<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Glutathione and one-carbon metabolism" Data-Source="WikiPathways" Version="WP730_r137053" Author="[Thomas, Lbrenn, MaintBot, Mkutmon, Egonw, AlexanderPico, L Dupuis, NhungP, Eweitz, Khanspers]" Last-Modified="20250226223255" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway provides a combined view on the one-carbon and glutathione metabolism pathways.

Based on existing pathways:[WP435](https://www.wikipathways.org/pathways/WP435.html),[WP164](https://www.wikipathways.org/pathways/WP164.html)</Comment>
  <Graphics BoardWidth="1366.9999999999998" BoardHeight="1730.6666666666667" />
  <DataNode TextLabel="5-Methyl Tetrahydrofolate" GraphId="a1240" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="642.4916666666667" CenterY="543.5" Width="129.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="134-35-0" />
  </DataNode>
  <DataNode TextLabel="ANPEP" GraphId="a2d11" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ANPEP | alanyl (membrane) aminopeptidase (amino..." />
    <Graphics CenterX="620.0" CenterY="1178.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16790" />
  </DataNode>
  <DataNode TextLabel="G6PD" GraphId="a3362" Type="GeneProduct" GroupRef="f3c18">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="G6PD | glucose-6-phosphate dehydrogenase" />
    <Graphics CenterX="340.6666666666667" CenterY="1509.3333333333333" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14381" />
  </DataNode>
  <DataNode TextLabel="1.11.1.12" GraphId="a369a" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="277.3333333333333" CenterY="1651.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.11.1.12" />
  </DataNode>
  <DataNode TextLabel="Cysteinyl-glycine" GraphId="a3a02" Type="Metabolite">
    <Graphics CenterX="580.0" CenterY="1263.0" Width="108.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C01419" />
  </DataNode>
  <DataNode TextLabel="GGTLA1" GraphId="a5275" Type="GeneProduct" GroupRef="a04cf">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GGTLA1 | gamma-glutamyltransferase-like activit..." />
    <Graphics CenterX="582.0" CenterY="1351.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="23887" />
  </DataNode>
  <DataNode TextLabel="Homocysteine" GraphId="a5e38" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="1063.4916666666666" CenterY="550.5" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="6027-13-0" />
  </DataNode>
  <DataNode TextLabel="GPX1" GraphId="a735d" Type="GeneProduct" GroupRef="aa71d">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GPX1 | glutathione peroxidase 1" />
    <Graphics CenterX="407.3333333333333" CenterY="1611.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14775" />
  </DataNode>
  <DataNode TextLabel="Oxidized glutathione" GraphId="a778f" Type="Metabolite">
    <Graphics CenterX="226.0" CenterY="1407.0" Width="116.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C00127" />
  </DataNode>
  <DataNode TextLabel="BHMT" GraphId="ab980" Type="GeneProduct">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="894.825" CenterY="274.3333333333333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12116" />
  </DataNode>
  <DataNode TextLabel="1.8.4.2" GraphId="ad310" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="277.3333333333333" CenterY="1611.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.4.2" />
  </DataNode>
  <DataNode TextLabel="L-Amino acid" GraphId="ad3c8" Type="Metabolite">
    <Graphics CenterX="376.0" CenterY="870.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C00151" />
  </DataNode>
  <DataNode TextLabel="DNMT1" GraphId="aebbb" Type="GeneProduct" GroupRef="c455b">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="1188.0" CenterY="406.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13433" />
  </DataNode>
  <DataNode TextLabel="betaine aldehyde" GraphId="aef92" Type="Metabolite">
    <Graphics CenterX="935.5" CenterY="152.0" Width="100.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Methionine" GraphId="af18d" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="1072.4916666666666" CenterY="274.5" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="63-68-3" />
  </DataNode>
  <DataNode TextLabel="NADPH" GraphId="afd66" Type="Metabolite">
    <Graphics CenterX="264.0" CenterY="1454.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000221" />
  </DataNode>
  <DataNode TextLabel="S-adenosylhomocysteine" GraphId="b1bfe" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="1255.9916666666666" CenterY="494.5" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="979-92-0" />
  </DataNode>
  <DataNode TextLabel="Betaine" GraphId="b28b8" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="924.825" CenterY="222.83333333333334" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="107-43-7" />
  </DataNode>
  <DataNode TextLabel="MTRR" GraphId="b3059" Type="GeneProduct" GroupRef="bdb05">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="925.0" CenterY="383.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="210009" />
  </DataNode>
  <DataNode TextLabel="L-Cysteine" GraphId="b4e2e" Type="Metabolite">
    <Graphics CenterX="707.0" CenterY="1067.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C00097" />
  </DataNode>
  <DataNode TextLabel="MTHFR" GraphId="b5b6c" Type="GeneProduct">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="286.0" CenterY="530.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="17769" />
  </DataNode>
  <DataNode TextLabel="2.3.2.4" GraphId="b84c2" Type="GeneProduct">
    <Graphics CenterX="368.3333333333333" CenterY="967.3333333333334" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="2.3.2.4" />
  </DataNode>
  <DataNode TextLabel="NADP+" GraphId="b9251" Type="Metabolite">
    <Graphics CenterX="423.0" CenterY="1458.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000217" />
  </DataNode>
  <DataNode TextLabel="L-Glutamate" GraphId="bbba8" Type="Metabolite">
    <Graphics CenterX="880.0" CenterY="947.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C00025" />
  </DataNode>
  <DataNode TextLabel="cystathionine" GraphId="bcf26" Type="Metabolite">
    <Graphics CenterX="996.0" CenterY="675.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="GCLM" GraphId="bfb9b" Type="GeneProduct" GroupRef="a4bbd">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GCLM | glutamate-cysteine ligase modifier subu..." />
    <Graphics CenterX="900.3333333333334" CenterY="1157.3333333333333" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14630" />
  </DataNode>
  <DataNode TextLabel="GSR" GraphId="c0e28" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GSR | glutathione reductase" />
    <Graphics CenterX="346.6666666666667" CenterY="1407.3333333333333" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14782" />
  </DataNode>
  <DataNode TextLabel="1.8.4.4" GraphId="c3753" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="340.6666666666667" CenterY="1671.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.4.4" />
  </DataNode>
  <DataNode TextLabel="GGT1" GraphId="c4568" Type="GeneProduct" GroupRef="a04cf">
    <Comment Source="GenMAPP remarks">(5-L-Glutamyl)-L-amino acid</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GGT1 | gamma-glutamyltransferase 1" />
    <Graphics CenterX="582.0" CenterY="1331.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14598" />
  </DataNode>
  <DataNode TextLabel="(5-L-Glutamyl)-L-amino acid" GraphId="c5a77" Type="Metabolite">
    <Graphics CenterX="355.0" CenterY="1146.0" Width="160.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C03740" />
  </DataNode>
  <DataNode TextLabel="GSS" GraphId="c7737" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GSS | glutathione synthetase" />
    <Graphics CenterX="734.6666666666666" CenterY="1410.0" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14854" />
  </DataNode>
  <DataNode TextLabel="GCLC" GraphId="c90f5" Type="GeneProduct" GroupRef="a4bbd">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GCLC | glutamate-cysteine ligase catalytic sub..." />
    <Graphics CenterX="900.3333333333334" CenterY="1137.3333333333333" Width="50.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14629" />
  </DataNode>
  <DataNode TextLabel="AMT" GraphId="caadc" Type="GeneProduct" GroupRef="c0264">
    <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment>
    <Graphics CenterX="302.6666666666667" CenterY="349.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="434437" />
  </DataNode>
  <DataNode TextLabel="KIAA0828" GraphId="cbc98" Type="GeneProduct" GroupRef="ddad8">
    <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment>
    <Graphics CenterX="1191.0" CenterY="605.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="74340" />
  </DataNode>
  <DataNode TextLabel="MTR" GraphId="cbd96" Type="GeneProduct" GroupRef="bdb05">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="925.0" CenterY="403.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="238505" />
  </DataNode>
  <DataNode TextLabel="MAT2B" GraphId="d5f10" Type="GeneProduct" GroupRef="e90bc">
    <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment>
    <Graphics CenterX="1149.0" CenterY="228.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="108645" />
  </DataNode>
  <DataNode TextLabel="3.4.11.4" GraphId="d92ee" Type="GeneProduct" GroupRef="a04cf">
    <Graphics CenterX="582.0" CenterY="1311.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="3.4.11.4" />
  </DataNode>
  <DataNode TextLabel="1.8.4.7" GraphId="d94f4" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="277.3333333333333" CenterY="1631.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.4.7" />
  </DataNode>
  <DataNode TextLabel="1.8.3.3" GraphId="d9907" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="277.3333333333333" CenterY="1671.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.3.3" />
  </DataNode>
  <DataNode TextLabel="Glycine" GraphId="dabb1" Type="Metabolite">
    <Graphics CenterX="736.0" CenterY="1220.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000123" />
  </DataNode>
  <DataNode TextLabel="1.8.5.1" GraphId="dc4c8" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="340.6666666666667" CenterY="1611.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.5.1" />
  </DataNode>
  <DataNode TextLabel="DNMT3a" GraphId="de84a" Type="GeneProduct" GroupRef="c455b">
    <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment>
    <Graphics CenterX="1188.0" CenterY="426.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13435" />
  </DataNode>
  <DataNode TextLabel="2.8.1.3" GraphId="e0be4" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="340.6666666666667" CenterY="1631.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="2.8.1.3" />
  </DataNode>
  <DataNode TextLabel="1.5.4.1" GraphId="e1b20" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="277.3333333333333" CenterY="1591.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.5.4.1" />
  </DataNode>
  <DataNode TextLabel="Chdh" GraphId="e24cb" Type="GeneProduct">
    <Graphics CenterX="1022.6666666666666" CenterY="111.33333333333333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="218865" />
  </DataNode>
  <DataNode TextLabel="Glutathione (reduced)" GraphId="e2b01" Type="Metabolite">
    <Graphics CenterX="580.0" CenterY="1410.0" Width="118.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C00051" />
  </DataNode>
  <DataNode TextLabel="GGT1" GraphId="e5487" Type="GeneProduct" GroupRef="df5aa">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GGT1 | gamma-glutamyltransferase 1" />
    <Graphics CenterX="424.3333333333333" CenterY="1268.6666666666667" Width="50.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14598" />
  </DataNode>
  <DataNode TextLabel="GPX2" GraphId="e605b" Type="GeneProduct" GroupRef="aa71d">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GPX2 | glutathione peroxidase 2 (gastrointestin..." />
    <Graphics CenterX="407.3333333333333" CenterY="1591.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14776" />
  </DataNode>
  <DataNode TextLabel="Choline" GraphId="e779b" Type="Metabolite">
    <Graphics CenterX="960.0" CenterY="61.0" Width="80.0" Height="28.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="GGTLA1" GraphId="e8709" Type="GeneProduct" GroupRef="df5aa">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GGTLA1 | gamma-glutamyltransferase-like activit..." />
    <Graphics CenterX="424.3333333333333" CenterY="1248.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="23887" />
  </DataNode>
  <DataNode TextLabel="Tetrahydrofolate" GraphId="e96d3" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="577.5" CenterY="300.8333333333333" Width="184.33333333333334" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="135-16-0" />
  </DataNode>
  <DataNode TextLabel="DNMT3b" GraphId="ebdfc" Type="GeneProduct" GroupRef="c455b">
    <Comment>KEGG database: Methionine metabolism - Homo sapiens (human)</Comment>
    <Graphics CenterX="1188.0" CenterY="446.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13436" />
  </DataNode>
  <DataNode TextLabel="1.8.4.1" GraphId="ed28a" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="340.6666666666667" CenterY="1651.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.4.1" />
  </DataNode>
  <DataNode TextLabel="1.8.4.3" GraphId="ed8d0" Type="GeneProduct" GroupRef="aa71d">
    <Graphics CenterX="340.6666666666667" CenterY="1591.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.8.4.3" />
  </DataNode>
  <DataNode TextLabel="g-L-Glutamyl-L-cysteine" GraphId="ede5a" Type="Metabolite">
    <Graphics CenterX="867.0" CenterY="1410.0" Width="132.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C00669" />
  </DataNode>
  <DataNode TextLabel="DMG" GraphId="f155a" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="884.1583333333333" CenterY="326.1666666666667" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="107-43-7" />
  </DataNode>
  <DataNode TextLabel="5,10-Methylene Tetrahydrofolate" GraphId="f22ba" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="393.9916666666667" CenterY="418.5" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="25513-46-6" />
  </DataNode>
  <DataNode TextLabel="MAT1A" GraphId="f4bda" Type="GeneProduct" GroupRef="e90bc">
    <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment>
    <Graphics CenterX="1149.0" CenterY="204.33333333333334" Width="80.0" Height="27.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11720" />
  </DataNode>
  <DataNode TextLabel="Oplah" GraphId="f5d99" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPLAH | 5-oxoprolinase (ATP-hydrolysing)" />
    <Graphics CenterX="639.0" CenterY="925.6666666666666" Width="53.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="75475" />
  </DataNode>
  <DataNode TextLabel="S-Adenosylmethionine" GraphId="f8e72" Type="Metabolite">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="1254.6583333333333" CenterY="363.5" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="29908-03-0" />
  </DataNode>
  <DataNode TextLabel="5-Oxoproline" GraphId="fb490" Type="Metabolite">
    <Graphics CenterX="473.0" CenterY="910.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="KEGG Compound" ID="C01879" />
  </DataNode>
  <DataNode TextLabel="1.1.1.43" GraphId="fcacf" Type="GeneProduct" GroupRef="f3c18">
    <Graphics CenterX="340.6666666666667" CenterY="1489.3333333333333" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="1.1.1.43" />
  </DataNode>
  <DataNode TextLabel="Chdh" GraphId="fcf44" Type="GeneProduct">
    <Graphics CenterX="982.0" CenterY="178.66666666666666" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="218865" />
  </DataNode>
  <DataNode TextLabel="IDH1" GraphId="fd5a9" Type="GeneProduct" GroupRef="f3c18">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IDH1 | isocitrate dehydrogenase 1 (NADP+) solu..." />
    <Graphics CenterX="340.6666666666667" CenterY="1469.3333333333333" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="15926" />
  </DataNode>
  <DataNode TextLabel="2.3.2.4" GraphId="fd783" Type="GeneProduct">
    <Graphics CenterX="748.6666666666666" CenterY="845.3333333333334" Width="46.666666666666664" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Enzyme Nomenclature" ID="2.3.2.4" />
  </DataNode>
  <DataNode TextLabel="AHCY" GraphId="fdf99" Type="GeneProduct" GroupRef="ddad8">
    <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment>
    <Graphics CenterX="1191.0" CenterY="585.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="269378" />
  </DataNode>
  <DataNode TextLabel="SHMT1" GraphId="fe35b" Type="GeneProduct" GroupRef="c0264">
    <BiopaxRef>cf5</BiopaxRef>
    <Graphics CenterX="302.6666666666667" CenterY="309.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20425" />
  </DataNode>
  <DataNode TextLabel="GPX3" GraphId="fe822" Type="GeneProduct" GroupRef="aa71d">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GPX3 | glutathione peroxidase 3 (plasma)" />
    <Graphics CenterX="407.3333333333333" CenterY="1651.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14778" />
  </DataNode>
  <DataNode TextLabel="SHMT2" GraphId="ff1f2" Type="GeneProduct" GroupRef="c0264">
    <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment>
    <Graphics CenterX="302.6666666666667" CenterY="329.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="108037" />
  </DataNode>
  <DataNode TextLabel="GPX4" GraphId="ff8d3" Type="GeneProduct" GroupRef="aa71d">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GPX4 | glutathione peroxidase 4 (phospholipid h..." />
    <Graphics CenterX="407.3333333333333" CenterY="1631.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="625249" />
  </DataNode>
  <DataNode TextLabel="CBS" GraphId="b71b4" Type="GeneProduct">
    <Graphics CenterX="1041.0" CenterY="603.0" Width="80.0" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12411" />
  </DataNode>
  <DataNode TextLabel="CTH" GraphId="f2f44" Type="GeneProduct">
    <Graphics CenterX="930.0" CenterY="781.0" Width="80.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="107869" />
  </DataNode>
  <Interaction GraphId="a26c1">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="945.0791666666667" Y="238.33333333333334" GraphRef="b28b8" RelX="0.5" RelY="1.0" />
      <Point X="924.6666666666666" Y="326.1666666666667" GraphRef="f155a" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2973">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="346.66666666666674" Y="1397.3333333333333" GraphRef="c0e28" RelX="0.0" RelY="-1.0" />
      <Point X="343.02851650112143" Y="1407.7471964114065" GraphRef="d4100" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2ee6">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="305.1666666666667" Y="1489.3333333333333" GraphRef="f86e8" RelX="-1.0" RelY="0.0" />
      <Point X="335.00000000000006" Y="1417.3333333333333" GraphRef="c0e28" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="be814" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a4633">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="336.0" Y="870.0" GraphRef="ad3c8" RelX="-1.0" RelY="0.0" />
      <Point X="234.0" Y="1066.5" />
      <Point X="526.0" Y="1263.0" GraphRef="a3a02" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.8500782172844236" Shape="None" GraphId="d0136" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a4b6c">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="748.6666666666665" Y="835.3333333333334" GraphRef="fd783" RelX="0.0" RelY="-1.0" />
      <Point X="747.251361659491" Y="798.0" GraphRef="deab2" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a7582">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="485.33333333333337" Y="300.8333333333333" GraphRef="e96d3" RelX="-1.0" RelY="0.0" />
      <Point X="353.4875" Y="403.0" GraphRef="f22ba" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.5234643676004206" Shape="None" GraphId="a28b2" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a99cb">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="996.0" Y="685.0" GraphRef="bcf26" RelX="0.0" RelY="1.0" />
      <Point X="727.0" Y="1057.0" GraphRef="b4e2e" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.2519348027236708" Shape="None" GraphId="b1641" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a9c2d">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="358.8188820213921" Y="524.3062254995335" GraphRef="f57af" RelX="0.0" RelY="0.0" />
      <Point X="326.0" Y="530.0" GraphRef="b5b6c" RelX="1.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="aef55">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="443.3333333333333" Y="1286.6666666666667" GraphRef="ed284" RelX="0.5" RelY="1.0" />
      <Point X="408.0115570028413" Y="1263.0" GraphRef="d0136" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="af2d1">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="639.0" Y="935.6666666666666" GraphRef="f5d99" RelX="0.0" RelY="1.0" />
      <Point X="643.8" Y="924.8" GraphRef="c2a80" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b0439">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="620.0" Y="1331.0" GraphRef="b41c4" RelX="1.0" RelY="0.0" />
      <Point X="580.0" Y="1325.0" GraphRef="c76e8" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b1471">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="1255.9916666666663" Y="510.0" GraphRef="b1bfe" RelX="0.0" RelY="1.0" />
      <Point X="1104.0" Y="550.5" GraphRef="a5e38" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.5429527605564718" Shape="None" GraphId="b536f" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b1fa8">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="622.3283677077195" Y="1183.375769004125" GraphRef="d52fc" RelX="0.0" RelY="0.0" />
      <Point X="696.0" Y="1220.0" GraphRef="dabb1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b2342">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="880.0017704544568" Y="376.4319910676186" GraphRef="ef04b" RelX="0.0" RelY="0.0" />
      <Point X="925.0" Y="421.0" GraphRef="fff61" RelX="0.0" RelY="1.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b2ed1">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="ff0000">
      <Point X="218.33333333333348" Y="1631.3333333333333" GraphRef="d685d" RelX="-1.0" RelY="0.0" />
      <Point X="197.0" Y="1417.0" GraphRef="a778f" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b3b34">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="391.66666666666674" Y="967.3333333333334" GraphRef="b84c2" RelX="1.0" RelY="0.0" />
      <Point X="368.81485972384314" Y="967.5902814617215" GraphRef="be74a" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b5389">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1142.32827680111" Y="275.7980845218996" GraphRef="f4e37" RelX="0.0" RelY="0.0" />
      <Point X="1149.0" Y="246.0" GraphRef="cacc9" RelX="0.0" RelY="1.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b6ce6">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="482.33333333333326" Y="340.0" GraphRef="de81d" RelX="-1.0" RelY="0.0" />
      <Point X="377.3333333333333" Y="354.66666666666663" />
      <Point X="474.33333333333326" Y="369.3333333333333" GraphRef="d7ca8" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b6d88">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="786.1666666666665" Y="1311.8333333333335" GraphRef="deafe" RelX="0.0" RelY="-1.0" />
      <Point X="756.0" Y="1230.0" GraphRef="dabb1" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="be4de">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="925.0" Y="421.0" GraphRef="fff61" RelX="0.0" RelY="1.0" />
      <Point X="928.6134336392358" Y="430.0330276878807" GraphRef="a85f4" RelX="0.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c0a17">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="376.1666666666667" Y="1489.3333333333333" GraphRef="f86e8" RelX="1.0" RelY="0.0" />
      <Point X="358.3333333333334" Y="1417.3333333333333" GraphRef="c0e28" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="d04e6" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c0b9c">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="667.0" Y="1067.0" GraphRef="b4e2e" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Point X="624.0" Y="1067.083333333333" GraphRef="b587d" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c1aee">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="645.9166666666665" Y="1008.5" GraphRef="e7d7e" RelX="0.0" RelY="1.0" />
      <Point X="687.0" Y="1057.0" GraphRef="b4e2e" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c2585">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="834.0" Y="1400.0" GraphRef="ede5a" RelX="-0.5" RelY="-1.0" />
      <Point X="663.5" Y="798.0" />
      <Point X="493.0" Y="900.0" GraphRef="fb490" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.6590896060674728" Shape="None" GraphId="deab2" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c2afa">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="900.0" Y="957.0" GraphRef="bbba8" RelX="0.5" RelY="1.0" />
      <Point X="900.0" Y="1400.0" GraphRef="ede5a" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.41986751592356686" Shape="None" GraphId="ef0e4" />
      <Anchor Position="0.31376975169300225" Shape="None" GraphId="b2123" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c8b3c">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="383.0" Y="1458.0" GraphRef="b9251" RelX="-1.0" RelY="0.0" />
      <Point X="395.77900591802165" Y="1458.6059927993776" GraphRef="d04e6" RelX="0.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c9b83">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="580.0" Y="1400.0" GraphRef="e2b01" RelX="0.0" RelY="-1.0" />
      <Point X="580.0" Y="1273.0" GraphRef="a3a02" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
      <Anchor Position="0.5905511811023622" Shape="None" GraphId="c76e8" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cae03">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1063.4916666666666" Y="566.0" GraphRef="a5e38" RelX="0.0" RelY="1.0" />
      <Point X="1016.0" Y="665.0" GraphRef="bcf26" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="b0ddf" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ce9ba">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="496.20000000000005" Y="1410.0" GraphRef="bdf99" RelX="-240.0" RelY="0.0" />
      <Point X="736.0" Y="1230.0" GraphRef="dabb1" RelX="0.0" RelY="1.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cea3f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="00ff00">
      <Point X="284.0" Y="1407.0" GraphRef="a778f" RelX="1.0" RelY="0.0" />
      <Point X="521.0" Y="1410.0" GraphRef="e2b01" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.24906547046886682" Shape="None" GraphId="d4100" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d15a7">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="900.0" Y="1096.0" GraphRef="b2123" RelX="0.0" RelY="0.0" />
      <Point X="747.0" Y="1067.0" GraphRef="b4e2e" RelX="1.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d2e34">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="734.6666666666665" Y="1400.0" GraphRef="c7737" RelX="0.0" RelY="-1.0" />
      <Point X="496.20000000000005" Y="1410.0" GraphRef="bdf99" RelX="-240.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d32f4">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="521.0" Y="1410.0" GraphRef="e2b01" RelX="-1.0" RelY="0.0" />
      <Point X="355.0" Y="1156.0" GraphRef="c5a77" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
      <Anchor Position="0.5320401424971761" Shape="None" GraphId="f7ae1" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d4d3d">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="355.0" Y="1136.0" GraphRef="c5a77" RelX="0.0" RelY="-1.0" />
      <Point X="376.0" Y="880.0" GraphRef="ad3c8" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
      <Anchor Position="0.6578504630401505" Shape="None" GraphId="be74a" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d61c7">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1179.306889169803" Y="545.5206931135126" GraphRef="b536f" RelX="0.0" RelY="0.0" />
      <Point X="1191.0" Y="567.0" GraphRef="ae9a7" RelX="0.0" RelY="-1.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d6389">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="748.6666666666665" Y="835.3333333333334" GraphRef="fd783" RelX="0.0" RelY="-1.0" />
      <Point X="765.8152478952293" Y="810.0" GraphRef="b7ea7" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d893a">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="962.0" Y="947.6666666666666" GraphRef="f82bf" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Point X="920.0" Y="947.0" GraphRef="bbba8" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d926f">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="933.3333333333334" Y="1147.3333333333333" GraphRef="c5445" RelX="1.0" RelY="0.0" />
      <Point X="900.0" Y="1143.00130955414" GraphRef="ef0e4" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d979e">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="580.0" Y="1253.0" GraphRef="a3a02" RelX="0.0" RelY="-1.0" />
      <Point X="687.0" Y="1077.0" GraphRef="b4e2e" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
      <Anchor Position="0.39559222156747187" Shape="None" GraphId="d52fc" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="da9ed">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="00ff00">
      <Point X="463.0" Y="1631.3333333333333" GraphRef="d685d" RelX="1.0" RelY="0.0" />
      <Point X="550.5" Y="1420.0" GraphRef="e2b01" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dc655">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="393.30548302977746" Y="326.9289488298288" GraphRef="a28b2" RelX="0.0" RelY="0.0" />
      <Point X="350.6666666666667" Y="329.0" GraphRef="c08a5" RelX="1.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dd9ae">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="609.5" Y="1400.0" GraphRef="e2b01" RelX="0.5" RelY="-1.0" />
      <Point X="860.0" Y="957.0" GraphRef="bbba8" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e28ef">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1254.6583333333333" Y="379.0" GraphRef="f8e72" RelX="0.0" RelY="1.0" />
      <Point X="1255.9916666666663" Y="479.0" GraphRef="b1bfe" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.63" Shape="None" GraphId="eacb0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e4bb1">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1255.4983333333332" Y="442.0" GraphRef="eacb0" RelX="0.0" RelY="0.0" />
      <Point X="1236.0" Y="426.0" GraphRef="f0f23" RelX="1.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e6367">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="304.0" Y="1454.0" GraphRef="afd66" RelX="1.0" RelY="0.0" />
      <Point X="286.52872094050645" Y="1454.9885049192478" GraphRef="be814" RelX="0.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eac6e">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="1112.9999999999995" Y="274.5" GraphRef="af18d" RelX="1.0" RelY="0.0" />
      <Point X="1254.6583333333333" Y="348.0" GraphRef="f8e72" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.1686173212606537" Shape="None" GraphId="f4e37" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eb1bf">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="443.3333333333333" Y="1286.6666666666667" GraphRef="ed284" RelX="0.5" RelY="1.0" />
      <Point X="432.68133634546876" Y="1274.8618038057173" GraphRef="f7ae1" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ebe9b">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="00ff00">
      <Point X="801.0" Y="1410.0" GraphRef="ede5a" RelX="-1.0" RelY="0.0" />
      <Point X="639.0" Y="1410.0" GraphRef="e2b01" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="bdf99" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f72ab">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="834.0" Y="1400.0" GraphRef="ede5a" RelX="-0.5" RelY="-1.0" />
      <Point X="770.5" Y="810.0" />
      <Point X="707.0" Y="1057.0" GraphRef="b4e2e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.6827642656688493" Shape="None" GraphId="b7ea7" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f7b86">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="377.3333333333333" Y="820.1666666666666" GraphRef="fe89e" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
      <Point X="376.0" Y="860.0" GraphRef="ad3c8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f97a6">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="707.0" Y="543.5" GraphRef="a1240" RelX="1.0" RelY="0.0" />
      <Point X="893.0" Y="397.5" />
      <Point X="669.6666666666666" Y="300.8333333333333" GraphRef="e96d3" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.5603120101515264" Shape="None" GraphId="ef04b" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fa2f4">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="513.0" Y="910.0" GraphRef="fb490" RelX="1.0" RelY="0.0" />
      <Point X="840.0" Y="947.0" GraphRef="bbba8" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="c2a80" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fccaf">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="1022.9833333333331" Y="550.5" GraphRef="a5e38" RelX="-1.0" RelY="0.0" />
      <Point X="928.0" Y="412.5" />
      <Point X="1031.9833333333331" Y="274.5" GraphRef="af18d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.44490538573507993" Shape="None" GraphId="a85f4" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fe728">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="368.81485972384314" Y="967.5902814617215" GraphRef="be74a" RelX="0.0" RelY="0.0" />
      <Point X="473.0" Y="920.0" GraphRef="fb490" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ff1ec">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="647.5" Y="1178.0" GraphRef="a2d11" RelX="1.0" RelY="0.0" />
      <Point X="622.3283677077195" Y="1183.375769004125" GraphRef="d52fc" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fff2f">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="950.2" Y="102.0" GraphRef="b3479" RelX="0.0" RelY="0.0" />
      <Point X="982.6666666666665" Y="111.33333333333333" GraphRef="e24cb" RelX="-1.0" RelY="0.0" ArrowHead="LigandSquare" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id6f15de29">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="312.98333333333335" Y="426.25" GraphRef="f22ba" RelX="-1.0" RelY="0.5" />
      <Point X="577.9833333333333" Y="543.5" GraphRef="a1240" RelX="-1.0" RelY="0.0" />
      <Anchor Position="0.4" Shape="None" GraphId="f57af" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id9bb97855">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="935.5" Y="162.0" GraphRef="aef92" RelX="0.0" RelY="1.0" />
      <Point X="924.825" Y="207.33333333333334" GraphRef="b28b8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="c2283" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idbe764277">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="942.0" Y="178.66666666666666" GraphRef="fcf44" RelX="-1.0" RelY="0.0" />
      <Point X="931.23" Y="180.13333333333333" GraphRef="c2283" RelX="0.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idcb178bbf">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="960.0" Y="75.33333333333333" GraphRef="e779b" RelX="0.0" RelY="1.0" />
      <Point X="935.5" Y="142.0" GraphRef="aef92" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="b3479" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cd46b">
    <Graphics ZOrder="32769" LineThickness="1.0">
      <Point X="1041.0" Y="593.0" GraphRef="b71b4" RelX="0.0" RelY="-1.0" />
      <Point X="1044.495" Y="605.6" GraphRef="b0ddf" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f64ea">
    <Graphics ZOrder="32771" LineThickness="1.0">
      <Point X="930.0" Y="771.0" GraphRef="f2f44" RelX="0.0" RelY="-1.0" />
      <Point X="928.2295380673326" Y="778.7197466132055" GraphRef="b1641" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Label TextLabel="Glutathione utilization" GraphId="aa5e5">
    <Graphics CenterX="254.0" CenterY="1692.6666666666667" Width="146.33333333333334" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" Color="ff0000" />
  </Label>
  <Label TextLabel="Taurine and hypotaurine&#xA;metabolism" GraphId="b587d">
    <Graphics CenterX="563.5833333333334" CenterY="1067.0833333333333" Width="120.83333333333333" Height="27.833333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="9" Valign="Middle" Color="0000ff" />
  </Label>
  <Label TextLabel="Serine" GraphId="d7ca8">
    <Graphics CenterX="495.8333333333333" CenterY="369.3333333333333" Width="43.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Glycine" GraphId="de81d">
    <Graphics CenterX="513.1666666666666" CenterY="340.0" Width="61.666666666666664" Height="24.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Cyanoamino&#xA;acid metabolism" GraphId="deafe">
    <Graphics CenterX="786.1666666666666" CenterY="1323.9166666666667" Width="79.66666666666667" Height="24.166666666666668" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="9" Valign="Middle" Color="0000ff" />
  </Label>
  <Label TextLabel="Cysteine metabolism" GraphId="e7d7e">
    <Graphics CenterX="645.9166666666666" CenterY="1001.0" Width="114.16666666666667" Height="15.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="9" Valign="Middle" Color="0000ff" />
  </Label>
  <Label TextLabel="vitamin B2" GraphId="f048c">
    <Graphics CenterX="281.0" CenterY="574.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="vitamin B6" GraphId="f4345">
    <Graphics CenterX="447.3333333333333" CenterY="352.6666666666667" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="g-Glutamyl&#xA;Cycle" GraphId="f6312">
    <Graphics CenterX="654.0" CenterY="1326.6666666666667" Width="79.33333333333333" Height="30.666666666666668" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="0000ff" />
  </Label>
  <Label TextLabel="Glutamate metabolism" GraphId="f82bf">
    <Graphics CenterX="1025.0" CenterY="947.6666666666666" Width="126.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="9" Valign="Middle" Color="0000ff" />
  </Label>
  <Label TextLabel="glutathione recycling" GraphId="f9ab6">
    <Graphics CenterX="344.0" CenterY="1382.6666666666667" Width="139.33333333333334" Height="16.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" Color="008000" />
  </Label>
  <Label TextLabel="Amino acid metabolism" GraphId="fe89e">
    <Graphics CenterX="377.3333333333333" CenterY="812.6666666666666" Width="138.33333333333334" Height="15.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="9" Valign="Middle" Color="0000ff" />
  </Label>
  <Shape GraphId="b3d2e" GroupRef="aa71d">
    <Graphics CenterX="450.6666666666667" CenterY="1631.3333333333333" Width="106.66666666666667" Height="8.666666666666666" ZOrder="16384" FillColor="000000" FontSize="10" Valign="Middle" ShapeType="Brace" Rotation="1.5707963267948966" />
  </Shape>
  <Shape GraphId="c905a" GroupRef="aa71d">
    <Graphics CenterX="230.66666666666666" CenterY="1631.3333333333333" Width="100.0" Height="8.666666666666666" ZOrder="16384" FillColor="000000" FontSize="10" Valign="Middle" ShapeType="Brace" Rotation="4.71238898038469" />
  </Shape>
  <Group GroupId="ddad8" GraphId="ae9a7" />
  <Group GroupId="a04cf" GraphId="b41c4" />
  <Group GroupId="c0264" GraphId="c08a5" />
  <Group GroupId="a4bbd" GraphId="c5445" />
  <Group GroupId="e90bc" GraphId="cacc9" />
  <Group GroupId="aa71d" GraphId="d685d" />
  <Group GroupId="df5aa" GraphId="ed284" />
  <Group GroupId="c455b" GraphId="f0f23" />
  <Group GroupId="f3c18" GraphId="f86e8" />
  <Group GroupId="bdb05" GraphId="fff61" />
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17389618</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and riskof colorectal adenoma in the Nurses' Health Study.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carcinogenesis</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hazra A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wu K</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kraft P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fuchs CS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giovannucci EL</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hunter DJ</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carbon fixation pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000057</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">classic metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000002</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glutathione metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000134</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
  </Biopax>
</Pathway>

