<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Apoptosis" Data-Source="WikiPathways" Version="WP1254_r95784" Author="[MaintBot, MartijnVanIersel, Thomas, Christine Chichester, AlexanderPico, Mkutmon]" Last-Modified="20180119143657" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.</Comment>
  <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP254_r95107 WP254 (r95107)] with a 92.0% conversion rate.</Comment>
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  <DataNode TextLabel="MIR29A" GraphId="ec258" Type="GeneProduct">
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  <DataNode TextLabel="Pmaip1" GraphId="fe0" Type="GeneProduct" GroupRef="ff56d">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5366</Comment>
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  <DataNode TextLabel="Casp9" GraphId="d80" Type="GeneProduct">
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  <DataNode TextLabel="Mdm2" GraphId="f68" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4193</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000020184" />
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  <DataNode TextLabel="Bak1" GraphId="c02" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:578</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000057789" />
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  <DataNode TextLabel="Traf3" GraphId="e37" Type="GeneProduct" GroupRef="ffcf1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7187</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRAF3 | TNF receptor-associated factor 3" />
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  <DataNode TextLabel="Irf1" GraphId="f5a" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3659</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF1 | interferon regulatory factor 1" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000018899" />
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  <DataNode TextLabel="Nfkb1" GraphId="e75" Type="GeneProduct" GroupRef="defd7">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000028163" />
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  <DataNode TextLabel="Fas" GraphId="d44" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:355</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="FAS | Fas (TNF receptor superfamily member 6)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000024778" />
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  <DataNode TextLabel="Birc2" GraphId="a68" Type="GeneProduct" GroupRef="dbe72">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:329</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BIRC2 | baculoviral IAP repeat-containing 2" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000057367" />
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  <DataNode TextLabel="Diablo" GraphId="a6b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:56616</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="DIABLO | diablo homolog (Drosophila)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000029433" />
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  <DataNode TextLabel="Akt1" GraphId="d5d" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:207</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="AKT1 | v-akt murine thymoma viral oncogene homo..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000001729" />
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  <DataNode TextLabel="Gzmc" GraphId="d0c" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3002</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GZMB | granzyme B (granzyme 2 cytotoxic T-lymp..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000079186" />
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  <DataNode TextLabel="Tnfrsf21" GraphId="a75" Type="GeneProduct" GroupRef="e0e2c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27242</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFRSF21 | tumor necrosis factor receptor super..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000023915" />
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  <DataNode TextLabel="Bad" GraphId="bd8" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:572</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BAD | BCL2-antagonist of cell death" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000024959" />
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  <DataNode TextLabel="Nfkbia" GraphId="f31" Type="GeneProduct" GroupRef="e38bb">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4792</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKBIA | nuclear factor of kappa light polypept..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021025" />
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  <DataNode TextLabel="Casp1" GraphId="cbb" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:834</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP1 | caspase 1 apoptosis-related cysteine p..." />
    <Graphics CenterX="1074.0" CenterY="216.0" Width="60.0" Height="20.0" ZOrder="32798" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025888" />
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  <DataNode TextLabel="Ripk1" GraphId="f61" Type="GeneProduct" GroupRef="f44cf">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RIPK1 | receptor (TNFRSF)-interacting serine-th..." />
    <Graphics CenterX="507.3333333333333" CenterY="153.6666666666666" Width="60.0" Height="20.0" ZOrder="32800" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021408" />
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  <DataNode TextLabel="Irf2" GraphId="af7" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3660</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF2 | interferon regulatory factor 2" />
    <Graphics CenterX="1010.0" CenterY="546.6666666666666" Width="60.0" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031627" />
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  <DataNode TextLabel="Nfkbib" GraphId="d93" Type="GeneProduct" GroupRef="e38bb">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4793</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKBIB | nuclear factor of kappa light polypept..." />
    <Graphics CenterX="236.0" CenterY="514.0" Width="60.0" Height="20.0" ZOrder="32804" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030595" />
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  <DataNode TextLabel="Lta" GraphId="b09" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4049</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="LTA | lymphotoxin alpha (TNF superfamily membe..." />
    <Graphics CenterX="110.0" CenterY="103.33333333333333" Width="60.0" Height="20.0" ZOrder="32806" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024402" />
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  <DataNode TextLabel="Casp4" GraphId="cc5" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:837</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP4 | caspase 4 apoptosis-related cysteine p..." />
    <Graphics CenterX="991.333333333333" CenterY="190.0" Width="60.0" Height="20.0" ZOrder="32808" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000033538" />
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  <DataNode TextLabel="Irf6" GraphId="ecc" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3664</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF6 | interferon regulatory factor 6" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000026638" />
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  <DataNode TextLabel="Casp3" GraphId="cd5" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:836</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP3 | caspase 3 apoptosis-related cysteine p..." />
    <Graphics CenterX="990.0" CenterY="313.3333333333333" Width="60.0" Height="20.0" ZOrder="32812" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031628" />
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  <DataNode TextLabel="Prf1" GraphId="e23" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5551</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRF1 | perforin 1 (pore forming protein)" />
    <Graphics CenterX="900.4610447928713" CenterY="154.91557735599847" Width="60.0" Height="20.0" ZOrder="32814" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000037202" />
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  <DataNode TextLabel="Tnfrsf1a" GraphId="f02" Type="GeneProduct" GroupRef="a85e8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7132</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFRSF1A | tumor necrosis factor receptor super..." />
    <Graphics CenterX="395.3333333333333" CenterY="208.0" Width="73.33333333333333" Height="20.0" ZOrder="32816" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030341" />
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  <DataNode TextLabel="Igf1r" GraphId="d2c" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3480</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGF1R | insulin-like growth factor 1 receptor" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000005533" />
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  <DataNode TextLabel="Rela" GraphId="aba" Type="GeneProduct" GroupRef="defd7">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5970</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RELA | v-rel reticuloendotheliosis viral oncoge..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000024927" />
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  <DataNode TextLabel="Chuk" GraphId="c39" Type="GeneProduct" GroupRef="cb605">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1147</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CHUK | conserved helix-loop-helix ubiquitous ki..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000025199" />
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  <DataNode TextLabel="Bax" GraphId="fac" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:581</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BAX | BCL2-associated X protein" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000003873" />
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  <DataNode TextLabel="Apaf1" GraphId="aa8" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:317</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="APAF1 | apoptotic protease activating factor" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000019979" />
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  <DataNode TextLabel="Tnfrsf1b" GraphId="ced" Type="GeneProduct" GroupRef="e0e2c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7133</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFRSF1B | tumor necrosis factor receptor super..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000028599" />
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  <DataNode TextLabel="CASP10" GraphId="eed" Type="GeneProduct">
    <Comment Source="HomologyMapper">No homologues found for original id L:843</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP10 | caspase 10 apoptosis-related cysteine..." />
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="Birc3" GraphId="ce0" Type="GeneProduct" GroupRef="dbe72">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:330</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BIRC3 | baculoviral IAP repeat-containing 3" />
    <Graphics CenterX="88.33333333333333" CenterY="303.3333333333333" Width="60.0" Height="20.0" ZOrder="32832" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032000" />
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  <DataNode TextLabel="Bid" GraphId="dde" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:637</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BID | BH3 interacting domain death agonist" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000004446" />
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  <DataNode TextLabel="Tnfrsf25" GraphId="f66" Type="GeneProduct" GroupRef="e0e2c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8718</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFRSF25 | tumor necrosis factor receptor super..." />
    <Graphics CenterX="94.28662820943006" CenterY="173.71337179056988" Width="80.00000000000001" Height="19.999999999999996" ZOrder="32836" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024793" />
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  <DataNode TextLabel="Mapk10" GraphId="d43" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10" />
    <Graphics CenterX="280.0" CenterY="425.3333333333333" Width="60.0" Height="20.0" ZOrder="32838" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000046709" />
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  <DataNode TextLabel="Traf1" GraphId="ea1" Type="GeneProduct" GroupRef="ffcf1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7185</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRAF1 | TNF receptor-associated factor 1" />
    <Graphics CenterX="192.33333333333334" CenterY="278.0" Width="60.0" Height="20.0" ZOrder="32840" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026875" />
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  <DataNode TextLabel="Ikbkb" GraphId="fd3" Type="GeneProduct" GroupRef="cb605">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3551</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IKBKB | inhibitor of kappa light polypeptide ge..." />
    <Graphics CenterX="116.99999999999994" CenterY="387.3333333333335" Width="60.0" Height="20.0" ZOrder="32842" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031537" />
  </DataNode>
  <DataNode TextLabel="Irf5" GraphId="a6a" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3663</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF5 | interferon regulatory factor 5" />
    <Graphics CenterX="1096.6666666666667" CenterY="543.3333333333334" Width="60.0" Height="20.0" ZOrder="32844" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029771" />
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  <DataNode TextLabel="Dffa" GraphId="bdb" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1676</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="DFFA | DNA fragmentation factor 45kDa alpha p..." />
    <Graphics CenterX="666.6666666666666" CenterY="738.0000000000001" Width="60.0" Height="20.0" ZOrder="32846" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000028974" />
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  <DataNode TextLabel="CYCS" GraphId="a28" Type="GeneProduct">
    <Comment Source="HomologyMapper">No homologues found for original id L:54205</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CYCS | cytochrome c somatic" />
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="Nfkbib" GraphId="aa1" Type="GeneProduct" GroupRef="defd7">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4793</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKBIB | nuclear factor of kappa light polypept..." />
    <Graphics CenterX="117.33333333333333" CenterY="480.0" Width="60.0" Height="20.0" ZOrder="32850" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030595" />
  </DataNode>
  <DataNode TextLabel="BBC3" GraphId="fa6" Type="GeneProduct" GroupRef="ff56d">
    <Comment Source="HomologyMapper">No homologues found for original id L:27113</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BBC3 | BCL2 binding component 3" />
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="Irf3" GraphId="e31" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3661</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF3 | interferon regulatory factor 3" />
    <Graphics CenterX="1010.0" CenterY="566.6666666666666" Width="60.0" Height="20.0" ZOrder="32854" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000003184" />
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  <DataNode TextLabel="Casp2" GraphId="c90" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:835</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP2 | caspase 2 apoptosis-related cysteine p..." />
    <Graphics CenterX="990.0" CenterY="360.0" Width="60.0" Height="20.0" ZOrder="32856" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029863" />
  </DataNode>
  <DataNode TextLabel="Hrk" GraphId="c3d" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8739</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HRK | harakiri BCL2 interacting protein (conta..." />
    <Graphics CenterX="630.0000000000005" CenterY="339.33333333333326" Width="60.0" Height="20.0" ZOrder="32858" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000046607" />
  </DataNode>
  <DataNode TextLabel="Trp73" GraphId="eba" Type="GeneProduct" GroupRef="b80c8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7161</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TP73 | tumor protein p73" />
    <Graphics CenterX="860.0" CenterY="540.0" Width="60.0" Height="20.0" ZOrder="32860" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029026" />
  </DataNode>
  <DataNode TextLabel="Scaf11" GraphId="f2e" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9169</Comment>
    <Graphics CenterX="933.3333333333334" CenterY="215.33333333333331" Width="60.0" Height="20.0" ZOrder="32862" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000033228" />
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  <DataNode TextLabel="Casp7" GraphId="ba6" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:840</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP7 | caspase 7 apoptosis-related cysteine p..." />
    <Graphics CenterX="990.0" CenterY="336.6666666666667" Width="60.0" Height="20.0" ZOrder="32864" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025076" />
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  <DataNode TextLabel="Myc" GraphId="a21" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4609</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYC | v-myc myelocytomatosis viral oncogene hom..." />
    <Graphics CenterX="460.6666666666669" CenterY="684.6666666666669" Width="60.0" Height="20.0" ZOrder="32866" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022346" />
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  <DataNode TextLabel="Tnf" GraphId="ac5" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7124</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNF | tumor necrosis factor (TNF superfamily m..." />
    <Graphics CenterX="286.6666666666667" CenterY="103.33333333333333" Width="60.0" Height="20.0" ZOrder="32868" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024401" />
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  <DataNode TextLabel="Igf2" GraphId="d3e" Type="GeneProduct" GroupRef="d7a6b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3481</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGF2 | insulin-like growth factor 2 (somatomedi..." />
    <Graphics CenterX="1250.8973727595687" CenterY="166.66666666666666" Width="40.0" Height="20.0" ZOrder="32870" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000048583" />
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  <DataNode TextLabel="Cradd" GraphId="bd4" Type="GeneProduct" GroupRef="a85e8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8738</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CRADD | CASP2 and RIPK1 domain containing adapt..." />
    <Graphics CenterX="395.3333333333333" CenterY="228.0" Width="73.33333333333333" Height="20.0" ZOrder="32872" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000045867" />
  </DataNode>
  <DataNode TextLabel="Ikbkg" GraphId="e69" Type="GeneProduct" GroupRef="cb605">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8517</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IKBKG | inhibitor of kappa light polypeptide ge..." />
    <Graphics CenterX="116.99999999999994" CenterY="407.3333333333335" Width="60.0" Height="20.0" ZOrder="32874" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000004221" />
  </DataNode>
  <DataNode TextLabel="Bok" GraphId="ca7" Type="GeneProduct" GroupRef="ff56d">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:666</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BOK | BCL2-related ovarian killer" />
    <Graphics CenterX="594.0000000000007" CenterY="624.6666666666662" Width="53.333333333333336" Height="20.0" ZOrder="32876" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026278" />
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  <DataNode TextLabel="Traf2" GraphId="def" Type="GeneProduct" GroupRef="ffcf1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7186</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRAF2 | TNF receptor-associated factor 2" />
    <Graphics CenterX="192.33333333333334" CenterY="298.6666666666667" Width="60.0" Height="21.333333333333332" ZOrder="32878" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026942" />
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  <DataNode TextLabel="Cflar" GraphId="ecf" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8837</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CFLAR | CASP8 and FADD-like apoptosis regulator..." />
    <Graphics CenterX="506.6666666666663" CenterY="102.6666666666667" Width="53.333333333333336" Height="20.0" ZOrder="32880" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026031" />
  </DataNode>
  <DataNode TextLabel="Bcl2l2" GraphId="f1a" Type="GeneProduct" GroupRef="c2232">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:599</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BCL2L2 | BCL2-like 2" />
    <Graphics CenterX="395.33333333333337" CenterY="342.3333333333333" Width="60.0" Height="20.0" ZOrder="32882" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000089682" />
  </DataNode>
  <DataNode TextLabel="Pik3r1" GraphId="f13" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5295</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3R1 | phosphoinositide-3-kinase regulatory ..." />
    <Graphics CenterX="1250.8973727595687" CenterY="276.0" Width="53.333333333333336" Height="20.0" ZOrder="32884" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000041417" />
  </DataNode>
  <DataNode TextLabel="Tradd" GraphId="e0c" Type="GeneProduct" GroupRef="e0e2c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8717</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRADD | TNFRSF1A-associated via death domain" />
    <Graphics CenterX="94.28662820943009" CenterY="213.71337179056988" Width="80.00000000000001" Height="19.999999999999996" ZOrder="32886" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031887" />
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  <DataNode TextLabel="Birc5" GraphId="cc6" Type="GeneProduct" GroupRef="a904c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:332</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BIRC5 | baculoviral IAP repeat-containing 5 (su..." />
    <Graphics CenterX="880.6666666666669" CenterY="425.33333333333326" Width="60.0" Height="20.0" ZOrder="32888" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000017716" />
  </DataNode>
  <DataNode TextLabel="Igf1" GraphId="fd7" Type="GeneProduct" GroupRef="d7a6b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3479</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGF1 | insulin-like growth factor 1 (somatomedi..." />
    <Graphics CenterX="1250.8973727595687" CenterY="146.66666666666666" Width="40.0" Height="20.0" ZOrder="32890" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020053" />
  </DataNode>
  <DataNode TextLabel="Tnfrsf10b" GraphId="c17" Type="GeneProduct" GroupRef="e0e2c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8795</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFRSF10B | tumor necrosis factor receptor supe..." />
    <Graphics CenterX="194.2866282094301" CenterY="176.38003845723654" Width="80.0" Height="20.0" ZOrder="32892" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022074" />
  </DataNode>
  <DataNode TextLabel="Jun" GraphId="a9e" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="JUN | v-jun sarcoma virus 17 oncogene homolog (..." />
    <Graphics CenterX="370.0" CenterY="710.0" Width="60.0" Height="20.0" ZOrder="32894" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000052684" />
  </DataNode>
  <DataNode TextLabel="Bnip3l" GraphId="a93" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:665</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BNIP3L | BCL2/adenovirus E1B 19kDa interacting ..." />
    <Graphics CenterX="556.6666666666667" CenterY="318.00000000000006" Width="60.0" Height="20.0" ZOrder="32896" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022051" />
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  <DataNode TextLabel="Dffb" GraphId="a5f" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1677</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="DFFB | DNA fragmentation factor 40kDa beta po..." />
    <Graphics CenterX="667.3333333333334" CenterY="685.3333333333334" Width="60.0" Height="20.0" ZOrder="32898" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029027" />
  </DataNode>
  <DataNode TextLabel="Tradd" GraphId="d39" Type="GeneProduct" GroupRef="f44cf">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8717</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRADD | TNFRSF1A-associated via death domain" />
    <Graphics CenterX="507.3333333333333" CenterY="193.6666666666666" Width="60.0" Height="20.0" ZOrder="32900" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031887" />
  </DataNode>
  <DataNode TextLabel="Bcl2" GraphId="d79" Type="GeneProduct" GroupRef="c2232">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:596</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BCL2 | B-cell CLL/lymphoma 2" />
    <Graphics CenterX="395.33333333333337" CenterY="382.3333333333333" Width="60.0" Height="20.0" ZOrder="32902" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000057329" />
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  <DataNode TextLabel="Tnfrsf1a" GraphId="c09" Type="GeneProduct" GroupRef="e0e2c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7132</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFRSF1A | tumor necrosis factor receptor super..." />
    <Graphics CenterX="94.28662820943006" CenterY="193.71337179056988" Width="80.00000000000001" Height="19.999999999999996" ZOrder="32904" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030341" />
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  <DataNode TextLabel="Irf7" GraphId="e68" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3665</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF7 | interferon regulatory factor 7" />
    <Graphics CenterX="1190.0" CenterY="543.3333333333334" Width="60.0" Height="20.0" ZOrder="32906" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025498" />
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  <DataNode TextLabel="Rela" GraphId="c1a" Type="GeneProduct" GroupRef="c5ac6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5970</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RELA | v-rel reticuloendotheliosis viral oncoge..." />
    <Graphics CenterX="117.33333333333334" CenterY="712.0000000000008" Width="60.0" Height="20.0" ZOrder="32908" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024927" />
  </DataNode>
  <DataNode TextLabel="Bcl2l1" GraphId="fed" Type="GeneProduct" GroupRef="c2232">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:598</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BCL2L1 | BCL2-like 1" />
    <Graphics CenterX="395.33333333333337" CenterY="362.3333333333333" Width="60.0" Height="20.0" ZOrder="32910" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000007659" />
  </DataNode>
  <DataNode TextLabel="Irf4" GraphId="a02" Type="GeneProduct" GroupRef="c537f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3662</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF4 | interferon regulatory factor 4" />
    <Graphics CenterX="1096.6666666666667" CenterY="523.3333333333334" Width="60.0" Height="20.0" ZOrder="32912" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021356" />
  </DataNode>
  <DataNode TextLabel="Nfkbie" GraphId="dd3" Type="GeneProduct" GroupRef="defd7">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4794</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKBIE | nuclear factor of kappa light polypept..." />
    <Graphics CenterX="117.33333333333333" CenterY="500.0" Width="60.0" Height="20.0" ZOrder="32914" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000023947" />
  </DataNode>
  <DataNode TextLabel="Trp53" GraphId="cbf" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7157</Comment>
    <BiopaxRef>c76</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TP53 | tumor protein p53 (Li-Fraumeni syndrome)..." />
    <Graphics CenterX="439.9999999999999" CenterY="604.3333333333333" Width="60.0" Height="20.0" ZOrder="32916" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000059552" />
  </DataNode>
  <DataNode TextLabel="Map2k4" GraphId="e16" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K4 | mitogen-activated protein kinase kinas..." />
    <Graphics CenterX="280.6666666666667" CenterY="369.3333333333333" Width="60.0" Height="20.0" ZOrder="32918" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000033352" />
  </DataNode>
  <DataNode TextLabel="Ripk1" GraphId="d64" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RIPK1 | receptor (TNFRSF)-interacting serine-th..." />
    <Graphics CenterX="42.30333164757474" CenterY="414.9499971904022" Width="60.0" Height="20.0" ZOrder="32920" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021408" />
  </DataNode>
  <DataNode TextLabel="CDKN2A" GraphId="b98" Type="GeneProduct">
    <Comment Source="HomologyMapper">No homologues found for original id L:1029</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN2A | cyclin-dependent kinase inhibitor 2A (..." />
    <Graphics CenterX="384.66666666666674" CenterY="656.6666666666666" Width="60.0" Height="20.0" ZOrder="32922" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
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  <DataNode TextLabel="Casp8" GraphId="a45" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:841</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP8 | caspase 8 apoptosis-related cysteine p..." />
    <Graphics CenterX="780.0" CenterY="280.0" Width="60.0" Height="20.0" ZOrder="32924" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026029" />
  </DataNode>
  <DataNode TextLabel="Xiap" GraphId="dc5" Type="GeneProduct" GroupRef="a904c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:331</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BIRC4 | baculoviral IAP repeat-containing 4" />
    <Graphics CenterX="880.6666666666669" CenterY="405.33333333333326" Width="60.0" Height="20.0" ZOrder="32926" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025860" />
  </DataNode>
  <DataNode TextLabel="Bad" GraphId="d71" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:572</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="BAD | BCL2-antagonist of cell death" />
    <Graphics CenterX="474.00000000000006" CenterY="324.6666666666667" Width="60.0" Height="20.0" ZOrder="32928" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024959" />
  </DataNode>
  <DataNode TextLabel="Nfkbia" GraphId="d21" Type="GeneProduct" GroupRef="defd7">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4792</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKBIA | nuclear factor of kappa light polypept..." />
    <Graphics CenterX="117.33333333333333" CenterY="520.0" Width="60.0" Height="20.0" ZOrder="32930" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021025" />
  </DataNode>
  <DataNode TextLabel="Fasl" GraphId="ff0" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:356</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="FASLG | Fas ligand (TNF superfamily member 6)" />
    <Graphics CenterX="720.0" CenterY="66.66666666666667" Width="60.0" Height="20.0" ZOrder="32932" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000000817" />
  </DataNode>
  <DataNode TextLabel="Tnfsf10" GraphId="a9b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8743</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNFSF10 | tumor necrosis factor (ligand) superf..." />
    <Graphics CenterX="195.33333333333337" CenterY="103.33333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32934" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000039304" />
  </DataNode>
  <DataNode TextLabel="Nfkbie" GraphId="db3" Type="GeneProduct" GroupRef="e38bb">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4794</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKBIE | nuclear factor of kappa light polypept..." />
    <Graphics CenterX="236.0" CenterY="534.0" Width="60.0" Height="20.0" ZOrder="32936" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000023947" />
  </DataNode>
  <DataNode TextLabel="Hells" GraphId="d45" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3070</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HELLS | helicase lymphoid-specific" />
    <Graphics CenterX="283.3333333333333" CenterY="650.6666666666666" Width="60.0" Height="20.0" ZOrder="32938" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025001" />
  </DataNode>
  <DataNode TextLabel="Nfkb1" GraphId="b67" Type="GeneProduct" GroupRef="c5ac6">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKB1 | nuclear factor of kappa light polypepti..." />
    <Graphics CenterX="117.33333333333334" CenterY="692.0000000000008" Width="60.0" Height="20.0" ZOrder="32940" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000028163" />
  </DataNode>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nam JW</bp:AUTHORS>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mir-29 regulates Mcl-1 protein expression and apoptosis.</bp:TITLE>
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