<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Proteasome degradation" Data-Source="WikiPathways" Version="WP519_r141445" Author="[Nsalomonis, MaintBot, Ddigles, Mkutmon, Eweitz, Egonw, Ash iyer, DeSl]" Last-Modified="20251114151839" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases.
Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Proteasome).</Comment>
  <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP183_r95110 WP183 (r95110)] with a 89.0% conversion rate.</Comment>
  <BiopaxRef>e91</BiopaxRef>
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  <DataNode TextLabel="Psmb10" GraphId="a05" Type="GeneProduct" GroupRef="ae142">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5699</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMB10 | proteasome (prosome macropain) subuni..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000031897" />
  </DataNode>
  <DataNode TextLabel="Ubc" GraphId="a09" Type="GeneProduct" GroupRef="ecb14">
    <Comment Source="HomologyMapper">No homologues found for original id L:7316</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UBC | ubiquitin C" />
    <Graphics CenterX="276.66666666666663" CenterY="76.40833333333329" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22190" />
  </DataNode>
  <DataNode TextLabel="Hist1h2an" GraphId="a11" Type="GeneProduct" GroupRef="f26af">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8335</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HIST1H2AB | histone 1 H2ab" />
    <Graphics CenterX="121.99833333333336" CenterY="101.20583333333326" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000069309" />
  </DataNode>
  <DataNode TextLabel="Uchl4" GraphId="a116a" Type="GeneProduct" GroupRef="ddd03">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000118939</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UCHL3 | Ubiquitin carboxy terminal hydrolase 3" />
    <Graphics CenterX="127.50391666666667" CenterY="646.4321666666652" Width="60.0" Height="19.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000035337" />
  </DataNode>
  <DataNode TextLabel="Psma2" GraphId="a13" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5683</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMA2 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="509.5238095238096" CenterY="468.77754086709314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000015671" />
  </DataNode>
  <DataNode TextLabel="Ubiquitin" GraphId="a1e7b" Type="Protein">
    <Comment Source="HomologyMapper">No homologues found for original id S:P0CG48</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UBC | ubiquitin C" />
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    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="H2-Q10" GraphId="a25" Type="GeneProduct" GroupRef="bb4df">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3135</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HLA-G | HLA-G histocompatibility antigen class..." />
    <Graphics CenterX="470.0" CenterY="813.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000067235" />
  </DataNode>
  <DataNode TextLabel="Psme1" GraphId="ae8" Type="GeneProduct" GroupRef="a791b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5720</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSME1 | proteasome (prosome macropain) activat..." />
    <Graphics CenterX="796.6666666666666" CenterY="247.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022216" />
  </DataNode>
  <DataNode TextLabel="Psmb1" GraphId="b21" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5689</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMB1 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="626.1904761904761" CenterY="448.77754086709314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000014769" />
  </DataNode>
  <DataNode TextLabel="Psma5" GraphId="b71" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5686</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMA5 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="509.5238095238096" CenterY="528.7775408670931" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000068749" />
  </DataNode>
  <DataNode TextLabel="H2-Q10" GraphId="b82" Type="GeneProduct" GroupRef="bb4df">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3133</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HLA-E | major histocompatibility complex class..." />
    <Graphics CenterX="360.0" CenterY="853.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000067235" />
  </DataNode>
  <DataNode TextLabel="Psmd12" GraphId="ba6" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5718</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD12 | proteasome (prosome macropain) 26S su..." />
    <Graphics CenterX="336.3333333333333" CenterY="583.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020720" />
  </DataNode>
  <DataNode TextLabel="Psmd9" GraphId="bbe" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5715</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD9 | proteasome (prosome macropain) 26S sub..." />
    <Graphics CenterX="336.3333333333333" CenterY="523.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029440" />
  </DataNode>
  <DataNode TextLabel="Psmc5" GraphId="bd0" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="GenMAPP remarks">PRS6 HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5705</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMC5 | proteasome (prosome macropain) 26S sub..." />
    <Graphics CenterX="216.33333333333334" CenterY="503.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020708" />
  </DataNode>
  <DataNode TextLabel="Ube2b" GraphId="bfa" Type="GeneProduct" GroupRef="e6e44">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7320</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UBE2B | ubiquitin-conjugating enzyme E2B (RAD6 ..." />
    <Graphics CenterX="381.86295833333304" CenterY="42.88179166666663" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020390" />
  </DataNode>
  <DataNode TextLabel="Psmb8" GraphId="c0c" Type="GeneProduct" GroupRef="ae142">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5696</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMB8 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="796.6666666666666" CenterY="512.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024338" />
  </DataNode>
  <DataNode TextLabel="Psmd7" GraphId="c12" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5713</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD7 | proteasome (prosome macropain) 26S sub..." />
    <Graphics CenterX="336.3333333333333" CenterY="483.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000039067" />
  </DataNode>
  <DataNode TextLabel="Psmb4" GraphId="c1d" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5692</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMB4 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="626.1904761904761" CenterY="508.77754086709314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000005779" />
  </DataNode>
  <DataNode TextLabel="Ube2d3" GraphId="c25" Type="GeneProduct" GroupRef="e6e44">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7323</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UB..." />
    <Graphics CenterX="381.86295833333304" CenterY="102.88179166666659" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000078578" />
  </DataNode>
  <DataNode TextLabel="Psmd11" GraphId="c26" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5717</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD11 | proteasome (prosome macropain) 26S su..." />
    <Graphics CenterX="336.3333333333333" CenterY="563.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000017428" />
  </DataNode>
  <DataNode TextLabel="Uba1" GraphId="c5c" Type="GeneProduct" GroupRef="aa4b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7317</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UBE1 | ubiquitin-activating enzyme E1 (A1S9T an..." />
    <Graphics CenterX="166.13566355721406" CenterY="280.4763143656719" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000001924" />
  </DataNode>
  <DataNode TextLabel="Rpn1" GraphId="c76" Type="GeneProduct" GroupRef="d69b8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6184</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPN1 | ribophorin I" />
    <Graphics CenterX="88.10337499999997" CenterY="491.49366666666646" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030062" />
  </DataNode>
  <DataNode TextLabel="Psmc3" GraphId="c87" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5702</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMC3 | proteasome (prosome macropain) 26S sub..." />
    <Graphics CenterX="216.33333333333334" CenterY="463.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000002102" />
  </DataNode>
  <DataNode TextLabel="H2afz" GraphId="cb2" Type="GeneProduct" GroupRef="f26af">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3015</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="H2AFZ | H2A histone family member Z" />
    <Graphics CenterX="121.99833333333336" CenterY="141.20583333333343" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000037894" />
  </DataNode>
  <DataNode TextLabel="Psmb2" GraphId="cd9" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5690</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMB2 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="626.1904761904761" CenterY="468.77754086709314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000028837" />
  </DataNode>
  <DataNode TextLabel="HLA-H" GraphId="cf0" Type="GeneProduct" GroupRef="bb4df">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HLA-H | major histocompatibility complex class..." />
    <Graphics CenterX="470.0" CenterY="833.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Psmb9" GraphId="cf9" Type="GeneProduct" GroupRef="ae142">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5698</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMB9 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="796.6666666666666" CenterY="532.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000096727" />
  </DataNode>
  <DataNode TextLabel="Ifng" GraphId="d19" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3458</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG | interferon gamma" />
    <Graphics CenterX="796.6666666666666" CenterY="356.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000055170" />
  </DataNode>
  <DataNode TextLabel="Psma3" GraphId="d29" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5684</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMA3 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="509.5238095238096" CenterY="488.77754086709314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000060073" />
  </DataNode>
  <DataNode TextLabel="Uchl1" GraphId="d836b" Type="GeneProduct" GroupRef="ddd03">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000154277</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UCHL1 | Ubiquitin Carboxy terminal hydrolase 1" />
    <Graphics CenterX="127.50391666666667" CenterY="627.4321666666652" Width="60.0" Height="19.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029223" />
  </DataNode>
  <DataNode TextLabel="H2-Q10" GraphId="d95" Type="GeneProduct" GroupRef="bb4df">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3105</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HLA-A | major histocompatibility complex class..." />
    <Graphics CenterX="360.0" CenterY="793.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000067235" />
  </DataNode>
  <DataNode TextLabel="Psmd10" GraphId="d96" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">No homologues found for original id L:5716</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD10 | proteasome (prosome macropain) 26S su..." />
    <Graphics CenterX="336.3333333333333" CenterY="543.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="53380" />
  </DataNode>
  <DataNode TextLabel="HLA-J" GraphId="da5" Type="GeneProduct" GroupRef="bb4df">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HLA-J | major histocompatibility complex class..." />
    <Graphics CenterX="470.0" CenterY="853.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="H2-Q10" GraphId="dbc" Type="GeneProduct" GroupRef="bb4df">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3134</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HLA-F | major histocompatibility complex class..." />
    <Graphics CenterX="470.0" CenterY="793.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000067235" />
  </DataNode>
  <DataNode TextLabel="Psmd3" GraphId="dc6" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5709</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD3 | proteasome (prosome macropain) 26S sub..." />
    <Graphics CenterX="216.33333333333334" CenterY="583.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000017221" />
  </DataNode>
  <DataNode TextLabel="Psmd13" GraphId="dda" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5719</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD13 | proteasome (prosome macropain) 26S su..." />
    <Graphics CenterX="336.3333333333333" CenterY="603.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025487" />
  </DataNode>
  <DataNode TextLabel="Ube2d2a" GraphId="ddc" Type="GeneProduct" GroupRef="e6e44">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7322</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="UBE2D2 | ubiquitin-conjugating enzyme E2D 2 (UB..." />
    <Graphics CenterX="381.86295833333304" CenterY="82.88179166666653" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000091896" />
  </DataNode>
  <DataNode TextLabel="Rpn2" GraphId="de2" Type="GeneProduct" GroupRef="d69b8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6185</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPN2 | ribophorin II" />
    <Graphics CenterX="88.10337499999997" CenterY="511.49366666666646" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027642" />
  </DataNode>
  <DataNode TextLabel="H2afx" GraphId="dec" Type="GeneProduct" GroupRef="f26af">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3014</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="H2AFX | H2A histone family member X" />
    <Graphics CenterX="121.99833333333336" CenterY="121.20583333333325" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000049932" />
  </DataNode>
  <DataNode TextLabel="Psmd6" GraphId="ded" Type="GeneProduct" GroupRef="cce91">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9861</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMD6 | proteasome (prosome macropain) 26S sub..." />
    <Graphics CenterX="336.3333333333333" CenterY="463.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021737" />
  </DataNode>
  <DataNode TextLabel="Psma7" GraphId="e1c" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5688</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMA7 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="509.5238095238096" CenterY="568.7775408670931" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027566" />
  </DataNode>
  <DataNode TextLabel="Psma1" GraphId="e24" Type="GeneProduct" GroupRef="d6bc1">
    <Comment Source="HomologyMapper">No homologues found for original id L:5682</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PSMA1 | proteasome (prosome macropain) subunit..." />
    <Graphics CenterX="509.5238095238096" CenterY="448.77754086709314" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="26440" />
  </DataNode>
  <DataNode TextLabel="Uba7" GraphId="e53" Type="GeneProduct" GroupRef="aa4b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7318</Comment>
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