<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Myometrial relaxation and contraction pathways" Data-Source="WikiPathways" Version="WP385_r122794" Author="[Nsalomonis, MaintBot, Khanspers, Thomas, MartijnVanIersel, Mkutmon, AlexanderPico, Elisa, L Dupuis, Fehrhart, Eweitz]" Last-Modified="20220518012748" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.</Comment>
  <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP289_r89548 WP289 (r89548)] with a 96.0% conversion rate.</Comment>
  <BiopaxRef>d18</BiopaxRef>
  <BiopaxRef>d04</BiopaxRef>
  <BiopaxRef>d43</BiopaxRef>
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  <DataNode TextLabel="Ramp1" GraphId="a0606" Type="GeneProduct" GroupRef="bcf55">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10267</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000034353" />
  </DataNode>
  <DataNode TextLabel="Igfbp6" GraphId="a107e" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3489</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGFBP6 | insulin-like growth factor binding pro..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000023046" />
  </DataNode>
  <DataNode TextLabel="Gng13" GraphId="a18e0" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:51764</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG13 | guanine nucleotide binding protein (G p..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000025739" />
  </DataNode>
  <DataNode TextLabel="Rgs11" GraphId="a2e1d" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8786</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS11 | regulator of G-protein signalling 11" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000024186" />
  </DataNode>
  <DataNode TextLabel="Prkcz" GraphId="a3acd" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5590</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCZ | protein kinase C zeta" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000029053" />
  </DataNode>
  <DataNode TextLabel="Adcy5" GraphId="a423a" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">There is no SwissProt entry for a full-length sequence in mouse.  This EST is from the Affymetrix Murine6500 chip.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:111</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY5 | adenylate cyclase 5" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000022840" />
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  <DataNode TextLabel="Ryr1" GraphId="a47f7" Type="GeneProduct" GroupRef="b8909">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6261</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RYR1 | ryanodine receptor 1 (skeletal)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000030592" />
  </DataNode>
  <DataNode TextLabel="Atp2a3" GraphId="a4807" Type="GeneProduct" GroupRef="b8909">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:489</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP2A3 | ATPase Ca++ transporting ubiquitous" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000020788" />
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  <DataNode TextLabel="Atf4" GraphId="a4dce" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:468</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATF4 | activating transcription factor 4 (tax-r..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000042406" />
  </DataNode>
  <DataNode TextLabel="GUCY2E" GraphId="a6668" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PMID: 11854458</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GUCY2E | guanylate cyclase 2E" />
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="Prkar2b" GraphId="a67e2" Type="GeneProduct" GroupRef="cb90f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5577</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKAR2B | protein kinase cAMP-dependent regul..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000002997" />
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  <DataNode TextLabel="Prkcg" GraphId="a687f" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5582</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCG | protein kinase C gamma" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000078816" />
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  <DataNode TextLabel="Adcy2" GraphId="a6920" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">There is no SwissProt entry for a full-length sequence in mouse.  This EST is from the Affymetrix Murine6500 chip.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:108</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY2 | adenylate cyclase 2 (brain)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021536" />
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  <DataNode TextLabel="Prkce" GraphId="a793d" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="GenMAPP remarks">This EST is listed on the Affymetrix Murine6500 chip.  The SwissProt entry name is KPCE MOUSE.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5581</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCE | protein kinase C epsilon" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000045038" />
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  <DataNode TextLabel="Igfbp5" GraphId="a801e" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3488</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGFBP5 | insulin-like growth factor binding pro..." />
    <Graphics CenterX="160.0" CenterY="772.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026185" />
  </DataNode>
  <DataNode TextLabel="Grk4" GraphId="a88ca" Type="GeneProduct" GroupRef="e2890">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2868</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK4 | G protein-coupled receptor kinase 4" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000052783" />
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  <DataNode TextLabel="Gnb3" GraphId="a8c0b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2784</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB3 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="406.66666666666663" CenterY="727.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000023439" />
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  <DataNode TextLabel="Gng3" GraphId="a90c2" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2785</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG3 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000071658" />
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  <DataNode TextLabel="Pkib" GraphId="a9375" Type="GeneProduct" GroupRef="b262c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5570</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PKIB | protein kinase (cAMP-dependent catalyti..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000019876" />
  </DataNode>
  <DataNode TextLabel="Fos" GraphId="a9700" Type="GeneProduct" GroupRef="de038">
    <Comment Source="GenMAPP remarks">PMID: 10218980 PMID: 7628395 [</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2353</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOS | v-fos FBJ murine osteosarcoma viral oncog..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021250" />
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  <DataNode TextLabel="Grk5" GraphId="aa50b" Type="GeneProduct" GroupRef="b01f5">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK5 | G protein-coupled receptor kinase 5" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000003228" />
  </DataNode>
  <DataNode TextLabel="Oxtr" GraphId="aa684" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5021</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="OXTR | oxytocin receptor" />
    <Graphics CenterX="740.0" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000049112" />
  </DataNode>
  <DataNode TextLabel="Mylk2" GraphId="aaf0e" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">KML2 MOUSE</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:85366</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYLK2 | myosin light chain kinase 2 skeletal m..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000027470" />
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  <DataNode TextLabel="Gng12" GraphId="ab67b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:55970</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG12 | guanine nucleotide binding protein (G p..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000036402" />
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  <DataNode TextLabel="Rgs2" GraphId="ab727" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5997</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS2 | regulator of G-protein signalling 2 24k..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000026360" />
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  <DataNode TextLabel="Gng2" GraphId="ab9bd" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:54331</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG2 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000043004" />
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  <DataNode TextLabel="Rgs6" GraphId="abc52" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9628</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS6 | regulator of G-protein signalling 6" />
    <Graphics CenterX="1183.9999999999998" CenterY="253.00000000000003" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021219" />
  </DataNode>
  <DataNode TextLabel="Jun" GraphId="acae1" Type="GeneProduct" GroupRef="de038">
    <Comment Source="GenMAPP remarks">PMID: 10218980</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="JUN | v-jun sarcoma virus 17 oncogene homolog (..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000052684" />
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  <DataNode TextLabel="Adcy3" GraphId="ad089" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:109</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY3 | adenylate cyclase 3" />
    <Graphics CenterX="250.0" CenterY="732.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020654" />
  </DataNode>
  <DataNode TextLabel="Gng7" GraphId="ad169" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2788</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG7 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000048240" />
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  <DataNode TextLabel="Prkacb" GraphId="ad751" Type="GeneProduct" GroupRef="cb90f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5567</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKACB | protein kinase cAMP-dependent cataly..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000005034" />
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  <DataNode TextLabel="Atf6b" GraphId="ae2ef" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1388</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CREBL1 | cAMP responsive element binding protei..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000015461" />
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  <DataNode TextLabel="ACTA2" GraphId="af2af" Type="GeneProduct" GroupRef="b38f8">
    <Comment Source="HomologyMapper">No homologues found for original id L:59</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACTA2 | actin alpha 2 smooth muscle aorta" />
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="Ramp2" GraphId="b0d8d" Type="GeneProduct" GroupRef="bcf55">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10266</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAMP2 | receptor (calcitonin) activity modifyin..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000001240" />
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  <DataNode TextLabel="Gpr182" GraphId="b0eff" Type="GeneProduct" GroupRef="aa636">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11318</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADMR | adrenomedullin receptor" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000058396" />
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  <DataNode TextLabel="Calca" GraphId="b14d3" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CRF HUMAN  PMID: 11854458</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:796</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALCA | calcitonin/calcitonin-related polypepti..." />
    <Graphics CenterX="250.0" CenterY="102.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030669" />
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  <DataNode TextLabel="Adcy8" GraphId="b1983" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:114</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY8 | adenylate cyclase 8 (brain)" />
    <Graphics CenterX="318.66666666666663" CenterY="732.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022376" />
  </DataNode>
  <DataNode TextLabel="Adcy1" GraphId="b209c" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CYA1 HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:107</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY1 | adenylate cyclase 1 (brain)" />
    <Graphics CenterX="250.0" CenterY="692.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020431" />
  </DataNode>
  <DataNode TextLabel="Arrb2" GraphId="b27a1" Type="GeneProduct" GroupRef="e2890">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB2 | arrestin beta 2" />
    <Graphics CenterX="899.3333333333333" CenterY="218.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000060216" />
  </DataNode>
  <DataNode TextLabel="Atf1" GraphId="b2e46" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:466</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATF1 | activating transcription factor 1" />
    <Graphics CenterX="63.0" CenterY="572.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000023027" />
  </DataNode>
  <DataNode TextLabel="Nos1" GraphId="b343a" Type="GeneProduct" GroupRef="dc048">
    <Comment Source="GenMAPP remarks">PMID: 11854458</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4842</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NOS1 | nitric oxide synthase 1 (neuronal)" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000029361" />
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  <DataNode TextLabel="Grk5" GraphId="b36cd" Type="GeneProduct" GroupRef="e2890">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK5 | G protein-coupled receptor kinase 5" />
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  <DataNode TextLabel="Rgs17" GraphId="b43ea" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:26575</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS17 | regulator of G-protein signalling 17" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000019775" />
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  <DataNode TextLabel="Prkch" GraphId="b5442" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5583</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCH | protein kinase C eta" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021108" />
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  <DataNode TextLabel="Ryr2" GraphId="b54bb" Type="GeneProduct" GroupRef="b8909">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6262</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RYR2 | ryanodine receptor 2 (cardiac)" />
    <Graphics CenterX="644.3333333333334" CenterY="452.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021313" />
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  <DataNode TextLabel="Rgs18" GraphId="b5c1f" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:64407</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS18 | regulator of G-protein signalling 18" />
    <Graphics CenterX="1258.6666666666663" CenterY="253.00000000000003" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026357" />
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  <DataNode TextLabel="Ywhab" GraphId="b5ebe" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7529</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAB | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1195.9999999999998" CenterY="486.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018326" />
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  <DataNode TextLabel="Il6" GraphId="b64a3" Type="GeneProduct" GroupRef="c509b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3569</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6 | interleukin 6 (interferon beta 2)" />
    <Graphics CenterX="788.0000000000005" CenterY="920.6666666666671" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025746" />
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  <DataNode TextLabel="Grk6" GraphId="b6ea2" Type="GeneProduct" GroupRef="e2890">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2870</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK6 | G protein-coupled receptor kinase 6" />
    <Graphics CenterX="899.3333333333333" CenterY="178.66666666666663" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000074886" />
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  <DataNode TextLabel="Crcp" GraphId="b7107" Type="GeneProduct" GroupRef="bcf55">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27297</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RCP9 | calcitonin gene-related peptide-receptor..." />
    <Graphics CenterX="250.0" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025532" />
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  <DataNode TextLabel="Rxfp1" GraphId="b79ad" Type="GeneProduct" GroupRef="ca8b3">
    <Comment Source="GenMAPP remarks">PMID: 11809971</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59350</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="LGR7 | leucine-rich repeat-containing G protein..." />
    <Graphics CenterX="96.66666666666667" CenterY="150.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000034009" />
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  <DataNode TextLabel="Cnn1" GraphId="b7f49" Type="GeneProduct" GroupRef="af3f8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1264</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CNN1 | calponin 1 basic smooth muscle" />
    <Graphics CenterX="976.6666666666666" CenterY="470.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000001349" />
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  <DataNode TextLabel="Ywhah" GraphId="b91ee" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7533</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAH | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1195.9999999999998" CenterY="526.6666666666665" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018965" />
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  <DataNode TextLabel="Camk2g" GraphId="b9259" Type="GeneProduct" GroupRef="da70b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:818</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2G | calcium/calmodulin-dependent protein k..." />
    <Graphics CenterX="1175.9999999999998" CenterY="670.0" Width="65.23876666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021820" />
  </DataNode>
  <DataNode TextLabel="Rgs7" GraphId="b9f6b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6000</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS7 | regulator of G-protein signalling 7" />
    <Graphics CenterX="1183.9999999999998" CenterY="273.0000000000001" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026527" />
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  <DataNode TextLabel="Myl4" GraphId="bab36" Type="GeneProduct" GroupRef="e8d60">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4635</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYL4 | myosin light polypeptide 4 alkali; atr..." />
    <Graphics CenterX="926.6666666666666" CenterY="616.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000061086" />
  </DataNode>
  <DataNode TextLabel="Rgs1" GraphId="bb0b7" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5996</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS1 | regulator of G-protein signalling 1" />
    <Graphics CenterX="1183.9999999999998" CenterY="153.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026358" />
  </DataNode>
  <DataNode TextLabel="Prkcb" GraphId="bb4cb" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5579</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCB1 | protein kinase C beta 1" />
    <Graphics CenterX="1191.9999999999998" CenterY="367.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000052889" />
  </DataNode>
  <DataNode TextLabel="Mylk2" GraphId="bb691" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">KML2 MOUSE</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:85366</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYLK2 | myosin light chain kinase 2 skeletal m..." />
    <Graphics CenterX="851.4514767932492" CenterY="531.059071729958" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027470" />
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  <DataNode TextLabel="Lpar1" GraphId="bb7d5" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1902</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDG2 | endothelial differentiation lysophospha..." />
    <Graphics CenterX="640.0" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038668" />
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  <DataNode TextLabel="Ramp3" GraphId="bc736" Type="GeneProduct" GroupRef="bcf55">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10268</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAMP3 | receptor (calcitonin) activity modifyin..." />
    <Graphics CenterX="250.33333333333331" CenterY="220.66666666666663" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000041046" />
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  <DataNode TextLabel="Camk2d" GraphId="bd5c4" Type="GeneProduct" GroupRef="da70b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:817</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2D | calcium/calmodulin-dependent protein k..." />
    <Graphics CenterX="1175.9999999999998" CenterY="650.0" Width="65.23876666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000053819" />
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  <DataNode TextLabel="Prkcq" GraphId="bdee2" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5588</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCQ | protein kinase C theta" />
    <Graphics CenterX="1251.9999999999998" CenterY="407.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026778" />
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  <DataNode TextLabel="Nos3" GraphId="be628" Type="GeneProduct" GroupRef="dc048">
    <Comment Source="GenMAPP remarks">PMID: 11854458</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4846</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NOS3 | nitric oxide synthase 3 (endothelial cel..." />
    <Graphics CenterX="476.6666666666667" CenterY="486.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000028978" />
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  <DataNode TextLabel="Cald1" GraphId="beb0c" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:800</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALD1 | caldesmon 1" />
    <Graphics CenterX="1053.3333333333333" CenterY="563.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029761" />
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  <DataNode TextLabel="Gsto1" GraphId="bf28c" Type="GeneProduct" GroupRef="b8909">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9446</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GSTO1 | glutathione S-transferase omega 1" />
    <Graphics CenterX="644.3333333333334" CenterY="492.33333333333326" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025068" />
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  <DataNode TextLabel="Crh" GraphId="bf458" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">CRF HUMAN  PMID: 11854458</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1392</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CRH | corticotropin releasing hormone" />
    <Graphics CenterX="330.0" CenterY="102.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000049796" />
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  <DataNode TextLabel="ATP" GraphId="c03e8" Type="Metabolite">
    <Graphics CenterX="915.6666666666666" CenterY="538.6666666666666" Width="31.333333333333332" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="1927-31-7" />
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  <DataNode TextLabel="Prkca" GraphId="c17cd" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5578</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCA | protein kinase C alpha" />
    <Graphics CenterX="1191.9999999999998" CenterY="347.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000050965" />
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  <DataNode TextLabel="Ywhaz" GraphId="c1939" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="GenMAPP remarks">PMID: 9861170 PMID: 1317796</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7534</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1254.6666666666663" CenterY="526.6666666666665" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022285" />
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  <DataNode TextLabel="Grk4" GraphId="c1c8f" Type="GeneProduct" GroupRef="b01f5">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2868</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK4 | G protein-coupled receptor kinase 4" />
    <Graphics CenterX="32.33333333333326" CenterY="246.66666666666669" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000052783" />
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  <DataNode TextLabel="CNN2" GraphId="c3f03" Type="GeneProduct" GroupRef="af3f8">
    <Comment Source="HomologyMapper">No homologues found for original id L:1265</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CNN2 | calponin 2" />
    <Graphics CenterX="976.6666666666666" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
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  <DataNode TextLabel="Prkar2a" GraphId="c415e" Type="GeneProduct" GroupRef="cb90f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5576</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKAR2A | protein kinase cAMP-dependent regul..." />
    <Graphics CenterX="227.33333333333331" CenterY="492.0" Width="71.16953333333332" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032601" />
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  <DataNode TextLabel="Arrb2" GraphId="c47dc" Type="GeneProduct" GroupRef="b01f5">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB2 | arrestin beta 2" />
    <Graphics CenterX="92.33333333333326" CenterY="286.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000060216" />
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  <DataNode TextLabel="Gnb2" GraphId="c5d97" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2783</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB2 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="406.66666666666663" CenterY="707.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029713" />
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  <DataNode TextLabel="Gng11" GraphId="c6e12" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2791</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG11 | guanine nucleotide binding protein (G p..." />
    <Graphics CenterX="532.6666666666666" CenterY="727.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032766" />
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  <DataNode TextLabel="Oxtr" GraphId="c758d" Type="GeneProduct" GroupRef="e60e9">
    <Comment Source="GenMAPP remarks">Sladek SM, Westerhausen-Larson A, Roberts JM. PMID: 10377025</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5021</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="OXTR | oxytocin receptor" />
    <Graphics CenterX="946.0000000000005" CenterY="864.0000000000003" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000049112" />
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  <DataNode TextLabel="Igfbp4" GraphId="c85c0" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3487</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGFBP4 | insulin-like growth factor binding pro..." />
    <Graphics CenterX="160.0" CenterY="752.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000017493" />
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  <DataNode TextLabel="Ryr3" GraphId="c881a" Type="GeneProduct" GroupRef="b8909">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6263</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RYR3 | ryanodine receptor 3" />
    <Graphics CenterX="644.3333333333334" CenterY="472.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000057378" />
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  <DataNode TextLabel="Rgs10" GraphId="ca15b" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6001</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS10 | regulator of G-protein signalling 10" />
    <Graphics CenterX="1258.6666666666663" CenterY="153.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030844" />
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  <DataNode TextLabel="Dgkz" GraphId="ca546" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8525</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="DGKZ | diacylglycerol kinase zeta 104kDa" />
    <Graphics CenterX="826.0" CenterY="273.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000040479" />
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  <DataNode TextLabel="Rgs5" GraphId="cadda" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8490</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS5 | regulator of G-protein signalling 5" />
    <Graphics CenterX="1183.9999999999998" CenterY="233.00000000000003" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026678" />
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  <DataNode TextLabel="Atp2a2" GraphId="cb5f1" Type="GeneProduct" GroupRef="b8909">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:488</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP2A2 | ATPase Ca++ transporting cardiac mus..." />
    <Graphics CenterX="644.3333333333334" CenterY="392.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029467" />
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  <DataNode TextLabel="Igfbp2" GraphId="cb61e" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3485</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGFBP2 | insulin-like growth factor binding pro..." />
    <Graphics CenterX="160.0" CenterY="712.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000039323" />
  </DataNode>
  <DataNode TextLabel="Rgs20" GraphId="cd585" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8601</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS20 | regulator of G-protein signalling 20" />
    <Graphics CenterX="1258.6666666666663" CenterY="293.0000000000001" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000002459" />
  </DataNode>
  <DataNode TextLabel="Gnaq" GraphId="cd799" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2776</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAQ | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="740.0" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024639" />
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  <DataNode TextLabel="Cyclic AMP" GraphId="cded0" Type="Metabolite">
    <Graphics CenterX="625.5" CenterY="205.0" Width="63.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0000058" />
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  <DataNode TextLabel="Gnb5" GraphId="ce263" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10681</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB5 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="406.66666666666663" CenterY="767.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032192" />
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  <DataNode TextLabel="Ywhae" GraphId="cf09c" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7531</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAE | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1195.9999999999998" CenterY="506.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020849" />
  </DataNode>
  <DataNode TextLabel="Oxt" GraphId="cf1e9" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MGI:97453</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5020</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="OXT | oxytocin prepro- (neurophysin I)" />
    <Graphics CenterX="740.0" CenterY="110.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027301" />
  </DataNode>
  <DataNode TextLabel="Prkar1a" GraphId="cf296" Type="GeneProduct" GroupRef="cb90f">
    <Comment Source="GenMAPP remarks">KAP0 HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5573</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKAR1A | protein kinase cAMP-dependent regul..." />
    <Graphics CenterX="227.33333333333331" CenterY="452.0" Width="71.16953333333332" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020612" />
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  <DataNode TextLabel="Rgs9" GraphId="d01f9" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8787</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS9 | regulator of G-protein signalling 9" />
    <Graphics CenterX="1183.9999999999998" CenterY="293.0000000000001" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020599" />
  </DataNode>
  <DataNode TextLabel="Sfn" GraphId="d0418" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2810</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SFN | stratifin" />
    <Graphics CenterX="1254.6666666666663" CenterY="486.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000047281" />
  </DataNode>
  <DataNode TextLabel="Adcy7" GraphId="d0cd8" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:113</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY7 | adenylate cyclase 7" />
    <Graphics CenterX="318.66666666666663" CenterY="712.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031659" />
  </DataNode>
  <DataNode TextLabel="Atf5" GraphId="d0f38" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22809</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATF5 | activating transcription factor 5" />
    <Graphics CenterX="63.0" CenterY="652.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038539" />
  </DataNode>
  <DataNode TextLabel="Plcg2" GraphId="d1223" Type="GeneProduct" GroupRef="f2693">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5336</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCG2 | phospholipase C gamma 2 (phosphatidyli..." />
    <Graphics CenterX="1271.9999999999998" CenterY="670.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000034330" />
  </DataNode>
  <DataNode TextLabel="Il1b" GraphId="d152d" Type="GeneProduct" GroupRef="c509b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3553</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL1B | interleukin 1 beta" />
    <Graphics CenterX="788.0000000000005" CenterY="900.6666666666671" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027398" />
  </DataNode>
  <DataNode TextLabel="Gng5" GraphId="d1649" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2787</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG5 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="472.33333333333337" CenterY="767.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000068523" />
  </DataNode>
  <DataNode TextLabel="Adm" GraphId="d2491" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:133</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADM | adrenomedullin" />
    <Graphics CenterX="173.33333333333334" CenterY="101.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030790" />
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  <DataNode TextLabel="Rgs16" GraphId="d2fab" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6004</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS16 | regulator of G-protein signalling 16" />
    <Graphics CenterX="1258.6666666666663" CenterY="213.00000000000034" Width="60.0" Height="20.00000000000003" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026475" />
  </DataNode>
  <DataNode TextLabel="Itpr3" GraphId="d3ad5" Type="GeneProduct" GroupRef="a15ef">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3710</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITPR3 | inositol 145-triphosphate receptor t..." />
    <Graphics CenterX="646.3333333333333" CenterY="344.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000042644" />
  </DataNode>
  <DataNode TextLabel="Prkd1" GraphId="d902e" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="GenMAPP remarks">KPCM HUMAN</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5587</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKD1 | protein kinase D1" />
    <Graphics CenterX="1251.9999999999998" CenterY="387.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000002688" />
  </DataNode>
  <DataNode TextLabel="Actg1" GraphId="d97c8" Type="GeneProduct" GroupRef="b38f8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:71</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACTG1 | actin gamma 1" />
    <Graphics CenterX="643.3333333333334" CenterY="671.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000062825" />
  </DataNode>
  <DataNode TextLabel="Gng8" GraphId="da7b0" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:94235</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG8 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="532.6666666666666" CenterY="707.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000063594" />
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  <DataNode TextLabel="Rxfp2" GraphId="db337" Type="GeneProduct" GroupRef="ca8b3">
    <Comment Source="GenMAPP remarks">PMID: 11809971 LGR8 MOUSE</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:122042</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="LGR8 | leucine-rich repeat-containing G protein..." />
    <Graphics CenterX="96.66666666666667" CenterY="170.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000053368" />
  </DataNode>
  <DataNode TextLabel="Gnb4" GraphId="dccd3" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59345</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB4 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="406.66666666666663" CenterY="747.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027669" />
  </DataNode>
  <DataNode TextLabel="Prkar1b" GraphId="dd475" Type="GeneProduct" GroupRef="cb90f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5575</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKAR1B | protein kinase cAMP-dependent regul..." />
    <Graphics CenterX="227.33333333333331" CenterY="472.0" Width="71.16953333333332" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025855" />
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  <DataNode TextLabel="Rgs19" GraphId="de5c1" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10287</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS19 | regulator of G-protein signalling 19" />
    <Graphics CenterX="1258.6666666666663" CenterY="273.0000000000001" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000002458" />
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  <DataNode TextLabel="ADP" GraphId="def10" Type="Metabolite">
    <Graphics CenterX="938.0" CenterY="564.0" Width="33.333333333333336" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="58-64-0" />
  </DataNode>
  <DataNode TextLabel="Actb" GraphId="df201" Type="GeneProduct" GroupRef="b38f8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:60</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACTB | actin beta" />
    <Graphics CenterX="643.3333333333334" CenterY="631.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029580" />
  </DataNode>
  <DataNode TextLabel="Corin" GraphId="e04fa" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">MGI:97367</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10699</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CORIN | corin serine protease" />
    <Graphics CenterX="420.0" CenterY="102.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000005220" />
  </DataNode>
  <DataNode TextLabel="Gabpb1" GraphId="e0c43" Type="GeneProduct" GroupRef="e5925">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2553</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GABPB2 | GA binding protein transcription facto..." />
    <Graphics CenterX="683.6666666666671" CenterY="903.6666666666671" Width="60.85014666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027361" />
  </DataNode>
  <DataNode TextLabel="Prkcd" GraphId="e1522" Type="GeneProduct" GroupRef="ff3b9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5580</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCD | protein kinase C delta" />
    <Graphics CenterX="1191.9999999999998" CenterY="386.92517006802734" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021948" />
  </DataNode>
  <DataNode TextLabel="Sp1" GraphId="e15f2" Type="GeneProduct" GroupRef="ab773">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6667</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SP1 | Sp1 transcription factor" />
    <Graphics CenterX="786.0000000000005" CenterY="822.6666666666671" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000001280" />
  </DataNode>
  <DataNode TextLabel="Gabpa" GraphId="e2a34" Type="GeneProduct" GroupRef="e5925">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2551</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GABPA | GA binding protein transcription factor..." />
    <Graphics CenterX="683.6666666666671" CenterY="883.6666666666671" Width="60.85014666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000008976" />
  </DataNode>
  <DataNode TextLabel="Adcy6" GraphId="e2cd8" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:112</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY6 | adenylate cyclase 6" />
    <Graphics CenterX="318.66666666666663" CenterY="692.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022994" />
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  <DataNode TextLabel="Guca2a" GraphId="e38cf" Type="GeneProduct" GroupRef="f0a9f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2980</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GUCA2A | guanylate cyclase activator 2A (guanyl..." />
    <Graphics CenterX="523.3333333333334" CenterY="100.0" Width="60.85014666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000023247" />
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  <DataNode TextLabel="Itpr1" GraphId="e3f4b" Type="GeneProduct" GroupRef="a15ef">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3708</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITPR1 | inositol 145-triphosphate receptor t..." />
    <Graphics CenterX="646.3333333333333" CenterY="304.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000030102" />
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  <DataNode TextLabel="Camk2b" GraphId="e501a" Type="GeneProduct" GroupRef="da70b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:816</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2B | calcium/calmodulin-dependent protein k..." />
    <Graphics CenterX="1175.9999999999998" CenterY="630.0" Width="65.23876666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000057897" />
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  <DataNode TextLabel="Crhr1" GraphId="e52b6" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1394</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CRHR1 | corticotropin releasing hormone recepto..." />
    <Graphics CenterX="330.0" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018634" />
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  <DataNode TextLabel="Rln1" GraphId="e56e3" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6013</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RLN1 | relaxin 1" />
    <Graphics CenterX="96.66666666666667" CenterY="102.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000039097" />
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  <DataNode TextLabel="Pde4d" GraphId="e5714" Type="GeneProduct" GroupRef="edaa9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5144</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PDE4D | phosphodiesterase 4D cAMP-specific (ph..." />
    <Graphics CenterX="72.33333333333334" CenterY="380.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021699" />
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  <DataNode TextLabel="Grk6" GraphId="e67cb" Type="GeneProduct" GroupRef="b01f5">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2870</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRK6 | G protein-coupled receptor kinase 6" />
    <Graphics CenterX="92.33333333333326" CenterY="246.66666666666663" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000074886" />
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  <DataNode TextLabel="Ets2" GraphId="e7514" Type="GeneProduct" GroupRef="ab773">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2114</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ETS2 | v-ets erythroblastosis virus E26 oncogen..." />
    <Graphics CenterX="786.0000000000005" CenterY="782.6666666666671" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022895" />
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  <DataNode TextLabel="Atf3" GraphId="e780b" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:467</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATF3 | activating transcription factor 3" />
    <Graphics CenterX="63.0" CenterY="612.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000026628" />
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  <DataNode TextLabel="Adcy4" GraphId="e7e21" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">There is no SwissProt entry for a full-length sequence in mouse.  This EST is from the Affymetrix Murine6500 chip.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:196883</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY4 | adenylate cyclase 4" />
    <Graphics CenterX="250.0" CenterY="752.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022220" />
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  <DataNode TextLabel="Plcd1" GraphId="e84a9" Type="GeneProduct" GroupRef="f2693">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5333</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCD1 | phospholipase C delta 1" />
    <Graphics CenterX="1271.9999999999998" CenterY="630.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000010660" />
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  <DataNode TextLabel="Rgs4" GraphId="e86c9" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5999</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS4 | regulator of G-protein signalling 4" />
    <Graphics CenterX="1183.9999999999998" CenterY="213.00000000000034" Width="60.0" Height="20.00000000000003" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038530" />
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  <DataNode TextLabel="Rgs14" GraphId="e962f" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10636</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS14 | regulator of G-protein signalling 14" />
    <Graphics CenterX="1258.6666666666663" CenterY="193.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000052087" />
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  <DataNode TextLabel="Slc8a1" GraphId="e9971" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6546</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SLC8A1 | solute carrier family 8 (sodium/calciu..." />
    <Graphics CenterX="1061.0" CenterY="162.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000054640" />
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  <DataNode TextLabel="Guca2b" GraphId="ea7ba" Type="GeneProduct" GroupRef="f0a9f">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2981</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GUCA2B | guanylate cyclase activator 2B (urogua..." />
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  <DataNode TextLabel="Arrb1" GraphId="eb47a" Type="GeneProduct" GroupRef="b01f5">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:408</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB1 | arrestin beta 1" />
    <Graphics CenterX="92.33333333333326" CenterY="266.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018909" />
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  <DataNode TextLabel="Gja1" GraphId="ebcb9" Type="GeneProduct" GroupRef="e60e9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2697</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GJA1 | gap junction protein alpha 1 43kDa (co..." />
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  <DataNode TextLabel="Arrb1" GraphId="ec135" Type="GeneProduct" GroupRef="e2890">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:408</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB1 | arrestin beta 1" />
    <Graphics CenterX="899.3333333333333" CenterY="198.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018909" />
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  <DataNode TextLabel="Ywhag" GraphId="eca01" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7532</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAG | tyrosine 3-monooxygenase/tryptophan 5-m..." />
    <Graphics CenterX="1195.9999999999998" CenterY="546.6666666666665" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000051391" />
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  <DataNode TextLabel="Cacnb3" GraphId="ed286" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:784</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CACNB3 | calcium channel voltage-dependent be..." />
    <Graphics CenterX="981.6666666666666" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000003352" />
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  <DataNode TextLabel="Ackr3" GraphId="ed3c1" Type="GeneProduct" GroupRef="aa636">
    <Comment Source="GenMAPP remarks">PMID: 10614663</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:57007</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CMKOR1 | chemokine orphan receptor 1" />
    <Graphics CenterX="173.33333333333334" CenterY="170.0" Width="65.23876666666666" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000044337" />
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  <DataNode TextLabel="Igfbp1" GraphId="ee38a" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3484</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGFBP1 | insulin-like growth factor binding pro..." />
    <Graphics CenterX="160.0" CenterY="692.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020429" />
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  <DataNode TextLabel="Pkig" GraphId="eeee6" Type="GeneProduct" GroupRef="b262c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11142</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PKIG | protein kinase (cAMP-dependent catalyti..." />
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  <DataNode TextLabel="Pde4b" GraphId="eefb4" Type="GeneProduct" GroupRef="edaa9">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5142</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PDE4B | phosphodiesterase 4B cAMP-specific (ph..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000028525" />
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  <DataNode TextLabel="Gngt1" GraphId="ef0ed" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2792</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNGT1 | guanine nucleotide binding protein (G p..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000029663" />
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  <DataNode TextLabel="Pkia" GraphId="f11bd" Type="GeneProduct" GroupRef="b262c">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5569</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PKIA | protein kinase (cAMP-dependent catalyti..." />
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  <DataNode TextLabel="Ywhaq" GraphId="f12df" Type="GeneProduct" GroupRef="a9e43">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10971</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-m..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000076432" />
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  <DataNode TextLabel="Cyclic GMP" GraphId="f43ae" Type="Metabolite">
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    <Xref Database="HMDB" ID="HMDB0001314" />
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  <DataNode TextLabel="Creb3" GraphId="f4dd8" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10488</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CREB3 | cAMP responsive element binding protein..." />
    <Graphics CenterX="132.33333333333331" CenterY="592.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000028466" />
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  <DataNode TextLabel="Actc1" GraphId="f4f84" Type="GeneProduct" GroupRef="b38f8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:70</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACTC | actin alpha cardiac muscle" />
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  <DataNode TextLabel="ADP" GraphId="f545b" Type="Metabolite">
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    <Xref Database="CAS" ID="58-64-0" />
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  <DataNode TextLabel="Igfbp3" GraphId="f6872" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">Relaxin is a member of the Insulin Growth Factor family of proteins.  IGFBP-3 binds IGFII preferentially. (SwissProt).</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3486</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IGFBP3 | insulin-like growth factor binding pro..." />
    <Graphics CenterX="160.0" CenterY="732.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000020427" />
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  <DataNode TextLabel="Plcg1" GraphId="f6ab9" Type="GeneProduct" GroupRef="f2693">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5335</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCG1 | phospholipase C gamma 1" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000016933" />
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  <DataNode TextLabel="Gnas" GraphId="f6b05" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2778</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAS | GNAS complex locus" />
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  <DataNode TextLabel="Maff" GraphId="f6b0e" Type="GeneProduct" GroupRef="c509b">
    <Comment Source="GenMAPP remarks">OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:23764</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAFF | v-maf musculoaponeurotic fibrosarcoma on..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000042622" />
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  <DataNode TextLabel="PRKACA" GraphId="f71ef" Type="GeneProduct" GroupRef="cb90f">
    <Comment Source="HomologyMapper">No homologues found for original id L:5566</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKACA | protein kinase cAMP-dependent cataly..." />
    <Graphics CenterX="227.33333333333331" CenterY="532.0" Width="71.16953333333332" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="" ID="" />
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  <DataNode TextLabel="Calm3" GraphId="f76a2" Type="GeneProduct" GroupRef="ac6cc">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:808</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALM3 | calmodulin 3 (phosphorylase kinase del..." />
    <Graphics CenterX="813.3333333333333" CenterY="475.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000019370" />
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  <DataNode TextLabel="Atf2" GraphId="f86c8" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1386</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATF2 | activating transcription factor 2" />
    <Graphics CenterX="63.0" CenterY="592.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000027104" />
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  <DataNode TextLabel="Gng4" GraphId="f9223" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2786</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNG4 | guanine nucleotide binding protein (G pr..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000021303" />
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  <DataNode TextLabel="CALM2" GraphId="f9e16" Type="GeneProduct" GroupRef="ac6cc">
    <Comment Source="HomologyMapper">Multiple homologues found: En:ENSMUSG00000019370;En:ENSMUSG00000019370;</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALM2 | calmodulin 2 (phosphorylase kinase del..." />
    <Graphics CenterX="813.3333333333333" CenterY="455.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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  <DataNode TextLabel="Adcy9" GraphId="f9e74" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:115</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ADCY9 | adenylate cyclase 9" />
    <Graphics CenterX="318.66666666666663" CenterY="752.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000005580" />
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  <DataNode TextLabel="CALM1" GraphId="f9fd8" Type="GeneProduct" GroupRef="ac6cc">
    <Comment Source="HomologyMapper">No homologues found for original id L:801</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALM1 | calmodulin 1 (phosphorylase kinase del..." />
    <Graphics CenterX="813.3333333333333" CenterY="435.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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  <DataNode TextLabel="Acta1" GraphId="fa3cd" Type="GeneProduct" GroupRef="b38f8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:58</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACTA1 | actin alpha 1 skeletal muscle" />
    <Graphics CenterX="643.3333333333334" CenterY="591.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031972" />
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  <DataNode TextLabel="Gnb1" GraphId="fa742" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2782</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNB1 | guanine nucleotide binding protein (G pr..." />
    <Graphics CenterX="406.66666666666663" CenterY="687.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000029064" />
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  <DataNode TextLabel="Myl2" GraphId="faa5d" Type="GeneProduct" GroupRef="e8d60">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4633</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYL2 | myosin light polypeptide 2 regulatory..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000013936" />
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  <DataNode TextLabel="Rgs3" GraphId="fae78" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5998</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RGS3 | regulator of G-protein signalling 3" />
    <Graphics CenterX="1183.9999999999998" CenterY="193.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000059810" />
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  <DataNode TextLabel="Itpr2" GraphId="fb14e" Type="GeneProduct" GroupRef="a15ef">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3709</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ITPR2 | inositol 145-triphosphate receptor t..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000030287" />
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  <DataNode TextLabel="Plcb3" GraphId="fb3ea" Type="GeneProduct" GroupRef="f2693">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCB3 | phospholipase C beta 3 (phosphatidylin..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000024960" />
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  <DataNode TextLabel="ATP" GraphId="fc33b" Type="Metabolite">
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    <Xref Database="CAS" ID="1927-31-7" />
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  <DataNode TextLabel="Camk2a" GraphId="fcddf" Type="GeneProduct" GroupRef="da70b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:815</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CAMK2A | calcium/calmodulin-dependent protein k..." />
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  <DataNode TextLabel="Nfkb1" GraphId="fd09c" Type="GeneProduct" GroupRef="ab773">
    <Comment Source="GenMAPP remarks">Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKB1 | nuclear factor of kappa light polypepti..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000028163" />
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    <Xref Database="HMDB" ID="HMDB0000058" />
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  <DataNode TextLabel="Creb1" GraphId="fe4d9" Type="GeneProduct" GroupRef="d37aa">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1385</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CREB1 | cAMP responsive element binding protein..." />
    <Graphics CenterX="132.33333333333331" CenterY="572.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000025958" />
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  <DataNode TextLabel="Gucy1a3" GraphId="ff2d6" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">PMID: 11854458</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2982</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GUCY1A3 | guanylate cyclase 1 soluble alpha 3..." />
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