<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Dopaminergic neurogenesis" Data-Source="WikiPathways" Version="WP1498_r135872" Author="[Zans, Khanspers, MaintBot, Samuel Sklar, Egonw, Evelo, Mkutmon, Eweitz]" Last-Modified="20241120122412" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Process describing various stages of dopaminergic neurogenesis. See also https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=141</Comment>
  <Graphics BoardWidth="702.0" BoardHeight="488.0" />
  <DataNode TextLabel="Retinoic acid" GraphId="a4a4a" Type="Metabolite">
    <Graphics CenterX="124.0" CenterY="394.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
    <Xref Database="HMDB" ID="HMDB0001852" />
  </DataNode>
  <DataNode TextLabel="Neurod1" GraphId="a5a44" Type="GeneProduct">
    <Graphics CenterX="463.0" CenterY="387.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000034701" />
  </DataNode>
  <DataNode TextLabel="Otx2" GraphId="a8714" Type="GeneProduct">
    <Graphics CenterX="292.0" CenterY="238.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18424" />
  </DataNode>
  <DataNode TextLabel="Cdkn1c" GraphId="aaf65" Type="GeneProduct">
    <Graphics CenterX="611.0" CenterY="268.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12577" />
  </DataNode>
  <DataNode TextLabel="En2" GraphId="ad3fd" Type="GeneProduct">
    <Graphics CenterX="463.0" CenterY="144.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13799" />
  </DataNode>
  <DataNode TextLabel="Lmx1b" GraphId="b585a" Type="GeneProduct">
    <Graphics CenterX="462.0" CenterY="178.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16917" />
  </DataNode>
  <DataNode TextLabel="Wnt1" GraphId="b87d4" Type="GeneProduct">
    <Graphics CenterX="292.0" CenterY="270.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22408" />
  </DataNode>
  <DataNode TextLabel="Gli2" GraphId="b8bba" Type="GeneProduct">
    <Graphics CenterX="291.0" CenterY="173.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14633" />
  </DataNode>
  <DataNode TextLabel="Neurog2" GraphId="b9411" Type="GeneProduct">
    <Graphics CenterX="462.0" CenterY="315.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11924" />
  </DataNode>
  <DataNode TextLabel="Msx1" GraphId="ba43b" Type="GeneProduct">
    <Graphics CenterX="293.0" CenterY="301.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="17701" />
  </DataNode>
  <DataNode TextLabel="Aadc" GraphId="bc51a" Type="GeneProduct">
    <Graphics CenterX="612.0" CenterY="148.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13195" />
  </DataNode>
  <DataNode TextLabel="Stat3" GraphId="bde08" Type="GeneProduct">
    <Graphics CenterX="290.25" CenterY="371.75" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20848" />
  </DataNode>
  <DataNode TextLabel="Ahd2" GraphId="beafc" Type="GeneProduct">
    <Graphics CenterX="290.25" CenterY="112.25" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="11668" />
  </DataNode>
  <DataNode TextLabel="Dat1" GraphId="c0565" Type="GeneProduct">
    <Graphics CenterX="613.0" CenterY="182.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13162" />
  </DataNode>
  <DataNode TextLabel="En1" GraphId="c08d7" Type="GeneProduct">
    <Graphics CenterX="124.0" CenterY="235.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13798" />
  </DataNode>
  <DataNode TextLabel="Nkx2-2" GraphId="c0ff9" Type="GeneProduct">
    <Graphics CenterX="290.0" CenterY="448.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18088" />
  </DataNode>
  <DataNode TextLabel="Nurr1" GraphId="c112b" Type="GeneProduct">
    <Graphics CenterX="463.0" CenterY="212.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18227" />
  </DataNode>
  <DataNode TextLabel="Th" GraphId="c1c13" Type="GeneProduct">
    <Graphics CenterX="612.0" CenterY="115.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="21823" />
  </DataNode>
  <DataNode TextLabel="Mash1" GraphId="ca368" Type="GeneProduct">
    <Graphics CenterX="463.0" CenterY="350.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="17172" />
  </DataNode>
  <DataNode TextLabel="Ret" GraphId="ce9dc" Type="GeneProduct">
    <Graphics CenterX="611.0" CenterY="297.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="19713" />
  </DataNode>
  <DataNode TextLabel="Pitx3" GraphId="cf5d0" Type="GeneProduct">
    <Graphics CenterX="463.75" CenterY="281.75" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18742" />
  </DataNode>
  <DataNode TextLabel="Vmat2" GraphId="d3118" Type="GeneProduct">
    <Graphics CenterX="613.0" CenterY="212.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="214084" />
  </DataNode>
  <DataNode TextLabel="En2" GraphId="d6017" Type="GeneProduct">
    <Graphics CenterX="123.0" CenterY="263.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13799" />
  </DataNode>
  <DataNode TextLabel="Lmx1b" GraphId="d7ce0" Type="GeneProduct">
    <Graphics CenterX="124.0" CenterY="204.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16917" />
  </DataNode>
  <DataNode TextLabel="Wnt1" GraphId="d8a94" Type="GeneProduct">
    <Graphics CenterX="125.0" CenterY="359.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="22408" />
  </DataNode>
  <DataNode TextLabel="Fgf8" GraphId="dc48f" Type="GeneProduct">
    <Graphics CenterX="124.0" CenterY="326.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14179" />
  </DataNode>
  <DataNode TextLabel="Otx2" GraphId="e4d7b" Type="GeneProduct">
    <Graphics CenterX="125.0" CenterY="142.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18424" />
  </DataNode>
  <DataNode TextLabel="Nkx6-1" GraphId="e6fab" Type="GeneProduct">
    <Graphics CenterX="464.0" CenterY="419.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18096" />
  </DataNode>
  <DataNode TextLabel="Pitx3" GraphId="e8b1e" Type="GeneProduct">
    <Graphics CenterX="611.0" CenterY="240.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="18742" />
  </DataNode>
  <DataNode TextLabel="Gbx2" GraphId="e98b1" Type="GeneProduct">
    <Graphics CenterX="125.0" CenterY="114.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14472" />
  </DataNode>
  <DataNode TextLabel="Foxa2" GraphId="eb84c" Type="GeneProduct">
    <Graphics CenterX="293.0" CenterY="336.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="15376" />
  </DataNode>
  <DataNode TextLabel="En1" GraphId="ec67d" Type="GeneProduct">
    <Graphics CenterX="461.0" CenterY="114.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13798" />
  </DataNode>
  <DataNode TextLabel="Lmx1a" GraphId="edabe" Type="GeneProduct">
    <Graphics CenterX="291.0" CenterY="205.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="110648" />
  </DataNode>
  <DataNode TextLabel="Gli1" GraphId="f0371" Type="GeneProduct">
    <Graphics CenterX="291.0" CenterY="143.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14632" />
  </DataNode>
  <DataNode TextLabel="Shh" GraphId="f15db" Type="GeneProduct">
    <Graphics CenterX="124.0" CenterY="294.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20423" />
  </DataNode>
  <DataNode TextLabel="Sox2" GraphId="f271e" Type="GeneProduct">
    <Graphics CenterX="291.0" CenterY="404.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20674" />
  </DataNode>
  <DataNode TextLabel="Tgfb1" GraphId="f8117" Type="GeneProduct">
    <Graphics CenterX="124.0" CenterY="172.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="21803" />
  </DataNode>
  <DataNode TextLabel="Foxa2" GraphId="facee" Type="GeneProduct">
    <Graphics CenterX="463.0" CenterY="248.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="15376" />
  </DataNode>
  <Interaction GraphId="id14773e62">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="503.0" Y="212.0" GraphRef="c112b" RelX="1.0" RelY="0.0" />
      <Point X="571.0" Y="268.0" GraphRef="aaf65" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id15c6390a">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="331.0" Y="143.0" GraphRef="f0371" RelX="1.0" RelY="0.0" />
      <Point X="423.0" Y="248.0" GraphRef="facee" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id16daf214">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="502.0" Y="178.0" GraphRef="b585a" RelX="1.0" RelY="0.0" />
      <Point X="501.0" Y="114.0" GraphRef="ec67d" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id1f721b0d">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="85.0" Y="114.0" GraphRef="e98b1" RelX="-1.0" RelY="0.0" />
      <Point X="38.0" Y="204.0" />
      <Point X="84.0" Y="294.0" GraphRef="f15db" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id1ff21c4a">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="ff3333">
      <Point X="330.25" Y="371.75" GraphRef="bde08" RelX="1.0" RelY="0.0" />
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id2459ed9c">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="ff0033">
      <Point X="164.0" Y="326.0" GraphRef="dc48f" RelX="1.0" RelY="0.0" />
      <Point X="250.25" Y="371.75" GraphRef="bde08" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id35dee3bf">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="252.0" Y="270.0" GraphRef="b87d4" RelX="-1.0" RelY="0.0" />
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" ArrowHead="TBar" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id3fe9143">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="253.0" Y="336.0" GraphRef="eb84c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id430ec52a">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" />
      <Point X="423.0" Y="387.0" GraphRef="a5a44" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id45dc23f8">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="503.75" Y="281.75" GraphRef="cf5d0" RelX="1.0" RelY="0.0" />
      <Point X="572.0" Y="115.0" GraphRef="c1c13" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id4cc33ac8">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="502.0" Y="178.0" GraphRef="b585a" RelX="1.0" RelY="0.0" />
      <Point X="571.0" Y="240.0" GraphRef="e8b1e" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id4e145f21">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="332.0" Y="238.0" GraphRef="a8714" RelX="1.0" RelY="0.0" />
      <Point X="423.0" Y="350.0" GraphRef="ca368" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id4fbfa463">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="85.0" Y="114.0" GraphRef="e98b1" RelX="-1.0" RelY="0.0" />
      <Point X="7.0" Y="220.0" />
      <Point X="84.0" Y="326.0" GraphRef="dc48f" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id53dd01c6">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="235.0" GraphRef="c08d7" RelX="1.0" RelY="0.0" />
      <Point X="252.0" Y="270.0" GraphRef="b87d4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id5941562f">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="165.0" Y="142.0" GraphRef="e4d7b" RelX="1.0" RelY="0.0" />
      <Point X="250.0" Y="448.0" GraphRef="c0ff9" RelX="-1.0" RelY="0.0" ArrowHead="TBar" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id59c81f67">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="251.0" Y="143.0" GraphRef="f0371" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id5f9d5661">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="331.0" Y="205.0" GraphRef="edabe" RelX="1.0" RelY="0.0" />
      <Point X="422.0" Y="315.0" GraphRef="b9411" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id675a5e2a">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="251.0" Y="173.0" GraphRef="b8bba" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id6d0b98ae">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="250.0" Y="448.0" GraphRef="c0ff9" RelX="-1.0" RelY="0.0" ArrowHead="TBar" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id7dad2372">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="502.0" Y="315.0" GraphRef="b9411" RelX="1.0" RelY="0.0" />
      <Point X="502.0" Y="178.0" GraphRef="b585a" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id7e7b7430">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" />
      <Point X="357.0" Y="392.0" />
      <Point X="330.0" Y="448.0" GraphRef="c0ff9" RelX="1.0" RelY="0.0" ArrowHead="TBar" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id7f139528">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="85.0" Y="142.0" GraphRef="e4d7b" RelX="-1.0" RelY="0.0" />
      <Point X="19.0" Y="218.0" />
      <Point X="84.0" Y="294.0" GraphRef="f15db" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id813a7903">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" />
      <Point X="423.0" Y="350.0" GraphRef="ca368" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id82473a66">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="84.0" Y="172.0" GraphRef="f8117" RelX="-1.0" RelY="0.0" />
      <Point X="61.0" Y="233.0" />
      <Point X="84.0" Y="294.0" GraphRef="f15db" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id8d176265">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="253.0" Y="301.0" GraphRef="ba43b" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="id97a7e780">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="251.0" Y="205.0" GraphRef="edabe" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idaf611e7e">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="85.0" Y="142.0" GraphRef="e4d7b" RelX="-1.0" RelY="0.0" />
      <Point X="14.0" Y="234.0" />
      <Point X="84.0" Y="326.0" GraphRef="dc48f" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idb01b0981">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="84.0" Y="294.0" GraphRef="f15db" RelX="-1.0" RelY="0.0" />
      <Point X="38.0" Y="204.0" />
      <Point X="85.0" Y="114.0" GraphRef="e98b1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idb4337c3e">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" />
      <Point X="331.0" Y="205.0" GraphRef="edabe" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idb7f338c">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="165.0" Y="142.0" GraphRef="e4d7b" RelX="1.0" RelY="0.0" />
      <Point X="252.0" Y="270.0" GraphRef="b87d4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idbb1e7826">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="85.0" Y="359.0" GraphRef="d8a94" RelX="-1.0" RelY="0.0" />
      <Point X="84.0" Y="326.0" GraphRef="dc48f" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc10db546">
    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0" Color="ff0000">
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" />
      <Point X="250.25" Y="371.75" GraphRef="bde08" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc11e5c89">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="301.0" GraphRef="ba43b" RelX="1.0" RelY="0.0" />
      <Point X="424.0" Y="419.0" GraphRef="e6fab" RelX="-1.0" RelY="0.0" ArrowHead="TBar" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc307a224">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="252.0" Y="270.0" GraphRef="b87d4" RelX="-1.0" RelY="0.0" />
      <Point X="164.0" Y="204.0" GraphRef="d7ce0" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc4103706">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="301.0" GraphRef="ba43b" RelX="1.0" RelY="0.0" />
      <Point X="422.0" Y="315.0" GraphRef="b9411" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc78ba470">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="332.0" Y="270.0" GraphRef="b87d4" RelX="1.0" RelY="0.0" />
      <Point X="421.0" Y="114.0" GraphRef="ec67d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc888bc0f">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="503.0" Y="144.0" GraphRef="ad3fd" RelX="1.0" RelY="0.0" />
      <Point X="572.0" Y="115.0" GraphRef="c1c13" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idc9fd0146">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" />
      <Point X="421.0" Y="114.0" GraphRef="ec67d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idcb4a8be4">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="204.0" GraphRef="d7ce0" RelX="1.0" RelY="0.0" />
      <Point X="252.0" Y="270.0" GraphRef="b87d4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idcc976520">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="331.0" Y="205.0" GraphRef="edabe" RelX="1.0" RelY="0.0" />
      <Point X="333.0" Y="301.0" GraphRef="ba43b" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idcd8796c3">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="164.0" Y="326.0" GraphRef="dc48f" RelX="1.0" RelY="0.0" />
      <Point X="252.0" Y="270.0" GraphRef="b87d4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idcf9a44de">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="332.0" Y="270.0" GraphRef="b87d4" RelX="1.0" RelY="0.0" />
      <Point X="423.75" Y="281.75" GraphRef="cf5d0" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idd4b0d225">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="571.0" Y="268.0" GraphRef="aaf65" RelX="-1.0" RelY="0.0" />
      <Point X="503.0" Y="350.0" GraphRef="ca368" RelX="1.0" RelY="0.0" ArrowHead="TBar" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="ide9580c0a">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="501.0" Y="114.0" GraphRef="ec67d" RelX="1.0" RelY="0.0" />
      <Point X="572.0" Y="115.0" GraphRef="c1c13" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idece3726">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="330.25" Y="371.75" GraphRef="bde08" RelX="1.0" RelY="0.0" />
      <Point X="333.0" Y="301.0" GraphRef="ba43b" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idee2fbb43">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="253.0" Y="336.0" GraphRef="eb84c" RelX="-1.0" RelY="0.0" />
      <Point X="164.0" Y="294.0" GraphRef="f15db" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idfaa4ae60">
    <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
      <Point X="330.25" Y="371.75" GraphRef="bde08" RelX="1.0" RelY="0.0" />
      <Point X="331.0" Y="404.0" GraphRef="f271e" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idfbf6855e">
    <Graphics ZOrder="12288" LineThickness="1.0">
      <Point X="333.0" Y="336.0" GraphRef="eb84c" RelX="1.0" RelY="0.0" />
      <Point X="423.0" Y="212.0" GraphRef="c112b" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
    </Graphics>
    <Xref Database="" ID="" />
  </Interaction>
  <Label TextLabel="Regionalization" GraphId="b0402">
    <Graphics CenterX="128.0" CenterY="66.0" Width="160.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="20" Valign="Middle" />
  </Label>
  <Label TextLabel="Differentiation" GraphId="c452f">
    <Graphics CenterX="460.5" CenterY="66.0" Width="149.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="20" Valign="Middle" />
  </Label>
  <Label TextLabel="Maturation" GraphId="eac71">
    <Graphics CenterX="614.0" CenterY="66.0" Width="116.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="20" Valign="Middle" />
  </Label>
  <Label TextLabel="Specification" GraphId="ee2ff">
    <Graphics CenterX="291.5" CenterY="66.0" Width="127.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="20" Valign="Middle" />
  </Label>
  <InfoBox CenterX="0.0" CenterY="0.0" />
  <Biopax>
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulatory pathway</bp:TERM>
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000004</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
  </Biopax>
</Pathway>

