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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="EPO receptor signaling" Data-Source="WikiPathways" Version="WP1249_r136945" Author="[MaintBot, Thomas, Christine Chichester, Eweitz, Khanspers]" Last-Modified="20250226194534" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: [Wikipedia](https://en.wikipedia.org/wiki/Erythropoietin_receptor)

This pathway is based on ScienceSlides.</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP581&amp;amp;oldid=22574 WP581(r22574)] with a 100% conversion rate.</Comment>
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