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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Exercise-induced circadian regulation" Data-Source="WikiPathways" Version="WP544_r117882" Author="[A.C.Zambon, MaintBot, Evelo, Khanspers, Mkutmon, AlexanderPico, Susan, Eweitz]" Last-Modified="20210523102125" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Time- and exercise-dependent gene regulation in human skeletal muscle, http://genomebiology.com/2003/4/10/R61

Mouse genes regulated in the diurnal (inferred from human) and compared with mouse genes that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P &lt; 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change &gt; 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.</Comment>
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    <Comment Source="GenMAPP remarks">93833 s at</Comment>
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    <Comment Source="GenMAPP remarks">104516 at</Comment>
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    <Comment Source="GenMAPP remarks">99076 at</Comment>
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    <Comment Source="GenMAPP remarks">97531 at</Comment>
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    <Comment Source="GenMAPP remarks">100535 at</Comment>
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    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Clock | circadian locomoter output cycles kaput..." />
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    <Comment Source="GenMAPP remarks">102265 at</Comment>
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    <Comment Source="GenMAPP remarks">95508 at</Comment>
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    <Comment Source="GenMAPP remarks">97261 at</Comment>
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    <Comment Source="GenMAPP remarks">97843 at</Comment>
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    <Comment Source="GenMAPP remarks">93933 at</Comment>
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    <Comment Source="GenMAPP remarks">93866 s at</Comment>
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    <Comment Source="GenMAPP remarks">94481 at</Comment>
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    <Comment Source="GenMAPP remarks">93829 at</Comment>
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    <Comment Source="GenMAPP remarks">94835 f at</Comment>
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    <Comment Source="GenMAPP remarks">99583 at</Comment>
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    <Comment Source="GenMAPP remarks">95096 at</Comment>
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    <Comment Source="GenMAPP remarks">96564 at</Comment>
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    <Comment Source="GenMAPP remarks">160309 at</Comment>
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    <Comment Source="GenMAPP remarks">97459 at</Comment>
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    <Comment Source="GenMAPP remarks">93872 at</Comment>
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    <Comment Source="GenMAPP remarks">162346 f at</Comment>
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    <Comment Source="GenMAPP remarks">93527 at</Comment>
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    <Comment Source="GenMAPP remarks">93104 at</Comment>
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    <Comment Source="GenMAPP remarks">103888 at</Comment>
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