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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="G1 to S cell cycle control" Data-Source="WikiPathways" Version="WP413_r84705" Author="[A.C.Zambon, Nsalomonis, MaintBot, Khanspers, Christine Chichester, Mkutmon]" Last-Modified="20160315220618" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects.

Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;FOCUS_SPECIES=Homo%20sapiens&amp;ID=69615&amp;</Comment>
  <Comment Source="GenMAPP notes">Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.</Comment>
  <BiopaxRef>e5642</BiopaxRef>
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