<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Tryptophan metabolism" Data-Source="WikiPathways" Version="WP79_r128037" Author="[L.M.Ferrante, MaintBot, Khanspers, Egonw, Ddigles, AlexanderPico, Fehrhart, Eweitz]" Last-Modified="20240121180027" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway describes the metabolism of tryptophan, an essential amino acid. 
Originally converted from rat to human using ortholog information. Edited by Sebastien Burel</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP465&amp;amp;oldid=30270 WP465(r30270)] with a 57% conversion rate.</Comment>
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  <DataNode TextLabel="4-(2-Aminophenyl)-2,4-dioxobutanoate" GraphId="a05" Type="Metabolite">
    <Comment Source="GenMAPP remarks">4-(2-Aminophenyl)-2,4-dioxobutanoate</Comment>
    <Graphics CenterX="700.0" CenterY="1030.0" Width="221.33333333333334" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:58147" />
  </DataNode>
  <DataNode TextLabel="Indolelactate" GraphId="a09" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Indolelactate</Comment>
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    <Xref Database="PubChem-compound" ID="92904" />
  </DataNode>
  <DataNode TextLabel="2-Aminomuconate" GraphId="a0d" Type="Metabolite">
    <Comment Source="GenMAPP remarks">2-Aminomuconate</Comment>
    <Graphics CenterX="1360.6666666666667" CenterY="1026.6666666666667" Width="109.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="27" />
  </DataNode>
  <DataNode TextLabel="3-Methylindolepyruvate" GraphId="a5f" Type="Metabolite">
    <Comment Source="GenMAPP remarks">3-Methylindolepyruvate</Comment>
    <Graphics CenterX="1071.75" CenterY="435.6666666666667" Width="146.5" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="440740" />
  </DataNode>
  <DataNode TextLabel="7,8-Dihydro-7,8-dihydroxykynurenate" GraphId="a76" Type="Metabolite">
    <Comment Source="GenMAPP remarks">7,8-Dihydro-7,8-dihydroxykynurenate</Comment>
    <Graphics CenterX="570.0" CenterY="1121.3333333333333" Width="213.33333333333334" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="388563" />
  </DataNode>
  <DataNode TextLabel="Indole-3-acetate" GraphId="a96" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Indole-3-acetate</Comment>
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    <Xref Database="Chemspider" ID="780" />
  </DataNode>
  <DataNode TextLabel="N-Methylserotonin" GraphId="a9c" Type="Metabolite">
    <Comment Source="GenMAPP remarks">N-Methylserotonin</Comment>
    <Graphics CenterX="1070.0" CenterY="266.6666666666667" Width="108.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="150885" />
  </DataNode>
  <DataNode TextLabel="C00877" GraphId="aa4" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Crotonoyl-CoA</Comment>
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    <Xref Database="KEGG Compound" ID="C00877" />
  </DataNode>
  <DataNode TextLabel="N-Methyltryptamine" GraphId="ab1" Type="Metabolite">
    <Comment Source="GenMAPP remarks">N-Methyltryptamine</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:28136" />
  </DataNode>
  <DataNode TextLabel="4,8-Dihydroxyquinoline" GraphId="ab4" Type="Metabolite">
    <Comment Source="GenMAPP remarks">4,8-Dihydroxyquinoline</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:28883" />
  </DataNode>
  <DataNode TextLabel="4-(2-Amino-5-hydroxyphenyl)&#xA;-2,4-dioxobutanoate" GraphId="adb" Type="Metabolite">
    <Comment Source="GenMAPP remarks">4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate</Comment>
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    <Xref Database="Chemspider" ID="389617" />
  </DataNode>
  <DataNode TextLabel="Oxaloacetate" GraphId="af2" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Oxaloacetate</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:16452" />
  </DataNode>
  <DataNode TextLabel="3-(2-Aminoethyl)&#xA;-1H-indol-5-ol" GraphId="b11" Type="Metabolite">
    <Comment Source="GenMAPP remarks">3-(2-Aminoethyl)-1H-indol-5-ol</Comment>
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    <Xref Database="PubChem-compound" ID="5202" />
  </DataNode>
  <DataNode TextLabel="Indolepyruvate" GraphId="b23" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Indolepyruvate</Comment>
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    <Xref Database="PubChem-compound" ID="803" />
  </DataNode>
  <DataNode TextLabel="Melatonin" GraphId="b4a" Type="Metabolite">
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    <Xref Database="PubChem-compound" ID="896" />
  </DataNode>
  <DataNode TextLabel="Indole-3-acetaldehyde" GraphId="b4c" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Indole-3-acetaldehyde</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:18086" />
  </DataNode>
  <DataNode TextLabel="Glucobrassicin" GraphId="b73" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Glucobrassicin</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:29028" />
  </DataNode>
  <DataNode TextLabel="Kynurenate" GraphId="b7e" Type="Metabolite">
    <Comment Source="GenMAPP remarks">4-Hydroxy-2-quinolinecarboxylic</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:18344" />
  </DataNode>
  <DataNode TextLabel="C00527" GraphId="b88" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Glutaryl-CoA</Comment>
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    <Xref Database="KEGG Compound" ID="C00527" />
  </DataNode>
  <DataNode TextLabel="Formylanthranilate" GraphId="b89" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Formylanthranilate</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:18410" />
  </DataNode>
  <DataNode TextLabel="3-Hydroxy-&#xA;L-kynurenine" GraphId="bb4" Type="Metabolite">
    <Comment Source="GenMAPP remarks">3-Hydroxy-L-kynurenine</Comment>
    <Graphics CenterX="980.0" CenterY="945.9166666666666" Width="66.33333333333333" Height="22.166666666666668" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:17380" />
  </DataNode>
  <DataNode TextLabel="5-Methoxyindoleacetate" GraphId="bbc" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-Methoxyindoleacetate</Comment>
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    <Xref Database="PubChem-compound" ID="18986" />
  </DataNode>
  <DataNode TextLabel="3-Methyldioxyindole" GraphId="be5" Type="Metabolite">
    <Graphics CenterX="1468.6666666666667" CenterY="474.6666666666667" Width="91.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:28254" />
  </DataNode>
  <DataNode TextLabel="2-Aminomuconate" GraphId="bfd" Type="Metabolite">
    <Comment Source="GenMAPP remarks">2-Aminomuconate</Comment>
    <Graphics CenterX="1348.0" CenterY="1123.3333333333333" Width="110.0" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="27" />
  </DataNode>
  <DataNode TextLabel="C01144" GraphId="c64" Type="Metabolite">
    <Comment Source="GenMAPP remarks">(S)-3-Hydroxybutanoyl-CoA</Comment>
    <Graphics CenterX="910.0" CenterY="1213.3333333333333" Width="48.333333333333336" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="KEGG Compound" ID="C01144" />
  </DataNode>
  <DataNode TextLabel="5-Hydroxyindoleacetaldehyde" GraphId="c6a" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-Hydroxyindoleacetaldehyde</Comment>
    <Graphics CenterX="855.5833333333334" CenterY="105.58333333333334" Width="171.16666666666674" Height="18.833333333333314" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="74688" />
  </DataNode>
  <DataNode TextLabel="3-Hydroxyanthranilate" GraphId="c7d" Type="Metabolite">
    <Comment Source="GenMAPP remarks">3-Hydroxyanthranilate</Comment>
    <Graphics CenterX="1134.25" CenterY="944.3333333333334" Width="105.5" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="7822291" />
  </DataNode>
  <DataNode TextLabel="Indole-3-acetaldoxime" GraphId="c94" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Indole-3-acetaldoxime</Comment>
    <Graphics CenterX="1434.1666666666667" CenterY="733.3333333333334" Width="102.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:28311" />
  </DataNode>
  <DataNode TextLabel="5-Hydroxy-N-formylkynurenine" GraphId="cac" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-Hydroxy-N-formylkynurenine</Comment>
    <Graphics CenterX="740.5" CenterY="191.0" Width="181.0" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="389615" />
  </DataNode>
  <DataNode TextLabel="Isophenoxazine" GraphId="cea" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Isophenoxazine</Comment>
    <Graphics CenterX="1384.0833333333333" CenterY="860.0" Width="72.16666666666667" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="65565" />
  </DataNode>
  <DataNode TextLabel="5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate" GraphId="cfc" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate</Comment>
    <Graphics CenterX="163.33333333333334" CenterY="892.3333333333334" Width="247.33333333333334" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="389619" />
  </DataNode>
  <DataNode TextLabel="Indole-3-ethanol" GraphId="d49" Type="Metabolite">
    <Graphics CenterX="943.3333333333334" CenterY="476.6666666666667" Width="96.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="10685" />
  </DataNode>
  <DataNode TextLabel="6-Hydroxyindolelactate" GraphId="d72" Type="Metabolite">
    <Comment Source="GenMAPP remarks">6-Hydroxyindolelactate</Comment>
    <Graphics CenterX="1242.3333333333333" CenterY="406.6666666666667" Width="153.33333333333348" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:27524" />
  </DataNode>
  <DataNode TextLabel="Anthranilate" GraphId="d90" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Anthranilate</Comment>
    <Graphics CenterX="366.6666666666667" CenterY="703.3333333333334" Width="74.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:16567" />
  </DataNode>
  <DataNode TextLabel="5-Hydroxykynurenamine" GraphId="d9a" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-Hydroxykynurenamine</Comment>
    <Graphics CenterX="357.5" CenterY="242.33333333333334" Width="143.0" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="144400" />
  </DataNode>
  <DataNode TextLabel="Anthranilate" GraphId="da3" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Anthranilate</Comment>
    <Graphics CenterX="1563.3333333333333" CenterY="513.3333333333334" Width="74.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:16567" />
  </DataNode>
  <DataNode TextLabel="5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolin" GraphId="dac" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate</Comment>
    <Graphics CenterX="276.6666666666667" CenterY="1127.3333333333333" Width="290.3333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="2-Formylaminobenzaldehyde" GraphId="db8" Type="Metabolite">
    <Graphics CenterX="530.0" CenterY="463.3333333333333" Width="167.33333333333334" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:18033" />
  </DataNode>
  <DataNode TextLabel="2-Formamino&#xA;benzoylacetate" GraphId="db9" Type="Metabolite">
    <Comment Source="GenMAPP remarks">2-Formaminobenzoylacetate</Comment>
    <Graphics CenterX="1464.6666666666667" CenterY="512.9166666666666" Width="80.33333333333333" Height="22.166666666666668" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="4,6-Dihydroxyquinoline" GraphId="dda" Type="Metabolite">
    <Comment Source="GenMAPP remarks">4,6-Dihydroxyquinoline</Comment>
    <Graphics CenterX="117.66666666666666" CenterY="243.33333333333334" Width="141.33333333333331" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="389609" />
  </DataNode>
  <DataNode TextLabel="L-Tryptophanyl-tRNA" GraphId="dec">
    <Graphics CenterX="803.3333333333334" CenterY="403.3333333333333" Width="121.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="2,3-Dihydroxyindole" GraphId="df7" Type="Metabolite">
    <Graphics CenterX="334.0" CenterY="513.3333333333334" Width="116.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:17828" />
  </DataNode>
  <DataNode TextLabel="Quinolinate" GraphId="e1b" Type="Metabolite">
    <Graphics CenterX="1380.0" CenterY="906.6666666666666" Width="69.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="2777129" />
  </DataNode>
  <DataNode TextLabel="Cinnavalininate" GraphId="e22" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Cinnavalininate</Comment>
    <Graphics CenterX="1227.3333333333333" CenterY="786.6666666666666" Width="74.66666666666667" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="102864" />
  </DataNode>
  <DataNode TextLabel="5-Hydroxy-&#xA;L-tryptophan" GraphId="e51" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-Hydroxy-L-tryptophan</Comment>
    <Graphics CenterX="695.5" CenterY="322.0" Width="77.0" Height="40.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:17780" />
  </DataNode>
  <DataNode TextLabel="3-Hydroxykynurenamine" GraphId="e6a" Type="Metabolite">
    <Comment Source="GenMAPP remarks">3-Hydroxykynurenamine</Comment>
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    <Xref Database="Chemspider" ID="144400" />
  </DataNode>
  <DataNode TextLabel="Formyl-5-hydroxykynurenamine" GraphId="e73" Type="Metabolite">
    <Graphics CenterX="1106.6666666666667" CenterY="223.33333333333334" Width="184.33333333333334" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="440743" />
  </DataNode>
  <DataNode TextLabel="5-Hydroxyindolepyruvate" GraphId="e76" Type="Metabolite">
    <Graphics CenterX="472.0" CenterY="321.6666666666667" Width="150.0" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="389613" />
  </DataNode>
  <DataNode TextLabel="3-Methoxyanthranilate" GraphId="e79" Type="Metabolite">
    <Comment Source="GenMAPP remarks">3-Methoxyanthranilate</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:20109" />
  </DataNode>
  <DataNode TextLabel="2-Oxoglutarate" GraphId="e9f" Type="Metabolite">
    <Comment Source="GenMAPP remarks">2-Oxoglutarate</Comment>
    <Graphics CenterX="140.0" CenterY="780.0" Width="90.33333333333333" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:30916" />
  </DataNode>
  <DataNode TextLabel="N-Acetylindoxyl" GraphId="eb4" Type="Metabolite">
    <Comment Source="GenMAPP remarks">N-Acetylindoxyl</Comment>
    <Graphics CenterX="291.25" CenterY="377.08333333333337" Width="100.5" Height="16.166666666666742" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:15363" />
  </DataNode>
  <DataNode TextLabel="2-Oxoadipate" GraphId="ec1" Type="Metabolite">
    <Comment Source="GenMAPP remarks">2-Oxoadipate</Comment>
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    <Xref Database="Chemspider" ID="70" />
  </DataNode>
  <DataNode TextLabel="7,8-Dihydroxykynurenate" GraphId="ec4" Type="Metabolite">
    <Comment Source="GenMAPP remarks">7,8-Dihydroxykynurenate</Comment>
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    <Xref Database="ChEBI" ID="CHEBI:58171" />
  </DataNode>
  <DataNode TextLabel="Xanthurenic" GraphId="ec9" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Xanthurenic</Comment>
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    <Xref Database="Chemspider" ID="5497" />
  </DataNode>
  <DataNode TextLabel="5-Hydroxyindoleacetate" GraphId="ed2" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-Hydroxyindoleacetate</Comment>
    <Graphics CenterX="1070.5" CenterY="106.66666666666667" Width="143.0" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="PubChem-compound" ID="1826" />
  </DataNode>
  <DataNode TextLabel="C00332" GraphId="efd" Type="Metabolite">
    <Comment Source="GenMAPP remarks">Acetoacetyl-CoA</Comment>
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    <Xref Database="KEGG Compound" ID="C00332" />
  </DataNode>
  <DataNode TextLabel="5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate" GraphId="f00" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate</Comment>
    <Graphics CenterX="159.0" CenterY="1048.0" Width="159.33333333333334" Height="26.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="Chemspider" ID="389620" />
  </DataNode>
  <DataNode TextLabel="(Z)-5-Oxohex-2-enedioate" GraphId="f44" Type="Metabolite">
    <Comment Source="GenMAPP remarks">(Z)-5-Oxohex-2-enedioate</Comment>
    <Graphics CenterX="1549.75" CenterY="1123.3333333333333" Width="145.0" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
    <Xref Database="ChEBI" ID="CHEBI:16967" />
  </DataNode>
  <DataNode TextLabel="5-(2'-Formylethyl)-4,6-dihydroxypicolinate" GraphId="f5a" Type="Metabolite">
    <Comment Source="GenMAPP remarks">5-(2'-Formylethyl)-4,6-dihydroxypicolinate</Comment>
    <Graphics CenterX="160.0" CenterY="992.3333333333334" Width="238.33333333333334" Height="15.0" ZOrder="28672" FontSize="12" Valign="Middle" />
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