<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Cholesterol metabolism with Bloch and Kandutsch-Russell pathways" Data-Source="WikiPathways" Version="WP4346_r137729" Author="[Eoinfahy, Ryanmiller, DeSl, Egonw, Conroy lipids, Eweitz]" Last-Modified="20250307121010" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway is inspired by the Lipidmaps&gt;Sterol lipids expended pathway display [(1)](https://lipidmaps.org/pathway/pathways_maps) and extended with Scheme 1 from Acimovic et al (2013 [pubmed:23558541](https://www.ncbi.nlm.nih.gov/pubmed/23558541)).
Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol (Bae et al, 1997 [pubmed:9291139](https://www.ncbi.nlm.nih.gov/pubmed/9291139)).

Dashed lines indicate that multiple steps are involved to create the final product. Several regulatory effects concerning the metabolites of cholesterol have been indicated as well.
The content from the Bloch and Kandutsch-Russel pathways have been checked against literature, and differences compared to the original LipidMaps pathway have been coloured turquoise.
</Comment>
  <BiopaxRef>c4e</BiopaxRef>
  <BiopaxRef>ee1</BiopaxRef>
  <BiopaxRef>a86</BiopaxRef>
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  <DataNode TextLabel="9Z-palmitoleic acid" GraphId="a0cc9" Type="Metabolite" GroupRef="f4bff">
    <Comment>Assuming this is omega 7-type</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA01030056" />
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  <DataNode TextLabel="Srebf1" GraphId="aa220" Type="GeneProduct">
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    <Xref Database="Ensembl" ID="ENSMUSG00000020538" />
  </DataNode>
  <DataNode TextLabel="7alpha-hydroxycholesterol" GraphId="ab39a" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010013" />
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  <DataNode TextLabel="Acat1" GraphId="ad288" Type="GeneProduct" GroupRef="afa33">
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    <Xref Database="Uniprot-TrEMBL" ID="Q8QZT1" />
  </DataNode>
  <DataNode TextLabel="Abca1" GraphId="b3dae" Type="GeneProduct" GroupRef="f46e6">
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    <Xref Database="Ensembl" ID="ENSMUSG00000015243" />
  </DataNode>
  <DataNode TextLabel="Bloch Pathway" GraphId="b8d73" Type="Pathway">
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    <Xref Database="" ID="" />
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  <DataNode TextLabel="3beta-hydroxylanost-&#xA;8-en-32-al" GraphId="ba907" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010223" />
  </DataNode>
  <DataNode TextLabel="Zymosterone" GraphId="bc229" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010168" />
  </DataNode>
  <DataNode TextLabel="Acetyl-CoA" GraphId="bca2c" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA07050281" />
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  <DataNode TextLabel="4α-formyl-4β-methyl-&#xA;5α-cholesta-8,24-dien-3β-ol" GraphId="bd3af" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010229" />
  </DataNode>
  <DataNode TextLabel="Ch25h" GraphId="bd6fe" Type="GeneProduct">
    <Comment></Comment>
    <Graphics CenterX="785.8337760283616" CenterY="1527.262551372862" Width="64.03938115330558" Height="24.999999999999968" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="12642" />
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  <DataNode TextLabel="Zymostenone" GraphId="c2f93" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010239" />
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  <DataNode TextLabel="Hmgcr" GraphId="c3a79" Type="GeneProduct">
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    <Xref Database="Entrez Gene" ID="15357" />
  </DataNode>
  <DataNode TextLabel="Vitamin D metabolism" GraphId="c58de" Type="Pathway">
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    <Xref Database="WikiPathways" ID="WP1531" />
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  <DataNode TextLabel="32-Oxolanosterol" GraphId="c6606" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010222" />
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  <DataNode TextLabel="Cyp7a1" GraphId="c79a2" Type="GeneProduct">
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    <Xref Database="Uniprot-TrEMBL" ID="Q64505" />
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  <DataNode TextLabel="Nr1h3" GraphId="c905a" Type="GeneProduct" GroupRef="b48a1">
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    <Xref Database="Ensembl" ID="ENSMUSG00000002108" />
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  <DataNode TextLabel="Soat1" GraphId="cb5b5" Type="GeneProduct" GroupRef="ddde4">
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    <Xref Database="Entrez Gene" ID="20652" />
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  <DataNode TextLabel="4α-formyl-5α-&#xA;cholesta-8-en-3β-ol" GraphId="d3ba6" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010231" />
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  <DataNode TextLabel="lanost-8-en-&#xA;3beta,30-diol" GraphId="d4b2b" Type="Metabolite">
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  <DataNode TextLabel="4α-formyl-5α-&#xA;cholesta-8,24-dien-3β-ol" GraphId="d9469" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010226" />
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  <DataNode TextLabel="4α-hydroxymethyl-4β-methyl-5α-&#xA;cholesta-8-en-3β-ol" GraphId="e02d9" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010233" />
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  <DataNode TextLabel="Fasn" GraphId="eb018" Type="GeneProduct" GroupRef="c86a4">
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    <Xref Database="Ensembl" ID="ENSMUSG00000025153" />
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  <DataNode TextLabel="4α-carboxy-5α-&#xA;cholesta-8-en-3β-ol" GraphId="eb3f3" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010228" />
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  <DataNode TextLabel="CE(16:1)" GraphId="ebb18" Type="Metabolite" GroupRef="c1e92">
    <Comment>Assuming this is omega-7 type</Comment>
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  <DataNode TextLabel="4α-hydroxymethyl-4β-methyl-&#xA;5α-cholesta-8,24-dien-3β-ol" GraphId="ec8bf" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010232" />
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  <DataNode TextLabel="Dhcr7" GraphId="ecff5" Type="GeneProduct">
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    <Xref Database="Entrez Gene" ID="13360" />
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  <DataNode TextLabel="3-keto-4alpha-methyl-zymosterol" GraphId="eeff5" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010237" />
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  <DataNode TextLabel="4α-hydroxymethyl-5α-&#xA;cholesta-8-en-3β-ol&#xA;" GraphId="f308d" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010235" />
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  <DataNode TextLabel="4α-hydroxymethyl-&#xA;5α-cholesta-8,24-dien-3β-ol" GraphId="f3bc3" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010234" />
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  <DataNode TextLabel="Dhcr24" GraphId="f5281" Type="Protein">
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    <Xref Database="Uniprot-TrEMBL" ID="Q8VCH6" />
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  <DataNode TextLabel="IPP" GraphId="fb47f" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMPR01010008" />
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  <DataNode TextLabel="4α-carboxyzymosterol" GraphId="fc9fd" Type="Metabolite">
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  <DataNode TextLabel="4α-formyl-4β-methyl-5α-&#xA;cholesta-8-en-3β-ol" GraphId="fe717" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010230" />
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  <DataNode TextLabel="Acetoacetyl-CoA" GraphId="a65cb" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMFA07050030" />
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  <DataNode TextLabel="HMG-CoA" GraphId="c2349" Type="Metabolite">
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  <DataNode TextLabel="Mevalonic acid" GraphId="de72d" Type="Metabolite">
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  <DataNode TextLabel="Mevalonate-5-P" GraphId="c3504" Type="Metabolite">
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  <DataNode TextLabel="Mevalonate-5-PP" GraphId="b33c5" Type="Metabolite">
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  <DataNode TextLabel="Isopentenyl-PP" GraphId="a17cf" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMPR01010008" />
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  <DataNode TextLabel="Dimethylallyl-PP" GraphId="c516a" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMPR01010001" />
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  <DataNode TextLabel="Geranyl-PP" GraphId="b67d7" Type="Metabolite">
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  <DataNode TextLabel="Farnesyl-PP" GraphId="e4be5" Type="Metabolite">
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  <DataNode TextLabel="Squalene" GraphId="c13fb" Type="Metabolite">
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  <DataNode TextLabel="Squalene-2,3-epoxide" GraphId="cd2cd" Type="Metabolite">
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  <DataNode TextLabel="32-hydroxylanosterol" GraphId="c7b83" Type="Metabolite">
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  <DataNode TextLabel="14-demethyl-lanosterol" GraphId="a1093" Type="Metabolite">
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  <DataNode TextLabel="Zymosterol" GraphId="f3008" Type="Metabolite">
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  <DataNode TextLabel="4-alpha-methyl-cholest-8-enone" GraphId="ae3c8" Type="Metabolite">
    <Comment></Comment>
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  <DataNode TextLabel="Zymostenol" GraphId="bd2e7" Type="Metabolite">
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  <DataNode TextLabel="Lathosterol" GraphId="c7972" Type="Metabolite">
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    <Xref Database="LIPID MAPS" ID="LMST01010089" />
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  <DataNode TextLabel="7-dehdrocholesterol" GraphId="b0510" Type="Metabolite">
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  <DataNode TextLabel="Cholestadienol" GraphId="f46e2" Type="Metabolite">
    <Comment>aka 24-dehydrolathosterol</Comment>
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    <Xref Database="LIPID MAPS" ID="LMST01010206" />
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  <DataNode TextLabel="7-dehydodesmosterol" GraphId="aa695" Type="Metabolite">
    <Graphics CenterX="812.9773577725687" CenterY="1403.9355806354793" Width="195.97159940209133" Height="24.50000000000003" ZOrder="32795" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010121" />
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  <DataNode TextLabel="Desmosterol" GraphId="e9838" Type="Metabolite">
    <Graphics CenterX="815.3929599035516" CenterY="1480.149956859883" Width="164.99999999999997" Height="29.26555491140214" ZOrder="32796" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010016" />
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  <DataNode TextLabel="Cholesterol" GraphId="d8c85" Type="Metabolite">
    <Graphics CenterX="990.158804606133" CenterY="1588.1565111699967" Width="165.0" Height="59.07172995780565" ZOrder="32797" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010001" />
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  <DataNode TextLabel="Sc5d" GraphId="f3d8e" Type="GeneProduct">
    <Graphics CenterX="925.634336905658" CenterY="1358.182903488067" Width="90.0" Height="25.0" ZOrder="32798" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="235293" />
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  <DataNode TextLabel="Ebp" GraphId="a3759" Type="GeneProduct">
    <Graphics CenterX="925.634336905658" CenterY="1279.8381780380796" Width="90.0" Height="25.0" ZOrder="32799" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13595" />
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  <DataNode TextLabel="Tm7fs2" GraphId="d362f" Type="GeneProduct" GroupRef="ae052">
    <Graphics CenterX="926.500137771459" CenterY="538.4548781855924" Width="62.03476415579898" Height="25.0" ZOrder="32802" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="73166" />
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  <DataNode TextLabel="7-oxocholesterol" GraphId="b065b" Type="Metabolite">
    <Graphics CenterX="1417.209789134963" CenterY="1588.7014034202848" Width="161.5" Height="20.5" ZOrder="32806" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010049" />
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  <DataNode TextLabel="Cholestenone" GraphId="df102" Type="Metabolite">
    <Graphics CenterX="1224.7620395720294" CenterY="1655.0684920278786" Width="161.5" Height="20.5" ZOrder="32807" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010015" />
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  <DataNode TextLabel="4beta-hydroxycholesterol" GraphId="f03cb" Type="Metabolite">
    <Graphics CenterX="1219.9017722573274" CenterY="1707.8054821825904" Width="161.5" Height="20.5" ZOrder="32808" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010014" />
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  <DataNode TextLabel="24S-hydroxycholesterol" GraphId="e3a1f" Type="Metabolite">
    <Graphics CenterX="791.0179355558706" CenterY="1755.9662268713187" Width="165.0" Height="24.5" ZOrder="32809" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010019" />
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  <DataNode TextLabel="25-hydroxycholesterol" GraphId="a2216" Type="Metabolite">
    <Graphics CenterX="778.8032374704701" CenterY="1572.603916603413" Width="165.0" Height="25.0" ZOrder="32810" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010018" />
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  <DataNode TextLabel="27-hydroxycholesterol" GraphId="bc76e" Type="Metabolite">
    <Graphics CenterX="990.1588046061331" CenterY="1755.3814315496809" Width="165.0" Height="24.5" ZOrder="32811" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010057" />
  </DataNode>
  <DataNode TextLabel="Cholesteryl esters (CE)" GraphId="acad3" Type="Metabolite" GroupRef="c1e92">
    <Graphics CenterX="554.6000778473783" CenterY="1802.3120556218435" Width="165.0" Height="24.5" ZOrder="32812" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMST01020000" />
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  <DataNode TextLabel="Cyp46a1" GraphId="e814e" Type="GeneProduct">
    <Graphics CenterX="947.5983634187775" CenterY="1704.8193433122078" Width="64.03938115330558" Height="24.999999999999968" ZOrder="32813" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13116" />
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  <DataNode TextLabel="Cyp27a1" GraphId="efca4" Type="GeneProduct">
    <Graphics CenterX="1037.599732876175" CenterY="1710.6672965285811" Width="64.03938115330558" Height="25.0" ZOrder="32814" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="104086" />
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  <DataNode TextLabel="Acyl-CoA" GraphId="c2bad" Type="Metabolite">
    <Graphics CenterX="683.7398710100404" CenterY="1631.1630326422592" Width="90.0" Height="25.0" ZOrder="32815" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA07050000" />
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  <DataNode TextLabel="Soat2" GraphId="c4546" Type="GeneProduct" GroupRef="ddde4">
    <Graphics CenterX="738.9230654070541" CenterY="1692.2246915052294" Width="67.3150492264409" Height="24.999999999999968" ZOrder="32816" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="223920" />
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  <DataNode TextLabel="Acat2" GraphId="a6a23" Type="GeneProduct" GroupRef="afa33">
    <Graphics CenterX="134.94445222311262" CenterY="209.4003810185491" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32817" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8CAY6" />
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  <DataNode TextLabel="Hmgcs1" GraphId="ff67e" Type="GeneProduct" GroupRef="e48eb">
    <Graphics CenterX="134.94445222311256" CenterY="268.19192913385785" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32819" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="208715" />
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  <DataNode TextLabel="Hmgcs2" GraphId="c4ec3" Type="GeneProduct" GroupRef="e48eb">
    <Graphics CenterX="134.94445222311256" CenterY="283.4412729658786" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32820" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="15360" />
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  <DataNode TextLabel="Mvk" GraphId="db6e1" Type="GeneProduct">
    <Graphics CenterX="134.9444522231126" CenterY="421.43456643263943" Width="64.5669291338582" Height="19.836614173228327" ZOrder="32821" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="17855" />
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  <DataNode TextLabel="Pmvk" GraphId="cf299" Type="GeneProduct">
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    <Xref Database="Entrez Gene" ID="68603" />
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  <DataNode TextLabel="Mvd" GraphId="cc32e" Type="GeneProduct">
    <Graphics CenterX="136.35092198401273" CenterY="562.1705773724474" Width="64.5669291338582" Height="19.836614173228327" ZOrder="32823" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="192156" />
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  <DataNode TextLabel="Sqle" GraphId="a6801" Type="GeneProduct">
    <Graphics CenterX="322.15739402752115" CenterY="240.4169243088217" Width="64.5669291338582" Height="19.836614173228327" ZOrder="32824" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="20775" />
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  <DataNode TextLabel="Idi1" GraphId="c0ff0" Type="GeneProduct" GroupRef="caab0">
    <Graphics CenterX="323.9751137355679" CenterY="641.2458396744502" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32826" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="319554" />
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  <DataNode TextLabel="Idi2" GraphId="e6e39" Type="GeneProduct" GroupRef="caab0">
    <Graphics CenterX="323.976426071526" CenterY="656.2451835064708" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32827" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="320581" />
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  <DataNode TextLabel="Fdft1" GraphId="b226c" Type="GeneProduct">
    <Graphics CenterX="332.13349443745483" CenterY="387.7059502736641" Width="64.5669291338582" Height="19.836614173228327" ZOrder="32828" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14137" />
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  <DataNode TextLabel="Ggps1" GraphId="f0820" Type="GeneProduct" GroupRef="fbff3">
    <Graphics CenterX="340.2646468952172" CenterY="525.5038561324461" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32830" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="14593" />
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  <DataNode TextLabel="Fdps" GraphId="d5ff3" Type="GeneProduct" GroupRef="fbff3">
    <Graphics CenterX="340.2646468952172" CenterY="539.4819969245482" Width="70.1843832020997" Height="15.899606299212564" ZOrder="32831" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="110196" />
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  <DataNode TextLabel="Lss" GraphId="f52aa" Type="GeneProduct">
    <Graphics CenterX="608.3619998114159" CenterY="202.17364967387633" Width="64.5669291338582" Height="19.836614173228327" ZOrder="32832" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="16987" />
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  <DataNode TextLabel="Kandutsch-&#xA;Russell &#xA;Pathway" GraphId="e6c4d" Type="Pathway">
    <Graphics CenterX="1186.7085165726826" CenterY="169.47445352376042" Width="85.07456939821117" Height="43.31047320705579" ZOrder="32833" FontWeight="Bold" FontSize="12" Valign="Middle" Color="009900" />
    <Xref Database="" ID="" />
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  <DataNode TextLabel="PreSqualene-PP" GraphId="f2a8e" Type="Metabolite">
    <Comment>Annotated while assuming this compound is actually presqualene-diphosphate</Comment>
    <Graphics CenterX="439.7980528663597" CenterY="387.7059502736641" Width="90.0" Height="25.0" ZOrder="32834" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMPR0106010003" />
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  <DataNode TextLabel="Dhcr7" GraphId="eb5a2" Type="GeneProduct">
    <Graphics CenterX="1051.5881295006477" CenterY="1436.590292309178" Width="90.0" Height="25.0" ZOrder="32841" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="13360" />
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  <DataNode TextLabel="Dhcr24" GraphId="d5bf1" Type="GeneProduct">
    <Graphics CenterX="990.4801226097786" CenterY="1489.415290852774" Width="90.0" Height="25.0" ZOrder="32842" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="74754" />
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  <DataNode TextLabel="CE(18:1)" GraphId="c9f8a" Type="Metabolite" GroupRef="c1e92">
    <Comment>Assuming this is omega-7 type</Comment>
    <Graphics CenterX="592.5747613916815" CenterY="1826.7455999256415" Width="90.0" Height="25.0" ZOrder="32844" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="Wikidata" ID="Q27116670" />
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  <DataNode TextLabel="Nr1h2" GraphId="ac50c" Type="GeneProduct" GroupRef="b48a1">
    <Graphics CenterX="404.24518781927253" CenterY="1572.603916603413" Width="50.75236248074137" Height="25.0" ZOrder="32845" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000060601" />
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  <DataNode TextLabel="Abcg1" GraphId="cf0ab" Type="GeneProduct" GroupRef="f46e6">
    <Graphics CenterX="467.84939305598266" CenterY="1682.5454370712473" Width="90.0" Height="25.0" ZOrder="32850" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024030" />
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  <DataNode TextLabel="Mylip (IDOL)" GraphId="e201b" Type="GeneProduct">
    <Graphics CenterX="377.8493930559826" CenterY="1759.2705832700785" Width="90.0" Height="25.0" ZOrder="32851" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038175" />
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  <DataNode TextLabel="Srebf2" GraphId="f84f3" Type="GeneProduct">
    <Graphics CenterX="162.6407604793326" CenterY="1572.603916603413" Width="59.79517279570178" Height="25.0" ZOrder="32854" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000022463" />
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  <DataNode TextLabel="Acsl1" GraphId="ba146" Type="GeneProduct" GroupRef="c86a4">
    <Graphics CenterX="202.38786034738504" CenterY="1809.723352111406" Width="46.77567327611733" Height="25.0" ZOrder="32859" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000018796" />
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  <DataNode TextLabel="Acsl3" GraphId="cd78e" Type="GeneProduct" GroupRef="c86a4">
    <Graphics CenterX="249.16353362350247" CenterY="1809.723352111406" Width="46.77567327611733" Height="25.0" ZOrder="32860" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032883" />
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  <DataNode TextLabel="Acsl4" GraphId="eccbc" Type="GeneProduct" GroupRef="c86a4">
    <Graphics CenterX="155.6121870712674" CenterY="1834.7233521114063" Width="46.77567327611733" Height="25.0" ZOrder="32861" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000031278" />
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  <DataNode TextLabel="Elovl2" GraphId="c4de4" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="202.3878603473851" CenterY="1834.7233521114063" Width="46.77567327611733" Height="25.0" ZOrder="32862" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021364" />
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  <DataNode TextLabel="Elovl3" GraphId="b4459" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="249.16353362350242" CenterY="1834.7233521114063" Width="46.77567327611733" Height="25.0" ZOrder="32863" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
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  <DataNode TextLabel="Elovl4" GraphId="f2c1a" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="155.6121870712674" CenterY="1859.7233521114063" Width="46.77567327611733" Height="25.0" ZOrder="32864" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032262" />
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  <DataNode TextLabel="Elovl5" GraphId="e41d4" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="202.3878603473851" CenterY="1859.7233521114063" Width="46.77567327611733" Height="25.0" ZOrder="32865" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
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  <DataNode TextLabel="Fads1" GraphId="d8359" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="249.16353362350242" CenterY="1859.4274065653867" Width="46.77567327611733" Height="25.0" ZOrder="32866" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000010663" />
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  <DataNode TextLabel="Fads2" GraphId="c2c3d" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="155.61218707126736" CenterY="1884.7233521114065" Width="46.77567327611733" Height="25.0" ZOrder="32867" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
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  <DataNode TextLabel="Scd1" GraphId="c2197" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="202.38786034738504" CenterY="1884.7233521114065" Width="46.77567327611733" Height="25.0" ZOrder="32868" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000037071" />
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  <DataNode TextLabel="Scd2" GraphId="a743a" Type="Protein" GroupRef="c86a4">
    <Graphics CenterX="249.16353362350247" CenterY="1884.7233521114065" Width="46.77567327611733" Height="25.0" ZOrder="32869" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P13011" />
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  <DataNode TextLabel="Acot1" GraphId="c48d2" Type="GeneProduct" GroupRef="c86a4">
    <Graphics CenterX="155.61218707126736" CenterY="1909.7233521114065" Width="46.77567327611733" Height="25.0" ZOrder="32870" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000072949" />
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  <DataNode TextLabel="Acot2" GraphId="bde89" Type="GeneProduct" GroupRef="c86a4">
    <Graphics CenterX="202.3878603473851" CenterY="1909.7233521114065" Width="46.77567327611733" Height="25.0" ZOrder="32871" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021226" />
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  <DataNode TextLabel="Fatty acid biosynthesis" GraphId="d2b5e" Type="Pathway">
    <Graphics CenterX="105.19509489958646" CenterY="1776.911588548296" Width="154.32536108931555" Height="25.0" ZOrder="32872" FontWeight="Bold" FontSize="12" Valign="Middle" Color="14961e" />
    <Xref Database="WikiPathways" ID="WP4491" />
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  <DataNode TextLabel="Oleic acid" GraphId="ef1cc" Type="Metabolite" GroupRef="f4bff">
    <Comment>Aka C18:1 (omega 9)</Comment>
    <Graphics CenterX="375.74604691830075" CenterY="1907.68106211171" Width="65.13530135301335" Height="25.0" ZOrder="32873" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030002" />
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  <DataNode TextLabel="4alpha-methylcholest-8-en-3beta-ol" GraphId="e68a6" Type="Metabolite">
    <Comment></Comment>
    <Graphics CenterX="1197.774417108411" CenterY="940.5615678516255" Width="203.32480818414282" Height="24.5" ZOrder="32874" FontSize="12" Valign="Middle" Color="0033ff" />
    <Xref Database="LIPID MAPS" ID="LMST01010197" />
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  <DataNode TextLabel="4-methyl-4-carboxy&#xA;zymostenone" GraphId="dfc66" Type="Metabolite">
    <Comment>C12CC[C@@]3([H])C(C)(COOH)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC[C]21H</Comment>
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    <Xref Database="LIPID MAPS" ID="LMST01010227" />
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  <DataNode TextLabel="4,4-dimethylcholesta-8,14-dienol" GraphId="de222" Type="Metabolite">
    <Comment>C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/CC(\C)/C)CC=[C@@]21C</Comment>
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    <Xref Database="LIPID MAPS" ID="LMST01010277" />
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  <DataNode TextLabel="Cyp51A1" GraphId="fc99e" Type="Protein">
    <Graphics CenterX="1397.8738699385874" CenterY="345.6877076641265" Width="90.0" Height="25.0" ZOrder="32884" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8K0C4" />
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  <DataNode TextLabel="Tm7sf2" GraphId="a2acf" Type="Protein" GroupRef="b1f6a">
    <Graphics CenterX="1372.6015552581205" CenterY="519.169325951241" Width="90.0" Height="25.0" ZOrder="32886" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q71KT5" />
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  <DataNode TextLabel="Msmo1" GraphId="e2406" Type="Protein">
    <Graphics CenterX="953.815602604062" CenterY="688.0844488967203" Width="62.85657138325108" Height="25.0" ZOrder="32888" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q9CRA4" />
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  <DataNode TextLabel="Lbr" GraphId="f3766" Type="Protein" GroupRef="b1f6a">
    <Graphics CenterX="1372.6015552581205" CenterY="544.1693259512411" Width="90.0" Height="25.0" ZOrder="32892" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q3U9G9" />
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  <DataNode TextLabel="Cyp51A1" GraphId="de415" Type="Protein">
    <Graphics CenterX="655.655914454366" CenterY="342.2256236082434" Width="90.0" Height="25.0" ZOrder="32917" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q8K0C4" />
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  <DataNode TextLabel="Hsd17b7" GraphId="e64ce" Type="Protein">
    <Graphics CenterX="925.634336905658" CenterY="906.3052731368674" Width="59.80733029781916" Height="24.999999999999996" ZOrder="32918" FontSize="12" Valign="Middle" />
    <Xref Database="Entrez Gene" ID="15490" />
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  <DataNode TextLabel="IPP" GraphId="fc9ee" Type="Metabolite">
    <Graphics CenterX="491.0153800829093" CenterY="570.1792665470953" Width="38.415637860082334" Height="13.323045267489626" ZOrder="32934" FontSize="12" Valign="Middle" Color="0000ff" />
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    <Comment> EC:2.5.1.1</Comment>
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    <Comment>EC:1.14.14.23</Comment>
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    <Comment>EC:1.14.14.17</Comment>
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    <Comment>EC:1.14.18.9 </Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Comment>EC:1.1.1.270</Comment>
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    <Comment>EC:1.14.14.25</Comment>
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    <Comment>EC:2.3.3.10</Comment>
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    <Comment>EC:5.3.3.5</Comment>
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    <Comment>EC:5.3.3.2</Comment>
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  <Interaction GraphId="id7b16c8a0">
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  <Interaction GraphId="id7ed85df8">
    <Comment>EC:1.1.1.170</Comment>
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  <Interaction GraphId="id84c482b9">
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    <Comment>EC:1.1.1.170</Comment>
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    <Comment>EC:1.1.1.270</Comment>
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    <Comment>EC:2.5.1.10</Comment>
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  <Interaction GraphId="id8c808d63">
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    <Comment>EC:1.14.18.9 </Comment>
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    <Comment>EC:1.14.18.9</Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Comment>EC:1.14.14.154</Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Comment>EC:1.1.1.170</Comment>
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  <Interaction GraphId="id91f4cea8">
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    <Comment>EC:1.14.18.9</Comment>
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    <Comment>EC:2.3.1.9</Comment>
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    <Comment>EC:1.14.18.9</Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Comment>EC:1.14.18.9</Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Comment>EC:1.14.14.154</Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Comment>EC:1.3.1.70</Comment>
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    <Xref Database="Rhea" ID="18563" />
  </Interaction>
  <Interaction GraphId="idae71aeb2">
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    <Comment>EC:1.14.18.9 </Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Xref Database="Rhea" ID="46477" />
  </Interaction>
  <Interaction GraphId="idb27ed89f">
    <Graphics ZOrder="12288" LineThickness="1.0">
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  <Interaction GraphId="idb3de7a39">
    <Graphics ZOrder="12288" LineThickness="1.0">
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  <Interaction GraphId="idb494995e">
    <Comment>EC:5.4.99.7</Comment>
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      <Point X="722.8340677768567" Y="237.31133424670992" GraphRef="ac635" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
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    <Xref Database="Rhea" ID="14622" />
  </Interaction>
  <Interaction GraphId="idbc84aa81">
    <Graphics ZOrder="12288" LineThickness="1.0">
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    <Xref Database="" ID="" />
  </Interaction>
  <Interaction GraphId="idbcfb150e">
    <Graphics ZOrder="12288" LineThickness="1.0">
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  <Interaction GraphId="idbf581684">
    <Comment>EC:2.7.1.36</Comment>
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      <Point X="232.17207748008173" Y="452.5" GraphRef="c3504" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" />
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    <Xref Database="Rhea" ID="17066" />
  </Interaction>
  <Interaction GraphId="idc0f88a18">
    <Graphics ZOrder="12288" LineThickness="1.0">
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  <Interaction GraphId="idc1078c90">
    <Comment>EC:1.3.1.72</Comment>
    <BiopaxRef>ee1</BiopaxRef>
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    <Xref Database="Rhea" ID="36393" />
  </Interaction>
  <Interaction GraphId="idc228d2e4">
    <Graphics ZOrder="12288" LineThickness="1.0">
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  <Interaction GraphId="idc3892106">
    <Comment>EC:1.14.99.38</Comment>
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    <Xref Database="Rhea" ID="46133" />
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  <Interaction GraphId="idc477ee2a">
    <Comment>From the LipidMaps drawing, it is unclear if only Nr1h3 influences Srebf1, or the group Nr1h2/3 does this.</Comment>
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  <Interaction GraphId="idc7299d04">
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  <Interaction GraphId="idcb91214">
    <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
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  <Interaction GraphId="idcca7a0a1">
    <Comment>EC:1.3.1.21</Comment>
    <BiopaxRef>ee1</BiopaxRef>
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    <Xref Database="Rhea" ID="23986" />
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  <Interaction GraphId="idcd507b5e">
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  <Interaction GraphId="idce36e2f4">
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  <Interaction GraphId="idcf685ec9">
    <BiopaxRef>ee1</BiopaxRef>
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  <Interaction GraphId="idd1adf419">
    <Comment>EC:1.14.14.154</Comment>
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  </Interaction>
  <Interaction GraphId="idd4ddcb4a">
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  <Interaction GraphId="idd5b4b329">
    <Comment>EC:2.3.1.26</Comment>
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    <Xref Database="Rhea" ID="17730" />
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  <Interaction GraphId="idd6447906">
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  <Interaction GraphId="idd80c8fa5">
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  <Interaction GraphId="idd9f102da">
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  <Interaction GraphId="idda028e3c">
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  <Interaction GraphId="iddb4f5612">
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  <Interaction GraphId="iddf348d19">
    <Comment>EC:1.3.1.72 </Comment>
    <BiopaxRef>ee1</BiopaxRef>
    <BiopaxRef>a2a</BiopaxRef>
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    <Xref Database="Rhea" ID="33920" />
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  <Interaction GraphId="ide1f6c7fb">
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  <Interaction GraphId="ide3a40b5d">
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  <Interaction GraphId="ide48549e2">
    <Comment>EC:2.3.3.10</Comment>
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  <Interaction GraphId="ide48aa9b2">
    <Comment> EC:2.5.1.1</Comment>
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  <Interaction GraphId="ide58e0538">
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    <Comment>EC:1.14.18.9 </Comment>
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    <Xref Database="Rhea" ID="46837" />
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  <Interaction GraphId="ide7db421a">
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  <Interaction GraphId="ide9a1be76">
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  <Interaction GraphId="idee42014b">
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    <BiopaxRef>ee1</BiopaxRef>
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    <Comment>EC:5.3.3.5</Comment>
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    <Xref Database="Rhea" ID="34000" />
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  <Interaction GraphId="idf4b93348">
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    <Comment>EC:1.14.18.9</Comment>
    <BiopaxRef>a86</BiopaxRef>
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    <Xref Database="Rhea" ID="46825" />
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    <Comment>EC:2.5.1.103</Comment>
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