<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Sphingolipid metabolism overview" Data-Source="WikiPathways" Version="WP4344_r139559" Author="[DeSl, Egonw, MaintBot, Eweitz]" Last-Modified="20250621070517" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway is inspired by the Lipidmaps&gt;Sphingolipids pathway [ [1] ](https://lipidmaps.org/pathway/pathways_maps).
Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules.
This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier.
The integrated pathway can be found [here](https://www.wikipathways.org/index.php/Pathway:WP4690).</Comment>
  <BiopaxRef>fc1</BiopaxRef>
  <Graphics BoardWidth="1421.0930551543727" BoardHeight="831.0226147461126" />
  <DataNode TextLabel="ATP" GraphId="a01f7" Type="Metabolite">
    <Graphics CenterX="355.3947368421049" CenterY="512.6315789473686" Width="59.73684210526337" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:30616" />
  </DataNode>
  <DataNode TextLabel="3-keto-sphinganine" GraphId="a3300" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="260.52538196607225" CenterY="333.75" Width="117.5" Height="46.5" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP01020002" />
  </DataNode>
  <DataNode TextLabel="Ppap2a" GraphId="a9de8" Type="Protein" GroupRef="e29dc">
    <Graphics CenterX="899.1484758460344" CenterY="545.4711673699013" Width="63.0" Height="23.5" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="19012" />
  </DataNode>
  <DataNode TextLabel="Cerk" GraphId="ac40d" Type="Protein">
    <Graphics CenterX="465.9159724830165" CenterY="363.12483631601896" Width="82.5" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="223753" />
  </DataNode>
  <DataNode TextLabel="Sgpp1" GraphId="b2311" Type="Protein" GroupRef="ba605">
    <Graphics CenterX="118.9473684210526" CenterY="532.6315789473686" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9JI99" />
  </DataNode>
  <DataNode TextLabel="Asah1" GraphId="b614f" Type="Protein">
    <Graphics CenterX="693.6228077728985" CenterY="470.25879043600634" Width="73.13642756680707" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9WV54" />
  </DataNode>
  <DataNode TextLabel="Palmitoyl-CoA" GraphId="b7caa" Type="Metabolite">
    <Comment>aka CoA(16:0)</Comment>
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="260.0253819660725" CenterY="109.75" Width="98.5" Height="34.5" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA07050360" />
  </DataNode>
  <DataNode TextLabel="Sgms1" GraphId="b96e1" Type="Protein" GroupRef="d945f">
    <Graphics CenterX="1129.4371712493132" CenterY="299.6802218777807" Width="79.5" Height="21.5" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="208449" />
  </DataNode>
  <DataNode TextLabel="Sphk2" GraphId="b9b00" Type="Protein" GroupRef="e505a">
    <Graphics CenterX="516.0102901920261" CenterY="552.7694559707356" Width="90.0" Height="20.791338582677554" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9JIA7" />
  </DataNode>
  <DataNode TextLabel="Sgpl1" GraphId="bd74a" Type="Protein">
    <Graphics CenterX="514.603820431126" CenterY="667.9746835443043" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20397" />
  </DataNode>
  <DataNode TextLabel="Ugcg" GraphId="c268f" Type="Protein">
    <Graphics CenterX="520.2012611034355" CenterY="314.9253731343285" Width="64.5" Height="23.880597014925385" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22234" />
  </DataNode>
  <DataNode TextLabel="Serine" GraphId="c3e72" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="398.02538196606986" CenterY="113.58333333333334" Width="110.5" Height="33.49999999999999" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="PubChem-compound" ID="5951" />
  </DataNode>
  <DataNode TextLabel="Hexadecanal" GraphId="d0961" Type="Metabolite">
    <Graphics CenterX="257.8689122051721" CenterY="732.755274261604" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA06000088" />
  </DataNode>
  <DataNode TextLabel="Sptlc1" GraphId="d5e45" Type="Protein" GroupRef="f0511">
    <Graphics CenterX="115.6455370048315" CenterY="188.0503875968994" Width="112.5" Height="26.333333333333705" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="268656" />
  </DataNode>
  <DataNode TextLabel="Sphk1" GraphId="d6dbc" Type="Protein" GroupRef="e505a">
    <Graphics CenterX="516.0102901920261" CenterY="531.7445215875338" Width="90.0" Height="21.25853018372678" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8CI15" />
  </DataNode>
  <DataNode TextLabel="Degs1" GraphId="d7335" Type="Protein" GroupRef="c0c64">
    <Graphics CenterX="699.9210465305932" CenterY="296.80000982049467" Width="62.5" Height="18.5" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13244" />
  </DataNode>
  <DataNode TextLabel="Kdsr" GraphId="de6f3" Type="Protein">
    <Graphics CenterX="115.6455370048315" CenterY="399.08333333333337" Width="102.5" Height="23.833333333333307" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q6GV12" />
  </DataNode>
  <DataNode TextLabel="Sptlc2" GraphId="e40f3" Type="Protein" GroupRef="f0511">
    <Graphics CenterX="115.6455370048315" CenterY="213.8003875968989" Width="112.75" Height="25.166666666665265" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P97363" />
  </DataNode>
  <DataNode TextLabel="Ethanolamine-phosphate" GraphId="f4ce4" Type="Metabolite">
    <Graphics CenterX="515.512911340217" CenterY="732.7552742616041" Width="151.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="PubChem-compound" ID="1015" />
  </DataNode>
  <DataNode TextLabel="H₂O" GraphId="f7997" Type="Metabolite">
    <Graphics CenterX="123.28947368421055" CenterY="597.8947368421047" Width="54.4736842105263" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:15377" />
  </DataNode>
  <DataNode TextLabel="Sphingosine" GraphId="f88b3" Type="Metabolite">
    <Graphics CenterX="760.0531875197355" CenterY="510.78938115330516" Width="160.66666666666657" Height="24.999999999999968" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP01010001" />
  </DataNode>
  <DataNode TextLabel="Sphinganine" GraphId="ed964" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="259.45224553850534" CenterY="477.03410689170175" Width="160.66666666666663" Height="28.49999999999999" ZOrder="32769" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP01020001" />
  </DataNode>
  <DataNode TextLabel="Sphinganine-1-phosphate" GraphId="f368e" Type="Metabolite">
    <Graphics CenterX="259.2753819660722" CenterY="614.4644866385379" Width="160.66666666666663" Height="31.833333333333485" ZOrder="32770" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP01050002" />
  </DataNode>
  <DataNode TextLabel="DH-Ceramide" GraphId="c997e" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="761.4596572806357" CenterY="214.56293952180025" Width="117.5" Height="28.5" ZOrder="32771" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020000" />
  </DataNode>
  <DataNode TextLabel="CerS4" GraphId="f4e24" Type="Protein" GroupRef="d4bdd">
    <Graphics CenterX="1231.4917804137633" CenterY="294.50166442479895" Width="52.95614268548025" Height="25.0" ZOrder="32772" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67260" />
  </DataNode>
  <DataNode TextLabel="CerS5" GraphId="c24ce" Type="Protein" GroupRef="fa178">
    <Graphics CenterX="1225.1737236809508" CenterY="115.90094220193114" Width="52.95614268548025" Height="25.0" ZOrder="32773" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67260" />
  </DataNode>
  <DataNode TextLabel="CerS6" GraphId="e4848" Type="Protein" GroupRef="fa178">
    <Graphics CenterX="1225.1737236809508" CenterY="140.90094220193134" Width="52.95614268548025" Height="25.0" ZOrder="32774" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="241447" />
  </DataNode>
  <DataNode TextLabel="Ceramide" GraphId="bf530" Type="Metabolite">
    <BiopaxRef>b6c</BiopaxRef>
    <Graphics CenterX="761.4596572806357" CenterY="396.75" Width="117.5" Height="28.5" ZOrder="32775" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02010000" />
  </DataNode>
  <DataNode TextLabel="Cer-1-P" GraphId="dea07" Type="Metabolite">
    <Graphics CenterX="605.4406013383634" CenterY="485.8342733197027" Width="87.99702178113748" Height="28.500000000000032" ZOrder="32776" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02050000" />
  </DataNode>
  <DataNode TextLabel="DH-Cer-1-P" GraphId="cc25d" Type="Metabolite">
    <Graphics CenterX="602.4406013383634" CenterY="179.4629629629628" Width="87.99702178113748" Height="28.500000000000007" ZOrder="32777" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP020500A0" />
  </DataNode>
  <DataNode TextLabel="SM" GraphId="e9d8d" Type="Metabolite">
    <Graphics CenterX="1046.5971396997593" CenterY="396.75" Width="117.5" Height="28.5" ZOrder="32778" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0301" />
  </DataNode>
  <DataNode TextLabel="Glc-Cer" GraphId="d60ba" Type="Metabolite">
    <Graphics CenterX="605.4406013383634" CenterY="352.6465376849662" Width="87.99702178113748" Height="28.499999999999982" ZOrder="32779" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AA00" />
  </DataNode>
  <DataNode TextLabel="DH-SM" GraphId="ba26f" Type="Metabolite">
    <Graphics CenterX="1044.5971396997593" CenterY="214.56293952180027" Width="117.5" Height="28.5" ZOrder="32780" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP030100A0" />
  </DataNode>
  <DataNode TextLabel="DH-Glc-Cer" GraphId="e6a32" Type="Metabolite">
    <Graphics CenterX="594.2465714876168" CenterY="279.1860143725812" Width="87.99702178113742" Height="28.5" ZOrder="32781" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="Gal-Cer" GraphId="be1a4" Type="Metabolite">
    <Graphics CenterX="843.0526860313873" CenterY="329.6037792363389" Width="117.5" Height="28.5" ZOrder="32782" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP0501AC00" />
  </DataNode>
  <DataNode TextLabel="DH-Gal-Cer" GraphId="c9f6c" Type="Metabolite">
    <Graphics CenterX="843.0526860313873" CenterY="295.22933270823546" Width="117.5" Height="28.5" ZOrder="32783" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="" />
  </DataNode>
  <DataNode TextLabel="Smpd1" GraphId="fe827" Type="Protein">
    <Graphics CenterX="1034.813102141074" CenterY="311.0669014084507" Width="79.5" Height="21.5" ZOrder="32785" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20597" />
  </DataNode>
  <DataNode TextLabel="Degs2" GraphId="b3147" Type="Protein" GroupRef="c0c64">
    <Graphics CenterX="699.9210465305932" CenterY="315.3000098204946" Width="62.5" Height="18.5" ZOrder="32786" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="70059" />
  </DataNode>
  <DataNode TextLabel="Sgms2" GraphId="efc57" Type="Protein" GroupRef="d945f">
    <Graphics CenterX="1129.4371712493132" CenterY="320.6802218777803" Width="79.5" Height="21.5" ZOrder="32787" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="74442" />
  </DataNode>
  <DataNode TextLabel="Sphingosine-1-phosphate" GraphId="b32ff" Type="Metabolite">
    <Graphics CenterX="760.0531875197412" CenterY="614.4644866385379" Width="160.66666666666663" Height="31.833333333333485" ZOrder="32788" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP01050001" />
  </DataNode>
  <DataNode TextLabel="1-Hexadecenal" GraphId="ba579" Type="Metabolite">
    <Graphics CenterX="760.0531875197355" CenterY="732.755274261604" Width="90.0" Height="25.0" ZOrder="32789" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA06000088" />
  </DataNode>
  <DataNode TextLabel="Ppap2b" GraphId="a5a0a" Type="Protein" GroupRef="e29dc">
    <Graphics CenterX="899.1484758460344" CenterY="568.2211673699013" Width="63.0" Height="23.5" ZOrder="32790" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67916" />
  </DataNode>
  <DataNode TextLabel="Ppap2c" GraphId="c0dd9" Type="Protein" GroupRef="e29dc">
    <Graphics CenterX="899.1484758460344" CenterY="591.7211673699013" Width="63.0" Height="23.5" ZOrder="32791" FontSize="12" Valign="Middle" />
    <Xref Database="NCBI Protein" ID="50784" />
  </DataNode>
  <DataNode TextLabel="CoA(16:0)" GraphId="f11ea" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="715.7552118446347" CenterY="36.96117249737806" Width="90.0" Height="25.0" ZOrder="32792" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA07050360" />
  </DataNode>
  <DataNode TextLabel="Ugt8a" GraphId="cbfa3" Type="Protein">
    <Graphics CenterX="944.6777512536523" CenterY="310.2239903975606" Width="64.5" Height="20.0" ZOrder="32795" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22239" />
  </DataNode>
  <DataNode TextLabel="CoA(18:0)" GraphId="fe378" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="805.7552118446346" CenterY="36.96117249737806" Width="90.0" Height="25.0" ZOrder="32796" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:15541" />
  </DataNode>
  <DataNode TextLabel="CoA(20:0)" GraphId="efdb4" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="715.7552118446348" CenterY="61.96117249737808" Width="90.0" Height="25.0" ZOrder="32797" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:15527" />
  </DataNode>
  <DataNode TextLabel="CoA(22:0)" GraphId="e18f7" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="805.7552118446346" CenterY="61.96117249737808" Width="90.0" Height="25.0" ZOrder="32798" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="24330-89-0" />
  </DataNode>
  <DataNode TextLabel="CoA(24:0)" GraphId="a179b" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="715.7552118446348" CenterY="86.96117249737807" Width="90.0" Height="25.0" ZOrder="32799" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="24305-30-4" />
  </DataNode>
  <DataNode TextLabel="CoA(24:1)" GraphId="c7424" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="805.7552118446346" CenterY="86.96117249737807" Width="90.0" Height="25.0" ZOrder="32800" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="88362-35-0" />
  </DataNode>
  <DataNode TextLabel="CoA(16:0)" GraphId="abbf5" Type="Metabolite">
    <Graphics CenterX="1286.4349529687574" CenterY="82.22446450135992" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32802" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA07050360" />
  </DataNode>
  <DataNode TextLabel="CoA(18:0)" GraphId="b07bd" Type="Metabolite">
    <Graphics CenterX="1286.9743289659436" CenterY="234.33714055769806" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32803" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:15541" />
  </DataNode>
  <DataNode TextLabel="CoA(20:0)" GraphId="f0afd" Type="Metabolite">
    <Graphics CenterX="1242.4432824279213" CenterY="387.85826731826194" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32804" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:15527" />
  </DataNode>
  <DataNode TextLabel="CoA(22:0)" GraphId="c1c64" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​docosanoate"</Comment>
    <Graphics CenterX="1337.3488556082075" CenterY="387.85826731826194" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32805" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="24330-89-0" />
  </DataNode>
  <DataNode TextLabel="CoA(24:0)" GraphId="ef435" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​(tetracosanoate)​"</Comment>
    <Graphics CenterX="1244.8643163014908" CenterY="551.2385490084023" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32806" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="24305-30-4" />
  </DataNode>
  <DataNode TextLabel="CoA(24:1)" GraphId="e3f72" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"</Comment>
    <Graphics CenterX="1338.4276076025826" CenterY="551.2385490084023" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32807" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="88362-35-0" />
  </DataNode>
  <DataNode TextLabel="DH-Ceramide" GraphId="f9b34" Type="Metabolite">
    <Graphics CenterX="1286.4349529687574" CenterY="178.6634598165359" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32808" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020000" />
  </DataNode>
  <DataNode TextLabel="DH-Ceramide" GraphId="f2a27" Type="Metabolite">
    <Graphics CenterX="1286.9743289659436" CenterY="330.77613587287453" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32809" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020000" />
  </DataNode>
  <DataNode TextLabel="DH-Ceramide" GraphId="cc18d" Type="Metabolite">
    <Graphics CenterX="1288.0215013481172" CenterY="484.2972626334377" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32811" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020000" />
  </DataNode>
  <DataNode TextLabel="DH-Ceramide" GraphId="aceae" Type="Metabolite">
    <Graphics CenterX="1292.8371741197716" CenterY="647.6775443235779" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32813" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020000" />
  </DataNode>
  <DataNode TextLabel="CerS1" GraphId="ac8a6" Type="Protein" GroupRef="d4bdd">
    <Graphics CenterX="1231.4917804137635" CenterY="269.5016644247988" Width="52.95614268548025" Height="25.0" ZOrder="32820" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P27545" />
  </DataNode>
  <DataNode TextLabel="CerS4" GraphId="fc613" Type="Protein">
    <Graphics CenterX="1288.5314754569397" CenterY="419.34880964260884" Width="52.95614268548025" Height="25.0" ZOrder="32824" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="67260" />
  </DataNode>
  <DataNode TextLabel="Cers2" GraphId="fed26" Type="Protein">
    <Graphics CenterX="1291.3851990924109" CenterY="581.2343230218369" Width="52.956142685480245" Height="25.0" ZOrder="32827" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="76893" />
  </DataNode>
  <DataNode TextLabel="CoA(26:0)" GraphId="ae76f" Type="Metabolite">
    <Comment>AKA "Coenzyme A, S-​hexacosanoate"</Comment>
    <Graphics CenterX="1248.8261385293467" CenterY="692.083619430937" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32829" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="99313-57-2" />
  </DataNode>
  <DataNode TextLabel="CoA(26:1)" GraphId="b6b95" Type="Metabolite">
    <Graphics CenterX="1343.6402685642295" CenterY="692.1907917310195" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32830" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="DH-Ceramide" GraphId="d3fb3" Type="Metabolite">
    <Graphics CenterX="1300.3834306931892" CenterY="788.5226147461126" Width="94.90557318028613" Height="25.000000000000004" ZOrder="32832" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMSP02020000" />
  </DataNode>
  <DataNode TextLabel="Cers3" GraphId="f166f" Type="Protein">
    <Graphics CenterX="1298.7931485147683" CenterY="724.3215459107397" Width="52.956142685480245" Height="25.0" ZOrder="32837" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q1A3B0" />
  </DataNode>
  <DataNode TextLabel="CoA(26:0)" GraphId="f9a59" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="715.7552118446348" CenterY="111.96117249737856" Width="89.99999999999996" Height="25.000000000000014" ZOrder="32839" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="CAS" ID="99313-57-2" />
  </DataNode>
  <DataNode TextLabel="CoA(26:1)" GraphId="b12b3" Type="Metabolite" GroupRef="af21a">
    <Graphics CenterX="805.7552118446346" CenterY="111.9611724973781" Width="89.99999999999996" Height="25.0" ZOrder="32840" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="ADP" GraphId="aeba0" Type="Metabolite">
    <Graphics CenterX="359.0789473684206" CenterY="581.578947368421" Width="59.73684210526337" Height="25.0" ZOrder="32841" FontSize="12" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
    <Xref Database="ChEBI" ID="CHEBI:456216" />
  </DataNode>
  <DataNode TextLabel="Sgpp2" GraphId="a9f9a" Type="Protein" GroupRef="ba605">
    <Graphics CenterX="118.9473684210526" CenterY="557.6315789473686" Width="90.0" Height="25.0" ZOrder="32843" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q810K3" />
  </DataNode>
  <Interaction GraphId="id11c71881">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="260.52538196607225" Y="357.0" GraphRef="a3300" RelX="0.0" RelY="1.0" />
      <Point X="259.45224553850534" Y="462.78410689170175" GraphRef="ed964" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="a8460" />
    </Graphics>
    <Xref Database="Rhea" ID="22642" />
  </Interaction>
  <Interaction GraphId="id1472a2e3">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="258.68942108158626" Y="667.8243468042979" GraphRef="c54f2" RelX="0.0" RelY="0.0" />
      <Point X="515.512911340217" Y="720.2552742616041" GraphRef="f4ce4" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id1aec68d4">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="166.8955370048315" Y="399.08333333333337" GraphRef="de6f3" RelX="1.0" RelY="0.0" />
      <Point X="260.09612739504547" Y="399.3136427566807" GraphRef="a8460" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id204b067">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="820.2096572806357" Y="403.875" GraphRef="bf530" RelX="1.0" RelY="0.5" />
      <Point X="987.8471396997593" Y="403.875" GraphRef="e9d8d" RelX="-1.0" RelY="0.5" ArrowHead="mim-conversion" />
      <Anchor Position="0.629218832916282" Shape="None" GraphId="abc88" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id20e811f3">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="859.6484758460344" Y="568.5961673699013" GraphRef="feaff" RelX="-1.0" RelY="0.0" />
      <Point X="800.2198541864055" Y="568.4444444444448" GraphRef="b29de" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id29679d60">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="339.78557887183865" Y="477.03410689170175" GraphRef="ed964" RelX="1.0" RelY="0.0" />
      <Point X="417.67353011421966" Y="315.74737697772764" />
      <Point X="760.983613110104" Y="154.46064706375353" GraphRef="afbb2" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id2cf5a716">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="552.4512611034355" Y="308.9552238805972" GraphRef="c268f" RelX="1.0" RelY="-0.5" />
      <Point X="571.7049924467191" Y="308.2089552238807" />
      <Point X="616.7701510080417" Y="307.46268656716416" />
      <Point X="661.8353095693644" Y="247.22310846018314" GraphRef="ca6bf" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id2fa1d96b">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="739.1710465305932" Y="306.05000982049467" GraphRef="fb07d" RelX="1.0" RelY="0.0" />
      <Point X="761.4596572806357" Y="305.4263565891473" GraphRef="b938a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id3752d4e4">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="944.6777512536523" Y="320.2239903975606" GraphRef="cbfa3" RelX="0.0" RelY="1.0" />
      <Point X="811.7218687809363" Y="367.04151169453553" GraphRef="acb81" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id45ffb504">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="465.9159724830165" Y="373.12483631601896" GraphRef="ac40d" RelX="0.0" RelY="1.0" />
      <Point X="663.8020349037268" Y="430.9587093278811" GraphRef="c3008" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id46848a70">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="732.0846572806357" Y="200.31293952180025" GraphRef="c997e" RelX="-0.5" RelY="-1.0" />
      <Point X="646.4391122289321" Y="179.4629629629628" GraphRef="cc25d" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
      <Anchor Position="0.4" Shape="None" GraphId="ab0aa" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id6cf838b">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="260.0253819660725" Y="127.0" GraphRef="b7caa" RelX="0.0" RelY="1.0" />
      <Point X="260.52538196607225" Y="310.5" GraphRef="a3300" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4004838636372226" Shape="None" GraphId="aa5ea" />
    </Graphics>
    <Xref Database="Rhea" ID="14762" />
  </Interaction>
  <Interaction GraphId="id6dd64cb8">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1286.4349529687574" Y="94.72446450135992" GraphRef="abbf5" RelX="0.0" RelY="1.0" />
      <Point X="1286.4349529687574" Y="166.1634598165359" GraphRef="f9b34" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.47556324386737214" Shape="None" GraphId="cb42d" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id7451d8ea">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="790.8346572806357" Y="228.81293952180025" GraphRef="c997e" RelX="0.5" RelY="1.0" />
      <Point X="843.0526860313873" Y="280.97933270823546" GraphRef="c9f6c" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="e5204" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id765f7ea9">
    <BiopaxRef>b39</BiopaxRef>
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="171.9473684210526" Y="545.1315789473686" GraphRef="e9f31" RelX="1.0" RelY="0.0" />
      <Point X="219.19658251621775" Y="545.2583618678739" GraphRef="e0038" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id79689790">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="732.0846572806357" Y="228.81293952180025" GraphRef="c997e" RelX="-0.5" RelY="1.0" />
      <Point X="594.2465714876168" Y="264.9360143725812" GraphRef="e6a32" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.5096512136475798" Shape="None" GraphId="ca6bf" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id7a708c67">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="944.6777512536523" Y="300.2239903975606" GraphRef="cbfa3" RelX="0.0" RelY="-1.0" />
      <Point X="811.7218687809363" Y="249.67949679637434" GraphRef="e5204" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id82b82715">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="299.618912205172" Y="491.28410689170175" GraphRef="ed964" RelX="0.5" RelY="1.0" />
      <Point X="299.4420486327389" Y="598.5478199718711" GraphRef="f368e" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.48366739822863825" Shape="None" GraphId="a78e1" />
    </Graphics>
    <Xref Database="Rhea" ID="15466" />
  </Interaction>
  <Interaction GraphId="id874d313b">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="552.4512611034355" Y="320.8955223880599" GraphRef="c268f" RelX="1.0" RelY="0.5" />
      <Point X="663.8020349037268" Y="380.5336150739865" GraphRef="b20a1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id924ac751">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="761.4596572806357" Y="411.0" GraphRef="bf530" RelX="0.0" RelY="1.0" />
      <Point X="760.0531875197355" Y="498.28938115330516" GraphRef="f88b3" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6891235390038983" Shape="None" GraphId="cc60b" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id9535ea46">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="325.52631578947324" Y="512.6315789473686" GraphRef="a01f7" RelX="-1.0" RelY="0.0" />
      <Point X="299.53336906125185" Y="543.1640679215304" GraphRef="a78e1" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="Rhea" ID="15466" />
  </Interaction>
  <Interaction GraphId="id96290d76">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="760.0531875197412" Y="630.3811533052046" GraphRef="b32ff" RelX="0.0" RelY="1.0" />
      <Point X="760.0531875197355" Y="720.255274261604" GraphRef="ba579" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.403737059960402" Shape="None" GraphId="e70e1" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id981fc8c8">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="398.02538196606986" Y="130.33333333333334" GraphRef="c3e72" RelX="0.0" RelY="1.0" />
      <Point X="260.225623897891" Y="200.48878897743035" GraphRef="aa5ea" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id9884255a">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="702.7096572806357" Y="389.625" GraphRef="bf530" RelX="-1.0" RelY="-0.5" />
      <Point X="605.4406013383634" Y="366.8965376849662" GraphRef="d60ba" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="b20a1" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id9d280dab">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="985.8471396997593" Y="221.68793952180027" GraphRef="ba26f" RelX="-1.0" RelY="0.5" />
      <Point X="820.2096572806357" Y="221.68793952180025" GraphRef="c997e" RelX="1.0" RelY="0.5" ArrowHead="mim-conversion" />
      <Anchor Position="0.14454685887107652" Shape="None" GraphId="f2bba" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ida1231f2e">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1034.813102141074" Y="300.3169014084507" GraphRef="fe827" RelX="0.0" RelY="-1.0" />
      <Point X="961.9047619047618" Y="221.68793952180027" GraphRef="f2bba" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idaad03b91">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="760.7552118446347" Y="132.46117249737858" GraphRef="bfe17" RelX="0.0" RelY="1.0" />
      <Point X="761.4596572806357" Y="200.31293952180025" GraphRef="c997e" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.32422846936995403" Shape="None" GraphId="afbb2" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idae7f7f89">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="559.603820431126" Y="667.9746835443043" GraphRef="bd74a" RelX="1.0" RelY="0.0" />
      <Point X="760.0531875197389" Y="666.6666666666669" GraphRef="e70e1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idaf973609">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="469.603820431126" Y="667.9746835443043" GraphRef="bd74a" RelX="-1.0" RelY="0.0" />
      <Point X="258.68942108158626" Y="667.8243468042979" GraphRef="c54f2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idb39e1f3c">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="180.0205370048315" Y="200.63372093023204" GraphRef="e69f4" RelX="1.0" RelY="0.0" />
      <Point X="260.225623897891" Y="200.48878897743035" GraphRef="aa5ea" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idb9579e0d">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="790.8346572806357" Y="382.5" GraphRef="bf530" RelX="0.5" RelY="-1.0" />
      <Point X="843.0526860313873" Y="343.8537792363389" GraphRef="be1a4" RelX="0.0" RelY="1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="acb81" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idbb8ae26">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="219.10871529940553" Y="598.5478199718711" GraphRef="f368e" RelX="-0.5" RelY="-1.0" />
      <Point X="219.28557887183868" Y="491.28410689170175" GraphRef="ed964" RelX="-0.5" RelY="1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4968078819364429" Shape="None" GraphId="e0038" />
    </Graphics>
    <Xref Database="Rhea" ID="27515" />
  </Interaction>
  <Interaction GraphId="idbdf2f556">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="719.8865208530689" Y="523.2893811533052" GraphRef="f88b3" RelX="-0.5" RelY="1.0" />
      <Point X="719.8865208530746" Y="598.5478199718711" GraphRef="b32ff" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.2640037967228627" Shape="None" GraphId="a5e51" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc2904d49">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="259.2753819660722" Y="630.3811533052046" GraphRef="f368e" RelX="0.0" RelY="1.0" />
      <Point X="257.8689122051721" Y="720.255274261604" GraphRef="d0961" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.41661818886949686" Shape="None" GraphId="c54f2" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc444fee0">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="820.2096572806357" Y="207.43793952180025" GraphRef="c997e" RelX="1.0" RelY="-0.5" />
      <Point X="985.8471396997593" Y="207.43793952180027" GraphRef="ba26f" RelX="-1.0" RelY="-0.5" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="f7a25" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc931ada7">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="987.8471396997593" Y="389.625" GraphRef="e9d8d" RelX="-1.0" RelY="-0.5" />
      <Point X="820.2096572806357" Y="389.625" GraphRef="bf530" RelX="1.0" RelY="-0.5" ArrowHead="mim-conversion" />
      <Anchor Position="0.16611523448041574" Shape="None" GraphId="ae05e" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idca8136b2">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="761.4596572806357" Y="228.81293952180025" GraphRef="c997e" RelX="0.0" RelY="1.0" />
      <Point X="761.4596572806357" Y="382.5" GraphRef="bf530" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.49850271603193647" Shape="None" GraphId="b938a" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idd65a3387">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="465.9159724830165" Y="353.12483631601896" GraphRef="ac40d" RelX="0.0" RelY="-1.0" />
      <Point X="573.6715036933717" Y="214.15607985480943" />
      <Point X="697.8264392599543" Y="191.97294889826526" GraphRef="ab0aa" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="iddbfe9fa1">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="1129.4371712493132" Y="339.43022187778024" GraphRef="a8e79" RelX="0.0" RelY="1.0" />
      <Point X="1027.563744785367" Y="445.8509142053446" />
      <Point X="925.6903183214204" Y="403.875" GraphRef="abc88" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="iddcdb3ebd">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="1034.813102141074" Y="321.8169014084507" GraphRef="fe827" RelX="0.0" RelY="1.0" />
      <Point X="960.0" Y="389.625" GraphRef="ae05e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ide0bbc0c3">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="800.2198541864078" Y="598.5478199718711" GraphRef="b32ff" RelX="0.5" RelY="-1.0" />
      <Point X="800.2198541864021" Y="523.2893811533052" GraphRef="f88b3" RelX="0.5" RelY="1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="b29de" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idf29bfd2c">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="702.7096572806357" Y="403.875" GraphRef="bf530" RelX="-1.0" RelY="0.5" />
      <Point X="605.4406013383634" Y="471.5842733197027" GraphRef="dea07" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4" Shape="None" GraphId="c3008" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idf3d315c9">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
      <Point X="1129.4371712493132" Y="280.9302218777807" GraphRef="a8e79" RelX="0.0" RelY="-1.0" />
      <Point X="1007.9509107487992" Y="168.77637130801688" />
      <Point X="886.4646502482851" Y="207.43793952180025" GraphRef="f7a25" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idf779ba24">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="760.0531875197389" Y="666.6666666666669" GraphRef="e70e1" RelX="0.0" RelY="0.0" />
      <Point X="515.512911340217" Y="720.2552742616041" GraphRef="f4ce4" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idf9bd034">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="730.1910215563021" Y="470.25879043600634" GraphRef="b614f" RelX="1.0" RelY="0.0" />
      <Point X="760.4904258615022" Y="471.1531672578258" GraphRef="cc60b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idfd30c455">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="463.0102901920261" Y="542.1401908788723" GraphRef="ce853" RelX="-1.0" RelY="0.0" />
      <Point X="299.53336906125185" Y="543.1640679215304" GraphRef="a78e1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idfee96b1a">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="569.0102901920261" Y="542.1401908788723" GraphRef="ce853" RelX="1.0" RelY="0.0" />
      <Point X="719.8865208530704" Y="543.1578947368419" GraphRef="a5e51" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="efb40">
    <Graphics ZOrder="32814" LineThickness="1.0">
      <Point X="1286.9743289659436" Y="246.83714055769806" GraphRef="b07bd" RelX="0.0" RelY="1.0" />
      <Point X="1286.9743289659436" Y="318.27613587287453" GraphRef="f2a27" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.4781258250072417" Shape="None" GraphId="a8f13" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="cba2e">
    <Graphics ZOrder="32815" LineThickness="1.0">
      <Point X="1242.4432824279215" Y="400.35826731826194" GraphRef="f0afd" RelX="0.0" RelY="1.0" />
      <Point X="1264.2951080530459" Y="471.7972626334377" GraphRef="cc18d" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6463920682111056" Shape="None" GraphId="e8fc0" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b5996">
    <Graphics ZOrder="32816" LineThickness="1.0">
      <Point X="1337.3488556082075" Y="400.35826731826194" GraphRef="c1c64" RelX="0.0" RelY="1.0" />
      <Point X="1311.747894643189" Y="471.7972626334377" GraphRef="cc18d" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6735613865368164" Shape="None" GraphId="d16aa" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="af2e4">
    <Graphics ZOrder="32817" LineThickness="1.0">
      <Point X="1244.8643163014908" Y="563.7385490084023" GraphRef="ef435" RelX="0.0" RelY="1.0" />
      <Point X="1269.1107808247" Y="635.1775443235779" GraphRef="aceae" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6754355571891035" Shape="None" GraphId="c5b91" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e27f1">
    <Graphics ZOrder="32818" LineThickness="1.0">
      <Point X="1338.4276076025826" Y="563.7385490084023" GraphRef="e3f72" RelX="0.0" RelY="1.0" />
      <Point X="1316.5635674148432" Y="635.1775443235779" GraphRef="aceae" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.659531446958284" Shape="None" GraphId="dc646" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="b36ce">
    <Graphics ZOrder="32819" LineThickness="1.0">
      <Point X="1259.651795023691" Y="128.40094220193123" GraphRef="c7a3b" RelX="1.0" RelY="0.0" />
      <Point X="1286.4349529687574" Y="128.698224852071" GraphRef="cb42d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="aa321">
    <Graphics ZOrder="32821" LineThickness="1.0">
      <Point X="1265.9698517565039" Y="282.00166442479883" GraphRef="da538" RelX="1.0" RelY="0.0" />
      <Point X="1286.9743289659436" Y="280.9939691304553" GraphRef="a8f13" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="e7095">
    <Graphics ZOrder="32823" LineThickness="1.0">
      <Point X="1275.2924397855695" Y="431.84880964260884" GraphRef="fc613" RelX="-0.5" RelY="1.0" />
      <Point X="1256.5681291879341" Y="446.53586725096187" GraphRef="e8fc0" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="d54e4">
    <Graphics ZOrder="32825" LineThickness="1.0">
      <Point X="1301.7705111283099" Y="431.84880964260884" GraphRef="fc613" RelX="0.5" RelY="1.0" />
      <Point X="1320.1050368439348" Y="448.47681605554885" GraphRef="d16aa" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="bde74">
    <Graphics ZOrder="32826" LineThickness="1.0">
      <Point X="1278.146163421041" Y="593.7343230218369" GraphRef="fed26" RelX="-0.5" RelY="1.0" />
      <Point X="1261.2412405765904" Y="611.9909866141377" GraphRef="c5b91" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="c9b6b">
    <Graphics ZOrder="32828" LineThickness="1.0">
      <Point X="1304.6242347637808" Y="593.7343230218369" GraphRef="fed26" RelX="0.5" RelY="1.0" />
      <Point X="1324.0075855412088" Y="610.8548129578661" GraphRef="dc646" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ca493">
    <Graphics ZOrder="32833" LineThickness="1.0">
      <Point X="1248.8261385293467" Y="704.583619430937" GraphRef="ae76f" RelX="0.0" RelY="1.0" />
      <Point X="1276.6570373981178" Y="776.0226147461126" GraphRef="d3fb3" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.6930899883380343" Shape="None" GraphId="b0e5b" />
      <Anchor Position="0.4" Shape="None" GraphId="ec86d" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="aa3b3">
    <Graphics ZOrder="32834" LineThickness="1.0">
      <Point X="1343.6402685642297" Y="704.6907917310195" GraphRef="b6b95" RelX="0.0" RelY="1.0" />
      <Point X="1324.109823988261" Y="776.0226147461126" GraphRef="d3fb3" RelX="0.5" RelY="-1.0" ArrowHead="mim-conversion" />
      <Anchor Position="0.7118275756247109" Shape="None" GraphId="aa5cc" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="db3cb">
    <Graphics ZOrder="32836" LineThickness="1.0">
      <Point X="1285.5541128433983" Y="736.8215459107397" GraphRef="f166f" RelX="-0.5" RelY="1.0" />
      <Point X="1268.1154559017402" Y="754.097271860813" GraphRef="b0e5b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="fdd42">
    <Graphics ZOrder="32838" LineThickness="1.0">
      <Point X="1312.0321841861382" Y="736.8215459107397" GraphRef="f166f" RelX="0.5" RelY="1.0" />
      <Point X="1329.737959550845" Y="755.4667503727442" GraphRef="aa5cc" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="dd0d4">
    <Graphics ZOrder="32842" LineThickness="1.0">
      <Point X="299.53336906125185" Y="543.1640679215304" GraphRef="a78e1" RelX="0.0" RelY="0.0" />
      <Point X="329.2105263157889" Y="581.578947368421" GraphRef="aeba0" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="Rhea" ID="15466" />
  </Interaction>
  <Interaction GraphId="fa914">
    <Graphics ZOrder="32844" LineThickness="1.0">
      <Point X="150.5263157894737" Y="597.8947368421047" GraphRef="f7997" RelX="1.0" RelY="0.0" />
      <Point X="219.19658251621775" Y="545.2583618678739" GraphRef="e0038" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" />
    </Graphics>
    <Xref Database="Rhea" ID="27515" />
  </Interaction>
  <Label TextLabel="N-acyl chains:" GraphId="b8214">
    <Graphics CenterX="1285.553691275168" CenterY="38.92617449664429" Width="183.25503355704723" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="22" Valign="Middle" Color="404040" />
  </Label>
  <Group GroupId="c13d0" GraphId="a6c1c" Style="Group" />
  <Group GroupId="d945f" GraphId="a8e79" Style="Group" />
  <Group GroupId="af21a" GraphId="bfe17" Style="Group" />
  <Group GroupId="fa178" GraphId="c7a3b" Style="Group" />
  <Group GroupId="e505a" GraphId="ce853" Style="Group" />
  <Group GroupId="d4bdd" GraphId="da538" Style="Group" />
  <Group GroupId="f0511" GraphId="e69f4" Style="Group" />
  <Group GroupId="ba605" GraphId="e9f31" Style="Group" />
  <Group GroupId="c0c64" GraphId="fb07d" Style="Group" />
  <Group GroupId="e29dc" GraphId="feaff" Style="Group" />
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingolipid biosynthetic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000162</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11756451</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Characterization of murine sphingosine-1-phosphate phosphohydrolase.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Le Stunff H</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peterson C</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thornton R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milstien S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mandala SM</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spiegel S</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingolipid metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000197</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingomyelin metabolic pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000745</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b6c">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12011104</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merrill AH Jr</bp:AUTHORS>
    </bp:PublicationXref>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fc1">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20923771</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A mouse macrophage lipidome.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dennis EA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Deems RA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harkewicz R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quehenberger O</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown HA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milne SB</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Myers DS</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glass CK</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hardiman G</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reichart D</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merrill AH Jr</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sullards MC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murphy RC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Raetz CR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Garrett TA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guan Z</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ryan AC</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Russell DW</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McDonald JG</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thompson BM</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shaw WA</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sud M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhao Y</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gupta S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maurya MR</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fahy E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Subramaniam S</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>

