<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Elongation of (very) long chain fatty acids" Data-Source="WikiPathways" Version="WP4491_r125976" Author="[DeSl, MaintBot, Egonw, Conroy lipids, AlexanderPico]" Last-Modified="20230323155803" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">This pathway depicts the key steps in (very) long-chain fatty acid biosynthesis, belonging to the n-10, 9 and 7 series (counting first double bond from the methyl side).
These are mainly synthesised from palmitic acid (C16:0), which is produced by FAS (fatty acid synthase). 
The n-6 and 3 series can only be obtained from precursors in food.
The elongation steps (addition of carbohydrates, increasing length of tail) are carried out by several Elovl-proteins.
The desaturation (removal of hydrogens, creating double bonds within the tail) are possible by SCDs and Fads (where is position of the double bound addition is indicated after delta, counting from the COOH side).</Comment>
  <BiopaxRef>ded</BiopaxRef>
  <Graphics BoardWidth="1366.1462728551337" BoardHeight="1021.2904009720529" />
  <DataNode TextLabel="C18:2" GraphId="c1e5e" Type="Metabolite">
    <Comment>AKA Linoleic Acid</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA01030120" />
  </DataNode>
  <DataNode TextLabel="C16:1" GraphId="d76d1" Type="Metabolite">
    <Comment>CCCCCCCCCC=CCCCCC(=O)O C16:1 (omega-10)</Comment>
    <Comment>AKA Sapienic acid</Comment>
    <Graphics CenterX="472.0" CenterY="120.69866342648851" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030267" />
  </DataNode>
  <DataNode TextLabel="C18:2" GraphId="da6e8" Type="Metabolite">
    <Comment>CCCCCCC=CCC=CCCCCCCC(=O)O C18:2 (omega-7)(delta6)</Comment>
    <Comment>8Z,11Z-octadecadienoic acid</Comment>
    <Graphics CenterX="755.0" CenterY="273.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030116" />
  </DataNode>
  <DataNode TextLabel="Fads2" GraphId="de596" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
  </DataNode>
  <DataNode TextLabel="C20:2" GraphId="e8bf3" Type="Metabolite">
    <Comment>CCCCCC=CCC=CCCCCCCCCCC(=O)O dihomoLinoleic Acid; C20:2 (omega 6)</Comment>
    <Graphics CenterX="457.0833333333331" CenterY="648.148148148148" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01031043" />
  </DataNode>
  <DataNode TextLabel="Elovl6" GraphId="eea01" Type="Protein" GroupRef="e060c">
    <Graphics CenterX="549.5" CenterY="168.9540775534679" Width="57.0" Height="20.5" ZOrder="32768" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000041220" />
  </DataNode>
  <DataNode TextLabel="Fas" GraphId="f1afe" Type="GeneProduct">
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    <Xref Database="Ensembl" ID="ENSMUSG00000025153" />
  </DataNode>
  <DataNode TextLabel="Excess carbohydrates" GraphId="f1e13" Type="Metabolite">
    <Graphics CenterX="174.89814814814824" CenterY="98.0" Width="132.20370370370387" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="Wikidata" ID="Q11358" />
  </DataNode>
  <DataNode TextLabel="C18:1" GraphId="b8cff" Type="Metabolite">
    <Comment>CCCCCCCCCC=CCCCCCCC(=O)O C18:1 (omega-10)</Comment>
    <Comment>cis-8-oleic acid, 
cis-8-octadecenoic acid</Comment>
    <Graphics CenterX="626.0" CenterY="120.69866342648851" Width="90.0" Height="25.0" ZOrder="32769" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030070" />
  </DataNode>
  <DataNode TextLabel="C16:0" GraphId="d575d" Type="Metabolite">
    <Comment>AKA Palmitic Acid</Comment>
    <Graphics CenterX="305.9781287970835" CenterY="221.0" Width="90.0" Height="25.0" ZOrder="32770" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010001" />
  </DataNode>
  <DataNode TextLabel="C18:0" GraphId="f2e95" Type="Metabolite">
    <Comment>AKA Stearic acid</Comment>
    <Graphics CenterX="305.9781287970835" CenterY="381.9075630252102" Width="90.0" Height="25.0" ZOrder="32771" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010018" />
  </DataNode>
  <DataNode TextLabel="C20:0" GraphId="cfab0" Type="Metabolite">
    <Comment>AKA Arachidic acid</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA01010020" />
  </DataNode>
  <DataNode TextLabel="C16:1" GraphId="d8cdc" Type="Metabolite">
    <Comment>CCCCCCCCC=CCCCCCC(=O)O C16:1 (omega-9)</Comment>
    <Comment>AKA Palmitoleic acid</Comment>
    <Graphics CenterX="474.0" CenterY="221.0" Width="90.0" Height="25.0" ZOrder="32776" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030056" />
  </DataNode>
  <DataNode TextLabel="C18:1" GraphId="db6dd" Type="Metabolite">
    <Comment>CCCCCCCCC=CCCCCCCCC(=O)O C18:1 (omega-9)</Comment>
    <Comment>AKA Vaccenic acid</Comment>
    <Graphics CenterX="627.2503002400241" CenterY="220.8001199280432" Width="90.0" Height="25.0" ZOrder="32777" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030076" />
  </DataNode>
  <DataNode TextLabel="C16:2" GraphId="e5b46" Type="Metabolite">
    <Comment>CCCCCCC=CCC=CCCCCC(=O)O C16:2 (omega-7)(delta6)</Comment>
    <Comment>6Z,9Z-hexadecadienoic acid</Comment>
    <Graphics CenterX="629.0" CenterY="273.0" Width="90.0" Height="25.0" ZOrder="32778" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030273" />
  </DataNode>
  <DataNode TextLabel="C18:3" GraphId="f3d38" Type="Metabolite">
    <Comment>Existance of this lipids in samples is uncertain; not part of LIPID MAPS, therefore not annotated</Comment>
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    <Xref Database="" ID="" />
  </DataNode>
  <DataNode TextLabel="C20:3" GraphId="fe676" Type="Metabolite">
    <Graphics CenterX="1028.0" CenterY="273.0" Width="90.0" Height="25.0" ZOrder="32780" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030384" />
  </DataNode>
  <DataNode TextLabel="C18:2" GraphId="ba729" Type="Metabolite">
    <Comment>CCCCCCCCC=CCC=CCCCCC(=O)O C18:2 (omega-9)(delta6)</Comment>
    <Comment>6Z,9Z-octadecadienoic acid</Comment>
    <Graphics CenterX="626.0" CenterY="362.76783033991256" Width="90.0" Height="25.0" ZOrder="32781" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030332" />
  </DataNode>
  <DataNode TextLabel="C20:2" GraphId="e3374" Type="Metabolite">
    <Comment>CCCCCCCCC=CCC=CCCCCCCC(=O)O C20:2 (omega-9)(delta6)</Comment>
    <Graphics CenterX="755.0" CenterY="362.76783033991256" Width="90.0" Height="25.0" ZOrder="32782" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030377" />
  </DataNode>
  <DataNode TextLabel="C20:3" GraphId="f041c" Type="Metabolite">
    <Comment>AKA Mead acid</Comment>
    <Comment>CCCCCCCCC=CCC=CCC=CCCCCCC(=O)O C20:2 (omega-9)(delta6)(delta5)</Comment>
    <Graphics CenterX="881.9495798319327" CenterY="362.76783033991256" Width="90.0" Height="25.0" ZOrder="32783" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030381" />
  </DataNode>
  <DataNode TextLabel="C22:3" GraphId="d6a76" Type="Metabolite">
    <Comment>C(CCCCC/C=C\C/C=C\C/C=C\CCCCCCCC)(=O)O</Comment>
    <Comment>Dihomo Mead's acid</Comment>
    <Graphics CenterX="1028.0" CenterY="362.76783033991256" Width="90.0" Height="25.0" ZOrder="32784" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030411" />
  </DataNode>
  <DataNode TextLabel="C18:1" GraphId="a867f" Type="Metabolite">
    <Comment>AKA oleic acid</Comment>
    <Graphics CenterX="474.0" CenterY="381.9075630252102" Width="90.0" Height="25.0" ZOrder="32790" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030002" />
  </DataNode>
  <DataNode TextLabel="C20:1" GraphId="e8ad5" Type="Metabolite">
    <Comment>cis-gondoic acid</Comment>
    <Comment>C20:1 (omega-9) aka eicosenoic acid</Comment>
    <Graphics CenterX="626.0" CenterY="409.32676108110314" Width="90.0" Height="25.0" ZOrder="32793" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030085" />
  </DataNode>
  <DataNode TextLabel="C22:1" GraphId="b9353" Type="Metabolite">
    <Comment>AKA Erucic acid</Comment>
    <Comment>CCCCCCCCC=CCCCCCCCCCCCC(=O)O C22:1 (omega-9)</Comment>
    <Graphics CenterX="755.0" CenterY="409.32676108110314" Width="90.0" Height="25.0" ZOrder="32794" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030089" />
  </DataNode>
  <DataNode TextLabel="C24:1" GraphId="a3661" Type="Metabolite">
    <Comment>CCCCCCCCC=CCCCCCCCCCCCCCC(=O)O C24:1 (omega-9)</Comment>
    <Comment>Nervonic acid</Comment>
    <Graphics CenterX="881.9495798319327" CenterY="409.32676108110314" Width="90.0" Height="25.0" ZOrder="32795" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030092" />
  </DataNode>
  <DataNode TextLabel="C22:0" GraphId="f79ec" Type="Metabolite">
    <Comment>AKA Behenic Acid</Comment>
    <Graphics CenterX="474.0" CenterY="483.9075630252102" Width="90.0" Height="25.0" ZOrder="32801" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010022" />
  </DataNode>
  <DataNode TextLabel="C24:0" GraphId="a81a8" Type="Metabolite">
    <Comment>AKA Lignoceric acid</Comment>
    <Graphics CenterX="626.0" CenterY="483.9075630252102" Width="90.0" Height="25.0" ZOrder="32802" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010024" />
  </DataNode>
  <DataNode TextLabel="C26:0" GraphId="eb9f0" Type="Metabolite">
    <Comment>Cerotic acid</Comment>
    <Graphics CenterX="755.0" CenterY="483.9075630252102" Width="90.0" Height="25.0" ZOrder="32803" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010026" />
  </DataNode>
  <DataNode TextLabel="C28:0" GraphId="b8159" Type="Metabolite">
    <Comment>AKA montanic acid (not mentioned in main article).</Comment>
    <Graphics CenterX="881.9495798319327" CenterY="483.9075630252102" Width="90.0" Height="25.0" ZOrder="32804" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010028" />
  </DataNode>
  <DataNode TextLabel="C30:0" GraphId="ef0be" Type="Metabolite">
    <Comment>AKA melissic acid or triacontanoic acid not mentioned in main article).</Comment>
    <Graphics CenterX="1028.0" CenterY="483.9075630252102" Width="90.0" Height="25.0" ZOrder="32805" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01010030" />
  </DataNode>
  <DataNode TextLabel="Elovl5" GraphId="e91da" Type="Protein" GroupRef="e060c">
    <Graphics CenterX="549.5" CenterY="189.4540775534679" Width="57.0" Height="20.5" ZOrder="32811" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
  </DataNode>
  <DataNode TextLabel="Elovl5" GraphId="c0b04" Type="GeneProduct">
    <Graphics CenterX="688.2970838396103" CenterY="332.57792247418234" Width="57.0" Height="20.5" ZOrder="32814" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
  </DataNode>
  <DataNode TextLabel="Fads1" GraphId="ac5fa" Type="Protein">
    <Graphics CenterX="816.4249117630036" CenterY="332.57792247418246" Width="50.73511543134914" Height="20.498881900374826" ZOrder="32815" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000010663" />
  </DataNode>
  <DataNode TextLabel="Elovl3" GraphId="fb437" Type="Protein">
    <Graphics CenterX="688.2970838396104" CenterY="435.20246682412176" Width="57.0" Height="20.5" ZOrder="32816" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
  </DataNode>
  <DataNode TextLabel="Elovl3" GraphId="c46b0" Type="Protein">
    <Graphics CenterX="817.3736330498173" CenterY="435.20246682412164" Width="57.0" Height="20.5" ZOrder="32817" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
  </DataNode>
  <DataNode TextLabel="Elovl3" GraphId="ddd3d" Type="Protein">
    <Graphics CenterX="473.99999999999994" CenterY="434.2668653660417" Width="57.0" Height="20.5" ZOrder="32818" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
  </DataNode>
  <DataNode TextLabel="SCD3" GraphId="bbc04" Type="Protein">
    <Graphics CenterX="380.6713244228432" CenterY="187.25" Width="50.73511543134913" Height="18.5" ZOrder="32819" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q99PL7" />
  </DataNode>
  <DataNode TextLabel="SCD1" GraphId="cbf41" Type="Protein" GroupRef="e5d86">
    <Graphics CenterX="380.6713244228432" CenterY="256.8526731470244" Width="50.735115431349136" Height="20.294653705951195" ZOrder="32820" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000037071" />
  </DataNode>
  <DataNode TextLabel="SCD2" GraphId="f11eb" Type="Protein" GroupRef="e5d86">
    <Graphics CenterX="380.6713244228432" CenterY="276.1473268529748" Width="50.735115431349136" Height="18.294653705949603" ZOrder="32821" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P13011" />
  </DataNode>
  <DataNode TextLabel="SCD4" GraphId="ab83a" Type="Protein" GroupRef="e5d86">
    <Graphics CenterX="380.6713244228432" CenterY="294.4419805589244" Width="50.735115431349136" Height="18.2946537059496" ZOrder="32822" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q6T707" />
  </DataNode>
  <DataNode TextLabel="Fads2 ?" GraphId="ec847" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
  </DataNode>
  <DataNode TextLabel="Fads2" GraphId="c9329" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
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  <DataNode TextLabel="SCD2" GraphId="d4048" Type="Protein" GroupRef="e484d">
    <Graphics CenterX="381.7831616243084" CenterY="413.35267314702617" Width="50.73511543134913" Height="18.2946537059496" ZOrder="32825" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="P13011" />
  </DataNode>
  <DataNode TextLabel="SCD4" GraphId="ada5d" Type="Protein" GroupRef="e484d">
    <Graphics CenterX="381.7831616243084" CenterY="431.64732685297577" Width="50.73511543134913" Height="18.2946537059496" ZOrder="32826" FontSize="12" Valign="Middle" />
    <Xref Database="Uniprot-TrEMBL" ID="Q6T707" />
  </DataNode>
  <DataNode TextLabel="SCD1" GraphId="f22e9" Type="Protein">
    <Graphics CenterX="382.57535966999154" CenterY="354.60019451279896" Width="45.150719339983084" Height="19.20038902559793" ZOrder="32827" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000037071" />
  </DataNode>
  <DataNode TextLabel="Elovl3" GraphId="e4e8c" Type="GeneProduct" GroupRef="c2d67">
    <Graphics CenterX="229.85170568834974" CenterY="433.6856601014327" Width="57.0" Height="20.5" ZOrder="32829" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
  </DataNode>
  <DataNode TextLabel="Elovl1" GraphId="b0558" Type="GeneProduct" GroupRef="c2d67">
    <Graphics CenterX="229.85170568834974" CenterY="413.1856601014327" Width="57.0" Height="20.5" ZOrder="32830" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000006390" />
  </DataNode>
  <DataNode TextLabel="Elovl7" GraphId="e6e5b" Type="GeneProduct" GroupRef="c2d67">
    <Graphics CenterX="229.85170568834974" CenterY="454.1856601014327" Width="57.0" Height="20.5" ZOrder="32831" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021696" />
  </DataNode>
  <DataNode TextLabel="Elovl6" GraphId="cf393" Type="GeneProduct">
    <Graphics CenterX="229.85170568834974" CenterY="290.8327189249621" Width="57.0" Height="20.5" ZOrder="32832" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000041220" />
  </DataNode>
  <DataNode TextLabel="Elovl3" GraphId="f0613" Type="Protein" GroupRef="b4e48">
    <Graphics CenterX="381.65842837742537" CenterY="540.9629710258027" Width="57.0" Height="20.5" ZOrder="32833" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
  </DataNode>
  <DataNode TextLabel="Elovl1" GraphId="fe7e0" Type="Protein" GroupRef="b4e48">
    <Graphics CenterX="381.6584283774254" CenterY="520.4629710258029" Width="57.0" Height="20.5" ZOrder="32834" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000006390" />
  </DataNode>
  <DataNode TextLabel="Elovl7" GraphId="a3826" Type="Protein" GroupRef="b4e48">
    <Graphics CenterX="381.6584283774253" CenterY="561.4629710258026" Width="57.0" Height="20.5" ZOrder="32835" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021696" />
  </DataNode>
  <DataNode TextLabel="Elovl3" GraphId="d91ba" Type="Protein" GroupRef="c2259">
    <Graphics CenterX="543.9693527471733" CenterY="564.5217945552139" Width="57.0" Height="20.5" ZOrder="32836" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
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  <DataNode TextLabel="Elovl1" GraphId="d0e62" Type="Protein" GroupRef="c2259">
    <Graphics CenterX="543.9693527471733" CenterY="544.0217945552139" Width="57.0" Height="20.5" ZOrder="32837" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000006390" />
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  <DataNode TextLabel="Elovl7" GraphId="da281" Type="Protein" GroupRef="c2259">
    <Graphics CenterX="543.9693527471733" CenterY="585.0217945552139" Width="57.0" Height="20.5" ZOrder="32838" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021696" />
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  <DataNode TextLabel="Elovl3" GraphId="c8c96" Type="Protein" GroupRef="ec2ca">
    <Graphics CenterX="686.3222939236437" CenterY="569.2696937148775" Width="57.0" Height="20.5" ZOrder="32839" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000038754" />
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  <DataNode TextLabel="Elovl1" GraphId="d935d" Type="Protein" GroupRef="ec2ca">
    <Graphics CenterX="686.3222939236437" CenterY="548.7696937148775" Width="57.0" Height="20.5" ZOrder="32840" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000006390" />
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  <DataNode TextLabel="Elovl4" GraphId="b7d96" Type="GeneProduct">
    <Graphics CenterX="881.9495798319329" CenterY="553.5175928745414" Width="57.0" Height="20.5" ZOrder="32841" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032262" />
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  <DataNode TextLabel="C18:3" GraphId="dd584" Type="Metabolite">
    <Comment>AKA alpha-linolenic acid</Comment>
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    <Xref Database="LIPID MAPS" ID="LMFA01030152" />
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  <DataNode TextLabel="C18:3" GraphId="f8754" Type="Metabolite">
    <Comment>CCCCCC=CCC=CCC=CCCCCC(=O)O gammaLinoleic Acid; C18:3 (omega 6)(delta6)</Comment>
    <Graphics CenterX="457.0833333333331" CenterY="716.2499999999997" Width="90.0" Height="25.0" ZOrder="32845" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030141" />
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  <DataNode TextLabel="C18:3" GraphId="cc575" Type="Metabolite">
    <Comment>Pinolenic acid</Comment>
    <Graphics CenterX="457.0833333333331" CenterY="776.944444444443" Width="90.0" Height="25.0" ZOrder="32846" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030344" />
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  <DataNode TextLabel="C20:3" GraphId="ecc43" Type="Metabolite">
    <Comment>bishomo-gamma-linolenic acid</Comment>
    <Graphics CenterX="583.0833333333329" CenterY="716.2499999999998" Width="90.0" Height="25.0" ZOrder="32847" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030158" />
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  <DataNode TextLabel="C20:3" GraphId="ddae5" Type="Metabolite">
    <Comment>Bishomopinolenic acid</Comment>
    <Graphics CenterX="582.0833333333329" CenterY="776.944444444443" Width="90.0" Height="25.0" ZOrder="32848" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030386" />
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  <DataNode TextLabel="C20:4" GraphId="e9624" Type="Metabolite">
    <Comment>AKA arachidonic acid</Comment>
    <Comment></Comment>
    <Graphics CenterX="729.9682061579645" CenterY="716.2499999999997" Width="90.0" Height="25.0" ZOrder="32849" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030001" />
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  <DataNode TextLabel="C22:4" GraphId="d375a" Type="Metabolite">
    <Comment>Adrenic acid</Comment>
    <Graphics CenterX="855.7089468987053" CenterY="716.2499999999997" Width="90.0" Height="25.0" ZOrder="32850" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030178" />
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  <DataNode TextLabel="C24:4" GraphId="dd8eb" Type="Metabolite">
    <Comment>9Z,12Z,15Z,18Z-Tetracosatetraenoic acid</Comment>
    <Graphics CenterX="982.6070950468529" CenterY="717.3004201680668" Width="90.0" Height="25.0" ZOrder="32851" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030819" />
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  <DataNode TextLabel="C24:5" GraphId="d9d87" Type="Metabolite">
    <Comment>6Z,9Z,12Z,15Z,18Z-tetracosapentaenoic acid</Comment>
    <Graphics CenterX="1110.6626506024086" CenterY="716.2499999999997" Width="90.0" Height="25.0" ZOrder="32852" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030820" />
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  <DataNode TextLabel="C22:5" GraphId="b9e59" Type="Metabolite">
    <Comment>AKA Docosapentaenoic acid</Comment>
    <Comment></Comment>
    <Graphics CenterX="1240.6163543061118" CenterY="716.2499999999997" Width="90.0" Height="25.0" ZOrder="32853" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA04000064" />
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  <DataNode TextLabel="C34:5" GraphId="a26e6" Type="Metabolite">
    <Comment>16Z,19Z,22Z,25Z,28Z-tetratriacontapentaenoic acid</Comment>
    <Graphics CenterX="1240.6163543061118" CenterY="643.950245426149" Width="90.0" Height="25.0" ZOrder="32854" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030849" />
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  <DataNode TextLabel="C18:4" GraphId="afe08" Type="Metabolite">
    <Comment>CCC=CCC=CCC=CCC=CCCCCC(=O)O C18:4(omega 3)(delta6)</Comment>
    <Comment>Stearidonic acid</Comment>
    <Graphics CenterX="456.0329131652659" CenterY="851.2499999999987" Width="90.0" Height="25.0" ZOrder="32864" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030357" />
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  <DataNode TextLabel="C20:4" GraphId="d136b" Type="Metabolite">
    <Graphics CenterX="582.0833333333329" CenterY="851.2499999999987" Width="90.0" Height="25.0" ZOrder="32865" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030818" />
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  <DataNode TextLabel="C20:5" GraphId="a44f4" Type="Metabolite">
    <Comment>AKA eicosapentaenoic acid</Comment>
    <Comment></Comment>
    <Graphics CenterX="729.9682061579645" CenterY="851.2499999999987" Width="90.0" Height="25.0" ZOrder="32866" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030759" />
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  <DataNode TextLabel="C22:5" GraphId="d5985" Type="Metabolite">
    <Comment>Clupanodonic acid; DPA
</Comment>
    <Graphics CenterX="855.7089468987053" CenterY="851.2499999999987" Width="90.0" Height="25.0" ZOrder="32867" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA04000044" />
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  <DataNode TextLabel="C24:5" GraphId="e1d79" Type="Metabolite">
    <Comment>CCC=CCC=CCC=CCC=CCC=CCCCCCCCC(=O)O C24:5(omega 3)(delta6)(delta5)</Comment>
    <Graphics CenterX="982.6070950468529" CenterY="851.2499999999986" Width="90.0" Height="25.0" ZOrder="32868" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030821" />
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  <DataNode TextLabel="C24:6" GraphId="d296c" Type="Metabolite">
    <Comment>Nisinic acid; THA</Comment>
    <Graphics CenterX="1110.6626506024086" CenterY="851.2499999999987" Width="90.0" Height="25.0" ZOrder="32869" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030822" />
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  <DataNode TextLabel="C22:6" GraphId="a5d5c" Type="Metabolite">
    <Comment>AKA docosahexaenoic acid</Comment>
    <Comment></Comment>
    <Graphics CenterX="1240.6163543061118" CenterY="851.2499999999987" Width="90.0" Height="25.0" ZOrder="32870" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030185" />
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  <DataNode TextLabel="C20:3" GraphId="df049" Type="Metabolite">
    <Comment>Dihomo-alpha-linolenic acid</Comment>
    <Graphics CenterX="457.0833333333331" CenterY="902.0929749318418" Width="90.0" Height="25.0" ZOrder="32877" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030378" />
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  <DataNode TextLabel="C34:6" GraphId="ea095" Type="Metabolite">
    <Comment></Comment>
    <Graphics CenterX="1239.2098845452117" CenterY="902.0929749318418" Width="90.0" Height="25.0" ZOrder="32880" FontSize="12" Valign="Middle" Color="0000ff" />
    <Xref Database="LIPID MAPS" ID="LMFA01030842" />
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  <DataNode TextLabel="Elovl5" GraphId="d07f6" Type="GeneProduct">
    <Graphics CenterX="383.9540450176558" CenterY="620.3557002519595" Width="57.0" Height="20.5" ZOrder="32882" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
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  <DataNode TextLabel="Fads2" GraphId="f8667" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
    <Graphics CenterX="382.95404501765574" CenterY="688.7472979243025" Width="50.73511543134913" Height="20.934487903210993" ZOrder="32883" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
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  <DataNode TextLabel="delta-5 ? &#xA;" GraphId="d362f" Type="Protein">
    <Graphics CenterX="382.95404501765586" CenterY="745.4672439516055" Width="50.73511543134913" Height="20.934487903210993" ZOrder="32884" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000010663" />
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  <DataNode TextLabel="Elovl5" GraphId="b2eeb" Type="GeneProduct">
    <Graphics CenterX="520.8389178422879" CenterY="680.8582045970861" Width="57.0" Height="20.5" ZOrder="32887" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
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  <DataNode TextLabel="Fads1" GraphId="c5a63" Type="Protein">
    <Graphics CenterX="664.4436533962028" CenterY="780.9930159184617" Width="50.73511543134914" Height="18.498758672549776" ZOrder="32889" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000010663" />
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  <DataNode TextLabel="Elovl5" GraphId="d54d9" Type="GeneProduct" GroupRef="c5bb8">
    <Graphics CenterX="789.8349017780313" CenterY="792.0710209183791" Width="57.0" Height="20.5" ZOrder="32890" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
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  <DataNode TextLabel="Elovl2" GraphId="a0627" Type="GeneProduct" GroupRef="c5bb8">
    <Graphics CenterX="789.8349017780313" CenterY="773.3293877189145" Width="57.0" Height="20.5" ZOrder="32891" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021364" />
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  <DataNode TextLabel="Elovl2" GraphId="e1678" Type="GeneProduct">
    <Graphics CenterX="917.6394533175228" CenterY="780.9930159184617" Width="57.0" Height="20.5" ZOrder="32893" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021364" />
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  <DataNode TextLabel="Fads2" GraphId="e85c1" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
    <Graphics CenterX="1048.2820235986464" CenterY="780.9930159184614" Width="50.735115431349136" Height="20.393293698731767" ZOrder="32895" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
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  <DataNode TextLabel="Elovl4" GraphId="c09d7" Type="GeneProduct" GroupRef="e2518">
    <Graphics CenterX="1153.2485563965056" CenterY="603.2117912827491" Width="57.0" Height="20.5" ZOrder="32896" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032262" />
  </DataNode>
  <DataNode TextLabel="Elovl2" GraphId="db653" Type="GeneProduct" GroupRef="e2518">
    <Graphics CenterX="1153.2485563965056" CenterY="582.7117912827492" Width="57.0" Height="20.5" ZOrder="32897" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021364" />
  </DataNode>
  <DataNode TextLabel="Perox. &#xA;beta-ox" GraphId="eb6a4" Type="Protein">
    <Graphics CenterX="1172.9082998661313" CenterY="780.9930159184617" Width="67.75769745649268" Height="31.24163319946456" ZOrder="32898" FontSize="12" Valign="Middle" />
    <Xref Database="" ID="" />
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  <DataNode TextLabel="Elovl4" GraphId="a8d2c" Type="GeneProduct" GroupRef="c1259">
    <Graphics CenterX="1142.3174351430896" CenterY="968.233313637879" Width="57.0" Height="20.5" ZOrder="32899" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032262" />
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  <DataNode TextLabel="Elovl2" GraphId="c6eca" Type="GeneProduct" GroupRef="c1259">
    <Graphics CenterX="1142.3174351430896" CenterY="947.7333136378791" Width="57.0" Height="20.5" ZOrder="32900" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000021364" />
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  <DataNode TextLabel="Fads2" GraphId="c3355" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
    <Graphics CenterX="548.4634795240835" CenterY="948.8970830960109" Width="50.735115431349136" Height="20.20583380797825" ZOrder="32906" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
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  <DataNode TextLabel="Elovl5" GraphId="ed928" Type="GeneProduct">
    <Graphics CenterX="347.35832881952996" CenterY="955.4305574435407" Width="57.0" Height="20.5" ZOrder="32907" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
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  <DataNode TextLabel="Elovl5" GraphId="fc1bc" Type="GeneProduct">
    <Graphics CenterX="518.0008991006546" CenterY="822.4261088672278" Width="57.0" Height="20.5" ZOrder="32908" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000032349" />
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  <DataNode TextLabel="Fads2" GraphId="e3e4d" Type="Protein">
    <Comment>Annotated for gene, since:"Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well.[5][6] Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions."(source: Wikipedia)</Comment>
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    <Xref Database="Ensembl" ID="ENSMUSG00000024665" />
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  <DataNode TextLabel="Elovl6" GraphId="c5ffa" Type="Protein" GroupRef="cad25">
    <BiopaxRef>b9f</BiopaxRef>
    <Graphics CenterX="550.0345211581292" CenterY="58.68681697440327" Width="57.0" Height="20.5" ZOrder="32924" FontSize="12" Valign="Middle" />
    <Xref Database="Ensembl" ID="ENSMUSG00000041220" />
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  <DataNode TextLabel="Elovl5" GraphId="e5470" Type="Protein" GroupRef="cad25">
    <BiopaxRef>b9f</BiopaxRef>
    <Graphics CenterX="550.0345211581292" CenterY="79.18681697440331" Width="57.0" Height="20.5" ZOrder="32925" FontSize="12" Valign="Middle" />
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  <Interaction GraphId="id18ab37f9">
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  <Interaction GraphId="id19859bed">
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