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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Spinal cord injury" Data-Source="WikiPathways" Version="WP2432_r116842" Author="[Nsalomonis, Egonw, MaintBot, DMicael, Evelo, Lindarieswijk, Eweitz]" Last-Modified="20210514103255" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants  and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.</Comment>
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