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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Estrogen signaling" Data-Source="WikiPathways" Version="WP1244_r141440" Author="[MaintBot, Khanspers, Christine Chichester, Finterly, Egonw, DeSl]" Last-Modified="20251114122831" Organism="Mus musculus">
  <Comment Source="WikiPathways-description">Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP712&amp;amp;amp;amp;oldid=29739 WP712(r29739)] with a 98% conversion rate.</Comment>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.</bp:TITLE>
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      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Battaglia F</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Merello E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Puppo M</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Piva R</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Varesio L</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bosco MC</bp:AUTHORS>
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    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5">
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ninomiya-Tsuji J</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song YJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jen KY</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Soni V</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kieff E</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cahir-McFarland E</bp:AUTHORS>
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