<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Integrin-mediated cell adhesion" Data-Source="WikiPathways" Version="WP6_r136997" Author="[169.230.77.174, MaintBot, Thomas, Ddigles, AlexanderPico, Mkutmon, DeSl, Eweitz, Khanspers]" Last-Modified="20250226202724" Organism="Mus musculus">
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP185&amp;amp;oldid=21067 WP185(r21067)] with a 94% conversion rate.</Comment>
  <Comment Source="WikiPathways-description">Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle.

Source: [Wikipedia](https://en.wikipedia.org/wiki/Integrin)
</Comment>
  <BiopaxRef>a22</BiopaxRef>
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  <DataNode TextLabel="Capn9" GraphId="a13" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17</Comment>
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  <DataNode TextLabel="Actn1" GraphId="a16" Type="GeneProduct">
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    <Xref Database="Entrez Gene" ID="109711" />
  </DataNode>
  <DataNode TextLabel="Ilk" GraphId="a25" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">ILK; integrin-linked kinase [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ilk" />
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    <Xref Database="Entrez Gene" ID="16202" />
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  <DataNode TextLabel="Ptk2" GraphId="a2d" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ptk2" />
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  </DataNode>
  <DataNode TextLabel="Itgb3" GraphId="a3c" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb3" />
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  <DataNode TextLabel="Itgae" GraphId="a48" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgae" />
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  </DataNode>
  <DataNode TextLabel="Sos1" GraphId="a4d" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SOS1; son of sevenless homolog 1 (Drosophila)</Comment>
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  </DataNode>
  <DataNode TextLabel="Zyx" GraphId="a66" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">ZYX; zyxin</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Zyx" />
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  <DataNode TextLabel="Rap1a" GraphId="a71" Type="GeneProduct" GroupRef="ace1c">
    <Comment Source="GenMAPP remarks">RAP1A; RAP1A  member of RAS oncogene family</Comment>
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  <DataNode TextLabel="Itgam" GraphId="a75" Type="GeneProduct">
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  </DataNode>
  <DataNode TextLabel="Crk" GraphId="a80" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CRK; v-crk sarcoma virus CT10 oncogene homolog (avian</Comment>
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  <DataNode TextLabel="Itga7" GraphId="a85" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga7" />
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  <DataNode TextLabel="Itgb7" GraphId="aaa" Type="GeneProduct">
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  <DataNode TextLabel="MYO-P" GraphId="ab0" Type="GeneProduct">
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  <DataNode TextLabel="Capn5" GraphId="ac4" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN5; calpain</Comment>
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  <DataNode TextLabel="Itgad" GraphId="acd" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgad" />
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  <DataNode TextLabel="Sepp1" GraphId="ae2" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SEPP1; selenoprotein P  plasma</Comment>
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  <DataNode TextLabel="Rock1" GraphId="ae6" Type="GeneProduct" GroupRef="e1eeb">
    <Comment Source="GenMAPP remarks">ROCK1; Rho-associated  coiled-coil containing protein kinase</Comment>
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  <DataNode TextLabel="Itgav" GraphId="b01" Type="GeneProduct">
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  <DataNode TextLabel="Itga3" GraphId="b06" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga3" />
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  <DataNode TextLabel="Vcl" GraphId="b0b" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">VCL; vinculin</Comment>
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  <DataNode TextLabel="Rapgef1" GraphId="b19" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene</Comment>
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  <DataNode TextLabel="Itga2b" GraphId="b20" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga2b" />
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  <DataNode TextLabel="Capn6" GraphId="b75" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN6; calpain 6 [EC:3.4.22.17]</Comment>
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  <DataNode TextLabel="Rac2" GraphId="bbf" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">RAC2; ras-related C3 botulinum toxin substrate 2 (rho family  small GTP binding protein Rac2)</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rac2" />
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  <DataNode TextLabel="Pxn" GraphId="bda" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PXN; paxillin</Comment>
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  <DataNode TextLabel="Pak6" GraphId="c2b" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PAK6; p21(CDKN1A)-activated kinase</Comment>
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  <DataNode TextLabel="Map2k1" GraphId="c2f" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]</Comment>
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  <DataNode TextLabel="Bcar1" GraphId="c36" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">BCAR1; breast cancer anti-estrogen resistance 1</Comment>
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  <DataNode TextLabel="Itgb4" GraphId="c57" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb4" />
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  <DataNode TextLabel="Itgb8" GraphId="ca1" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb8" />
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  <DataNode TextLabel="Pdpk1" GraphId="cad" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pdpk1" />
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  <DataNode TextLabel="Capn3" GraphId="cb5" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN3; calpain 3  (p94) [EC:3.4.22.17]</Comment>
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    <Xref Database="Entrez Gene" ID="12335" />
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  <DataNode TextLabel="Src" GraphId="cc0" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]</Comment>
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  <DataNode TextLabel="Dock1" GraphId="cd0" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">DOCK1; dedicator of cyto-kinesis</Comment>
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  <DataNode TextLabel="Vav3" GraphId="cd2" Type="GeneProduct" GroupRef="d5b16">
    <Comment Source="GenMAPP remarks">VAV3; vav 3 oncogene</Comment>
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  <DataNode TextLabel="Braf" GraphId="cde" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]</Comment>
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  <DataNode TextLabel="Cav2" GraphId="cf0" Type="GeneProduct" GroupRef="feaf9">
    <Comment Source="GenMAPP remarks">CAV2; caveolin 2</Comment>
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  <DataNode TextLabel="Itgal" GraphId="d01" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgal" />
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  <DataNode TextLabel="Araf" GraphId="d05" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]</Comment>
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    <Comment Source="GenMAPP remarks">CAPN11; calpain 11 [EC:3.4.22.17]</Comment>
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  <DataNode TextLabel="Capn10" GraphId="d15" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN10; calpain 10 [EC:3.4.22.17</Comment>
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  <DataNode TextLabel="Itgax" GraphId="d16" Type="GeneProduct">
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  <DataNode TextLabel="Itga1" GraphId="d1b" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga1" />
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    <Xref Database="Entrez Gene" ID="109700" />
  </DataNode>
  <DataNode TextLabel="Fyn" GraphId="d21" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">FYN; FYN oncogene related to SRC  FGR  YES [EC:2.7.1.112]</Comment>
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  <DataNode TextLabel="Mapk10" GraphId="d24" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk10" />
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  <DataNode TextLabel="Csk" GraphId="d4e" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CSK; c-src tyrosine kinase [EC:2.7.1.112]</Comment>
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  <DataNode TextLabel="Cav3" GraphId="d4f" Type="GeneProduct" GroupRef="feaf9">
    <Comment Source="GenMAPP remarks">CAV3; caveolin 3</Comment>
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  </DataNode>
  <DataNode TextLabel="Rho" GraphId="d5d" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">RHO; rhodopsin (opsin 2  rod pigment) (retinitis pigmentosa 4  autosomal dominant)</Comment>
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  <DataNode TextLabel="Hras1" GraphId="d66" Type="GeneProduct">
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  </DataNode>
  <DataNode TextLabel="Mapk7" GraphId="d6b" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk7" />
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  </DataNode>
  <DataNode TextLabel="Cav1" GraphId="d79" Type="GeneProduct" GroupRef="feaf9">
    <Comment Source="GenMAPP remarks">CAV1; caveolin 1  caveolae protein  22kD</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cav1" />
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    <Xref Database="Entrez Gene" ID="12389" />
  </DataNode>
  <DataNode TextLabel="Itgb6" GraphId="d80" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb6" />
    <Graphics CenterX="970.0" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16420" />
  </DataNode>
  <DataNode TextLabel="Mapk6" GraphId="d81" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk6" />
    <Graphics CenterX="596.6666666666666" CenterY="510.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="50772" />
  </DataNode>
  <DataNode TextLabel="Shc1" GraphId="d86" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SHC1; SHC (Src homology 2 domain containing) transforming protein 1</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Shc1" />
    <Graphics CenterX="200.0" CenterY="340.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20416" />
  </DataNode>
  <DataNode TextLabel="Itgb1" GraphId="d8c" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb1" />
    <Graphics CenterX="970.0" CenterY="560.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16412" />
  </DataNode>
  <DataNode TextLabel="Capn2" GraphId="d8d" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN2; calpain 2  (m/II) large subunit [EC:3.4.22.17]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Capn2" />
    <Graphics CenterX="106.66666666666667" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12334" />
  </DataNode>
  <DataNode TextLabel="Akt3" GraphId="d90" Type="GeneProduct" GroupRef="c03b0">
    <Comment Source="GenMAPP remarks">AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B  gamma) [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt3" />
    <Graphics CenterX="900.0" CenterY="306.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="23797" />
  </DataNode>
  <DataNode TextLabel="Map2k2" GraphId="d9b" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Map2k2" />
    <Graphics CenterX="496.6666666666667" CenterY="490.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="26396" />
  </DataNode>
  <DataNode TextLabel="Pik3r2" GraphId="da5" Type="GeneProduct" GroupRef="de408">
    <Comment Source="GenMAPP remarks">PIK3R2; phosphoinositide-3-kinase  regulatory subunit  polypeptide 2 (p85 beta)</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r2" />
    <Graphics CenterX="470.0" CenterY="266.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18709" />
  </DataNode>
  <DataNode TextLabel="Itga9" GraphId="dab" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga9" />
    <Graphics CenterX="796.6666666666666" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="104099" />
  </DataNode>
  <DataNode TextLabel="Tns1" GraphId="dc1" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">TNS; tensi</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Tns1" />
    <Graphics CenterX="340.0" CenterY="126.66666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="21961" />
  </DataNode>
  <DataNode TextLabel="Capn7" GraphId="dc7" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN7; calpain 7 [EC:3.4.22.17</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Capn7" />
    <Graphics CenterX="200.0" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12339" />
  </DataNode>
  <DataNode TextLabel="Itga5" GraphId="dc8" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga5" />
    <Graphics CenterX="720.0" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16402" />
  </DataNode>
  <DataNode TextLabel="Itga10" GraphId="dcb" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga10" />
    <Graphics CenterX="796.6666666666666" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="213119" />
  </DataNode>
  <DataNode TextLabel="Raf1" GraphId="dd7" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Raf1" />
    <Graphics CenterX="396.6666666666667" CenterY="470.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="110157" />
  </DataNode>
  <DataNode TextLabel="Vav2" GraphId="de7" Type="GeneProduct" GroupRef="d5b16">
    <Comment Source="GenMAPP remarks">VAV2; vav 2 oncogene</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Vav2" />
    <Graphics CenterX="710.0" CenterY="203.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22325" />
  </DataNode>
  <DataNode TextLabel="Cdc42" GraphId="e0a" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CDC42; cell division cycle 42 (GTP binding protein  25kD)</Comment>
    <Graphics CenterX="710.0" CenterY="170.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12540" />
  </DataNode>
  <DataNode TextLabel="Map2k5" GraphId="e0d" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Map2k5" />
    <Graphics CenterX="496.6666666666667" CenterY="530.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="23938" />
  </DataNode>
  <DataNode TextLabel="Capns1" GraphId="e13" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPNS1; calpain  small subunit 1 [EC:3.4.22.17]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Capns1" />
    <Graphics CenterX="206.66666666666666" CenterY="223.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12336" />
  </DataNode>
  <DataNode TextLabel="Itgb2" GraphId="e20" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb2" />
    <Graphics CenterX="970.0" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16414" />
  </DataNode>
  <DataNode TextLabel="Pak2" GraphId="e2e" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pak2" />
    <Graphics CenterX="293.3333333333333" CenterY="596.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="224105" />
  </DataNode>
  <DataNode TextLabel="Map2k3" GraphId="e47" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Map2k3" />
    <Graphics CenterX="496.6666666666667" CenterY="510.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="26397" />
  </DataNode>
  <DataNode TextLabel="Mapk1" GraphId="e4d" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk1" />
    <Graphics CenterX="596.6666666666666" CenterY="470.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="26413" />
  </DataNode>
  <DataNode TextLabel="Sorbs1" GraphId="e65" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SH3D5; SH3-domain protein 5 (ponsin</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Sorbs1" />
    <Graphics CenterX="306.6666666666667" CenterY="80.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20411" />
  </DataNode>
  <DataNode TextLabel="PI5K" GraphId="e6a" Type="GeneProduct">
    <Graphics CenterX="550.0" CenterY="326.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Rap1b" GraphId="e6b" Type="GeneProduct" GroupRef="ace1c">
    <Comment Source="GenMAPP remarks">RAP1B; RAP1B  member of RAS oncogene family</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rap1b" />
    <Graphics CenterX="800.0" CenterY="80.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="215449" />
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  <DataNode TextLabel="Src" GraphId="e72" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Src" />
    <Graphics CenterX="523.3333333333334" CenterY="120.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20779" />
  </DataNode>
  <DataNode TextLabel="Map2k6" GraphId="ea6" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Map2k6" />
    <Graphics CenterX="496.6666666666667" CenterY="550.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="26399" />
  </DataNode>
  <DataNode TextLabel="Pak3" GraphId="eac" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pak3" />
    <Graphics CenterX="293.3333333333333" CenterY="616.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18481" />
  </DataNode>
  <DataNode TextLabel="Itga2" GraphId="ece" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga2" />
    <Graphics CenterX="720.0" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16398" />
  </DataNode>
  <DataNode TextLabel="Akt2" GraphId="ecf" Type="GeneProduct" GroupRef="c03b0">
    <Comment Source="GenMAPP remarks">AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt2" />
    <Graphics CenterX="900.0" CenterY="286.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11652" />
  </DataNode>
  <DataNode TextLabel="Capn1" GraphId="ed3" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CAPN1; calpain 1  (mu/I) large subunit [EC:3.4.22.17]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Capn1" />
    <Graphics CenterX="106.66666666666667" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12333" />
  </DataNode>
  <DataNode TextLabel="Rac1" GraphId="ed7" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">RAC1; ras-related C3 botulinum toxin substrate 1 (rho family  small GTP binding protein Rac1)</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rac1" />
    <Graphics CenterX="830.0" CenterY="193.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="19353" />
  </DataNode>
  <DataNode TextLabel="Rock2" GraphId="ede" Type="GeneProduct" GroupRef="e1eeb">
    <Comment Source="GenMAPP remarks">ROCK2; Rho-associated  coiled-coil containing protein kinase</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rock2" />
    <Graphics CenterX="626.6666666666666" CenterY="373.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="19878" />
  </DataNode>
  <DataNode TextLabel="Git2" GraphId="edf" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">GIT2; G protein-coupled receptor kinase-interactor 2</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Git2" />
    <Graphics CenterX="760.0" CenterY="136.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="26431" />
  </DataNode>
  <DataNode TextLabel="Myo" GraphId="ee2" Type="GeneProduct">
    <Graphics CenterX="900.0" CenterY="363.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="17928" />
  </DataNode>
  <DataNode TextLabel="Vasp" GraphId="ef9" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">VASP; vasodilator-stimulated phosphoprotein</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Vasp" />
    <Graphics CenterX="233.33333333333334" CenterY="130.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22323" />
  </DataNode>
  <DataNode TextLabel="p110" GraphId="f05" Type="GeneProduct" GroupRef="de408">
    <Graphics CenterX="470.0" CenterY="286.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
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  <DataNode TextLabel="Itga6" GraphId="f24" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga6" />
    <Graphics CenterX="720.0" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16403" />
  </DataNode>
  <DataNode TextLabel="Pak1" GraphId="f3c" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog  yeast) [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pak1" />
    <Graphics CenterX="293.3333333333333" CenterY="576.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18479" />
  </DataNode>
  <DataNode TextLabel="Akt1" GraphId="f4a" Type="GeneProduct" GroupRef="c03b0">
    <Comment Source="GenMAPP remarks">AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt1" />
    <Graphics CenterX="900.0" CenterY="266.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11651" />
  </DataNode>
  <DataNode TextLabel="Grb2" GraphId="f57" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">GRB2; growth factor receptor-bound protein 2</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Grb2" />
    <Graphics CenterX="240.0" CenterY="380.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14784" />
  </DataNode>
  <DataNode TextLabel="Itgb5" GraphId="f5c" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itgb5" />
    <Graphics CenterX="970.0" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16419" />
  </DataNode>
  <DataNode TextLabel="Itga8" GraphId="f6e" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga8" />
    <Graphics CenterX="796.6666666666666" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="241226" />
  </DataNode>
  <DataNode TextLabel="Itga11" GraphId="f82" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Itga11" />
    <Graphics CenterX="796.6666666666666" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="319480" />
  </DataNode>
  <DataNode TextLabel="Arhgef7" GraphId="f96" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Arhgef7" />
    <Graphics CenterX="886.6666666666666" CenterY="136.66666666666666" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="54126" />
  </DataNode>
  <DataNode TextLabel="Mylk2" GraphId="fa2" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MYLK2; myosin light chain kinase 2  skeletal muscle [EC:2.7.1.117</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mylk2" />
    <Graphics CenterX="790.0" CenterY="430.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="228785" />
  </DataNode>
  <DataNode TextLabel="Pak4" GraphId="fb9" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pak4" />
    <Graphics CenterX="293.3333333333333" CenterY="636.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="70584" />
  </DataNode>
  <DataNode TextLabel="Mapk4" GraphId="fc1" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk4" />
    <Graphics CenterX="596.6666666666666" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="225724" />
  </DataNode>
  <DataNode TextLabel="Mapk12" GraphId="fca" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk12" />
    <Graphics CenterX="596.6666666666666" CenterY="550.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="29857" />
  </DataNode>
  <DataNode TextLabel="Rac3" GraphId="fcc" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">RAC3; ras-related C3 botulinum toxin substrate 3 (rho family  small GTP binding protein Rac3)</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Rac3" />
    <Graphics CenterX="830.0" CenterY="233.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="170758" />
  </DataNode>
  <DataNode TextLabel="Tln1" GraphId="fe5" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">TLN1; talin 1</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Tln1" />
    <Graphics CenterX="210.0" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="21894" />
  </DataNode>
  <DataNode TextLabel="Shc3" GraphId="ff0" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">SHC3; neuronal Sh</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Shc3" />
    <Graphics CenterX="200.0" CenterY="360.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20418" />
  </DataNode>
  <DataNode TextLabel="Ptk2" GraphId="ff6" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ptk2" />
    <Graphics CenterX="340.0" CenterY="286.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14083" />
  </DataNode>
  <Interaction GraphId="a0082">
    <Graphics ZOrder="12288" LineThickness="1.0">
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      <Point X="200.0" Y="330.0" GraphRef="d86" RelX="0.0" RelY="-1.0" />
    </Graphics>
    <Xref Database="" ID="" />
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