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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Matrix metalloproteinases" Data-Source="WikiPathways" Version="WP441_r137002" Author="[Kdahlquist, MaintBot, M.Braymer, Khanspers, Thomas, Ddigles, Eweitz]" Last-Modified="20250226203032" Organism="Mus musculus">
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP129&amp;amp;amp;amp;oldid=20953 WP129(r20953)] with a 93% conversion rate.</Comment>
  <Comment Source="WikiPathways-description">Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.
Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: [Wikipedia](https://en.wikipedia.org/wiki/Matrix_metalloproteinase)</Comment>
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