r142315> , <http://rdf.wikipathways.org/Pathway/WP5497_r142315/WP/Interaction/idf1a1fb9f> ;
        wp:bdbEnsembl       <https://identifiers.org/ensembl/ENSG00000137869> ;
        wp:bdbEntrezGene    <https://identifiers.org/ncbigene/1588> ;
        wp:bdbHgncSymbol    <https://identifiers.org/hgnc.symbol/CYP19A1> ;
        wp:bdbUniprot       <https://identifiers.org/uniprot/E9PGZ6> , <https://identifiers.org/uniprot/H0YKN1> , <https://identifiers.org/uniprot/H0YK57> , <https://identifiers.org/uniprot/A0A024R5S8> , <https://identifiers.org/uniprot/E7EQ08> , <https://identifiers.org/uniprot/H0YLS2> , <https://identifiers.org/uniprot/H0YLP1> , <https://identifiers.org/uniprot/E7EPL6> , <https://identifiers.org/uniprot/H0YNJ7> , <https://identifiers.org/uniprot/P11511> ;
        wp:bdbWikidata      <http://www.wikidata.org/entity/Q14865015> ;
        wp:isAbout          <http://rdf.wikipathways.org/Pathway/WP5497_r142315/DataNode/c2660> ;
        owl:sameAs          <http://purl.uniprot.org/uniprot/E7EPL6> , <http://purl.uniprot.org/uniprot/P11511> , <http://purl.uniprot.org/uniprot/H0YLS2> , <http://purl.uniprot.org/uniprot/H0YNJ7> , <http://purl.uniprot.org/uniprot/E7EQ08> , <http://purl.uniprot.org/uniprot/H0YKN1> , <http://purl.uniprot.org/uniprot/H0YLP1> , <http://purl.uniprot.org/uniprot/H0YK57> , <http://purl.uniprot.org/uniprot/A0A024R5S8> , <http://purl.uniprot.org/uniprot/E9PGZ6> ;
        foaf:page           <https://www.ensembl.org/id/ENSG00000137869> .
