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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Wnt signaling in kidney disease" Data-Source="WikiPathways" Version="WP3857_r129329" Author="[AAR&amp;amp;Co, Mkutmon, AlexanderPico, Khanspers, MaintBot, AgustinGV, Eweitz]" Last-Modified="20240326140922" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling.  Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects.</Comment>
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