<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Estrogen metabolism" Data-Source="WikiPathways" Version="WP1264_r141993" Author="[MaintBot, Khanspers, Mkutmon, Susan, Egonw]" Last-Modified="20251129125231" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Estrogens are metabolized via hydroxylation by cytochrome P450 enzymes such as CYP1A1 and CYP3A4 and via conjugation by estrogen sulfotransferases (sulfation) and UDP-glucuronyltransferases (glucuronidation). In addition, estradiol is dehydrogenated by 17β-Hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions occur primarily in the liver, but also in other tissues.

Description source: [Wikipedia](https://en.wikipedia.org/wiki/Estrogen#Metabolism).</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP697&amp;amp;oldid=30275 WP697(r30275)] with a 71% conversion rate.</Comment>
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