<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Sphingolipid metabolism (integrated pathway)" Data-Source="WikiPathways" Version="WP4690_r139824" Author="[DeSl, MaintBot, Eweitz, Conroy lipids, Khanspers, Egonw, Ddigles]" Last-Modified="20250707091135" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway is inspired by the [Lipidmaps&gt;Sphingolipids pathway (all chain lengths)](https://lipidmaps.org/pathway/pathways_maps).
Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules.
This pathway shows all different tail lengths and their conversions into specific products. All products are annotated with lipid-specific identifiers (if available).
The general overview pathway can be found [here](https://www.wikipathways.org/index.php/Pathway:WP4344).</Comment>
  <BiopaxRef>f6b</BiopaxRef>
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    <Xref Database="ChEBI" ID="CHEBI:30616" />
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  <DataNode TextLabel="3-keto-sphinganine" GraphId="e703c" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP01020002" />
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  <DataNode TextLabel="Ppap2a" GraphId="ccdfa" Type="Protein" GroupRef="c9cc7">
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  <DataNode TextLabel="Cerk" GraphId="b872c" Type="Protein">
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  <DataNode TextLabel="Asah1" GraphId="d262d" Type="Protein">
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  <DataNode TextLabel="Palmitoyl-CoA" GraphId="e79a6" Type="Metabolite">
    <Comment>aka CoA(16:0)</Comment>
    <BiopaxRef>b6c</BiopaxRef>
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  <DataNode TextLabel="Sphk2" GraphId="ec90a" Type="Protein" GroupRef="e9c94">
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  <DataNode TextLabel="Sgpl1" GraphId="aacd8" Type="Protein">
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  <DataNode TextLabel="Ugcg" GraphId="d041a" Type="Protein">
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  <DataNode TextLabel="Serine" GraphId="bbf76" Type="Metabolite">
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  <DataNode TextLabel="Hexadecanal" GraphId="d8f79" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA06000088" />
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  <DataNode TextLabel="Sptlc1" GraphId="cc2ed" Type="Protein" GroupRef="ee7e5">
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  <DataNode TextLabel="Sphk1" GraphId="a14a8" Type="Protein" GroupRef="e9c94">
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  <DataNode TextLabel="Degs1" GraphId="cf753" Type="Protein" GroupRef="d2b68">
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  <DataNode TextLabel="Kdsr" GraphId="cccac" Type="Protein">
    <Comment>AKA Fvt1</Comment>
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  <DataNode TextLabel="Sptlc2" GraphId="db18a" Type="Protein" GroupRef="ee7e5">
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    <Xref Database="Uniprot-TrEMBL" ID="P97363" />
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  <DataNode TextLabel="Ethanolamine-phosphate" GraphId="ab939" Type="Metabolite">
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  <DataNode TextLabel="H₂O" GraphId="dd604" Type="Metabolite">
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  <DataNode TextLabel="Sphingosine" GraphId="f6010" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP01010001" />
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  <DataNode TextLabel="Sphinganine" GraphId="a0809" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
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    <Xref Database="LIPID MAPS" ID="LMSP01020001" />
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  <DataNode TextLabel="Sphinganine-1-phosphate" GraphId="eb7f3" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP01050002" />
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  <DataNode TextLabel="CerS4" GraphId="b8d4a" Type="Protein" GroupRef="f1b02">
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  <DataNode TextLabel="CerS5" GraphId="d18e8" Type="Protein" GroupRef="ec55e">
    <Comment>AKA Lass5</Comment>
    <BiopaxRef>f88</BiopaxRef>
    <BiopaxRef>d60</BiopaxRef>
    <BiopaxRef>b4a</BiopaxRef>
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  <DataNode TextLabel="CerS6" GraphId="f5d48" Type="Protein" GroupRef="ec55e">
    <Comment>AKA Lass6</Comment>
    <BiopaxRef>b4a</BiopaxRef>
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  <DataNode TextLabel="C16 CerP" GraphId="e59bc" Type="Metabolite">
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  <DataNode TextLabel="C16DH CerP" GraphId="cfdee" Type="Metabolite">
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  <DataNode TextLabel="C16 SM" GraphId="f4bbf" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
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    <Xref Database="LIPID MAPS" ID="LMSP03010003" />
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  <DataNode TextLabel="C16 GlcCer" GraphId="a5ca8" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP0501AA03" />
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  <DataNode TextLabel="C16DH SM" GraphId="e0930" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
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    <Xref Database="LIPID MAPS" ID="LMSP03010004" />
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  <DataNode TextLabel="C16DH GlcCer" GraphId="baf73" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP0501AA04" />
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  <DataNode TextLabel="C16 GalCer" GraphId="a9aa0" Type="Metabolite">
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  <DataNode TextLabel="C16DH GalCer" GraphId="ec374" Type="Metabolite">
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    <Xref Database="Entrez Gene" ID="20597" />
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    <Graphics CenterX="473.12736127419385" CenterY="503.42590515829676" Width="62.5" Height="18.5" ZOrder="33010" FontSize="12" Valign="Middle" />
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  <DataNode TextLabel="Sgms2" GraphId="ee229" Type="Protein" GroupRef="dbad2">
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  <DataNode TextLabel="Sphingosine-1-phosphate" GraphId="f2084" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP01050001" />
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  <DataNode TextLabel="1-Hexadecenal" GraphId="cc77f" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA06000088" />
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  <DataNode TextLabel="Ppap2b" GraphId="cdd52" Type="Protein" GroupRef="c9cc7">
    <Graphics CenterX="1200.5153823208593" CenterY="848.4186739609008" Width="63.0" Height="23.5" ZOrder="33014" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67916" />
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  <DataNode TextLabel="Ppap2c" GraphId="c70d1" Type="Protein" GroupRef="c9cc7">
    <Graphics CenterX="1200.5153823208593" CenterY="871.9186739609008" Width="63.0" Height="23.5" ZOrder="33015" FontSize="12" Valign="Middle" />
    <Xref Database="NCBI Protein" ID="50784" />
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  <DataNode TextLabel="Ugt8a" GraphId="dbb07" Type="Protein">
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    <Xref Database="Entrez Gene" ID="22239" />
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  <DataNode TextLabel="CoA(16:0)" GraphId="be53c" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA07050360" />
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  <DataNode TextLabel="CoA(18:0)" GraphId="fadb3" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA07050369" />
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  <DataNode TextLabel="CoA(20:0)" GraphId="dedfd" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA07050329" />
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  <DataNode TextLabel="CoA(22:0)" GraphId="afb32" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​docosanoate"</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA07050289" />
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  <DataNode TextLabel="CoA(24:0)" GraphId="ed529" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​(tetracosanoate)​"</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA07050372" />
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  <DataNode TextLabel="CoA(24:1)" GraphId="e7f29" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA07050098" />
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  <DataNode TextLabel="C16DH-Cer" GraphId="dd764" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMSP02020001" />
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  <DataNode TextLabel="CerS1" GraphId="c1570" Type="Protein" GroupRef="f1b02">
    <BiopaxRef>b4a</BiopaxRef>
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    <Xref Database="Uniprot-TrEMBL" ID="P27545" />
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  <DataNode TextLabel="CerS4" GraphId="f4edd" Type="Protein">
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  <DataNode TextLabel="Cers2" GraphId="f9b8e" Type="Protein">
    <Comment>Original LipidMaps annotation</Comment>
    <BiopaxRef>b4a</BiopaxRef>
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    <Xref Database="Entrez Gene" ID="76893" />
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  <DataNode TextLabel="CoA(26:0)" GraphId="d0eaa" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​hexacosanoate"</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA07050327" />
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  <DataNode TextLabel="CoA(26:1)" GraphId="ad81f" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA07050099" />
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    <Xref Database="Uniprot-TrEMBL" ID="Q1A3B0" />
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  <DataNode TextLabel="ADP" GraphId="e873a" Type="Metabolite">
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    <Xref Database="ChEBI" ID="CHEBI:456216" />
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    <Xref Database="Uniprot-TrEMBL" ID="Q810K3" />
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  <DataNode TextLabel="Sphk2" GraphId="cc11d" Type="Protein" GroupRef="a4b6e">
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    <Xref Database="Uniprot-TrEMBL" ID="Q9JIA7" />
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  <DataNode TextLabel="Sphk1" GraphId="c27d1" Type="Protein" GroupRef="a4b6e">
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    <Xref Database="Uniprot-TrEMBL" ID="Q8CI15" />
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  <DataNode TextLabel="Sgpl1" GraphId="e9c81" Type="Protein">
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    <Xref Database="Entrez Gene" ID="20397" />
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  <DataNode TextLabel="CerS4" GraphId="e2f78" Type="Protein">
    <BiopaxRef>b4a</BiopaxRef>
    <Graphics CenterX="988.7977050208906" CenterY="264.4445502003541" Width="52.95614268548025" Height="25.0" ZOrder="33056" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67260" />
  </DataNode>
  <DataNode TextLabel="Cers2" GraphId="d657f" Type="Protein">
    <Graphics CenterX="1226.6520265706956" CenterY="310.41721582661927" Width="52.956142685480245" Height="25.0" ZOrder="33057" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="76893" />
  </DataNode>
  <DataNode TextLabel="CerS4" GraphId="c248e" Type="Protein">
    <Comment>Protein found in literature (not in original LipidMapsPW)</Comment>
    <BiopaxRef>b4a</BiopaxRef>
    <Graphics CenterX="1511.4738472926372" CenterY="253.29564396797352" Width="52.95614268548025" Height="25.0" ZOrder="33059" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67260" />
  </DataNode>
  <DataNode TextLabel="CoA(14:0)" GraphId="a265d" Type="Metabolite">
    <Graphics CenterX="117.71825946285624" CenterY="215.79662535433326" Width="76.20140834040546" Height="25.000000000000004" ZOrder="33061" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C14DH-Ceramide" GraphId="c0d7e" Type="Metabolite">
    <Graphics CenterX="61.87691807093058" CenterY="398.52209859990097" Width="108.2099509805688" Height="25.000000000000004" ZOrder="33062" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="CerS5" GraphId="c6b8d" Type="Protein" GroupRef="e2566">
    <Comment>AKA Lass5</Comment>
    <BiopaxRef>b4a</BiopaxRef>
    <Graphics CenterX="123.33660132233057" CenterY="282.09031470412464" Width="52.95614268548025" Height="25.0" ZOrder="33063" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9D6K9" />
  </DataNode>
  <DataNode TextLabel="CerS6" GraphId="bf01f" Type="Protein" GroupRef="e2566">
    <Comment>AKA Lass6</Comment>
    <BiopaxRef>b4a</BiopaxRef>
    <Graphics CenterX="123.33660132233057" CenterY="307.09031470412475" Width="52.95614268548025" Height="25.0" ZOrder="33064" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8C172" />
  </DataNode>
  <DataNode TextLabel="C16 Cer" GraphId="ee093" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="278.3112458818351" CenterY="598.3820013773427" Width="94.41650879417699" Height="25.28203305094405" ZOrder="33065" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02010004" />
  </DataNode>
  <DataNode TextLabel="Cerk" GraphId="e8f47" Type="Protein">
    <Graphics CenterX="187.16039511425146" CenterY="526.7238774338734" Width="82.49999999999999" Height="20.00000000000001" ZOrder="33066" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="223753" />
  </DataNode>
  <DataNode TextLabel="Ugcg" GraphId="c2756" Type="Protein">
    <Graphics CenterX="187.16039511425143" CenterY="592.335155940161" Width="82.49999999999999" Height="23.880597014925364" ZOrder="33067" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22234" />
  </DataNode>
  <DataNode TextLabel="Smpd1" GraphId="b9085" Type="Protein">
    <Graphics CenterX="386.8234599417437" CenterY="593.9992469608264" Width="79.5" Height="21.500000000000018" ZOrder="33068" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20597" />
  </DataNode>
  <DataNode TextLabel="Sgms1" GraphId="d62b9" Type="Protein" GroupRef="ad0f5">
    <Graphics CenterX="386.8234599417437" CenterY="513.2675589772562" Width="79.5" Height="21.500000000000018" ZOrder="33069" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="208449" />
  </DataNode>
  <DataNode TextLabel="Sgms2" GraphId="c79e6" Type="Protein" GroupRef="ad0f5">
    <Graphics CenterX="386.8234599417437" CenterY="534.2675589772559" Width="79.5" Height="21.500000000000018" ZOrder="33070" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="74442" />
  </DataNode>
  <DataNode TextLabel="Ugt8a" GraphId="d85dd" Type="Protein">
    <Graphics CenterX="386.8234599417437" CenterY="620.8818550448259" Width="79.5" Height="20.00000000000001" ZOrder="33071" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22239" />
  </DataNode>
  <DataNode TextLabel="C18 CerP" GraphId="ab23f" Type="Metabolite">
    <Graphics CenterX="504.67191587995677" CenterY="557.1844680718984" Width="87.99702178113748" Height="28.500000000000032" ZOrder="33073" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C18DH CerP" GraphId="ea9a6" Type="Metabolite">
    <Graphics CenterX="504.67191587995677" CenterY="362.2096838085327" Width="87.99702178113748" Height="28.500000000000007" ZOrder="33074" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C18 SM" GraphId="ee08b" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="696.582722878482" CenterY="557.1844680718984" Width="80.1485915924447" Height="28.5" ZOrder="33075" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010001" />
  </DataNode>
  <DataNode TextLabel="C18 GlcCer" GraphId="cd624" Type="Metabolite">
    <Graphics CenterX="504.6719158799567" CenterY="631.8824772819072" Width="87.99702178113748" Height="28.499999999999982" ZOrder="33076" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA05" />
  </DataNode>
  <DataNode TextLabel="C18DH SM" GraphId="c2e38" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="662.134986926012" CenterY="362.2096838085327" Width="87.26368110650976" Height="28.5" ZOrder="33077" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010020" />
  </DataNode>
  <DataNode TextLabel="C18DH GlcCer" GraphId="e98fe" Type="Metabolite">
    <Graphics CenterX="504.67191587995677" CenterY="453.68697860816246" Width="87.99702178113742" Height="28.5" ZOrder="33078" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA19" />
  </DataNode>
  <DataNode TextLabel="C18 GalCer" GraphId="a518f" Type="Metabolite">
    <Graphics CenterX="662.134986926012" CenterY="631.8824772819072" Width="91.8771884833225" Height="28.5" ZOrder="33079" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C18DH GalCer" GraphId="b4d89" Type="Metabolite">
    <Graphics CenterX="662.134986926012" CenterY="453.6869786081625" Width="108.50122940403917" Height="28.5" ZOrder="33080" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C18DH-Cer" GraphId="e5f2b" Type="Metabolite">
    <Graphics CenterX="586.2564513612868" CenterY="408.5550217034988" Width="94.90557318028613" Height="25.000000000000004" ZOrder="33081" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020008" />
  </DataNode>
  <DataNode TextLabel="C18 Cer" GraphId="a223b" Type="Metabolite">
    <Graphics CenterX="586.2564513612875" CenterY="594.9872493032599" Width="94.41650879417699" Height="25.28203305094405" ZOrder="33082" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02010006" />
  </DataNode>
  <DataNode TextLabel="C20 CerP" GraphId="fe480" Type="Metabolite">
    <Graphics CenterX="760.9769711562282" CenterY="516.196044110362" Width="87.99702178113748" Height="28.500000000000032" ZOrder="33093" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C20DH CerP" GraphId="d302f" Type="Metabolite">
    <Graphics CenterX="760.9769711562283" CenterY="323.17858446076843" Width="87.99702178113748" Height="28.500000000000007" ZOrder="33094" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C20 SM" GraphId="f03df" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="891.6228051999727" CenterY="516.196044110362" Width="80.1485915924447" Height="28.5" ZOrder="33095" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010005" />
  </DataNode>
  <DataNode TextLabel="C20 GlcCer" GraphId="d69bf" Type="Metabolite">
    <Graphics CenterX="760.9769711562283" CenterY="603.5896329676987" Width="87.99702178113748" Height="28.499999999999982" ZOrder="33096" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA06" />
  </DataNode>
  <DataNode TextLabel="C20DH SM" GraphId="e4386" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="894.8854479405926" CenterY="323.17858446076843" Width="87.26368110650976" Height="28.5" ZOrder="33097" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010021" />
  </DataNode>
  <DataNode TextLabel="C20DH GlcCer" GraphId="acbd8" Type="Metabolite">
    <Graphics CenterX="760.9769711562283" CenterY="420.0250067771768" Width="87.99702178113742" Height="28.5" ZOrder="33098" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA20" />
  </DataNode>
  <DataNode TextLabel="C20 GalCer" GraphId="c65ae" Type="Metabolite">
    <Graphics CenterX="893.2541265702828" CenterY="603.5896329676985" Width="91.8771884833225" Height="28.5" ZOrder="33099" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C20DH GalCer" GraphId="b4b09" Type="Metabolite">
    <Graphics CenterX="894.8854479405926" CenterY="420.0250067771768" Width="108.50122940403917" Height="28.5" ZOrder="33100" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C20DH-Cer" GraphId="e8978" Type="Metabolite">
    <Graphics CenterX="827.7880079026652" CenterY="374.89304987251313" Width="94.90557318028613" Height="25.000000000000004" ZOrder="33101" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020009" />
  </DataNode>
  <DataNode TextLabel="C20 Cer" GraphId="ac886" Type="Metabolite">
    <Graphics CenterX="827.788007902666" CenterY="561.3252774722775" Width="94.41650879417699" Height="25.28203305094405" ZOrder="33102" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02010007" />
  </DataNode>
  <DataNode TextLabel="C22 CerP" GraphId="e4e6f" Type="Metabolite">
    <Graphics CenterX="988.7977050208906" CenterY="486.6126420657736" Width="87.99702178113748" Height="28.500000000000032" ZOrder="33113" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C22DH CerP" GraphId="b25a5" Type="Metabolite">
    <Graphics CenterX="988.7977050208905" CenterY="300.22074825871175" Width="87.99702178113748" Height="28.500000000000007" ZOrder="33114" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C22 SM" GraphId="b3f40" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="1142.7528038120327" CenterY="486.61264206577357" Width="80.1485915924447" Height="28.5" ZOrder="33115" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010006" />
  </DataNode>
  <DataNode TextLabel="C22 GlcCer" GraphId="f1efe" Type="Metabolite">
    <Graphics CenterX="988.7977050208906" CenterY="567.0057820360219" Width="87.99702178113748" Height="28.499999999999982" ZOrder="33116" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA07" />
  </DataNode>
  <DataNode TextLabel="C22DH SM" GraphId="b8d18" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="1142.7528038120329" CenterY="300.2207482587118" Width="87.26368110650976" Height="28.5" ZOrder="33117" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010022" />
  </DataNode>
  <DataNode TextLabel="C22DH GlcCer" GraphId="a84b1" Type="Metabolite">
    <Graphics CenterX="990.4290263912006" CenterY="383.4411558455" Width="87.99702178113742" Height="28.5" ZOrder="33118" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA21" />
  </DataNode>
  <DataNode TextLabel="C22 GalCer" GraphId="bae01" Type="Metabolite">
    <Graphics CenterX="1142.7528038120329" CenterY="567.0057820360219" Width="91.8771884833225" Height="28.5" ZOrder="33119" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C22DH GalCer" GraphId="aaba9" Type="Metabolite">
    <Graphics CenterX="1142.7528038120327" CenterY="383.4411558455" Width="108.50122940403917" Height="28.5" ZOrder="33120" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C22DH-Cer" GraphId="d12ab" Type="Metabolite">
    <Graphics CenterX="1079.405705505347" CenterY="333.6688277111379" Width="94.90557318028613" Height="25.000000000000004" ZOrder="33121" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020010" />
  </DataNode>
  <DataNode TextLabel="C22 Cer" GraphId="ec73f" Type="Metabolite">
    <Graphics CenterX="1079.4057055053477" CenterY="524.7414265406007" Width="94.41650879417699" Height="25.28203305094405" ZOrder="33122" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02010008" />
  </DataNode>
  <DataNode TextLabel="C24 CerP" GraphId="ae6a5" Type="Metabolite">
    <Graphics CenterX="1378.4684878906855" CenterY="488.64924284549863" Width="87.99702178113748" Height="28.500000000000032" ZOrder="33134" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24DH CerP" GraphId="e50cb" Type="Metabolite">
    <Graphics CenterX="1378.4684878906855" CenterY="300.5257473068355" Width="87.99702178113748" Height="28.500000000000007" ZOrder="33135" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24 SM" GraphId="c23d6" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="1532.4235866818276" CenterY="488.64924284549784" Width="80.1485915924447" Height="28.5" ZOrder="33136" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010008" />
  </DataNode>
  <DataNode TextLabel="C24 GlcCer" GraphId="bb0cf" Type="Metabolite">
    <Graphics CenterX="1378.4684878906855" CenterY="569.0423828157453" Width="87.99702178113748" Height="28.499999999999982" ZOrder="33137" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA09" />
  </DataNode>
  <DataNode TextLabel="C24DH SM" GraphId="a0374" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="1546.626298108555" CenterY="293.4243915934712" Width="87.26368110650976" Height="28.5" ZOrder="33138" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010024" />
  </DataNode>
  <DataNode TextLabel="C24DH GlcCer" GraphId="ac9b7" Type="Metabolite">
    <Graphics CenterX="1380.0998092609957" CenterY="385.47775662522474" Width="87.99702178113742" Height="28.5" ZOrder="33139" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA23" />
  </DataNode>
  <DataNode TextLabel="C24 GalCer" GraphId="f193c" Type="Metabolite">
    <Graphics CenterX="1532.4235866818278" CenterY="569.0423828157456" Width="91.8771884833225" Height="28.5" ZOrder="33140" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24DH GalCer" GraphId="f97e3" Type="Metabolite">
    <Graphics CenterX="1532.4235866818276" CenterY="385.47775662522474" Width="108.50122940403917" Height="28.5" ZOrder="33141" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24DH-Cer" GraphId="ba745" Type="Metabolite">
    <Graphics CenterX="1457.2724553687324" CenterY="335.7054284908628" Width="94.90557318028613" Height="25.000000000000004" ZOrder="33142" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020012" />
  </DataNode>
  <DataNode TextLabel="C24 Cer" GraphId="b238d" Type="Metabolite">
    <Graphics CenterX="1457.2724553687333" CenterY="526.7780273203268" Width="94.41650879417699" Height="25.28203305094405" ZOrder="33143" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02010012" />
  </DataNode>
  <DataNode TextLabel="C24:1 CerP" GraphId="e703b" Type="Metabolite">
    <Graphics CenterX="1184.780955979741" CenterY="530.7687924780644" Width="87.99702178113748" Height="28.500000000000032" ZOrder="33154" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24:1DH CerP" GraphId="c44f9" Type="Metabolite">
    <Graphics CenterX="1184.7809559797408" CenterY="342.6452969394011" Width="87.99702178113748" Height="28.500000000000007" ZOrder="33155" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24:1 SM" GraphId="da8d8" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="1338.7360547708834" CenterY="530.768792478064" Width="80.1485915924447" Height="28.5" ZOrder="33156" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010007" />
  </DataNode>
  <DataNode TextLabel="C24:1 GlcCer" GraphId="ca0d7" Type="Metabolite">
    <Graphics CenterX="1184.780955979741" CenterY="611.1619324483124" Width="87.99702178113748" Height="28.499999999999982" ZOrder="33157" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA08" />
  </DataNode>
  <DataNode TextLabel="C24:1DH SM" GraphId="d0c7d" Type="Metabolite">
    <Comment>SM = sphingomyelin</Comment>
    <Graphics CenterX="1338.7360547708836" CenterY="342.64529693940113" Width="87.26368110650976" Height="28.5" ZOrder="33158" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP03010023" />
  </DataNode>
  <DataNode TextLabel="C24:1DH GlcCer" GraphId="ef3a5" Type="Metabolite">
    <Graphics CenterX="1186.412277350051" CenterY="427.5973062577911" Width="87.99702178113742" Height="28.5" ZOrder="33159" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA22" />
  </DataNode>
  <DataNode TextLabel="C24:1 GalCer" GraphId="c178a" Type="Metabolite">
    <Graphics CenterX="1338.7360547708836" CenterY="611.1619324483124" Width="91.8771884833225" Height="28.5" ZOrder="33160" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24:1DH GalCer" GraphId="dc4b5" Type="Metabolite">
    <Graphics CenterX="1338.7360547708834" CenterY="427.5973062577911" Width="108.50122940403917" Height="28.5" ZOrder="33161" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="C24:1DH-Cer" GraphId="aa425" Type="Metabolite">
    <Graphics CenterX="1262.8375393023323" CenterY="377.824978123429" Width="94.90557318028613" Height="25.000000000000004" ZOrder="33162" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020011" />
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  <DataNode TextLabel="C24:1 Cer" GraphId="b147c" Type="Metabolite">
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    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b4a">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15823095</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem J</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mizutani Y</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kihara A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Igarashi Y</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingomyelin metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000745</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f88">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16100120</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lahiri S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Futerman AH</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingolipid metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000197</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11756451</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Characterization of murine sphingosine-1-phosphate phosphohydrolase.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Le Stunff H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peterson C</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thornton R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milstien S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mandala SM</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spiegel S</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b6c">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12011104</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merrill AH Jr</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d60">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26853464</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gosejacob D</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jäger PS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vom Dorp K</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frejno M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carstensen AC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Köhnke M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Degen J</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dörmann P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoch M</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f6b">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20923771</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mouse macrophage lipidome.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dennis EA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Deems RA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harkewicz R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quehenberger O</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown HA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milne SB</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Myers DS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glass CK</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hardiman G</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reichart D</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merrill AH Jr</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sullards MC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murphy RC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Raetz CR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Garrett TA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guan Z</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ryan AC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Russell DW</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McDonald JG</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thompson BM</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shaw WA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sud M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhao Y</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gupta S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maurya MR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fahy E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Subramaniam S</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d6d">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17977534</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FEBS Lett</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lahiri S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mesicek J</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fuks Z</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Haimovitz-Friedman A</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kolesnick RN</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Futerman AH</bp:AUTHORS>
    </bp:PublicationXref>
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