<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Folic acid network" Data-Source="WikiPathways" Version="WP1273_r140335" Author="[MaintBot, Khanspers, Samuel Sklar, Egonw, Christine Chichester, Laurent, Eweitz, AlexanderPico, Larsgw]" Last-Modified="20250811150428" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome. 
</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP176&amp;amp;amp;amp;oldid=30153 WP176(r30153)] with a 58% conversion rate.</Comment>
  <Graphics BoardWidth="2021.4529914529917" BoardHeight="1801.8717383314959" />
  <DataNode TextLabel="Zinc" GraphId="a0466" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Zinc" />
    <Graphics CenterX="1738.0" CenterY="253.16666666666666" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0015532" />
  </DataNode>
  <DataNode TextLabel="Ptges" GraphId="a0a86" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ptges" />
    <Graphics CenterX="1697.3166666666666" CenterY="754.65" Width="44.7" Height="18.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="64292" />
  </DataNode>
  <DataNode TextLabel="Vitamin B12" GraphId="a0ad8" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Vitamin B12 / Cyanocobalamin" />
    <Graphics CenterX="472.5" CenterY="634.4833333333333" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000607" />
  </DataNode>
  <DataNode TextLabel="L-Glutamic acid" GraphId="a1f2f" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="L-Glutamic acid" />
    <Graphics CenterX="477.48333333333335" CenterY="155.98333333333332" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000148" />
  </DataNode>
  <DataNode TextLabel="PGI2" GraphId="a1fea" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin I2" />
    <Graphics CenterX="1435.0" CenterY="1304.65" Width="47.333333333333336" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Lipoic acid" GraphId="a2ea6" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lipoic acid" />
    <Graphics CenterX="1752.9833333333333" CenterY="111.98333333333333" Width="86.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001451" />
  </DataNode>
  <DataNode TextLabel="Homocysteine" GraphId="a3c06" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Homocysteine" />
    <Graphics CenterX="640.9833333333333" CenterY="558.9833333333333" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000742" />
  </DataNode>
  <DataNode TextLabel="Cobalamin" GraphId="a3de1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cobalamin" />
    <Graphics CenterX="348.15" CenterY="711.3333333333334" Width="71.03333333333333" Height="26.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0002174" />
  </DataNode>
  <DataNode TextLabel="Ptgis" GraphId="a471f" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ptgis" />
    <Graphics CenterX="1430.4833333333333" CenterY="823.4833333333333" Width="39.03333333333333" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="19223" />
  </DataNode>
  <DataNode TextLabel="DHA (n-3)" GraphId="a647e" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Docosahexaenoic acid" />
    <Graphics CenterX="1770.3333333333333" CenterY="1334.5" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0002183" />
  </DataNode>
  <DataNode TextLabel="Uric acid" GraphId="a69da" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Uric acid" />
    <Graphics CenterX="1153.9833333333333" CenterY="140.98333333333332" Width="73.36666666666666" Height="22.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000289" />
  </DataNode>
  <DataNode TextLabel="Glycine" GraphId="a6b24" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glycine" />
    <Graphics CenterX="878.1666666666666" CenterY="1315.6666666666667" Width="67.0" Height="28.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000123" />
  </DataNode>
  <DataNode TextLabel="B" GraphId="a71a2">
    <Graphics CenterX="545.0" CenterY="1562.6666666666667" Width="20.0" Height="18.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Tryptophan" GraphId="a73fd" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Tryptophan" />
    <Graphics CenterX="1380.8166666666666" CenterY="332.5" Width="58.36666666666667" Height="21.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000929" />
  </DataNode>
  <DataNode TextLabel="Endoperoxidase" GraphId="a7c7a" Type="Protein">
    <Graphics CenterX="1699.9833333333333" CenterY="699.3166666666667" Width="90.7" Height="24.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Gpx6" GraphId="a80db" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gpx6" />
    <Graphics CenterX="811.4833333333333" CenterY="288.65" Width="65.03333333333333" Height="14.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="75512" />
  </DataNode>
  <DataNode TextLabel="Leukotriene B4" GraphId="a8206" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene B4" />
    <Graphics CenterX="1001.0" CenterY="718.3166666666667" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001085" />
  </DataNode>
  <DataNode TextLabel="Homocysteine" GraphId="a849a" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Homocysteine" />
    <Graphics CenterX="619.3166666666667" CenterY="1282.3166666666666" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="SOD" GraphId="a9489" Type="Protein">
    <Graphics CenterX="1463.3333333333333" CenterY="225.65" Width="57.333333333333336" Height="24.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="LeukotrieneE4" GraphId="a9a24" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene E4" />
    <Graphics CenterX="1130.0" CenterY="1354.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0002200" />
  </DataNode>
  <DataNode TextLabel="a-tocopherol" GraphId="ac0d5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Alpha tocopherol" />
    <Graphics CenterX="1638.3333333333333" CenterY="1436.3333333333333" Width="79.33333333333333" Height="26.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0001893" />
  </DataNode>
  <DataNode TextLabel="Pyridoxal-5'-phosphate" GraphId="ac9a8" Type="Metabolite">
    <BiopaxRef>b89</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pyridoxal-5'-phosphate / Vitamin B6" />
    <Graphics CenterX="889.6666666666666" CenterY="454.81666666666666" Width="117.33333333333333" Height="26.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001491" />
  </DataNode>
  <DataNode TextLabel="S-Adenosylhomocysteine " GraphId="ad3de" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="S-Adenosylhomocysteine " />
    <Graphics CenterX="448.48333333333335" CenterY="491.98333333333335" Width="125.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000939" />
  </DataNode>
  <DataNode TextLabel="Fads2" GraphId="ad8ba" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Fads2" />
    <Graphics CenterX="1703.1666666666667" CenterY="498.15" Width="77.0" Height="27.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="56473" />
  </DataNode>
  <DataNode TextLabel="PGG2" GraphId="adc69" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin G2" />
    <Graphics CenterX="1569.65" CenterY="682.65" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0003235" />
  </DataNode>
  <DataNode TextLabel="Cbs" GraphId="adf9b" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cbs" />
    <Graphics CenterX="662.5" CenterY="493.15" Width="33.0" Height="21.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="12411" />
  </DataNode>
  <DataNode TextLabel="Nicotinamide" GraphId="ae9b5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nicotinamide" />
    <Graphics CenterX="1477.3166666666666" CenterY="493.5" Width="70.7" Height="26.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="936" />
  </DataNode>
  <DataNode TextLabel="Glutathione" GraphId="aedad" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glutathione" />
    <Graphics CenterX="782.65" CenterY="1331.65" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000125" />
  </DataNode>
  <DataNode TextLabel="Copper" GraphId="afb23" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Copper" />
    <Graphics CenterX="1761.0" CenterY="1475.8333333333333" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000657" />
  </DataNode>
  <DataNode TextLabel="15-HETE" GraphId="b00f5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="5-Hydroxyeicosatetraenoic acid" />
    <Graphics CenterX="1260.3166666666666" CenterY="614.5" Width="50.7" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0011134" />
  </DataNode>
  <DataNode TextLabel="Lipoxin A4" GraphId="b040e" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lipoxin A4" />
    <Graphics CenterX="1205.1666666666667" CenterY="1311.3166666666666" Width="57.666666666666664" Height="24.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0004385" />
  </DataNode>
  <DataNode TextLabel="Adipic acid " GraphId="b0460" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Adipic acid" />
    <Graphics CenterX="285.98333333333335" CenterY="1365.65" Width="60.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000448" />
  </DataNode>
  <DataNode TextLabel="Pyridoxal-5'-phosphate" GraphId="b09c3" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pyridoxal-5'-phosphate / Vitamin B6" />
    <Graphics CenterX="894.3166666666667" CenterY="1255.8166666666666" Width="115.36666666666666" Height="24.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001491" />
  </DataNode>
  <DataNode TextLabel="S-Adenosylmethionine " GraphId="b0c7d" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="S-Adenosylmethionine " />
    <Graphics CenterX="202.81666666666666" CenterY="1329.3166666666666" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001185" />
  </DataNode>
  <DataNode TextLabel="Calcium" GraphId="b0d0c" Type="Metabolite">
    <BiopaxRef>c93</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Calcium" />
    <Graphics CenterX="198.33333333333334" CenterY="636.9833333333333" Width="88.0" Height="24.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0000464" />
  </DataNode>
  <DataNode TextLabel="Leukotriene C4" GraphId="b1edc" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene C4" />
    <Graphics CenterX="1104.0" CenterY="722.3166666666667" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001198" />
  </DataNode>
  <DataNode TextLabel="Leukotriene C4" GraphId="b22b8" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene C4" />
    <Graphics CenterX="1059.3333333333333" CenterY="1270.9833333333333" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001198" />
  </DataNode>
  <DataNode TextLabel="Manganese" GraphId="b24a2" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Manganese" />
    <Graphics CenterX="1759.3166666666666" CenterY="210.31666666666666" Width="73.36666666666666" Height="16.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001333" />
  </DataNode>
  <DataNode TextLabel="LA (n-6)" GraphId="b28eb" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Linoleic acid" />
    <Graphics CenterX="1557.5" CenterY="1403.9833333333333" Width="61.666666666666664" Height="30.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000673" />
  </DataNode>
  <DataNode TextLabel="Adipic acid" GraphId="b3cf1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Adipic acid" />
    <Graphics CenterX="293.31666666666666" CenterY="258.98333333333335" Width="60.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000448" />
  </DataNode>
  <DataNode TextLabel="LA (n-6)" GraphId="b3f90" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Linoleic acid" />
    <Graphics CenterX="1574.1666666666667" CenterY="564.3333333333334" Width="51.0" Height="23.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000673" />
  </DataNode>
  <DataNode TextLabel="S-Adenosylmethionine" GraphId="b428f" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="S-Adenosylmethionine" />
    <Graphics CenterX="225.15" CenterY="491.98333333333335" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001185" />
  </DataNode>
  <DataNode TextLabel="Txnrd2" GraphId="b4839" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Txnrd2" />
    <Graphics CenterX="894.65" CenterY="69.65" Width="73.0" Height="16.700000000000003" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="26462" />
  </DataNode>
  <DataNode TextLabel="Choline" GraphId="b4d47" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Choline" />
    <Graphics CenterX="454.98333333333335" CenterY="381.65" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000097" />
  </DataNode>
  <DataNode TextLabel="Methionine sulfoxide" GraphId="b6335" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Methionine sulfoxide" />
    <Graphics CenterX="243.81666666666666" CenterY="363.65" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0002005" />
  </DataNode>
  <DataNode TextLabel="Ascorbic acid" GraphId="b7acf" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ascorbic acid / Vitamin " />
    <Graphics CenterX="1843.3333333333333" CenterY="1429.1666666666667" Width="80.0" Height="24.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000044" />
  </DataNode>
  <DataNode TextLabel="d4 desaturase" GraphId="b83e1" Type="Protein">
    <Graphics CenterX="1701.3166666666666" CenterY="817.6666666666666" Width="76.03333333333333" Height="23.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Transcobalamin" GraphId="b850a" Type="Protein">
    <Graphics CenterX="349.6666666666667" CenterY="636.9833333333333" Width="88.0" Height="24.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="PGH3" GraphId="bb747" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin H3" />
    <Graphics CenterX="1843.9833333333333" CenterY="804.3166666666667" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="L-Methionine" GraphId="bbffd" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="L-Methionine" />
    <Graphics CenterX="225.98333333333332" CenterY="559.9833333333333" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000696" />
  </DataNode>
  <DataNode TextLabel="Methylmalonic acid" GraphId="bc28c" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Methylmalonic acid" />
    <Graphics CenterX="290.48333333333335" CenterY="164.31666666666666" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000202" />
  </DataNode>
  <DataNode TextLabel="Uric acid" GraphId="bc5e9" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Uric acid" />
    <Graphics CenterX="1149.3166666666666" CenterY="1443.0" Width="73.36666666666666" Height="25.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000289" />
  </DataNode>
  <DataNode TextLabel="Methylmalonic acid " GraphId="bd16d" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Methylmalonic acid " />
    <Graphics CenterX="288.15" CenterY="1474.3166666666666" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000202" />
  </DataNode>
  <DataNode TextLabel="Cat" GraphId="bd36d" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cat" />
    <Graphics CenterX="1092.8333333333333" CenterY="486.5" Width="55.666666666666664" Height="17.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="12359" />
  </DataNode>
  <DataNode TextLabel="Thromboxane A2" GraphId="be821" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Thromboxane A2" />
    <Graphics CenterX="1255.8333333333333" CenterY="862.9833333333333" Width="83.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001452" />
  </DataNode>
  <DataNode TextLabel="Ascorbic acid" GraphId="be91c" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ascorbic acid / Vitamin C" />
    <Graphics CenterX="1849.3333333333333" CenterY="157.16666666666666" Width="80.0" Height="24.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000044" />
  </DataNode>
  <DataNode TextLabel="PGI2" GraphId="bedf5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin I2" />
    <Graphics CenterX="1431.3333333333333" CenterY="888.3166666666667" Width="47.333333333333336" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001335" />
  </DataNode>
  <DataNode TextLabel="PGG3" GraphId="bf6b1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="prostaglandin G3" />
    <Graphics CenterX="1843.65" CenterY="756.65" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="C22:5 (n-6)" GraphId="bfd5d" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Docosapentaenoic acid" />
    <Graphics CenterX="1620.1666666666667" CenterY="848.65" Width="61.0" Height="20.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001976" />
  </DataNode>
  <DataNode TextLabel="Methionine" GraphId="c0d03" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Methionine" />
    <Graphics CenterX="217.98333333333332" CenterY="1294.9833333333333" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000696" />
  </DataNode>
  <DataNode TextLabel="Mthfr" GraphId="c0da9" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mthfr" />
    <Graphics CenterX="1166.65" CenterY="389.15" Width="52.7" Height="20.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="17769" />
  </DataNode>
  <DataNode TextLabel="Leukotriene A4" GraphId="c0f26" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene A4" />
    <Graphics CenterX="1059.8166666666666" CenterY="662.1666666666666" Width="83.03333333333333" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001337" />
  </DataNode>
  <DataNode TextLabel="Kmo" GraphId="c1f0f" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Kmo" />
    <Graphics CenterX="1258.9833333333333" CenterY="340.3333333333333" Width="52.7" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="98256" />
  </DataNode>
  <DataNode TextLabel="NADPH" GraphId="c313f" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nicotinamide adenine dinucleotide phosphate" />
    <Graphics CenterX="1372.9833333333333" CenterY="267.3333333333333" Width="52.7" Height="21.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000221" />
  </DataNode>
  <DataNode TextLabel="Iron" GraphId="c37b8" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Iron" />
    <Graphics CenterX="1262.3333333333333" CenterY="1454.5" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000692" />
  </DataNode>
  <DataNode TextLabel="Lipoxin A4" GraphId="c380d" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lipoxin A4" />
    <Graphics CenterX="1211.8333333333333" CenterY="682.65" Width="57.666666666666664" Height="24.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0004385" />
  </DataNode>
  <DataNode TextLabel="FAD" GraphId="c40f2" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Flavin adenine dinucleotide" />
    <Graphics CenterX="1171.65" CenterY="336.48333333333335" Width="52.7" Height="24.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="703" />
  </DataNode>
  <DataNode TextLabel="Thromboxane B2" GraphId="c4c25" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Thromboxane B2" />
    <Graphics CenterX="1257.8333333333333" CenterY="906.9833333333333" Width="83.0" Height="18.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0003252" />
  </DataNode>
  <DataNode TextLabel="Leukotriene D4" GraphId="c4ce9" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene D4" />
    <Graphics CenterX="1105.0" CenterY="765.65" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0003080" />
  </DataNode>
  <DataNode TextLabel="Gpx2" GraphId="c5239" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gpx2" />
    <Graphics CenterX="811.4833333333333" CenterY="245.65" Width="65.03333333333333" Height="14.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="14776" />
  </DataNode>
  <DataNode TextLabel="S-Adenosylhomocysteine " GraphId="c6123" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="S-Adenosylhomocysteine " />
    <Graphics CenterX="438.48333333333335" CenterY="1368.3166666666666" Width="125.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000939" />
  </DataNode>
  <DataNode TextLabel="FMN1" GraphId="c61c3" Type="GeneProduct">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Riboflavin kinase" />
    <Graphics CenterX="1092.3166666666666" CenterY="335.15" Width="52.7" Height="20.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="342184" />
  </DataNode>
  <DataNode TextLabel="Ptgds" GraphId="c65a6" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ptgds" />
    <Graphics CenterX="1499.4833333333333" CenterY="822.8166666666667" Width="39.03333333333333" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="19215" />
  </DataNode>
  <DataNode TextLabel="Selk" GraphId="c73f2" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Selk" />
    <Graphics CenterX="730.9833333333333" CenterY="179.98333333333332" Width="52.03333333333333" Height="24.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="80795" />
  </DataNode>
  <DataNode TextLabel="Sepw1" GraphId="c78fe" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Sepw1" />
    <Graphics CenterX="994.65" CenterY="102.98333333333333" Width="52.03333333333333" Height="24.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="20364" />
  </DataNode>
  <DataNode TextLabel="Gpx3" GraphId="c84b1" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gpx3" />
    <Graphics CenterX="811.4833333333333" CenterY="260.65" Width="65.03333333333333" Height="14.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="14778" />
  </DataNode>
  <DataNode TextLabel="Cysteine" GraphId="caef5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cysteine" />
    <Graphics CenterX="696.65" CenterY="348.98333333333335" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000574" />
  </DataNode>
  <DataNode TextLabel="Carnitine" GraphId="cb9d1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Carnitine" />
    <Graphics CenterX="454.65" CenterY="325.31666666666666" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000062" />
  </DataNode>
  <DataNode TextLabel="Mtr" GraphId="cc574" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mtr" />
    <Graphics CenterX="458.6666666666667" CenterY="556.8166666666667" Width="58.0" Height="23.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="238505" />
  </DataNode>
  <DataNode TextLabel="Selenium" GraphId="cd01e" Type="Metabolite">
    <BiopaxRef>ec3</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Selenium" />
    <Graphics CenterX="880.3166666666667" CenterY="187.31666666666666" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0001349" />
  </DataNode>
  <DataNode TextLabel="AA (n-6)" GraphId="cd60e" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Arachidonic acid" />
    <Graphics CenterX="1609.5" CenterY="1352.65" Width="61.666666666666664" Height="22.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001043" />
  </DataNode>
  <DataNode TextLabel="B" GraphId="cf22e" Type="GeneProduct">
    <Graphics CenterX="948.5" CenterY="177.16666666666666" Width="15.0" Height="13.666666666666666" ZOrder="32768" FontSize="10" Valign="Middle" Color="ffcc00" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="5-HPETE" GraphId="cfa4d" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value=": 5(S)-Hydroperoxyeicosatetraenoic acid" />
    <Graphics CenterX="1184.65" CenterY="611.1666666666666" Width="55.36666666666667" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001193" />
  </DataNode>
  <DataNode TextLabel="Riboflavin" GraphId="cfbd0" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Riboflavin / Vitamin B2" />
    <Graphics CenterX="941.3166666666667" CenterY="341.31666666666666" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0000244" />
  </DataNode>
  <DataNode TextLabel="Betaine" GraphId="d0cb7" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Betaine" />
    <Graphics CenterX="454.31666666666666" CenterY="444.65" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000043" />
  </DataNode>
  <DataNode TextLabel="NADP" GraphId="d0dc2" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nicotinamide adenine dinucleotide phosphate" />
    <Graphics CenterX="1346.65" CenterY="300.0" Width="52.7" Height="21.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000217" />
  </DataNode>
  <DataNode TextLabel="Tromboxane A2" GraphId="d13d7" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Tromboxane A2" />
    <Graphics CenterX="1260.1666666666667" CenterY="1371.65" Width="83.0" Height="16.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001452" />
  </DataNode>
  <DataNode TextLabel="TT" GraphId="d15cd">
    <Graphics CenterX="545.0" CenterY="1660.6666666666667" Width="20.0" Height="18.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="TRXR 3" GraphId="d4676" Type="Protein">
    <Graphics CenterX="894.65" CenterY="85.65" Width="73.0" Height="16.700000000000003" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Alox5" GraphId="d5323" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Alox5" />
    <Graphics CenterX="1220.0" CenterY="432.3333333333333" Width="43.333333333333336" Height="20.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="11689" />
  </DataNode>
  <DataNode TextLabel="O₂" GraphId="d5fac" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Oxygen" />
    <Graphics CenterX="1121.4833333333333" CenterY="449.81666666666666" Width="41.03333333333333" Height="15.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001377" />
  </DataNode>
  <DataNode TextLabel="Leukotriene F4" GraphId="d6520" Type="Metabolite">
    <BiopaxRef>bbd</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene F4" />
    <Graphics CenterX="1106.6666666666667" CenterY="856.65" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="F2-Isoprostane" GraphId="d6c91" Type="Metabolite">
    <BiopaxRef>a62</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="F2-Isoprostane" />
    <Graphics CenterX="1365.3333333333333" CenterY="520.8333333333334" Width="78.66666666666667" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0004659" />
  </DataNode>
  <DataNode TextLabel="COX1" GraphId="d72f6" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="COX1" />
    <Graphics CenterX="1700.4833333333333" CenterY="602.8166666666667" Width="39.03333333333333" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="3337205" />
  </DataNode>
  <DataNode TextLabel="1-methylnicotinamide" GraphId="d8a07" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="1-methylnicotinamide" />
    <Graphics CenterX="1509.65" CenterY="1470.5" Width="112.7" Height="24.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000699" />
  </DataNode>
  <DataNode TextLabel="Sepx1" GraphId="d9175" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Sepx1" />
    <Graphics CenterX="777.9833333333333" CenterY="95.65" Width="52.03333333333333" Height="24.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="27361" />
  </DataNode>
  <DataNode TextLabel="15-HETE" GraphId="d9ca5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="5-Hydroxyeicosatetraenoic acid" />
    <Graphics CenterX="1252.9833333333333" CenterY="1413.8333333333333" Width="50.7" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0011134" />
  </DataNode>
  <DataNode TextLabel="Cysteine" GraphId="d9eb5" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cysteine" />
    <Graphics CenterX="717.65" CenterY="1279.9833333333333" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000574" />
  </DataNode>
  <DataNode TextLabel="Gsr" GraphId="da207" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gsr" />
    <Graphics CenterX="1066.65" CenterY="279.65" Width="49.36666666666667" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031584" />
  </DataNode>
  <DataNode TextLabel="H₂O" GraphId="da359" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Water" />
    <Graphics CenterX="1060.8166666666666" CenterY="450.15" Width="41.03333333333333" Height="15.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0002111" />
  </DataNode>
  <DataNode TextLabel="DHA (n-3)" GraphId="daa47" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Docosahexaenoic acid" />
    <Graphics CenterX="1785.3333333333333" CenterY="860.5" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0002183" />
  </DataNode>
  <DataNode TextLabel="Leukotriene B4" GraphId="db56e" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene B4" />
    <Graphics CenterX="994.3333333333334" CenterY="1342.3166666666666" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001085" />
  </DataNode>
  <DataNode TextLabel="5,10-METHYL-THF" GraphId="dcfb1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="5,10-methylene-tetrahydrofolate" />
    <Graphics CenterX="671.0" CenterY="1435.6666666666667" Width="102.0" Height="34.666666666666664" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001396" />
  </DataNode>
  <DataNode TextLabel="IE" GraphId="dd7fa">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ie" />
    <Graphics CenterX="545.0" CenterY="1625.6666666666667" Width="20.0" Height="18.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Ethanolamine" GraphId="dd89a" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ethanolamine" />
    <Graphics CenterX="781.3333333333334" CenterY="516.15" Width="89.33333333333333" Height="23.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000149" />
  </DataNode>
  <DataNode TextLabel="PGE3" GraphId="ddc41" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value=" Prostaglandin E3" />
    <Graphics CenterX="1842.9833333333333" CenterY="685.3166666666667" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0002664" />
  </DataNode>
  <DataNode TextLabel="ALA (n-3)" GraphId="deae1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="alpha Linolenic acid" />
    <Graphics CenterX="1838.6666666666667" CenterY="529.5" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001388" />
  </DataNode>
  <DataNode TextLabel="FOLIC ACID" GraphId="dfeff" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOLIC ACID" />
    <Graphics CenterX="916.4833333333333" CenterY="554.8333333333334" Width="67.03333333333333" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000121" />
  </DataNode>
  <DataNode TextLabel="Heme" GraphId="e05b1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Heme" />
    <Graphics CenterX="1140.8333333333333" CenterY="543.15" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0003178" />
  </DataNode>
  <DataNode TextLabel="FOLIC ACID" GraphId="e07b6" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOLIC ACID" />
    <Graphics CenterX="913.4833333333333" CenterY="1368.8333333333333" Width="67.03333333333333" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000121" />
  </DataNode>
  <DataNode TextLabel="C22:5 (n-6)" GraphId="e0aa6" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Docosapentaenoic acid" />
    <Graphics CenterX="1624.1666666666667" CenterY="1302.4833333333333" Width="58.333333333333336" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001976" />
  </DataNode>
  <DataNode TextLabel="iPF2-alpha" GraphId="e1384" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="F2-Isoprostane" />
    <Graphics CenterX="1384.0" CenterY="1369.6666666666667" Width="72.66666666666667" Height="27.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0004659" />
  </DataNode>
  <DataNode TextLabel="Thioredoxin" GraphId="e2386" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Thioredoxin" />
    <Graphics CenterX="1645.6666666666667" CenterY="365.65" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="7295" />
  </DataNode>
  <DataNode TextLabel="Serine" GraphId="e2cdf" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Serine" />
    <Graphics CenterX="819.5" CenterY="646.15" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000187" />
  </DataNode>
  <DataNode TextLabel="Copper" GraphId="e3b77" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Copper" />
    <Graphics CenterX="1762.0" CenterY="333.8333333333333" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000657" />
  </DataNode>
  <DataNode TextLabel="PGF2a" GraphId="e3cca" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin F2a" />
    <Graphics CenterX="1275.5" CenterY="1278.8166666666666" Width="53.0" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001139" />
  </DataNode>
  <DataNode TextLabel="LeukotrieneE4" GraphId="e4345" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene E4" />
    <Graphics CenterX="1106.3333333333333" CenterY="809.3166666666667" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0002200" />
  </DataNode>
  <DataNode TextLabel="PGE2" GraphId="e4e7f" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin E2" />
    <Graphics CenterX="1568.65" CenterY="806.9833333333333" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Serine" GraphId="e5d0e" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Serine" />
    <Graphics CenterX="812.1666666666666" CenterY="1486.8166666666666" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000187" />
  </DataNode>
  <DataNode TextLabel="Xanthine" GraphId="e63a2" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Xanthine" />
    <Graphics CenterX="1180.9833333333333" CenterY="198.98333333333332" Width="58.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000292" />
  </DataNode>
  <DataNode TextLabel="Xdh" GraphId="e6c26" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Xdh" />
    <Graphics CenterX="1198.15" CenterY="244.65" Width="51.7" Height="22.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="22436" />
  </DataNode>
  <DataNode TextLabel="Txnrd1" GraphId="e71e5" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Txnrd1" />
    <Graphics CenterX="894.65" CenterY="52.65" Width="73.0" Height="16.700000000000003" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="50493" />
  </DataNode>
  <DataNode TextLabel="a Tocopherol" GraphId="e7346" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Alpha tocopherol" />
    <Graphics CenterX="1618.3333333333333" CenterY="434.31666666666666" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0001893" />
  </DataNode>
  <DataNode TextLabel="EPA (n-3)" GraphId="e7832" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Eicosapentanoic acid  " />
    <Graphics CenterX="1804.6666666666667" CenterY="588.8333333333334" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0001999" />
  </DataNode>
  <DataNode TextLabel="PGF2a" GraphId="e7a84" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin F2a" />
    <Graphics CenterX="1259.1666666666667" CenterY="953.8166666666667" Width="53.0" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001139" />
  </DataNode>
  <DataNode TextLabel="1-Methylnicotinamide" GraphId="e8405" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="1-Methylnicotinamide" />
    <Graphics CenterX="1478.3166666666666" CenterY="396.5" Width="112.7" Height="24.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000699" />
  </DataNode>
  <DataNode TextLabel="NADP" GraphId="e8ddb" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nicotinamide adenine dinucleotide phosphate" />
    <Graphics CenterX="1341.3166666666666" CenterY="1473.0" Width="52.7" Height="21.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000217" />
  </DataNode>
  <DataNode TextLabel="AA (n-6)" GraphId="e987f" Type="Metabolite">
    <BiopaxRef>ff2</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Arachidonic acid" />
    <Graphics CenterX="1572.1666666666667" CenterY="619.3166666666667" Width="57.0" Height="22.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001043" />
  </DataNode>
  <DataNode TextLabel="Cobalamin" GraphId="ea6c0" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cobalamin" />
    <Graphics CenterX="348.48333333333335" CenterY="1332.3333333333333" Width="67.03333333333333" Height="24.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0002174" />
  </DataNode>
  <DataNode TextLabel="Pnpo" GraphId="ea73a" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pnpo" />
    <Graphics CenterX="1084.3166666666666" CenterY="395.81666666666666" Width="52.7" Height="20.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="Entrez Gene" ID="103711" />
  </DataNode>
  <DataNode TextLabel="THAS" GraphId="ea891" Type="Protein">
    <Graphics CenterX="1311.15" CenterY="804.15" Width="39.03333333333333" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="EPA (n-3)" GraphId="ebc71" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Eicosapentanoic acid" />
    <Graphics CenterX="1817.3333333333333" CenterY="1260.5" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001999" />
  </DataNode>
  <DataNode TextLabel="2-Ketobutyric acid" GraphId="ebef3" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="2-Ketobutyric acid" />
    <Graphics CenterX="590.6666666666666" CenterY="1355.8166666666666" Width="98.66666666666667" Height="27.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000005" />
  </DataNode>
  <DataNode TextLabel="PGE2" GraphId="eca8d" Type="Metabolite">
    <Graphics CenterX="1566.65" CenterY="1280.9833333333333" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="H₂O₂" GraphId="ed51b" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Hydrogen peroxide" />
    <Graphics CenterX="1078.3333333333333" CenterY="189.48333333333332" Width="56.0" Height="21.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0003125" />
  </DataNode>
  <DataNode TextLabel="Hypoxanthine" GraphId="edea8" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Hypoxanthine" />
    <Graphics CenterX="1311.3166666666666" CenterY="1330.6666666666667" Width="73.36666666666666" Height="25.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000157" />
  </DataNode>
  <DataNode TextLabel="Lipoxin B4" GraphId="ee113" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lipoxin B4" />
    <Graphics CenterX="1294.8333333333333" CenterY="685.9833333333333" Width="57.666666666666664" Height="24.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0005082" />
  </DataNode>
  <DataNode TextLabel="PGD2" GraphId="ef888" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin D2" />
    <Graphics CenterX="1500.65" CenterY="882.9833333333333" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001403" />
  </DataNode>
  <DataNode TextLabel="Niacin" GraphId="f0848" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Niacin" />
    <Graphics CenterX="1474.3166666666666" CenterY="294.3333333333333" Width="52.7" Height="21.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001406" />
  </DataNode>
  <DataNode TextLabel="Gpx1" GraphId="f0d73" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gpx1" />
    <Graphics CenterX="811.4833333333333" CenterY="232.65" Width="65.03333333333333" Height="14.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="14775" />
  </DataNode>
  <DataNode TextLabel="Ethanolamine" GraphId="f1623" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ethanolamine" />
    <Graphics CenterX="800.6666666666666" CenterY="1386.15" Width="89.33333333333333" Height="23.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000149" />
  </DataNode>
  <DataNode TextLabel="CN" GraphId="f1dd6">
    <Graphics CenterX="545.0" CenterY="1690.6666666666667" Width="20.0" Height="18.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Calcium" GraphId="f26d4" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Calcium" />
    <Graphics CenterX="187.0" CenterY="1413.65" Width="88.0" Height="24.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0000464" />
  </DataNode>
  <DataNode TextLabel="PGH2" GraphId="f2c78" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value=" Prostaglandin H2" />
    <Graphics CenterX="1568.9833333333333" CenterY="755.9833333333333" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001381" />
  </DataNode>
  <DataNode TextLabel="COX2" GraphId="f2d8d" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="COX2" />
    <Graphics CenterX="1697.4833333333333" CenterY="654.8166666666667" Width="39.03333333333333" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="3337209" />
  </DataNode>
  <DataNode TextLabel="T" GraphId="f36b3">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="0" />
    <Graphics CenterX="545.0" CenterY="1592.6666666666667" Width="20.0" Height="18.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="NADPH" GraphId="f3a68" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nicotinamide adenine dinucleotide phosphate" />
    <Graphics CenterX="1371.65" CenterY="1415.0" Width="52.7" Height="21.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000221" />
  </DataNode>
  <DataNode TextLabel="Cystathione" GraphId="f453a" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cystathione" />
    <Graphics CenterX="663.65" CenterY="436.65" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000099" />
  </DataNode>
  <DataNode TextLabel="Glutathione" GraphId="f4ca1" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glutathione" />
    <Graphics CenterX="800.65" CenterY="336.31666666666666" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000125" />
  </DataNode>
  <DataNode TextLabel="PGFS" GraphId="f4e2d" Type="Protein">
    <Graphics CenterX="1362.4833333333333" CenterY="824.15" Width="39.03333333333333" Height="17.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Iron" GraphId="f5384" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Iron" />
    <Graphics CenterX="1244.8333333333333" CenterY="543.4833333333333" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0000692" />
  </DataNode>
  <DataNode TextLabel="d5 desaturase" GraphId="f67de" Type="Protein">
    <Graphics CenterX="1701.8333333333333" CenterY="547.15" Width="77.0" Height="27.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff3300" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="Selenium" GraphId="f6e52" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Selenium" />
    <Graphics CenterX="906.3166666666667" CenterY="1449.3166666666666" Width="84.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="3300ff" />
    <Xref Database="HMDB" ID="HMDB0001349" />
  </DataNode>
  <DataNode TextLabel="Zinc" GraphId="f703c" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Zinc" />
    <Graphics CenterX="1717.0" CenterY="1400.0" Width="56.666666666666664" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0015532" />
  </DataNode>
  <DataNode TextLabel="5,10-METHYL-THF" GraphId="fa622" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="5,10-methylene-tetrahydrofolate" />
    <Graphics CenterX="640.0" CenterY="645.0" Width="116.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001396" />
  </DataNode>
  <DataNode TextLabel="ROS" GraphId="faca8" Type="Metabolite">
    <Comment>http://en.wikipedia.org/wiki/Reactive_oxygen_species</Comment>
    <BiopaxRef>ebb</BiopaxRef>
    <BiopaxRef>f15</BiopaxRef>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Reactive oxygen species" />
    <Graphics CenterX="598.4833333333333" CenterY="156.16666666666666" Width="59.03333333333333" Height="23.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:26523" />
  </DataNode>
  <DataNode TextLabel="2-Ketobutyric acid" GraphId="fb0f0" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="2-Ketobutyric acid" />
    <Graphics CenterX="592.3333333333334" CenterY="352.15" Width="98.66666666666667" Height="27.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000005" />
  </DataNode>
  <DataNode TextLabel="PGD2" GraphId="fc2ff" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prostaglandin D2" />
    <Graphics CenterX="1493.65" CenterY="1346.9833333333333" Width="44.03333333333333" Height="21.366666666666667" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0001403" />
  </DataNode>
  <DataNode TextLabel="Hypoxanthine" GraphId="fca55" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Hypoxanthine" />
    <Graphics CenterX="1317.3166666666666" CenterY="189.65" Width="73.36666666666666" Height="22.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000157" />
  </DataNode>
  <DataNode TextLabel="Gpx4" GraphId="fcd2a" Type="Protein">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gpx4" />
    <Graphics CenterX="811.4833333333333" CenterY="274.65" Width="65.03333333333333" Height="14.7" ZOrder="32768" FontSize="10" Valign="Middle" Color="ff0000" />
    <Xref Database="Entrez Gene" ID="625249" />
  </DataNode>
  <DataNode TextLabel="L-Glutamic acid" GraphId="fce8a" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="L-Glutamic acid" />
    <Graphics CenterX="503.48333333333335" CenterY="1437.3166666666666" Width="123.03333333333333" Height="26.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000148" />
  </DataNode>
  <DataNode TextLabel="ALA (n-3)" GraphId="fe3fb" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="alpha Linolenic acid" />
    <Graphics CenterX="1854.3333333333333" CenterY="1328.1666666666667" Width="56.666666666666664" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001388" />
  </DataNode>
  <DataNode TextLabel="Vitamin B12" GraphId="fea32" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Vitamin B12 / Cyanocobalamin" />
    <Graphics CenterX="469.5" CenterY="1272.8166666666666" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000607" />
  </DataNode>
  <DataNode TextLabel="Leukotriene D4" GraphId="febc4" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Leukotriene D4" />
    <Graphics CenterX="1092.3333333333333" CenterY="1312.65" Width="79.33333333333333" Height="20.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0003080" />
  </DataNode>
  <DataNode TextLabel="Glutathione disulfide" GraphId="fec4e" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glutathione disulfide" />
    <Graphics CenterX="950.3166666666667" CenterY="242.81666666666666" Width="109.36666666666666" Height="33.7" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="65359" />
  </DataNode>
  <DataNode TextLabel="Glycine" GraphId="ffb7c" Type="Metabolite">
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glycine" />
    <Graphics CenterX="878.1666666666666" CenterY="595.4833333333333" Width="67.0" Height="25.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="HMDB" ID="HMDB0000123" />
  </DataNode>
  <Interaction GraphId="a163d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="800.65" Y="323.30000000000007" GraphRef="f4ca1" RelX="0.0" RelY="-1.0" />
      <Point X="811.4833333333333" Y="240.0" GraphRef="f0d73" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2046">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ffcc00">
      <Point X="1007.6583333333333" Y="115.33333333333334" GraphRef="c78fe" RelX="0.5" RelY="1.0" />
      <Point X="821.6583333333333" Y="323.30000000000007" GraphRef="f4ca1" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2b1a">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="242.33333333333334" Y="636.9833333333333" GraphRef="b0d0c" RelX="1.0" RelY="0.0" />
      <Point X="305.6666666666667" Y="636.9833333333333" GraphRef="b850a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2c63">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="290.48333333333335" Y="177.33333333333331" GraphRef="bc28c" RelX="0.0" RelY="1.0" />
      <Point X="289.48333333333335" Y="206.96666666666664" GraphRef="fb112" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2cf8">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1041.9666666666667" Y="279.65" GraphRef="da207" RelX="-1.0" RelY="0.0" />
      <Point X="842.6666666666666" Y="336.3166666666667" GraphRef="f4ca1" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a2fd1">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1005.0000000000002" Y="234.39166666666665" GraphRef="fec4e" RelX="1.0" RelY="-0.5" />
      <Point X="1066.65" Y="266.6333333333333" GraphRef="da207" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a3a9c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="838.3000000000001" Y="180.80833333333334" GraphRef="cd01e" RelX="-1.0" RelY="-0.5" />
      <Point X="757.0" Y="179.98333333333332" GraphRef="c73f2" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a46e7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="243.4833333333333" Y="424.9666666666667" GraphRef="fa621" RelX="0.0" RelY="-1.0" />
      <Point X="243.8166666666667" Y="376.66666666666663" GraphRef="b6335" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a60f7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1211.3333333333333" Y="543.4833333333333" GraphRef="f5384" RelX="-1.0" RelY="0.0" />
      <Point X="1174.3333333333333" Y="543.15" GraphRef="e05b1" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a63cc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1821.8333333333337" Y="517.0" GraphRef="deae1" RelX="-0.5941176470588235" RelY="-1.0" />
      <Point X="1741.6666666666667" Y="491.22499999999997" GraphRef="ad8ba" RelX="1.0" RelY="-0.5" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a6420">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="348.15" Y="724.6666666666665" GraphRef="a3de1" RelX="0.0" RelY="1.0" />
      <Point X="348.48333333333335" Y="1320.0" GraphRef="ea6c0" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a6c34">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1818.8333333333337" Y="601.3333333333334" GraphRef="e7832" RelX="0.5" RelY="1.0" />
      <Point X="1817.3333333333335" Y="1248.0" GraphRef="ebc71" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a762a">
    <BiopaxRef>cbd</BiopaxRef>
    <BiopaxRef>ca8</BiopaxRef>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="472.5" Y="621.9666666666667" GraphRef="a0ad8" RelX="0.0" RelY="-1.0" />
      <Point X="473.1666666666667" Y="568.3333333333334" GraphRef="cc574" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a7c18">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="225.98333333333332" Y="573.0" GraphRef="bbffd" RelX="0.0" RelY="1.0" />
      <Point X="217.98333333333332" Y="1281.9666666666667" GraphRef="c0d03" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a7cec">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1317.3166666666666" Y="178.63333333333333" GraphRef="fca55" RelX="0.0" RelY="-1.0" />
      <Point X="1172.3249999999998" Y="151.99999999999994" GraphRef="a69da" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a8a09">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1104.0" Y="732.6666666666667" GraphRef="b1edc" RelX="0.0" RelY="1.0" />
      <Point X="1105.0" Y="755.3" GraphRef="c4ce9" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="a95f2">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1184.825" Y="324.3" GraphRef="c40f2" RelX="0.5" RelY="-1.0" />
      <Point X="1198.15" Y="256.0" GraphRef="e6c26" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ac3b9">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1638.1666666666663" Y="444.66666666666663" GraphRef="e7346" RelX="0.5" RelY="1.0" />
      <Point X="1638.333333333333" Y="1423.0" GraphRef="ac0d5" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ac4d5">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="819.5" Y="658.6666666666666" GraphRef="e2cdf" RelX="0.0" RelY="1.0" />
      <Point X="812.1666666666666" Y="1474.3" GraphRef="e5d0e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ae107">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1220.0" Y="442.66666666666674" GraphRef="d5323" RelX="0.0" RelY="1.0" />
      <Point X="1294.8333333333335" Y="673.9666666666667" GraphRef="ee113" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ae4a3">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="592.3333333333333" Y="366.0" GraphRef="fb0f0" RelX="0.0" RelY="1.0" />
      <Point X="590.6666666666665" Y="1341.9666666666667" GraphRef="ebef3" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="aeeb4">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1572.1666666666667" Y="630.6666666666667" GraphRef="e987f" RelX="0.0" RelY="1.0" />
      <Point X="1677.9666666666667" Y="654.8166666666667" GraphRef="f2d8d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="af2a5">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1678.3" Y="602.8166666666667" GraphRef="d72f6" RelX="-1.1366353543979504" RelY="0.0" />
      <Point X="1589.0" Y="682.6500000000001" GraphRef="adc69" RelX="0.8788796366389099" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="af4e0">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="268.0" Y="553.475" GraphRef="bbffd" RelX="1.0" RelY="-0.5" />
      <Point X="675.6416666666667" Y="362.0" GraphRef="caef5" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="af87b">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1106.7500000000002" Y="478.0" GraphRef="bd36d" RelX="0.5" RelY="-1.0" />
      <Point X="1121.4833333333333" Y="457.66666666666663" GraphRef="d5fac" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="afddf">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="246.99166666666667" Y="546.9666666666667" GraphRef="bbffd" RelX="0.5" RelY="-1.0" />
      <Point X="243.4833333333333" Y="437.0" GraphRef="fa621" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="aff1f">
    <BiopaxRef>cd4</BiopaxRef>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="ffcc00">
      <Point X="640.0" Y="630.0" GraphRef="fa622" RelX="0.0" RelY="-1.0" />
      <Point X="640.9833333333333" Y="572.0" GraphRef="a3c06" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b06ec">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1301.3916666666669" Y="813.0" GraphRef="ea891" RelX="-0.5" RelY="1.0" />
      <Point X="1278.5833333333333" Y="897.6333333333333" GraphRef="c4c25" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b0f34">
    <BiopaxRef>c1e</BiopaxRef>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="ffcc00">
      <Point X="751.9666666666667" Y="95.65" GraphRef="d9175" RelX="-1.0" RelY="0.0" />
      <Point X="249.99999999999994" Y="430.98333333333335" GraphRef="fa621" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b2765">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="224.4833333333333" Y="519.9666666666667" GraphRef="da14e" RelX="0.0" RelY="-1.0" />
      <Point X="225.14999999999998" Y="505.0" GraphRef="b428f" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b3537">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1385.0000000000002" Y="533.3333333333334" GraphRef="d6c91" RelX="0.5" RelY="1.0" />
      <Point X="1384.0" Y="1356.0" GraphRef="e1384" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b37fb">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1742.666666666667" Y="699.3166666666667" GraphRef="a7c7a" RelX="0.9411980889378905" RelY="0.0" />
      <Point X="1818.9666666666667" Y="756.6500000000001" GraphRef="bf6b1" RelX="-1.12112036336109" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b5129">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1247.6416666666667" Y="605.0" GraphRef="b00f5" RelX="-0.5" RelY="-1.0" />
      <Point X="1230.8333333333333" Y="442.66666666666674" GraphRef="d5323" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b55cd">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="931.15" Y="69.65" GraphRef="b4839" RelX="1.0" RelY="0.0" />
      <Point X="1606.0" Y="365.65" GraphRef="e2386" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b669d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1105.0" Y="776.0" GraphRef="c4ce9" RelX="0.0" RelY="1.0" />
      <Point X="1106.333333333333" Y="798.9666666666667" GraphRef="e4345" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b6bcd">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1106.333333333333" Y="819.6666666666667" GraphRef="e4345" RelX="0.0" RelY="1.0" />
      <Point X="1106.6666666666665" Y="846.3" GraphRef="d6520" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b6e80">
    <BiopaxRef>b83</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="882.9666666666667" Y="554.8333333333334" GraphRef="dfeff" RelX="-1.0" RelY="0.0" />
      <Point X="669.0" Y="630.0" GraphRef="fa622" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b70ff">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1272.4166666666667" Y="962.6666666666667" GraphRef="e7a84" RelX="0.5" RelY="1.0" />
      <Point X="1275.5" Y="1269.9666666666667" GraphRef="e3cca" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b7748">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="246.99166666666667" Y="546.9666666666667" GraphRef="bbffd" RelX="0.5" RelY="-1.0" />
      <Point X="412.30000000000007" Y="444.65" GraphRef="d0cb7" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b77f1">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1543.6666666666667" Y="619.3166666666667" GraphRef="e987f" RelX="-1.0" RelY="0.0" />
      <Point X="1285.6666666666665" Y="614.5" GraphRef="b00f5" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b8d26">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1124.0833333333333" Y="555.6666666666666" GraphRef="e05b1" RelX="-0.5" RelY="1.0" />
      <Point X="1301.3916666666669" Y="795.3" GraphRef="ea891" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b97ce">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ffcc00">
      <Point X="1618.333333333333" Y="444.66666666666663" GraphRef="e7346" RelX="0.0" RelY="1.0" />
      <Point X="1697.4833333333333" Y="645.9666666666667" GraphRef="f2d8d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b9ea1">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="487.6666666666667" Y="556.8166666666667" GraphRef="cc574" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Point X="598.9666666666667" Y="558.9833333333333" GraphRef="a3c06" RelX="-1.0" RelY="0.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b9ebc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="889.6666666666667" Y="468.0" GraphRef="ac9a8" RelX="0.0" RelY="1.0" />
      <Point X="1548.6666666666667" Y="564.3333333333335" GraphRef="b3f90" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ba156">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1586.4166666666667" Y="630.6666666666667" GraphRef="e987f" RelX="0.5" RelY="1.0" />
      <Point X="1594.0833333333333" Y="1341.3000000000002" GraphRef="cd60e" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ba1cc">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1809.3333333333333" Y="157.16666666666669" GraphRef="be91c" RelX="-1.0" RelY="0.0" />
      <Point X="628.0" Y="156.16666666666666" GraphRef="faca8" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ba239">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1084.1666666666667" Y="732.6666666666667" GraphRef="b1edc" RelX="-0.5" RelY="1.0" />
      <Point X="1079.1666666666665" Y="1260.6333333333337" GraphRef="b22b8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ba3a4">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="475.32500000000005" Y="457.66666666666663" GraphRef="d0cb7" RelX="0.5" RelY="1.0" />
      <Point X="473.1666666666667" Y="545.3000000000001" GraphRef="cc574" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ba6bf">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1654.6333333333337" Y="699.3166666666667" GraphRef="a7c7a" RelX="-1.0" RelY="0.0" />
      <Point X="1588.3333333333333" Y="755.9833333333333" GraphRef="f2c78" RelX="0.8788796366389099" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="baae5">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1787.8333333333337" Y="601.3333333333334" GraphRef="e7832" RelX="-0.5941176470588235" RelY="1.0" />
      <Point X="1714.3333333333333" Y="654.8166666666667" GraphRef="f2d8d" RelX="0.8633646456020495" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bb744">
    <BiopaxRef>f1b</BiopaxRef>
    <BiopaxRef>cc4</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="429.6666666666667" Y="556.8166666666667" GraphRef="cc574" RelX="-1.0" RelY="0.0" />
      <Point X="268.0" Y="559.9833333333333" GraphRef="bbffd" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bbe46">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1489.6416666666669" Y="893.6666666666667" GraphRef="ef888" RelX="-0.5" RelY="1.0" />
      <Point X="1493.65" Y="1336.2999999999997" GraphRef="fc2ff" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bc558">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1709.9666666666667" Y="111.98333333333332" GraphRef="a2ea6" RelX="-1.0" RelY="0.0" />
      <Point X="1448.9999999999998" Y="213.3" GraphRef="a9489" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bc8c1">
    <BiopaxRef>cf3</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="511.0" Y="491.98333333333335" GraphRef="ad3de" RelX="1.0" RelY="0.0" />
      <Point X="646.0" Y="493.15" GraphRef="adf9b" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bcecb">
    <BiopaxRef>a58</BiopaxRef>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1709.9666666666667" Y="111.98333333333332" GraphRef="a2ea6" RelX="-1.0" RelY="0.0" />
      <Point X="628.0" Y="156.16666666666666" GraphRef="faca8" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bd073">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="882.9666666666667" Y="546.5833333333334" GraphRef="dfeff" RelX="-1.0" RelY="-0.5" />
      <Point X="803.6666666666669" Y="528.0" GraphRef="dd89a" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bd38f">
    <BiopaxRef>dc8</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ffcc00">
      <Point X="1578.6666666666665" Y="434.3166666666666" GraphRef="e7346" RelX="-1.0" RelY="0.0" />
      <Point X="1241.6666666666665" Y="432.33333333333337" GraphRef="d5323" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bd926">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="717.6583333333333" Y="362.0" GraphRef="caef5" RelX="0.5" RelY="1.0" />
      <Point X="717.65" Y="1266.9666666666667" GraphRef="d9eb5" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bde37">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1050.3333333333333" Y="184.22499999999997" GraphRef="ed51b" RelX="-1.0" RelY="-0.5" />
      <Point X="844.0" Y="245.65" GraphRef="c5239" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bece0">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="950.0" Y="554.8333333333334" GraphRef="dfeff" RelX="1.0" RelY="0.0" />
      <Point X="1107.3333333333333" Y="543.15" GraphRef="e05b1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bfa1c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1085.1666666666667" Y="776.0" GraphRef="c4ce9" RelX="-0.5" RelY="1.0" />
      <Point X="1092.333333333333" Y="1302.3000000000002" GraphRef="febc4" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bfa46">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1849.3333333333333" Y="169.33333333333337" GraphRef="be91c" RelX="0.0" RelY="1.0" />
      <Point X="1843.3333333333333" Y="1417.0" GraphRef="b7acf" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bfa77">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1829.3083333333334" Y="696.0000000000002" GraphRef="ddc41" RelX="-0.6211203633610901" RelY="1.0" />
      <Point X="1742.666666666667" Y="699.3166666666667" GraphRef="a7c7a" RelX="0.9411980889378905" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bfc7b">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1001.0" Y="728.6666666666667" GraphRef="a8206" RelX="0.0" RelY="1.0" />
      <Point X="994.3333333333334" Y="1331.9666666666667" GraphRef="db56e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c07b2">
    <BiopaxRef>a21</BiopaxRef>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="ffcc00">
      <Point X="704.9666666666667" Y="179.98333333333332" GraphRef="c73f2" RelX="-1.0" RelY="0.0" />
      <Point X="628.0" Y="156.16666666666666" GraphRef="faca8" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c0e59">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1220.0" Y="442.66666666666674" GraphRef="d5323" RelX="0.0" RelY="1.0" />
      <Point X="1184.65" Y="601.6666666666666" GraphRef="cfa4d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c1041">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="619.975" Y="545.9666666666667" GraphRef="a3c06" RelX="-0.5" RelY="-1.0" />
      <Point X="583.725" Y="167.66666666666666" GraphRef="faca8" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c1199">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1818.9666666666667" Y="756.6500000000001" GraphRef="bf6b1" RelX="-1.12112036336109" RelY="0.0" />
      <Point X="1717.0" Y="754.65" GraphRef="a0a86" RelX="0.8806860551826995" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c1238">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1157.5833333333333" Y="555.6666666666666" GraphRef="e05b1" RelX="0.5" RelY="1.0" />
      <Point X="1680.9666666666667" Y="602.8166666666667" GraphRef="d72f6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c2829">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="899.725" Y="538.3333333333334" GraphRef="dfeff" RelX="-0.5" RelY="-1.0" />
      <Point X="508.2416666666667" Y="168.99999999999994" GraphRef="a1f2f" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c2d57">
    <BiopaxRef>ed9</BiopaxRef>
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1117.2999999999997" Y="140.9833333333333" GraphRef="a69da" RelX="-1.0" RelY="0.0" />
      <Point X="628.0" Y="156.16666666666666" GraphRef="faca8" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c3a62">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1454.9833333333333" Y="331.0" GraphRef="b624d" RelX="0.0" RelY="-1.0" />
      <Point X="1474.3166666666666" Y="304.9999999999999" GraphRef="f0848" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c463d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1447.9666666666667" Y="294.33333333333326" GraphRef="f0848" RelX="-1.0" RelY="0.0" />
      <Point X="1373.0" Y="300.0" GraphRef="d0dc2" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c49fa">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1126.1666666666663" Y="819.6666666666667" GraphRef="e4345" RelX="0.5" RelY="1.0" />
      <Point X="1130.0" Y="1343.9666666666667" GraphRef="a9a24" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c4a32">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1771.1666666666667" Y="873.0" GraphRef="daa47" RelX="-0.5" RelY="1.0" />
      <Point X="1770.3333333333335" Y="1322.0" GraphRef="a647e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c4b1e">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ffcc00">
      <Point X="348.15" Y="698.0" GraphRef="a3de1" RelX="0.0" RelY="-1.0" />
      <Point X="349.6666666666667" Y="649.0" GraphRef="b850a" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c534d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1714.3333333333333" Y="654.8166666666667" GraphRef="f2d8d" RelX="0.8633646456020495" RelY="0.0" />
      <Point X="1852.6666666666667" Y="694.6666666666666" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c6370">
    <BiopaxRef>dab</BiopaxRef>
    <BiopaxRef>e10</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="393.6666666666667" Y="636.9833333333333" GraphRef="b850a" RelX="1.0" RelY="0.0" />
      <Point X="439.0" Y="634.4833333333333" GraphRef="a0ad8" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c673d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1153.9833333333331" Y="151.99999999999994" GraphRef="a69da" RelX="0.0" RelY="1.0" />
      <Point X="1149.3166666666666" Y="1430.3333333333335" GraphRef="bc5e9" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c6a8f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1574.1666666666667" Y="576.0000000000002" GraphRef="b3f90" RelX="0.0" RelY="1.0" />
      <Point X="1572.1666666666667" Y="607.9666666666667" GraphRef="e987f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c6b9c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1235.0833333333333" Y="871.3333333333334" GraphRef="be821" RelX="-0.5" RelY="1.0" />
      <Point X="1239.4166666666667" Y="1363.3000000000002" GraphRef="d13d7" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c6bcb">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1220.0" Y="442.66666666666674" GraphRef="d5323" RelX="0.0" RelY="1.0" />
      <Point X="1197.4166666666667" Y="670.6333333333333" GraphRef="c380d" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c6c27">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1255.8333333333333" Y="871.3333333333334" GraphRef="be821" RelX="0.0" RelY="1.0" />
      <Point X="1257.8333333333333" Y="897.6333333333333" GraphRef="c4c25" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c7541">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1645.6666666666665" Y="376.0" GraphRef="e2386" RelX="0.0" RelY="1.0" />
      <Point X="1618.333333333333" Y="423.9666666666666" GraphRef="e7346" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c76e0">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="859.3083333333334" Y="174.3" GraphRef="cd01e" RelX="-0.5" RelY="-1.0" />
      <Point X="777.9833333333333" Y="108.0" GraphRef="d9175" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c8a25">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1447.9666666666667" Y="294.33333333333326" GraphRef="f0848" RelX="-1.0" RelY="0.0" />
      <Point X="1399.3333333333335" Y="267.33333333333326" GraphRef="c313f" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c8a9d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1434.6666666666665" Y="225.65" GraphRef="a9489" RelX="-1.0" RelY="0.0" />
      <Point X="1106.3333333333333" Y="189.4833333333333" GraphRef="ed51b" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c8eef">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1717.0" Y="754.65" GraphRef="a0a86" RelX="0.8806860551826995" RelY="0.0" />
      <Point X="1819.3" Y="804.3166666666668" GraphRef="bb747" RelX="-1.12112036336109" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c92bb">
    <BiopaxRef>c1b</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="880.3166666666667" Y="200.33333333333331" GraphRef="cd01e" RelX="0.0" RelY="1.0" />
      <Point X="827.7416666666667" Y="225.3" GraphRef="f0d73" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c9ac7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="225.98333333333332" Y="546.9666666666667" GraphRef="bbffd" RelX="0.0" RelY="-1.0" />
      <Point X="224.4833333333333" Y="532.0" GraphRef="da14e" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ca3ef">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1709.6666666666665" Y="246.91666666666663" GraphRef="a0466" RelX="-1.0" RelY="-0.5" />
      <Point X="804.0" Y="95.65" GraphRef="d9175" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ca6df">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="661.9916666666667" Y="545.9666666666667" GraphRef="a3c06" RelX="0.5" RelY="-1.0" />
      <Point X="662.5" Y="503.66666666666663" GraphRef="adf9b" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ca7fc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1285.3333333333335" Y="340.3333333333333" GraphRef="c1f0f" RelX="1.0" RelY="0.0" />
      <Point X="1351.6333333333332" Y="332.5" GraphRef="a73fd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ca9ad">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="ffcc00">
      <Point X="294.0" Y="1587.0" />
      <Point X="353.0" Y="1587.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cad54">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="779.6416666666667" Y="323.30000000000007" GraphRef="f4ca1" RelX="-0.5" RelY="-1.0" />
      <Point X="613.2416666666667" Y="167.66666666666666" GraphRef="faca8" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cb2bc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1352.725" Y="833.0" GraphRef="f4e2d" RelX="-0.5" RelY="1.0" />
      <Point X="1259.1666666666667" Y="944.9666666666667" GraphRef="e7a84" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cbcb6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="821.6583333333333" Y="349.33333333333337" GraphRef="f4ca1" RelX="0.5" RelY="1.0" />
      <Point X="1054.9833333333333" Y="603.0" GraphRef="a2eb5" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cc685">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1474.3166666666666" Y="304.9999999999999" GraphRef="f0848" RelX="0.0" RelY="1.0" />
      <Point X="1478.3166666666666" Y="384.33333333333337" GraphRef="e8405" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ccf06">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1057.9666666666667" Y="395.81666666666666" GraphRef="ea73a" RelX="-1.0" RelY="0.0" />
      <Point X="889.6666666666667" Y="441.6333333333333" GraphRef="ac9a8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cd370">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1625.8333333333333" Y="355.29999999999995" GraphRef="e2386" RelX="-0.5" RelY="-1.0" />
      <Point X="1153.9833333333331" Y="151.99999999999994" GraphRef="a69da" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ce7ce">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="289.48333333333335" Y="218.99999999999994" GraphRef="fb112" RelX="0.0" RelY="1.0" />
      <Point X="293.3166666666667" Y="248.3" GraphRef="b3cf1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cee63">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1198.0" Y="336.48333333333335" GraphRef="c40f2" RelX="1.0" RelY="0.0" />
      <Point X="1232.6333333333337" Y="340.3333333333333" GraphRef="c1f0f" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cef6d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1665.4999999999998" Y="355.29999999999995" GraphRef="e2386" RelX="0.5" RelY="-1.0" />
      <Point X="1752.9833333333333" Y="122.66666666666666" GraphRef="a2ea6" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cf347">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1809.3333333333333" Y="157.16666666666669" GraphRef="be91c" RelX="-1.0" RelY="0.0" />
      <Point X="1477.6666666666663" Y="213.3" GraphRef="a9489" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cf592">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="454.98333333333335" Y="368.6333333333333" GraphRef="b4d47" RelX="0.0" RelY="-1.0" />
      <Point X="454.65" Y="338.33333333333337" GraphRef="cb9d1" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cfd88">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="880.3166666666667" Y="174.3" GraphRef="cd01e" RelX="0.0" RelY="-1.0" />
      <Point X="894.65" Y="94.0" GraphRef="d4676" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d0c76">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1546.9666666666667" Y="755.9833333333333" GraphRef="f2c78" RelX="-1.0" RelY="0.0" />
      <Point X="1430.4833333333333" Y="814.6333333333333" GraphRef="a471f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d1352">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1211.8333333333335" Y="694.6666666666666" GraphRef="c380d" RelX="0.0" RelY="1.0" />
      <Point X="1205.166666666667" Y="1299.3" GraphRef="b040e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d3e32">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="663.9833333333333" Y="385.9666666666667" GraphRef="acb66" RelX="0.0" RelY="-1.0" />
      <Point X="616.9999999999999" Y="366.0" GraphRef="fb0f0" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d3e93">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="878.1666666666666" Y="608.0" GraphRef="ffb7c" RelX="0.0" RelY="1.0" />
      <Point X="878.1666666666666" Y="1301.3333333333335" GraphRef="a6b24" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d496d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="210.66666666666666" Y="495.3333333333333" />
      <Point X="202.8166666666667" Y="1316.3" GraphRef="b0c7d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d4a08">
    <BiopaxRef>a49</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="831.0" Y="454.81666666666666" GraphRef="ac9a8" RelX="-1.0" RelY="0.0" />
      <Point X="679.0" Y="493.15" GraphRef="adf9b" RelX="1.0" RelY="0.0" ArrowHead="mim-binding" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d5566">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1190.6666666666665" Y="140.9833333333333" GraphRef="a69da" RelX="1.0" RelY="0.0" />
      <Point X="1434.6666666666665" Y="225.65" GraphRef="a9489" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d5ad7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="669.0" Y="660.0" GraphRef="fa622" RelX="0.5" RelY="1.0" />
      <Point X="671.0" Y="1418.3333333333335" GraphRef="dcfb1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d5c73">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1059.8166666666666" Y="676.6666666666666" GraphRef="c0f26" RelX="0.0" RelY="1.0" />
      <Point X="1104.0" Y="711.9666666666667" GraphRef="b1edc" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d5d99">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="568.9666666666667" Y="156.16666666666666" GraphRef="faca8" RelX="-1.0" RelY="0.0" />
      <Point X="243.4833333333333" Y="424.9666666666667" GraphRef="fa621" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d5e6c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1722.6333333333332" Y="210.31666666666666" GraphRef="b24a2" RelX="-1.0" RelY="0.0" />
      <Point X="1491.9999999999995" Y="225.65" GraphRef="a9489" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d69dc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1660.6333333333332" Y="817.6666666666667" GraphRef="b83e1" RelX="-1.0701446733888644" RelY="0.0" />
      <Point X="1632.2884615384617" Y="838.6333333333333" GraphRef="bfd5d" RelX="0.3974358974358974" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d72c9">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1079.1416666666667" Y="345.3333333333333" GraphRef="c61c3" RelX="-0.5" RelY="1.0" />
      <Point X="1084.3166666666666" Y="385.6333333333333" GraphRef="ea73a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d799f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1665.4999999999998" Y="355.29999999999995" GraphRef="e2386" RelX="0.5" RelY="-1.0" />
      <Point X="1829.3333333333333" Y="169.33333333333337" GraphRef="be91c" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d7f90">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1600.6666666666667" Y="619.3166666666667" GraphRef="e987f" RelX="1.0" RelY="0.0" />
      <Point X="1678.3" Y="602.8166666666667" GraphRef="d72f6" RelX="-1.1366353543979504" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d8460">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="663.9833333333333" Y="385.9666666666667" GraphRef="acb66" RelX="0.0" RelY="-1.0" />
      <Point X="696.65" Y="362.0" GraphRef="caef5" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d85f9">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1852.8333333333337" Y="542.0" GraphRef="deae1" RelX="0.5" RelY="1.0" />
      <Point X="1854.3333333333335" Y="1315.6666666666667" GraphRef="fe3fb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d873a">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1140.8333333333333" Y="555.6666666666666" GraphRef="e05b1" RelX="0.0" RelY="1.0" />
      <Point X="1489.725" Y="813.9666666666667" GraphRef="c65a6" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d87db">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="613.2416666666667" Y="167.66666666666666" GraphRef="faca8" RelX="0.5" RelY="1.0" />
      <Point X="1266.9666666666667" Y="469.48333333333335" GraphRef="ed2ee" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d8e6d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="889.6666666666667" Y="468.0" GraphRef="ac9a8" RelX="0.0" RelY="1.0" />
      <Point X="894.3166666666668" Y="1243.6333333333332" GraphRef="b09c3" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d98c7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1561.4166666666667" Y="576.0000000000002" GraphRef="b3f90" RelX="-0.5" RelY="1.0" />
      <Point X="1557.5" Y="1388.9666666666667" GraphRef="b28eb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d9bcf">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1261.5833333333333" Y="556.0" GraphRef="f5384" RelX="0.5" RelY="1.0" />
      <Point X="1262.3333333333335" Y="1442.0" GraphRef="c37b8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="da391">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1224.0" Y="244.65" GraphRef="e6c26" RelX="1.0" RelY="0.0" />
      <Point X="1298.975" Y="200.66666666666663" GraphRef="fca55" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="db5f2">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="294.0" Y="1619.0" />
      <Point X="353.0" Y="1619.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dbb3b">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="383.66666666666663" Y="717.9999999999999" GraphRef="a3de1" RelX="1.0" RelY="0.5" />
      <Point X="458.6666666666667" Y="568.3333333333334" GraphRef="cc574" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dc1b5">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="415.9666666666667" Y="155.9833333333333" GraphRef="a1f2f" RelX="-1.0" RelY="0.0" />
      <Point X="352.0" Y="164.31666666666666" GraphRef="bc28c" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dd94c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1638.1666666666663" Y="444.66666666666663" GraphRef="e7346" RelX="0.5" RelY="1.0" />
      <Point X="1690.725" Y="593.9666666666667" GraphRef="d72f6" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="df76d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1568.65" Y="817.6666666666667" GraphRef="e4e7f" RelX="0.0" RelY="1.0" />
      <Point X="1566.65" Y="1270.2999999999997" GraphRef="eca8d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="df799">
    <BiopaxRef>e80</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="948.3333333333335" Y="454.81666666666666" GraphRef="ac9a8" RelX="1.0" RelY="0.0" />
      <Point X="1447.9666666666667" Y="336.5" GraphRef="b624d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="df925">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1717.3333333333333" Y="602.8166666666667" GraphRef="d72f6" RelX="0.8633646456020495" RelY="0.0" />
      <Point X="1818.3" Y="685.3166666666668" GraphRef="ddc41" RelX="-1.12112036336109" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dfac6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1477.4833333333333" Y="443.0" GraphRef="ac422" RelX="0.0" RelY="-1.0" />
      <Point X="1478.3166666666666" Y="408.66666666666663" GraphRef="e8405" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dfbf7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="901.325" Y="174.3" GraphRef="cd01e" RelX="0.5" RelY="-1.0" />
      <Point X="994.65" Y="115.33333333333334" GraphRef="c78fe" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e000c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1078.9166666666667" Y="478.0" GraphRef="bd36d" RelX="-0.5" RelY="-1.0" />
      <Point X="1071.0749999999998" Y="458.0" GraphRef="da359" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e0030">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="663.65" Y="423.6333333333333" GraphRef="f453a" RelX="0.0" RelY="-1.0" />
      <Point X="663.9833333333333" Y="400.0" GraphRef="acb66" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e03c6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1156.9666666666667" Y="611.1666666666666" GraphRef="cfa4d" RelX="-1.0" RelY="0.0" />
      <Point X="1061.0" Y="609.5" GraphRef="a2eb5" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e049e">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1153.4750000000001" Y="399.3333333333333" GraphRef="c0da9" RelX="-0.5" RelY="1.0" />
      <Point X="916.4833333333333" Y="538.3333333333334" GraphRef="dfeff" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e0656">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="619.975" Y="572.0" GraphRef="a3c06" RelX="-0.5" RelY="1.0" />
      <Point X="619.3166666666667" Y="1269.3" GraphRef="a849a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e06a7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1410.0" Y="332.5" GraphRef="a73fd" RelX="1.0" RelY="0.0" />
      <Point X="1447.9666666666667" Y="336.5" GraphRef="b624d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e0a0b">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="448.48333333333335" Y="505.0" GraphRef="ad3de" RelX="0.0" RelY="1.0" />
      <Point X="438.48333333333335" Y="1355.3" GraphRef="c6123" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e0bce">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="662.5" Y="482.6333333333333" GraphRef="adf9b" RelX="0.0" RelY="-1.0" />
      <Point X="663.65" Y="449.66666666666663" GraphRef="f453a" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e0c94">
    <BiopaxRef>a89</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1054.9833333333333" Y="616.0" GraphRef="a2eb5" RelX="0.0" RelY="1.0" />
      <Point X="1059.8166666666666" Y="647.6666666666666" GraphRef="c0f26" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e1042">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1039.0583333333334" Y="676.6666666666666" GraphRef="c0f26" RelX="-0.5" RelY="1.0" />
      <Point X="1001.0" Y="707.9666666666667" GraphRef="a8206" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e14e1">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
      <Point X="296.0" Y="1651.0" />
      <Point X="355.0" Y="1651.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e1f14">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="454.98333333333335" Y="394.66666666666663" GraphRef="b4d47" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
      <Point X="454.3166666666667" Y="431.6333333333333" GraphRef="d0cb7" RelX="0.0" RelY="-1.0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e23b3">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="444.1666666666667" Y="545.3000000000001" GraphRef="cc574" RelX="-0.5" RelY="-1.0" />
      <Point X="445.48333333333335" Y="229.0" GraphRef="e0731" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e2f07">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="415.9666666666667" Y="162.49166666666662" GraphRef="a1f2f" RelX="-1.0" RelY="0.5" />
      <Point X="220.33333333333334" Y="624.9666666666667" GraphRef="b0d0c" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e33e2">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1140.8333333333333" Y="555.6666666666666" GraphRef="e05b1" RelX="0.0" RelY="1.0" />
      <Point X="1687.725" Y="645.9666666666667" GraphRef="f2d8d" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e3e11">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1546.9666666666667" Y="755.9833333333333" GraphRef="f2c78" RelX="-1.0" RelY="0.0" />
      <Point X="1372.2416666666668" Y="815.3" GraphRef="f4e2d" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e41b5">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1675.3" Y="654.8166666666667" GraphRef="f2d8d" RelX="-1.1366353543979504" RelY="0.0" />
      <Point X="1589.0" Y="682.6500000000001" GraphRef="adc69" RelX="0.8788796366389099" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e420d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1430.4833333333333" Y="832.3333333333334" GraphRef="a471f" RelX="0.0" RelY="1.0" />
      <Point X="1431.333333333333" Y="877.6333333333334" GraphRef="bedf5" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e4b02">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1733.6666666666665" Y="327.5833333333333" GraphRef="e3b77" RelX="-1.0" RelY="-0.5" />
      <Point X="1491.9999999999995" Y="225.65" GraphRef="a9489" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e60f5">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="803.6666666666669" Y="528.0" GraphRef="dd89a" RelX="0.5" RelY="1.0" />
      <Point X="800.6666666666667" Y="1374.3000000000002" GraphRef="f1623" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e61d6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1591.0" Y="755.9833333333333" GraphRef="f2c78" RelX="1.0" RelY="0.0" />
      <Point X="1674.9666666666667" Y="754.65" GraphRef="a0a86" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e66ca">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="472.5" Y="647.0" GraphRef="a0ad8" RelX="0.0" RelY="1.0" />
      <Point X="469.5" Y="1260.3" GraphRef="fea32" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e6850">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1171.65" Y="348.6666666666667" GraphRef="c40f2" RelX="0.0" RelY="1.0" />
      <Point X="1166.65" Y="378.96666666666664" GraphRef="c0da9" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e7437">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="696.65" Y="335.9666666666667" GraphRef="caef5" RelX="0.0" RelY="-1.0" />
      <Point X="800.65" Y="349.33333333333337" GraphRef="f4ca1" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e854e">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="385.9666666666667" Y="491.98333333333335" GraphRef="ad3de" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
      <Point X="286.66666666666663" Y="491.98333333333335" GraphRef="b428f" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e93ca">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1683.475" Y="764.0" GraphRef="a0a86" RelX="-0.6193139448173005" RelY="1.0" />
      <Point X="1588.0" Y="806.9833333333333" GraphRef="e4e7f" RelX="0.8788796366389099" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e94cc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1359.8083333333336" Y="277.9999999999999" GraphRef="c313f" RelX="-0.5" RelY="1.0" />
      <Point X="1358.4750000000001" Y="1404.3333333333335" GraphRef="f3a68" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e9b16">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="321.2416666666667" Y="177.33333333333331" GraphRef="bc28c" RelX="0.5" RelY="1.0" />
      <Point X="318.9083333333333" Y="1461.3" GraphRef="bd16d" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ea546">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1431.333333333333" Y="899.0000000000002" GraphRef="bedf5" RelX="0.0" RelY="1.0" />
      <Point X="1435.0" Y="1293.9666666666667" GraphRef="a1fea" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eac34">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="800.65" Y="349.33333333333337" GraphRef="f4ca1" RelX="0.0" RelY="1.0" />
      <Point X="782.65" Y="1318.6333333333334" GraphRef="aedad" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eaf1f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1247.6416666666667" Y="624.0" GraphRef="b00f5" RelX="-0.5" RelY="1.0" />
      <Point X="1252.9833333333336" Y="1404.3333333333333" GraphRef="d9ca5" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eb684">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1762.0" Y="346.3333333333333" GraphRef="e3b77" RelX="0.0" RelY="1.0" />
      <Point X="1761.0" Y="1463.3333333333333" GraphRef="afb23" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ec1b6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1320.3000000000002" Y="300.0" GraphRef="d0dc2" RelX="-1.0" RelY="0.0" />
      <Point X="1091.3333333333335" Y="279.65" GraphRef="da207" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ec3d7">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1773.666666666667" Y="582.5833333333334" GraphRef="e7832" RelX="-1.0941176470588236" RelY="-0.5" />
      <Point X="1717.3333333333333" Y="602.8166666666667" GraphRef="d72f6" RelX="0.8633646456020495" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ec9ac">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="922.3333333333334" Y="193.825" GraphRef="cd01e" RelX="1.0" RelY="0.5" />
      <Point X="1198.3333333333335" Y="427.1666666666667" GraphRef="d5323" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ed354">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="508.2416666666667" Y="168.99999999999994" GraphRef="a1f2f" RelX="0.5" RelY="1.0" />
      <Point X="503.48333333333335" Y="1424.3" GraphRef="fce8a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="eda03">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="897.0" Y="191.0" />
      <Point X="906.3166666666667" Y="1436.3" GraphRef="f6e52" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ee405">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1802.0000000000002" Y="601.3333333333334" GraphRef="e7832" RelX="-0.09411764705882353" RelY="1.0" />
      <Point X="1717.6583333333333" Y="806.0" GraphRef="b83e1" RelX="0.42985532661113546" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ee7bf">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="983.3333333333334" Y="341.3166666666667" GraphRef="cfbd0" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Point X="1065.9666666666667" Y="335.15" GraphRef="c61c3" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ef3f6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1506.4916666666666" Y="408.66666666666663" GraphRef="e8405" RelX="0.5" RelY="1.0" />
      <Point X="1509.65" Y="1458.3333333333335" GraphRef="d8a07" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ef497">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1557.9166666666667" Y="630.6666666666667" GraphRef="e987f" RelX="-0.5" RelY="1.0" />
      <Point X="1679.6416666666667" Y="806.0" GraphRef="b83e1" RelX="-0.5701446733888645" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ef671">
    <BiopaxRef>f96</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1546.9666666666667" Y="755.9833333333333" GraphRef="f2c78" RelX="-1.0" RelY="0.0" />
      <Point X="1311.15" Y="795.3" GraphRef="ea891" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ef69f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1158.4750000000001" Y="324.3" GraphRef="c40f2" RelX="-0.5" RelY="-1.0" />
      <Point X="1066.65" Y="292.66666666666663" GraphRef="da207" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ef89f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1124.0833333333333" Y="555.6666666666666" GraphRef="e05b1" RelX="-0.5" RelY="1.0" />
      <Point X="1420.725" Y="814.6333333333333" GraphRef="a471f" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ef942">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1738.0" Y="265.66666666666663" GraphRef="a0466" RelX="0.0" RelY="1.0" />
      <Point X="1717.0" Y="1386.0" GraphRef="f703c" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f2733">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1140.8333333333333" Y="530.6333333333333" GraphRef="e05b1" RelX="0.0" RelY="-1.0" />
      <Point X="1106.7500000000002" Y="495.0" GraphRef="bd36d" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f274e">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="235.98333333333332" Y="569.9833333333333" />
      <Point X="800.65" Y="349.33333333333337" GraphRef="f4ca1" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f2763">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1589.0" Y="682.6500000000001" GraphRef="adc69" RelX="0.8788796366389099" RelY="0.0" />
      <Point X="1654.6333333333337" Y="699.3166666666667" GraphRef="a7c7a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f30ae">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="950.0" Y="546.5833333333334" GraphRef="dfeff" RelX="1.0" RelY="-0.5" />
      <Point X="1469.9666666666667" Y="449.5" GraphRef="ac422" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f3fe6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1091.3333333333335" Y="273.14166666666665" GraphRef="da207" RelX="1.0" RelY="-0.5" />
      <Point X="1346.6333333333337" Y="267.33333333333326" GraphRef="c313f" RelX="-1.0" RelY="0.0" ArrowHead="mim-binding" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f46fb">
    <BiopaxRef>ce8</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1274.4833333333333" Y="476.0" GraphRef="ed2ee" RelX="0.0" RelY="1.0" />
      <Point X="1345.6666666666667" Y="508.33333333333337" GraphRef="d6c91" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f4d6c">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="844.0" Y="260.65" GraphRef="c84b1" RelX="1.0" RelY="0.0" />
      <Point X="895.6333333333334" Y="242.81666666666666" GraphRef="fec4e" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f4d70">
    <BiopaxRef>bc2</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="831.0" Y="448.225" GraphRef="ac9a8" RelX="-1.0" RelY="-0.5" />
      <Point X="672.0" Y="392.98333333333335" GraphRef="acb66" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f5436">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1109.3333333333333" Y="340.0" ArrowHead="Arrow" />
      <Point X="1145.3000000000002" Y="336.48333333333335" GraphRef="c40f2" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f5cbc">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="198.33333333333334" Y="649.0" GraphRef="b0d0c" RelX="0.0" RelY="1.0" />
      <Point X="187.0" Y="1401.6333333333334" GraphRef="f26d4" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f630b">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1599.6666666666667" Y="558.5000000000001" GraphRef="b3f90" RelX="1.0" RelY="-0.5" />
      <Point X="1664.6666666666667" Y="491.22499999999997" GraphRef="ad8ba" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f63d4">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1135.6416666666664" Y="151.99999999999994" GraphRef="a69da" RelX="-0.5" RelY="1.0" />
      <Point X="1180.9833333333333" Y="185.96666666666664" GraphRef="e63a2" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f6d51">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="611.0" Y="660.0" GraphRef="fa622" RelX="-0.5" RelY="1.0" />
      <Point X="587.3333333333334" Y="740.6666666666666" GraphRef="b8279" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f6ec6">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="445.48333333333335" Y="216.0" GraphRef="e0731" RelX="0.0" RelY="-1.0" />
      <Point X="446.725" Y="168.99999999999994" GraphRef="a1f2f" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f7724">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="786.0" Y="646.15" GraphRef="e2cdf" RelX="-1.0" RelY="0.0" />
      <Point X="670.75" Y="503.66666666666663" GraphRef="adf9b" RelX="0.5" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f79e4">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1620.1666666666667" Y="858.6666666666666" GraphRef="bfd5d" RelX="0.0" RelY="1.0" />
      <Point X="1624.1666666666665" Y="1289.9666666666667" GraphRef="e0aa6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f7a96">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1477.3166666666666" Y="480.33333333333337" GraphRef="ae9b5" RelX="0.0" RelY="-1.0" />
      <Point X="1477.4833333333333" Y="456.0" GraphRef="ac422" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f8888">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1740.3333333333333" Y="540.2249999999999" GraphRef="f67de" RelX="1.0" RelY="-0.5" />
      <Point X="1790.5000000000002" Y="576.3333333333334" GraphRef="e7832" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f8cb0">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="cccc00">
      <Point X="1598.4999999999998" Y="423.9666666666666" GraphRef="e7346" RelX="-0.5" RelY="-1.0" />
      <Point X="1463.333333333333" Y="238.0" GraphRef="a9489" RelX="0.0" RelY="1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="f9160">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="736.6666666666667" Y="516.15" GraphRef="dd89a" RelX="-1.0" RelY="0.0" />
      <Point X="497.0" Y="375.14166666666665" GraphRef="b4d47" RelX="1.0" RelY="-0.5" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fa7f0">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="844.0" Y="260.65" GraphRef="c84b1" RelX="1.0" RelY="0.0" />
      <Point X="1050.5583333333334" Y="442.29999999999995" GraphRef="da359" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fa915">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1180.9833333333333" Y="211.99999999999994" GraphRef="e63a2" RelX="0.0" RelY="1.0" />
      <Point X="1198.15" Y="233.3" GraphRef="e6c26" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fba92">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="1709.6666666666665" Y="259.41666666666663" GraphRef="a0466" RelX="-1.0" RelY="0.5" />
      <Point X="1491.9999999999995" Y="225.65" GraphRef="a9489" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fc49f">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1499.4833333333333" Y="831.6666666666667" GraphRef="c65a6" RelX="0.0" RelY="1.0" />
      <Point X="1500.65" Y="872.3" GraphRef="ef888" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fc84a">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1663.3333333333333" Y="540.2249999999999" GraphRef="f67de" RelX="-1.0" RelY="-0.5" />
      <Point X="1600.6666666666667" Y="619.3166666666667" GraphRef="e987f" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fcb1a">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="293.3166666666667" Y="269.6666666666667" GraphRef="b3cf1" RelX="0.0" RelY="1.0" />
      <Point X="285.98333333333335" Y="1354.9666666666667" GraphRef="b0460" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fcc44">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1739.3333333333333" Y="817.6666666666667" GraphRef="b83e1" RelX="1.0" RelY="0.0" />
      <Point X="1782.6666666666667" Y="848.0" GraphRef="daa47" RelX="-0.09411764705882353" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fcd65">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccc00">
      <Point X="294.0" Y="1555.0" />
      <Point X="353.0" Y="1555.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fd869">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1333.4750000000001" Y="310.66666666666663" GraphRef="d0dc2" RelX="-0.5" RelY="1.0" />
      <Point X="1341.3166666666666" Y="1462.3333333333335" GraphRef="e8ddb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fda78">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1546.9666666666667" Y="755.9833333333333" GraphRef="f2c78" RelX="-1.0" RelY="0.0" />
      <Point X="1499.4833333333333" Y="813.9666666666667" GraphRef="c65a6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fe802">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="1317.3166666666666" Y="200.66666666666663" GraphRef="fca55" RelX="0.0" RelY="1.0" />
      <Point X="1311.3166666666666" Y="1318.0" GraphRef="edea8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ff95d">
    <Graphics ZOrder="12288" LineThickness="1.0" Color="cccccc">
      <Point X="916.4833333333333" Y="571.3333333333334" GraphRef="dfeff" RelX="0.0" RelY="1.0" />
      <Point X="913.4833333333333" Y="1352.3333333333333" GraphRef="e07b6" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Label TextLabel="B" GraphId="a29f9">
    <Graphics CenterX="856.5" CenterY="212.0" Width="17.0" Height="14.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Interconversion" GraphId="a7a59">
    <Graphics CenterX="802.8333333333334" CenterY="616.0" Width="95.66666666666667" Height="36.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="T" GraphId="ad486">
    <Graphics CenterX="598.0" CenterY="309.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Transport" GraphId="af07e">
    <Graphics CenterX="591.0" CenterY="1660.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="" GraphId="b03d3" GroupRef="f5de1">
    <Graphics CenterX="143.5" CenterY="1678.5" Width="21.0" Height="17.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
  </Label>
  <Label TextLabel="Formation &#xA;of Heme" GraphId="b32b6" GroupRef="ba446">
    <Graphics CenterX="1028.0" CenterY="548.0" Width="78.0" Height="30.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="B" GraphId="b3b3b">
    <Graphics CenterX="888.0" CenterY="124.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="b4d8f">
    <Graphics CenterX="752.0" CenterY="476.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="T" GraphId="b51a4">
    <Graphics CenterX="1730.0" CenterY="187.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="b5214">
    <Graphics CenterX="1633.0" CenterY="249.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Binding" GraphId="b7222">
    <Graphics CenterX="591.0" CenterY="1562.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="B" GraphId="bbb25">
    <Graphics CenterX="1281.0" CenterY="766.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="bc2de">
    <Graphics CenterX="1423.0" CenterY="280.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="TT" GraphId="bccdf">
    <Graphics CenterX="409.0" CenterY="635.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccccc" />
  </Label>
  <Label TextLabel="Competition" GraphId="bd08a">
    <Graphics CenterX="598.0" CenterY="1690.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="CN" GraphId="bd720">
    <Graphics CenterX="347.0" CenterY="677.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ffcc00" />
  </Label>
  <Label TextLabel="IE" GraphId="c1b84">
    <Graphics CenterX="1653.0" CenterY="481.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Transformation" GraphId="c52eb">
    <Graphics CenterX="597.0" CenterY="1592.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="B" GraphId="c55e0">
    <Graphics CenterX="1614.0" CenterY="276.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="c818c">
    <Graphics CenterX="1412.0" CenterY="577.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="cb737">
    <Graphics CenterX="1189.0" CenterY="307.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="cd062">
    <Graphics CenterX="1372.0" CenterY="766.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="ce37f">
    <Graphics CenterX="738.0" CenterY="413.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="T" GraphId="cfc25">
    <Graphics CenterX="1633.0" CenterY="396.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Unspecified interaction" GraphId="d0294">
    <Graphics CenterX="418.5" CenterY="1649.0" Width="113.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="B" GraphId="d17ea">
    <Graphics CenterX="1658.0" CenterY="214.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Negative effect" GraphId="d1962">
    <Graphics CenterX="400.0" CenterY="1585.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="B" GraphId="d2736">
    <Graphics CenterX="1122.0" CenterY="313.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="d500e">
    <Graphics CenterX="1212.0" CenterY="338.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Synthesis of choline" GraphId="d7b57" GroupRef="c15b7">
    <Graphics CenterX="554.0" CenterY="406.1666666666667" Width="133.33333333333334" Height="37.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="B" GraphId="d9122">
    <Graphics CenterX="265.0" CenterY="636.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Unspecified effect" GraphId="dbf8f">
    <Graphics CenterX="407.5" CenterY="1616.0" Width="95.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="Conversion" GraphId="dbfe1" GroupRef="c0a2e">
    <Graphics CenterX="1406.0" CenterY="458.0" Width="78.0" Height="30.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="B" GraphId="deb9d">
    <Graphics CenterX="1126.0" CenterY="514.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Nucleotide biosynthesis" GraphId="dffcd" GroupRef="de709">
    <Graphics CenterX="590.6666666666666" CenterY="759.3333333333334" Width="156.0" Height="39.333333333333336" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="B" GraphId="e2131">
    <Graphics CenterX="1169.0" CenterY="359.5" Width="16.0" Height="13.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Influence on expression" GraphId="e217e">
    <Graphics CenterX="617.0" CenterY="1626.0" Width="132.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="B" GraphId="e2b95">
    <Graphics CenterX="806.0" CenterY="130.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Positive effect" GraphId="e3cd1">
    <Graphics CenterX="400.0" CenterY="1553.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="" GraphId="e9b3e">
    <Graphics CenterX="392.97427416391037" CenterY="1652.3717383314959" Width="612.0" Height="239.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="00ffcc" />
  </Label>
  <Label TextLabel="B" GraphId="ea0a2">
    <Graphics CenterX="572.0" CenterY="492.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="ea98a">
    <Graphics CenterX="1081.0" CenterY="361.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="INTRACELULAR" GraphId="eace5">
    <Graphics CenterX="148.16666666666666" CenterY="1159.3333333333333" Width="223.66666666666666" Height="51.333333333333336" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="26" Valign="Middle" Color="993300" />
  </Label>
  <Label TextLabel="T" GraphId="ebd16">
    <Graphics CenterX="1625.0" CenterY="463.0" Width="16.0" Height="14.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ffcc00" />
  </Label>
  <Label TextLabel="B" GraphId="ec7d2">
    <Graphics CenterX="1411.0" CenterY="753.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="T" GraphId="ed32b">
    <Graphics CenterX="1312.0" CenterY="222.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Main functions" GraphId="edd53">
    <Graphics CenterX="298.0" CenterY="1721.3333333333333" Width="156.0" Height="39.333333333333336" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="13" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="T" GraphId="ee15d">
    <Graphics CenterX="1807.0" CenterY="199.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="ef4f5">
    <Graphics CenterX="946.0" CenterY="211.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="f0868">
    <Graphics CenterX="1263.0" CenterY="379.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="METABOLITE" GraphId="f1293">
    <Graphics CenterX="176.5" CenterY="1598.0" Width="83.0" Height="22.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
  </Label>
  <Label TextLabel="PLASMA" GraphId="f3152">
    <Graphics CenterX="107.16666666666667" CenterY="1467.3333333333333" Width="121.66666666666667" Height="51.333333333333336" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="26" Valign="Middle" Color="993300" />
  </Label>
  <Label TextLabel="B" GraphId="f6080">
    <Graphics CenterX="1425.0" CenterY="600.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="f62db">
    <Graphics CenterX="793.0" CenterY="180.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Generic enzyme" GraphId="f8016">
    <Graphics CenterX="175.5" CenterY="1639.0" Width="83.0" Height="22.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ff3300" />
  </Label>
  <Label TextLabel="B" GraphId="f8e19">
    <Graphics CenterX="1668.0" CenterY="239.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="Formation of &#xA;methionine&#xA;" GraphId="f8e8c" GroupRef="d0b0b">
    <Graphics CenterX="351.0" CenterY="552.1666666666666" Width="79.33333333333333" Height="24.333333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="cc00cc" />
  </Label>
  <Label TextLabel="Reaction" GraphId="faa85" GroupRef="f5de1">
    <Graphics CenterX="190.0" CenterY="1679.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" />
  </Label>
  <Label TextLabel="B" GraphId="fcaf0">
    <Graphics CenterX="1407.0" CenterY="297.5" Width="16.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="B" GraphId="fd022">
    <Graphics CenterX="967.0" CenterY="132.5" Width="16.0" Height="17.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="cccc00" />
  </Label>
  <Label TextLabel="T" GraphId="fd602">
    <Graphics CenterX="1407.0" CenterY="433.5" Width="14.0" Height="15.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ffcc00" />
  </Label>
  <Shape GraphId="a07b2" GroupRef="ba446">
    <Graphics CenterX="1027.3333333333333" CenterY="546.6666666666666" Width="80.0" Height="38.666666666666664" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.0" />
  </Shape>
  <Shape GraphId="a2eb5">
    <Graphics CenterX="1054.9833333333333" CenterY="609.5" Width="12.033333333333333" Height="13.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="ac422">
    <Graphics CenterX="1477.4833333333333" CenterY="449.5" Width="15.033333333333333" Height="13.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="acb66">
    <Graphics CenterX="663.9833333333333" CenterY="392.98333333333335" Width="16.033333333333335" Height="14.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="b624d">
    <Graphics CenterX="1454.9833333333333" CenterY="336.5" Width="14.033333333333333" Height="11.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="b8279" GroupRef="de709">
    <Graphics CenterX="587.3333333333334" CenterY="760.6666666666666" Width="154.66666666666666" Height="40.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.0" />
  </Shape>
  <Shape GraphId="b9010" GroupRef="c0a2e">
    <Graphics CenterX="1405.3333333333333" CenterY="462.0" Width="80.0" Height="38.666666666666664" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.0" />
  </Shape>
  <Shape GraphId="bd824">
    <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" />
    <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
    <Graphics CenterX="998.0405982905984" CenterY="1358.7243589743593" Width="1986.8247863247866" Height="321.86752136752096" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
  </Shape>
  <Shape GraphId="c36e1" GroupRef="c15b7">
    <Graphics CenterX="554.6666666666666" CenterY="405.3333333333333" Width="118.66666666666667" Height="41.333333333333336" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.00826427465965116" />
  </Shape>
  <Shape GraphId="c4851">
    <Graphics CenterX="804.8333333333334" CenterY="617.3333333333334" Width="109.66666666666667" Height="42.666666666666664" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.0" />
  </Shape>
  <Shape GraphId="cb8e1">
    <Graphics CenterX="178.33333333333334" CenterY="1723.6666666666667" Width="106.0" Height="28.666666666666668" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.0" />
  </Shape>
  <Shape GraphId="d661a">
    <Graphics CenterX="828.0956707649402" CenterY="614.2373932706329" Width="81.5563947361317" Height="77.45430069872585" ZOrder="16384" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Arc" Color="cccccc" Rotation="2.3287014193401827" />
  </Shape>
  <Shape GraphId="da14e">
    <Graphics CenterX="224.48333333333332" CenterY="525.9833333333333" Width="13.033333333333333" Height="12.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="e0731">
    <Graphics CenterX="445.48333333333335" CenterY="222.5" Width="13.033333333333333" Height="13.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="eb572" GroupRef="d0b0b">
    <Graphics CenterX="350.6666666666667" CenterY="554.0" Width="112.0" Height="36.666666666666664" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Color="cc00cc" Rotation="0.0" />
  </Shape>
  <Shape GraphId="ed2ee">
    <Graphics CenterX="1274.4833333333333" CenterY="469.48333333333335" Width="15.033333333333333" Height="13.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="fa621">
    <Graphics CenterX="243.48333333333332" CenterY="430.98333333333335" Width="13.033333333333333" Height="12.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Shape GraphId="fb112">
    <Graphics CenterX="289.48333333333335" CenterY="212.98333333333332" Width="13.033333333333333" Height="12.033333333333333" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
  </Shape>
  <Group GroupId="de709" GraphId="bd38b" />
  <Group GroupId="d0b0b" GraphId="c8398" />
  <Group GroupId="c0a2e" GraphId="f98eb" />
  <Group GroupId="f5de1" GraphId="fa58b" />
  <Group GroupId="ba446" GraphId="fbe07" />
  <Group GroupId="c15b7" GraphId="fdddd" />
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bc2">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">840498</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cystathionine beta-synthase deficiency: a qualitative abnormality of the deficient enzyme modified by vitamin B6 therapy.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pediatr Res. </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1977</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Longhi RC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fleisher LD</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tallan HH</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gaull GE.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f96">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandin and Leukotriene Metabolism</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ingenuity software</bp:SOURCE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://analysis.ingenuity.com/</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ce8">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15104204</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isoprostanes: novel bioactive products of lipid peroxidation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Free Radic Res.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Basu S.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c1b">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18598592</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A network biology model of micronutrient related health</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Br J Nutr</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ben van Ommen</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Susan Fairweather-Tait</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Andreas Freidig</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alwine Kardinaal</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Augustin Scalbert</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suzan Wopereis</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cd4">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16047261</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. </bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Semin Vasc Med</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fowler B.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cc4">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8968737</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. </bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hum Mol Genet. </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leclerc D</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Campeau E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goyette P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adjalla CE</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Christensen B</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ross M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eydoux P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rosenblatt DS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rozen R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gravel RA.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dc8">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16011463</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vitamin E, oxidative stress, and inflammation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Annu Rev Nutr.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Singh U</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Devaraj S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jialal I.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ebb">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14726604</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nitric oxide and superoxide in inflammation and immune regulation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Physiol Pharmacol.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2003</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guzik TJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Korbut R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adamek-Guzik T.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bbd">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6300970</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1982</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Denis D</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Charleson S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rackham A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jones TR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ford-Hutchinson AW</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lord A, Cirino M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Girard Y</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Larue M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rokach J.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a58">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18409172</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IUBMB Life.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Petersen Shay K</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moreau RF</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Smith EJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hagen TM.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a21">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16962588</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FEBS Lett.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lu C</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Qiu F</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhou H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peng Yp</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hao W</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu J</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yuan J</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Qiang B</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu C</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peng X.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf3">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10448523</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homocysteine metabolism.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Annu Rev Nutr</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Selhub J.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dab">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6295699</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vitamin B12 binders (transcobalamins) in serum.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Crit Rev Clin Lab Sci. </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1982</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernandes-Costa F: Metz J.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e80">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vitamin B 6</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Linus Paulin institute</bp:SOURCE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB6/</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca8">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10444342</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. </bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular genetics and metabolism</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b89">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">978-0-309-06411-8</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Washington D.C.: National Academies Press</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1998</bp:YEAR>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cbd">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11731805</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Struct Biol. </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bandarian V</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pattridge KA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lennon BW</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huddler DP</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matthews RG</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ludwig ML.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c1e">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11929995</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proc Natl Acad Sci U S A. </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kryukov GV</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kumar RA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Koc A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sun Z</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gladyshev VN.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b83">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Folic acid</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Linus Pauling Institute</bp:SOURCE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://lpi.oregonstate.edu/infocenter/vitamins/fa/</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ec3">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WP28</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WikiPathways</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Selenoproteins</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://www.wikipathways.org/index.php/Pathway:Homo_sapiens:Selenoproteins</bp:SOURCE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WikiPathways</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a49">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.1021/bi981808n</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOI</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine β-Synthase</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochemistry 38(9)</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vladimir Kery</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Loelle Poneleit</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jeffrey D. Meyer</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mark C. Manning</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jan P. Kraus</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f1b">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10448523</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homocysteine metabolism.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Annu Rev Nutr. </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1999</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Selhub J.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f15">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8846925</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Free radicals, uric acid, and human disease.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Free Radic Biol Med.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proctor PH.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ed9">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18466421</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of urate and xanthine oxidase inhibitors in cardiovascular disease.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cardiovasc Ther.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">George J</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Struthers AD.</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a89">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandin and Leukotriene Metabolism</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ingenuity software</bp:SOURCE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://analysis.ingenuity.com/pa/</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e10">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1184739</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Transcobalamins I and II as natural transport proteins of vitamin B12. </bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Journal of clinical investigation </bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1975</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hall CA</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ff2">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arachidonic Acid Metabolism</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ingenuity sofware</bp:SOURCE>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://analysis.ingenuity.com/</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pathway of folate cycle/metabolism</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000140</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a62">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8534261</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The isoprostanes. Current knowledge and directions for future research.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem Pharmacol.</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1996</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morrow JD</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roberts LJ 2nd.</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>

