<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Type II interferon signaling (IFNG)" Data-Source="WikiPathways" Version="WP1253_r142075" Author="[MaintBot, Chaodc, AlexanderPico, Khanspers, Ddigles, Mkutmon, Egonw]" Last-Modified="20251201070131" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes.</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP619&amp;amp;amp;amp;oldid=28124 WP619(r28124)] with a 92% conversion rate.</Comment>
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