<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="p38 Mapk signaling pathway" Data-Source="WikiPathways" Version="WP350_r123113" Author="[S.Burel, MaintBot, Khanspers, Ddigles, AlexanderPico, Mkutmon, DeSl, Eweitz, Egonw]" Last-Modified="20220704070347" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.</Comment>
  <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP400_r95117 WP400 (r95117)] with a 100.0% conversion rate.</Comment>
  <BiopaxRef>a09</BiopaxRef>
  <BiopaxRef>d07</BiopaxRef>
  <BiopaxRef>c22</BiopaxRef>
  <BiopaxRef>a36</BiopaxRef>
  <BiopaxRef>bf697</BiopaxRef>
  <BiopaxRef>c41</BiopaxRef>
  <BiopaxRef>bb5</BiopaxRef>
  <BiopaxRef>f85</BiopaxRef>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9261</Comment>
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  <DataNode TextLabel="Grb2" GraphId="a30" Type="GeneProduct" GroupRef="b85a4">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2885</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2" />
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  <DataNode TextLabel="Traf2" GraphId="a3c" Type="GeneProduct" GroupRef="e6a4d">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7186</Comment>
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  <DataNode TextLabel="Gm42878" GraphId="a3f" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8550</Comment>
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  <DataNode TextLabel="Shc1" GraphId="aa6" Type="GeneProduct" GroupRef="b85a4">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6464</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4293</Comment>
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  <DataNode TextLabel="Rac1" GraphId="b32" Type="GeneProduct">
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  <DataNode TextLabel="Tgfbr1" GraphId="b42" Type="GeneProduct">
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  <DataNode TextLabel="Mef2d" GraphId="b4f" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4209</Comment>
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  <DataNode TextLabel="Stat1" GraphId="b96" Type="GeneProduct">
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1385</Comment>
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  <DataNode TextLabel="Map3k5" GraphId="c2f" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4217</Comment>
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  <DataNode TextLabel="Mknk1" GraphId="c44" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8569</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6885</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9252</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4149</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAX | MYC associated factor X" />
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  <DataNode TextLabel="Mapk14" GraphId="cd6" Type="GeneProduct">
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:998</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3150</Comment>
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