<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Eicosanoid metabolism via lipoxygenases (LOX)" Data-Source="WikiPathways" Version="WP4348_r137934" Author="[Eoinfahy, Ryanmiller, DeSl, Egonw, Eweitz, Conroy lipids, Khanspers]" Last-Modified="20250310183317" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway is inspired by the [Lipidmaps&gt;Eicosanoids Pathway expended pathway display](https://lipidmaps.org/pathway/pathways_maps).
Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX) [WP4347](https://www.wikipathways.org/index.php/Pathway:WP4347), lipooxygenases(LOX) [WP4348](https://www.wikipathways.org/index.php/Pathway:WP4348), or cytochrome P450 monooxygenases (CYP) [WP4349](https://www.wikipathways.org/index.php/Pathway:WP4349).
This pathway visualises the second route, via LOX.
</Comment>
  <BiopaxRef>b6e</BiopaxRef>
  <Graphics BoardWidth="1473.1358624548936" BoardHeight="1048.240740740739" />
  <DataNode TextLabel="Cyp4a10" GraphId="e42a6" Type="GeneProduct" GroupRef="af747">
    <Graphics CenterX="59.3343726379443" CenterY="617.9552154194993" Width="68.95786092214641" Height="23.64814814814851" ZOrder="32933" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="O88833" />
  </DataNode>
  <DataNode TextLabel="Lta4h" GraphId="c7a89" Type="GeneProduct">
    <Graphics CenterX="236.05287296837116" CenterY="484.6224489795917" Width="64.0" Height="22.0" ZOrder="32934" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P24527" />
  </DataNode>
  <DataNode TextLabel="EXA4" GraphId="e8d74" Type="Metabolite">
    <Graphics CenterX="810.4201680672265" CenterY="442.384488525289" Width="90.0" Height="25.0" ZOrder="32935" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020037" />
  </DataNode>
  <DataNode TextLabel="Non-enzymatic" GraphId="d4c1c">
    <Graphics CenterX="545.0" CenterY="430.0" Width="90.0" Height="25.0" ZOrder="32936" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="5-HEDH" GraphId="be773" Type="GeneProduct">
    <Graphics CenterX="1413.1173949797005" CenterY="267.08531339768535" Width="60.03693495038624" Height="25.858324145534652" ZOrder="32937" FontSize="12" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Mgst2" GraphId="d90af" Type="GeneProduct" GroupRef="c2c60">
    <Graphics CenterX="1414.7175925925926" CenterY="154.09259259259258" Width="46.25" Height="25.0" ZOrder="32938" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="A2RST1" />
  </DataNode>
  <DataNode TextLabel="Gpx4" GraphId="c5ab6" Type="GeneProduct" GroupRef="ca6af">
    <Graphics CenterX="421.914280432883" CenterY="224.50729313705725" Width="42.27767695099821" Height="17.94464609800366" ZOrder="32939" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="O70325" />
  </DataNode>
  <DataNode TextLabel="LTA4" GraphId="fec99" Type="Metabolite">
    <Graphics CenterX="663.9445881991164" CenterY="442.384488525289" Width="90.00000000000007" Height="25.00000000000003" ZOrder="32940" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020023" />
  </DataNode>
  <DataNode TextLabel="Cyp4f3" GraphId="c426c" Type="GeneProduct">
    <Graphics CenterX="45.94907407407408" CenterY="813.379629629629" Width="57.73148148148145" Height="25.0" ZOrder="32941" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q99N16" />
  </DataNode>
  <DataNode TextLabel="5,6-Ep-15S-HETE" GraphId="ceab3" Type="Metabolite">
    <Graphics CenterX="982.0534629404622" CenterY="441.34872417983" Width="90.0" Height="25.0" ZOrder="32942" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060075" />
  </DataNode>
  <DataNode TextLabel="20-oxo-leukotriene B4 " GraphId="d7a97" Type="Metabolite">
    <Graphics CenterX="151.20370370370375" CenterY="812.2222222222224" Width="90.0" Height="25.0" ZOrder="32943" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020064" />
  </DataNode>
  <DataNode TextLabel="Arachidonic acid" GraphId="acff2" Type="Metabolite">
    <Graphics CenterX="663.8969691514974" CenterY="107.50753774497642" Width="102.0" Height="25.0" ZOrder="32944" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030001" />
  </DataNode>
  <DataNode TextLabel="Gpx1" GraphId="a010a" Type="GeneProduct" GroupRef="ca6af">
    <Graphics CenterX="421.914280432883" CenterY="205.2014855145527" Width="42.277676950998206" Height="20.66696914700548" ZOrder="32945" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P11352" />
  </DataNode>
  <DataNode TextLabel="Alox5" GraphId="b31d6" Type="GeneProduct">
    <Graphics CenterX="973.829580441805" CenterY="138.57581005876412" Width="90.0" Height="25.0" ZOrder="32946" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P48999" />
  </DataNode>
  <DataNode TextLabel="Mgst3" GraphId="f60b8" Type="GeneProduct" GroupRef="c2c60">
    <Graphics CenterX="1414.7175925925926" CenterY="179.09259259259258" Width="45.0" Height="25.0" ZOrder="32947" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9CPU4" />
  </DataNode>
  <DataNode TextLabel="15S-HpETE" GraphId="c94d9" Type="Metabolite">
    <Graphics CenterX="872.937426415155" CenterY="260.8115330520393" Width="102.0" Height="25.0" ZOrder="32948" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060014" />
  </DataNode>
  <DataNode TextLabel="15S-HETE" GraphId="db32a" Type="Metabolite">
    <Graphics CenterX="1034.664778656117" CenterY="260.8115330520393" Width="102.0" Height="25.0" ZOrder="32949" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060001" />
  </DataNode>
  <DataNode TextLabel="8-HpETE" GraphId="af4a4" Type="Metabolite">
    <Graphics CenterX="1112.3958710930892" CenterY="175.09545337122185" Width="102.0" Height="25.0" ZOrder="32950" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060073" />
  </DataNode>
  <DataNode TextLabel="8S-HETE" GraphId="b6dd3" Type="Metabolite">
    <Graphics CenterX="1276.6612123846971" CenterY="175.09545337122182" Width="102.0" Height="25.0" ZOrder="32951" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060006" />
  </DataNode>
  <DataNode TextLabel="15-oxoETE" GraphId="c6faa" Type="Metabolite">
    <Graphics CenterX="1198.9301199477197" CenterY="260.8115330520393" Width="102.0" Height="25.0" ZOrder="32952" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060051" />
  </DataNode>
  <DataNode TextLabel="Alox15" GraphId="b9f0c" Type="GeneProduct">
    <Graphics CenterX="923.0754327911836" CenterY="207.40829243089635" Width="60.49170469875753" Height="25.0" ZOrder="32953" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11687" />
  </DataNode>
  <DataNode TextLabel="LXA4" GraphId="d90c5" Type="Metabolite">
    <Graphics CenterX="981.7740583825364" CenterY="563.8911713928472" Width="102.0" Height="25.0" ZOrder="32954" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03040001" />
  </DataNode>
  <DataNode TextLabel="Hpgd" GraphId="a6f6f" Type="GeneProduct">
    <Graphics CenterX="1068.5350818656839" CenterY="653.3190158160754" Width="58.113304552651925" Height="25.0" ZOrder="32955" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8VCC1" />
  </DataNode>
  <DataNode TextLabel="12S-HpETE" GraphId="eb655" Type="Metabolite">
    <Graphics CenterX="474.0827772649873" CenterY="107.50753774497645" Width="102.0" Height="25.0" ZOrder="32956" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060013" />
  </DataNode>
  <DataNode TextLabel="12S-HETE" GraphId="b0bc7" Type="Metabolite">
    <Graphics CenterX="277.90212884531115" CenterY="276.0181094524695" Width="102.0" Height="25.0" ZOrder="32957" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060007" />
  </DataNode>
  <DataNode TextLabel="12-oxoETE" GraphId="b9063" Type="Metabolite">
    <Graphics CenterX="111.90212884531135" CenterY="276.0181094524695" Width="102.0" Height="25.0" ZOrder="32958" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060019" />
  </DataNode>
  <DataNode TextLabel="HXB3" GraphId="a3a22" Type="Metabolite">
    <Graphics CenterX="277.90212884531115" CenterY="199.0" Width="102.0" Height="25.0" ZOrder="32959" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03090003" />
  </DataNode>
  <DataNode TextLabel="HXA3" GraphId="b4fe0" Type="Metabolite">
    <Graphics CenterX="288.8249513370422" CenterY="107.50753774497642" Width="102.0" Height="25.0" ZOrder="32960" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03090005" />
  </DataNode>
  <DataNode TextLabel="Trioxilin A3" GraphId="c11b7" Type="Metabolite">
    <Graphics CenterX="112.82495133704234" CenterY="106.50753774497642" Width="102.0" Height="25.0" ZOrder="32961" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03090002" />
  </DataNode>
  <DataNode TextLabel="Trioxilin B3" GraphId="ac3c8" Type="Metabolite">
    <Graphics CenterX="111.90212884531135" CenterY="200.0" Width="102.0" Height="25.0" ZOrder="32962" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03090004" />
  </DataNode>
  <DataNode TextLabel="Ephx2" GraphId="ecc29" Type="GeneProduct">
    <Graphics CenterX="202.67706685278927" CenterY="147.78493317132444" Width="65.0" Height="25.0" ZOrder="32963" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P34914" />
  </DataNode>
  <DataNode TextLabel="12-HEDH" GraphId="d5120" Type="GeneProduct">
    <Graphics CenterX="200.67706685278927" CenterY="232.26010334096435" Width="90.0" Height="25.0" ZOrder="32964" FontSize="12" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="LXB4" GraphId="fc694" Type="Metabolite">
    <Graphics CenterX="429.83118908837133" CenterY="313.6775156371199" Width="79.95369349503972" Height="23.153252480705646" ZOrder="32965" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03040002" />
  </DataNode>
  <DataNode TextLabel="LTB4" GraphId="c6998" Type="Metabolite">
    <Graphics CenterX="151.20370370370372" CenterY="586.2809553810497" Width="90.0" Height="25.0" ZOrder="32966" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020001" />
  </DataNode>
  <DataNode TextLabel="12-epi-LTB4" GraphId="c2239" Type="Metabolite">
    <Graphics CenterX="423.8788081359904" CenterY="510.52961105804616" Width="90.0" Height="25.0" ZOrder="32967" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020015" />
  </DataNode>
  <DataNode TextLabel="6-trans-12-epi-delta-LTB4" GraphId="f3644" Type="Metabolite">
    <Graphics CenterX="425.87880813599037" CenterY="390.540546659504" Width="157.0" Height="25.0" ZOrder="32968" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020014" />
  </DataNode>
  <DataNode TextLabel="6-trans-delta-LTB4" GraphId="db0e0" Type="Metabolite">
    <Graphics CenterX="427.8788081359904" CenterY="475.8300071939462" Width="121.0" Height="25.0" ZOrder="32969" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020013" />
  </DataNode>
  <DataNode TextLabel="LTC4" GraphId="c303c" Type="Metabolite">
    <Graphics CenterX="663.8969691514974" CenterY="622.3640243307902" Width="90.0" Height="25.0" ZOrder="32970" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020003" />
  </DataNode>
  <DataNode TextLabel="LTD4" GraphId="c0d7f" Type="Metabolite">
    <Graphics CenterX="663.8969691514974" CenterY="729.4805818689102" Width="90.0" Height="25.0" ZOrder="32971" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020006" />
  </DataNode>
  <DataNode TextLabel="LTE4" GraphId="d1a07" Type="Metabolite">
    <Graphics CenterX="663.8969691514974" CenterY="846.5380374862183" Width="90.0" Height="25.0" ZOrder="32972" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020002" />
  </DataNode>
  <DataNode TextLabel="EXC4" GraphId="e4e65" Type="Metabolite">
    <Graphics CenterX="814.1797133406836" CenterY="622.3640243307902" Width="90.0" Height="25.0" ZOrder="32973" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020031" />
  </DataNode>
  <DataNode TextLabel="EXD4" GraphId="ebe00" Type="Metabolite">
    <Graphics CenterX="815.1320942930645" CenterY="729.4805818689102" Width="90.0" Height="25.0" ZOrder="32974" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020032" />
  </DataNode>
  <DataNode TextLabel="EXE4" GraphId="bfe05" Type="Metabolite">
    <Graphics CenterX="815.0440175757743" CenterY="846.7241534191949" Width="90.0" Height="25.0" ZOrder="32975" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020033" />
  </DataNode>
  <DataNode TextLabel="20-hydroxy-LTB4" GraphId="fe98b" Type="Metabolite">
    <Graphics CenterX="151.20370370370375" CenterY="729.4805818689102" Width="98.09151047409034" Height="25.0" ZOrder="32976" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020018" />
  </DataNode>
  <DataNode TextLabel="20-carboxy-LTB4" GraphId="d6555" Type="Metabolite">
    <Graphics CenterX="151.20370370370378" CenterY="902.0343752838616" Width="107.60418963616304" Height="25.0" ZOrder="32977" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020016" />
  </DataNode>
  <DataNode TextLabel="18-carboxy-&#xA;dinor-LTB4" GraphId="b437e" Type="Metabolite">
    <Graphics CenterX="151.20370370370375" CenterY="1003.900237174373" Width="75.961444996962" Height="28.681007132731935" ZOrder="32978" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01170145" />
  </DataNode>
  <DataNode TextLabel="11-trans-LTC4" GraphId="f678d" Type="Metabolite">
    <Graphics CenterX="428.8788081359904" CenterY="622.3640243307902" Width="133.57883131201655" Height="25.0" ZOrder="32979" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020020" />
  </DataNode>
  <DataNode TextLabel="11-trans-LTD4" GraphId="dd528" Type="Metabolite">
    <Graphics CenterX="428.8788081359904" CenterY="729.4805818689102" Width="127.16868798235862" Height="25.0" ZOrder="32980" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020021" />
  </DataNode>
  <DataNode TextLabel="11-trans-LTE4" GraphId="b77d1" Type="Metabolite">
    <Graphics CenterX="428.87880813599037" CenterY="846.5380374862183" Width="125.16868798235862" Height="20.5573318632853" ZOrder="32981" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020022" />
  </DataNode>
  <DataNode TextLabel="5S-HpETE" GraphId="f438d" Type="Metabolite">
    <Graphics CenterX="1346.748897837404" CenterY="107.50753774497642" Width="102.0" Height="25.0" ZOrder="32982" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060012" />
  </DataNode>
  <DataNode TextLabel="5S-HETE" GraphId="a7265" Type="Metabolite">
    <Graphics CenterX="1346.7488978374038" CenterY="219.3640693322544" Width="102.0" Height="25.0" ZOrder="32983" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060084" />
  </DataNode>
  <DataNode TextLabel="5-oxoETE" GraphId="a2b9b" Type="Metabolite">
    <Graphics CenterX="1346.748897837404" CenterY="332.65367999460074" Width="102.0" Height="25.0" ZOrder="32984" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060011" />
  </DataNode>
  <DataNode TextLabel="15-oxo-LXA4" GraphId="ced6f" Type="Metabolite">
    <Graphics CenterX="981.7740583825364" CenterY="743.8707071983463" Width="102.0" Height="25.0" ZOrder="32985" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03040009" />
  </DataNode>
  <DataNode TextLabel="13,14-dihydro-&#xA;15-oxo-LXA4" GraphId="e89e6" Type="Metabolite">
    <Graphics CenterX="981.7740583825365" CenterY="850.9872647364664" Width="112.35023967392964" Height="31.62463685133116" ZOrder="32986" FontSize="12" Valign="Middle" Color="3300ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03040008" />
  </DataNode>
  <DataNode TextLabel="12-oxo-LTB4" GraphId="a3c7d" Type="Metabolite">
    <Graphics CenterX="329.2278311545125" CenterY="586.2809553810497" Width="90.0" Height="25.0" ZOrder="32987" FontSize="12" Valign="Middle" Color="3300ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03020024" />
  </DataNode>
  <DataNode TextLabel="Ltc4s" GraphId="f38bc" Type="GeneProduct">
    <Graphics CenterX="745.0545664727774" CenterY="548.7775633958103" Width="60.03693495038624" Height="25.858324145534652" ZOrder="32988" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q60860" />
  </DataNode>
  <DataNode TextLabel="Cyp4a12a" GraphId="d14bf" Type="GeneProduct" GroupRef="af747">
    <Graphics CenterX="58.3343726379443" CenterY="641.6033635676478" Width="68.95786092214641" Height="23.648148148148493" ZOrder="32989" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q91WL5" />
  </DataNode>
  <DataNode TextLabel="Cyp4a12b" GraphId="a2a52" Type="GeneProduct" GroupRef="af747">
    <Graphics CenterX="58.3343726379443" CenterY="665.2515117157964" Width="68.95786092214641" Height="23.64814814814851" ZOrder="32990" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="A2A974" />
  </DataNode>
  <DataNode TextLabel="Cyp4f14" GraphId="ec3f8" Type="GeneProduct" GroupRef="af747">
    <Graphics CenterX="58.3343726379443" CenterY="688.8996598639449" Width="68.95786092214641" Height="23.64814814814851" ZOrder="32991" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9EP75" />
  </DataNode>
  <DataNode TextLabel="Cyp4f18" GraphId="ba32d" Type="GeneProduct" GroupRef="af747">
    <Graphics CenterX="58.3343726379443" CenterY="712.5478080120934" Width="68.95786092214641" Height="23.64814814814851" ZOrder="32992" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q99N16" />
  </DataNode>
  <DataNode TextLabel="Acox1" GraphId="ab247" Type="GeneProduct" GroupRef="d4fc5">
    <Graphics CenterX="58.3343726379443" CenterY="910.400037792892" Width="58.794595616024175" Height="23.64814814814851" ZOrder="32993" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9R0H0" />
  </DataNode>
  <DataNode TextLabel="Acox2" GraphId="ba4ca" Type="GeneProduct" GroupRef="d4fc5">
    <Graphics CenterX="58.3343726379443" CenterY="934.0481859410405" Width="58.794595616024175" Height="23.64814814814851" ZOrder="32994" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9QXD1" />
  </DataNode>
  <DataNode TextLabel="Acox3" GraphId="b06c7" Type="GeneProduct" GroupRef="d4fc5">
    <Graphics CenterX="58.334372637944284" CenterY="957.6963340891889" Width="58.79459561602418" Height="23.648148148148493" ZOrder="32995" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q3TAW3" />
  </DataNode>
  <DataNode TextLabel="Ehhadh" GraphId="fa879" Type="GeneProduct" GroupRef="d4fc5">
    <Graphics CenterX="58.3343726379443" CenterY="981.3444822373374" Width="58.794595616024175" Height="23.64814814814851" ZOrder="32996" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9DBM2" />
  </DataNode>
  <DataNode TextLabel="Acaa1a" GraphId="de7f4" Type="GeneProduct" GroupRef="d4fc5">
    <Graphics CenterX="58.3343726379443" CenterY="1004.9926303854858" Width="58.794595616024175" Height="23.64814814814851" ZOrder="32997" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q921H8" />
  </DataNode>
  <DataNode TextLabel="Ggt1" GraphId="e88de" Type="GeneProduct">
    <Graphics CenterX="745.1462214188628" CenterY="661.8240740740737" Width="61.71738331495769" Height="21.33333333333332" ZOrder="32998" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q60928" />
  </DataNode>
  <DataNode TextLabel="Ggt5" GraphId="c2ad3" Type="GeneProduct">
    <Graphics CenterX="745.1462214188628" CenterY="678.3650312385151" Width="61.71738331495769" Height="19.26993752296906" ZOrder="32999" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9Z2A9" />
  </DataNode>
  <DataNode TextLabel="Dpep1" GraphId="ba5ad" Type="GeneProduct" GroupRef="c3f07">
    <Graphics CenterX="745.30362882627" CenterY="772.1759259259255" Width="61.71738331495769" Height="21.33333333333332" ZOrder="33000" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P31428" />
  </DataNode>
  <DataNode TextLabel="Dpep2" GraphId="bf562" Type="GeneProduct" GroupRef="c3f07">
    <Graphics CenterX="745.30362882627" CenterY="789.2076238311078" Width="61.71738331495769" Height="19.26993752296906" ZOrder="33001" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8C255" />
  </DataNode>
  <DataNode TextLabel="Alox12" GraphId="cea55" Type="GeneProduct">
    <Graphics CenterX="575.6923925027563" CenterY="242.69239250275632" Width="90.0" Height="25.0" ZOrder="33004" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11684" />
  </DataNode>
  <DataNode TextLabel="Alox5" GraphId="a11a0" Type="GeneProduct">
    <Graphics CenterX="739.2300647286097" CenterY="249.29528937100093" Width="56.407859505434715" Height="25.0" ZOrder="33005" FontWeight="Bold" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P48999" />
  </DataNode>
  <DataNode TextLabel="Ptgr1" GraphId="d83f5" Type="GeneProduct" GroupRef="e12ed">
    <Comment>AKA Ltb4dh</Comment>
    <Graphics CenterX="1041.5591208235994" CenterY="781.5598727792441" Width="61.71738331495769" Height="21.33333333333332" ZOrder="33006" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q91YR9" />
  </DataNode>
  <DataNode TextLabel="Ptgr2" GraphId="d256e" Type="GeneProduct" GroupRef="e12ed">
    <Comment>AKA Zadh1</Comment>
    <Graphics CenterX="1041.5591208235994" CenterY="799.258237351093" Width="61.71738331495769" Height="19.26993752296906" ZOrder="33007" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8VDQ1" />
  </DataNode>
  <DataNode TextLabel="Hpgd" GraphId="ecb6e" Type="GeneProduct">
    <Graphics CenterX="1121.4410386223212" CenterY="301.48296164562123" Width="60.813942383206275" Height="25.0" ZOrder="33008" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8VCC1" />
  </DataNode>
  <DataNode TextLabel="Alox5" GraphId="f23c5" Type="GeneProduct">
    <Graphics CenterX="998.5242479623196" CenterY="368.1554970881839" Width="55.06439826440305" Height="25.0" ZOrder="33009" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P48999" />
  </DataNode>
  <DataNode TextLabel="5S-HpETE" GraphId="aa2bc" Type="Metabolite">
    <Graphics CenterX="662.5598572185675" CenterY="207.19963948527106" Width="68.37426146647954" Height="25.0" ZOrder="33010" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA03060012" />
  </DataNode>
  <DataNode TextLabel="Alox15" GraphId="e3a58" Type="GeneProduct">
    <Graphics CenterX="391.730339075636" CenterY="68.56595505493114" Width="60.49170469875753" Height="25.0" ZOrder="33011" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11687" />
  </DataNode>
  <DataNode TextLabel="Alox15" GraphId="c21e9" Type="GeneProduct">
    <Graphics CenterX="779.7278694610375" CenterY="343.4587125989633" Width="49.95994060274744" Height="25.0" ZOrder="33013" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11687" />
  </DataNode>
  <DataNode TextLabel="Ptgr1" GraphId="c0e63" Type="GeneProduct" GroupRef="dbf2c">
    <Comment>AKA Ltb4dh</Comment>
    <Graphics CenterX="233.55912082359941" CenterY="634.5598727792441" Width="61.71738331495769" Height="21.33333333333332" ZOrder="33015" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q91YR9" />
  </DataNode>
  <DataNode TextLabel="Ptgr2" GraphId="fa006" Type="GeneProduct" GroupRef="dbf2c">
    <Comment>AKA Zadh1</Comment>
    <Graphics CenterX="233.55912082359941" CenterY="652.258237351093" Width="61.71738331495769" Height="19.26993752296906" ZOrder="33016" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8VDQ1" />
  </DataNode>
  <Interaction GraphId="cbefa">
    <Graphics ZOrder="32845" LineThickness="1.0">
      <Point X="1002.7004291661206" Y="789.8932061125774" GraphRef="c630e" RelX="-1.0" RelY="0.0" />
      <Point X="981.7740583825365" Y="790.972224358414" GraphRef="ff04e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ff91c">
    <Graphics ZOrder="32858" LineThickness="1.0">
      <Point X="567.5" Y="442.5" GraphRef="d4c1c" RelX="0.5" RelY="1.0" />
      <Point X="570.0" Y="510.52961105804616" GraphRef="c927b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ba206">
    <Graphics ZOrder="32859" LineThickness="2.0">
      <Point X="982.0534629404622" Y="453.84872417983" GraphRef="ceab3" RelX="0.0" RelY="1.0" />
      <Point X="981.7740583825364" Y="551.3911713928472" GraphRef="d90c5" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dab8e">
    <Comment>EC:3.4.19.14</Comment>
    <Graphics ZOrder="32860" LineThickness="1.0">
      <Point X="663.8969691514974" Y="634.8640243307902" GraphRef="c303c" RelX="0.0" RelY="1.0" />
      <Point X="663.8969691514974" Y="716.9805818689102" GraphRef="c0d7f" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4213707709800799" Shape="None" GraphId="b3d6d" />
    </Graphics>
    <Xref Database="Rhea" ID="31564" />
  </Interaction>
  <Interaction GraphId="a5f72">
    <Graphics ZOrder="32861" LineThickness="1.0">
      <Point X="233.55912082359941" Y="615.8932061125774" GraphRef="f10af" RelX="0.0" RelY="-1.0" />
      <Point X="231.41335468402724" Y="586.2809553810497" GraphRef="c73c6" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="db5f7">
    <Graphics ZOrder="32862" LineThickness="1.0">
      <Point X="1121.4410386223212" Y="288.98296164562123" GraphRef="ecb6e" RelX="0.0" RelY="-1.0" />
      <Point X="1120.4188485381515" Y="260.8115330520393" GraphRef="f0d6e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c593e">
    <Graphics ZOrder="32863" LineThickness="1.0">
      <Point X="686.4445881991164" Y="454.88448852528904" GraphRef="fec99" RelX="0.5" RelY="1.0" />
      <Point X="686.3969691514974" Y="609.8640243307902" GraphRef="c303c" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6182335959157689" Shape="None" GraphId="e731b" />
    </Graphics>
    <Xref Database="Rhea" ID="17619" />
  </Interaction>
  <Interaction GraphId="e9261">
    <Graphics ZOrder="32864" LineThickness="1.0">
      <Point X="575.6923925027563" Y="255.19239250275632" GraphRef="cea55" RelX="0.0" RelY="1.0" />
      <Point X="618.802792604074" Y="313.6775156371199" GraphRef="ddbf5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e4fcb">
    <Graphics ZOrder="32865" LineThickness="1.0">
      <Point X="784.0049130763416" Y="669.5787037037034" />
      <Point X="814.5810188368552" Y="669.465541490858" GraphRef="ef73d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="de5fd">
    <Graphics ZOrder="32866" LineThickness="1.0">
      <Point X="1383.0989275045074" Y="267.08531339768535" GraphRef="be773" RelX="-1.0" RelY="0.0" />
      <Point X="1346.7488978374038" Y="267.1799135971929" GraphRef="ebe97" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e4ff8">
    <Graphics ZOrder="32867" LineThickness="1.0">
      <Point X="715.0360989975843" Y="548.7775633958103" GraphRef="f38bc" RelX="-1.0" RelY="0.0" />
      <Point X="686.4151485040728" Y="550.6980442396807" GraphRef="e731b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d4601">
    <Graphics ZOrder="32868" LineThickness="1.0">
      <Point X="237.8249513370422" Y="107.50753774497642" GraphRef="b4fe0" RelX="-1.0" RelY="0.0" />
      <Point X="163.82495133704234" Y="106.50753774497642" GraphRef="c11b7" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="b2b9d" />
    </Graphics>
    <Xref Database="Rhea" ID="50897" />
  </Interaction>
  <Interaction GraphId="b6552">
    <Graphics ZOrder="32869" LineThickness="2.0">
      <Point X="815.1320942930645" Y="741.9805818689102" GraphRef="ebe00" RelX="0.0" RelY="1.0" />
      <Point X="815.0440175757743" Y="834.2241534191949" GraphRef="bfe05" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4192606723078079" Shape="None" GraphId="b2287" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d0c09">
    <Graphics ZOrder="32870" LineThickness="1.0">
      <Point X="970.9920488301182" Y="368.1554970881839" GraphRef="f23c5" RelX="-1.0" RelY="0.0" />
      <Point X="949.0715748909635" Y="381.83537592537334" GraphRef="b2d23" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c388d">
    <Comment>EC:3.3.2.6</Comment>
    <Graphics ConnectorType="Elbow" ZOrder="32871" LineThickness="1.0">
      <Point X="663.9445881991164" Y="454.88448852528904" GraphRef="fec99" RelX="0.0" RelY="1.0" />
      <Point X="407.57414595141006" Y="533.8775510204082" />
      <Point X="151.20370370370372" Y="573.7809553810497" GraphRef="c6998" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.812453553364854" Shape="None" GraphId="af075" />
    </Graphics>
    <Xref Database="Rhea" ID="22325" />
  </Interaction>
  <Interaction GraphId="a1011">
    <Graphics ZOrder="32872" LineThickness="1.0">
      <Point X="706.4449371687912" Y="780.1759259259256" GraphRef="bb488" RelX="-1.0" RelY="0.0" />
      <Point X="663.8969691514974" Y="781.9831223628693" GraphRef="a811b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ecbd0">
    <Graphics ZOrder="32873" LineStyle="Broken" LineThickness="1.0">
      <Point X="151.2037037037038" Y="914.5343752838616" GraphRef="d6555" RelX="0.0" RelY="1.0" />
      <Point X="151.20370370370375" Y="989.559733608007" GraphRef="b437e" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.583234613502116" Shape="None" GraphId="dba7f" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b5e1f">
    <Graphics ZOrder="32874" LineThickness="2.0">
      <Point X="226.90212884531115" Y="276.0181094524695" GraphRef="b0bc7" RelX="-1.0" RelY="0.0" />
      <Point X="162.90212884531135" Y="276.0181094524695" GraphRef="b9063" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.38750906413736896" Shape="None" GraphId="c91d8" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c98db">
    <Comment>EC:1.13.11.33</Comment>
    <Graphics ZOrder="32875" LineThickness="1.0">
      <Point X="714.8969691514974" Y="113.75753774497642" GraphRef="acff2" RelX="1.0" RelY="0.5" />
      <Point X="821.937426415155" Y="260.8115330520393" GraphRef="c94d9" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6364450351108315" Shape="None" GraphId="f14d0" />
    </Graphics>
    <Xref Database="Rhea" ID="16870" />
  </Interaction>
  <Interaction GraphId="da33b">
    <Graphics ZOrder="32876" LineThickness="2.0">
      <Point X="618.8969691514974" Y="846.5380374862183" GraphRef="d1a07" RelX="-1.0" RelY="0.0" />
      <Point X="491.4631521271697" Y="846.5380374862183" GraphRef="b77d1" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b811d">
    <Graphics ZOrder="32877" LineThickness="1.0">
      <Point X="391.730339075636" Y="81.06595505493114" GraphRef="e3a58" RelX="0.0" RelY="1.0" />
      <Point X="389.77964689380923" Y="107.50753774497643" GraphRef="c85f5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d4468">
    <Graphics ZOrder="32878" LineThickness="2.0">
      <Point X="810.4201680672265" Y="454.884488525289" GraphRef="e8d74" RelX="0.0" RelY="1.0" />
      <Point X="814.1797133406836" Y="609.8640243307902" GraphRef="e4e65" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6163166738124957" Shape="None" GraphId="ebab8" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c6193">
    <Graphics ZOrder="32879" LineThickness="1.0">
      <Point X="226.90212884531115" Y="199.0" GraphRef="a3a22" RelX="-1.0" RelY="0.0" />
      <Point X="162.90212884531135" Y="200.0" GraphRef="ac3c8" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="e82fd" />
    </Graphics>
    <Xref Database="Rhea" ID="50901" />
  </Interaction>
  <Interaction GraphId="d455e">
    <Graphics ZOrder="32880" LineThickness="1.0">
      <Point X="981.7740583825364" Y="756.3707071983463" GraphRef="ced6f" RelX="0.0" RelY="1.0" />
      <Point X="981.7740583825366" Y="835.1749463108008" GraphRef="e89e6" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4390819269340443" Shape="None" GraphId="ff04e" />
    </Graphics>
    <Xref Database="Rhea" ID="41593" />
  </Interaction>
  <Interaction GraphId="c7905">
    <Graphics ZOrder="32881" LineThickness="2.0">
      <Point X="423.08277726498727" Y="107.50753774497645" GraphRef="eb655" RelX="-1.0" RelY="0.0" />
      <Point X="328.90212884531115" Y="199.0" GraphRef="a3a22" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f1893">
    <Comment>EC:1.13.11.34</Comment>
    <Graphics ZOrder="32882" LineStyle="Broken" LineThickness="1.0">
      <Point X="663.8969691514974" Y="120.00753774497642" GraphRef="acff2" RelX="0.0" RelY="1.0" />
      <Point X="663.9445881991164" Y="429.88448852528904" GraphRef="fec99" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.7841178393336683" Shape="None" GraphId="b3454" />
    </Graphics>
    <Xref Database="Rhea" ID="32308" />
  </Interaction>
  <Interaction GraphId="dea5e">
    <Graphics ConnectorType="Elbow" ZOrder="32883" LineThickness="1.0">
      <Point X="618.9445881991164" Y="436.13448852528904" GraphRef="fec99" RelX="-1.0" RelY="-0.5" />
      <Point X="504.37880813599037" Y="390.540546659504" GraphRef="f3644" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.6324111793657425" Shape="None" GraphId="c4e62" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e186d">
    <Graphics ZOrder="32884" LineThickness="1.0">
      <Point X="1383.5925925925926" Y="166.59259259259258" GraphRef="cb984" RelX="-1.0" RelY="0.0" />
      <Point X="1346.7488978374038" Y="167.0" GraphRef="ae4ba" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bf9d5">
    <Comment>EC:1.14.14.94</Comment>
    <Graphics ZOrder="32885" LineThickness="1.0">
      <Point X="151.20370370370372" Y="598.7809553810497" GraphRef="c6998" RelX="0.0" RelY="1.0" />
      <Point X="151.20370370370375" Y="716.9805818689102" GraphRef="fe98b" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.5731799573055872" Shape="None" GraphId="b4ffc" />
    </Graphics>
    <Xref Database="Rhea" ID="22177" />
  </Interaction>
  <Interaction GraphId="cf264">
    <Graphics ZOrder="32886" LineThickness="1.0">
      <Point X="706.2875297613839" Y="669.5787037037034" />
      <Point X="663.8969691514974" Y="669.465541490858" GraphRef="b3d6d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c8516">
    <Graphics ZOrder="32887" LineThickness="1.0">
      <Point X="202.67706685278927" Y="135.28493317132444" GraphRef="ecc29" RelX="0.0" RelY="-1.0" />
      <Point X="208.22495133704226" Y="107.10753774497641" GraphRef="b2b9d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c8077">
    <Graphics ZOrder="32888" LineThickness="1.0">
      <Point X="663.8969691514974" Y="741.9805818689102" GraphRef="c0d7f" RelX="0.0" RelY="1.0" />
      <Point X="663.8969691514974" Y="834.0380374862183" GraphRef="d1a07" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.43453884561239176" Shape="None" GraphId="a811b" />
    </Graphics>
    <Xref Database="Rhea" ID="48617" />
  </Interaction>
  <Interaction GraphId="a2c4c">
    <Graphics ZOrder="32889" LineThickness="1.0">
      <Point X="236.05287296837116" Y="473.6224489795917" GraphRef="c7a89" RelX="0.0" RelY="-1.0" />
      <Point X="229.76164015100994" Y="533.8775510204082" GraphRef="af075" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b6263">
    <Graphics ConnectorType="Elbow" ZOrder="32890" LineThickness="1.0">
      <Point X="618.9445881991164" Y="442.38448852528904" GraphRef="fec99" RelX="-1.0" RelY="0.0" />
      <Point X="488.3788081359904" Y="475.8300071939462" GraphRef="db0e0" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.5841804884867037" Shape="None" GraphId="b7959" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a85d7">
    <Comment>EC:1.13.11.33</Comment>
    <Graphics ZOrder="32891" LineThickness="1.0">
      <Point X="872.937426415155" Y="273.3115330520393" GraphRef="c94d9" RelX="0.0" RelY="1.0" />
      <Point X="810.4201680672265" Y="429.884488525289" GraphRef="e8d74" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="d398f" />
    </Graphics>
    <Xref Database="Rhea" ID="50141" />
  </Interaction>
  <Interaction GraphId="fcf7c">
    <Graphics ZOrder="32892" LineThickness="1.0">
      <Point X="575.6923925027563" Y="230.19239250275632" GraphRef="cea55" RelX="0.0" RelY="-1.0" />
      <Point X="588.3265119444809" Y="107.50753774497643" GraphRef="d877b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d9e00">
    <Graphics ConnectorType="Elbow" ZOrder="32893" LineThickness="1.0">
      <Point X="641.4445881991164" Y="454.88448852528904" GraphRef="fec99" RelX="-0.5" RelY="1.0" />
      <Point X="468.8788081359904" Y="510.52961105804616" GraphRef="c2239" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.5568958769552065" Shape="None" GraphId="c927b" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ccb7b">
    <Graphics ZOrder="32894" LineThickness="2.0">
      <Point X="618.8969691514974" Y="622.3640243307902" GraphRef="c303c" RelX="-1.0" RelY="0.0" />
      <Point X="495.6682237919987" Y="622.3640243307902" GraphRef="f678d" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ff356">
    <Comment>EC:1.1.1.232</Comment>
    <Graphics ZOrder="32895" LineThickness="1.0">
      <Point X="1085.664778656117" Y="260.8115330520393" GraphRef="db32a" RelX="1.0" RelY="0.0" />
      <Point X="1147.9301199477197" Y="260.8115330520393" GraphRef="c6faa" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.5581607546206687" Shape="None" GraphId="f0d6e" />
    </Graphics>
    <Xref Database="Rhea" ID="23261" />
  </Interaction>
  <Interaction GraphId="dcbc5">
    <Graphics ZOrder="32896" LineThickness="1.0">
      <Point X="973.829580441805" Y="126.07581005876412" GraphRef="b31d6" RelX="0.0" RelY="-1.0" />
      <Point X="920.5808700233739" Y="101.25753774497642" GraphRef="d8279" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fe242">
    <Graphics ZOrder="32897" LineThickness="1.0">
      <Point X="679.6534225851874" Y="219.69963948527106" GraphRef="aa2bc" RelX="0.5" RelY="1.0" />
      <Point X="686.4445881991164" Y="429.88448852528904" GraphRef="fec99" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6710049038138296" Shape="None" GraphId="e988e" />
    </Graphics>
    <Xref Database="Rhea" ID="17962" />
  </Interaction>
  <Interaction GraphId="e048c">
    <Graphics ZOrder="32898" LineThickness="1.0">
      <Point X="775.0730339479705" Y="548.7775633958103" GraphRef="f38bc" RelX="1.0" RelY="0.0" />
      <Point X="812.737238505211" Y="550.4009605419401" GraphRef="ebab8" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e03f5">
    <Graphics ZOrder="32899" LineThickness="2.0">
      <Point X="1346.7488978374038" Y="231.8640693322544" GraphRef="a7265" RelX="0.0" RelY="1.0" />
      <Point X="1346.748897837404" Y="320.15367999460074" GraphRef="a2b9b" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="ebe97" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ac115">
    <Graphics ZOrder="32900" LineThickness="1.0">
      <Point X="74.81481481481481" Y="807.129629629629" GraphRef="c426c" RelX="1.0" RelY="-0.5" />
      <Point X="151.20370370370375" Y="765.0772380102351" GraphRef="d844b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ecb5c">
    <BiopaxRef>b63</BiopaxRef>
    <Graphics ZOrder="32901" LineThickness="1.0">
      <Point X="545.0" Y="417.5" GraphRef="d4c1c" RelX="0.0" RelY="-1.0" />
      <Point X="563.2517314329494" Y="390.540546659504" GraphRef="c4e62" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ae896">
    <Graphics ZOrder="32902" LineThickness="1.0">
      <Point X="923.937426415155" Y="260.8115330520393" GraphRef="c94d9" RelX="1.0" RelY="0.0" />
      <Point X="983.664778656117" Y="260.8115330520393" GraphRef="db32a" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="Rhea" ID="48857" />
  </Interaction>
  <Interaction GraphId="ac188">
    <Graphics ZOrder="32903" LineThickness="1.0">
      <Point X="1346.748897837404" Y="120.00753774497642" GraphRef="f438d" RelX="0.0" RelY="1.0" />
      <Point X="1346.7488978374038" Y="206.8640693322544" GraphRef="a7265" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.5410354454207408" Shape="None" GraphId="ae4ba" />
    </Graphics>
    <Xref Database="Rhea" ID="48621" />
  </Interaction>
  <Interaction GraphId="ec042">
    <Graphics ZOrder="32904" LineThickness="1.0">
      <Point X="612.8969691514974" Y="107.50753774497642" GraphRef="acff2" RelX="-1.0" RelY="0.0" />
      <Point X="525.0827772649873" Y="107.50753774497645" GraphRef="eb655" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.27980052744516587" Shape="None" GraphId="d877b" />
    </Graphics>
    <Xref Database="Rhea" ID="10429" />
  </Interaction>
  <Interaction GraphId="dd129">
    <Graphics ZOrder="32905" LineThickness="1.0">
      <Point X="714.8969691514974" Y="101.25753774497642" GraphRef="acff2" RelX="1.0" RelY="-0.5" />
      <Point X="1295.748897837404" Y="101.25753774497642" GraphRef="f438d" RelX="-1.0" RelY="-0.5" ArrowHead="mim-conversion" />
      <Anchor Position="0.35410728744106357" Shape="None" GraphId="d8279" />
    </Graphics>
    <Xref Database="Rhea" ID="17486" />
  </Interaction>
  <Interaction GraphId="e4d53">
    <Graphics ZOrder="32906" LineThickness="1.0">
      <Point X="725.128099852251" Y="236.79528937100093" GraphRef="a11a0" RelX="-0.5" RelY="-1.0" />
      <Point X="685.4995505249734" Y="149.88437844109427" GraphRef="bbf29" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f106c">
    <Graphics ZOrder="32907" LineThickness="1.0">
      <Point X="74.81481481481481" Y="813.379629629629" GraphRef="c426c" RelX="1.0" RelY="0.0" />
      <Point X="151.20370370370378" Y="850.647083446878" GraphRef="dbf26" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ac059">
    <Graphics ZOrder="32908" LineThickness="1.0">
      <Point X="784.1623204837489" Y="780.1759259259256" GraphRef="bb488" RelX="1.0" RelY="0.0" />
      <Point X="815.0951671893588" Y="780.6546836931559" GraphRef="b2287" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e86e1">
    <Comment>EC:1.11.1.9</Comment>
    <Graphics ZOrder="32909" LineThickness="1.0">
      <Point X="423.08277726498727" Y="107.50753774497645" GraphRef="eb655" RelX="-1.0" RelY="0.0" />
      <Point X="328.90212884531115" Y="276.0181094524695" GraphRef="b0bc7" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.645409949971069" Shape="None" GraphId="c183c" />
    </Graphics>
    <Xref Database="Rhea" ID="50709" />
  </Interaction>
  <Interaction GraphId="d3bfb">
    <Graphics ZOrder="32910" LineThickness="1.0">
      <Point X="151.20370370370375" Y="741.9805818689102" GraphRef="fe98b" RelX="0.0" RelY="1.0" />
      <Point X="151.20370370370375" Y="799.7222222222224" GraphRef="d7a97" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="d844b" />
    </Graphics>
    <Xref Database="Rhea" ID="48669" />
  </Interaction>
  <Interaction GraphId="f2c44">
    <Graphics ZOrder="32911" LineThickness="1.0">
      <Point X="200.67706685278927" Y="244.76010334096435" GraphRef="d5120" RelX="0.0" RelY="1.0" />
      <Point X="202.1015487405196" Y="276.0181094524695" GraphRef="c91d8" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f8b14">
    <Graphics ConnectorType="Elbow" ZOrder="32912" LineThickness="1.0">
      <Point X="714.8969691514974" Y="107.50753774497642" GraphRef="acff2" RelX="1.0" RelY="0.0" />
      <Point X="916.8518973854603" Y="141.30149555809913" />
      <Point X="1061.3958710930892" Y="175.09545337122185" GraphRef="af4a4" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.7336082177483204" Shape="None" />
    </Graphics>
    <Xref Database="Rhea" ID="38676" />
  </Interaction>
  <Interaction GraphId="bb4a4">
    <Graphics ZOrder="32913" LineThickness="1.0">
      <Point X="804.7078397624111" Y="343.4587125989633" GraphRef="c21e9" RelX="1.0" RelY="0.0" />
      <Point X="847.9305230759836" Y="335.94071524133915" GraphRef="d398f" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f8ca0">
    <Graphics ZOrder="32914" LineThickness="1.0">
      <Point X="1039.4784295893578" Y="653.3190158160754" GraphRef="a6f6f" RelX="-1.0" RelY="0.0" />
      <Point X="981.7740583825364" Y="650.0282246303191" GraphRef="e9da6" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d9c54">
    <Graphics ZOrder="32915" LineThickness="1.0">
      <Point X="151.20370370370375" Y="824.7222222222224" GraphRef="d7a97" RelX="0.0" RelY="1.0" />
      <Point X="151.2037037037038" Y="889.5343752838616" GraphRef="d6555" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="dbf26" />
    </Graphics>
    <Xref Database="Rhea" ID="48673" />
  </Interaction>
  <Interaction GraphId="ccd88">
    <Graphics ZOrder="32916" LineThickness="2.0">
      <Point X="814.1797133406836" Y="634.8640243307902" GraphRef="e4e65" RelX="0.0" RelY="1.0" />
      <Point X="815.1320942930645" Y="716.9805818689102" GraphRef="ebe00" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4213707709800799" Shape="None" GraphId="ef73d" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eb033">
    <Graphics ZOrder="32917" LineThickness="1.0">
      <Point X="202.67706685278927" Y="160.28493317132444" GraphRef="ecc29" RelX="0.0" RelY="1.0" />
      <Point X="201.30212884531124" Y="199.4" GraphRef="e82fd" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a3e67">
    <Graphics ZOrder="32918" LineThickness="1.0">
      <Point X="689.3969691514974" Y="120.00753774497642" GraphRef="acff2" RelX="0.5" RelY="1.0" />
      <Point X="679.6534225851874" Y="194.69963948527106" GraphRef="aa2bc" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="bbf29" />
    </Graphics>
    <Xref Database="Rhea" ID="17486" />
  </Interaction>
  <Interaction GraphId="efc06">
    <Graphics ZOrder="32919" LineThickness="1.0">
      <Point X="392.7754419573839" Y="214.17380856355453" GraphRef="a7bfd" RelX="-1.0" RelY="0.0" />
      <Point X="362.2976496802013" Y="216.2659374003058" GraphRef="c183c" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b46c1">
    <Graphics ZOrder="32920" LineThickness="1.0">
      <Point X="423.08277726498727" Y="107.50753774497645" GraphRef="eb655" RelX="-1.0" RelY="0.0" />
      <Point X="339.8249513370422" Y="107.50753774497642" GraphRef="b4fe0" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="c85f5" />
    </Graphics>
    <Xref Database="Rhea" ID="50217" />
  </Interaction>
  <Interaction GraphId="d8178">
    <Comment>EC:3.3.2.6</Comment>
    <Graphics ConnectorType="Elbow" ZOrder="32921" LineThickness="1.0">
      <Point X="641.4445881991164" Y="429.88448852528904" GraphRef="fec99" RelX="-0.5" RelY="-1.0" />
      <Point X="469.8080358358912" Y="313.6775156371199" GraphRef="fc694" RelX="1.0" RelY="0.0" ArrowHead="mim-catalysis" />
      <Anchor Position="0.4823758615447229" Shape="None" GraphId="ddbf5" />
    </Graphics>
    <Xref Database="Rhea" ID="22325" />
  </Interaction>
  <Interaction GraphId="e1086">
    <Graphics ZOrder="32922" LineThickness="1.0">
      <Point X="892.8295804418049" Y="207.40829243089635" GraphRef="b9f0c" RelX="-1.0" RelY="0.0" />
      <Point X="783.0223367329454" Y="207.3493229513681" GraphRef="f14d0" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e6ebb">
    <Graphics ZOrder="32923" LineThickness="1.0">
      <Point X="973.829580441805" Y="151.07581005876412" GraphRef="b31d6" RelX="0.0" RelY="1.0" />
      <Point X="972.4834760556067" Y="175.09545337122185" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ab265">
    <Graphics ZOrder="32924" LineThickness="1.0">
      <Point X="95.73167044595638" Y="957.6963340891889" GraphRef="ec997" RelX="1.0" RelY="0.0" />
      <Point X="151.20370370370378" Y="958.2917611489023" GraphRef="dba7f" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="db9ee">
    <Comment>EC:1.3.1.48</Comment>
    <Graphics ZOrder="32925" LineThickness="1.0">
      <Point X="196.20370370370372" Y="586.2809553810497" GraphRef="c6998" RelX="1.0" RelY="0.0" />
      <Point X="284.2278311545125" Y="586.2809553810497" GraphRef="a3c7d" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="c73c6" />
    </Graphics>
    <Xref Database="Rhea" ID="50609" />
  </Interaction>
  <Interaction GraphId="d1f64">
    <Graphics ZOrder="32926" LineThickness="1.0">
      <Point X="101.8133030990175" Y="665.2515117157964" GraphRef="cc54a" RelX="1.0" RelY="0.0" />
      <Point X="151.20370370370375" Y="666.530612244898" GraphRef="b4ffc" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d0cc6">
    <Graphics ZOrder="32927" LineThickness="1.0">
      <Point X="711.0261349758923" Y="249.29528937100093" GraphRef="a11a0" RelX="-1.0" RelY="0.0" />
      <Point X="663.9343080962276" Y="362.98758285014065" GraphRef="b3454" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d8b42">
    <Graphics ZOrder="32928" LineThickness="1.0">
      <Point X="981.7740583825364" Y="576.3911713928472" GraphRef="d90c5" RelX="0.0" RelY="1.0" />
      <Point X="981.7740583825364" Y="731.3707071983463" GraphRef="ced6f" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4751404942255541" Shape="None" GraphId="e9da6" />
    </Graphics>
    <Xref Database="Rhea" ID="41573" />
  </Interaction>
  <Interaction GraphId="db605">
    <Graphics ZOrder="32929" LineThickness="2.0">
      <Point X="1163.3958710930892" Y="175.09545337122185" GraphRef="af4a4" RelX="1.0" RelY="0.0" />
      <Point X="1225.6612123846971" Y="175.09545337122182" GraphRef="b6dd3" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ea857">
    <Graphics ZOrder="32930" LineThickness="1.0">
      <Point X="725.128099852251" Y="261.79528937100093" GraphRef="a11a0" RelX="-0.5" RelY="1.0" />
      <Point X="684.2103280147456" Y="360.7347038984926" GraphRef="e988e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dccf1">
    <Graphics ZOrder="32931" LineThickness="2.0">
      <Point X="872.937426415155" Y="273.3115330520393" GraphRef="c94d9" RelX="0.0" RelY="1.0" />
      <Point X="982.0534629404622" Y="428.84872417983" GraphRef="ceab3" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.697735648216573" Shape="None" GraphId="b2d23" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="aa7ec">
    <Graphics ZOrder="32932" LineThickness="2.0">
      <Point X="618.8969691514974" Y="729.4805818689102" GraphRef="c0d7f" RelX="-1.0" RelY="0.0" />
      <Point X="492.46315212716974" Y="729.4805818689102" GraphRef="dd528" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a45fc">
    <BiopaxRef>b63</BiopaxRef>
    <Graphics ZOrder="33012" LineThickness="1.0">
      <Point X="545.0" Y="442.5" GraphRef="d4c1c" RelX="0.0" RelY="1.0" />
      <Point X="556.5779062573018" Y="475.8300071939462" GraphRef="b7959" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Group GroupId="e45c2" Style="Group" />
  <Group GroupId="e01b5" GraphId="a2493" Style="Group" />
  <Group GroupId="ca6af" GraphId="a7bfd" Style="Group" />
  <Group GroupId="f1bf3" GraphId="b580a" Style="Group" />
  <Group GroupId="c3f07" GraphId="bb488" Style="Group" />
  <Group GroupId="e12ed" GraphId="c630e" Style="Group" />
  <Group GroupId="d427f" GraphId="c779c" Style="Group" />
  <Group GroupId="c2c60" GraphId="cb984" Style="Group" />
  <Group GroupId="af747" GraphId="cc54a" Style="Group" />
  <Group GroupId="d4fc5" GraphId="ec997" Style="Group" />
  <Group GroupId="cb35c" GraphId="ee9a9" Style="Group" />
  <Group GroupId="dbf2c" GraphId="f10af" Style="Group" />
  <Group GroupId="ebc03" GraphId="f7078" Style="Group" />
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">lipoxygenase mediated pathway of arachidonic acid metabolism</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000462</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b6e">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19244215</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Lipid Res</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Buczynski MW</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumlao DS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dennis EA</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dca">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26139350</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eicosanoid storm in infection and inflammation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Immunol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dennis EA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Norris PC</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f14">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18761324</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem Pharmacol</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moreno JJ</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">eicosanoid metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000485</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b63">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6321468</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1984</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee TH</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Menica-Huerta JM</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shih C</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Corey EJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lewis RA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Austen KF</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>

