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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Statin pathway" Data-Source="WikiPathways" Version="WP1_r137182" Author="[Nsalomonis, MaintBot, Khanspers, BruceConklin, TestUser, AlexanderPico, Thomas, Mkutmon, Andra, Egonw, Ddigles, Eweitz]" Last-Modified="20250228083128" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. 

Sources: [PharmGKB](https://www.pharmgkb.org/pathway/PA2031) and [Wikipedia](http://en.wikipedia.org/wiki/Statin).</Comment>
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