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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Mapk cascade" Data-Source="WikiPathways" Version="WP251_r116722" Author="[Nsalomonis, MaintBot, I.Reyes, Michiel, Ddigles, Mkutmon, Egonw, Eweitz]" Last-Modified="20210511100208" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.</Comment>
  <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP422_r95146 WP422 (r95146)] with a 96.0% conversion rate.</Comment>
  <BiopaxRef>fa2</BiopaxRef>
  <BiopaxRef>d05</BiopaxRef>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1432</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK14 | mitogen-activated protein kinase 14" />
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    <Xref Database="Ensembl" ID="ENSMUSG00000053436" />
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  <DataNode TextLabel="Jun" GraphId="a80" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="JUN | v-jun sarcoma virus 17 oncogene homolog (..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000052684" />
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  <DataNode TextLabel="Nras" GraphId="aa7" Type="GeneProduct" GroupRef="db21b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4893</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NRAS | neuroblastoma RAS viral (v-ras) oncogene..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000027852" />
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  <DataNode TextLabel="Raf1" GraphId="b3e" Type="GeneProduct" GroupRef="b3965">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5894</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1 | v-raf-1 murine leukemia viral oncogene h..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000000441" />
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  <DataNode TextLabel="Map2k7" GraphId="b61" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5609</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K7 | mitogen-activated protein kinase kinas..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000109061" />
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  <DataNode TextLabel="Map3k3" GraphId="b86" Type="GeneProduct" GroupRef="ac569">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4215</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K3 | mitogen-activated protein kinase kinas..." />
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    <Xref Database="Ensembl" ID="ENSMUSG00000020700" />
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  <DataNode TextLabel="GTP" GraphId="b92" Type="Metabolite">
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  <DataNode TextLabel="Map3k1" GraphId="c37" Type="GeneProduct" GroupRef="ac569">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K1 | mitogen-activated protein kinase kinas..." />
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  <DataNode TextLabel="Mapk3" GraphId="c44" Type="GeneProduct" GroupRef="ec9e0">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5595</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3 | mitogen-activated protein kinase 3" />
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  <DataNode TextLabel="Elk1" GraphId="c75" Type="GeneProduct" GroupRef="b1a21">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ELK1 | ELK1 member of ETS oncogene family" />
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  <DataNode TextLabel="Map2" GraphId="c80" Type="GeneProduct" GroupRef="b1a21">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4133</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2" />
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  <DataNode TextLabel="Map2k4" GraphId="c82" Type="GeneProduct" GroupRef="e1fd1">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416</Comment>
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  <DataNode TextLabel="Hras" GraphId="c98" Type="GeneProduct" GroupRef="db21b">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3265</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HRAS | v-Ha-ras Harvey rat sarcoma viral oncoge..." />
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  <DataNode TextLabel="Map3k12" GraphId="c9d" Type="GeneProduct" GroupRef="ac569">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7786</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K12 | mitogen-activated protein kinase kina..." />
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  <DataNode TextLabel="Mapk10" GraphId="d09" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10" />
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  <DataNode TextLabel="Map2k2" GraphId="d26" Type="GeneProduct" GroupRef="c6e1d">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5605</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2 | mitogen-activated protein kinase kinas..." />
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  <DataNode TextLabel="Mbp" GraphId="d43" Type="GeneProduct" GroupRef="b1a21">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4155</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="mbp" />
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  <DataNode TextLabel="Mapk12" GraphId="d6e" Type="GeneProduct" GroupRef="cbcc8">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6300</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK12 | mitogen-activated protein kinase 12" />
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  <DataNode TextLabel="Map2k6" GraphId="e5d" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5608</Comment>
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  <DataNode TextLabel="Sipa1" GraphId="e79" Type="GeneProduct">
    <Comment Source="GenMAPP remarks">not confirmed SwissProt ID - mu: SPA1 MOUSE</Comment>
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6494</Comment>
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  <DataNode TextLabel="Mapk1" GraphId="e83" Type="GeneProduct" GroupRef="ec9e0">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5594</Comment>
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  <DataNode TextLabel="Rasa3" GraphId="ead" Type="GeneProduct">
    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22821</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6237</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:369</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARAF | v-raf murine sarcoma 3611 viral oncogene..." />
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3845</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10746</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:673</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5604</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5606</Comment>
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    <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331</Comment>
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