<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Mechanisms associated with pluripotency" Data-Source="WikiPathways" Version="WP1763_r126404" Author="[C.Harder, AlexanderPico, MaintBot, Ddigles, Mkutmon, Evelo, Eweitz, Egonw]" Last-Modified="20230426192938" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">The aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we intentionally focused on information flow, neglecting reactions, metabolites, intracellular movement of components, and their modifications such as protein phosphorylation Each edge can be seen as direct mechanism between its nodes. For more information, see
Som A, Harder C, Greber B, Siatkowski M, Paudel Y, et al. 2010 The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications. PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015165

The June 2010 PluriNetWork described in the paper can be found at http://www.ibima.med.uni-rostock.de/IBIMA/PluriNetWork/ . The PluriNetWork at WikiPathWays started with the December 2010 version.</Comment>
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  <DataNode TextLabel="Smarcad1" GraphId="n0" Type="GeneProduct">
    <Comment>full name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1</Comment>
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    <Xref Database="Entrez Gene" ID="13990"/>
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  <DataNode TextLabel="Crebbp" GraphId="n1" Type="GeneProduct">
    <Comment>full name: CREB binding protein</Comment>
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    <Xref Database="Entrez Gene" ID="12914" />
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  <DataNode TextLabel="Rel" GraphId="n10" Type="GeneProduct">
    <Comment>full name: reticuloendotheliosis oncogene</Comment>
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    <Xref Database="Entrez Gene" ID="19696" />
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  <DataNode TextLabel="Ctbp1" GraphId="n100" Type="GeneProduct">
    <Comment>full name: C-terminal binding protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="13016" />
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  <DataNode TextLabel="Tert" GraphId="n101" Type="GeneProduct">
    <Comment>full name: telomerase reverse transcriptase</Comment>
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    <Xref Database="Entrez Gene" ID="21752" />
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  <DataNode TextLabel="Cdkn2a" GraphId="n102" Type="GeneProduct">
    <Comment>full name: cyclin-dependent kinase inhibitor 2A</Comment>
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    <Xref Database="Entrez Gene" ID="12578" />
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  <DataNode TextLabel="Mdm2" GraphId="n103" Type="GeneProduct">
    <Comment>full name: transformed mouse 3T3 cell double minute 2</Comment>
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    <Xref Database="Entrez Gene" ID="17246" />
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  <DataNode TextLabel="Cdkn1a" GraphId="n104" Type="GeneProduct">
    <Comment>full name: cyclin-dependent kinase inhibitor 1A (P21)</Comment>
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    <Xref Database="Entrez Gene" ID="12575" />
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  <DataNode TextLabel="Zfp143" GraphId="n105" Type="GeneProduct">
    <Comment>full name: zinc finger protein 143</Comment>
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    <Xref Database="Entrez Gene" ID="20841" />
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  <DataNode TextLabel="Nr2f2" GraphId="n106" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 2, group F, member 2</Comment>
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    <Xref Database="Entrez Gene" ID="11819" />
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  <DataNode TextLabel="Nr2f1" GraphId="n107" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 2, group F, member 1</Comment>
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    <Xref Database="Entrez Gene" ID="13865" />
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  <DataNode TextLabel="Sp1" GraphId="n108" Type="GeneProduct">
    <Comment>full name: trans-acting transcription factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="20683" />
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  <DataNode TextLabel="Xist" GraphId="n109" Type="GeneProduct">
    <Comment>full name: inactive X specific transcripts</Comment>
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    <Xref Database="Entrez Gene" ID="213742" />
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  <DataNode TextLabel="Mpl" GraphId="n11" Type="GeneProduct">
    <Comment>full name: myeloproliferative leukemia virus oncogene</Comment>
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    <Xref Database="Entrez Gene" ID="17480" />
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  <DataNode TextLabel="Fgf4" GraphId="n110" Type="GeneProduct">
    <Comment>full name: fibroblast growth factor 4</Comment>
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    <Xref Database="Entrez Gene" ID="14175" />
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  <DataNode TextLabel="Tcfcp2l1" GraphId="n111" Type="GeneProduct">
    <Comment>full name: transcription factor CP2-like 1</Comment>
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    <Xref Database="Entrez Gene" ID="81879" />
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  <DataNode TextLabel="Mycn" GraphId="n112" Type="GeneProduct">
    <Comment>full name: v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)</Comment>
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  <DataNode TextLabel="Bmpr2" GraphId="n113" Type="GeneProduct">
    <Comment>full name: bone morphogenic protein receptor, type II (serine/threonine kinase)</Comment>
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    <Xref Database="Entrez Gene" ID="12168" />
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  <DataNode TextLabel="Smad4" GraphId="n114" Type="GeneProduct">
    <Comment>full name: MAD homolog 4 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="17128" />
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  <DataNode TextLabel="Notch1" GraphId="n115" Type="GeneProduct">
    <Comment>full name: Notch gene homolog 1 (Drosophila)</Comment>
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  <DataNode TextLabel="Rras" GraphId="n116" Type="GeneProduct">
    <Comment>full name: Harvey rat sarcoma oncogene, subgroup R</Comment>
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  <DataNode TextLabel="Wnt5a" GraphId="n117" Type="GeneProduct">
    <Comment>full name: wingless-related MMTV integration site 5A</Comment>
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    <Xref Database="Entrez Gene" ID="22418" />
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  <DataNode TextLabel="Pias2" GraphId="n118" Type="GeneProduct">
    <Comment>full name: protein inhibitor of activated STAT 2</Comment>
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    <Xref Database="Entrez Gene" ID="17344" />
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  <DataNode TextLabel="Psen1" GraphId="n119" Type="GeneProduct">
    <Comment>full name: Presenilin 1</Comment>
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    <Xref Database="Entrez Gene" ID="19164" />
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  <DataNode TextLabel="Tpo" GraphId="n12" Type="GeneProduct">
    <Comment>full name: thyroid peroxidase</Comment>
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    <Xref Database="Entrez Gene" ID="22018" />
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  <DataNode TextLabel="Dkk1" GraphId="n120" Type="GeneProduct">
    <Comment>full name: dickkopf homolog 1 (Xenopus laevis)</Comment>
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    <Xref Database="Entrez Gene" ID="13380" />
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  <DataNode TextLabel="Cer1" GraphId="n121" Type="GeneProduct">
    <Comment>full name: cerberus 1 homolog (Xenopus laevis)</Comment>
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    <Xref Database="Entrez Gene" ID="12622" />
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  <DataNode TextLabel="Nfkb1" GraphId="n122" Type="GeneProduct">
    <Comment>full name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105</Comment>
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    <Xref Database="Entrez Gene" ID="18033" />
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  <DataNode TextLabel="Lefty1" GraphId="n123" Type="GeneProduct">
    <Comment>full name: left right determination factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="13590" />
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  <DataNode TextLabel="Ptprs" GraphId="n124" Type="GeneProduct">
    <Comment>full name: protein tyrosine phosphatase, receptor type, S</Comment>
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    <Xref Database="Entrez Gene" ID="19280" />
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  <DataNode TextLabel="Fbxo15" GraphId="n125" Type="GeneProduct">
    <Comment>full name: F-box protein 15</Comment>
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    <Xref Database="Entrez Gene" ID="50764" />
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  <DataNode TextLabel="Cdk2ap1" GraphId="n126" Type="GeneProduct">
    <Comment>full name: CDK2 (cyclin-dependent kinase 2)-associated protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="13445" />
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  <DataNode TextLabel="Mbd2" GraphId="n127" Type="GeneProduct">
    <Comment>full name: methyl-CpG binding domain protein 2</Comment>
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    <Xref Database="Entrez Gene" ID="17191" />
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  <DataNode TextLabel="Mbd3" GraphId="n128" Type="GeneProduct">
    <Comment>full name: methyl-CpG binding domain protein 3</Comment>
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    <Xref Database="Entrez Gene" ID="17192" />
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  <DataNode TextLabel="Ep400" GraphId="n129" Type="GeneProduct">
    <Comment>full name: E1A binding protein p400</Comment>
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    <Xref Database="Entrez Gene" ID="75560" />
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  <DataNode TextLabel="Ogt" GraphId="n13" Type="GeneProduct">
    <Comment>full name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)</Comment>
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  <DataNode TextLabel="Ube2i" GraphId="n130" Type="GeneProduct">
    <Comment>full name: ubiquitin-conjugating enzyme E2I</Comment>
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    <Xref Database="Entrez Gene" ID="22196" />
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  <DataNode TextLabel="Med12" GraphId="n131" Type="GeneProduct">
    <Comment>full name: mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)</Comment>
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  <DataNode TextLabel="Hdac2" GraphId="n132" Type="GeneProduct">
    <Comment>full name: Histone deacetylase 2</Comment>
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  <DataNode TextLabel="Trim28" GraphId="n133" Type="GeneProduct">
    <Comment>full name: Tripartitemotif-containing28</Comment>
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  <DataNode TextLabel="Yy1" GraphId="n134" Type="GeneProduct">
    <Comment>full name: YY1 transcription factor</Comment>
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  <DataNode TextLabel="Arid3b" GraphId="n135" Type="GeneProduct">
    <Comment>full name: AT rich interactive domain 3B (BRIGHT-like)</Comment>
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  <DataNode TextLabel="Rnf2" GraphId="n136" Type="GeneProduct">
    <Comment>full name: ring finger protein 2</Comment>
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    <Xref Database="Entrez Gene" ID="19821" />
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  <DataNode TextLabel="Nr5a2" GraphId="n137" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 5, group A, member 2</Comment>
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  <DataNode TextLabel="Tcf7" GraphId="n138" Type="GeneProduct">
    <Comment>full name: Transcription factor7 ,T-cell specific</Comment>
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  <DataNode TextLabel="Rcor2" GraphId="n139" Type="GeneProduct">
    <Comment>full name: REST corepressor 2</Comment>
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  <DataNode TextLabel="Cubn" GraphId="n14" Type="GeneProduct">
    <Comment>full name: cubilin (intrinsic factor-cobalamin receptor)</Comment>
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  <DataNode TextLabel="Ercc5" GraphId="n140" Type="GeneProduct">
    <Comment>full name: excision repair cross-complementing rodent repair deficiency, complementation group 5</Comment>
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  <DataNode TextLabel="Gadd45a" GraphId="n141" Type="GeneProduct">
    <Comment>full name: growth arrest and DNA-damage-inducible 45 alpha</Comment>
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    <Xref Database="Entrez Gene" ID="13197" />
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  <DataNode TextLabel="Nr6a1" GraphId="n142" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 6, group A, member 1</Comment>
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    <Xref Database="Entrez Gene" ID="328572" />
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  <DataNode TextLabel="Rif1" GraphId="n143" Type="GeneProduct">
    <Comment>full name: Rap1 interacting factor 1 homolog (yeast)</Comment>
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    <Xref Database="Entrez Gene" ID="51869" />
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  <DataNode TextLabel="Zfp281" GraphId="n144" Type="GeneProduct">
    <Comment>full name: zinc finger protein 281</Comment>
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  <DataNode TextLabel="Nacc1" GraphId="n145" Type="GeneProduct">
    <Comment>full name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing</Comment>
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  <DataNode TextLabel="Nr0b1" GraphId="n146" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 0, group B, member 1</Comment>
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    <Xref Database="Entrez Gene" ID="11614" />
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  <DataNode TextLabel="Zfx" GraphId="n147" Type="GeneProduct">
    <Comment>full name: zinc finger protein X-linked</Comment>
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    <Xref Database="Entrez Gene" ID="22764" />
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  <DataNode TextLabel="Mybl2" GraphId="n148" Type="GeneProduct">
    <Comment>full name: myeloblastosis oncogene-like 2</Comment>
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    <Xref Database="Entrez Gene" ID="17865" />
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  <DataNode TextLabel="Klf4" GraphId="n149" Type="GeneProduct">
    <Comment>full name: Kruppel-like factor 4 (gut)</Comment>
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    <Xref Database="Entrez Gene" ID="16600" />
  </DataNode>
  <DataNode TextLabel="Dhx9" GraphId="n15" Type="GeneProduct">
    <Comment>full name: DEAH (Asp-Glu-Ala-His) box polypeptide 9</Comment>
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    <Xref Database="Entrez Gene" ID="13211" />
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  <DataNode TextLabel="Rest" GraphId="n150" Type="GeneProduct">
    <Comment>full name: RE1-silencing transcription factor</Comment>
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    <Xref Database="Entrez Gene" ID="19712" />
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  <DataNode TextLabel="Thap11" GraphId="n151" Type="GeneProduct">
    <Comment>full name: THAP domain containing 11</Comment>
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    <Xref Database="Entrez Gene" ID="59016" />
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  <DataNode TextLabel="Hcfc1" GraphId="n152" Type="GeneProduct">
    <Comment>full name: host cell factor C1</Comment>
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    <Xref Database="Entrez Gene" ID="15161" />
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  <DataNode TextLabel="Pou5f1" GraphId="n153" Type="GeneProduct">
    <Comment>full name: POU domain, class 5, transcription factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="18999" />
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  <DataNode TextLabel="Mapk3" GraphId="n154" Type="GeneProduct">
    <Comment>full name: mitogen-activated protein kinase 3</Comment>
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    <Xref Database="Entrez Gene" ID="26417" />
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  <DataNode TextLabel="Tcl1" GraphId="n155" Type="GeneProduct">
    <Comment>full name: T-cell lymphoma breakpoint 1</Comment>
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  <DataNode TextLabel="Tbx3" GraphId="n156" Type="GeneProduct">
    <Comment>full name: T-box3</Comment>
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    <Xref Database="Entrez Gene" ID="21386" />
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  <DataNode TextLabel="Id1" GraphId="n157" Type="GeneProduct">
    <Comment>full name: inhibitor of DNA binding 1</Comment>
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    <Xref Database="Entrez Gene" ID="15901" />
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  <DataNode TextLabel="Gata6" GraphId="n158" Type="GeneProduct">
    <Comment>full name: GATA binding protein 6</Comment>
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    <Xref Database="Entrez Gene" ID="14465" />
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  <DataNode TextLabel="Pou2f1" GraphId="n159" Type="GeneProduct">
    <Comment>full name: POU domain, class 2, transcription factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="18986" />
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  <DataNode TextLabel="P4ha1" GraphId="n16" Type="GeneProduct">
    <Comment>full name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide</Comment>
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    <Xref Database="Entrez Gene" ID="18451" />
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  <DataNode TextLabel="Gab1" GraphId="n160" Type="GeneProduct">
    <Comment>full name: growth factor receptor bound protein 2-associated protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="14388" />
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  <DataNode TextLabel="Jak1" GraphId="n161" Type="GeneProduct">
    <Comment>full name: Janus kinase 1</Comment>
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    <Xref Database="Entrez Gene" ID="16451" />
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  <DataNode TextLabel="Socs1" GraphId="n162" Type="GeneProduct">
    <Comment>full name: suppressorofcytokinesignaling2</Comment>
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    <Xref Database="Entrez Gene" ID="216233" />
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  <DataNode TextLabel="Il6st" GraphId="n163" Type="GeneProduct">
    <Comment>full name: interleukin 6 signal transducer</Comment>
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    <Xref Database="Entrez Gene" ID="16195" />
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  <DataNode TextLabel="Lifr" GraphId="n164" Type="GeneProduct">
    <Comment>full name: leukemia inhibitory factor receptor</Comment>
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    <Xref Database="Entrez Gene" ID="16880" />
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  <DataNode TextLabel="Lif" GraphId="n165" Type="GeneProduct">
    <Comment>full name: leukemia inhibitory factor</Comment>
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    <Xref Database="Entrez Gene" ID="16878" />
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  <DataNode TextLabel="Apc" GraphId="n166" Type="GeneProduct">
    <Comment>full name: adenomatosis polyposis coli</Comment>
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    <Xref Database="Entrez Gene" ID="11789" />
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  <DataNode TextLabel="Axin1" GraphId="n167" Type="GeneProduct">
    <Comment>full name: Axin1</Comment>
    <Graphics CenterX="3867.279296875" CenterY="1570.1197509765625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="12005" />
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  <DataNode TextLabel="Lef1" GraphId="n168" Type="GeneProduct">
    <Comment>full name: lymphoid enhancer binding factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="16842" />
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  <DataNode TextLabel="Zic3" GraphId="n169" Type="GeneProduct">
    <Comment>full name: zinc finger protein of the cerebellum 3</Comment>
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    <Xref Database="Entrez Gene" ID="22773" />
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  <DataNode TextLabel="Trim33" GraphId="n17" Type="GeneProduct">
    <Comment>full name: tripartite motif-containing 33</Comment>
    <Graphics CenterX="3852.529296875" CenterY="4093.3817138671875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="94093" />
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  <DataNode TextLabel="Frap1" GraphId="n170" Type="GeneProduct">
    <Comment>full name: FK506 binding protein 12-rapamycin associated protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="56717" />
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  <DataNode TextLabel="Akt1" GraphId="n171" Type="GeneProduct">
    <Comment>full name: thymoma viral proto-oncogene 1</Comment>
    <Graphics CenterX="6113.2431640625" CenterY="1929.3756103515625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="11651" />
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  <DataNode TextLabel="Myc" GraphId="n172" Type="GeneProduct">
    <Comment>full name: myelocytomatosis oncogene</Comment>
    <Graphics CenterX="7469.346435546875" CenterY="2391.4683837890625" Width="100.0" Height="100.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="17869" />
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  <DataNode TextLabel="Cdx2" GraphId="n173" Type="GeneProduct">
    <Comment>full name: caudal type homeo box 2</Comment>
    <Graphics CenterX="4783.10107421875" CenterY="5703.00048828125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="12591" />
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  <DataNode TextLabel="Ccnd1" GraphId="n174" Type="GeneProduct">
    <Comment>full name: cyclin D1</Comment>
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    <Xref Database="Entrez Gene" ID="12443" />
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  <DataNode TextLabel="Stat3" GraphId="n175" Type="GeneProduct">
    <Comment>full name: signal transducer and activator of transcription 3</Comment>
    <Graphics CenterX="7837.550689697266" CenterY="2105.3143920898438" Width="100.0" Height="100.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="20848" />
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  <DataNode TextLabel="Sall4" GraphId="n176" Type="GeneProduct">
    <Comment>full name: sal-like 4 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="99377" />
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  <DataNode TextLabel="Foxd3" GraphId="n177" Type="GeneProduct">
    <Comment>full name: forkhead box D3</Comment>
    <Graphics CenterX="6949.384521484375" CenterY="4541.171630859375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="15221" />
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  <DataNode TextLabel="Nanog" GraphId="n178" Type="GeneProduct">
    <Comment>full name: Nanog homeobox</Comment>
    <Graphics CenterX="5257.363037109375" CenterY="4426.7322998046875" Width="500.0" Height="500.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="71950" />
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  <DataNode TextLabel="Sox2" GraphId="n179" Type="GeneProduct">
    <Comment>full name: SRY-box containing gene 2</Comment>
    <Graphics CenterX="3922.732421875" CenterY="3163.0865173339844" Width="500.0" Height="500.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="20674" />
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  <DataNode TextLabel="Ddb1" GraphId="n18" Type="GeneProduct">
    <Comment>full name: damage specific DNA binding protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="13194" />
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  <DataNode TextLabel="Trp53" GraphId="n180" Type="GeneProduct">
    <Comment>full name: transformation related protein 53</Comment>
    <Graphics CenterX="4898.978515625" CenterY="1950.89794921875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="22059" />
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  <DataNode TextLabel="Eras" GraphId="n181" Type="GeneProduct">
    <Comment>full name: ES cell-expressed Ras</Comment>
    <Graphics CenterX="6244.142822265625" CenterY="1663.46630859375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="353283" />
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  <DataNode TextLabel="Pten" GraphId="n182" Type="GeneProduct">
    <Comment>full name: phosphatase and tensin homolog</Comment>
    <Graphics CenterX="5706.57568359375" CenterY="1708.01611328125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="19211" />
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  <DataNode TextLabel="Pik3cd" GraphId="n183" Type="GeneProduct">
    <Comment>full name: phosphatidylinositol 3-kinase, catalytic delta polypeptide</Comment>
    <Graphics CenterX="6110.9697265625" CenterY="1762.251220703125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="18707" />
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  <DataNode TextLabel="Map2k1" GraphId="n184" Type="GeneProduct">
    <Comment>full name: mitogen-activated protein kinase kinase 1</Comment>
    <Graphics CenterX="7529.184844970703" CenterY="1725.9578857421875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="26395" />
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  <DataNode TextLabel="Raf1" GraphId="n185" Type="GeneProduct">
    <Comment>full name: v-raf-leukemia viral oncogene 1</Comment>
    <Graphics CenterX="7212.516784667969" CenterY="1481.5052490234375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="110157" />
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  <DataNode TextLabel="Hras1" GraphId="n186" Type="GeneProduct">
    <Comment>full name: Harvey rat sarcoma virus oncogene 1</Comment>
    <Graphics CenterX="7211.268981933594" CenterY="1323.354248046875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="15461" />
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  <DataNode TextLabel="Smad2" GraphId="n187" Type="GeneProduct">
    <Comment>full name: MAD homolog 2 (Drosophila)</Comment>
    <Graphics CenterX="3064.0673828125" CenterY="1552.8021240234375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="17126" />
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  <DataNode TextLabel="Tgfbr1" GraphId="n188" Type="GeneProduct">
    <Comment>full name: transforming growth factor, beta receptor I / ALK5</Comment>
    <Graphics CenterX="3083.51416015625" CenterY="1259.089111328125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="21812" />
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  <DataNode TextLabel="Nodal" GraphId="n189" Type="GeneProduct">
    <Comment>full name: Nodal homolog</Comment>
    <Graphics CenterX="3318.57177734375" CenterY="1038.9576416015625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="18119" />
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  <DataNode TextLabel="Hnrnpu" GraphId="n19" Type="GeneProduct">
    <Comment>full name: heterogeneous nuclear ribonucleoprotein U </Comment>
    <Graphics CenterX="8383.309204101562" CenterY="3700.5316162109375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="51810" />
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  <DataNode TextLabel="Fgfr1" GraphId="n190" Type="GeneProduct">
    <Comment>full name: fibroblast growth factor receptor 1</Comment>
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    <Xref Database="Entrez Gene" ID="14182" />
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  <DataNode TextLabel="Bmp4" GraphId="n191" Type="GeneProduct">
    <Comment>full name: bone morphogenetic protein 4</Comment>
    <Graphics CenterX="4881.375244140625" CenterY="1034.91552734375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="12159" />
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  <DataNode TextLabel="Acvr1" GraphId="n192" Type="GeneProduct">
    <Comment>full name: activin A receptor, type 1</Comment>
    <Graphics CenterX="4881.16162109375" CenterY="1259.9769287109375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="11477" />
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  <DataNode TextLabel="Smad1" GraphId="n193" Type="GeneProduct">
    <Comment>full name: MAD homolog 1 (Drosophila)</Comment>
    <Graphics CenterX="4880.80224609375" CenterY="1380.421142578125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="17125" />
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  <DataNode TextLabel="Cdh1" GraphId="n194" Type="GeneProduct">
    <Comment>full name: cadherin 1</Comment>
    <Graphics CenterX="4106.772216796875" CenterY="1759.79931640625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="12550" />
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  <DataNode TextLabel="Ctnnb1" GraphId="n195" Type="GeneProduct">
    <Comment>full name: catenin (cadherin associated protein), beta 1</Comment>
    <Graphics CenterX="3966.39990234375" CenterY="1852.3221435546875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="12387" />
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  <DataNode TextLabel="Tcf3" GraphId="n196" Type="GeneProduct">
    <Comment>full name: transcription factor 3</Comment>
    <Graphics CenterX="3970.117919921875" CenterY="1984.5831298828125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="21415" />
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  <DataNode TextLabel="Itgb1" GraphId="n197" Type="GeneProduct">
    <Comment>full name: integrin beta 1 (fibronectin receptor beta)</Comment>
    <Graphics CenterX="7210.713562011719" CenterY="1155.9698486328125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="16412" />
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  <DataNode TextLabel="Gsk3b" GraphId="n198" Type="GeneProduct">
    <Comment>full name: glycogen synthase kinase 3 beta</Comment>
    <Graphics CenterX="3965.151611328125" CenterY="1521.1795654296875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="56637" />
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  <DataNode TextLabel="Dvl1" GraphId="n199" Type="GeneProduct">
    <Comment>full name: dishevelled, dsh homolog 1 (Drosophila)</Comment>
    <Graphics CenterX="3966.748779296875" CenterY="1397.890625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="13542" />
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  <DataNode TextLabel="Hdac4" GraphId="n2" Type="GeneProduct">
    <Comment>full name: histone deacetylase 4</Comment>
    <Graphics CenterX="1711.58447265625" CenterY="3647.1074829101562" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="208727" />
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  <DataNode TextLabel="Phf17" GraphId="n20" Type="GeneProduct">
    <Comment>full name: PHD finger protein 17</Comment>
    <Graphics CenterX="3847.41015625" CenterY="3944.02294921875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="269424" />
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  <DataNode TextLabel="Fzd1" GraphId="n200" Type="GeneProduct">
    <Comment>full name: frizzled homolog 1 (Drosophila)  </Comment>
    <Graphics CenterX="3965.058837890625" CenterY="1258.7767333984375" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="14362" />
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  <DataNode TextLabel="Lrp5" GraphId="n201" Type="GeneProduct">
    <Comment>full name: low density lipoprotein receptor-related protein 5</Comment>
    <Graphics CenterX="3869.7353515625" CenterY="1207.1270751953125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="16973" />
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  <DataNode TextLabel="Wnt3a" GraphId="n202" Type="GeneProduct">
    <Comment>full name: wingless-related MMTV integration site 3A</Comment>
    <Graphics CenterX="3966.265869140625" CenterY="1149.05712890625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="22416" />
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  <DataNode TextLabel="Ptpn11" GraphId="n203" Type="GeneProduct">
    <Comment>full name: protein tyrosine phosphatase, non-receptor type 11</Comment>
    <Graphics CenterX="7530.2728271484375" CenterY="1397.6689453125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="19247" />
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  <DataNode TextLabel="Grb2" GraphId="n204" Type="GeneProduct">
    <Comment>full name: growthfactorreceptor-boundprotein2</Comment>
    <Graphics CenterX="6323.44921875" CenterY="1254.057373046875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="14784" />
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  <DataNode TextLabel="Zfp42" GraphId="n205" Type="GeneProduct">
    <Comment>full name: zinc finger protein 42</Comment>
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    <Xref Database="Entrez Gene" ID="22702" />
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  <DataNode TextLabel="Ep300" GraphId="n206" Type="GeneProduct">
    <Comment>full name: E1A binding protein p300</Comment>
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    <Xref Database="Entrez Gene" ID="328572" />
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  <DataNode TextLabel="Utf1" GraphId="n207" Type="GeneProduct">
    <Comment>full name: undifferentiated embryonic cell transcription factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="22286" />
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  <DataNode TextLabel="Esrrb" GraphId="n208" Type="GeneProduct">
    <Comment>full name: estrogen related receptor, beta</Comment>
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    <Xref Database="Entrez Gene" ID="26380" />
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  <DataNode TextLabel="Phc1" GraphId="n209" Type="GeneProduct">
    <Comment>full name: polyhomeotic-like 1 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="13619" />
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  <DataNode TextLabel="Zic2" GraphId="n21" Type="GeneProduct">
    <Comment>full name: zinc finger protein of the cerebellum 2</Comment>
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    <Xref Database="Entrez Gene" ID="22772" />
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  <DataNode TextLabel="Etv5" GraphId="n210" Type="GeneProduct">
    <Comment>full name: ets variant gene 5</Comment>
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    <Xref Database="Entrez Gene" ID="104156" />
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  <DataNode TextLabel="Tcfap2c" GraphId="n211" Type="GeneProduct">
    <Comment>full name: transcription factor AP-2, gamma</Comment>
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    <Xref Database="Entrez Gene" ID="21420" />
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  <DataNode TextLabel="Otx2" GraphId="n212" Type="GeneProduct">
    <Comment>full name: orthodenticle homolog 2 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="18424" />
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  <DataNode TextLabel="Zfp219" GraphId="n213" Type="GeneProduct">
    <Comment>full name: zinc finger protein 219</Comment>
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    <Xref Database="Entrez Gene" ID="69890" />
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  <DataNode TextLabel="Rybp" GraphId="n214" Type="GeneProduct">
    <Comment>full name: RING1 and YY1 binding protein</Comment>
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    <Xref Database="Entrez Gene" ID="56353" />
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  <DataNode TextLabel="Tle4" GraphId="n215" Type="GeneProduct">
    <Comment>full name: Transducin-likeenhancerofsplit4</Comment>
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    <Xref Database="Entrez Gene" ID="21888" />
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  <DataNode TextLabel="Rbpj" GraphId="n216" Type="GeneProduct">
    <Comment>full name: recombination signal binding protein for immunoglobulin kappa J region</Comment>
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    <Xref Database="Entrez Gene" ID="19664" />
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  <DataNode TextLabel="Sall1" GraphId="n217" Type="GeneProduct">
    <Comment>full name: sal-like 1 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="58198" />
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  <DataNode TextLabel="Fos" GraphId="n218" Type="GeneProduct">
    <Comment>full name: FBJ osteosarcoma oncogene</Comment>
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    <Xref Database="Entrez Gene" ID="14281" />
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  <DataNode TextLabel="Paf1" GraphId="n219" Type="GeneProduct">
    <Comment>full name: Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)</Comment>
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    <Xref Database="Entrez Gene" ID="54624" />
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  <DataNode TextLabel="Tcfe3" GraphId="n22" Type="GeneProduct">
    <Comment>full name: transcription factor E3</Comment>
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    <Xref Database="Entrez Gene" ID="209446" />
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  <DataNode TextLabel="Kat5" GraphId="n220" Type="GeneProduct">
    <Comment>full name: K(lysine) acetyltransferase 5</Comment>
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    <Xref Database="Entrez Gene" ID="81601" />
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  <DataNode TextLabel="Sos1" GraphId="n221" Type="GeneProduct">
    <Comment>full name: Son of sevenless homolog 1 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="20662" />
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  <DataNode TextLabel="Inhbb" GraphId="n222" Type="GeneProduct">
    <Comment>full name: inhibin beta-B</Comment>
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    <Xref Database="Entrez Gene" ID="16324" />
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  <DataNode TextLabel="Tgfb1" GraphId="n223" Type="GeneProduct">
    <Comment>full name: transforming growth factor, beta 1</Comment>
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    <Xref Database="Entrez Gene" ID="21803" />
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  <DataNode TextLabel="Smad7" GraphId="n224" Type="GeneProduct">
    <Comment>full name: MADhomolog7</Comment>
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    <Xref Database="Entrez Gene" ID="17131" />
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  <DataNode TextLabel="Ewsr1" GraphId="n225" Type="GeneProduct">
    <Comment>full name: Ewing sarcoma breakpoint region 1</Comment>
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    <Xref Database="Entrez Gene" ID="14030" />
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  <DataNode TextLabel="Smarcc1" GraphId="n226" Type="GeneProduct">
    <Comment>full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1</Comment>
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    <Xref Database="Entrez Gene" ID="20588" />
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  <DataNode TextLabel="Parp1" GraphId="n227" Type="GeneProduct">
    <Comment>full name: poly (ADP-ribose) polymerase family, member 1</Comment>
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    <Xref Database="Entrez Gene" ID="11545" />
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  <DataNode TextLabel="Ctcf" GraphId="n228" Type="GeneProduct">
    <Comment>full name: CCCTC-binding factor</Comment>
    <Graphics CenterX="1948.26123046875" CenterY="4879.020263671875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="13018" />
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  <DataNode TextLabel="Tsix" GraphId="n229" Type="GeneProduct">
    <Comment>full name: X (inactive)-specific transcript, antisense</Comment>
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    <Xref Database="Entrez Gene" ID="22097" />
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  <DataNode TextLabel="Mitf" GraphId="n23" Type="GeneProduct">
    <Comment>full name: microphthalmia-associated transcription factor</Comment>
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    <Xref Database="Entrez Gene" ID="17342" />
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  <DataNode TextLabel="Xite" GraphId="n230" Type="GeneProduct">
    <Comment>full name: X-inactivation intergenic transcription element   </Comment>
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    <Xref Database="Entrez Gene" ID="619209" />
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  <DataNode TextLabel="Kdm4c" GraphId="n231" Type="GeneProduct">
    <Comment>full name: lysine (K)-specific demethylase 4C</Comment>
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    <Xref Database="Entrez Gene" ID="76804" />
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  <DataNode TextLabel="Kdm3a" GraphId="n232" Type="GeneProduct">
    <Comment>full name: lysine (K)-specific demethylase 3A</Comment>
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    <Xref Database="Entrez Gene" ID="104263" />
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  <DataNode TextLabel="Zfp57" GraphId="n233" Type="GeneProduct">
    <Comment>full name: zinc finger protein 57</Comment>
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    <Xref Database="Entrez Gene" ID="22715" />
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  <DataNode TextLabel="Kpna2" GraphId="n234" Type="GeneProduct">
    <Comment>full name: karyopherin (importin) alpha 2</Comment>
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    <Xref Database="Entrez Gene" ID="16647" />
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  <DataNode TextLabel="Casp3" GraphId="n235" Type="GeneProduct">
    <Comment>full name: caspase 3</Comment>
    <Graphics CenterX="5281.186279296875" CenterY="1910.2197265625" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="12367" />
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  <DataNode TextLabel="Rtn4r" GraphId="n236" Type="GeneProduct">
    <Comment>full name: reticulon 4 receptor</Comment>
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    <Xref Database="Entrez Gene" ID="65079" />
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  <DataNode TextLabel="Cd44" GraphId="n237" Type="GeneProduct">
    <Comment>full name: CD44 antigen</Comment>
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    <Xref Database="Entrez Gene" ID="12505" />
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  <DataNode TextLabel="Mapk1" GraphId="n238" Type="GeneProduct">
    <Comment>full name: mitogen-activated protein kinase 1</Comment>
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    <Xref Database="Entrez Gene" ID="26413" />
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  <DataNode TextLabel="Nme2" GraphId="n239" Type="GeneProduct">
    <Comment>full name: non-metastatic cells 2, protein (NM23B) expressed in</Comment>
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    <Xref Database="Entrez Gene" ID="18103" />
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  <DataNode TextLabel="Tcfeb" GraphId="n24" Type="GeneProduct">
    <Comment>full name: transcription factor EB</Comment>
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    <Xref Database="Entrez Gene" ID="21425" />
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  <DataNode TextLabel="Ehmt2" GraphId="n240" Type="GeneProduct">
    <Comment>full name: euchromatic histone lysine N-methyltransferase 2</Comment>
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    <Xref Database="Entrez Gene" ID="110147" />
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  <DataNode TextLabel="Dnmt3l" GraphId="n241" Type="GeneProduct">
    <Comment>full name: DNA (cytosine-5-)-methyltransferase 3-like</Comment>
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    <Xref Database="Entrez Gene" ID="54427" />
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  <DataNode TextLabel="Irs1" GraphId="n242" Type="GeneProduct">
    <Comment>full name: insulin receptor substrate 1</Comment>
    <Graphics CenterX="5759.260009765625" CenterY="1375.7774658203125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="16367" />
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  <DataNode TextLabel="Insr" GraphId="n243" Type="GeneProduct">
    <Comment>full name: insulin receptor</Comment>
    <Graphics CenterX="5759.771484375" CenterY="1151.5430908203125" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="16337" />
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  <DataNode TextLabel="Ins1" GraphId="n244" Type="GeneProduct">
    <Comment>full name: insulin I</Comment>
    <Graphics CenterX="5759.164794921875" CenterY="983.40966796875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="16333" />
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  <DataNode TextLabel="Shh" GraphId="n245" Type="GeneProduct">
    <Comment>full name: sonic hedgehog</Comment>
    <Graphics CenterX="8330.640258789062" CenterY="2604.841796875" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="20423" />
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  <DataNode TextLabel="Smo" GraphId="n246" Type="GeneProduct">
    <Comment>full name: smoothened homolog (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="319757" />
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  <DataNode TextLabel="Ehmt1" GraphId="n247" Type="GeneProduct">
    <Comment>full name: euchromatic histone methyltransferase 1</Comment>
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    <Xref Database="Entrez Gene" ID="77683" />
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  <DataNode TextLabel="Gadd45gip1" GraphId="n248" Type="GeneProduct">
    <Comment>full name: growth arrest and DNA-damage-inducible, gamma interacting protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="102060" />
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  <DataNode TextLabel="Ncoa1" GraphId="n249" Type="GeneProduct">
    <Comment>full name: nuclear receptor coactivator 1</Comment>
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    <Xref Database="Entrez Gene" ID="17977" />
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  <DataNode TextLabel="Ctbp2" GraphId="n25" Type="GeneProduct">
    <Comment>full name: C-terminal binding protein 2</Comment>
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    <Xref Database="Entrez Gene" ID="13017" />
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  <DataNode TextLabel="Prkaca" GraphId="n250" Type="GeneProduct">
    <Comment>full name: protein kinase, cAMP dependent, catalytic, alpha</Comment>
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    <Xref Database="Entrez Gene" ID="18747" />
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  <DataNode TextLabel="Dnmt3a" GraphId="n251" Type="GeneProduct">
    <Comment>full name: DNA methyltransferase 3A</Comment>
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    <Xref Database="Entrez Gene" ID="13435" />
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  <DataNode TextLabel="Dnmt3b" GraphId="n252" Type="GeneProduct">
    <Comment>full name: DNA methyltransferase 3B</Comment>
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    <Xref Database="Entrez Gene" ID="13436" />
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  <DataNode TextLabel="Tcfap2a" GraphId="n253" Type="GeneProduct">
    <Comment>full name: transcription factor AP-2, alpha</Comment>
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    <Xref Database="Entrez Gene" ID="21418" />
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  <DataNode TextLabel="Satb1" GraphId="n254" Type="GeneProduct">
    <Comment>full name: special AT-rich sequence binding protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="20230" />
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  <DataNode TextLabel="Satb2" GraphId="n255" Type="GeneProduct">
    <Comment>full name: special AT-rich sequence binding protein 2</Comment>
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    <Xref Database="Entrez Gene" ID="212712" />
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  <DataNode TextLabel="Pax6" GraphId="n256" Type="GeneProduct">
    <Comment>full name: paired box gene 6</Comment>
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    <Xref Database="Entrez Gene" ID="77766" />
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  <DataNode TextLabel="Spp1" GraphId="n257" Type="GeneProduct">
    <Comment>full name: secreted phosphoprotein 1</Comment>
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    <Xref Database="Entrez Gene" ID="20750" />
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  <DataNode TextLabel="Pias4" GraphId="n258" Type="GeneProduct">
    <Comment>full name: protein inhibitor of activated STAT 4; PIASy</Comment>
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    <Xref Database="Entrez Gene" ID="59004" />
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  <DataNode TextLabel="Wwp2" GraphId="n259" Type="GeneProduct">
    <Comment>full name: WW domain containing E3 ubiquitin protein ligase 2</Comment>
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    <Xref Database="Entrez Gene" ID="66894" />
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  <DataNode TextLabel="Creb1" GraphId="n26" Type="GeneProduct">
    <Comment>full name: cAMP responsive element binding protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="12912" />
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  <DataNode TextLabel="Uhrf1" GraphId="n260" Type="GeneProduct">
    <Comment>full name: ubiquitin-like, containing PHD and RING finger domains, 1</Comment>
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  <DataNode TextLabel="Rcn2" GraphId="n261" Type="GeneProduct">
    <Comment>full name: reticulocalbin 2</Comment>
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    <Xref Database="Entrez Gene" ID="26611" />
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  <DataNode TextLabel="Stk40" GraphId="n262" Type="GeneProduct">
    <Comment>full name: serine/threonine kinase 40</Comment>
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    <Xref Database="Entrez Gene" ID="74178" />
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  <DataNode TextLabel="Fgf5" GraphId="n263" Type="GeneProduct">
    <Comment>full name: fibroblast growth factor 5</Comment>
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    <Xref Database="Entrez Gene" ID="14176" />
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  <DataNode TextLabel="Dazl" GraphId="n264" Type="GeneProduct">
    <Comment>full name: deleted in azoospermia-like</Comment>
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    <Xref Database="Entrez Gene" ID="13164" />
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  <DataNode TextLabel="Grsf1" GraphId="n265" Type="GeneProduct">
    <Comment>full name: G-rich RNA sequence binding factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="231413" />
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  <DataNode TextLabel="Aes" GraphId="n266" Type="GeneProduct">
    <Comment>full name: amino-terminal enhancer of split</Comment>
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  <DataNode TextLabel="Pim1" GraphId="n267" Type="GeneProduct">
    <Comment>full name: proviral integration site 1</Comment>
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  <DataNode TextLabel="Pim3" GraphId="n268" Type="GeneProduct">
    <Comment>full name: proviral integration site 3</Comment>
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  <DataNode TextLabel="Ocln" GraphId="n269" Type="GeneProduct">
    <Comment>full name: occludin</Comment>
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  <DataNode TextLabel="Atf2" GraphId="n27" Type="GeneProduct">
    <Comment>full name: activating transcription factor 2</Comment>
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    <Xref Database="Entrez Gene" ID="11909" />
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  <DataNode TextLabel="Icam1" GraphId="n270" Type="GeneProduct">
    <Comment>full name: intercellular adhesion molecule 1</Comment>
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    <Xref Database="Entrez Gene" ID="15894" />
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  <DataNode TextLabel="Brca1" GraphId="n271" Type="GeneProduct">
    <Comment>full name: breast cancer 1</Comment>
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    <Xref Database="Entrez Gene" ID="12189" />
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  <DataNode TextLabel="Sumo1" GraphId="n272" Type="GeneProduct">
    <Comment>full name: SMT3 suppressor of mif two 3 homolog 1 (yeast)</Comment>
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    <Xref Database="Entrez Gene" ID="22218" />
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  <DataNode TextLabel="Tet1" GraphId="n273" Type="GeneProduct">
    <Comment>full name: tet oncogene 1</Comment>
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    <Xref Database="Entrez Gene" ID="52463" />
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  <DataNode TextLabel="T" GraphId="n274" Type="GeneProduct">
    <Comment>full name: brachyury</Comment>
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    <Xref Database="Entrez Gene" ID="20997" />
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  <DataNode TextLabel="Gbx2" GraphId="n275" Type="GeneProduct">
    <Comment>full name: gastrulation brain homeobox 2</Comment>
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  <DataNode TextLabel="Nr2f6" GraphId="n276" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 2, group F, member 6  </Comment>
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  <DataNode TextLabel="Nr2c1" GraphId="n277" Type="GeneProduct">
    <Comment>full name: nuclear receptor subfamily 2, group C, member 1</Comment>
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    <Xref Database="Entrez Gene" ID="22025" />
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  <DataNode TextLabel="Sf1" GraphId="n278" Type="GeneProduct">
    <Comment>full name: splicing factor 1</Comment>
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    <Xref Database="Entrez Gene" ID="22668" />
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  <DataNode TextLabel="Usp7" GraphId="n279" Type="GeneProduct">
    <Comment>full name: ubiquitin specific peptidase 7   </Comment>
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    <Xref Database="Entrez Gene" ID="252870" />
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  <DataNode TextLabel="Cabin1" GraphId="n28" Type="GeneProduct">
    <Comment>full name: calcineurin binding protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="104248" />
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  <DataNode TextLabel="Pin1" GraphId="n280" Type="GeneProduct">
    <Comment>full name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1</Comment>
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    <Xref Database="Entrez Gene" ID="23988" />
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  <DataNode TextLabel="Rock1" GraphId="n281" Type="GeneProduct">
    <Comment>full name: Rho-associated coiled-coil containing protein kinase 1</Comment>
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    <Xref Database="Entrez Gene" ID="19877" />
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  <DataNode TextLabel="Rock2" GraphId="n282" Type="GeneProduct">
    <Comment>full name: Rho-associated coiled-coil containing protein kinase 2</Comment>
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    <Xref Database="Entrez Gene" ID="19878" />
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  <DataNode TextLabel="Prkcc" GraphId="n283" Type="GeneProduct">
    <Comment>full name: protein kinase C, gamma</Comment>
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    <Xref Database="Entrez Gene" ID="18752" />
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  <DataNode TextLabel="E130012A19Rik" GraphId="n284" Type="GeneProduct">
    <Comment>full name: RIKEN cDNA E130012A19 gene</Comment>
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    <Xref Database="Entrez Gene" ID="103551" />
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  <DataNode TextLabel="Igfbp3" GraphId="n285" Type="GeneProduct">
    <Comment>full name: insulin-like growth factor binding protein 3</Comment>
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    <Xref Database="Entrez Gene" ID="16009" />
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  <DataNode TextLabel="Bcam" GraphId="n286" Type="GeneProduct">
    <Comment>full name: basal cell adhesion molecule</Comment>
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    <Xref Database="Entrez Gene" ID="57278" />
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  <DataNode TextLabel="1600029D21Rik" GraphId="n287" Type="GeneProduct">
    <Comment>full name: RIKEN cDNA 1600029D21 gene</Comment>
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    <Xref Database="Entrez Gene" ID="76509" />
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  <DataNode TextLabel="Perp" GraphId="n288" Type="GeneProduct">
    <Comment>full name: PERP, TP53 apoptosis effector</Comment>
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    <Xref Database="Entrez Gene" ID="64058" />
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  <DataNode TextLabel="Dgka" GraphId="n289" Type="GeneProduct">
    <Comment>full name: diacylglycerol kinase, alpha</Comment>
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    <Xref Database="Entrez Gene" ID="13139" />
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  <DataNode TextLabel="Hira" GraphId="n29" Type="GeneProduct">
    <Comment>full name: histone cell cycle regulation defective homolog A (S. cerevisiae)</Comment>
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    <Xref Database="Entrez Gene" ID="15260" />
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  <DataNode TextLabel="Fam129a" GraphId="n290" Type="GeneProduct">
    <Comment>full name: family with sequence similarity 129, member A</Comment>
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    <Xref Database="Entrez Gene" ID="63913" />
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  <DataNode TextLabel="Hck" GraphId="n291" Type="GeneProduct">
    <Comment>full name: hemopoietic cell kinase</Comment>
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    <Xref Database="Entrez Gene" ID="15162" />
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  <DataNode TextLabel="Acvr1c" GraphId="n3" Type="GeneProduct">
    <Comment>full name: activin A receptor, type IC / Alk7</Comment>
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    <Xref Database="Entrez Gene" ID="269275" />
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  <DataNode TextLabel="Smarca5" GraphId="n30" Type="GeneProduct">
    <Comment>full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5</Comment>
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    <Xref Database="Entrez Gene" ID="93762" />
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  <DataNode TextLabel="Ssrp1" GraphId="n31" Type="GeneProduct">
    <Comment>full name: structure specific recognition protein 1</Comment>
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    <Xref Database="Entrez Gene" ID="20833" />
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  <DataNode TextLabel="Sall3" GraphId="n32" Type="GeneProduct">
    <Comment>full name: sal-like 3 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="20689" />
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  <DataNode TextLabel="Chd4" GraphId="n33" Type="GeneProduct">
    <Comment>full name: chromodomain helicase DNA binding protein 4</Comment>
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    <Xref Database="Entrez Gene" ID="107932" />
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  <DataNode TextLabel="H3f3a" GraphId="n34" Type="GeneProduct">
    <Comment>full name: H3 histone, family 3A</Comment>
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    <Xref Database="Entrez Gene" ID="15078" />
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  <DataNode TextLabel="Atrx" GraphId="n35" Type="GeneProduct">
    <Comment>full name: alpha thalassemia/mental retardation syndrome X-linked homolog (human)</Comment>
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    <Xref Database="Entrez Gene" ID="22589" />
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  <DataNode TextLabel="Nkd1" GraphId="n36" Type="GeneProduct">
    <Comment>full name: naked cuticle 1 homolog (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="93960" />
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  <DataNode TextLabel="Ppp2r1a" GraphId="n37" Type="GeneProduct">
    <Comment>full name: protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform</Comment>
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    <Xref Database="Entrez Gene" ID="51792" />
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  <DataNode TextLabel="Nobox" GraphId="n38" Type="GeneProduct">
    <Comment>full name: NOBOX oogenesis homeobox</Comment>
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    <Xref Database="Entrez Gene" ID="18291" />
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  <DataNode TextLabel="Gdf9" GraphId="n39" Type="GeneProduct">
    <Comment>full name: growth differentiation factor 9</Comment>
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    <Xref Database="Entrez Gene" ID="14566" />
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  <DataNode TextLabel="Acvr1b" GraphId="n4" Type="GeneProduct">
    <Comment>full name: activin A receptor, type 1B  / Alk4</Comment>
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    <Xref Database="Entrez Gene" ID="11479" />
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  <DataNode TextLabel="Mtf2" GraphId="n40" Type="GeneProduct">
    <Comment>full name: metal response element binding transcription factor 2 / PCL2</Comment>
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    <Xref Database="Entrez Gene" ID="17765" />
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  <DataNode TextLabel="Rbbp4" GraphId="n41" Type="GeneProduct">
    <Comment>full name: retinoblastoma binding protein 4</Comment>
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    <Xref Database="Entrez Gene" ID="19646" />
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  <DataNode TextLabel="Rbbp7" GraphId="n42" Type="GeneProduct">
    <Comment>full name: retinoblastoma binding protein 7</Comment>
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    <Xref Database="Entrez Gene" ID="245688" />
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  <DataNode TextLabel="Suz12" GraphId="n43" Type="GeneProduct">
    <Comment>full name: suppressor of zeste 12 homolog (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="52615" />
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  <DataNode TextLabel="Jarid2" GraphId="n44" Type="GeneProduct">
    <Comment>full name: jumonji, AT rich interactive domain 2</Comment>
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    <Xref Database="Entrez Gene" ID="16468" />
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  <DataNode TextLabel="Nppb" GraphId="n45" Type="GeneProduct">
    <Comment>full name: natriuretic peptide precursor type B</Comment>
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    <Xref Database="Entrez Gene" ID="18158" />
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  <DataNode TextLabel="Npr1" GraphId="n46" Type="GeneProduct">
    <Comment>full name: natriuretic peptide receptor 1</Comment>
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    <Xref Database="Entrez Gene" ID="18160" />
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  <DataNode TextLabel="Cad" GraphId="n47" Type="GeneProduct">
    <Comment>full name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase</Comment>
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    <Xref Database="Entrez Gene" ID="69719" />
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  <DataNode TextLabel="Dffa" GraphId="n48" Type="GeneProduct">
    <Comment>full name: DNA fragmentation factor, alpha subunit</Comment>
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    <Xref Database="Entrez Gene" ID="13347" />
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  <DataNode TextLabel="Ezh2" GraphId="n49" Type="GeneProduct">
    <Comment>full name: enhancer of zeste homolog 2 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="14056" />
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  <DataNode TextLabel="Smad3" GraphId="n5" Type="GeneProduct">
    <Comment>full name: MAD homolog 3 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="17127" />
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  <DataNode TextLabel="Ezh1" GraphId="n50" Type="GeneProduct">
    <Comment>full name: enhancer of zeste homolog 1 (Drosophila)</Comment>
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    <Xref Database="Entrez Gene" ID="14055" />
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  <DataNode TextLabel="Eed" GraphId="n51" Type="GeneProduct">
    <Comment>full name: embryonic ectoderm development</Comment>
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    <Xref Database="Entrez Gene" ID="13626" />
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  <DataNode TextLabel="Ipo7" GraphId="n52" Type="GeneProduct">
    <Comment>full name: importin 7</Comment>
    <Graphics CenterX="3420.11669921875" CenterY="2927.348129272461" Width="60.0" Height="60.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval" />
    <Xref Database="Entrez Gene" ID="233726" />
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  <DataNode TextLabel="Kpnb1" GraphId="n53" Type="GeneProduct">
    <Comment>full name: karyopherin (importin) beta 1</Comment>
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    <Comment>full name: exportin 4</Comment>
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    <Comment>full name: importin 9</Comment>
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    <Comment>full name: trans-acting transcription factor 3</Comment>
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    <Comment>full name: telomeric repeat binding factor 2</Comment>
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    <Comment>full name: heart and neural crest derivatives expressed transcript 2</Comment>
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    <Comment>full name: dihydropyrimidinase-like 2</Comment>
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    <Comment>full name: lysine (K)-specific demethylase 5C</Comment>
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    <Comment>full name: KDM1 lysine (K)-specific demethylase 6B</Comment>
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    <Comment>full name: myeloid/lymphoid or mixed-lineage leukemia 2, ALR</Comment>
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    <Comment>full name: 4lysine (K)-specific demethylase 6A</Comment>
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    <Comment>full name: myocyte enhancer factor 2C</Comment>
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    <Comment>full name: myocyte enhancer factor 2D</Comment>
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    <Comment>full name: myogenic differentiation 1</Comment>
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    <Comment>full name: SMAD specific E3 ubiquitin protein ligase 1</Comment>
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    <Comment>full name: serum/glucocorticoid regulated kinase 1</Comment>
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  <DataNode TextLabel="Nedd4l" GraphId="n68" Type="GeneProduct">
    <Comment>full name: neural precursor cell expressed, developmentally down-regulated gene 4-like</Comment>
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    <Comment>full name: hypoxia inducible factor 1, alpha subunit</Comment>
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  <DataNode TextLabel="Dppa4" GraphId="n7" Type="GeneProduct">
    <Comment>full name: developmental pluripotency associated 4</Comment>
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    <Comment>full name: Kruppel-like factor 2 (lung)</Comment>
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  <DataNode TextLabel="Hells" GraphId="n71" Type="GeneProduct">
    <Comment>full name: helicase, lymphoid specific</Comment>
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    <Comment>full name: DNA methyltransferase (cytosine-5) 1</Comment>
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  <DataNode TextLabel="Ctr9" GraphId="n73" Type="GeneProduct">
    <Comment>full name: Ctr9 (Alco called "SH2 domain-binding protein 1")</Comment>
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  <DataNode TextLabel="Leo1" GraphId="n74" Type="GeneProduct">
    <Comment>full name: Leo1</Comment>
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  <DataNode TextLabel="Cdc73" GraphId="n75" Type="GeneProduct">
    <Comment>full name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog</Comment>
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  <DataNode TextLabel="Wdr61" GraphId="n76" Type="GeneProduct">
    <Comment>full name: WD repeat domain 61</Comment>
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  <DataNode TextLabel="Carm1" GraphId="n77" Type="GeneProduct">
    <Comment>full name: coactivator-associated arginine methyltransferase 1</Comment>
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  <DataNode TextLabel="Rbl2" GraphId="n78" Type="GeneProduct">
    <Comment>full name: retinoblastoma-like 2</Comment>
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  <DataNode TextLabel="Cdk2" GraphId="n79" Type="GeneProduct">
    <Comment>full name: cyclin-dependent kinase 2</Comment>
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  <DataNode TextLabel="Relb" GraphId="n8" Type="GeneProduct">
    <Comment>full name: avian reticuloendotheliosis viral (v-rel) oncogene related B</Comment>
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    <Comment>full name: SET domain, bifurcated 1</Comment>
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    <Comment>full name: nucleolin</Comment>
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  <DataNode TextLabel="Lyar" GraphId="n82" Type="GeneProduct">
    <Comment>full name: Ly1 antibody reactive clone</Comment>
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    <Comment>full name: tripartite motif-containing 24</Comment>
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    <Comment>full name: twist gene homolog 1 (Drosophila)</Comment>
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    <Comment>full name: zinc finger and SCAN domain containing 10</Comment>
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    <Comment>full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2</Comment>
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    <Comment>full name: promyelocytic leukemia</Comment>
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    <Comment>full name: lysine (K)-specific demethylase 1A</Comment>
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    <Comment>full name: GATA zinc finger domain containing 2A</Comment>
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    <Comment>full name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)</Comment>
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    <Comment>full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4</Comment>
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    <Comment>full name: GATA zinc finger domain containing 2B</Comment>
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    <Comment>full name: polybromo 1 / BAF180</Comment>
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    <Comment>full name: histone deacetylase 1</Comment>
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    <Comment>full name: metastasis associated 1</Comment>
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    <Comment>full name: Kruppel-like factor 5</Comment>
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    <Comment>full name: transducin-like enhancer of split 2, homolog of Drosophila E(spl)</Comment>
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