<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Calcium regulation in cardiac cells" Data-Source="WikiPathways" Version="WP553_r140210" Author="[Nsalomonis, MaintBot, J.Fong, N.Cotte, Thomas, Khanspers, Christine Chichester, Egonw, Siangyun.ang, Mkutmon, Eweitz]" Last-Modified="20250807080613" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart.

Source: [Wikipedia](https://en.wikipedia.org/wiki/Calcium_signaling)</Comment>
  <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP536_r95108 WP536 (r95108)] with a 96.0% conversion rate.</Comment>
  <BiopaxRef>fbf</BiopaxRef>
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    <Xref Database="Ensembl" ID="ENSMUSG00000020882" />
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  <DataNode TextLabel="CALM1" GraphId="a23" Type="GeneProduct" GroupRef="d52f5">
    <Comment Source="HomologyMapper">No homologues found for original id L:801</Comment>
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  <DataNode TextLabel="Camk2g" GraphId="d54" Type="GeneProduct" GroupRef="ce465">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:818</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2G | calcium/calmodulin-dependent protein k..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021820" />
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  <DataNode TextLabel="ATP" GraphId="b1d" Type="Metabolite">
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    <Xref Database="CAS" ID="1927-31-7" />
  </DataNode>
  <DataNode TextLabel="Ryr2" GraphId="b6d" Type="GeneProduct" GroupRef="c4f89">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6262</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RYR2 | ryanodine receptor 2 (cardiac)" />
    <Graphics CenterX="387.40904311251313" CenterY="476.9999999999999" Width="60.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021313" />
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  <DataNode TextLabel="Rgs6" GraphId="aa2" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9628</Comment>
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  <DataNode TextLabel="Adcy4" GraphId="c01" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="GenMAPP remarks">There is no SwissProt entry for a full-length sequence in mouse.  This EST is from the Affymetrix Murine6500 chip.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:196883</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY4 | adenylate cyclase 4" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000022220" />
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  <DataNode TextLabel="Gng2" GraphId="ae4" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:54331</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG2 | guanine nucleotide binding protein (G pr..." />
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  <DataNode TextLabel="Adcy1" GraphId="eae" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="GenMAPP remarks">CYA1 HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:107</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY1 | adenylate cyclase 1 (brain)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000020431" />
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  <DataNode TextLabel="Camk2a" GraphId="cb2" Type="GeneProduct" GroupRef="ce465">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:815</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2A | calcium/calmodulin-dependent protein k..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000024617" />
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  <DataNode TextLabel="ATP" GraphId="f32" Type="Metabolite">
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    <Xref Database="CAS" ID="1927-31-7" />
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  <DataNode TextLabel="Prkcb" GraphId="db5" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5579</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCB1 | protein kinase C beta 1" />
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  <DataNode TextLabel="Epinephrine" GraphId="c26da" Type="Metabolite">
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    <Xref Database="HMDB" ID="HMDB0000068" />
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  <DataNode TextLabel="ATP" GraphId="c2e" Type="Metabolite">
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  <DataNode TextLabel="Cacna1e" GraphId="cd9" Type="GeneProduct" GroupRef="b347b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:777</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CACNA1E | calcium channel voltage-dependent a..." />
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  <DataNode TextLabel="Gng13" GraphId="f34" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:51764</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG13 | guanine nucleotide binding protein (G p..." />
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  <DataNode TextLabel="Rgs1" GraphId="e0e" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5996</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS1 | regulator of G-protein signalling 1" />
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  <DataNode TextLabel="Atp2b1" GraphId="a0b" Type="GeneProduct" GroupRef="bdeb4">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:490</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP2B1 | ATPase Ca++ transporting plasma memb..." />
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  <DataNode TextLabel="PRKACA" GraphId="cdb" Type="GeneProduct" GroupRef="dbe86">
    <Comment Source="HomologyMapper">No homologues found for original id L:5566</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKACA | protein kinase cAMP-dependent cataly..." />
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  <DataNode TextLabel="Na⁺" GraphId="b45a2" Type="Metabolite">
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  <DataNode TextLabel="Gnai2" GraphId="a58" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2771</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAI2 | guanine nucleotide binding protein (G p..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000032562" />
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  <DataNode TextLabel="Atp2a3" GraphId="e87" Type="GeneProduct" GroupRef="f6aeb">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:489</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP2A3 | ATPase Ca++ transporting ubiquitous" />
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  <DataNode TextLabel="Atp2b3" GraphId="cad" Type="GeneProduct" GroupRef="bdeb4">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:492</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP2B3 | ATPase Ca++ transporting plasma memb..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000031376" />
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  <DataNode TextLabel="Acetylcholine" GraphId="ae8" Type="Metabolite">
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    <Xref Database="CAS" ID="51-84-3" />
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  <DataNode TextLabel="Gja5" GraphId="c64" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2702</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA5 | gap junction protein alpha 5 40kDa (co..." />
    <Graphics CenterX="320.0" CenterY="930.0" Width="60.0" Height="20.0" ZOrder="32816" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000057123" />
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  <DataNode TextLabel="Plcb3" GraphId="c43" Type="GeneProduct" GroupRef="fe49e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCB3 | phospholipase C beta 3 (phosphatidylin..." />
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  <DataNode TextLabel="Adra1a" GraphId="c8a" Type="GeneProduct" GroupRef="c6ea6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:148</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADRA1A | adrenergic alpha-1A- receptor" />
    <Graphics CenterX="971.0000000000016" CenterY="145.07570977917982" Width="60.0" Height="20.0" ZOrder="32820" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000045875" />
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  <DataNode TextLabel="Gnb4" GraphId="bbf" Type="GeneProduct" GroupRef="e805b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59345</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB4 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000027669" />
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  <DataNode TextLabel="Pln" GraphId="c5b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5350</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLN | phospholamban" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000038583" />
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  <DataNode TextLabel="Rgs20" GraphId="da1" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8601</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS20 | regulator of G-protein signalling 20" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000002459" />
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  <DataNode TextLabel="GJA10" GraphId="d9f" Type="GeneProduct">
    <Comment Source="HomologyMapper">No homologues found for original id L:81025</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA10 | gap junction protein alpha 10 59kDa" />
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="CALM2" GraphId="b22" Type="GeneProduct" GroupRef="d52f5">
    <Comment Source="HomologyMapper">Multiple homologues found: En:ENSMUSG00000019370;En:ENSMUSG00000019370;</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALM2 | calmodulin 2 (phosphorylase kinase del..." />
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  <DataNode TextLabel="Prkacb" GraphId="e75" Type="GeneProduct" GroupRef="dbe86">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5567</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKACB | protein kinase cAMP-dependent cataly..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000005034" />
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6261</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RYR1 | ryanodine receptor 1 (skeletal)" />
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  <DataNode TextLabel="Camk4" GraphId="b70" Type="GeneProduct" GroupRef="ce465">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:814</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK4 | calcium/calmodulin-dependent protein ki..." />
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  <DataNode TextLabel="Pi" GraphId="e5d44" Type="Metabolite" GroupRef="e75ca">
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    <Xref Database="HMDB" ID="HMDB0001429" />
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  <DataNode TextLabel="Adcy5" GraphId="b80" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="GenMAPP remarks">There is no SwissProt entry for a full-length sequence in mouse.  This EST is from the Affymetrix Murine6500 chip.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:111</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY5 | adenylate cyclase 5" />
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  <DataNode TextLabel="Pkib" GraphId="f1f" Type="GeneProduct" GroupRef="b3d70">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5570</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PKIB | protein kinase (cAMP-dependent catalyti..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000019876" />
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  <DataNode TextLabel="Arrb2" GraphId="c10" Type="GeneProduct" GroupRef="f86b6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB2 | arrestin beta 2" />
    <Graphics CenterX="1376.6666666666667" CenterY="496.6666666666667" Width="60.0" Height="20.0" ZOrder="32844" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000060216" />
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  <DataNode TextLabel="Rgs10" GraphId="dd6" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6001</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS10 | regulator of G-protein signalling 10" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000030844" />
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  <DataNode TextLabel="Adra1d" GraphId="a07" Type="GeneProduct" GroupRef="c6ea6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:146</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADRA1D | adrenergic alpha-1D- receptor" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000027335" />
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  <DataNode TextLabel="Adrb1" GraphId="cc1" Type="GeneProduct" GroupRef="e9d93">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:153</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADRB1 | adrenergic beta-1- receptor" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000035283" />
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  <DataNode TextLabel="Rgs14" GraphId="e39" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10636</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS14 | regulator of G-protein signalling 14" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000052087" />
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    <Xref Database="ChEBI" ID="CHEBI:16783" />
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  <DataNode TextLabel="DAG" GraphId="caa32" Type="Metabolite">
    <Comment>DAG = aspartate-alanine-glycine</Comment>
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="Cacna1s" GraphId="a68" Type="GeneProduct" GroupRef="e6d4f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:779</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CACNA1S | calcium channel voltage-dependent L..." />
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  <DataNode TextLabel="Chrm4" GraphId="c77" Type="GeneProduct" GroupRef="b0644">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1132</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CHRM4 | cholinergic receptor muscarinic 4" />
    <Graphics CenterX="290.8727655099894" CenterY="152.38485804416405" Width="60.0" Height="20.0" ZOrder="32860" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000040495" />
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  <DataNode TextLabel="Chrm2" GraphId="f7c" Type="GeneProduct" GroupRef="e8236">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1129</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CHRM2 | cholinergic receptor muscarinic 2" />
    <Graphics CenterX="194.20609884332282" CenterY="172.38485804416405" Width="60.0" Height="20.0" ZOrder="32862" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000045613" />
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  <DataNode TextLabel="Cacna1c" GraphId="ad8" Type="GeneProduct" GroupRef="e6d4f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:775</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CACNA1C | calcium channel voltage-dependent L..." />
    <Graphics CenterX="392.63932702418487" CenterY="147.07570977917982" Width="66.66666666666667" Height="20.0" ZOrder="32864" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000051331" />
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  <DataNode TextLabel="IP3" GraphId="a033e" Type="Metabolite">
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    <Xref Database="Chemspider" ID="388562" />
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  <DataNode TextLabel="Gjc1" GraphId="ced" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10052</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA7 | gap junction protein alpha 7 45kDa (co..." />
    <Graphics CenterX="320.0" CenterY="948.5809906291834" Width="60.0" Height="20.0" ZOrder="32868" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000034520" />
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  <DataNode TextLabel="Kcnb1" GraphId="ad0" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3745</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="KCNB1 | potassium voltage-gated channel Shab-r..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000050556" />
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  <DataNode TextLabel="Adcy2" GraphId="b8a" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="GenMAPP remarks">There is no SwissProt entry for a full-length sequence in mouse.  This EST is from the Affymetrix Murine6500 chip.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:108</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY2 | adenylate cyclase 2 (brain)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021536" />
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  <DataNode TextLabel="Gja1" GraphId="d2d" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2697</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA1 | gap junction protein alpha 1 43kDa (co..." />
    <Graphics CenterX="320.0" CenterY="870.0" Width="60.0" Height="20.0" ZOrder="32874" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000050953" />
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  <DataNode TextLabel="Itpr2" GraphId="efb" Type="GeneProduct" GroupRef="d9bb1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3709</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITPR2 | inositol 145-triphosphate receptor t..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000030287" />
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  <DataNode TextLabel="Prkar1b" GraphId="cff" Type="GeneProduct" GroupRef="dbe86">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5575</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKAR1B | protein kinase cAMP-dependent regul..." />
    <Graphics CenterX="1123.7810945273634" CenterY="206.41293532338307" Width="66.66666666666667" Height="20.0" ZOrder="32878" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025855" />
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  <DataNode TextLabel="Cacna1d" GraphId="ef7" Type="GeneProduct" GroupRef="e6d4f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:776</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CACNA1D | calcium channel voltage-dependent L..." />
    <Graphics CenterX="392.63932702418487" CenterY="167.07570977917982" Width="66.66666666666667" Height="20.0" ZOrder="32880" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000015968" />
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  <DataNode TextLabel="Camk2d" GraphId="eeb" Type="GeneProduct" GroupRef="ce465">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:817</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2D | calcium/calmodulin-dependent protein k..." />
    <Graphics CenterX="1143.9303482587072" CenterY="324.07960199004975" Width="60.0" Height="20.0" ZOrder="32882" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000053819" />
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  <DataNode TextLabel="Gnb3" GraphId="d14" Type="GeneProduct" GroupRef="e805b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2784</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB3 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="1133.482587064677" CenterY="512.5870646766169" Width="60.0" Height="20.0" ZOrder="32884" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000023439" />
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  <DataNode TextLabel="Cacna1a" GraphId="e18" Type="GeneProduct" GroupRef="b347b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:773</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CACNA1A | calcium channel voltage-dependent P..." />
    <Graphics CenterX="482.63932702418487" CenterY="148.07570977917982" Width="66.66666666666667" Height="20.0" ZOrder="32886" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000034656" />
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  <DataNode TextLabel="Kcnj3" GraphId="d23" Type="GeneProduct" GroupRef="d2fb6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3760</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="KCNJ3 | potassium inwardly-rectifying channel ..." />
    <Graphics CenterX="93.69085173501577" CenterY="274.79390115667707" Width="60.0" Height="20.0" ZOrder="32888" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026824" />
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  <DataNode TextLabel="Rgs5" GraphId="a35" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8490</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS5 | regulator of G-protein signalling 5" />
    <Graphics CenterX="1342.6865671641795" CenterY="144.42786069651743" Width="60.0" Height="20.0" ZOrder="32890" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026678" />
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  <DataNode TextLabel="Ywhab" GraphId="aed" Type="GeneProduct" GroupRef="f9c5e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7529</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAB | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1341.6865671641795" CenterY="261.58706467661693" Width="60.0" Height="20.0" ZOrder="32892" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018326" />
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  <DataNode TextLabel="Gnb5" GraphId="c9f" Type="GeneProduct" GroupRef="e805b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10681</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB5 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="1193.6318407960196" CenterY="492.5870646766169" Width="60.0" Height="20.0" ZOrder="32894" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032192" />
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  <DataNode TextLabel="Kcnj5" GraphId="df0" Type="GeneProduct" GroupRef="d2fb6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3762</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="KCNJ5 | potassium inwardly-rectifying channel ..." />
    <Graphics CenterX="93.69085173501577" CenterY="294.79390115667707" Width="60.0" Height="20.0" ZOrder="32896" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032034" />
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  <DataNode TextLabel="ADP" GraphId="f91" Type="Metabolite">
    <Graphics CenterX="773.3333333333334" CenterY="570.0" Width="29.333333333333332" Height="15.0" ZOrder="32898" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="58-64-0" />
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  <DataNode TextLabel="Ywhaz" GraphId="dc9" Type="GeneProduct" GroupRef="f9c5e">
    <Comment Source="GenMAPP remarks">PMID: 9861170 PMID: 1317796</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7534</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1401.835820895522" CenterY="302.3333333333333" Width="60.0" Height="20.0" ZOrder="32900" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022285" />
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  <DataNode TextLabel="Ywhah" GraphId="ea1" Type="GeneProduct" GroupRef="f9c5e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7533</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAH | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1341.6865671641795" CenterY="301.5870646766169" Width="60.0" Height="20.0" ZOrder="32902" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018965" />
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  <DataNode TextLabel="Gja3" GraphId="e49" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2700</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA3 | gap junction protein alpha 3 46kDa (co..." />
    <Graphics CenterX="320.0" CenterY="890.0" Width="60.0" Height="20.0" ZOrder="32904" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000048582" />
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  <DataNode TextLabel="Itpr1" GraphId="e77" Type="GeneProduct" GroupRef="d9bb1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3708</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITPR1 | inositol 145-triphosphate receptor t..." />
    <Graphics CenterX="814.384858044164" CenterY="427.8212407991588" Width="53.333333333333336" Height="20.0" ZOrder="32906" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030102" />
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  <DataNode TextLabel="Atp2b2" GraphId="d87" Type="GeneProduct" GroupRef="bdeb4">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:491</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP2B2 | ATPase Ca++ transporting plasma memb..." />
    <Graphics CenterX="728.7244897959182" CenterY="685.8979591836734" Width="60.0" Height="20.0" ZOrder="32908" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030302" />
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  <DataNode TextLabel="Gjb3" GraphId="d08" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2707</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJB3 | gap junction protein beta 3 31kDa (con..." />
    <Graphics CenterX="500.0" CenterY="910.0" Width="60.0" Height="20.0" ZOrder="32910" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000042367" />
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  <DataNode TextLabel="Gjb4" GraphId="aa9" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:127534</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJB4 | gap junction protein beta 4 (connexin 3..." />
    <Graphics CenterX="500.0" CenterY="930.0" Width="60.0" Height="20.0" ZOrder="32912" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000046623" />
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  <DataNode TextLabel="Sfn" GraphId="efd" Type="GeneProduct" GroupRef="f9c5e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2810</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SFN | stratifin" />
    <Graphics CenterX="1401.835820895522" CenterY="262.33333333333326" Width="60.0" Height="20.0" ZOrder="32914" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000047281" />
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  <DataNode TextLabel="Prkd1" GraphId="c54" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="GenMAPP remarks">KPCM HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5587</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKD1 | protein kinase D1" />
    <Graphics CenterX="1406.9154228855716" CenterY="594.0796019900498" Width="60.0" Height="20.0" ZOrder="32916" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000002688" />
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  <DataNode TextLabel="Gng12" GraphId="e47" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:55970</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG12 | guanine nucleotide binding protein (G p..." />
    <Graphics CenterX="1193.7263681592037" CenterY="623.1741293532338" Width="60.0" Height="20.0" ZOrder="32918" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000036402" />
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  <DataNode TextLabel="Gnaq" GraphId="e6b" Type="GeneProduct" GroupRef="f2fc9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2776</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAQ | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="969.9999999999998" CenterY="248.28180862250264" Width="60.0" Height="20.0" ZOrder="32920" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024639" />
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  <DataNode TextLabel="Gng11" GraphId="d50" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2791</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG11 | guanine nucleotide binding protein (G p..." />
    <Graphics CenterX="1193.7263681592037" CenterY="603.1741293532338" Width="60.0" Height="20.0" ZOrder="32922" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032766" />
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  <DataNode TextLabel="Prkcd" GraphId="b34" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5580</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCD | protein kinase C delta" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021948" />
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  <DataNode TextLabel="Gng7" GraphId="c15" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2788</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG7 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000048240" />
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  <DataNode TextLabel="Gjb6" GraphId="cd2" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10804</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJB6 | gap junction protein beta 6 (connexin 3..." />
    <Graphics CenterX="500.0" CenterY="970.0" Width="60.0" Height="20.0" ZOrder="32928" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000040055" />
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  <DataNode TextLabel="Gnai3" GraphId="da8" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2773</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAI3 | guanine nucleotide binding protein (G p..." />
    <Graphics CenterX="1160.0" CenterY="743.3333333333334" Width="60.0" Height="20.0" ZOrder="32930" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000000001" />
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  <DataNode TextLabel="Prkce" GraphId="ed6" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="GenMAPP remarks">This EST is listed on the Affymetrix Murine6500 chip.  The SwissProt entry name is KPCE MOUSE.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5581</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCE | protein kinase C epsilon" />
    <Graphics CenterX="1347.9104477611945" CenterY="634.8258706467662" Width="60.0" Height="20.0" ZOrder="32932" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000045038" />
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  <DataNode TextLabel="Rgs18" GraphId="c34" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:64407</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS18 | regulator of G-protein signalling 18" />
    <Graphics CenterX="1402.835820895522" CenterY="162.9353233830846" Width="60.0" Height="20.0" ZOrder="32934" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026357" />
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  <DataNode TextLabel="Rgs7" GraphId="aab" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6000</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS7 | regulator of G-protein signalling 7" />
    <Graphics CenterX="1342.6865671641795" CenterY="184.42786069651743" Width="60.0" Height="20.0" ZOrder="32936" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026527" />
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  <DataNode TextLabel="K⁺" GraphId="b4df6" Type="Metabolite">
    <Graphics CenterX="23.239495798319325" CenterY="289.0168067226892" Width="30.54621848739496" Height="20.0" ZOrder="32938" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000586" />
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  <DataNode TextLabel="Grk5" GraphId="f5d" Type="GeneProduct" GroupRef="b3174">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK5 | G protein-coupled receptor kinase 5" />
    <Graphics CenterX="1327.6666666666667" CenterY="400.0" Width="60.0" Height="20.0" ZOrder="32940" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000003228" />
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  <DataNode TextLabel="Gng8" GraphId="e20" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:94235</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG8 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000063594" />
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  <DataNode TextLabel="Pkia" GraphId="f71" Type="GeneProduct" GroupRef="b3d70">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5569</Comment>
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  <DataNode TextLabel="Ryr3" GraphId="f0f" Type="GeneProduct" GroupRef="c4f89">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6263</Comment>
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  <DataNode TextLabel="Itpr3" GraphId="d00" Type="GeneProduct" GroupRef="d9bb1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3710</Comment>
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  <DataNode TextLabel="Adcy8" GraphId="fcb" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:114</Comment>
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  <DataNode TextLabel="Chrm1" GraphId="aba" Type="GeneProduct" GroupRef="e8236">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1128</Comment>
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  <DataNode TextLabel="Rgs19" GraphId="c8b" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10287</Comment>
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  <DataNode TextLabel="Adra1b" GraphId="e04" Type="GeneProduct" GroupRef="c6ea6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:147</Comment>
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  <DataNode TextLabel="Calm3" GraphId="a7e" Type="GeneProduct" GroupRef="d52f5">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:808</Comment>
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  <DataNode TextLabel="Fkbp1a" GraphId="c95" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2280</Comment>
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  <DataNode TextLabel="Gjb1" GraphId="f7b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2705</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJB1 | gap junction protein beta 1 32kDa (con..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000047797" />
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  <DataNode TextLabel="Gja8" GraphId="a38" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2703</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA8 | gap junction protein alpha 8 50kDa (co..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000049908" />
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  <DataNode TextLabel="Rgs17" GraphId="b84" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:26575</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS17 | regulator of G-protein signalling 17" />
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  <DataNode TextLabel="Casq1" GraphId="de646" Type="GeneProduct" GroupRef="b4122">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:844</Comment>
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  <DataNode TextLabel="Adcy3" GraphId="b60" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:109</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY3 | adenylate cyclase 3" />
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  <DataNode TextLabel="Ywhae" GraphId="bf4" Type="GeneProduct" GroupRef="f9c5e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7531</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAE | tyrosine 3-monooxygenase/tryptophan 5-m..." />
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  <DataNode TextLabel="cAMP" GraphId="d19c8" Type="Metabolite">
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  <DataNode TextLabel="Anxa6" GraphId="ca8" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:309</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ANXA6 | annexin A6" />
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  <DataNode TextLabel="Gna11" GraphId="bc4" Type="GeneProduct" GroupRef="f2fc9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2767</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNA11 | guanine nucleotide binding protein (G p..." />
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  <DataNode TextLabel="Gng5" GraphId="fa0" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2787</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG5 | guanine nucleotide binding protein (G pr..." />
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  <DataNode TextLabel="Adcy9" GraphId="c16" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:115</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY9 | adenylate cyclase 9" />
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  <DataNode TextLabel="Rgs16" GraphId="cf1" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6004</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS16 | regulator of G-protein signalling 16" />
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  <DataNode TextLabel="Slc8a1" GraphId="cf0" Type="GeneProduct" GroupRef="f2058">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6546</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SLC8A1 | solute carrier family 8 (sodium/calciu..." />
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  <DataNode TextLabel="Ywhaq" GraphId="b95" Type="GeneProduct" GroupRef="f9c5e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10971</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-m..." />
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  <DataNode TextLabel="Adcy7" GraphId="a90" Type="GeneProduct" GroupRef="c4b3c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:113</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY7 | adenylate cyclase 7" />
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  <DataNode TextLabel="Gnaz" GraphId="f66" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2781</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAZ | guanine nucleotide binding protein (G pr..." />
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  <DataNode TextLabel="Plcb3" GraphId="e7c" Type="GeneProduct" GroupRef="fe49e">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCB3 | phospholipase C beta 3 (phosphatidylin..." />
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  <DataNode TextLabel="Adrb3" GraphId="a7a" Type="GeneProduct" GroupRef="e9d93">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:155</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADRB3 | adrenergic beta-3- receptor" />
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  <DataNode TextLabel="Gjb5" GraphId="b04" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2709</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJB5 | gap junction protein beta 5 (connexin 3..." />
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  <DataNode TextLabel="PIP2" GraphId="b40cc" Type="Metabolite">
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  <DataNode TextLabel="Calr" GraphId="f92ea" Type="GeneProduct" GroupRef="b4122">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:811</Comment>
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  <DataNode TextLabel="Rgs11" GraphId="b92" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8786</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS11 | regulator of G-protein signalling 11" />
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  <DataNode TextLabel="Casq1" GraphId="e2a" Type="GeneProduct" GroupRef="f9f41">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:844</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASQ1 | calsequestrin 1 (fast-twitch skeletal ..." />
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  <DataNode TextLabel="Gngt1" GraphId="af1" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2792</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNGT1 | guanine nucleotide binding protein (G p..." />
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  <DataNode TextLabel="Prkcz" GraphId="d64" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5590</Comment>
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  <DataNode TextLabel="Prkar1a" GraphId="c38" Type="GeneProduct" GroupRef="dbe86">
    <Comment Source="GenMAPP remarks">KAP0 HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5573</Comment>
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  <DataNode TextLabel="Gnb2" GraphId="aaa" Type="GeneProduct" GroupRef="e805b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2783</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB2 | guanine nucleotide binding protein (G pr..." />
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  <DataNode TextLabel="Pkig" GraphId="ddf" Type="GeneProduct" GroupRef="b3d70">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11142</Comment>
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  <DataNode TextLabel="Rgs4" GraphId="a89" Type="GeneProduct" GroupRef="aed98">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5999</Comment>
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  <DataNode TextLabel="Prkch" GraphId="a4a" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5583</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCH | protein kinase C eta" />
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  <DataNode TextLabel="Prkar2b" GraphId="e7e" Type="GeneProduct" GroupRef="dbe86">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5577</Comment>
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  <DataNode TextLabel="Prkcq" GraphId="c89" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5588</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCQ | protein kinase C theta" />
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  <DataNode TextLabel="Gng3" GraphId="c74" Type="GeneProduct" GroupRef="ced50">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2785</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG3 | guanine nucleotide binding protein (G pr..." />
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  <DataNode TextLabel="Prkca" GraphId="c42" Type="GeneProduct" GroupRef="d4570">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5578</Comment>
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  <DataNode TextLabel="Gjc2" GraphId="fd3" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:57165</Comment>
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